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Results for "

cyclic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cyclic GMP-AMP Synthase (15) HCN Channel (15) 5 alpha Reductase (1) 5-HT Receptor (3) ADC Cytotoxin (3) ADC Linker (7) Adenosine Deaminase (2) Adenosine Receptor (4) Adenylate Cyclase (4) Adrenergic Receptor (5) Amino Acid Derivatives (5) AMPK (2) Amylin Receptor (1) Amyloid-β (1) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (18) Apoptosis (26) Arp2/3 Complex (3) Atg8/LC3 (1) Autophagy (3) Bacterial (33) Bcl-2 Family (1) Beta-lactamase (2) Beta-secretase (2) Biochemical Assay Reagents (27) Bradykinin Receptor (1) c-Myc (1) Calcium Channel (14) Calmodulin (2) Cannabinoid Receptor (1) Carbonic Anhydrase (1) Caspase (4) CD38 (1) CFTR (1) Chloride Channel (1) CMV (1) Complement System (3) COX (1) CRFR (1) CXCR (4) Cyclophilin (1) DNA/RNA Synthesis (7) Drug Derivative (2) Drug Metabolite (4) Drug-Linker Conjugates for ADC (1) EBV (2) EGFR (3) Elastase (2) Endogenous Metabolite (64) Endonuclease (1) Epigenetic Reader Domain (1) ERK (7) Estrogen Receptor/ERR (1) Factor Xa (1) Ferroptosis (1) Fluorescent Dye (9) Fungal (10) GABA Receptor (2) GLP Receptor (1) Glycoprotein VI (1) Guanylate Cyclase (7) HBV (1) HDAC (3) Herbicide (1) HIF/HIF Prolyl-Hydroxylase (2) Histamine Receptor (1) HIV (1) HIV Protease (1) HSV (2) IFNAR (4) IGF-1R (2) iGluR (6) Influenza Virus (4) Insulin Receptor (1) Integrin (11) IRAK (1) Isotope-Labeled Compounds (22) JAK (1) JNK (2) LAG-3 (1) LDLR (1) MARCKS (1) MDM-2/p53 (3) Melanocortin Receptor (3) mGluR (1) Microtubule/Tubulin (2) Mitophagy (2) MMP (4) Neurokinin Receptor (3) NF-κB (4) NO Synthase (9) Notch (1) Nucleoside Antimetabolite/Analog (5) Opioid Receptor (2) Orthopoxvirus (1) Oxytocin Receptor (2) P2X Receptor (1) P2Y Receptor (2) p62 (1) Parasite (5) PCSK9 (1) Phosphodiesterase (PDE) (80) Phospholipase (1) PI3K (3) PKA (31) PKC (4) PKG (10) Potassium Channel (6) PPAR (1) Prostaglandin Receptor (4) PROTAC Linkers (2) Proteasome (4) Radionuclide-Drug Conjugates (RDCs) (2) Raf (3) Ras (6) Reactive Oxygen Species (4) Renin (1) SARS-CoV (2) Ser/Thr Protease (3) Sigma Receptor (1) Sirtuin (1) Somatostatin Receptor (9) STING (33) TNF Receptor (7) Toll-like Receptor (TLR) (1) Trk Receptor (2) TRP Channel (4) Tyrosinase (1) Urotensin Receptor (1) Vasopressin Receptor (1) Virus Protease (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (147) Cardiovascular Disease (75) Endocrinology (32) Infection (69) Inflammation/Immunology (106) Metabolic Disease (68) Neurological Disease (87)
Click Chemistry:	PROTAC Synthesis (2) Azide (1) Alkynes (3)
Oligonucleotides:	Nucleoside Phosphoramidites (2) Phospholipids (1)

540

Inhibitors & Agonists

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172

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120

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Oligonucleotides

Cyclic AMP sodium 5+ Cited Publications cyclic adenosine monophosphate sodium; Adenosine cyclic 3', 5'-monophosphate sodium; cAMP sodium; cyclic AMP sodium	Biochemical Assay Reagents	Neurological Disease Metabolic Disease Cancer
Cyclic AMP (Cyclic adenosine monophosphate) sodium, adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP sodium is an important second messenger in many biological processes .

Cyclic N-Acetyl-D-mannosamine cyclic ManNAc	Endogenous Metabolite	Metabolic Disease
Cyclic N-Acetyl-D-mannosamine (Cyclic ManNAc) is an endogenous metabolite.

Cyclic AMP 5+ Cited Publications cyclic adenosine monophosphate; Adenosine cyclic 3', 5'-monophosphate; cAMP	Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .

Cyclic AMP (Standard) cyclic adenosine monophosphate (Standard); Adenosine cyclic 3', 5'-monophosphate (Standard); cAMP (Standard)	Endogenous Metabolite	Cancer
Cyclic AMP (Standard) is the analytical standard of Cyclic AMP. Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes .

Cyclic GMP sodium 1 Publications Verification	Endogenous Metabolite	Inflammation/Immunology
Cyclic GMP sodium (cGMP) is an important regulator of short-term changes in smooth muscle tone and longer-term responses to chronic drug research or proliferative signals, it is in response to atrial natriuretic peptide (ANP) or nitric oxide (NO). Cyclic GMP sodium interacts with cation channels to regulate ion transport or activate the cyclic GMP-dependent protein kinase to result in protein phosphorylation .

c-di-AMP cyclic diadenylate; cyclic-di-AMP	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

Cyclic L27-11	Bacterial	Infection
Cyclic L27-11 is a cyclic peptide-like antibiotic with strong antibacterial activity against specific bacteria such as Pseudomonas sp. Cyclic L27-11 shows nanomolar antibacterial activity against Pseudomonas sp., especially Pseudomonas aeruginosa. Cyclic L27-11 interferes with the function of bacterial outer membrane protein LptD, preventing the normal transport of lipopolysaccharide (LPS), leading to the accumulation of membrane-like substances in bacterial cells, which in turn affects the survival of bacteria. Cyclic L27-11 can be used in the development of antibacterial agents .

cAIMP cyclic Adenosine-Inosine Monophosphate	NF-κB IFNAR	Inflammation/Immunology
cAIMP (Cyclic Adenosine-Inosine Monophosphate) is an effective synthetic cyclic dinucleotide. cAIMP activates IRF and NF-κB in the THP1 human monocyte reporter cell line (THP1-Dual). cAIMP induces the secretion of IFNs and pro-inflammatory cytokines in vitro in human blood, with an EC₅₀ of 6.4 μmol/L .

Cyclic MKEY	CXCR	Cardiovascular Disease Cancer
Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice .

Cyclic HPMPC	CMV Orthopoxvirus	Infection
Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model .

Cyclic tri-AMP	Endonuclease	Infection
Cyclic tri-AMP is a component of the cyclic oligonucleotide-based anti-phage signaling system (CBASS), and acts as the second messenger in the immune response against viral infection. Cyclic tri-AMP binds to and activates DNA endonuclease NucC, results in cell death and exhibits antiviral activity .

Cyclic GMP (TBAOH) 1 Publications Verification	Others	Cancer
Cyclic GMP TBAOH is a tetra-n-butylammonium hydroxide (TBAOH) form of Cyclic GMP (HY-12512). Cyclic GMP is an endogenous second messenger that regulates a variety of cellular processes including apoptosis, vasodilation, and neurotransmission through the activation of signaling pathways such as Protein Kinase G in cells .

Cyclic AC253	Amylin Receptor	Neurological Disease
Cyclic AC253 is an antagonist for amylin receptor, with IC₅₀ of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB) .

