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topoisomerase

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By Targets:	Topoisomerase (390) ADC Antibody (1) ADC Cytotoxin (49) Akt (2) AMPK (3) Androgen Receptor (1) Antibiotic (92) Antibody-Drug Conjugates (ADCs) (7) AP-1 (2) Apoptosis (101) ATM/ATR (1) Autophagy (51) Bacterial (106) Bcl-2 Family (1) Biochemical Assay Reagents (2) Btk (1) c-Myc (4) Casein Kinase (1) Caspase (4) Cathepsin (1) CD22 (1) Cholinesterase (ChE) (1) Cuproptosis (1) Cytochrome P450 (2) DNA-PK (2) DNA/RNA Synthesis (51) Drug Metabolite (3) Drug-Linker Conjugates for ADC (38) EGFR (7) Elastase (1) Endogenous Metabolite (16) ERK (2) Estrogen Receptor/ERR (1) FAK (2) Fatty Acid Synthase (FASN) (1) FLT3 (1) Fungal (11) GLUT (2) Glutathione Peroxidase (1) HBV (3) HDAC (2) HIV (6) HSP (2) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (4) Integrin (1) Interleukin Related (3) Isotope-Labeled Compounds (14) JNK (2) Keap1-Nrf2 (1) Lipoxygenase (1) MDM-2/p53 (1) MicroRNA (8) Microtubule/Tubulin (6) Mitochondrial Metabolism (8) Mitophagy (9) Molecular Glues (1) Monoamine Oxidase (2) Necroptosis (2) NF-κB (7) NO Synthase (2) Opioid Receptor (1) Orthopoxvirus (13) P2X Receptor (1) p38 MAPK (2) Parasite (18) PARP (1) Phosphatase (3) PI3K (3) PKC (7) Proteasome (3) Reactive Oxygen Species (17) Reverse Transcriptase (3) ROS Kinase (1) SARS-CoV (3) Sirtuin (3) STAT (2) TMV (1) TNF Receptor (1) TROP2 (1) VEGFR (2) Virus Protease (1) α-synuclein (1)
By Research Areas:	Cancer (390) Cardiovascular Disease (7) Infection (136) Inflammation/Immunology (20) Metabolic Disease (5) Neurological Disease (11)
Click Chemistry:	DBCO (2)
Oligonucleotides:	Cholesterol (1)

475

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

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Isotope-Labeled Compounds

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Oligonucleotides

Targets Recommended: Topoisomerase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W278582

Topoisomerase II inhibitor 14	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO .

HY-169106

Topoisomerase inhibitor 4	Topoisomerase Apoptosis	Cancer
Topoisomerase inhibitor 4 (compound 45) is a potent *Topoisomerase1/2* inhibitor. Topoisomerase inhibitor 4 causes cell cycle arrest in the G2/M phase by inducing Apoptosis. Topoisomerase inhibitor 4 has antitumor activity .

HY-149002

Topoisomerase I/II inhibitor 4	Topoisomerase Apoptosis	Cancer
Topoisomerase I/II inhibitor 4 (compound F16) is a potent topoisomerase I (Topo I) and II (Topo II) dual inhibitor. Topoisomerase I/II inhibitor 4 inhibits cell proliferation, invasion and migration and induces apoptosis. Topoisomerase I/II inhibitor 4 can be used for liver cancer research .

HY-156969

Topoisomerase I inhibitor 11	Topoisomerase Btk	Cancer
Topoisomerase I inhibitor 11 is a potent inhibitor of *Topoisomerase* I. Topoisomerase I inhibitor 11 can bind to BTK .

HY-146437

Topoisomerase I inhibitor 6	Topoisomerase	Cancer
Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases .

HY-162342

Topoisomerase I inhibitor 14	Topoisomerase	Cancer
Topoisomerase I inhibitor 14 (Compound 4h) is an inhibitor for Topoisomerase I. Topoisomerase I inhibitor 14 inhibits proliferation of A549 and C6 with IC₅₀s of 4.56 μM and 13.17 μM, without significant toxicity in healthy cells NIH3T3 (IC₅₀ is 74.44 μM), which exhibits anticancer potency .

HY-163118

Topoisomerase II inhibitor 17	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 17 (compound 4c) is an inhibitor of thiazolopyrimidine topoisomerase (Topoisomerase) Top II (IC₅₀: 0.23 μM). Topoisomerase II inhibitor 17 can significantly cause cell cycle disruption and apoptosis .

HY-149309

Topoisomerase inhibitor 2	Topoisomerase	Infection
Topoisomerase inhibitor 2 (18C) is a bacterial topoisomeraseinhibitor that exhibits potent broad-spectrum activity against multidrug-resistant Gram-negative bacteria .

HY-162381

Topoisomerase II inhibitor 19	Topoisomerase	Cancer
Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and topoisomerase II inhibitor (IC₅₀ value of 0.34 μM). Topoisomerase II inhibitor 19 would induce detectable potent damage in ctDNA .

