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Results for "

TLR inhibitor,TLR3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Toll-like Receptor (TLR) (365) ADC Cytotoxin (1) AIM2 (2) Akt (2) AMPK (1) Amyloid-β (1) Androgen Receptor (2) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (9) Apoptosis (13) ATM/ATR (1) Autophagy (31) Bacterial (5) Bcl-2 Family (2) Beta-lactamase (1) BMX Kinase (1) Btk (1) Caspase (1) Complement System (1) COX (2) Deubiquitinase (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (5) Dynamin (2) EBV (2) EGFR (1) Endogenous Metabolite (4) ERK (2) HBV (3) HCV (5) Histone Acetyltransferase (2) HIV (12) HSP (3) HSV (9) IFNAR (4) IKK (1) Influenza Virus (3) Interleukin Related (17) IRAK (3) Isotope-Labeled Compounds (7) JAK (3) Keap1-Nrf2 (1) Liposome (1) MAPKAPK2 (MK2) (1) Mitochondrial Metabolism (2) MMP (3) MyD88 (9) NF-κB (22) NO Synthase (2) NOD-like Receptor (NLR) (3) Nucleoside Antimetabolite/Analog (42) p38 MAPK (6) Parasite (21) PD-1/PD-L1 (2) Phosphatase (1) PI3K (2) PKD (1) Potassium Channel (2) PPAR (1) PROTAC Linkers (4) Pyroptosis (2) RANKL/RANK (4) Reactive Oxygen Species (7) SARS-CoV (25) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (26) STAT (3) Stearoyl-CoA Desaturase (SCD) (2) STING (1) TNF Receptor (18) Wnt (4) β-catenin (4)
By Research Areas:	Cancer (155) Cardiovascular Disease (13) Infection (77) Inflammation/Immunology (313) Metabolic Disease (13) Neurological Disease (12)
Click Chemistry:	Azide (2) Alkynes (4)
Oligonucleotides:	Nucleosides and their Analogs (29) Nucleoside Phosphoramidites (4) CpG ODNs (70) Pre-designed siRNA Sets (26) Adjuvant (15) Phospholipids (1) Antisense Oligonucleotides (6) siRNAs (26)

469

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

151

Oligonucleotides

Targets Recommended: Toll-like Receptor (TLR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148045

TLR9-IN-1	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR9-IN-1 is a potent and selective *TLR9* inhibitor with an IC₅₀ value of 7 nM for human TLR9. TLR9-IN-1 can be used for researching diseases associated with undesirable immune response .

HY-139323

TLR7/8-IN-1 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8-IN-1 is a crystalline from of a *TLR7/TLR8* inhibitor extracted from patent WO2019220390, compound 2b. TLR7/8-IN-1 can be used for the research of autoimmune disease .

HY-103698

TLR7/8 agonist 1	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8 agonist 1 is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline.

HY-103698A

TLR7/8 agonist 1 dihydrochloride	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8 agonist 1 dihydrochloride is a toll-like receptor *TLR7/TLR8* dual-agonistic imidazoquinoline .

HY-139017

TLR7/8 agonist 4	Toll-like Receptor (TLR)	Cancer
TLR7/8 agonist 4 (compound 41) is a potent *TLR7/8* agonist. TLR7/8 agonist 4 has anti-cancer activity .

HY-147236

TLR7/8 agonist 7	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8 agonist 7 (compound 10) is a TLR7/8 agonist. TLR7/8 agonist 7 activates a variety of immune cells and it can be used to synthesize immune stimulating antibody conjugate (ISAC) molecules. TLR7/8 agonist 7 can be used for the research of immunity .

HY-145886

TLR7/8 antagonist 1	Toll-like Receptor (TLR)	Infection Inflammation/Immunology Cancer
TLR7/8 Antagonist 1 (Compound 16c) is the potent antagonist of *TLR7/8* with IC₅₀s of 3.91 and 2.19 μM, respectively. TLR7/8 Antagonist 1 is an imidazoquinoline derivative compound. Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for researching infectious disease, cancer, and autoimmune disorders .