Cyclic MKEY TFA	CXCR	Cardiovascular Disease Cancer
Cyclic MKEY TFA is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY TFA also protects against stroke-induced brain injury in mice .

Cyclic SSTR agonist octreotide	Somatostatin Receptor	Others
Cyclic SSTR agonist octreotide is a Octreotide (HY-P0036), serving as the cyclic Somatostatin Receptor SSTR agonist .

Cyclic GMP 1 Publications Verification	STING Endogenous Metabolite	Inflammation/Immunology
Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators .

Cyclic-di-GMP c-di-GMP; cyclic diguanylate; 5GP-5GP	STING Endogenous Metabolite	Cancer
Cyclic-di-GMP is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP can be used in cancer research .

Cyclic-di-GMP sodium c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium	STING Endogenous Metabolite	Cancer
Cyclic-di-GMP sodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research .

Cyclic AMP-13C5 cyclic adenosine monophosphate-¹³C₅; Adenosine cyclic 3', 5'-monophosphate-¹³C₅; cAMP-¹³C₅	Isotope-Labeled Compounds	Others
Cyclic AMP- ¹³C₅ is a deuterated cyclic AMP.

Cyclic ADP-ribose cADPR	Calcium Channel TRP Channel Endogenous Metabolite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

cSPM cyclic spermine	Amyloid-β	Neurological Disease
cSPM (Cyclic spermine) is a Aβ42 inhibitor. cSPM could suppress the aggregation of three different peptides, Aβ42, amylin and insulin, and decreases cytotoxicity .

Cyclic-di-GMP diammonium 5 Publications Verification c-di-GMP diammonium; cyclic diguanylate diammonium; 5GP-5GP diammonium	STING Endogenous Metabolite	Cancer
Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research .

Cyclic-di-GMP disodium 5 Publications Verification c-di-GMP disodium; cyclic diguanylate disodium; 5GP-5GP disodium	STING Endogenous Metabolite	Cancer
Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research .

Cyclic GMP-13C,15N2 Guanosine 3',5'-cyclic-¹³C,¹⁵N₂ monophosphate	Isotope-Labeled Compounds STING Endogenous Metabolite	Inflammation/Immunology
Cyclic GMP- ¹³C, ¹⁵N₂ is ¹³C and ¹⁵N labeled Cyclic GMP. Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators .

Cyclic ADP-ribose ammonium cADPR ammonium	Calcium Channel TRP Channel Endogenous Metabolite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

C-di-IMP cyclic-di-IMP	STING	Cancer
C-di-IMP (Cyclic-di-IMP) is a STING agonist. C-di-IMP can be used for the research of tumor .

c-di-AMP diammonium 2 Publications Verification cyclic diadenylate diammonium; cyclic-di-AMP diammonium	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

Cyclic(YCDGFYACYMDV)	EGFR Apoptosis	Cancer
Cyclic(YCDGFYACYMDV) is a HER2 signaling pathway inhibitor with anti-cancer activity. This compound self-assembles into nanoparticles in aqueous solution and transforms into nanofibers upon specific binding to HER2 on cancer cells. This transformation disrupts HER2 dimerization and subsequent downstream signaling events, leading to cancer cell apoptosis (Apoptosis). The inhibitory effects on HER2 positive breast cancer have been demonstrated to be effective in a murine xenograft model .

c-di-AMP disodium 2 Publications Verification cyclic diadenylate disodium; cyclic-di-AMP disodium	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

cGAMP 10+ Cited Publications cyclic GMP-AMP; 3',3'-cGAMP	STING	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

cGAMP disodium 10+ Cited Publications cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

cGAMP diammonium 10+ Cited Publications cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

Pifithrin-β PFT β; cyclic Pifithrin-α	MDM-2/p53	Cancer
Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC₅₀ of 23 μM.

C-di-IMP disodium cyclic-di-IMP disodium	STING	Cancer
C-di-IMP disodium is a STING agonist. C-di-IMP disodium can be used in tumor research .

Pifithrin-β hydrobromide 10+ Cited Publications PFT β hydrobromide; cyclic Pifithrin-α hydrobromide	MDM-2/p53 Ferroptosis	Cancer
Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC₅₀ of 23 μM.

1,1-Dioxothiolan-d8 Bondelane A-d₈; cyclic tetramethylene sulfone-d₈; Cyclotetramethylene sulfone-d₈	Isotope-Labeled Compounds	Others
1,1-Dioxothiolan-d₈ is the deuterium labeled 1,1-Dioxothiolan[1].

SFTI-1	Ser/Thr Protease	Others
SFTI-1 is a cyclic peptide trypsin inhibitor comprising 14 amino acid residues. SFTI-1 is a potent Bowman-Birk inhibitor.

2'-O-MB-cAMP sodium 2'-O-Monobutyryl cyclic AMP sodium	Others	Others
2'-O-MB-cAMP (2'-O-Monobutyryl cyclic AM) sodium is an activatable proagent of Cyclic AMP (HY-B1511) .

2',3'-cUMP sodium Uridine-2', 3'-cyclic monophosphate sodium salt	Others	Others
2',3'-cUMP sodium (Uridine-2', 3'-cyclic monophosphate sodium salt) is a competitive inhibitor of dip-nitrophenyl diphosphate hydrolysis .

*8-CPT-Cyclic* AMP sodium** 8-CPT-cAMP sodium; 8-(p-Chlorophenylthio)-cAMP sodium	PKA Phosphodiesterase (PDE)	Inflammation/Immunology
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). 8-CPT-Cyclic AMP sodium is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC₅₀ of 0.9 μM. 8-CPT-Cyclic AMP sodium also inhibits PDE III and PDE IV with IC₅₀Cyclic AMP sodium is a very high affinity for Epac and is a potent Epac activator .

*Adenosine 2',3'-cyclic* phosphate**	Endogenous Metabolite	Metabolic Disease
Adenosine 2',3'-cyclic phosphate is a 2',3'-cyclic purine nucleotide. Adenosine 2',3'-cyclic phosphate can be degrade to 2'-AMP and 3'-AMP .

SEI144	Biochemical Assay Reagents	Others
SEI144 is a low nanomolar binder of USP15 and does not inhibit USP15 activity .

*Adenosine 2',3'-cyclic* phosphate sodium**	Endogenous Metabolite	Metabolic Disease
Adenosine 2',3'-cyclic phosphate sodium is a 2',3'-cyclic purine nucleotide, which can be degrade to 2'-AMP and 3'-AMP .

CTTHWGFTLC, CYCLIC	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC₅₀ value for MMP-9 is ~8 μM .

*CTTHWGFTLC, CYCLIC* TFA**	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC₅₀ value for MMP-9 is ~8 μM .

*Capecitabine-2',3'-cyclic* carbonate (Standard)**	Others	Cancer
Capecitabine-2',3'-cyclic carbonate (Standard) is the analytical standard of Capecitabine-2',3'-cyclic carbonate. This product is intended for research and analytical applications. Capecitabine-2',3'-cyclic carbonate (Compd 5a) is a 5'-deoxy-5-fluorocytidine derivative with anticancer activity .

