Search Result

Results for "

model compounds.

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Isotope-Labeled Compounds (1) 5-HT Receptor (1) Adenosine Receptor (1) Adrenergic Receptor (2) Akt (1) Aldose Reductase (1) Aminopeptidase (2) AMPK (2) Amyloid-β (4) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (5) Angiotensin Receptor (5) Antibiotic (2) Apelin Receptor (APJ) (1) Apoptosis (48) ATM/ATR (2) ATP Citrate Lyase (1) Autophagy (3) Bacterial (25) Bcl-2 Family (4) Beta-secretase (1) Biochemical Assay Reagents (8) Btk (1) c-Fms (1) c-Met/HGFR (2) c-Myc (2) Calcium Channel (1) Cannabinoid Receptor (2) Carbonic Anhydrase (3) Caspase (6) CCR (1) CD38 (1) CDK (7) Cholinesterase (ChE) (14) COX (5) CXCR (2) Cytochrome P450 (4) Dengue virus (1) Dihydrofolate reductase (DHFR) (2) DNA/RNA Synthesis (2) Dopamine Receptor (1) Dopamine Transporter (1) Drug-Linker Conjugates for ADC (2) Dynamin (1) DYRK (1) E1/E2/E3 Enzyme (1) EBI2/GPR183 (1) EGFR (6) ELOVL (1) Endogenous Metabolite (3) Enteropeptidase (1) Epigenetic Reader Domain (1) ERK (4) Estrogen Receptor/ERR (7) FAAH (1) FABP (1) FAK (2) Ferroptosis (5) FGFR (5) FLT3 (1) FOXO (1) Fungal (4) FXR (1) G-quadruplex (2) GABA Receptor (3) Galectin (1) Glucocorticoid Receptor (3) Glucosidase (2) GLUT (1) GPR139 (1) GSK-3 (1) HBV (2) HDAC (10) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (4) Histone Methyltransferase (2) HSP (1) Huntingtin (1) ICMT (1) iGluR (4) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (3) Influenza Virus (1) Insulin Receptor (1) Integrin (2) Interleukin Related (4) JAK (2) JNK (2) Keap1-Nrf2 (5) Lipoxygenase (1) LPL Receptor (1) mAChR (1) MAGL (2) MAP3K (1) Mas-related G-protein-coupled Receptor (MRGPR) (1) MDM-2/p53 (3) MEK (1) Melanocortin Receptor (1) mGluR (1) Microtubule/Tubulin (6) Mitochondrial Metabolism (3) Mixed Lineage Kinase (1) Monoamine Oxidase (7) Mps1 (1) mTOR (1) Na+/Ca2+ Exchanger (1) nAChR (1) NAMPT (1) Necroptosis (1) Neurokinin Receptor (1) Neurotensin Receptor (3) NF-κB (13) NO Synthase (4) NOD-like Receptor (NLR) (4) Nuclear Factor of activated T Cells (NFAT) (1) Nuclear Hormone Receptor 4A/NR4A (2) OGA (1) Opioid Receptor (4) Orphan Receptor (1) Oxytocin Receptor (1) P-glycoprotein (1) P2X Receptor (1) P2Y Receptor (2) p38 MAPK (4) Parasite (6) PARP (5) PCSK9 (2) PD-1/PD-L1 (8) PDHK (1) PGE synthase (1) Phosphatase (3) Phosphodiesterase (PDE) (9) Phospholipase (2) PI3K (7) PI4K (2) Piezo Channel (1) PIKfyve (1) Polo-like Kinase (PLK) (1) Porcupine (1) Potassium Channel (3) PPAR (2) PROTACs (11) Protein Arginine Deiminase (1) Proton Pump (1) PSMA (1) Pyroptosis (2) Raf (2) RANKL/RANK (2) Ras (4) Reactive Oxygen Species (11) Renin (1) Reverse Transcriptase (1) RIP kinase (3) ROR (3) ROS Kinase (3) RSV (2) Salt-inducible Kinase (SIK) (2) SARS-CoV (3) SHP2 (1) Sigma Receptor (3) Sirtuin (1) Sodium Channel (1) Somatostatin Receptor (3) STAT (5) STING (1) TAM Receptor (3) Tau Protein (3) Telomerase (1) Thrombin (1) Thymidylate Synthase (1) TNF Receptor (5) Toll-like Receptor (TLR) (5) Topoisomerase (3) Trk Receptor (1) TRP Channel (2) URAT1 (3) VEGFR (1) Virus Protease (2) Wnt (1) Xanthine Oxidase (2) β-catenin (2) γ-secretase (2)
By Research Areas:	Cancer (162) Cardiovascular Disease (19) Endocrinology (8) Infection (41) Inflammation/Immunology (93) Metabolic Disease (22) Neurological Disease (84)
Click Chemistry:	Azide (1) Alkynes (5)

441

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Isotope-Labeled Compounds ATTECs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115768A

Compound 48/80 (trimer) Poly-p-methoxyphenethylmethylamine (trimer)	Others	Others
Compound 48/80 (trimer) is a trimer of Compound 48/80 (HY-115768). Compound 48/80 is widely used in animal and tissue models as a "selective" mast cell activator .