HY-155645

Topoisomerase II inhibitor 15	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 15 (compound 2g) is a Topoisomerase II inhibitor. Topoisomerase II inhibitor 15 potently is an apoptotic inducer with greater selectivity against head and neck tumors .

HY-146497

Topoisomerase I inhibitor 7	Topoisomerase	Cancer
Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor agent candidates among the heteroarene-fused anthraquinones .

HY-162101

Topoisomerase inhibitor 3	Topoisomerase	Cancer
Topoisomerase inhibitor 3 (compound 9) is a potent *Topoisomerase* inhibitor. Topoisomerase inhibitor 3 shows antiproliferative and anti-tumor activity .

HY-147861

Topoisomerase II inhibitor 11	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC₅₀ of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC₅₀ of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity .

HY-146316

Topoisomerase II inhibitor 6	Topoisomerase	Cancer
Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases .

HY-155693

Topoisomerase II inhibitor 16	Topoisomerase Parasite	Infection
Topoisomerase II inhibitor 16 (compound CT3) is a selective, orally active, brain-penetrant and irreversible *trypanosomal topoisomerase* II** inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. Topoisomerase II inhibitor 16 has the potential for Chagas disease research .

HY-143265

Topoisomerase I inhibitor 2	Topoisomerase Apoptosis Caspase	Cancer
Topoisomerase I inhibitor 2 (ZML-8) is a highly selective inhibitor of *DNA topoisomerase* I (Top1*). Topoisomerase* I inhibitor 2 inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis, exhibits anti-tumor effect .

HY-152473

Topoisomerase IIα-IN-6	Topoisomerase	Cancer
Topoisomerase IIα-IN-6 (Compound 47d) is an inhibitor of *DNA topoisomerase* IIα/β*. Topoisomerase* IIα-IN-6 inhibits human topoisomerase IIα and human topoisomerase IIβ with IC₅₀ values of 0.67 µM and 0.55 µM, respectively. Topoisomerase IIα-IN-6 has stable metabolism .

HY-152187

Topoisomerase IIα-IN-5	Topoisomerase Apoptosis	Others
Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629) .

HY-152479

Topoisomerase IIα-IN-7	Topoisomerase	Cancer
Topoisomerase IIα-IN-7 is an *DNA topoisomerase* IIα inhibitor with an IC₅₀** value of 7.7 µM. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells. Topoisomerase IIα-IN-7 has metabolic stability .

HY-146020

Topoisomerase IIα-IN-1	Topoisomerase	Cancer
Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines .

HY-146021

Topoisomerase IIα-IN-2	Topoisomerase	Cancer
Topoisomerase IIα-IN-2 (compound 5) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-2 exhibits high antiproliferative activity against human cancer cell lines. Topoisomerase IIα-IN-2 significantly induces DNA damage and arrests cancer cells at G2/M phase .

HY-147801

Topoisomerase IIα-IN-3	Topoisomerase Apoptosis	Cancer
Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis .

HY-144774

Topoisomerase I inhibitor 5	Topoisomerase DNA/RNA Synthesis Apoptosis	Cancer
Topoisomerase I inhibitor 5 is an effective *topoisomerase* inhibitor with IC₅₀ value of. Topoisomerase I inhibitor 5 can interfere with DNA and significantly inhibit the activity of Topoisomerase I. Topoisomerase I inhibitor 5 can arrest cell cycle at the G1 phase and induce MCF-7 cells apoptosis. Topoisomerase I inhibitor 5 has potency in reversing P-gp-mediated resistance to Adriamycin .

HY-153401

Topoisomerase II inhibitor 13	Topoisomerase	Cancer
Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis .

HY-158061

Topoisomerase II inhibitor 20	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 20 (Compound 3e) is a potent topoisomerase II (Topoisomerase II) inhibitor with an IC₅₀ of 0.98 µM. Topoisomerase II inhibitor 20 induces apoptosis and has broad-spectrum anticancer activity .

HY-W031307

Topoisomerase IIα-IN-8	Topoisomerase	Cancer
Topoisomerase IIα-IN-8 (compound 15) is a weak *human DNA topoisomerase* IIa (htIIa) inhibitor, with an IC₅₀** of 462 ± 38.0 μM .

HY-148058

Topoisomerase I inhibitor 8	Topoisomerase	Cancer
Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells .

HY-143266

Topoisomerase I inhibitor 3	Topoisomerase Apoptosis	Cancer
Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase .

HY-147877

Topoisomerase II inhibitor 12	Topoisomerase	Cancer
Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity .

HY-156464

Topoisomerase I inhibitor 10	Topoisomerase	Infection
Topoisomerase I inhibitor 10 (compound 13) is a *leishmanial topoisomerase* IB** inhibitor. Topoisomerase I inhibitor 10 has antileishmanial activity against L. donovani promastigotes, with the IC₅₀ of 27.91 μM .

