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Isoforms Recommended:	COX-2

Results for "

COX-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (490) 5-HT Receptor (2) Acyltransferase (2) Adrenergic Receptor (1) Akt (5) Aldose Reductase (1) Amyloid-β (2) Antibiotic (7) Apoptosis (84) Autophagy (45) Bacterial (25) Bcl-2 Family (5) Beta-secretase (2) Biochemical Assay Reagents (1) c-Fms (1) Calcium Channel (1) CaMK (1) Carbonic Anhydrase (5) Caspase (9) Cathepsin (1) Chloride Channel (2) Cholinesterase (ChE) (7) CMV (2) Cytochrome P450 (2) Dengue virus (1) Dopamine Receptor (2) Drug Metabolite (8) EGFR (1) Endogenous Metabolite (46) Enterovirus (2) Epoxide Hydrolase (2) ERK (8) FAAH (4) Ferroptosis (7) Flavivirus (1) Fluorescent Dye (1) Fungal (4) GABA Receptor (2) Glucocorticoid Receptor (1) Glucosidase (1) GLUT (2) Glutathione Peroxidase (2) HDAC (1) Histone Acetyltransferase (7) HIV (1) HSV (2) IGF-1R (2) IKK (5) Influenza Virus (9) Interleukin Related (14) Isotope-Labeled Compounds (37) JNK (2) Leukotriene Receptor (5) Lipoxygenase (29) LOX-1 (1) Macrophage migration inhibitory factor (MIF) (2) MAP3K (1) MEK (1) Melatonin Receptor (4) Microtubule/Tubulin (3) Mitophagy (16) MMP (7) Monoamine Oxidase (1) MyD88 (1) NF-κB (69) NO Synthase (40) NOD-like Receptor (NLR) (1) Notch (2) Opioid Receptor (3) p38 MAPK (17) Parasite (9) PGE synthase (15) Phosphatase (1) Phosphodiesterase (PDE) (1) Phospholipase (3) PI3K (4) PKA (1) PKC (1) Potassium Channel (1) PPAR (10) Progesterone Receptor (3) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (7) PTEN (2) RAR/RXR (1) Reactive Oxygen Species (24) Ribosomal S6 Kinase (RSK) (2) Sirtuin (1) Sodium Channel (1) Src (1) STAT (2) Survivin (1) TGF-β Receptor (1) TNF Receptor (17) Toll-like Receptor (TLR) (4) Topoisomerase (2) Transthyretin (TTR) (2) TRP Channel (3) VEGFR (2) Virus Protease (6) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (225) Cardiovascular Disease (26) Endocrinology (7) Infection (30) Inflammation/Immunology (480) Metabolic Disease (36) Neurological Disease (40)
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Oligonucleotides:	Antioxidants (1) Preservatives (1) Chelating Agents (1)

583

Inhibitors & Agonists

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174

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Targets Recommended: COX

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14445

FK 3311 COX-2 Inhibitor V	COX	Inflammation/Immunology
FK 3311 (COX-2 Inhibitor V) is a selective inhibitor of *COX-2* with antiinflammatory agent.

HY-147794

COX-2-IN-18	COX	Cancer
COX-2-IN-18 (Compound 3) is a potent inhibitor of *COX-2. COX-2-IN-18 possesses good COX-2* inhibitory activity (IC₅₀ = 0.775 μM) compared to the reference agent, Celecoxib (IC₅₀ = 0.153 μM). COX-2-IN-18 has the potential for the research of cancer diseases .

HY-115934

COX-2-IN-7	COX	Inflammation/Immunology
COX-2-IN-7 (compound 4a) is a potent, selective, and orally active inhibitor of *COX-2* with an IC₅₀ of 6.585 uM. COX-2-IN-7 has higher COX-2 selectivity than Celecoxib. COX-2-IN-7 shows good in vivo anti-inflammatory and low ulcerogenic activity .

HY-115935

COX-2-IN-8	COX	Inflammation/Immunology
COX-2-IN-8 (compound 6a) is a potent, selective, and orally active inhibitor of *COX-2* with an IC₅₀ of 6.585 uM. COX-2-IN-8 has higher COX-2 selectivity than Celecoxib. COX-2-IN-8 shows good in vivo anti-inflammatory and low ulcerogenic activity .

HY-115936

COX-2-IN-9	COX	Inflammation/Immunology
COX-2-IN-9 (compound 7a) is a potent, selective, and orally active inhibitor of *COX-2* with an IC₅₀ of 10.17 uM. COX-2-IN-9 has higher COX-2 selectivity than Celecoxib. COX-2-IN-9 shows good in vivo anti-inflammatory and low ulcerogenic activity .