HY-145885

TLR7/8 agonist 6	Toll-like Receptor (TLR)	Infection Inflammation/Immunology Cancer
TLR7/8 agonist 6 (Compound 4) is the potent agonist of *TLR7/8* with IC₅₀s of 0.18 and 5.34 μM, respectively. TLR7/8 agonist 6 is an imidazoquinoline derivative compound. Toll-like receptors (TLRs) 7 and 8 are key targets in the development of immunomodulatory drugs for researching infectious disease, cancer, and autoimmune disorders .

HY-163398

TLR7-IN-1	Toll-like Receptor (TLR)	Cancer
TLR7-IN-1 (compound 16-A) is a *TLR7* inhibitor with an EC₅₀ value of 0.001 µM .

HY-163829

TLR2 agonist 1	Toll-like Receptor (TLR) NF-κB	Cancer
TLR2 agonist 1 (Compound R-7d) is an agonist for human toll-like receptor 2 (TLR 2) with an EC₅₀ of 116 pM. TLR2 agonist 1 enhances NF-κB promoter activation through TLR2/TLR1 heterodimers .

HY-141454

TLR8 agonist 2	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR8 agonist 2 is a potent and selective *TLR8* agonist with an EC₅₀ of 3 nM for human TLR8. TLR8 agonist 2 shows less active against human TLR7 (EC₅₀ of 33.33 μM) .

HY-141454A

TLR8 agonist 2 hydrochloride	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR8 agonist 2 hydrochloride is a potent and selective *TLR8* agonist with an EC₅₀ of 3 nM for human TLR8. TLR8 agonist 2 hydrochloride shows less active against human TLR7 (EC₅₀ of 33.33 μM) .

HY-107575

TLR4-IN-C34 5+ Cited Publications	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4-IN-C34 is an orally active *TLR4* inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis .

HY-W011400

TLR1 3 Publications Verification	MyD88	Inflammation/Immunology
TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses .

HY-144619

TLR7/8 antagonist 2	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8 antagonist 2 (Compound 15) is a potent and orally active agonist of *TLR7/8* with IC₅₀s of 4.9 and 0.6 nM, respectively. Inappropriate activation of TLR7 and TLR8 is linked to several autoimmune diseases, such as lupus erythematosus. TLR7/8 antagonist 2 has the potential for the research of autoimmune diseases .

HY-163998

TLR4-IN-1	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4-IN-1 (compound 3k) inhibits the cell viability of RAW264.7 with an IC₅₀ of 1.02 μM. TLR4-IN-1 inhibits the release of cytokine TNF-α, IL-1β and IL-6, and exhibits anti-inflammatory efficacy in rats rheumatoid arthritis models .

HY-131952

TLR7/8/9-IN-1 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8/9-IN-1 is a potent and orally bioavailable small molecule antagonist (IC₅₀ = 43 nM) of Toll-like receptors 7/8/9 (TLR7/8/9).

HY-139017A

TLR7/8 agonist 4 TFA	Toll-like Receptor (TLR)	Cancer
TLR7/8 agonist 4 TFA (compound 41) is a potent *TLR7/8* agonist. TLR7/8 agonist 4 has anti-cancer activity .

HY-162579

TLR7 agonist 22	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 22 (Compound 11a) emerges as a selective TLR7 agonist with an IC₅₀ value of 25.86 μM. TLR7 agonist 22 inhibits the cellular HBsAg secretion and effectively activates TLR7, thereby inducing the secretion of **TLR7-regulated *cytokines IL-12, TNF-αand IFN-αin human PBMC cells. TLR7 agonist 22 is a promising for research in the field of developing novel immunomodulatory anti-HBV agents .***

HY-130797

TLR7/8 agonist 3	Toll-like Receptor (TLR)	Cancer
TLR7/8 agonist 3 is a potent *TLR7* and *TLR8* agonist, extracted from patent WO2016057618 (compound of formula (II)) .

HY-153544

TLR7/8 agonist 9	Toll-like Receptor (TLR)	Cancer
TLR7/8 agonist 9 (Compound 25a) is a *TLR7/8* agonist, with EC₅₀s of 40 nM and 23 nM for hTLR7/8. TLR7/8 agonist 9 has anti-tumor activity and improves the antitumor activity of PD-1/PD-L1 blockade. TLR7/8 agonist 9 can be used for research of cancer immunotherapy .