Cat. No.	Product Name

HY-L110

Cyclic Peptide Library

92 compounds

Cyclic peptides are polypeptide chains taking cyclic ring structure, which exhibit diverse biological activities, such as antibacterial activity, immunosuppressive activity and anti-tumor activity. Cyclic peptides, with the features of good binding affinity, target selectivity and low toxicity, show great success as therapeutics. Multiple cyclic peptides are currently in clinical use, for examples, gramicidin and tyrocidine with bactericidal activity, cyclosporin A with immunosuppressive activity, and vancomycin with antibacterial activity. Furthermore, cyclic peptides usually have the sufficient size and a balanced conformational flexibility/rigidity for binding to flat protein-protein interaction (PPI) interfaces, which have potential to develop PPI drugs.

MCE offers a unique collection of 92 cyclic peptides, all of which have good bioactivities. MCE Cyclic Peptide Library is a powerful tool for drug discovery and PPI inhibitor screening.

HY-L071

Alkaloids Library

556 compounds

Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds.

MCE designs a unique collection of 556 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

HY-L138

Heterocyclic Compound Library

6,185 compounds

Heterocyclic compounds are cyclic organic compounds which contain at least one hetero atom, the most common heteroatoms are nitrogen, oxygen ,and sulfur. Heterocycles are common in biology, featuring a wide range of structures from enzyme co-factors to amino acids and proteins. On the one hand, heterocycles are common structural units in approved drugs and in medicinal chemistry targets in the drug discovery process. In addition, heterocycles have been found as a key structure in medical chemistry and also they are frequently found in large percent of biomolecules such as vitamins, natural products ,and biologically active compounds including antifungal, anti-inflammatory, antibacterial, antioxidant, antiallergic, anti-HIV, antidiabetic, anticancer activity.

MCE offers a unique collection of 6,185 heterocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE heterocyclic compound library is critical for drug discovery and development.

Cat. No.	Product Name	Type

HY-D1177

Solvent orange 60	Dyes
Solvent orange 60 is a cyclic ketone dye commonly used in plastic materials such as eyeglass frames and has been shown to cause contact allergies.

HY-D2475

2-Amino-5-methoxybenzamidoxime	Fluorescent Dyes/Probes
2-Amino-5-methoxybenzamidoxime is a chemical probe for detection of ketone, including aromatic ketones, hydroxyl ketones, cyclic ketones and aliphatic ketones. 2-Amino-5-methoxybenzamidoxime exhibits an excitation maximal wavelength of 389 nm and a emission maximal wavelength of 515 nm .

HY-D2379

HMRG

Fluorescent Dyes/Probes

HMRG is a type of hydroxymethyl rhodamine green fluorescent scaffold, featuring an open non-cyclic structure. HMRG can produce significant dynamic fluorescence changes through a one-step enzymatic reaction at physiological pH, which is useful for developing various probes. Fluorescent probes based on HMRG can be used for fluorescence detection of diseases such as tumors and diabetic nephropathy .

Cat. No.	Product Name	Type

HY-B1511A

Cyclic AMP sodium 5+ Cited Publications cyclic adenosine monophosphate sodium; Adenosine cyclic 3', 5'-monophosphate sodium; cAMP sodium; cyclic AMP sodium	Biochemical Assay Reagents
Cyclic AMP (Cyclic adenosine monophosphate) sodium, adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP sodium is an important second messenger in many biological processes .

HY-W133891

Peptone from soya

Peptones, soybean

Biochemical Assay Reagents

Peptone from soya (Peptones, soybean) is a peptone that is commonly used as a component of culture medium. Peptone from soya can be used in microbiology and cell culture to provide needed sources of nitrogen, carbon and other nutrients. Peptone from soya stimulates/regulates cyclic arachidonic acid biosynthesis. Peptone from soya also exerts enteric cell activity in jejunum of piglets through this mechanism .

HY-Y1275

N-Methylpyrrolidone NMP; 1-Methyl-2-pyrrolidinone	Co-solvents
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an organic polar solvent. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-Y0531

1-Adamantanol 1-Adamantanol	Biochemical Assay Reagents
1-Adamantanol is a cyclic molecule with a hydroxyl group that can be used as an intermediate in the synthesis of adamantane. 1-Adamantanol can be oxidized to 1,3-adamantanediol by the Streptomyces SA8 oxidation system .

HY-44134

Dimethyl 2-oxoglutarate Dimethyl α-ketoglutarate	Biochemical Assay Reagents
Dimethyl 2-oxoglutarate serves as a crucial intermediate in the Krebs cycle and an essential nitrogen carrier in metabolic pathways during biological processes. The electrochemical behavior of Dimethyl 2-oxoglutarate can be investigated using cyclic voltammetry, square wave voltammetry, and differential pulse voltammetry with a glassy carbon electrode .

HY-131755

*2'-Deoxyadenosine 3':5'-cyclic* monophosphate sodium**	Enzyme Substrates
2'-Deoxyadenosine 3':5'-cyclic monophosphate (sodium) is a kind of biochemical reagent.

HY-W411889

α-D-Mannofuranose, cyclic 2,3-carbonate

Carbohydrates

α-D-Mannofuranose, cyclic 2,3-carbonate is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W776928

α-D-Mannopyranoside,methyl 4,6-O-(1-methylethylidene),cyclic carbonate

Carbohydrates

α-D-Mannopyranoside,methyl 4,6-O-(1-methylethylidene),cyclic carbonate is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W099747

Valericanhydride	Biochemical Assay Reagents
Valericanhydride is an organic compound, a cyclic anhydride, derived from valeric acid.

HY-166519

(2-Hydroxypropyl)-α-cyclodextrin (MW 1180) α‐HPCD (MW 1180)	Co-solvents
(2-Hydroxypropyl)-α-cyclodextrin (MW 1180) is a cyclic oligosaccharide derivative that acts as a solubilizer in various experiments.

HY-101461

Methyl-β-cyclodextrin Maximum Cited Publications 50 Publications Verification Methyl-beta-cyclodextrin	Co-solvents
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent . Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis . Methyl-β-cyclodextrin blocks cell migrasome formation .

HY-W051391

1,4,7-Trimethyl-1,4,7-triazonane

Me3TACN

Biochemical Assay Reagents

1,4,7-Trimethyl-1,4,7-triazonane, also known as TMT or trimethylenetris(aziridine), is a cyclic organic compound. TMT is commonly used as a crosslinking agent and a precursor for polymer and resin synthesis. In addition, it is used as a stabilizer in the production of polyurethane foam and as a curing agent for epoxy resins. Due to its high reactivity and stability, TMT is considered to be a versatile and efficient reagent in various applications.

HY-Y0842

Formamide

Methanamide; Formimidic acid

Co-solvents

Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. It induces apoptosis by promoting the formation of cyclic nucleotides and the phosphorylation and dephosphorylation processes of nucleotides, making it useful in cancer research. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers.

HY-W250154

β-Nicotinamide adenine dinucleotide reduced dipotassium

Biochemical Assay Reagents

β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle .

HY-137234

DM-β-CD

2,6-Di-O-methyl-β-cyclodextrin

Co-solvents

DM-β-CD (2,6-Di-O-methyl-β-cyclodextrin) is a cyclic molecule consisting of seven glucose units modified with two methyl groups at the 2- and 6-positions. It is usually used as a solubilizer and carrier for poorly soluble drugs in pharmaceutical preparations. Furthermore, it has applications in analytical chemistry, food science, and environmental remediation due to its ability to form clathrates with various guest molecules, such as aromatic compounds, pesticides, and heavy metals.