HY-168070

COX-2-IN-48	COX NF-κB NO Synthase	Inflammation/Immunology
COX-2-IN-48 (5-25), a *COX-2* inhibitor with an IC₅₀ of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, the phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS .

HY-162244

COX-2-IN-40	COX	Inflammation/Immunology
COX-2-IN-40 (compound 17) is a *COX-2* inhibitor with the IC₅₀ of 14.86 μM. COX-2-IN-40 can be used for study of chronic pain .

HY-147961

COX-2-IN-23	COX	Inflammation/Immunology
COX-2-IN-23 (compound 9a) is a selective *COX-2* inhibitor with IC₅₀ values of 0.28 and 20.14 μM for COX-2 and COX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity.

HY-161147

COX-2-IN-37	COX	Inflammation/Immunology
COX-2-IN-37 (compound 11) is a potent and selective *COX-2* inhibitor. COX-2-IN-37 has strong antioxidant activity with an IC₅₀ of 33.0 μg/mL .

HY-157578

COX-2-IN-38	COX	Inflammation/Immunology
COX-2-IN-38 (compound 52) is a potent inhibitor of COX*-2, with the IC₅₀ value of 79.4 nM .

HY-157583

COX-2-IN-39	COX	Others
COX-2-IN-39 (compound 44) is a potent inhibitor of *COX*-2, with the IC₅₀ value of 0.4 nM .

HY-156254

COX-2-IN-35	COX	Inflammation/Immunology
COX-2-IN-35 (compound 7) is a selective *COX-2* inhibitor with an IC₅₀ of 4.37 nM. COX-2-IN-35 has anti-inflammatory activity .

HY-145988

COX-2-IN-11	COX	Inflammation/Immunology
COX-2-IN-11 (compound 7b2) is a potent and selective inhibitor of *COX-2. COX-2*-IN-11 has the potential for the research of inflammation diseases .

HY-161994

COX-2-IN-47	COX	Inflammation/Immunology
COX-2-IN-47 (compound 6c ) is a selective *COX-2* inhibitor with IC₅₀ value of 0.03 μM. COX-2-IN-47 has antiedema activity .

HY-159562

COX-2-IN-46	COX	Inflammation/Immunology
COX-2-IN-46 (compound 5m) is an anti-inflammatory agent with potent analgesic activity. COX-2-IN-46 exhibits a significant inhibitory effect on *COX-2* (IC₅₀=87.74 nM) .

HY-146371

COX-2-IN-13	COX	Inflammation/Immunology
COX-2-IN-13 (compound 13e) is a potent and selective inhibitor of *COX-2* with an IC₅₀ of 0.98 μM. COX-2-IN-13 is an anti-inflammatory agent. COX-2-IN-13 shows safety in-vivo acute toxicity study .

HY-146370

COX-2-IN-12	COX	Inflammation/Immunology
COX-2-IN-12 (compound 3b) is a potent and selective inhibitor of *COX-2* with an IC₅₀ of 19.98 μM. COX-2-IN-12 is an anti-inflammatory agent. COX-2-IN-12 shows safety in-vivo acute toxicity study .

HY-146161

COX-2/NO-IN-1	COX NO Synthase	Inflammation/Immunology
COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS), *COX-2* expression and NO (IC₅₀ of 3.52 μM) inhibitor. COX-2/NO-IN-1 has anti-inflammatory effects .

HY-161266

COX-2/NLRP3-IN-1	COX NOD-like Receptor (NLR) NF-κB	Inflammation/Immunology
COX-2/NLRP3-IN-1 (Compound 6k) is a *COX-2/NLRP3* inhibitor with a IC₅₀ of 1.53 μM for COX-2. COX-2/NLRP3-IN-1 exerts anti-inflammatory effects by inhibiting the NF-κB/NLRP3 signaling pathway .

HY-149270

COX-2-IN-31	COX	Inflammation/Immunology
COX-2-IN-31 (compound 7b) is an orally active and dual inhibitor of *COX-2* (IC₅₀=60 nM) and 5-LOX (IC₅₀=1.9 μM). COX-2-IN-31 also inhibits transmembrane hCA IX(K_i=48.9 nM) and hCA XII(K_i=5.8 nM) activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity .

HY-147911

COX-2/PI3K-IN-1	PI3K COX	Inflammation/Immunology Cancer
COX-2/PI3K-IN-1 (compound 5d) is a potent PI3K inhibitor with IC₅₀ value of 1.14 nM. COX-2/PI3K-IN-1 is a selective *COX-2* inhibitor with K_i value of 3.24 nM. COX-2/PI3K-IN-1 has anti-inflammatory and anti-cancer properties.