HY-142963

TLR4/NF-κB/MAPK-IN-1	NF-κB p38 MAPK Toll-like Receptor (TLR)	Neurological Disease Inflammation/Immunology
TLR4/NF-κB/MAPK-IN-1 is a new type of antineuroinflammatory agent by suppressing TLR4/NF-kB/MAPK pathways.

HY-W092043

TLR4-IN-C34-C2-COOH 1 Publications Verification	PROTAC Linkers Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis .

HY-163670

TLR7 agonist 21	Toll-like Receptor (TLR)	Infection
TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7(TLR7), with an EC₅₀ of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7). TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, IFN-α1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections .

HY-148338

TLR8 agonist 5	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR8 agonist 5 is a potent *TLR8* agonist with an EC₅₀ value of 20 nM for HEK-Blue hTLR8. TLR8 agonist 5 activates the immune response .

HY-111358

TLR7 agonist 1	Toll-like Receptor (TLR)	Infection
TLR7 agonist 1 is a potent, selective and oral *TLR7* agonist with an IC₅₀ of 90 nM.

HY-153543

TLR7/8 agonist 8	Toll-like Receptor (TLR)	Cancer
TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC₅₀s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade .

HY-168157

TLR7 agonist 26	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 26 (Compound 4) is a potent Toll-like receptor 7 (TLR7) agonist, with an EC₅₀ of 225.5 nM. TLR7 agonist 26 shows immunopotentiating effects .

HY-162115

TLR7 agonist 17	Toll-like Receptor (TLR)	Cancer
TLR7 agonist 17 (compound 20) is a potent *TLR7* agonist with EC₅₀ values of 12 nM and 17 nM for hTLR7 and mTLR7, respectively. TLR7 agonist 17 shows anticancer activity .

HY-145961

TLR7 agonist 4	Toll-like Receptor (TLR)	Cancer
TLR7 agonist 4 (Compound 1.2) is a *TLR7* agonist with an EC₅₀ of 4.3 nM .

HY-156175

TLR7 agonist 14	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 14 (compound 17b) is a highly potent *TLR7* agonist with an EC₅₀ of 18 nM. TLR7 agonist 14 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations .

HY-156176

TLR7 agonist 15	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 15 (compound 16b) is a highly potent *TLR7* agonist with an EC₅₀ of 18 nM. TLR7 agonist 15 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations .

HY-156177

TLR7 agonist 16	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 16 (compound 16d) is a highly potent *TLR7* agonist with an EC₅₀ of 18 nM. TLR7 agonist 16 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations .

HY-152726

TLR7 agonist 9	Toll-like Receptor (TLR) Nucleoside Antimetabolite/Analog	Infection Cancer
TLR7 agonist 9 (compound 10) is an aonist of *TLR7. TLR7 agonist 9 can be used for research of cancer and infectious disease . TLR*7 agonist 9 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-153070

TLR7 agonist 5	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 5 (compound IIb-11) is an *TLR7* agonist with an EC₅₀ value of ~4 nM .

HY-153072

TLR7 agonist 7	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 7 (compound IIb-26) is an *TLR7* agonist with an EC₅₀ value of ~4 nM .

HY-153073

TLR7 agonist 8	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 8 (compound IIb-34) is an *TLR7* agonist with an EC₅₀ value of ~4 nM .

HY-117602

TLR7 agonist 3 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 3 (Compound 2) is a potent agonist of toll-like receptor 7 (TLR7). TLR7 has an important role in immune activation processes and represents an emerging agent discovery target for the development of immunomodulators .

HY-161726

TLR7 agonist 23	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 23 (compound 12b) is a potent Toll Like Receptor-7 (TLR7) agonist with a EC₅₀ of 0.15 uM. TLR7 agonist 23 can be used in the study of immunological diseases .

HY-162845

TLR7/8 agonist 11	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8 agonist 11 (compound 30) is a potent agonist of hTLR7 and hTLR8, with EC₅₀s of 31.1 nM and 13.1 nM, respectively. TLR7/8 agonist 11 plays an important role in adaptive and innate immune responses .

HY-153071

TLR7 agonist 6	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 6 (compound IIb-19) is an *TLR7* agonist with an EC₅₀ value of 1.0 nM .