HY-Y0842R

Formamide (Standard)

Co-solvents

Formamide (Standard) is the analytical standard of Formamide. This product is intended for research and analytical applications. Formamide is an effective DNA denaturant that significantly reduces the stability of DNA in buffer solutions. It induces apoptosis by promoting the formation of cyclic nucleotides and the phosphorylation and dephosphorylation processes of nucleotides, making it useful in cancer research. Formamide can also be used as a decalcifying agent for rat cardiac cells. Additionally, formamide is widely used as a solvent or chemical raw material for ion compounds, resins, and plasticizers. [4]

HY-104086

Cucurbit[7]uril

1 Publications Verification

CB7; Carrier CB7

Drug Delivery

Cucurbit[7]uril is a cyclic organic molecule consisting of seven glycoluril units linked by methylene bridges. It has a rigid barrel-like structure with two identical inlets at both ends to selectively encapsulate guest molecules of appropriate size, shape, and polarity. Cucurbit[7]uril is known for its high binding affinity for a variety of organic and inorganic guests, including drugs, amino acids, peptides, and metal ions. This property makes them promising candidates for various applications in areas such as drug delivery, catalysis, and sensing.

HY-W021265

Cyclohexane-1,2,3,4,5,6-hexaol

Cyclohexane-1,2,3,4,5,6-hexol

Biochemical Assay Reagents

Cyclohexane-1,2,3,4,5,6-hexaol, also known as inositol or inositol, is a cyclic sugar alcohol consisting of a six-carbon ring with six hydroxyl groups. This compound is important for its biological activity and is widely distributed in nature, especially in plant and animal tissues. It plays a role in various physiological processes such as signal transduction, osmoregulation and lipid metabolism. In addition, Cyclohexane-1,2,3,4,5,6-hexaol has potential investigational effects, including improving conditions related to insulin resistance, polycystic ovary syndrome, and mental health conditions. It can also be used as a supplement in animal feed and human nutritional products.

HY-W035133

5,10,15,20-Tetrakis(p-tolyl)porphyrin

5,10,15,20-Tetra-p-tolyl-21H,23H-porphine

Biochemical Assay Reagents

5,10,15,20-Tetrakis(p-tolyl)porphyrin (TTP) is an organic compound belonging to the class of porphyrins, a cyclic molecule composed of four pyrrole rings linked together. TTP is a synthetic porphyrin commonly used as a sensitizer for dye-sensitized solar cells and a catalyst for organic reactions. Due to its unique structure, TTP has a series of interesting properties, including at specific wavelengths and its potential as a catalyst for various chemical reactions. In dye-sensitized solar cells, TTPs help convert sunlight into electricity by absorbing photons and transferring electrons to the semiconductor layer of the device. In organic chemistry, TTP is often used as a catalyst for various organic compounds in reactions such as oxidation and reduction. Its ability to selectively bind certain substrates makes it a useful tool for synthesizing complex molecules and studying their properties.

Cat. No.	Product Name	Target	Research Area

HY-P3193A

Cyclic nona-L-arginine hydrochloride	Peptides	Others
Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P10235

Cyclic AC253	Amylin Receptor	Neurological Disease
Cyclic AC253 is an antagonist for amylin receptor, with IC₅₀ of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB) .

HY-P1949A

Cyclic MKEY TFA	CXCR	Cardiovascular Disease Cancer
Cyclic MKEY TFA is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY TFA also protects against stroke-induced brain injury in mice .

HY-P0084

Cyclic somatostatin SRIF-14; Somatostatin-14	Peptides	Cardiovascular Disease Neurological Disease
Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC₅₀ value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease .

HY-P4102

Cyclic PSAP peptide	Peptides	Cancer
Cyclic PSAP peptide is a cyclic pentapeptide (DWLPK). Cyclic PSAP peptide exhibits agent-like properties and could inhibit metastatic spread and restrain tumor development in general in vivo .

HY-P3193

Cyclic nona-L-arginine TFA	Peptides	Others
Cyclic nona-L-arginine TFA, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

HY-P10548

Cyclic L27-11	Bacterial	Infection
Cyclic L27-11 is a cyclic peptide-like antibiotic with strong antibacterial activity against specific bacteria such as Pseudomonas sp. Cyclic L27-11 shows nanomolar antibacterial activity against Pseudomonas sp., especially Pseudomonas aeruginosa. Cyclic L27-11 interferes with the function of bacterial outer membrane protein LptD, preventing the normal transport of lipopolysaccharide (LPS), leading to the accumulation of membrane-like substances in bacterial cells, which in turn affects the survival of bacteria. Cyclic L27-11 can be used in the development of antibacterial agents .

HY-P0084R

Cyclic somatostatin (Standard)	Peptides	Cardiovascular Disease Neurological Disease
Cyclic somatostatin (Standard) is the analytical standard of Cyclic somatostatin. This product is intended for research and analytical applications. Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease .

HY-P1949

Cyclic MKEY	CXCR	Cardiovascular Disease Cancer
Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice .

HY-P4100

Cyclic SSTR agonist octreotide	Somatostatin Receptor	Others
Cyclic SSTR agonist octreotide is a Octreotide (HY-P0036), serving as the cyclic Somatostatin Receptor SSTR agonist .

HY-P10793

Cyclic(YCDGFYACYMDV)	EGFR Apoptosis	Cancer
Cyclic(YCDGFYACYMDV) is a HER2 signaling pathway inhibitor with anti-cancer activity. This compound self-assembles into nanoparticles in aqueous solution and transforms into nanofibers upon specific binding to HER2 on cancer cells. This transformation disrupts HER2 dimerization and subsequent downstream signaling events, leading to cancer cell apoptosis (Apoptosis). The inhibitory effects on HER2 positive breast cancer have been demonstrated to be effective in a murine xenograft model .

HY-P10033

SFTI-1	Ser/Thr Protease	Others
SFTI-1 is a cyclic peptide trypsin inhibitor comprising 14 amino acid residues. SFTI-1 is a potent Bowman-Birk inhibitor.

HY-P10672

SEI144	Biochemical Assay Reagents	Others
SEI144 is a low nanomolar binder of USP15 and does not inhibit USP15 activity .

HY-P1789

CTTHWGFTLC, CYCLIC	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC₅₀ value for MMP-9 is ~8 μM .

HY-P1789A

*CTTHWGFTLC, CYCLIC* TFA**	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC₅₀ value for MMP-9 is ~8 μM .

HY-P10027

Clovibactin	Antibiotic Bacterial	Infection
Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

HY-P10027A

Clovibactin TFA	Antibiotic Bacterial	Infection
Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

HY-P10835

*LAG-3 cyclic* peptide inhibitor C25**	LAG-3	Cancer
LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with human LAG-3 protein with a K_d value of 0.66 μM. LAG-3 cyclic peptide inhibitor C25 can block the interaction of LAG-3 with HLA-DR (MHC-II) and activate CD8 ⁺ T cells. LAG-3 cyclic peptide inhibitor C25 can be used in the study of cancer .

HY-P1206

CH 275	Somatostatin Receptor	Neurological Disease
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM . CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively . CH 275 can be used for the research of alzheimer’s disease .

HY-P10383A

*SPSB2-iNOS inhibitory cyclic* peptide-1 TFA**	Peptides	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-1(HY-P10383). SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

HY-P10384A

*SPSB2-iNOS inhibitory cyclic* peptide-2 TFA**	Peptides	Infection
SPSB2-iNOS inhibitory cyclic peptide-2 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-2 (HY-P10384). SPSB2-iNOS inhibitory cyclic peptide-2 TFA is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 21 nM. SPSB2-iNOS inhibitory cyclic peptide-2 TFA is reduction-resistant and oxidatively stable .