HY-161082

Topoisomerase I inhibitor 12	Topoisomerase	Cancer
Topoisomerase I inhibitor 12 (compound 12), a Camptothecin (HY-16560)-based derivative, is a potent Topoisomerase I inhibitor. Topoisomerase I inhibitor 12 shows anticancer activity .

HY-162341

Topoisomerase I inhibitor 15	Topoisomerase	Cancer
Topoisomerase I inhibitor 15 (compound 4b) is an inhibitor of topoisomerase I with anticancer activity. Topoisomerase I inhibitor 15 inhibits A549 cells with an IC₅₀ of 7.34 μM .

HY-151453

Topoisomerase IIα-IN-4	Topoisomerase Apoptosis	Cancer
Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive *human DNA topoisomerase* II inhibitor with an IC₅₀** value of 3.8 and 10.1 μM for TopoIIα and TopoIIβ, respectively. Topoisomerase IIα-IN-4 shows potent potency in apoptosis induction and cell cycle arrest in HepG2 cells. Topoisomerase IIα-IN-4 exhibits strong antitumor activities against human cancer cell lines, it can be used for the research of cancer .

HY-146163

Topoisomerase II inhibitor 7	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 7 (compound 3a) is a potent inhibitor of topoisomerase II alpha subtype, with an IC₅₀ of 3.19 μM. Topoisomerase II inhibitor 7 can induce cell cycle arrest and apoptosis .

HY-156462

Topoisomerase I inhibitor 9	Topoisomerase	Infection
Topoisomerase I inhibitor 9 (compound 3d) is a *leishmanial topoisomerase* IB** inhibitor. Topoisomerase I inhibitor 9 has antileishmanial activity against L. donovani promastigotes, with the IC₅₀ of 34.81μM .

HY-143281

Topoisomerase II inhibitor 5	Topoisomerase	Cancer
Topoisomerase II inhibitor 5 (Compound E24) is a DNA topoisomerase II inhibitor with anticancer activities .

HY-126333

Topoisomerase II inhibitor 1	Topoisomerase	Cancer
Topoisomerase II inhibitor 1 (compound 89) is a highly efficient and selective topoisomerase IIα inhibitor .

HY-162380

Topoisomerase II inhibitor 18	Topoisomerase	Cancer
Topoisomerase II inhibitor 18 (Compound IV) is a Quinoxaline derivative, which inhibits topoisomerase II with IC₅₀ of 7.5 μM. Topoisomerase II inhibitor 18 inhibits proliferation, cell cycle at S phase and induces apoptosis in PC-3 cells. Topoisomerase II inhibitor 18 reveals antitumor activity against cancer .

HY-157402

Topoisomerase II/EGFR-IN-1	Topoisomerase EGFR	Cancer
Topoisomerase II/EGFR-IN-1 is topoisomerase II/EGFR dual inhibitor. Topoisomerase II/EGFR-IN-1 has superior cytotoxic activity to MCF-7, A549 and HCT-116 cell lines, displays strong apoptotic activity and can be used for the research of cancer .

HY-143301

Topoisomerase I inhibitor 4	Topoisomerase	Cancer
Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC₅₀s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer .

HY-161385

Topoisomerase I inhibitor 16	Topoisomerase	Cancer
Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI₅₀ 39 nM .

HY-146188

Topoisomerase II inhibitor 8	Topoisomerase	Cancer
Topoisomerase II inhibitor 8 (compound 22) is a potent topoisomerase II inhibitor, with an IC₅₀ of 0.52 μM. Topoisomerase II inhibitor 8 exhibits good anti-proliferative activities and can arrest the cell cycle at G2/M phase .

HY-143280

Topoisomerase II inhibitor 4	Topoisomerase	Cancer
Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect .

HY-143402

Topoisomerase I/II inhibitor 2	Topoisomerase	Cancer
Topoisomerase I/II inhibitor 2 (compound 1a) is a potent *Topoisomerase* inhibitor (IC₅₀= 9.82 μM on Huh7 cells and 6.83 μM on LM9 cells). Topoisomerase I/II inhibitor 2 has dual inhibition on DNA topoisomerase I/II, also can obviously reduce the growth of xenograft tumor in mice model. Topoisomerase I/II inhibitor 2 has the potential value in researching liver cancer .

HY-147839

Topoisomerase II inhibitor 10	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 10 (compound 32a) is a potent topoisomerase II inhibitor with an IC₅₀ value of 7.45 μM. Topoisomerase II inhibitor 10 causes cell cycle arrest at G2-M phase and induces apoptosis of HepG-2 cells. Topoisomerase II inhibitor 10 has excellent anti-proliferative activities against HepG-2, MCF-7, and HCT-116 cells .

HY-162091

Topoisomerase I inhibitor 13	Topoisomerase	Cancer
Topoisomerase I inhibitor 13 (Compound G11) is a Topo I inhibitor that inhibits cancer cell proliferation. Topoisomerase I inhibitor 13 significantly inhibits tumor growth in vivo .