HY-147912

COX-2/PI3K-IN-2	PI3K COX	Inflammation/Immunology Cancer
COX-2/PI3K-IN-2 (compound 5f) is a potent PI3K inhibitor with IC₅₀ value of 2.78 nM. COX-2/PI3K-IN-2 is a selective *COX-2* inhibitor with K_i value of 3.02 nM. COX-2/PI3K-IN-2 shows anti-inflammatory and anti-cancer properties .

HY-161862

COX-2-IN-44	COX	Inflammation/Immunology
COX-2-IN-44 is a potent and orally active *COX-2* inhibitor with IC₅₀ values of 0.18,1.14 µM for COX-2, COX-1, respectively. COX-2-IN-44 shows anti-inflammatory activity .

HY-163509

COX-2-IN-43	COX Apoptosis	Cancer
COX-2-IN-43 (Compound MYM4) is a *COX-2* inhibitor (IC₅₀: 0.983 and 0.247 μM for COX-1 and COX-2 respectively). COX-2-IN-43 inhibits cancer cell proliferation and colonization, induces apoptosis .

HY-150553

COX-2-IN-28	COX	Inflammation/Immunology
COX-2-IN-28 is a potent and selective *COX-2* inhibitor with IC₅₀ values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively .

HY-146295

COX-2/5-LOX-IN-2	COX	Inflammation/Immunology
COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of *COX-2/5-LOX*. COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC₅₀s of 5.40, 0.01 and 1.78 μM, respectively .

HY-146294

COX-2/5-LOX-IN-1	COX	Inflammation/Immunology
COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of *COX-2/5-LOX*. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC₅₀s of 12.13, 0.4 and 4.96 μM, respectively .

HY-150551

COX-2-IN-27	COX	Inflammation/Immunology
COX-2-IN-27 is a potent and selective *COX-2* inhibitor with IC₅₀ values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity .

HY-U00275

COX-2-IN-1	COX	Inflammation/Immunology
COX-2-IN-1 is potent and slective *COX-2* inhibitor with an IC₅₀ of 3.9 μM.

HY-147692

COX-2-IN-14	COX	Inflammation/Immunology
COX-2-IN-14 (compound 2a) is a potent and selective *COX-2* (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice .

HY-150550

COX-2-IN-26	COX	Inflammation/Immunology
COX-2-IN-26 is a potent, selective and orally active *COX-2* inhibitor with IC₅₀ values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile .

HY-115866

COX-2-IN-6	COX	Cancer
COX-2-IN-6 (compound 10) is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. COX-2-IN-6 selectively targets COX-2 with an IC₅₀ of 0.84 μM and a Ki of 69 nM. COX-2-IN-6 also inhibits COX-2-driven PGE2 synthesis with an IC₅₀ of 0.60 μM .

HY-115976

COX-2-IN-10	COX	Inflammation/Immunology
COX-2-IN-10 is a potent *COX-2* inhibitor. COX-2-IN-10 inhibits the production of PGE₂ in concentration dependent manner (IC₅₀=2.54 µM). COX-2-IN-10 inhibits the expression of iNOS and *COX-2* on mRNA and protein level . COX-2-IN-10 inhibits the production of IL-6, TNF-α and IL-1β .

HY-150721

COX-2-IN-29	COX	Neurological Disease Inflammation/Immunology
COX-2-IN-29 (Compound 15b) is a selective and orally active *COX-2* inhibitor with an IC₅₀ of 0.005 μM .

HY-105304

COX-2-IN-36	COX	Inflammation/Immunology
COX-2-IN-36 (compound 1) is a very potent and specific *COX-2* inhibitor, with an IC₅₀ of 0.4 μM ^[2].

HY-162385

COX-2-IN-42	COX	Inflammation/Immunology
COX-2-IN-42 (Compound T1) is a *COX-2* inhibitor, and protects zebrafish against PTZ-induced neuronal damage .

HY-146198

COX-2-IN-19	COX	Inflammation/Immunology
COX-2-IN-19 (Compound 24) is a potent *COX-2* inhibitor with an IC₅₀ of 1.76 μM. COX-2-IN-19 shows in vivo anti-inflammatory activity .

HY-116947

COX-2-IN-5	COX	Inflammation/Immunology
COX-2-IN-5 (compound 11a) is a potent *COX-2* inhibitor with an IC₅₀ value of 0.65 µM. COX-2-IN-5 has the potential for the research of inflammation .

HY-147809

COX-2-IN-20	COX	Inflammation/Immunology
COX-2-IN-20 (Compound 5d) is a selective and orally active *COX-2* inhibitor with an IC₅₀ of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity .

HY-147963

COX-2-IN-24	COX	Infection
COX-2-IN-24 is an orally active inhibitor of *COX-2* with IC₅₀ value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.

HY-101655

COX-2-IN-2	COX	Inflammation/Immunology
COX-2-IN-2 is a selective and inducible *COX2* inhibitor with an IC₅₀ of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.

HY-146704

COX-2/sEH-IN-1	Epoxide Hydrolase COX	Cardiovascular Disease
COX-2/sEH-IN-1 (Compound 9c) is an orally active, dual *COX-2* and sEH (soluble epoxide hydrolase) inhibitor with IC₅₀ values of 1.24 µM and 0.40 nM against COX-2 and sEH, respectively. COX-2/sEH-IN-1 shows improved anti-inflammatory activity and highly reduced cardiovascular risks .

HY-147815

COX-2-IN-21	COX	Inflammation/Immunology
COX-2-IN-21 (Compound 5c) is a selective and orally active *COX-2* inhibitor with an IC₅₀ of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential .

HY-147719

COX-2-IN-16	COX	Inflammation/Immunology
COX-2-IN-16 (compound 2b) is a potent, selective and orally active *COX-2* inhibitor with an IC₅₀ of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity .

HY-155133

COX-2-IN-34	COX	Inflammation/Immunology
COX-2-IN-34 (compound 8a) is a selective and orally active inhibitor of COX-2 , with an IC₅₀ of 0.42 μM. COX-2-IN-34 has no gastric ulcer toxicity but has anti-inflammatory effects .

HY-169167

COX-2-IN-49	COX	Cancer
COX-2-IN-49 (compound 6c) is a potent **cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀** value of 2.671 µM. COX-2-IN-49 shows antiproliferative activity. COX-2-IN-49 has the potential for the research of cancer .

HY-149355

COX-2-IN-33	COX	Inflammation/Immunology
COX-2-IN-33 (compound 5f) is a *COX-2* inhibitor (IC₅₀=45.5 nM), as well as a potential anti-inflammatory agent. COX-2-IN-33 inhibits in vivo pro-inflammatory cytokine production and keep gastric safety .

HY-161294

COX-2-IN-41	COX	Cancer
COX-2-IN-41 (compound 5e) is a selective inhibitor of COX-2 (IC₅₀=1.74 μM). Compared with COX-1, the selectivity IC₅₀ (COX-1)/IC₅₀(COX-2) =16.32 .

HY-147748

COX-2-IN-17	COX	Inflammation/Immunology
COX-2-IN-17 (compound 10) is a potent and BBB-penetrated *COX-2* (cyclooxygenase-2) inhibitor, with an IC₅₀ of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase .

HY-153762

COX-2-IN-32	NO Synthase NF-κB COX	Inflammation/Immunology
COX-2-IN-32 (Compound 2f) is an iNOS and *COX-2* inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC₅₀: 11.2 μM) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-137011

3,9-Dihydroeucomin	Structural Classification Flavonoids Ledebouria socialis (Baker) Jessop Flavones Source classification Plants Asparagaceae Juss.	COX
3,9-Dihydroeucomin (compound 12) is a natural homoisoflavonoid compound with less COX-2 inhibitory activitys .

HY-129113

α-Chaconine	Alkaloids Piperidine Alkaloids Structural Classification Zea mays L. Pyrrole Alkaloids Classification of Application Fields Gramineae Source classification Plants Inflammation/Immunology Disease Research Fields	COX
α-Chaconine inhibits the expressions of *COX-2, IL-1β, IL-6, and TNF-α* at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and *COX-2* at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N7688

Regaloside B	Monophenols Liliaceae Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Lilium brownie var. viridulum	NO Synthase COX
Regaloside B is a phenylpropanoid isolated from Lilium longiflorum. Regaloside B can inhibit the expression of iNOS and *COX-2*. Regaloside B has anti-inflammatory activity ^[2].

HY-N8167

Plantanone B Kaempferol 3-O-rhamnosylgentiobioside	Flavonols Structural Classification Flavonoids Classification of Application Fields Camellia oleifera Abel. Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Theaceae	COX
Plantanone B is a moderate antioxidant-agent with an IC₅₀ of 169.8±5.2 μM. Plantanone B shows significant ovine COX-1 and moderate COX-2 inhibitory activities. Plantanone B has the potential for inflammation-related diseases research .

HY-N2429

Sphondin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Plants Seriphidium transiliense Inflammation/Immunology Disease Research Fields	COX
Sphondin possesses an inhibitory effect on IL-1β-induced increase in the level of *COX-2* protein and PGE₂ release in A549 cells .