HY-P10383

*SPSB2-iNOS inhibitory cyclic* peptide-1**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

HY-P10385A

*SPSB2-iNOS inhibitory cyclic* peptide-3 TFA**	Peptides	Infection
SPSB2-iNOS inhibitory cyclic peptide-3 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-3 (HY-P10385). SPSB2-iNOS inhibitory cyclic peptide-3 TFA is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 7 nM .

HY-P10384

*SPSB2-iNOS inhibitory cyclic* peptide-2**	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-2 (Compound CP2) is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 21 nM. SPSB2-iNOS inhibitory cyclic peptide-2 is reduction-resistant and oxidatively stable .

HY-P5217

CSTSMLKAC (disulfide)	Peptides	Others
CSTSMLKAC (peptide 2) is a *cyclic* 9 amino acid sequence that mimics endogenous peptide sequences. CSTSMLKAC homes to cardiomyocytes in the ischemic myocardium .

HY-P2202

Desferriferribactin	Bacterial	Others
Desferriferribactin is a cyclic peptide containing a thirteen-membered ring. Desferriferribactin is a precursor of pyoverdins .

HY-P5957

Omphalotin A	Parasite	Infection
Omphalotin A is a cyclic peptide, and shows nematicidal activity .

HY-P3145

Astin A	Peptides	Cancer
Astin A is an antitumor cyclic pentapeptide. Astin A can be isolated from Aster tataricus .

HY-133801

Unguisin A	Peptides	Others
Unguisin A s a cyclic peptides that can be isolated from the marine-derived fungus Emericella unguis .

HY-125488

Unguisin B	Peptides	Others
Unguisin B s a cyclic peptides that can be isolated from the marine-derived fungus Emericella unguis .

HY-P10385

*SPSB2-iNOS inhibitory cyclic* peptide-3**	Peptides	Infection
SPSB2-iNOS inhibitory cyclic peptide-3 (Compound CP3) is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 7 nM .

HY-35028

Boc-Glu-Ofm	Amino Acid Derivatives	Others
Boc-Glu-Ofm is a peptide. Boc-Glu-Ofm has been used for the synthesis of ester insulin and cyclic peptide mixtures .

HY-P3557

Mibenratide	Adrenergic Receptor	Cardiovascular Disease
Mibenratide, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide can be used for heart failure research .

HY-P3557A

Mibenratide TFA	Adrenergic Receptor	Cardiovascular Disease
Mibenratide TFA, a small cyclic peptide, is an adrenergic β1 receptor antagonist. Mibenratide TFA can be used for heart failure research .

HY-P1680

Astin C Asterin	Peptides	Inflammation/Immunology Cancer
Astin C (Asterin) is a cyclic pentapeptide with anticancer and anti-inflammatory properties .

HY-125357

Ternatin	Peptides	Metabolic Disease
Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC₅₀ of 0.027 μM in 3T3-L1 adipocytes .

HY-P3929

PKI (14-24)amide	PKA	Cancer
PKI (14-24)amide is a potent PKA inhibitor. PKI (14-24)amide strongly inhibited cyclic AMP-dependent protein kinase activity in the cell homogenate .

HY-P3929A

PKI (14-24)amide TFA	PKA	Cancer
PKI (14-24)amide TFA is a potent PKA inhibitor. PKI (14-24)amide strongly inhibited cyclic AMP-dependent protein kinase activity in the cell homogenate .

HY-W036160

N-Fmoc-O-ethyl-L-homoserine	Amino Acid Derivatives	Others
N-Fmoc-O-ethyl-L-homoserine is an homoserine derivative, can be used in cyclic peptide compounds synthesis, as a reducing reagent .

HY-P10812

CP61	Peptides	Cancer
CP61, a cyclic peptide, is a dual CtBP1/CtBP2 inhibitor. CP61 binds CtBP1 with 3 μM affinity. CP61 inhibits the heterodimerization and homodimerization of CtBP2 with an IC₅₀ value of 19 μM. CP61 is promising for research of cancers .

HY-P10557

DAG peptide	Peptides	Neurological Disease
DAG peptide is a cyclic peptide. DAG peptide selectively recognizes a subset of astrocytes that are activated in Alzheimer's disease (AD) starting at an early stage of the disease. DAG peptide can be used as a tool to enhance the delivery of therapeutics and imaging agents to sites of vascular changes and astrogliosis in diseases associated with neuroinflammation .

HY-P2171

CCP peptide	Peptides	Inflammation/Immunology
CCP peptide is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) .

HY-B1811

Vasopressin Maximum Cited Publications 12 Publications Verification	Endogenous Metabolite	Neurological Disease
Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors .

HY-P2171A

CCP peptide TFA	Peptides	Inflammation/Immunology
CCP peptide TFA is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide TFA functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) .

HY-P3777

β-Bag cell peptide	Potassium Channel	Neurological Disease
β-Bag cell peptide is a neuroactive peptide. β-Bag cell peptide elevates cyclic AMP levels in the bag cell neurons. β-Bag cell peptide decreases the amplitudes of the voltage-dependent potassium currents .

HY-P4012

[Asu1,6-Arg8]Vasopressin	Vasopressin Receptor	Endocrinology
[Asu1,6-Arg8]Vasopressin is an vasopressin agonist which potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasing factor (CRF) in rat anterior pituitary cells in culture .

HY-P2698

1-Alaninechlamydocin	HDAC Apoptosis	Cancer
1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC₅₀=6.4 nM). 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells .

HY-P10697

VH4127	LDLR	Metabolic Disease
VH4127 is a cyclic peptide targeting the low density lipoprotein receptor (LDLR) with a K_D of 18 nM for hLDLR. VH4127, bearing non-natural amino acid residues, specifically binds to rodent and human epidermal growth factor (EGF) homology domain of LDLR .

HY-P1178

Cyclotraxin B 3 Publications Verification	Trk Receptor	Neurological Disease
Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-P1178A

Cyclotraxin B TFA	Trk Receptor	Neurological Disease
Cyclotraxin B TFA, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B TFA non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B TFA can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

Cat. No.	Product Name	Target	Research Area

HY-P990037

Erzotabart	CD38	Cancer
Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity .

Species:	Human (20) Mouse (4) Rat (4) Cynomolgus (1) Rabbit (1)
Tag:	His (23) SUMO (1) Tag Free (2) Avi (1) Myc (1) GST (3) Fc (5)
Source:	HEK293 (17) Sf9 insect cells (4) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P70022

	CD38 Protein, Human (HEK293, Fc) rHuADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Fc; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, Fc) is the recombinant human-derived CD38 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD38 Protein, Human (HEK293, Fc) is 258 a.a., with molecular weight of 75-90 kDa.

HY-P70044

	CD38 Protein, Mouse (HEK293, Fc) rMuADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Fc; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10	Mouse	HEK293
	CD38 protein is pivotal in synthesizing crucial second messengers, cyclic ADP-ribose (cADPR) and nicotinate-adenine dinucleotide phosphate (NAADP). cADPR participates in glucose-induced insulin secretion, and NAADP functions as a calcium mobilizer. CD38 also displays cADPR hydrolase activity, showcasing its multifunctionality. CD38 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD38 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD38 Protein, Mouse (HEK293, Fc) is 260 a.a., with molecular weight of 70-90 kDa.