HY-146504

Topoisomerase I/II inhibitor 3	Topoisomerase PI3K Apoptosis Reactive Oxygen Species	Cancer
Topoisomerase I/II inhibitor 3 (compound 7) is a potent topoisomerase I (Topo I) and *II (Topo* II)** dual inhibitor. Topoisomerase I/II inhibitor 3 can inhibit cell proliferation, invasion and migration, and induce apoptosis by inhibiting PI3K/Akt/mTOR signaling pathway. Topoisomerase I/II inhibitor 3 can be used for liver cancer research .

HY-146189

Topoisomerase II inhibitor 9	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 9 (Compound 19b) is a Topo II inhibitor with an IC₅₀ of 0.97 μM. Topoisomerase II inhibitor 9 is also a classical DNA-intercalator with an IC₅₀ of 43.51 μM. Topoisomerase II inhibitor 9 arrests the cell cycle at the G2/M phase and induces apoptosis in Hep G‐2 cells .

HY-115990

Topoisomerase IV inhibitor 1	Topoisomerase Bacterial	Infection
Topoisomerase IV inhibitor 2 (compound 7d) is a potent *DNA topoisomerase* IV (TOPO IV) inhibitor with IC₅₀*s of 0.23 μM and 0.43 μM for TOPO* IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 0.972 μM and 0.608 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively .

HY-115991

Topoisomerase IV inhibitor 2	Topoisomerase Bacterial	Infection
Topoisomerase IV inhibitor 2 (compound 5d) is a potent *DNA topoisomerase* IV (TOPO IV) inhibitor with IC₅₀*s of 0.35 μM and 0.55 μM for TOPO* IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 1.985 μM and 0.744 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively .

Cat. No.	Product Name	Type

HY-13631AG

Exatecan (mesylate) (GMP) DX8951f (GMP)	Fluorescent Dye
Exatecan mesylate (DX8951f ) GMP is a GMP-class Exatecan (HY-13631). Exatecan is a *DNA topoisomerase* I inhibitor, with an IC₅₀** of 2.2 μM (0.975 μg/mL), and can be used in cancer research .

HY-N2306

Aclacinomycin A 3 Publications Verification Aclarubicin	Fluorescent Dyes/Probes
Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-N2306R

Aclacinomycin A (Standard)

Fluorescent Dyes/Probes

Aclacinomycin A (Standard) is the analytical standard of Aclacinomycin A. This product is intended for research and analytical applications. Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-16700G

PNU-159682 (GMP)	Fluorescent Dye
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

Cat. No.	Product Name	Type

HY-13631AG

Exatecan (mesylate) (GMP) DX8951f (GMP)	Biochemical Assay Reagents
Exatecan mesylate (DX8951f ) GMP is a GMP-class Exatecan (HY-13631). Exatecan is a *DNA topoisomerase* I inhibitor, with an IC₅₀** of 2.2 μM (0.975 μg/mL), and can be used in cancer research .

HY-16700G

PNU-159682 (GMP)	Biochemical Assay Reagents
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

Cat. No.	Product Name	Target	Research Area

HY-164152

ADC Control Human IgG1-Deruxtecan (DAR 4)	Antibody-Drug Conjugates (ADCs) Topoisomerase	Cancer
ADC Control Human IgG1-Deruxtecan (DAR 4) is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-Deruxtecan and can inhibit *DNA topoisomerase* I**. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E) .

HY-P99813

Patritumab deruxtecan HER3-DXd; U3-1402	Antibody-Drug Conjugates (ADCs)	Cancer
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity .

HY-P99843

Datopotamab	TROP2 ADC Antibody	Cancer
Datopotamab (CDP7657) is a humanized anti trophoblast cell surface antigen 2 (TROP2) antibody. Datopotamab can generate antibody drug conjugates (ADC) (HY-141598) with DNA topoisomerase I inhibitor Deruxtecan (HY-13631E). Datopotamab can be used in the study of triple negative breast cancer and non-small cell lung cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6880

Rabdosiin (+)-Rabdosiin	Structural Classification Classification of Application Fields Labiatae Lignans Phenylpropanoids Balsamorhiza macrophylla Nutt. Plants Inflammation/Immunology Disease Research Fields	HIV Topoisomerase
Rabdosiin is a tetramer of caffeic acid isolated from the stem of Ocimum sanctum. Rabdosiin possess anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase .

HY-N3488

Isodiospyrin	Quinones Structural Classification other families Diospyros virginiana L. Source classification Benzene Quinones Plants	Topoisomerase Bacterial Fungal
Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities .

HY-N0872

Isosteviol (-)-Isosteviol; iso-Steviol	Structural Classification other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Cancer	Interleukin Related Reactive Oxygen Species Topoisomerase
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-116933

Murrayanol	Alkaloids Structural Classification Rutaceae Murraya koenigii (L.) Spreng Plants Indole Alkaloids	Topoisomerase Bacterial
Murrayanol is a natural carbazole alkaloid with a variety of biological activities. Murrayanol shows anti-inflammatory, topoisomerase I and topoisomerase II (Topoisomerase) inhibition activities. Murrayanol also as a mosquitocidal and antimicrobial .