HY-W012515

1,3-Dihydroxyacetone dimer	Biochemical Assay Reagents	Others
1,3-Dihydroxyacetone dimer can be used as an aldose, serving as a model compound for studying the structure and function of carbohydrates. 1,3-Dihydroxyacetone dimer is a kind of biological materials or organic compounds that are widely used in life science research .

HY-129819

(Rac)-DNDI-8219	Bacterial	Infection
(Rac)-DNDI-8219 is an antituberculosis compound with potent anti-leishmanial activity. (Rac)-DNDI-8219 demonstrated superior efficacy in the Leishmania donovani mouse model. (Rac)-DNDI-8219 showed promising activity in the Leishmania infantum hamster model. (Rac)-DNDI-8219 candidate compound R-6 provided excellent oral efficacy in the same hamster model .

HY-139668

VGD071	Neurotensin Receptor	Cancer
VGD071, a sortilin-targeting compound, is a promising candidate for future studies using mouse breast cancer models.

HY-W114954

Guaiacylglycerol-beta-guaiacyl ether	Bacterial	Inflammation/Immunology
Guaiacylglycerol-beta-guaiacyl ether is a model compound of lignin monomers that can be degraded by Bacillus amyloliquefaciens CotA .

HY-119088

Estrogen receptor modulator 12	Others	Others
Estrogen receptor modulator 12 (compound 1a-(R)) is a selective estrogen receptor modulator with estrogen agonist and antagonist activities in in vivo models. Estrogen receptor modulator 12 exhibits antagonist effects on the uterus and estrogen agonist activities on bone, plasma lipids, hot flashes, and vagina in in vivo models, and is a potential compound for suppressing postmenopausal symptoms.

HY-153165

RXR antagonist 5	Others	Others
RXR antagonist 5 (compound 22) is a selective retinoic acid X receptor (RXR) antagonist with binding potential to RXR evaluated by modeling.

HY-109869

Photoregulin1	Others	Others
Photoregulin1 is a compound with the potential to inhibit retinitis pigmentosa that modulates gene expression in retinal cells and slows the degeneration of photoreceptors in a mouse model.

HY-114516

Fructosylvaline	Others	Metabolic Disease
Fructosylvaline (Fructose Valine) is a model fructosyl-amine (Amadori compound) for glycated hemoglobin. Fructosylvaline can be used as a nitrogen source to cultivate microbial strains .

HY-19905

GW-597901	Others	Others
GW-597901 is a compound with bronchodilator activity that has a stronger bronchodilator effect than salbutamol in a human lung reperfusion model, but with a slightly slower onset of action.

HY-122323

L-Leucyl-L-arginine Leucylarginine	Others	Others
L-Leucyl-L-arginine (Leucylarginine) is a compound that inhibits the analgesic effect of systemically administered L-arginine in a carrageenan-induced hyperalgesia model in mice when administered intracerebroventricularly.

HY-123106

MCL-0129	Others	Others
MCL-0129 is a compound with anxiolytic and antidepressant activity and is a selective MC4 receptor antagonist that exhibits anxiolytic and antidepressant-like behaviors in multiple rodent models.

HY-155042

Antihypertensive agent 3	Angiotensin Receptor	Cardiovascular Disease
Antihypertensive agent 3 (compound 4a) is an antagonis of angiotensin II receptor 1. Antihypertensive agent 3 exhibits antihypertensive activity in a spontaneously hypertensive rats (SHRs) model .

HY-160659

Androgen receptor antagonist 10	Androgen Receptor	Endocrinology
Androgen receptor antagonist 10 (compound 6h) is a androgen receptor antagonist. Androgen receptor antagonist 10 reduces the wax esters in the golden syrian hamster model .

HY-145870

Anti-inflammatory agent 13	Others	Inflammation/Immunology
Anti-inflammatory agent 13 (Compound 3) is a pentacyclic triterpene compound. Anti-inflammatory agent 13 exhibits a considerable inhibitory effect on inflammation models. Anti-inflammatory agent 13 has the potential for the research of either DAMPs or PAMPs triggered inflammation .

HY-17035

Doramectin 4 Publications Verification	Parasite Antibiotic Bacterial	Infection
Doramectin is a derivative of Ivermectin (HY-15310). Doramectin is a potent antiparasitic antibiotic. Doramectin is an active compound against S.mansoni in an NMRI mouse infection model .

HY-155146

Anticancer agent 146	Necroptosis	Cancer
Anticancer agent 146 (compound 1.19) is a necroptosis inducer. Anticancer agent 146 has anti-tumor efficacy in the mouse MDA-MB-231 xenograft model .