HY-P70074

	CD38 Protein, Cynomolgus (HEK293, His) rCynADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, His; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10	Cynomolgus	HEK293
	The CD38 protein plays multifaceted roles in cell signaling and is critical for the synthesis of cyclic ADP-ribose (cADPR) as a possible second messenger in glucose-induced insulin secretion. CD38 also promotes calcium mobilization through the synthesis of niacin adenine dinucleotide phosphate (NAADP+) and exhibits cADPR hydrolase activity. CD38 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD38 Protein, Cynomolgus (HEK293, His) is 258 a.a., with molecular weight of 38-50 kDa.

HY-P70731

	CD38 Protein, Human (HEK293, His, solution) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase 1; CD38 antigen; CD38 molecule; CD38	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, His, solution) is the recombinant human-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70731A

	CD38 Protein, Human (HEK293, C-His) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase 1; CD38 antigen; CD38 molecule; CD38	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, C-His) is the recombinant human-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD38 Protein, Human (HEK293, C-His) is 258 a.a., with molecular weight of 38-50 kDa.

HY-P76205

	CD157 Protein, Rat (HEK293, His) ADP-ribosyl cyclase; BST1; cyclic ADP-ribose hydrolase 2; CD157	Rat	HEK293
	CD157 protein catalyzes the synthesis of cADPR from NAD(+) and hydrolyzes cADPR to ADPR. cADPR acts as a second messenger, releasing calcium from intracellular stores. CD157 protein may also contribute to pre-B cell growth. CD157 Protein, Rat (HEK293, His) is the recombinant rat-derived CD157 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74647

	PDE2A Protein, Human (sf9, His) cGMP-dependent 3',5'-cyclic phosphodiesterase; CGS-PDE; PDE2A	Human	Sf9 insect cells
	PDE2A is a cGMP-activated cyclic nucleotide phosphodiesterase that exhibits dual specificity for the second messengers cAMP and cGMP, key regulators in various physiological processes. PDE2A exhibits higher efficiency by covering cAMP and plays an important role in cell growth and migration. PDE2A Protein, Human (sf9, His) is the recombinant human-derived PDE2A protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of PDE2A Protein, Human (sf9, His) is 686 a.a., with molecular weight of ~80.73 kDa.

HY-P75963

	PDE9A Protein, Human (His) High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; PDE9A	Human	E. coli
	PDE9A is a phosphodiesterase that uniquely hydrolyzes second messengers with unparalleled specificity, particularly in the regulation of natriuretic peptide-dependent signaling in the heart, which is critical for the control of cardiac hypertrophy. Its specificity rules out effects on nitric oxide-dependent signaling in the heart. PDE9A Protein, Human (His) is the recombinant human-derived PDE9A protein, expressed by E. coli , with N-His labeled tag. The total length of PDE9A Protein, Human (His) is 326 a.a., with molecular weight of ~37 kDa.

HY-P701960

	PDE4D Protein, Human PDE4D; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4D; DPDE3; PDE43	Human	E. coli
	PDE4D (Phosphodiesterase 4D) protein, as a hydrolytic enzyme, degrades the second messenger cAMP, a crucial regulator in various physiological processes. Its enzymatic activity in breaking down cAMP underscores PDE4D's pivotal role in modulating cellular signaling cascades, maintaining the intricate balance of intracellular communication mediated by this critical second messenger. PDE4D Protein, Human is the recombinant human-derived PDE4D protein, expressed by E. coli , with tag free. The total length of PDE4D Protein, Human is 328 a.a., .

HY-P76204

	CD157 Protein, Rat (HEK293, Fc) ADP-ribosyl cyclase; BST1; cyclic ADP-ribose hydrolase 2; CD157	Rat	HEK293
	CD157 protein catalyzes the synthesis of cADPR from NAD(+) and hydrolyzes cADPR to ADPR. cADPR acts as a second messenger, releasing calcium from intracellular stores. CD157 protein may also contribute to pre-B cell growth. CD157 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD157 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P701961

	PDE4D Protein, Human (His) PDE4D; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4D; DPDE3; PDE43	Human	E. coli
	PDE4D (Phosphodiesterase 4D) protein, as a hydrolytic enzyme, degrades the second messenger cAMP, a crucial regulator in various physiological processes. Its enzymatic activity in breaking down cAMP underscores PDE4D's pivotal role in modulating cellular signaling cascades, maintaining the intricate balance of intracellular communication mediated by this critical second messenger. PDE4D Protein, Human (His) is the recombinant human-derived PDE4D protein, expressed by E. coli , with N-6*His labeled tag. The total length of PDE4D Protein, Human (His) is 328 a.a., .

HY-P70892

	IL-17RA Protein, Human (HEK293, His) ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; CD38; T10	Human	HEK293
	IL-17RA (Interleukin 17 receptor A), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed ubiquitously and exhibits a broad tissue distribution, and plays a role in many inflammatory and autoimmune diseases. IL-17RA is a common co-receptor subunit for other members of the IL-17 family. IL-17RA associates with IL-17RC to form a signaling receptor complex for IL-17A and IL-17F. IL-17RA Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags.

HY-P75961

	PDE3A Protein, Human (sf9, His-GST) cGMP-inhibited 3',5'-cyclic phosphodiesterase A; CGI-PDE A; PDE3A	Human	Sf9 insect cells
	PDE3A protein, a cyclic nucleotide phosphodiesterase, targets cAMP, cGMP, and cUMP, crucial in diverse physiological processes. In an E2/17beta-estradiol-induced pro-apoptotic pathway, E2 stabilizes the PDE3A/SLFN12 complex, leading to SLFN12 dephosphorylation and activating its pro-apoptotic ribonuclease activity. This pathway is implicated in tissues with high E2 concentrations, potentially contributing to processes like placenta remodeling. PDE3A Protein, Human (sf9, His-GST) is the recombinant human-derived PDE3A protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of PDE3A Protein, Human (sf9, His-GST) is 473 a.a., with molecular weight of ~93 kDa.

HY-P75962

	PDE9A Protein, Human (sf9, His-GST) High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; PDE9A	Human	Sf9 insect cells
	PDE9A is a phosphodiesterase that uniquely hydrolyzes second messengers with unparalleled specificity, particularly in the regulation of natriuretic peptide-dependent signaling in the heart, which is critical for the control of cardiac hypertrophy. Its specificity rules out effects on nitric oxide-dependent signaling in the heart. PDE9A Protein, Human (sf9, His-GST) is the recombinant human-derived PDE9A protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of PDE9A Protein, Human (sf9, His-GST) is 533 a.a., with molecular weight of ~75 kDa.

HY-P76284

	CREB3L1 Protein, Human (HEK293, His) cyclic AMP-responsive element-binding protein 3-like protein 1; OASIS	Human	HEK293
	CREB3L1 protein is located on the endoplasmic reticulum membrane and is converted into a transcription factor processing cyclic AMP response element binding protein 3-like protein 1. During endoplasmic reticulum stress or DNA damage, it translocates to the Golgi apparatus, is cleaved by S1P/MBTPS1 and S2P/MBTPS2, and releases a cytoplasmic domain that activates gene transcription in the nucleus. CREB3L1 Protein, Human (HEK293, His) is the recombinant human-derived CREB3L1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72732

	CD38 Protein, Mouse (HEK293, His) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; T10; CD38	Mouse	HEK293
	CD38 protein is pivotal in synthesizing crucial second messengers, cyclic ADP-ribose (cADPR) and nicotinate-adenine dinucleotide phosphate (NAADP). cADPR participates in glucose-induced insulin secretion, and NAADP functions as a calcium mobilizer. CD38 also displays cADPR hydrolase activity, showcasing its multifunctionality. CD38 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD38 Protein, Mouse (HEK293, His) is 260 a.a., with molecular weight of 38-47 kDa.