HY-124552

Epolactaene	Structural Classification Natural Products Microorganisms Source classification	DNA/RNA Synthesis Topoisomerase
Epolactaene is a potent Topoisomerase II and DNA Polymerase inhibitor with IC₅₀ values of 10, 25, 94 µM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively .

HY-N10367

Corydamine	Alkaloids Corydalis bulleyana Diels Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer	Topoisomerase
Corydamine, 3-arylisoquinoline alkaloid, is a potent *DNA topoisomerase* I/II** inhibitor. Corydamine has anti-cancer activity .

HY-N12129

6,6′-Dihydroxythiobinupharidine	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Plants Nuphar pumila (Timm) de Candolle Nymphaeaceae	Cathepsin
6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively .

HY-N6054

Niranthin	Infection Classification of Application Fields Phyllanthus amarus chumacher & Thonning Source classification Lignans Euphorbiaceae Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Parasite Topoisomerase
Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.

HY-N6054R

Niranthin (Standard)	Phyllanthus amarus chumacher & Thonning Source classification Lignans Euphorbiaceae Phenylpropanoids Plants	Parasite Topoisomerase
Niranthin (Standard) is the analytical standard of Niranthin. This product is intended for research and analytical applications. Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.

HY-N0872R

Isosteviol (Standard)	Structural Classification other families Terpenoids Source classification Diterpenoids Plants	Interleukin Related Reactive Oxygen Species Topoisomerase
Isosteviol (Standard) is the analytical standard of Isosteviol. This product is intended for research and analytical applications. Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-N10495

Seconeolitsine	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Fields	Antibiotic Bacterial Topoisomerase
Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC₅₀ value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics .

HY-16560

Camptothecin 35+ Cited Publications Campathecin; (S)-(+)-Camptothecin; CPT	Infection Structural Classification Alkaloids Classification of Application Fields Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields	Topoisomerase ADC Cytotoxin MicroRNA Influenza Virus Apoptosis Fungal Antibiotic
Camptothecin (CPT), a kind of alkaloid, is a *DNA topoisomerase* I (Topo I) inhibitor with an IC₅₀ of 679 nM . Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA)** expression patterns in human cancer cells .

HY-19825

Rebeccamycin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	Topoisomerase ADC Cytotoxin Antibiotic
Rebeccamycin, an antitumor antibiotic, inhibits *DNA topoisomerase* I*. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase* I and has negligible effect on protein kinase C and topoisomerase II .

HY-N0354

Anthraquinone	Seeds of Cassia tora Linn. Quinones Structural Classification other families Classification of Application Fields Leguminosae Anthraquinones Source classification Other Diseases Plants Disease Research Fields	Virus Protease Topoisomerase Apoptosis
Anthraquinone is used as a precursor for dye formation and agrochemicals, existing in different organisms, such as bacteria, fungi, plants, and some animals. Anthraquinone has biological activities: anticancer, antiinflammatory, diuretic, antiarthritic, antifungal, antibacterial, antimalarial and antioxidant. Anthraquinone also plays an important role in the primary metabolism of plants by acting on the electron transport chain through the inhibition of energy transfer in the photosynthetic process. Anthraquinone can intercalates into DNA and inhibits the topoisomerase II (topo II) enzyme, resulting in cell death via Apoptosis .

HY-123589

Gyramide A	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	Others
Gyramide A is a compound mentioned in the study of the protective effect of Qnr protein on bacterial topoisomerase. Qnr has no protective effect on it, and its activity is different from that of other topoisomerase inhibitors.

HY-N6800A

Netropsin dihydrochloride	Classification of Application Fields Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis Bacterial Influenza Virus Antibiotic Orthopoxvirus
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei . Netropsin dihydrochloride exhibits antiviral activity against the vaccinia virus .

HY-121309

Doxorubicinone Adriamycin aglycone; Adriamycinone	Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human *DNA topoisomerase* I and topoisomerase II inhibitor with IC₅₀**s of 0.8 μM and 2.67 μM, respectively.

HY-119458

Luotonin A	Structural Classification Alkaloids Peganum nigellastrum Bunge Zygophyllaceae Source classification Quinoline Alkaloids Plants	Topoisomerase TMV Fungal
Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity .

HY-15552

Podofilox 3 Publications Verification Podophyllotoxin	Structural Classification Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Microtubule/Tubulin
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-13768A

Topotecan hydrochloride 25+ Cited Publications SKF 104864A hydrochloride; NSC 609669 hydrochloride	Alkaloids Structural Classification Monophenols Classification of Application Fields Source classification Phenols Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Cancer	Topoisomerase Autophagy Apoptosis
Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.