HY-126114

Lupeol acetate 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Umbelliferae Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	COX Interleukin Related
Lupeol acetate, a derivative of Lupeol, suppresses the progression of rheumatoid arthritis (RA) by inhibiting the activation of macrophages and osteoclastogenesis through downregulations of TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B .

HY-N0613

Sauchinone 1 Publications Verification	Structural Classification Saururaceae Classification of Application Fields Saururus chinensis (Lour.) Baill. Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	NF-κB
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .

HY-N8641

Kadsulignan N	Structural Classification Kadsura angustifolia A. C. Smith Source classification Lignans Phenylpropanoids Plants Schisandraceae	HIV COX
Kadsulignan N, a natural product has anti-HIV activity (EC₅₀: 43.56 μM). Kadsulignan N is also a *COX-2* ligand (K_i: 72.24 nM) ^[2].

HY-129113R

α-Chaconine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Zea mays L. Pyrrole Alkaloids Gramineae Source classification Plants	COX
α-Chaconine (Standard) is the analytical standard of α-Chaconine. This product is intended for research and analytical applications. α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N13040

Isoscoparin-7-O-glucoside	Structural Classification Flavonoids Flavones Gramineae Source classification Hordeum vulgare Plants	COX
Isoscoparin-7-O-glucoside is a flavonoid compound found in barley leaves. The total phenolic content (TPC) of isoscoparin-7-O-glucoside is positively correlated with COX-2 inhibitory activity, indicating anti-inflammatory activity. Isoscoparin-7-O-glucoside can be used in the study of inflammation .

HY-N3848

Ermanin	Cardiovascular Disease Flavonols Structural Classification Classification of Application Fields Source classification Plants Curcuma phaeocaulis Valeton Flavonoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Zingiberaceae	Bacterial COX NO Synthase Influenza Virus
Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, *COX-2* activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties ^[2].

HY-100580

Asaraldehyde Asaronaldehyde; Asaraldehyde; 2,4,5-trimethoxy-Benzaldehyde	Acorus tatarinowii Schott Structural Classification Classification of Application Fields Araceae Ketones, Aldehydes, Acids Source classification Plants Inflammation/Immunology Disease Research Fields	COX
Asarylaldehyde (Asaronaldehyde), a *COX-2* inhibitor, significantly inhibits cyclooxygenase II (COX-2) activity with an IC₅₀ value of 100 μg/mL .

HY-W028263

6-Hydroxyflavanone	Structural Classification Flavonoids Flavonones Source classification Muntingia calabura L. Plants Muntingiaceae	COX Opioid Receptor GABA Receptor Lipoxygenase
6-Hydroxyflavanone is a compound that can be isolated from the Muntingia calabura leaves. 6-Hydroxyflavanone targets cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and opioid and GABA-A receptors that has anti-inflammatory and anti-neuropathic pain potential. 6-Hydroxyflavanone can be used for the research of diabetes ^[2].

HY-N0232

Psoralidin 4 Publications Verification	Structural Classification Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Cancer	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial
Psoralidin is a dual inhibitor of *COX-2* and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation ^[2].

HY-15762

Valdecoxib 3 Publications Verification SC 65872	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX Endogenous Metabolite
Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2* and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-N0613R

Sauchinone (Standard)	Structural Classification Saururaceae Saururus chinensis (Lour.) Baill. Terpenoids Source classification Diterpenoids Plants	NF-κB
Sauchinone (Standard) is the analytical standard of Sauchinone. This product is intended for research and analytical applications. Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .

HY-N3480

Isogosferol (+)-Isogospherol; Isogospherol	Structural Classification Source classification Coumarins Ageratina altissima (L.) R.M.King & H.Rob. Phenylpropanoids Plants Umbelliferae	Others
Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2 .

HY-N8413

Chlojaponilactone B	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Chloranthus japonicus Sieb. Plants	Toll-like Receptor (TLR) Reactive Oxygen Species NF-κB
Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α .

HY-N11880

2-O-Sinapoyl makisterone A	Structural Classification Source classification Fibraurea recisa Pierre Plants Menispermaceae Steroids	COX
2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein .

HY-100580R

Asaraldehyde (Standard)	Acorus tatarinowii Schott Structural Classification Araceae Ketones, Aldehydes, Acids Source classification Plants	COX
Asaraldehyde (Standard) is the analytical standard of Asaraldehyde. This product is intended for research and analytical applications. Asarylaldehyde (Asaronaldehyde), a COX-2 inhibitor, significantly inhibits cyclooxygenase II (COX-2) activity with an IC₅₀ value of 100 μg/mL .