HY-139364

mPGES1-IN-4	Others	Others
mPGES1-IN-4 (compound 32) is a polysubstituted pyrimidine compound and a submicromolar PGE2 production inhibitor. It exerts its anti-inflammatory effect mainly by inhibiting mPGES-1 and has a significant inhibitory effect on the acute inflammation model in vivo.

HY-139365

mPGES1-IN-5	Others	Others
mPGES1-IN-5 (compound 18) is a polysubstituted pyrimidine compound and a submicromolar PGE2 production inhibitor. It exerts its anti-inflammatory effect mainly by inhibiting mPGES-1 and has a significant inhibitory effect on the acute inflammation model in vivo.

HY-156800

PDDC	Others	Others
PDDC is a compound used to inhibit Alzheimer's disease. It is a nSMase2 inhibitor that can inhibit tau-induced nSMase2 activity and ceramide elevation, and slow the spread of tau in mouse models.

HY-169092

PF-07957472	SARS-CoV Virus Protease	Infection
PF-07957472 (Compound 4) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor. PF-07957472 shows cytopathic effect in SARS-CoV-2 infected NHBE cells (EC₅₀ = 13.9 nM). PF-07957472 shows antiviral effect in a mouse-adapted model of COVID-19 infection model .

HY-167855

MRS4833	P2Y Receptor	Inflammation/Immunology
MRS4833 (compound 15) is an orally active, potent, competitive P2Y₁₄R antagonist with an of IC₅₀ of 5.92 nM for hP2Y₁₄R and an IC₅₀ of 4.8 nM for mP2Y₁₄R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model .

HY-119530

Thiamiprine BW 57-323	Others	Others
Thiamiprine (BW 57-323) is a compound related to azathioprine. Its nucleoside forms are similar to the parent compound in terms of cytotoxicity in vitro (except for the arabinoside). In the rat adjuvant arthritis model in vivo, its riboside and 2'-deoxyriboside are less active than the parent compound. The arabinoside is inactive and nontoxic. It has similar potency to the other parent compounds tested, but has a different safety profile.

HY-106856

Dimiracetam NT-11624	Others	Cancer
Dimiracetam is an orally active compound, with anti-neuropathic activity. Dimiracetam inhibits hypersensitivity and neurological alterations, and inhibits Sorafenib (HY-10201)-induced neuropathy in cold stimulation rat models .

HY-162042

AMPK activator 14	AMPK	Metabolic Disease
AMPK activator 14 (compound 32) is an orally active AMPK activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes .

HY-162694

Ferroptosis-IN-10	Ferroptosis	Neurological Disease
Ferroptosis-IN-10 (compound D1) is an inhibitor of ferroptosis with an IC₅₀ value of 22 nM. Ferroptosis-IN-10 has neuroprotection activity in an oxygen-glucose deprivation/reoxygenation (OGD/R) model .

HY-15208A

Clamikalant HMR 1098 free base	Others	Others
Clamikalant (HMR 1098 free base) is a compound used to suppress cardiac arrhythmias. It prevents the reduction of the refractory period during ventricular fibrillation in dogs and also shows antiarrhythmic effects in a rabbit heart model.

HY-122517

Mirincamycin hydrochloride U-24729 A	Others	Others
Mirincamycin (hydrochloride) (U-24729 A), a compound used to inhibit malaria, has a protective effect against the early liver stages of Plasmodium but fails to kill dormant liver stages of Plasmodium in a rhesus monkey model.

HY-115768

Compound 48/80 Poly-p-methoxyphenethylmethylamine	Others	Neurological Disease Cancer
Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways .

HY-149480

ERD-3111	PROTACs Estrogen Receptor/ERR	Cancer
ERD-3111 (Compound 44) is an orally active PROTAC ERα degrader (DC₅₀: 0.5 nM). ERD-3111 inhibits tumor growth in the parental MCF-7 xenograft model with wild-type ER and two clinically relevant ESR1 mutated mice model. ERD-3111 can be used in the research of ER+ breast cancer .

HY-168501

Neuroprotective agent 6	Others	Inflammation/Immunology
Neuroprotective Agent 6 (Compound Y12) is a neuroprotective agent with antioxidant activity. Neuroprotective Agent 6 demonstrates superior neuroprotective effects in both cellular models induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and animal models induced by transient middle cerebral artery occlusion (tMCAO). Additionally, Neuroprotective Agent 6 exhibits significant metal chelating activity towards Cu ²⁺ .

HY-164040

Zavolosotine	Somatostatin Receptor	Metabolic Disease
Zavolosotine (Compound 1) is an orally active agonist for somatostatin receptor type 5 (SST5) with EC₅₀ <1 nM. Zavolosotine inhibits insulin and glucagon secretion, increases levels of glucagon in blood in rat model .