HY-N10115

Huanglongmycin N	Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields Cancer	Topoisomerase
Huanglongmycin N is a *DNA topoisomerase* I inhibitor (EC₅₀** = 14 μM).

HY-N6714

Alternariol	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis
Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

HY-N8473

Pericosine A (+)-Pericosine A	Structural Classification Natural Products Microorganisms Source classification	Topoisomerase
Pericosine A ((+)-Pericosine A) is a topoisomerase II (Topoisomerase II) inhibitor that can be isolated from the Periconia byssoides strain. Pericosine A has significant antitumor activity in vitro and in vivo and can be used in cancer research. Pericosine A also inhibits the protein kinase epidermal growth factor receptor .

HY-15753

Ellipticine 3 Publications Verification NSC 71795	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits *DNA topoisomerase* II** activities.

HY-15753A

Ellipticine hydrochloride 3 Publications Verification NSC 71795 hydrochloride	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Amsonia elliptica (Thunberg ex Murray) Roemer & Schultes Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits *DNA topoisomerase* II** activities.

HY-16562A

Irinotecan hydrochloride 40+ Cited Publications (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; VAL-413	Alkaloids Structural Classification Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Cancer	Topoisomerase Autophagy
Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-N2331

Proscillaridin A	Apocynaceae Structural Classification Classification of Application Fields Source classification Nerium indicum Mill. Plants Disease Research Fields Steroids Cancer	Topoisomerase
Proscillaridin A is a potent poison of topoisomerase I/II activity with IC₅₀ values of 30 nM and 100 nM, respectively .

HY-121309R

Doxorubicinone (Standard)	Quinones Structural Classification Anthraquinones Source classification Endogenous metabolite	Endogenous Metabolite
Doxorubicinone (Standard) is the analytical standard of Doxorubicinone. This product is intended for research and analytical applications. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.

HY-100309

9-Aminocamptothecin 1 Publications Verification 9-Amino-20(S)-camptothecin; 9-Amino-CPT	Alkaloids Structural Classification Classification of Application Fields Source classification Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Indole Alkaloids Cancer	Topoisomerase
9-Aminocamptothecin (9-Amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity .

HY-N0275

(±)-10-Hydroxycamptothecin (±)-10-HCPT	Structural Classification Pyrrole Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Alkaloids Monophenols Phenols Disease Research Fields Cancer	Topoisomerase
(±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.

HY-N5038

Mauritianin	Flavonols Classification of Application Fields Source classification Erythrina stricta Roxb. Plants Compositae Acalypha indica Linn. Flavonoids Phenols Polyphenols Euphorbiaceae Disease Research Fields Cancer	Topoisomerase
Mauritianin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica. Mauritianin is a topoisomerase I inhibitor .

HY-N12747

Dichlorogelignate	Structural Classification Source classification Phenols Polyphenols Plants Boraginaceae Arnebia euchroma (Royle) Johnst.	Topoisomerase
Dichlorogelignate (compound 4) is a selective inhibitor of topoisomerase II (Topo II). Dichlorogelignate has 100% inhibition at 50 μM .

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 422 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Disease Research Fields	Topoisomerase ADC Cytotoxin AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial
Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human *DNA topoisomerase* I** and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-18258

Berberine chloride 40+ Cited Publications Natural Yellow 18 chloride	Alkaloids Structural Classification Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite Parasite
Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-N9500

Ganoderic acid X	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Apoptosis Topoisomerase
Ganoderic acid X is a lanostanoid triterpene that can be extracted from Ganoderma amboinense. Ganoderic acid X inhibits *topoisomerases* and induces apoptosis of cancer cells .

HY-13768AR

Topotecan hydrochloride (Standard)	Alkaloids Structural Classification Monophenols Source classification Phenols Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants	Topoisomerase Autophagy Apoptosis
Topotecan (hydrochloride) (Standard) is the analytical standard of Topotecan (hydrochloride). This product is intended for research and analytical applications. Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.

HY-15552R

Podofilox (Standard)	Structural Classification Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae	Microtubule/Tubulin
Podofilox (Standard) is the analytical standard of Podofilox. This product is intended for research and analytical applications. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-17577

Berberine chloride hydrate 40+ Cited Publications Natural Yellow 18 chloride hydrate	Alkaloids Structural Classification Classification of Application Fields Source classification Ranunculaceae Coptis chinensis Franch. Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite Parasite
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-N8745

α-Peltatin	Structural Classification Podophyllum peltatum L. Source classification Lignans Phenylpropanoids Plants Berberidaceae	Fungal
α-Peltatin is an aryl lignan. α-Peltatin has anticancer and antifungal activity. α-Peltatin inhibits DNA topoisomerase and tubulin polymerization .

HY-15142A

Doxorubicin Hydroxydaunorubicin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	ADC Cytotoxin Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV
Doxorubicin (Hydroxydaunorubicin), a broad-spectrum anthracycline antibiotic with cytotoxic properties, is an anti-cancer chemotherapy agent. Doxorubicin has fluorescence properties. Doxorubicin inhibits topoisomerase II with an IC₅₀ of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy . Doxorubicin inhibits human *DNA topoisomerase* I with an IC₅₀** of 0.8 μM .