HY-N2252

Licarin A (+)-Licarin A	Structural Classification Neurological Disease Classification of Application Fields Saururus chinensis (Lour.) Baill. Source classification Plants Monophenols Saururaceae Simple Phenylpropanols Phenols Phenylpropanoids Inflammation/Immunology Disease Research Fields	TNF Receptor Prostaglandin Receptor COX
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC₅₀=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and *PGD2* production, and *COX-2* expression .

HY-N0767

Isoorientin 5 Publications Verification Homoorientin	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	COX
Isoorientin is a potent inhibitor of *COX-2* with an IC₅₀ value of 39 μM.

HY-N0774

Isofraxidin 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Inflammation/Immunology Disease Research Fields Araliaceae	ERK COX MMP Toll-like Receptor (TLR)
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of *ERK1/2* in hepatoma cells . Isofraxidin attenuates the expression of iNOS and *COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein*-2 (MD-2) complex formation ^[2].

HY-N0232R

Psoralidin (Standard)	Structural Classification Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial
Psoralidin (Standard) is the analytical standard of Psoralidin. This product is intended for research and analytical applications. Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation ^[2].

HY-15762R

Valdecoxib (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	COX Endogenous Metabolite
Valdecoxib (Standard) is the analytical standard of Valdecoxib. This product is intended for research and analytical applications. Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2* and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-N0147

Rutaecarpine 5 Publications Verification Rutecarpine	Alkaloids Structural Classification Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Plants Disease Research Fields Indole Alkaloids Cancer	COX
Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of *COX-2* with an IC₅₀ value of 0.28 μM.

HY-N2925

β-Amyrone β-Amyron	Triterpenes Structural Classification Caprifoliaceae Source classification Plants Sambucus adnata Wall. ex DC.	Fungal COX PPAR
β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of *COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase* and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity ^[2] .

HY-N0774R

Isofraxidin (Standard)	Structural Classification Monophenols Source classification Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	ERK COX MMP Toll-like Receptor (TLR)
Isofraxidin (Standard) is the analytical standard of Isofraxidin. This product is intended for research and analytical applications. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation ^[2].

HY-152120

(±)-Aiphanol Aiphanol	Structural Classification Source classification Phenols Polyphenols Arecaceae Plants Aiphanes aculeata Willd	COX VEGFR
(±)-Aiphanol is a newly discovered stilbenolignan analog. (±)-Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of *COX-1* and *COX-2. The inhibitory effect on COX-1 (IC₅₀ = 1.9 μM) is particularly strong, while the effect on COX-2* (IC₅₀= 9.9 μM) is relatively weak .(±)-Aiphanol effectively inhibits *VEGFR2* (IC₅₀=0.92 µM). (±)-Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (±)-Aiphanol is orally active ^[2].

HY-N0356

(-)-Catechin gallate 1 Publications Verification (-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate	Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae Cancer	COX
(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of *COX-1* and *COX-2* enzymes.

HY-N1380

Guaiacol 2-Methoxyphenol	Structural Classification Human Gut Microbiota Metabolites Monophenols Microorganisms other families Classification of Application Fields Phenols Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX NF-κB Endogenous Metabolite
Guaiacol, a phenolic compound, inhibits LPS-stimulated *COX-2* expression and NF-κB activation . Anti-inflammatory activity .

HY-N0074

Byakangelicol 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt. Inflammation/Immunology Disease Research Fields	COX
Byakangelicol, isolated from Angelica dahurica, inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of **cyclooxygenase-2 (COX-2)** expression and the activity of COX-2 enzyme. Byakangelicol has therapeutic potential as an anti-inflammatory agent on airway inflammation .

HY-N8184

4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone	Dracaena cochinchinensis (Lour.) S. C. Chen Classification of Application Fields Source classification Phenols Polyphenols Agavaceae Plants Disease Research Fields Inflammation/Immunology	COX
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits *COX-1* and *COX-2* inhibitory activity .

HY-W109812

Sinapyl alcohol 1 Publications Verification	Structural Classification Monophenols Microorganisms Source classification Phenols	COX
Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and *COX-2* .

HY-B0167

Salicylic acid 5+ Cited Publications 2-Hydroxybenzoic acid	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Agricultural Research Monophenols Microorganisms other families Ketones, Aldehydes, Acids Phenols Phytohormone Inflammation/Immunology Disease Research Fields Cancer	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-N5015

Rosmanol	Structural Classification Brachyclados megalanthus Speg. Classification of Application Fields Labiatae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	COX
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-N7630

Rehmapicrogenin	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Inflammation/Immunology Disease Research Fields	NO Synthase COX
Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6 .

HY-N0767R

Isoorientin (Standard)	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	COX
Isoorientin (Standard) is the analytical standard of Isoorientin. This product is intended for research and analytical applications. Isoorientin is a potent inhibitor of COX-2 with an IC50 value of 39 μM.