HY-161705

Anti-apoptotic agent 1	Apoptosis	Neurological Disease
Anti-apoptotic agent 1 (Compound B4) exhibits neuroprotective activity and good pharmacokinetic properties. Anti-apoptotic agent 1 inhibits apoptosis, prevents stroke recurrence in photothrombotic rat model .

HY-116236

THIIC LY2607540	Others	Others
THIIC (LY2607540) is a compound with anxiolytic and antidepressant potential. It is a positive allosteric modulator of mGlu? receptors, exhibits anxiolytic and antidepressant-like activities in multiple animal models, and can also affect sleep and neurochemical changes.

HY-W979493

TC-2216	Others	Others
TC-2216 is a compound with antidepressant and anxiolytic activity that has shown activity in multiple animal models and may exert its effects by acting on α4β2 neuronal nicotinic receptors.

HY-167717

(Rac)-Eflucimibe (Rac)-F 12511	Others	Metabolic Disease
(Rac)-Eflucimibe ((Rac)-F 12511) is an ACAT inhibitor with endogenous hypercholesterolemia modulating activity. (Rac)-Eflucimibe has shown high potency and efficacy as an anti-hypercholesterol compound in different hypercholesterolemia animal models .

HY-144361

Antitumor agent-44	Apoptosis	Cancer
Antitumor agent-44 (Compound 5n) disrupts the mitochondrial homeostasis, induces cell cycle arrest and apoptosis in human adenocarcinoma cells. Antitumor agent-44 (Compound 5n) possesses good anti-tumor activity in a lung-cancer-cell xenograft mice model .

HY-W158160

AGS1286 sodium	Others	Infection
AGS1286 (sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate) is an organosulfur compound that serves as a model for investigating the impact of sulfur-containing compounds on enzymatic activities and metabolic pathways. Additionally, it has been employed to explore the regulatory effects of these compounds on bacterial growth and gene expression.

HY-146615

Axl-IN-6	TAM Receptor	Cancer
Axl-IN-6 (compound 14) is an orally active and potent AXL inhibitor. Axl-IN-6 is well tolerated and significantly inhibits the tumor growth in MV-4-11 subcutaneous xenograft model .

HY-131545

Parogrelil NT-702 free base; NT-702 free base	Others	Others
Parogrelil (NT-702 free base) is a compound with intermittent claudication inhibitory activity that inhibits PDE3, inhibits platelet aggregation and vasoconstriction, and improves walking distance and plantar surface temperature in a rat experimental model.

HY-138969

(±)10(11)-EDP ethanolamide 10,11-EDP-EA; 10,11-EDP epoxide; 10,11-Epoxy docosapentaenoic ethanolamide	Others	Others
(±)10(11)-EDP ethanolamide (10,11-EDP-EA) (compound C) is an ω-3 endocannabinoid epoxide derivative with antiangiogenic, antitumor and anti-migratory properties in osteosarcoma models.

HY-157456

RIPK1-IN-19	RIP kinase	Inflammation/Immunology
RIPK1-IN-19 (compound 10b) is a selective RIPK1 inhibitor (IC₅₀=15 nM). RIPK1-IN-19 displays potent protective activity in TNFα-induced systemic inflammatory response syndrome (SIRS) model and Imiquimod (IMQ)-induced psoriasis model. RIPK1-IN-19 can be used in research on inflammation and immune system diseases .

HY-145704

Antimalarial agent 8	Parasite	Infection
Antimalarial agent 8 (Compound 7e) is a novel orally active class of antimalarials. Antimalarial agent 8 is potent in vitro against P. falciparum and is orally efficacious (40 mg/kg) in an in vivo mouse model of malaria .

HY-146465

Anticancer agent 60	Microtubule/Tubulin	Cancer
Anticancer agent 60 (compound 3h) has antiproliferative activity against human HepG2 cells (IC₅₀ = 4.13 μM) and presents antitumor efficacy in a human HepG2 xenograft mouse model .

HY-162013

NLRP3-IN-26	NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology
NLRP3-IN-26 (compound 15Z) is a NLRP3 inhibitor with the IC₅₀ of 0.13 μM. NLRP3-IN-26 can be used for DSS-induced colitis model study .

HY-161065

HKI12134085	Bacterial	Infection
HKI12134085 (compound 3) is an orally available antibacterial nitrobenzothiazinone (BTZ) derivative with activity against Mycobacterium tuberculosis. HKI12134085 has in vivo inhibitory potency in a BALB/c mouse model of Mycobacterium tuberculosis infection .

HY-162786

Nurr1 agonist 11	Nuclear Hormone Receptor 4A/NR4A	Neurological Disease
Nurr1 agonist 11 (compound 53) is a selective and potent Nurr1 agonist with an IC₅₀ of 26 µM. Nurr1 agonist 11 has the ability to cross a cellular model of the blood-brain-barrier (BBB) .