HY-108473

CU-CPT 4a 1 Publications Verification TLR3-IN-1	Toll-like Receptor (TLR)	Cancer
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β .

HY-153900

TLR8 agonist 6	Toll-like Receptor (TLR)	Cancer
TLR8 agonist 6 (Compound A) is a *TLR8* agonist, with an EC₅₀ of 0.052 μM. TLR8 agonist 6 induces IL-12p40 production in human PBMC (EC₅₀: 0.031 μM). TLR8 agonist 6 can be used in the research of virus resistance, infection resistance, autoimmunity, tumor, etc .

HY-168159

TLR7 agonist 27	Toll-like Receptor (TLR) NOD-like Receptor (NLR)	Inflammation/Immunology
TLR7 agonist 27 (compound 24) is a potent *TLR7* agonist with an EC₅₀ of 238.1 nM. TLR7 agonist 27 shows weak agonistic activity against NOD2 (nucleotide-binding oligomerization domain 2) (EC₅₀ of 6.2 μM). TLR7 agonist 27 is a potent immunostimulant, and can be used as a vaccine adjuvant and/or immunotherapeutic .

HY-149650

TLR4 agonist-1	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4 agonist-1 (compound 17a) is a potent agonist of Toll-like Receptor 4 (TLR4), and induces the generation of MIP-1β in RAW 264.7 and MM6 cells .

HY-103039

TLR7 agonist 2 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 2 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM.

HY-153460

TLR7/8/9 antagonist 2	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8/9 antagonist 2 is an orally active *TLR7/8/9* antagonist. TLR7/8/9 antagonist 2 has inhibitory activities for HEK/hTLR7, HEK/hTLR8 and HEK/hTLR9 with IC₅₀ values of 0.011 μM, 0.029 μM and 0,052 μM, respectively.TLR7/8/9 antagonist 2 has high bioavailability in vivo.TLR7/8/9 antagonist 2 can be used for the research of auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis .

HY-162163

TLR7 agonist 19	Toll-like Receptor (TLR)	Cancer
TLR7 agonist 19 (Compound 14) is a Toll-like receptor 7 (TLR7) agonist with excellent pharmacokinetic properties and synergistic antitumor activity.

HY-158694A

TLR7 agonist 20 hydrochloride	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 20 hydrochloride is an imidazoquinoline analogue. TLR7 agonist 20 hydrochloride is a potent *TLR7* specific agonist, with an EC₅₀ value of 0.23 μM for hTLR7. TLR7 agonist 20 hydrochloride shows strong adjuvant activity on spike antibody levels which induces a strong T helper 1 (Th1) response with increase in IgG2b and IgG2c, in addition to IgG1 .

HY-156691A

TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride	Drug-Linker Conjugates for ADC	Cancer
TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride is a Drug-Linker Conjugates for ADC. TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride is the hydrochloride form of TLR7/8 agonist 4 hydroxy-PEG6-acid. TLR7/8 agonist 4 hydroxy-PEG6-acid consists of TLR7/8 agonist 4 (HY-139017) and a linker Hydroxy-PEG6-acid (HY-133050), and can be used for synthesis of ADCs .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1346

Robinin 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Plants Vigna unguiculata Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR) Apoptosis
Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect ^[3] .

HY-N9347

Stepharine 1 Publications Verification	Cardiovascular Disease Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Toll-like Receptor (TLR)
Stepharine, an natural alkaloid, directly interactes with *TLR4* and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects .

HY-N0795

Procyanidin B1 3 Publications Verification	Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR)
Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to *TLR4/MD-2* complex, and has anti-inflammatory activity.

HY-N6673

Okanin 1 Publications Verification	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Cercis chinensis Bunge Source classification Plants Compositae Chalcones Flavonoids Phenols Polyphenols Disease Research Fields	Toll-like Receptor (TLR) NF-κB
Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the *TLR4/NF-κB* signaling pathways .

HY-P2358

PSMα3	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR)
PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA) .

HY-N0201

Atractylenolide I 2 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Astragalus caprinus L. Plants Compositae Disease Research Fields Cancer	TNF Receptor Toll-like Receptor (TLR) JAK STAT
Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and *STAT3* in A375 cells, and acts as a *TLR4*-antagonizing agent.