HY-15142R

Doxorubicin hydrochloride (Standard) 1 Publications Verification	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Topoisomerase ADC Cytotoxin AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial
Doxorubicin (hydrochloride) (Standard) is the analytical standard of Doxorubicin (hydrochloride). This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human *DNA topoisomerase* I** and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-N6621

Hippeastrine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Narcissus tazetta Linn. var. chinensis M.Roemer Source classification Plants Disease Research Fields Amaryllidaceae Cancer	Topoisomerase
Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC₅₀ at 7.25 μg/mL. Antiproliferative and anticancer activities .

HY-N2063

12-Ethyl-9-hydroxycamptothecin	Alkaloids Structural Classification Monophenols other families Pyrrole Alkaloids Classification of Application Fields Source classification Other Diseases Phenols Quinoline Alkaloids Plants Disease Research Fields	Topoisomerase
12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM .

HY-N2198

Podocarpusflavone A	Structural Classification Flavonoids Classification of Application Fields Guttiferae Source classification Phenols Polyphenols Plants Garcinia subelliptica Biflavones Disease Research Fields Cancer	Topoisomerase Apoptosis
Podocarpusflavone A is a DNA topoisomerase I inhibitor. Podocarpusflavone A has moderated anti-proliferative activity and induces cell apoptosis in MCF-7. Podocarpusflavone A is developing anti-tumor agents .

HY-N2331R

Proscillaridin A (Standard)	Apocynaceae Structural Classification Source classification Nerium indicum Mill. Plants Steroids	Topoisomerase
Proscillaridin A (Standard) is the analytical standard of Proscillaridin A. This product is intended for research and analytical applications. Proscillaridin A is a potent poison of topoisomerase I/II activity with IC₅₀ values of 30 nM and 100 nM, respectively .

HY-13555

β-Lapachone 5+ Cited Publications ARQ-501; NSC-26326	Quinones Structural Classification other families Classification of Application Fields Source classification Plants Naphthalene Quinones Disease Research Fields Cancer	Indoleamine 2,3-Dioxygenase (IDO) Topoisomerase Autophagy Apoptosis
β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.

HY-122550

Artemisitene 1 Publications Verification	Piscidia erythrina L. Terpenoids Sesquiterpenes Source classification Plants Compositae	Keap1-Nrf2 Topoisomerase Apoptosis
Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability .

HY-10529

Betulinic acid 20+ Cited Publications Lupatic acid; Betulic acid	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties .

HY-N6621A

Hippeastrine hydrobromide	Structural Classification Natural Products Source classification Plants Amaryllidaceae Pancratium canariense Ker Gawl.	Topoisomerase
Hippeastrine hydrobromide is an active alkaloid that exhibits a good dose-dependent inhibitory effect on topoisomerase I (Top I) with an IC₅₀ of 7.25?μg/mL. Hippeastrine hydrobromide exhibits antiproliferative and anticancer activities .

HY-118726

Luotonin F	Structural Classification Alkaloids Peganum nigellastrum Bunge Zygophyllaceae Source classification Quinoline Alkaloids Plants	Topoisomerase
Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II .

Recombinant Proteins Recommended:

Topoisomerase

Species:	Virus (1) Human (2) E.coli (2)
Tag:	His (3) Tag Free (1)
Source:	Sf9 insect cells (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P73584

	TOP1 Protein, Human (765a.a, sf9, His) DNA topoisomerase 1; TOP1	Human	Sf9 insect cells
	The TOP1 protein is critical in cellular processes, mitigating DNA supercoiling and torsional tension during replication and transcription. It does this by transiently cutting and rejoining a DNA strand, introducing breaks through transesterification. TOP1 Protein, Human (765a.a, sf9, His) is the recombinant human-derived TOP1 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of TOP1 Protein, Human (765a.a, sf9, His) is 765 a.a., with molecular weight of ~93.1 kDa.

HY-P73585

	TOP1 Protein, Human (575a.a, sf9, His) DNA topoisomerase 1; TOP1	Human	Sf9 insect cells
	The TOP1 protein is critical in cellular processes, mitigating DNA supercoiling and torsional tension during replication and transcription. It does this by transiently cutting and rejoining a DNA strand, introducing breaks through transesterification. TOP1 Protein, Human (575a.a, sf9, His) is the recombinant human-derived TOP1 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of TOP1 Protein, Human (575a.a, sf9, His) is 575 a.a., with molecular weight of ~70.4 kDa.

HY-P701907

	gyrB Protein, E.coli gyrB; DNA gyrase subunit B; Type IIA topoisomerase subunit GyrB	E.coli	E. coli
	The GyrB protein negatively supercoils DNA, making it more accessible to topoisomerase 4. gyrB Protein, E.coli is the recombinant E. coli-derived gyrB protein, expressed by E. coli , with tag free. The total length of gyrB Protein, E.coli is 391 a.a., .