HY-P7615

	ATF1 Protein, Human (His) rHuATF1, His; cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1	Human	E. coli
	ATF1 Protein, Human (His) expressed in E. coli with a His tag. ATF1 is a member of the ATF/CREB family of transcription factors (TFs), specifically interacting with the consensus ATF/CRE site ‘TGACGTCA’.

HY-P72896

	CD38 Protein, Rabbit (HEK293, His) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; ADPRC 1; CD38	Rabbit	HEK293
	CD38 protein performs diverse functions, synthesizing cyclic ADP-ribose (cADPR) for glucose-induced insulin secretion. It produces nicotinate-adenine dinucleotide phosphate (NAADP+), mobilizing calcium ions through 2'-phospho-cADPR and nicotinic acid, along with NADP+ and nicotinic acid. Additionally, CD38 acts as a cADPR hydrolase. CD38 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived CD38 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD38 Protein, Rabbit (HEK293, His) is 256 a.a., with molecular weight of 33-49 kDa.

HY-P72897

	CD38 Protein, Rat (HEK293, Fc) ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; ADPRC 1; CD38	Rat	HEK293
	CD38 protein plays diverse roles, synthesizing key second messengers: cyclic ADP-ribose (cADPR) for glucose-induced insulin secretion and nicotinate-adenine dinucleotide phosphate (NAADP) as a calcium mobilizer.Its cADPR hydrolase activity adds to its versatility.Notably, CD38 also regulates osteoclastic bone resorption, likely by producing cADPR and initiating a calcium ion signal through ryanodine receptor activation.CD38 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD38 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71591

	cGB-PDE Protein, Mouse (Myc, His) Pde5a; Pde5; cGMP-specific 3',5'-cyclic phosphodiesterase; EC 3.1.4.35; cGMP-binding cGMP-specific phosphodiesterase; CGB-PDE	Mouse	E. coli
	cGB-PDE protein regulates signal transduction by specifically hydrolyzing cto 5'-GMP, thereby controlling the intracellular concentration of cyclic nucleotides, particularly nitric-oxide-generated cGMP. cGB-PDE Protein, Mouse (Myc, His) is the recombinant mouse-derived cGB-PDE protein, expressed by E. coli , with N-His, C-Myc labeled tag.

HY-P75960

	PDE1B Protein, Human (sf9, His-GST) Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; Cam-PDE 1B; PDE1B1; PDES1B	Human	Sf9 insect cells
	PDE1B protein, a cyclic nucleotide phosphodiesterase, displays dual specificity for cAMP and cGMP, essential second messengers in physiological processes. Preferring cGMP as a substrate, PDE1B fine-tunes cellular responses to cyclic nucleotide signaling. Its dual specificity underscores its regulatory role in diverse physiological pathways. PDE1B Protein, Human (sf9, His-GST) is the recombinant human-derived PDE1B protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of PDE1B Protein, Human (sf9, His-GST) is 536 a.a., with molecular weight of ~75 kDa.

HY-P72337

	cGAS Protein, Human (His) 1 Publications Verification cyclic GMP-AMP synthase; cGAMP synthase; h-cGAS; 2'3'-cGAMP synthase; Mab-21 domain-containing protein 1; MB21D1; C6orf150	Human	E. coli
	The cGAS protein is a nucleotidyl transferase that crucially mediates innate immunity by catalyzing the formation of 2',3'-cGAMP from ATP and GTP upon binding to double-stranded DNA (dsDNA). As a DNA sensor, cGAS detects exogenous and endogenous DNA, triggering STING1 activation and type I interferon production. cGAS Protein, Human (His) is the recombinant human-derived cGAS protein, expressed by E. coli , with C-6*His labeled tag. The total length of cGAS Protein, Human (His) is 522 a.a., with molecular weight of ~58.9 kDa.

HY-P7792

	CD157 Protein, Human (HEK293, Fc) ADP-ribosyl cyclase; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST1; cyclic ADP-ribose hydrolase 2; CD157	Human	HEK293
	CD157 Protein, Human (HEK293, Fc) is a recombinant human CD157 expressed in HEK 293 cells with a C-Fc tag at the C-terminus. CD157 Protein is a cell surface receptor and an immunoregulatory molecule.

HY-P703577

	PDE7A1 Protein, Human High affinity 3',5'-cyclic-AMP phosphodiesterase 7A; HCP1; TM22; cAMP-specific phosphodiesterase 7A; PDE7A; Homo sapiens; Human; Hydrolase; 3.1.4.53	Human	E. coli
	PDE7A1 Protein, Human is the recombinant human-derived PDE7A1, expressed by E. coli , with tag Free labeled tag. ,

HY-P72356

	CD38 Protein, Human (Biotinylated, HEK293, His-Avi) ADP-ribosyl cyclase1; 2'-phospho-ADP-ribosyl cyclase; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD38 protein, expressed by HEK293 , with N-Avi, N-6*His labeled tag. The total length of CD38 Protein, Human (Biotinylated, HEK293, His-Avi) is 258 a.a., with molecular weight of 40-50 kDa.

HY-P7791

	CD157 Protein, Human (HEK293, His) rHuCD157, His; ADP-ribosyl cyclase; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST1; cyclic ADP-ribose hydrolase 2; CD157	Human	HEK293
	CD157 Protein, Human (HEK293, His) is a recombinant human CD157 expressed in HEK 293 cells with a His tag at the N-terminus. CD157 Protein is a cell surface receptor and an immunoregulatory molecule.

HY-P7793

	CD157 Protein, Mouse (HEK293, His) rMuCD157, His; ADP-ribosyl cyclase; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST1; cyclic ADP-ribose hydrolase 2; CD157	Mouse	HEK293
	CD157 Protein, Mouse (HEK293, His) is a recombinant mouse CD157 expressed in HEK 293 cells with a His tag at the N-terminus. CD157 Protein is a cell surface receptor and an immunoregulatory molecule.

HY-P70077

	CD38 Protein, Rat (HEK293, His) rRtADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, His ; 17-1A; 323/A3; ACSTD1; CD326; EGP-2; EGP314; EGP40; EpCAM; MOC31; TACST-1; TACSTD1; TROP1;	Rat	HEK293
	CD38 protein plays diverse roles, synthesizing key second messengers: cyclic ADP-ribose (cADPR) for glucose-induced insulin secretion and nicotinate-adenine dinucleotide phosphate (NAADP) as a calcium mobilizer.Its cADPR hydrolase activity adds to its versatility.Notably, CD38 also regulates osteoclastic bone resorption, likely by producing cADPR and initiating a calcium ion signal through ryanodine receptor activation.CD38 Protein, Rat (HEK293, His) is the recombinant rat-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71597

	cGAS Protein, Human (His-SUMO) C6orf150; cGAMP synthase; cGAS; CGAS_HUMAN; cGMP Synthase; Chromosome 6 open reading frame 150; cyclic GMP-AMP synthase; h-cGAS; Hypothetical protein LOC115004; Mab 21 domain containing 1; Mab-21 domain-containing protein 1; MB21D1; MGC131892; MGC142166; MGC142168; OTTHUMP00000016743; OTTHUMP00000039330; protein MB21D1; Uncharacterized protein C6orf150	Human	E. coli
	The cGAS protein is a nucleotidyl transferase that crucially mediates innate immunity by catalyzing the formation of 2',3'-cGAMP from ATP and GTP upon binding to double-stranded DNA (dsDNA). As a DNA sensor, cGAS detects exogenous and endogenous DNA, triggering STING1 activation and type I interferon production. cGAS Protein, Human (His-SUMO) is the recombinant human-derived cGAS protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P703939

	cGAS Protein, Human (362a.a, His) C6orf150; cGAMP synthase; cGAS; CGAS_HUMAN; cGMP Synthase; Chromosome 6 open reading frame 150; cyclic GMP-AMP synthase; h-cGAS; Hypothetical protein LOC115004; Mab 21 domain containing 1; Mab-21 domain-containing protein 1; MB21D1; MGC131892; MGC142166; MGC142168; OTTHUMP00000016743; OTTHUMP00000039330; protein MB21D1; Uncharacterized protein C6orf150	Human	E. coli