HY-19155A

ICI-D 8731 ZD-8731	Angiotensin Receptor	Cardiovascular Disease
ICI-D 8731 (compound 5g) is a angiotensin II receptor antagonist with the IC₅₀ of 0.031 μM. ICI-D 8731 shows a rapid and sustained lowering of blood pressure in a renal hypertensive rat model .

HY-165027

DL-1′-Acetoxychavicol acetate	Others	Others
DL-1′-Acetoxychavicol acetate is a compound with anti-inflammatory and anticancer preventive potential that inhibits the activities of NOX, iNOS, and COX-2 in inflammatory cells and exhibits preventive activity in multiple inflammation-related cancer models.

HY-19602

Cedefingol	Others	Cancer
Cedefingol is an antitumor compound with α-glucosidase inhibitory activity. Cedefingol was identified together with other compounds in fermented dark tea samples. The biotransformation of cedefingol is related to enzymatic hydrolysis, hydrolysis and biosynthesis. Cedefingol exhibited different bioactivities in samples with different fermentation times. The antioxidant properties of cedefingol showed certain activity in the DPPH model .

Cat. No.	Product Name

HY-L097

Animal Disease Model Inducer Library

51 compounds

Animal disease models are used in a variety of settings in basic research, such as studies on mechanisms of disease progression and evaluation new drugs. Animal models can be broadly classified into five categories: 1) experimental, 2) spontaneous, 3) negative, 4) orphan, 5) genetically engineered. Experimental models, which are induced artificially in the laboratory, are most common. Some small molecular compounds are usually used as inducers for animal models, such as Ceruletide for inflammatory model, Azoxymethane for tumor model. These inducers are useful tool in building animal models.

MCE offers a unique collection of 51 animal model inducers, involving inflammatory model, tumor model, nervous disease model, etc. MCE Animal Disease Model library is a powerful tool for the establishment of animal disease models.

HY-L917

RNA Binding Library

5,000 compounds

RNA is crucial for the regulation of numerous cellular processes and functions. With the in-depth study of disease mechanisms, processes such as RNA expression, splicing, translation, and stability regulation have become new targets for disease intervention. RNA has provided new therapeutic modalities for metabolic diseases, genetic disorders, and cancer patients, resulting in several innovative drugs.

MCE R&D team collected small molecules targeting RNA from the PDB, R-BIND, ROBIN, and internal database as the positive dataset, and non-targeting RNA small molecules from ROBIN as the negative dataset. Based on the GeminiMol pre-trained model, we encoded the molecules and calculated over 1700 molecular descriptors using Mordred as inputs for the model. Subsequently, we employed 13 deep learning models to learn from the data. All of which yielded good training results, with AUROCs greater than 0.75. Ultimately, we selected the Finetune model to screen HY-L901P, which exhibited the best classification performance, achieving an AUROC of 0.82 and a prediction accuracy of 0.76. We then applied filtering based on StaR rules (with at least two of the following properties: cLogP ≥ 1.5, Molar Refractivity ≥ 4, Relative Polar Surface Area ≤ 0.3) to obtain a library containing approximately 5,000 small molecule compounds targeting RNA. This library serves as a valuable tool for screening small molecules that interact with RNA.

HY-L100

Tumorigenesis-Related Compound Library

136 compounds

Cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathophysiologic states such as inflammation. The administration of chemical carcinogens is one of the most commonly used methods to induce tumors in several organs in laboratory animals in order to study oncologic diseases of humans. MCE offers a unique collection of 136 chemical carcinogens which have been identified with carcinogenic activity either in humans or in animal models. MCE Tumorigenesis-Related Compound Library is a powerful tool for studying oncologic diseases of humans. Standard opration based on safety data sheet will not cause harm to the body.

HY-L039

Reprogramming Compound Library

2,182 compounds

Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since Yamanaka reprogrammed somatic cells to become induced pluripotent stem cells (iPSCs) using four transcription factors, OCT4, SOX2, KLF4, and c-MYC in 2006. Despite the development of efficient reprogramming methods, most methods are inappropriate for clinical applications because they carry the risk of integrating exogenous genetic factors or use oncogenes. Alternative approaches, such as those based on miRNA, non-viral genes, non-integrative vectors, and small molecules, have been studied as possible solutions to the problems. Among these alternatives, small molecules are attractive options for clinical applications. Reprogramming using small molecules is inexpensive and easy to control in a concentration- and time-dependent manner. It offers a high level of cell permeability, ease of synthesis and standardization, and it is appropriate for mass-producing cells.

MCE Reprogramming Compound Library contains a unique collection of 2,182 compounds that act on reprogramming signaling pathways. These compounds are potential stimulators for reprogramming. This library is a useful tool for researching reprogramming and regenerative medicine.

HY-L0115V

Asinex Macrocycles Library

10,091 compounds

ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel, tremendously diverse, medchem-relevant, macrocyclic frameworks.

Macrocyles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such asaqueous solubility and membrane permeability. Many of these macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay.