HY-P701908

	gyrB Protein, E.coli (His) gyrB; DNA gyrase subunit B; Type IIA topoisomerase subunit GyrB	E.coli	E. coli
	The GyrB protein negatively supercoils DNA, making it more accessible to topoisomerase 4. gyrB Protein, E.coli (His) is the recombinant E. coli-derived gyrB protein, expressed by E. coli , with N-6*His labeled tag. The total length of gyrB Protein, E.coli (His) is 391 a.a., .

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Species
Source
Tag
Accession
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Molecular Weight
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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-16562S1

Irinotecan-d10 hydrochloride
Irinotecan-d₁₀ (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1][2].

HY-13631AS

Exatecan-d5 mesylate
Exatecan-d₅ (mesylate) is deuterium labeled Exatecan mesylate. Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL[1].

HY-13566AS

Belotecan-d7 hydrochloride
Belotecan-d₇ (hydrochloride) is the deuterium labeled Belotecan hydrochloride. Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative[1][2].

HY-13562AS

Banoxantrone-d12 dihydrochloride
Banoxantrone-d₁₂ (dihydrochloride) is the deuterium labeled Banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

HY-16562S

Irinotecan-d10
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1].

HY-121309S

Doxorubicinone-d3
Doxorubicinone-d₃ is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.

HY-15552S

Podofilox-d6
Podofilox-d₆ is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II[1][2].

HY-10581AS

Gatifloxacin-d3 hydrochloride

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

HY-16562AS

Irinotecan-d5 hydrochloride
Irinotecan-d₅ hydrochloride is deuterated labeled Irinotecan hydrochloride (HY-16562A). Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-13562S

Banoxantrone-d12
Banoxantrone-d₁₂ is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

HY-18258S

Berberine-d6 chloride
Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties[1].

HY-B0526S

Flumequine-13C3
Flumequine- ¹³C₃ is the ¹³C₃ labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).

HY-13502S

Mitoxantrone-d8
Mitoxantrone-d₈ (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM[1][2].

HY-13631DS

Dxd-d5
Dxd-d₅ is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) [1].

HY-W015490S

1,4-Naphthoquinone-d6
1,4-Naphthoquinone-d₆ is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].

HY-126373S1

SN-38 glucuronide-13C6
SN-38 glucuronide- ¹³C₆ is the ¹³C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .

HY-13629S1

Etoposide-13C,d3
Etoposide- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoposide. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy[1].

HY-13629S

Etoposide-d3
Etoposide-d3 (VP-16-d3) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-B0398S

Nalidixic Acid-d5

Nalidixic Acid-d₅ is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1].

HY-13704S

SN-38-d3
SN-38-d₃ is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].

HY-145397S

(4-NH2)-Exatecan-d5
(4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan . (4-NH2)-Exatecan (compound A), a *topoisomerase* inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-13768S1

Topotecan-d6
Topotecan-d₆ is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87[1][2].

HY-16560S

Camptothecin-d5

Camptothecin-d₅ is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].

HY-13502AS

Mitoxantrone-d8 dihydrochloride

Mitoxantrone-d₈ dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-B0268S1

Enoxacin-d8 hydrochloride

Enoxacin-d₈ (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing[1][2][3][4].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82492

	Topoisomerase I Antibody (YA2237) TOP1; DNA topoisomerase 1; DNA topoisomerase I	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Topoisomerase I Antibody (YA2237) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2237), targeting Topoisomerase I, with a predicted molecular weight of 91 kDa (observed band size: 91 kDa). Topoisomerase I Antibody (YA2237) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P80980

	TOP2A Antibody DNA topoisomerase II; DNA topoisomerase II-alpha; TOP2; TP2A; alpha isozyme, topoisomerase II alpha	WB, IHC-P, IP	Human, Mouse, Rat
	TOP2A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 174 kDa, targeting to TOP2A. It can be used for WB, IHC-P, IP assays with tag free, in the background of Human, Mouse, Rat.

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Cat. No.	Product Name		Classification

HY-134723

DBCO-PEG4-GGFG-Dxd		DBCO
DBCO-PEG4-GGFG-Dxd is a agent-linker conjugate for ADC with potent antitumor activity by using Dxd (a DNA topoisomerase I inhibitor), linked via the cleavable ADC linker DBCO-PEG4-GGFG . DBCO-PEG4-GGFG-Dxd is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-164792

DBCO-PEG3-VC-Exatecan		DBCO
DBCO-PEG3-VC-Exatecan (compound 25) is a Drug-Linker Conjugate for ADC. DBCO-PEG3-VC-Exatecan contains the ADC linker (DBCO-PEG3-VC) and a *DNA topoisomerase* I** inhibitor Exatecan (HY-13631) .

Cat. No.	Product Name		Classification

HY-W010800

Cholesteryl hemisuccinate		Cholesterol
Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth .

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