HY-N3866

Esculentic acid	Triterpenes Structural Classification Terpenoids Labiatae Source classification Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	COX
Esculentic acid is a selective *COX-2* inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta ^[2].

HY-N4288

4-Methylesculetin 1 Publications Verification	Structural Classification Nicotiana tabacum L. Classification of Application Fields Source classification Coumarins Phenols Polyphenols Phenylpropanoids Solanaceae Plants Disease Research Fields Cancer	Glutathione Peroxidase Cathepsin Phosphatase
4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases ^[2].

HY-N0481

Roburic acid	Triterpenes Structural Classification Gentiana macrophylla Pall. Classification of Application Fields Terpenoids Source classification Gentianaceae Plants Inflammation/Immunology Disease Research Fields	COX
Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of *COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX-2*, respectively .

HY-N0147R

Rutaecarpine (Standard)	Alkaloids Structural Classification Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Plants Indole Alkaloids	COX
Rutaecarpine (Standard) is the analytical standard of Rutaecarpine. This product is intended for research and analytical applications. Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of COX-2 with an IC50 value of 0.28 μM.

HY-14617

Paradol 3 Publications Verification [6]-Gingerone; [6]-Paradol	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer Zingiberaceae	COX
Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.

HY-N0635

Prim-O-glucosylcimifugin 2 Publications Verification	Structural Classification Natural Products Ophryosporus axilliflorus Hieron. Classification of Application Fields Source classification Umbelliferae Plants Inflammation/Immunology Disease Research Fields	TNF Receptor NO Synthase COX
Prim-O-glucosylcimifugin exerts anti-inflammatory effects through the inhibition of iNOS and *COX-2* expression by through regulating JAK2/STAT3 signaling.

HY-N2266

Benzoylgomisin O	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Inflammation/Immunology Disease Research Fields	COX
Benzoylgomisin O isolated from Schisandra rubriflora, has inhibitory activity against 15-LOX, *COX-1* and *COX-2* enzymes and anti-inflammatory activity .

HY-126121

2-Hydroxy Ibuprofen (±)-2-Hydroxy Ibuprofen	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	COX
2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-N2599

Taraxerol acetate	Triterpenes Structural Classification Classification of Application Fields Terpenoids Astragalus oleifolius DC. Source classification Plants Compositae Disease Research Fields Cancer	COX Apoptosis
Taraxerol acetate is a *COX-1* and *COX-2* inhibitor with IC₅₀ values of 116.3 μM and 94.7 μM, respectively. Taraxerol acetate the has the anticancer potential and induces cell apoptosis .

HY-N10303

Withangulatin A	Structural Classification Cardiacglycosides Source classification Physalis angulata L. Plants Solanaceae Steroids	COX Parasite
Withangulatin A is a selective cyclooxygenase-2 (COX-2) inhibitor. Withangulatin A can be isolated from Physalis angulata L. Withangulatin A has anti-tumor, trypanocidal activity and anti-inflammatory function .

HY-N0929

Hexahydrocurcumin	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Curcuma longa Disease Research Fields Zingiberaceae Cancer	COX Reactive Oxygen Species
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active *COX-2* inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities ^[2].

HY-N11624

Axinelline A	Structural Classification Microorganisms Source classification Phenols Polyphenols	COX
Axinelline A is a potent *COX* inhibitor with IC₅₀s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity .

Cat. No.	Product Name	Chemical Structure

HY-B0360S

Rebamipide-d4
Rebamipide-d₄ is deuterium labeled Rebamipide. Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner[1].

HY-B0167S1

Salicylic acid-13C6
Salicylic acid- ¹³C₆ is the ¹³C-labeled Salicylic acid (HY-B0167). Salicylic acid is a precursor to and a metabolite of Aspirin (HY-14654), can inhibit cyclo-oxygenase-2 (COX-2) activity[1][2].

HY-78131AS

(S)-(+)-Ibuprofen D3
(S)-(+)-Ibuprofen-d₃ is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].

HY-15321S

Etoricoxib-d4 1 Publications Verification
Etoricoxib-d₄ is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-17357S

Nepafenac-d5
Nepafenac-d₅ is the deuterium labeled Nepafenac, which is a selective COX-2 inhibitor.

HY-B0363S

Nimesulide D5
Nimesulide-d₅ is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties[1][2].

HY-14397S2

Indometacin-d7
Indometacin-d₇ is deuterated labeled Indomethacin (HY-14397). Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research ^[2] .

HY-B0008S

Sulindac-d3
Sulindac-d₃ is deuterium labeled Sulindac. Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2.

HY-17372S

Rofecoxib-d5
Rofecoxib-d₅ is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells)[1][2].