HY-L059

Pyroptosis Compound Library

1,368 compounds

Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.

MCE designs a unique collection of 1,368 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

Cat. No.	Product Name	Type

HY-103609

Pyrene

Benzo[def]phenanthrene

Dyes

Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.

HY-103609R

Pyrene (Standard)

Dyes

Pyrene (Standard) is the analytical standard of Pyrene. This product is intended for research and analytical applications. Pyrene is a polycyclic aromatic hydrocarbon (PAH) composed of four fused benzene rings. It has a distinct aromatic odor, produced by incomplete combustion of organic matter. Pyrene exhibits strong fluorescence, emitting in the blue region of the spectrum, making it useful as a probe for studying molecular interactions in solution and on surfaces. Pyrene is also used as a model compound for the study of PAHs in various environments and biological systems because of its ubiquity in these environments. However, long-term exposure to pyrene has been associated with potential health risks, including carcinogenicity and mutagenicity.

Cat. No.	Product Name	Type

HY-W015236

H-Gly-Gly-Gly-OH

Triglycine

Chelators

H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.

HY-W099563

4-Nitrophenyl stearate

Enzyme Substrates

4-Nitrophenyl stearate, which is an ester formed by the condensation of stearic acid and 4-nitrophenol, is commonly used as a substrate for enzymatic assays, where the hydrolysis of ester bonds by esterase and lipase can be measured by absorbance or ratio In addition, 4-Nitrophenyl stearate has been used as a model compound to study the enzymatic activity and selectivity of lipases and esterases from various sources. The long hydrophobic tail of the molecule makes it suitable for use in lipophilic Good solubility in the environment makes it a useful probe for studying lipid metabolism.

HY-W012515

1,3-Dihydroxyacetone dimer	Carbohydrates
1,3-Dihydroxyacetone dimer can be used as an aldose, serving as a model compound for studying the structure and function of carbohydrates. 1,3-Dihydroxyacetone dimer is a kind of biological materials or organic compounds that are widely used in life science research .

HY-167810

1,3-Dipentadecanoin(C15:0)	Drug Delivery
1,3-Dipentadecanoin(C15:0) is a long-chain triglyceride with substrate activity for lipid metabolism studies. 1,3-Dipentadecanoin(C15:0) is used as a model compound for studying the hydrolysis of triglycerides by lipase. 1,3-Dipentadecanoin(C15:0) can help understand the metabolic mechanism of triglycerides in chemical research.

HY-W015236R

H-Gly-Gly-Gly-OH (Standard)

Chelators

H-Gly-Gly-Gly-OH (Standard) is the analytical standard of H-Gly-Gly-Gly-OH. This product is intended for research and analytical applications. H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.

Cat. No.	Product Name	Target	Research Area

HY-P10767

MD01-67	Neurotensin Receptor	Neurological Disease
MD01-67 is a selective macrocyclic compound targeting the neurotensin receptor type 2 (NTS2), with K_i of 2.9 nM. MD01-67 exhibits analgesic and tactile hypersensitivity reducing activity in rats acute/persistent/chronic inflammatory pain models .

HY-P3355

p-fin4	iGluR	Neurological Disease
p-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators .

HY-149941

hNTS1R agonist-1	Neurotensin Receptor	Neurological Disease
hNTS1R agonist-1 (Compound 10) is a BBB permeable hNTS1R full agonist (K_i: 6.9 nM) . hNTS1R agonist-1 increases motor function and memory in a mouse model of Parkinson's disease (PD). hNTS1R agonist-1 is a Neurotensin(8-13) analog and is a neuroprotective agent .

HY-P3354

p3Ysh-3	iGluR	Neurological Disease
p3Ysh-3 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 1.09 μM. p3Ysh-3 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p3Ysh-3 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators .

HY-P6437

Drp1 peptide inhibitor P110	Dynamin	Cardiovascular Disease Neurological Disease
Drp1 peptide inhibitor P110 (Compound P110) is a selective Drp1 peptide inhibitor with neuroprotective properties. Drp1 peptide inhibitor P110 can inhibit the activation of Drp1, prevent MPTP-induced Drp1 mitochondrial translocation, and alleviate MPTP-induced dopaminergic neuron loss, dopaminergic nerve terminal damage, and behavioral deficits, and can be used in the study of Alzheimer's disease. Additionally, Drp1 peptide inhibitor P110 can reduce mitochondrial damage and organ injury in animal models of Huntington's disease, cerebral ischemic injury, and myocardial infarction .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17035

Doramectin 4 Publications Verification	Infection Structural Classification Microorganisms Antibiotics Source classification Anti-parasitic Antibacterial Disease Research Disease Research Fields Other Antibiotics	Parasite Antibiotic Bacterial
Doramectin is a derivative of Ivermectin (HY-15310). Doramectin is a potent antiparasitic antibiotic. Doramectin is an active compound against S.mansoni in an NMRI mouse infection model .