HY-N1346R

Robinin (Standard)	Structural Classification Flavonoids Flavones Leguminosae Plants Vigna unguiculata	Toll-like Receptor (TLR) Apoptosis
Robinin (Standard) is the analytical standard of Robinin. This product is intended for research and analytical applications. Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect ^[3] .

HY-N10119

Ganoderterpene A	Triterpenes Terpenoids Source classification Polyporaceae Plants	p38 MAPK
Ganoderterpene A attenuates LPS-induced inflammation and apoptosis via suppressing MAPK and TLR-4/NF-κB pathways in BV-2 cells.

HY-N12527

Hyperelamine A	Structural Classification Hypericum elatoides R. Keller Source classification Phenols Polyphenols Hypericaceae Plants	NF-κB
Hyperelamine A (compound 5) is a polycyclic polyprenylated acylphloroglucinols (PPAPs). Hyperelamine A exhibits inhibitory activity against LPS-activated NO production in BV-2 cells via TLR-4/NF κB signaling .

HY-N0795R

Procyanidin B1 (Standard)	Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants Biflavones	Toll-like Receptor (TLR)
Procyanidin B1 (Standard) is the analytical standard of Procyanidin B1. This product is intended for research and analytical applications. Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits, binds to TLR4/MD-2 complex, and has anti-inflammatory activity.

HY-N0392

Polygalasaponin F	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Polygalaceae Polygala japonica Houtt. Plants Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR) PI3K Akt NF-κB
Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secretion through the regulation of the *TLR4-PI3K/AKT-NF-kB* signaling pathway .

HY-N0774

Isofraxidin 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Inflammation/Immunology Disease Research Fields Araliaceae	ERK COX MMP Toll-like Receptor (TLR)
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits *TLR4*/myeloid differentiation protein-2 (MD-2) complex formation .

HY-N0201R

Atractylenolide I (Standard)	Structural Classification Terpenoids Sesquiterpenes Source classification Astragalus caprinus L. Plants Compositae	TNF Receptor Toll-like Receptor (TLR) JAK STAT
Atractylenolide I (Standard) is the analytical standard of Atractylenolide I. This product is intended for research and analytical applications. Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.

HY-N7697C

Chitohexaose hexahydrochloride	Classification of Application Fields Animals Source classification Disease Research Fields Inflammation/Immunology Saccharides	Toll-like Receptor (TLR)
Chitohexaose hexahydrochloride is a chitosan oligosaccharide with anti-inflammatory effect. Chitohexaose hexahydrochloride binds to the active sites of *TLR4* and inhibits LPS induced inflammation .

HY-N0392R

Polygalasaponin F (Standard)	Triterpenes Structural Classification Terpenoids Source classification Polygalaceae Polygala japonica Houtt. Plants	Toll-like Receptor (TLR) PI3K Akt NF-κB
Polygalasaponin F (Standard) is the analytical standard of Polygalasaponin F. This product is intended for research and analytical applications. Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secretion through the regulation of the TLR4-PI3K/AKT-NF-kB signaling pathway .

HY-N0774R

Isofraxidin (Standard)	Structural Classification Monophenols Source classification Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	ERK COX MMP Toll-like Receptor (TLR)
Isofraxidin (Standard) is the analytical standard of Isofraxidin. This product is intended for research and analytical applications. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation .

HY-N2345

Procyanidin B3	Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Disease Research Fields Cancer	Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor
Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the *TLR4/MD-2* complex. Procyanidin B3 can be used in research on prostate cancer and arthritis ^[3] .

HY-N0703

Schaftoside 4 Publications Verification	Structural Classification Flavonoids Eleusine indica (Linn.) Gaertn. Classification of Application Fields Flavones Leguminosae Gramineae Source classification Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR) MyD88 Dynamin Mitochondrial Metabolism Autophagy
Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission .

HY-N11768

4-Methoxylonchocarpin	Structural Classification Monophenols Source classification Phenols Plants Moraceae Dorstenia mannii Hook.f.	NF-κB Interleukin Related Toll-like Receptor (TLR)
4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) *TLR4* to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model .

HY-113134

25-Hydroxycholesterol 15+ Cited Publications 25-OHC	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite
25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells.

HY-N1934

Dihydroberberine	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Potassium Channel HSP
Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy .

HY-N2345R

Procyanidin B3 (Standard)	Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants Biflavones	Histone Acetyltransferase Toll-like Receptor (TLR) Androgen Receptor
Procyanidin B3 (Standard) is the analytical standard of Procyanidin B3. This product is intended for research and analytical applications. Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase (HAT). By inhibiting p300 HAT-mediated acetylation of the androgen receptor (androgen receptor). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis ^[3] .

HY-N8277

Kdo2-Lipid A ammonium 2 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Toll-like Receptor (TLR) TNF Receptor
Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for *TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF* and PGE2 .

HY-N0703R

Schaftoside (Standard)	Structural Classification Flavonoids Eleusine indica (Linn.) Gaertn. Flavones Leguminosae Gramineae Source classification Plants Glycyrrhiza uralensis Fisch.	Toll-like Receptor (TLR) MyD88 Dynamin Mitochondrial Metabolism Autophagy
Schaftoside (Standard) is the analytical standard of Schaftoside. This product is intended for research and analytical applications. Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission .

HY-D1056

Lipopolysaccharides, from E. coli O55:B5 Maximum Cited Publications 213 Publications Verification LPS	Structural Classification Polysaccharides Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Saccharides	Toll-like Receptor (TLR)
Lipopolysaccharides, from E. coli O55:B5 is an endotoxin extracted from E. coli O55:B5, consisting of an antigen-specific chain, A core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activates *TLR-4* of immune cells. Lipopolysaccharides, from E. coli O55:B5 can induce the change of body temperature in rats with dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 caused a heterogeneous and dose-independent increase in body temperature in rats ^[3] .

HY-N1934R

Dihydroberberine (Standard)	Alkaloids Structural Classification other families Source classification Plants Isoquinoline Alkaloids	Potassium Channel HSP
Dihydroberberine (Standard) is the analytical standard of Dihydroberberine. This product is intended for research and analytical applications. Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy .

HY-N0625A

Alpinetin 4 Publications Verification	Structural Classification Alpinia katsumadai Hayata Classification of Application Fields Source classification Plants Monophenols Flavonoids Flavonones Phenols Inflammation/Immunology Disease Research Fields Zingiberaceae Cancer	PPAR Keap1-Nrf2 Toll-like Receptor (TLR)
Alpinetin is a flavonoid isolated from cardamom and possesses antitumor, antiinflammation, hepatoprotective, cardiovascular protective, lung protective, antibacterial, antiviral, neuroprotective properties. Alpinetin inhibits lipopolysaccharide (LPS)-induced inflammation, activates PPAR-γ, activates Nrf2, and inhibits TLR4 expression to protect LPS-induced renal injury ^[3] .

HY-N2095

Atractylone Atractylon	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Inflammation/Immunology Disease Research Fields Erythrina sigmoidea Hua	Influenza Virus
Atractylone (Atractylon) is a sesquiterpenoid extracted from Atractylodis Rhizoma. Atractylone (Atractylon) alleviates influenza A virus (IAV)-induced lung injury via regulating the TLR7 signaling pathway, and acts as a promising agent for IAV treatment. Atractylone (Atractylon) inhibits the degranulation of mast cell and exhibits potential for the treatment of mast cell-mediated allergic reactions .

HY-N8413

Chlojaponilactone B	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Chloranthus japonicus Sieb. Plants	Toll-like Receptor (TLR) Reactive Oxygen Species NF-κB
Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting *TLR4* and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α .

HY-N0405

Orientin 3 Publications Verification	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	TNF Receptor Interleukin Related
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits *TLR4* and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N9541

Chaetoglobosin Vb	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	Others
Chaetoglobosin Vb is a novel cytotoxic alkaloid with anti-inflammatory and antioxidant activities. Chaetoglobosin Vb can inhibit oxidative stress induced by LPS stimulation, reduce the production of reactive oxygen species and increase the expression of the antioxidant enzyme superoxide dismutase (SOD). Chaetoglobosin Vb significantly reduced the gene and protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) induced by LPS, and alleviated the production of proinflammatory cytokines such as TNF-α, IL-6 and IL-1β. Chaetoglobosin Vb exerts its biological activity through the TLR4-mediated MyD88-dependent signaling pathway and the TRIF-dependent signaling pathway, which is specifically manifested by inhibiting the phosphorylation of p38, ERK, and JNK MAPK and the translocation of NF-κB p65 subunit to the nucleus. Chaetoglobosin Vb showed no cytotoxic effect in the concentration range of 25-100 μM and promoted SOD enzyme activity and phosphorylation of p38, ERK1/2 and JNK in a dose-dependent manner .

HY-N6612

D-Glucuronic acid 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Toll-like Receptor (TLR)
D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity ^[3] .

HY-N0405R

Orientin (Standard)	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	TNF Receptor Interleukin Related
Orientin (Standard) is the analytical standard of Orientin. This product is intended for research and analytical applications. Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N12110

SMU-CX1	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants	Toll-like Receptor (TLR) SARS-CoV
SMU-CX1 is a specific TLR3 inhibitor (IC₅₀: 0.11 μM) with IC₅₀ ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC₅₀ of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5 .

HY-N6612R

D-Glucuronic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite Toll-like Receptor (TLR)
D-Glucuronic acid (Standard) is the analytical standard of D-Glucuronic acid. This product is intended for research and analytical applications. D-Glucuronic acid is a major component of many anti-inflammatory proteoglycans, which can promote embryonic development and inhibit cell aggregation. After being metabolized into ethyl glucuronide (HY-113093), D-Glucuronic acid activates Toll-like receptor 4 (TLR4), causing pain. D-Glucuronic acid and its derivative glucurono-lactone can serve as liver detoxifiers for human health prevention, and its derivatives also possess anti-tumor activity ^[3] .

HY-N2055

Kaempferol 3-O-sophoroside	Panax ginseng C. A. Meyer Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Phenols Polyphenols Inflammation/Immunology Disease Research Fields Araliaceae	Toll-like Receptor (TLR) NF-κB TNF Receptor AMPK
Kaempferol 3-O-sophoroside is an orally active derivative of Kaempferol. It exhibits anti-inflammatory, analgesic, and antidepressant effects. Kaempferol 3-O-sophoroside is an inhibitor of the cell surface receptor toll-like receptor *(TLR) 2/4* for High mobility group box 1 (HMGB1), and it also exerts anti-inflammatory effects by blocking the activation of NF-κB expression and the production of TNF-α. Kaempferol 3-O-sophoroside promotes the production of brain-derived neurotrophic factor (BDNF) and enhances autophagy by binding to AMP-activated protein kinase (AMPK), thereby exerting antidepressant effects. Kaempferol 3-O-sophoroside holds promise for research in the fields of inflammation and neurodegenerative diseases ^[3] .

Cat. No.	Product Name	Chemical Structure

HY-13740S

Resiquimod-d5
Resiquimod-d₅ is deuterium labeled Resiquimod. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α[1][2].

HY-17589AS

Chloroquine-d5 1 Publications Verification
Chloroquine-d₅ is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-W031727S

Hydroxychloroquine-d4-1 sulfate
Hydroxychloroquine-d₄-1 (sulfate) is the deuterium labeled Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

HY-W031727S1

Hydroxychloroquine-d5
Hydroxychloroquine-d₅ is the deuterium labeled Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].

HY-B1370S

Hydroxychloroquine-d4 sulfate
Hydroxychloroquine-d₄ (sulfate) is the deuterium labeled Hydroxychloroquine sulfate. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

HY-135811S

Desethyl chloroquine-d4
Desethyl chloroquine-d₄ is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

HY-135811S1

Desethyl chloroquine-d5
Desethyl chloroquine-d₅ is deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].

HY-B0180S

Imiquimod-d6
Imiquimod-d₆ is the deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].

HY-B0180S1

Imiquimod-d9
Imiquimod-d₉ is deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].

HY-17589S1

Chloroquine-d4 phosphate

Chloroquine-d₄ (phosphate) is the deuterium labeled Chloroquine phosphate. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-113134S

25-Hydroxycholesterol-d6
25-Hydroxycholesterol-d₆ (25-OHC-d₆) is the deuterium labeled 25-Hydroxycholesterol. 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells[1][2].

HY-17589S

Chloroquine-d5 diphosphate

Chloroquine-d₅ (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

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