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Source
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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80793

	Phospho-ATF2 (Thr71) Antibody ATF2; CREB2; CREBP1; cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding pro	WB, ICC/IF, IP	Human, Mouse
	Phospho-ATF2 (Thr71) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 55 kDa, targeting to Phospho-ATF2 (Thr71). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse.

HY-P80970

	FMRP Antibody CREB1; cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	FMRP Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 71 kDa, targeting to FMRP. It can be used for WB, IF-Cell, IF-Tissue, IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80553

	ATF4 Antibody cyclic AMP-dependent transcription factor ATF-4; CREB-2; cAMP-responsive element-binding protein 2; DNA-binding protein TAXREB67	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	ATF4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 39 kDa, targeting to ATF4. It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80805

	Phospho-CREB (Ser133) Antibody (YA209) CREB1; cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1	WB, IHC-P, IP	Human, Rat
	Phospho-CREB (Ser133) Antibody (YA209) is a non-conjugated and Rabbit origined monoclonal antibody about 35 kDa, targeting to Phospho-CREB (Ser133). It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Rat.

HY-P82439

	ATF5 Antibody (YA2184) ATF5; ATFX; cyclic AMP-dependent transcription factor ATF-5; cAMP-dependent transcription factor ATF-5; Activating transcription factor 5; Transcription factor ATFx	WB, IHC-P, IP	Human, Mouse, Rat
	ATF5 Antibody (YA2184) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2184), targeting ATF5, with a predicted molecular weight of 31 kDa (observed band size: 31 kDa). ATF5 Antibody (YA2184) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

HY-P80552

	ATF2 Antibody Activating transcription factor 2 antibody; Activating transcription factor 2 splice variant ATF2 var2 antibody; ATF 2 antibody; Atf-2 antibody; Atf2 antibody; ATF2 protein antibody; ATF2_HUMAN antibody; cAMP Response Element Binding Protein 2 antibody; cAMP response element binding protein CRE BP1 antibody; cAMP response element-binding protein CRE-BP1 antibody; cAMP responsive element binding protein 2, formerly antibody; cAMP-dependent transcription factor ATF-2 antibody; cAMP-responsive element-binding protein 2 antibody; CRE BP1 antibody; CRE-BP antibody; CREB 2 antibody; CREB-2 antibody; CREB2 antibody; CREBP1 antibody; cyclic AMP dependent transcription factor ATF 2 antibody; cyclic AMP-dependent transcription factor ATF-2 antibody; cyclic AMP-responsive element-binding protein 2 antibody; D130078H02Rik antibody; D18875 antibody; HB 16 antibody; HB16 antibody; Histone acetyltransferase ATF2 antibody; MGC105211 antibody; MGC105222 antibody; MGC111558 antibody; MGC142504 antibody; mXBP antibody; MXBP protein antibody; Tg(Gzma-Klra1)7Wum antibody; TREB 7 antibody; TREB7 antibody	WB	Human, Mouse, Rat
	ATF2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to ATF2. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P81969

	PDE4D Antibody (YA1714) cAMP-specific 3' ; 5' -cyclic phosphodiesterase 4D; DPDE3; PDE43; PDE4D; DPDE3	WB	Human
	PDE4D Antibody (YA1714) is a biotin-conjugated non-conjugated IgG antibody, targeting PDE4D, with a predicted molecular weight of 91 kDa (observed band size: 91 kDa). PDE4D Antibody (YA1714) can be used for WB experiment in human background.

HY-P83667

	Phospho-ATF4 (Ser219) Antibody cyclic AMP-dependent transcription factor ATF-4; CREB-2; cAMP-responsive element-binding protein 2; DNA-binding protein TAXREB67	WB	Human

HY-P83391

	ATF1 Antibody (YA3136) cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1 Protein TREB36; ATF1	WB, ICC/IF, IP	Human
	ATF1 Antibody (YA3136) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3136), targeting ATF1, with a predicted molecular weight of 29 kDa (observed band size: 36 kDa). ATF1 Antibody (YA3136) can be used for WB, ICC/IF, IP experiment in human background.

HY-P82906

	ATF7 Antibody (YA2651) ATF7; ATFA; cyclic AMP-dependent transcription factor ATF-7; cAMP-dependent transcription factor ATF-7; Activating transcription factor 7; Transcription factor ATF-A	WB	Human, Mouse, Rat
	ATF7 Antibody (YA2651) is a biotin-conjugated non-conjugated IgG antibody, targeting ATF7, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). ATF7 Antibody (YA2651) can be used for WB experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-130530

AP-C5		Alkynes
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 7.2, which can be used for the research of diarrheal disease . AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133190

Bis-propargyl-PEG7		PROTAC Synthesis Alkynes
Bis-propargyl-PEG7 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG7 can be used to synthesize the polymer linked multimers of guanosine-3', 5'-cyclic monophosphates . Bis-propargyl-PEG7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-117186

Bis-propargyl-PEG6		Alkynes PROTAC Synthesis
Bis-propargyl-PEG6 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG6 can be used to synthesize the polymer linked multimers of guanosine-3', 5'-cyclic monophosphates . Bis-propargyl-PEG6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147150

8-Azido-cADPR		Azide
8-Azido-cADPR, with its photoactive azido group, is a potent photoaffinity probe. 8-Azido-cADPR can be used for the identification and characterization of cADPR-binding proteins . 8-Azido-cADPR is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-21545

5'-O-DMT-Bz-rA		Nucleoside Phosphoramidites
5'-O-DMT-Bz-rA is an intermediate for cyclic di-nucleotide compounds synthesis .

HY-45491

Dmt-2'-f-dc(ac) amidite 2'-F-Ac-dC Phosphoramidite; DMT-2′Fluoro-dC(ac) Phosphoramidite		Nucleoside Phosphoramidites
Dmt-2'-f-dc(ac) amidite (2'-F-Ac-dC Phosphoramidite) is a phosphoramidite which can be used in the preparation of cyclic purine dinucleotides .

HY-157693

*C18:1 Cyclic* LPA**		Phospholipids
C18:1 Cyclic LPA is a naturally occurring analog of the growth factor-like phospholipid mediator, lysophosphatidic acid (LPA), characterized by the formation of a 5-membered ring between its sn-2 hydroxy group and the sn-3 phosphate. This unique structure allows C18:1 Cyclic LPA to influence a variety of cellular functions, such as inhibiting cell cycle progression, promoting the formation of stress fibers, curtailing tumor cell invasiveness and metastasis, and modulating the differentiation and survival of neuronal cells. Notably, many of these cellular effects elicited by C18:1 Cyclic LPA appear to counter those induced by LPA, despite the activation of seemingly similar receptor populations.

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