HY-N6073

Soyasapogenol A	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Soyasapogenol A, a triterpene compound, isolated from soybean. Soyasapogenol A directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α, which consequently results in the prevention of liver damage in the Concanavalin A-induced hepatitis model .

HY-17035R

Doramectin (Standard)	Structural Classification Microorganisms Antibiotics Source classification Anti-parasitic Antibacterial Disease Research Other Antibiotics	Parasite Antibiotic Bacterial
Doramectin (Standard) is the analytical standard of Doramectin. This product is intended for research and analytical applications. Doramectin is a derivative of Ivermectin (HY-15310). Doramectin is a potent antiparasitic antibiotic. Doramectin is an active compound against S.mansoni in an NMRI mouse infection model .

HY-113218

Acetyl-L-carnitine 2 Publications Verification O-Acetyl-L-carnitine; ALCAR	Structural Classification Natural Products Animals Source classification	Others
Acetyl-L-carnitine (O-Acetyl-L-carnitine) is a compound involved in human metabolic research. It has relevant applications in predicting metabolite biomarker changes using the Recon 2 metabolic reconstruction model and integrating and analyzing multiple data types, but its specific activity mechanism is not described in detail based on the existing information.

HY-N0213

Peiminine 4 Publications Verification Verticinone; Raddeanine	Alkaloids Piperidine Alkaloids Structural Classification Fritillaria thunbergii Miq. Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis
Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

HY-W083376A

4-Methoxychalcone-1	Structural Classification Chalcones Flavonoids Source classification Plants Moraceae Ficus pandurata Hance	Others
4-Methoxychalcone is a naturally occurring chalcone compound. 4-Methoxychalcone has antioxidant activity, anti-inflammatory activity, antitumor activity and antibacterial activity. 4-Methoxychalcone can be used to study inflammation and tumor models .

HY-126359

1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine SLPC; 18:0-18:2 PC	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine can be chosen as a model used to investigate the volatile compounds from oxidised phosphatidylcholine molecular species. This method is applied to a real food sample, i.e. soy lecithin .

HY-N10447

Kurzipene D	Terpenoids Source classification Casearia kurzii C. B. Clarke Diterpenoids Plants Salicaceae	Apoptosis
Kurzipene D (compound 4) is a potent anticancer agent. Kurzipene D induces the apoptosis and arrested the HepG2 cell cycle at S stage. Kurzipene D shows anti-tumor effects using in vivo zebrafish model. Kurzipene D has the property of inhibiting tumor proliferation and migration .

HY-N6073R

Soyasapogenol A (Standard)	Triterpenes Structural Classification Leguminosae Glycine max (L.) merr Terpenoids Source classification Plants	Apoptosis
Soyasapogenol A (Standard) is the analytical standard of Soyasapogenol A. This product is intended for research and analytical applications. Soyasapogenol A, a triterpene compound, isolated from soybean. Soyasapogenol A directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α, which consequently results in the prevention of liver damage in the Concanavalin A-induced hepatitis model .

HY-N8960

1-Hydroxybisabola-2,10-dien-4-one	Structural Classification Natural Products Terpenoids Sesquiterpenes Source classification Piperaceae Plants Piper retrofractum Vahl	Others
1-Hydroxybisabola-2,10-dien-4-one is a compound with potential anti-Alzheimer's disease activity. The activity of 1-Hydroxybisabola-2,10-dien-4-one was evaluated in the Caenorhabditis elegans Alzheimer's disease pathological model. 1-Hydroxybisabola-2,10-dien-4-one has a wide range of applications in life science related research .

HY-N14035

Garcinia cambogia extract	Structural Classification Natural Products Guttiferae Source classification Garcinia cambogia Desr. Plants	ATP Citrate Lyase
Garcinia cambogia extract contains several active compounds, including hydroxycitric acid (HCA) (an ECC inhibitor), xanthones, benzophenones, hydroxycitric acid (an ATP-citrate lyase inhibitor). Garcinia cambogia extract lowers the body weight gain, visceral fat accumulation, blood and hepatic lipid concentrations, and plasma insulin and leptin levels in a high-fat diet (HFD)-induced obesity mouse model. Garcinia cambogia extract is promising for research of fatty liver, dyslipidemia, hyperinsulinemia and hyperleptinemia rendered by HFD .

HY-N0213R

Peiminine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Fritillaria thunbergii Miq. Liliaceae Source classification Plants	Autophagy Caspase Bcl-2 Family PARP p38 MAPK ERK NF-κB Apoptosis
Peiminine (Standard) is the analytical standard of Peiminine. This product is intended for research and analytical applications. Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models .