HY-15762S

Valdecoxib-d3
Valdecoxib-d₃ is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain[1][2].

HY-15321S1

Etoricoxib-13C,d3
Etoricoxib- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoricoxib. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-B0808S1

Oxaprozin-d5
Oxaprozin-d₅ is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.

HY-B0335S1

Tolfenamic acid-13C6
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-15321S2

Etoricoxib-d3
Etoricoxib-d₃ is the deuterium labeled Etoricoxib[1]. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood[2][3][4].

HY-B0335S

Tolfenamic Acid-D4
Tolfenamic acid-d₄ is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1[1][2].

HY-14670S

Firocoxib-d4
Firocoxib-d₄ (ML 1785713-d4) is the deuterium labeled Firocoxib. Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC50 of 7.5 μM). Firocoxib has anti-inflammatory effects[1].

HY-14397S

Indomethacin-d4
Indomethacin-d₄ is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

HY-14397S1

Indomethacin-d4 Methyl Ester
Indomethacin-d₄ Methyl Ester is the deuterium labeled Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

HY-B0619S1

Zaltoprofen-13C,d3
Zaltoprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Zaltoprofen. Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain[1][2][3].

HY-15036S1

Diclofenac-13C6
Diclofenac- ¹³C₆ is the ¹³C₆ labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15037S2

Diclofenac-13C6 sodium

Diclofenac- ¹³C₆ (Sodium) is the ¹³C₆ labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-B0367S

Lornoxicam-d4
Lornoxicam-d₄ is the deuterium labeled Lornoxicam. Lornoxicam (Chlortenoxicam), a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory agent (NSAID).

HY-15037S1

Diclofenac-d4 sodium

Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-15036S

Diclofenac-d4
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-14654S

Aspirin-d3
Aspirin-d₃ is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.

HY-78131S

Ibuprofen-d3
Ibuprofen-d₃ is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM[1].

HY-15037S

Diclofenac-13C6 sodium heminonahydrate

Diclofenac- ¹³C₆ (sodium heminonahydrate) is the ¹³C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-14398S1

Celecoxib-d3
Celecoxib-d₃ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

HY-14398S

Celecoxib-d7
Celecoxib-d₇ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

HY-B0167S

Salicylic acid-d6
Salicylic acid-d₆ is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].

HY-B0559S

Nabumetone-d3
Nabumetone-d₃ is the deuterium labeled Nabumetone. Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metabolite 6MNA.

HY-14654S1

Aspirin-d4
Aspirin-d₄ is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL[1][2].

HY-N1380S1

Guaiacol-d3
Guaiacol-d₃ is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity[1].

HY-N0356S

(+/-)-Catechin Gallate-13C3
(+/-)-Catechin Gallate- ¹³C₃ is the ¹³C-labeled (-)-Catechin gallate. (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.

HY-N1380S

Guaiacol-d7
Guaiacol-d₇ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S3

Guaiacol-d4
Guaiacol-d₄ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S2

Guaiacol-13C6
Guaiacol- ¹³C₆ is the ¹³C labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S4

Guaiacol-d4-1
Guaiacol-d₄-1 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-78131S1

Ibuprofen-13C,d3
Ibuprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Ibuprofen. Ibuprofen is an anti-inflammatory agent targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.

HY-B0261S1

Meloxicam-d3-1
Meloxicam-d₃-1 is the deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-B0253S

Piroxicam-d3
Piroxicam-d₃ is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively [1].

HY-W109812S

Sinapyl alcohol-d3
Sinapyl alcohol-d₃ is the deuterated labeled Sinapyl alcohol (HY-W109812). Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and *COX-2* .

HY-B0261S

Meloxicam-d3
Meloxicam-d₃ is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively[1].

HY-B0253S1

Piroxicam-d4
Piroxicam-d₄ is the deuterium labeled Piroxicam. Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively.

HY-B0261S2

Meloxicam-13C,d3
Meloxicam- ¹³C,d₃ is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-66005S2

Acetaminophen-d7
Acetaminophen-d₇ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

HY-B0227S1

Ketoprofen-d4
Ketoprofen-d₄ is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

HY-B0227S

Ketoprofen-d3
Ketoprofen-d₃ is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

HY-118139S

Celecoxib-d4
Celecoxib-d₄ is the deuterium labeled Desmethyl Celecoxib. Desmethyl Celecoxib (compound 3b) is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50=32 nM) with anti-inflammatory activities. Desmethyl Celecoxib is an analog of Celecoxib and with the optimal yield of 75%[1].

HY-B1227S

Carprofen-d3
Carprofen-d₃ is the deuterium labeled Carprofen. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

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