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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-115768A
    Compound 48/80 (trimer)

    Poly-p-methoxyphenethylmethylamine (trimer)

    		 Phospholipase Others
    Compound 48/80 (trimer) is a trimer of Compound 48/80 (HY-115768). Compound 48/80 is widely used in animal and tissue models as a "selective" mast cell activator .
    Compound 48/80 (trimer)
  • HY-W114954
    Guaiacylglycerol-beta-guaiacyl ether

    		Bacterial Inflammation/Immunology
    Guaiacylglycerol-beta-guaiacyl ether is a model compound of lignin monomers that can be degraded by Bacillus amyloliquefaciens CotA .
    Guaiacylglycerol-beta-guaiacyl ether
  • HY-B0535
    Ethambutol
    1 Publications Verification

    		 Bacterial Antibiotic Infection
    Ethambutol is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. Ethambutol can be used to establish animal models of hyperuricemia and optic neuropathy.
    Ethambutol
  • HY-W012515
    1,3-Dihydroxyacetone dimer

    		Biochemical Assay Reagents Others
    1,3-Dihydroxyacetone dimer can be used as an aldose, serving as a model compound for studying the structure and function of carbohydrates. 1,3-Dihydroxyacetone dimer is a kind of biological materials or organic compounds that are widely used in life science research .
    1,3-Dihydroxyacetone dimer
  • HY-129819
    (Rac)-DNDI-8219

    		Bacterial Infection
    (Rac)-DNDI-8219 is an antituberculosis compound with potent anti-leishmanial activity. (Rac)-DNDI-8219 demonstrated superior efficacy in the Leishmania donovani mouse model. (Rac)-DNDI-8219 showed promising activity in the Leishmania infantum hamster model. (Rac)-DNDI-8219 candidate compound R-6 provided excellent oral efficacy in the same hamster model .
    (Rac)-DNDI-8219
  • HY-139668
    VGD071

    		Neurotensin Receptor Cancer
    VGD071, a sortilin-targeting compound, is a promising candidate for future studies using mouse breast cancer models.
    VGD071
  • HY-119088
    Estrogen receptor modulator 12

    		Estrogen Receptor/ERR Others
    Estrogen receptor modulator 12 (compound 1a-(R)) is a selective estrogen receptor modulator with estrogen agonist and antagonist activities in in vivo models. Estrogen receptor modulator 12 exhibits antagonist effects on the uterus and estrogen agonist activities on bone, plasma lipids, hot flashes, and vagina in in vivo models, and is a potential compound for suppressing postmenopausal symptoms.
    Estrogen receptor modulator 12
  • HY-153165
    RXR antagonist 5

    		RAR/RXR Others
    RXR antagonist 5 (compound 22) is a selective retinoic acid X receptor (RXR) antagonist with binding potential to RXR evaluated by modeling.
    RXR antagonist 5
  • HY-109869
    Photoregulin1

    		Orphan Receptor Others
    Photoregulin1 is a compound with the potential to inhibit retinitis pigmentosa that modulates gene expression in retinal cells and slows the degeneration of photoreceptors in a mouse model.
    Photoregulin1
  • HY-114516
    Fructosylvaline

    		Others Metabolic Disease
    Fructosylvaline (Fructose Valine) is a model fructosyl-amine (Amadori compound) for glycated hemoglobin. Fructosylvaline can be used as a nitrogen source to cultivate microbial strains .
    Fructosylvaline
  • HY-B0535A
    Ethambutol dihydrochloride
    1 Publications Verification

    Emb dihydrochloride

    		 Bacterial Antibiotic Infection
    Ethambutol dihydrochloride is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. Ethambutol dihydrochloride can be used to establish animal models of hyperuricemia and optic neuropathy.
    Ethambutol dihydrochloride
  • HY-173030
    Opioid receptor agonist 1

    		Opioid Receptor Neurological Disease
    Opioid receptor agonist 1 (Compound 2638-28) is the orally active agonist for opioid receptor that exhibits good affinity to MOR, DOR and KOR with Ki of 5, 24 and 212 nM, respectively. Opioid receptor agonist 1 exhibits analgesic activity in mouse warm water tail flick models and acetic acid writhing models .
    Opioid receptor agonist 1
  • HY-122323
    L-Leucyl-L-arginine

    Leucylarginine

    		 Amino Acid Derivatives Others
    L-Leucyl-L-arginine (Leucylarginine) is a compound that inhibits the analgesic effect of systemically administered L-arginine in a carrageenan-induced hyperalgesia model in mice when administered intracerebroventricularly.
    L-Leucyl-L-arginine
  • HY-123106
    MCL-0129

    		Melanocortin Receptor Others
    MCL-0129 is a compound with anxiolytic and antidepressant activity and is a selective MC4 receptor antagonist that exhibits anxiolytic and antidepressant-like behaviors in multiple rodent models.
    MCL-0129
  • HY-19905
    GW-597901

    		Adrenergic Receptor Others
    GW-597901 is a compound with bronchodilator activity that has a stronger bronchodilator effect than salbutamol in a human lung reperfusion model, but with a slightly slower onset of action.
    GW-597901
  • HY-168719
    PPARγ agonist 16

    		PPAR Inflammation/Immunology
    PPARγ agonist 16 (Compound 4G) is the agonist for PPARγ, that competitively binds to LBD domain of PPARγ with IC50 of 1790 nM. PPARγ agonist 16 inhibits the ear swelling in mouse model, and exhibits anti-hyperglycemic in Streptozotocin (HY-13753)-induced mouse diabetes mellitus model .
    PPARγ agonist 16
  • HY-160659
    Androgen receptor antagonist 10

    		Androgen Receptor Endocrinology
    Androgen receptor antagonist 10 (compound 6h) is a androgen receptor antagonist. Androgen receptor antagonist 10 reduces the wax esters in the golden syrian hamster model .
    Androgen receptor antagonist 10
  • HY-155042
    Antihypertensive agent 3

    		Angiotensin Receptor Cardiovascular Disease
    Antihypertensive agent 3 (compound 4a) is an antagonis of angiotensin II receptor 1. Antihypertensive agent 3 exhibits antihypertensive activity in a spontaneously hypertensive rats (SHRs) model .
    Antihypertensive agent 3
  • HY-145870
    Anti-inflammatory agent 13

    		NO Synthase Inflammation/Immunology
    Anti-inflammatory agent 13 (Compound 3) is a pentacyclic triterpene compound. Anti-inflammatory agent 13 exhibits a considerable inhibitory effect on inflammation models. Anti-inflammatory agent 13 has the potential for the research of either DAMPs or PAMPs triggered inflammation .
    Anti-inflammatory agent 13
  • HY-17035
    Doramectin
    5 Publications Verification

    		 Parasite Antibiotic Bacterial Infection
    Doramectin is a derivative of Ivermectin (HY-15310). Doramectin is a potent antiparasitic antibiotic. Doramectin is an active compound against S.mansoni in an NMRI mouse infection model .
    Doramectin
  • HY-155146
    Anticancer agent 146

    		Necroptosis Cancer
    Anticancer agent 146 (compound 1.19) is a necroptosis inducer. Anticancer agent 146 has anti-tumor efficacy in the mouse MDA-MB-231 xenograft model .
    Anticancer agent 146
  • HY-139364
    mPGES1-IN-4

    		PGE synthase Others
    mPGES1-IN-4 (compound 32) is a polysubstituted pyrimidine compound and a submicromolar PGE2 production inhibitor. It exerts its anti-inflammatory effect mainly by inhibiting mPGES-1 and has a significant inhibitory effect on the acute inflammation model in vivo.
    mPGES1-IN-4
  • HY-139365
    mPGES1-IN-5

    		PGE synthase Others
    mPGES1-IN-5 (compound 18) is a polysubstituted pyrimidine compound and a submicromolar PGE2 production inhibitor. It exerts its anti-inflammatory effect mainly by inhibiting mPGES-1 and has a significant inhibitory effect on the acute inflammation model in vivo.
    mPGES1-IN-5
  • HY-156800
    PDDC

    		Phospholipase Others
    PDDC is a compound used to inhibit Alzheimer's disease. It is a nSMase2 inhibitor that can inhibit tau-induced nSMase2 activity and ceramide elevation, and slow the spread of tau in mouse models.
    PDDC
  • HY-167855
    MRS4833

    		P2Y Receptor Inflammation/Immunology
    MRS4833 (compound 15) is an orally active, potent, competitive P2Y14R antagonist with an of IC50 of 5.92 nM for hP2Y14R and an IC50 of 4.8 nM for mP2Y14R. MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model .
    MRS4833
  • HY-169092
    PF-07957472

    		SARS-CoV Virus Protease Infection
    PF-07957472 (Compound 4) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor. PF-07957472 shows cytopathic effect in SARS-CoV-2 infected NHBE cells (EC50 = 13.9 nM). PF-07957472 shows antiviral effect in a mouse-adapted model of COVID-19 infection model .
    PF-07957472
  • HY-119530
    Thiamiprine

    BW 57-323

    		 Nucleoside Antimetabolite/Analog Others
    Thiamiprine (BW 57-323) is a compound related to azathioprine. Its nucleoside forms are similar to the parent compound in terms of cytotoxicity in vitro (except for the arabinoside). In the rat adjuvant arthritis model in vivo, its riboside and 2'-deoxyriboside are less active than the parent compound. The arabinoside is inactive and nontoxic. It has similar potency to the other parent compounds tested, but has a different safety profile.
    Thiamiprine
  • HY-122517
    Mirincamycin hydrochloride

    U-24729 A

    		 Parasite Others
    Mirincamycin (hydrochloride) (U-24729 A), a compound used to inhibit malaria, has a protective effect against the early liver stages of Plasmodium but fails to kill dormant liver stages of Plasmodium in a rhesus monkey model.
    Mirincamycin hydrochloride
  • HY-124406
    A-794282

    		mGluR Neurological Disease
    A-794282 is a compound with analgesic activity and is a selective mGlu1 receptor antagonist that significantly reduces pain behaviors in a postoperative pain model, but motor side effects may occur at higher doses.
    A-794282
  • HY-162694
    Ferroptosis-IN-10

    		Ferroptosis Neurological Disease
    Ferroptosis-IN-10 (compound D1) is an inhibitor of ferroptosis with an IC50 value of 22 nM. Ferroptosis-IN-10 has neuroprotection activity in an oxygen-glucose deprivation/reoxygenation (OGD/R) model .
    Ferroptosis-IN-10
  • HY-106856
    Dimiracetam

    NT-11624

    		 iGluR Cancer
    Dimiracetam is an orally active compound, with anti-neuropathic activity. Dimiracetam inhibits hypersensitivity and neurological alterations, and inhibits Sorafenib (HY-10201)-induced neuropathy in cold stimulation rat models .
    Dimiracetam
  • HY-162042
    AMPK activator 14

    		AMPK Metabolic Disease
    AMPK activator 14 (compound 32) is an orally active AMPK activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes .
    AMPK activator 14
  • HY-15208A
    Clamikalant

    HMR 1098 free base

    		 Others Others
    Clamikalant (HMR 1098 free base) is a compound used to suppress cardiac arrhythmias. It prevents the reduction of the refractory period during ventricular fibrillation in dogs and also shows antiarrhythmic effects in a rabbit heart model.
    Clamikalant
  • HY-115768
    Compound 48/80

    Poly-p-methoxyphenethylmethylamine

    		 Phospholipase Neurological Disease Cancer
    Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways .
    Compound 48/80
  • HY-168501
    Neuroprotective agent 6

    		Others Inflammation/Immunology
    Neuroprotective Agent 6 (Compound Y12) is a neuroprotective agent with antioxidant activity. Neuroprotective Agent 6 demonstrates superior neuroprotective effects in both cellular models induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and animal models induced by transient middle cerebral artery occlusion (tMCAO). Additionally, Neuroprotective Agent 6 exhibits significant metal chelating activity towards Cu 2+ .
    Neuroprotective agent 6
  • HY-149480
    ERD-3111

    		PROTACs Estrogen Receptor/ERR Cancer
    ERD-3111 (Compound 44) is an orally active PROTAC ERα degrader (DC50: 0.5 nM). ERD-3111 inhibits tumor growth in the parental MCF-7 xenograft model with wild-type ER and two clinically relevant ESR1 mutated mice model. ERD-3111 can be used in the research of ER+ breast cancer .
    ERD-3111
  • HY-167717
    (Rac)-Eflucimibe

    (Rac)-F 12511

    		 Endogenous Metabolite Metabolic Disease
    (Rac)-Eflucimibe ((Rac)-F 12511) is an ACAT inhibitor with endogenous hypercholesterolemia modulating activity. (Rac)-Eflucimibe has shown high potency and efficacy as an anti-hypercholesterol compound in different hypercholesterolemia animal models .
    (Rac)-Eflucimibe
  • HY-116236
    THIIC

    LY2607540

    		 mGluR Others
    THIIC (LY2607540) is a compound with anxiolytic and antidepressant potential. It is a positive allosteric modulator of mGlu? receptors, exhibits anxiolytic and antidepressant-like activities in multiple animal models, and can also affect sleep and neurochemical changes.
    THIIC
  • HY-164040
    Zavolosotine

    		Somatostatin Receptor Metabolic Disease
    Zavolosotine (Compound 1) is an orally active agonist for somatostatin receptor type 5 (SST5) with EC50 <1 nM. Zavolosotine inhibits insulin and glucagon secretion, increases levels of glucagon in blood in rat model .
    Zavolosotine
  • HY-161705
    Anti-apoptotic agent 1

    		Apoptosis Neurological Disease
    Anti-apoptotic agent 1 (Compound B4) exhibits neuroprotective activity and good pharmacokinetic properties. Anti-apoptotic agent 1 inhibits apoptosis, prevents stroke recurrence in photothrombotic rat model .
    Anti-apoptotic agent 1
  • HY-W151617A
    Desethoxy Quetiapine dihydrochloride

    		Dopamine Receptor Neurological Disease
    Desethoxy Quetiapine dihydrochloride (Compound 28) is an antagonist for dopamine D2 receptor with an IC50 of 1330 nM. Desethoxy Quetiapine dihydrochloride antagonises Apomorphine (HY-12723)-induced climbing and swimming disruption in mouse models .
    Desethoxy Quetiapine dihydrochloride
  • HY-W979493
    TC-2216

    		nAChR Others
    TC-2216 is a compound with antidepressant and anxiolytic activity that has shown activity in multiple animal models and may exert its effects by acting on α4β2 neuronal nicotinic receptors.
    TC-2216
  • HY-144361
    Antitumor agent-44

    		Apoptosis Cancer
    Antitumor agent-44 (Compound 5n) disrupts the mitochondrial homeostasis, induces cell cycle arrest and apoptosis in human adenocarcinoma cells. Antitumor agent-44 (Compound 5n) possesses good anti-tumor activity in a lung-cancer-cell xenograft mice model .
    Antitumor agent-44
  • HY-W158160
    AGS1286 sodium

    		Bacterial Infection
    AGS1286 (sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate) is an organosulfur compound that serves as a model for investigating the impact of sulfur-containing compounds on enzymatic activities and metabolic pathways. Additionally, it has been employed to explore the regulatory effects of these compounds on bacterial growth and gene expression.
    AGS1286 sodium
  • HY-138969
    (±)10(11)-EDP ethanolamide

    10,11-EDP-EA; 10,11-EDP epoxide; 10,11-Epoxy docosapentaenoic ethanolamide

    		 Drug Derivative Others
    (±)10(11)-EDP ethanolamide (10,11-EDP-EA) (compound C) is an ω-3 endocannabinoid epoxide derivative with antiangiogenic, antitumor and anti-migratory properties in osteosarcoma models.
    (±)10(11)-EDP ethanolamide
  • HY-146615
    Axl-IN-6

    		TAM Receptor Cancer
    Axl-IN-6 (compound 14) is an orally active and potent AXL inhibitor. Axl-IN-6 is well tolerated and significantly inhibits the tumor growth in MV-4-11 subcutaneous xenograft model .
    Axl-IN-6
  • HY-131545
    Parogrelil

    NT-702 free base; NT-702 free base

    		 Phosphodiesterase (PDE) Others
    Parogrelil (NT-702 free base) is a compound with intermittent claudication inhibitory activity that inhibits PDE3, inhibits platelet aggregation and vasoconstriction, and improves walking distance and plantar surface temperature in a rat experimental model.
    Parogrelil
  • HY-157456
    RIPK1-IN-19

    		RIP kinase Inflammation/Immunology
    RIPK1-IN-19 (compound 10b) is a selective RIPK1 inhibitor (IC50=15 nM). RIPK1-IN-19 displays potent protective activity in TNFα-induced systemic inflammatory response syndrome (SIRS) model and Imiquimod (IMQ)-induced psoriasis model. RIPK1-IN-19 can be used in research on inflammation and immune system diseases .
    RIPK1-IN-19
  • HY-146465
    Anticancer agent 60

    		Microtubule/Tubulin Cancer
    Anticancer agent 60 (compound 3h) has antiproliferative activity against human HepG2 cells (IC50 = 4.13 μM) and presents antitumor efficacy in a human HepG2 xenograft mouse model .
    Anticancer agent 60
  • HY-162786
    Nurr1 agonist 11

    		Nuclear Hormone Receptor 4A/NR4A Neurological Disease
    Nurr1 agonist 11 (compound 53) is a selective and potent Nurr1 agonist with an IC50 of 26 µM. Nurr1 agonist 11 has the ability to cross a cellular model of the blood-brain-barrier (BBB) .
    Nurr1 agonist 11

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