HY-N13083

PCSK9-IN-28	Structural Classification Terpenoids Source classification Diterpenoids Euphorbia esula L. Euphorbiaceae Plants	PCSK9
PCSK9-IN-28 (Compound C11) is a PCSK9 inhibitor that can be isolated from Euphorbia esula. By binding to HNF1α, PCSK9-IN-28 inhibits PCSK9 transcription by binding to HNF1α and affecting its nuclear distribution, thereby enhancing LDLR and promoting LDL uptake. PCSK9-IN-28 exhibits significant lipid-lowering activity in the high-fat diet (HFD) mouse model and can be used in the study of hyperlipidemia .

HY-16468

Squalamine MSI-1256	Infection Triterpenes Structural Classification Animals Classification of Application Fields Terpenoids Marine natural products Other marine organisms Disease Research Fields Cancer	Bacterial HBV FAK Dengue virus
Squalamine (MSI-1256) is an aminosterol compound with broad-spectrum antiviral activity. Squalamine makes cells less conducive to certain viral replication by altering the electrostatic interactions in the inner membrane of host cells. Squalamine also has antibacterial and antitumor activities. Squalamine has broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Squalamine inhibits tumor-related angiogenesis and the growth of human breast cancer cells. Squalamine restores the function of enteric nervous system in Parkinson ^,s disease mouse models .

HY-N10439

3β-Acetoxy-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Source classification Euphorbiaceae Plants	Glucosidase
3β-Acetoxy-hop-22(29)-ene (compound 1) is a potent anti-inflammatory agent. 3β-Acetoxy-hop-22(29)-ene shows high inhibitory activity of yeast α-glucosidase, with an IC₅₀ of 5.74 μM. 3β-Acetoxy-hop-22(29)-ene inhibits MPO (myeloperoxidase) activity in a dose-dependent manner in mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA), with an IC₅₀ of 0.23 μmol/ear .

Cat. No.	Product Name	Chemical Structure

HY-157029S

KRASG12D-IN-1
KRASG12D-IN-1 (compound 22) is a KRAS ^G12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition .

HY-157031S

KRASG12D-IN-2
KRASG12D-IN-2 (compound 28) is a KRAS ^G12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition .

HY-113218S

Acetyl-L-carnitine-d9

Acetyl-L-carnitine-d₉ (O-Acetyl-L-carnitine-d₉) is deuterium labeled Acetyl-L-carnitine. Acetyl-L-carnitine (O-Acetyl-L-carnitine) is a compound involved in human metabolic research. It has relevant applications in predicting metabolite biomarker changes using the Recon 2 metabolic reconstruction model and integrating and analyzing multiple data types, but its specific activity mechanism is not described in detail based on the existing information .

HY-169332

Piezo1 agonist 1-d2
Piezo1 agonist 1-d₂ (Compound 12a) is an agonist for Piezo1 with an EC₅₀ of 2.21 μM. Piezo1 agonist 1-d₂ activates the Ca ²⁺-related ERK signaling pathway, and thus promotes the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Piezo1 agonist 1-d₂ ameliorates disuse osteoporosis in the hindlimb-unloading (HU) rat model .

Cat. No.	Product Name		Classification

HY-157029S

KRASG12D-IN-1		Alkynes
KRASG12D-IN-1 (compound 22) is a KRAS ^G12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition .

HY-157031S

KRASG12D-IN-2		Alkynes
KRASG12D-IN-2 (compound 28) is a KRAS ^G12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition .

HY-Y1230

4-Pentynoic acid Propargylacetic acid		Alkynes
4-Pentynoic acid (Propargylacetic acid) is an intermediate to produce biologically active compounds. 4-Pentynoic acid is widely utilized as a building block for the synthesis of eight sequence-defined model oligomers . 4-Pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-156519

ALPK1-IN-3		Alkynes
ALPK1-IN-3 is an inhibitor of ALPK1 extracted from patent WO2022063153A1 compound T007. ALPK1-IN-3 inhibits kidney proinflammatory gene expression and improves the survival rate of the animals in sepsis induced acute kidney injury animal model . ALPK1-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-157411

anti-TNBC agent-5		Alkynes
anti-TNBC agent-5 (compound 10C) is a triple-negative breast cancer (TNBC) inhibitor with good stability and pharmacokinetic properties. anti-TNBC agent-5 exhibits antiproliferative activity against a variety of cancer cells. anti-TNBC agent-5 can also effectively inhibit TNBC lung metastasis activity in the MDA-MB-231 xenograft model. anti-TNBC agent-5 can be used in cancer research .

HY-159519

EGFR/HER2-IN-16		Azide
EGFR/HER2-IN-16 (compound 12K) is an effective dual-target inhibitor of EGFR (IC₅₀=6.15 nM) and HER-2 (IC₅₀=9.78 nM) with anti-tumor activity. EGFR/HER2-IN-16 can inhibit the migration of SK-BR-3 cells, arrest the cell cycle in the G0/G1 phase, and induce apoptosis. EGFR/HER2-IN-16 exhibits good anti-proliferative activity against tumor cell models and has little damage to healthy cells. EGFR/HER2-IN-16 can be used in breast cancer research .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks