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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115433

α-Muricholic acid 1 Publications Verification	Endogenous Metabolite	Metabolic Disease Endocrinology
α-Muricholic acid is the most abundant primary bile acid in rodents .

HY-D1109

5(6)-SFX ,SE	Fluorescent Dye	Others
5(6)-SFX ,SE (Compound SFX-SE) is a fluorescent dye for labeling primary amines and nascent proteins .

HY-W014332

1,3-Diphenylguanidine	Biochemical Assay Reagents	Others
1,3-diphenylguanidine is the primary and secondary accelerator in the vulcanization of rubber and is found in the rubber industry .

HY-W130610

Stearamide	Liposome Akt mTOR	Others
Stearamide is a primary fatty acid amide. Stearamide displays cytotoxic and ichthytoxic activity .

HY-106007

Trabodenoson INO-8875	Adenosine Receptor	Inflammation/Immunology
Trabodenoson (INO-8875), an adenosine mimetic, is a highly selective Adenosine A1 receptor agonist. Trabodenoson (INO-8875) is used in the study for Primary Open-Angle Glaucoma .

HY-D2776

Primary antibody and secondary antibody eluent, specially for mIHC experiments	Biochemical Assay Reagents	Others
Primary antibody and secondary antibody eluent, specially for mIHC experiments is an eluent used for mIHC (multiple immunohistochemistry).

HY-Y0319C1

Calcium acetate, United States Pharmacopeia (USP) Reference Standard Calcium acetate (Pharmaceutical Primary standard, USP)	Biochemical Assay Reagents	Metabolic Disease
Calcium acetate, United States Pharmacopeia (USP) Reference Standard (Calcium acetate (Pharmaceutical primary standard, USP)), a phosphate binder that can reduce phosphorus content, United States Pharmacopeia (USP) reference standard .

HY-Y0317E

Sodium sulfate anhydrous, United States Pharmacopeia (USP) Reference Standard Disodium sulfate (Pharmaceutical Primary standard, USP)	Biochemical Assay Reagents	Others
Sodium sulfate anhydrous (Disodium sulfate), can be widely used as a desiccant, pH regulator, etc. in biochemical experiments. It is a reference standard grade of the United States Pharmacopeia (USP), pharmaceutical primary standard.

HY-115433R

α-Muricholic acid (Standard)	Endogenous Metabolite	Metabolic Disease Endocrinology
α-Muricholic acid (Standard) is the analytical standard of α-Muricholic acid. This product is intended for research and analytical applications. α-Muricholic acid is the most abundant primary bile acid in rodents .

HY-131479

Threo-dihydrobupropion hydrochloride	Drug Metabolite	Neurological Disease
Threo-dihydrobupropion hydrochloride is a primary metabolite of Bupropion. Threo-dihydrobupropion hydrochloride can be used for the research of the depression, behavioral, and biochemistry .

HY-A0178A

Isothipendyl hydrochloride NSC 169186	Endogenous Metabolite Histamine Receptor	Inflammation/Immunology
Isothipendyl hydrochloride (), an azaphenothiazine derivative, is a potent histamine 1 (H1) receptor antagonist.othipendyl is a primary metabolite .

HY-B1580B

Calcium propionate, United States Pharmacopeia (USP) Reference Standard Bioban-C (Pharmaceutical Primary standard, USP)	Biochemical Assay Reagents	Metabolic Disease
Calcium propionate, United States Pharmacopeia (USP) Reference Standard is an orally active auxiliary agent for preventing milk fever and improving the health of dairy cows. Calcium propionate can be used for research on dairy cow milk fever and subclinical hypocalcemia. Calcium propionate is a reference standard grade of the United States Pharmacopeia (USP) and a primary pharmaceutical standard .

HY-A0178

Isothipendyl AY 56012	Histamine Receptor Endogenous Metabolite	Inflammation/Immunology
Isothipendyl (AY 56012), an azaphenothiazine derivative, is a potent histamine 1 (H1) receptor antagonist. Isothipendyl is a primary metabolite .

HY-Y1269I

Ammonium chloride, United States Pharmacopeia (USP) Reference Standard Salmiac (Pharmaceutical Primary standard, USP)	Biochemical Assay Reagents Autophagy	Cancer
Ammonium chloride United States Pharmacopeia (USP) Reference Standard (Salmiac, Pharmaceutical primary standard, USP) is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride is also a lysosome inhibitor .

HY-106591A

4-Vinylcyclohexene dioxide Vinylcyclohexene diepoxide	Apoptosis	Cardiovascular Disease
4-Vinylcyclohexene dioxide is a metabolite of 4-vinylcyclohexene that can specifically destroy oocytes in primordial and primary follicles of rats and mice. 4-Vinylcyclohexene dioxide induces apoptosis in rat cells is associated with activation of a caspase-mediated cascade .

HY-137397

8-Hydroxyefavirenz 8-OH-EFV	Apoptosis JNK	Cancer
8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer . 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-134338

Ipflufenoquin	Parasite	Others
Ipflufenoquin is an insecticide with the potential to control primary infection with apple scab. Ipflufenoquin should be applied between half an inch of green and fruit set .

HY-W014332R

1,3-Diphenylguanidine (Standard)	Biochemical Assay Reagents	Others
1,3-Diphenylguanidine (Standard) is the analytical standard of 1,3-Diphenylguanidine. This product is intended for research and analytical applications. 1,3-diphenylguanidine is the primary and secondary accelerator in the vulcanization of rubber and is found in the rubber industry .

HY-A0178AR

Isothipendyl (hydrochloride) (Standard)	Endogenous Metabolite Histamine Receptor	Inflammation/Immunology
Isothipendyl (hydrochloride) (Standard) is the analytical standard of Isothipendyl (hydrochloride). This product is intended for research and analytical applications. Isothipendyl hydrochloride (), an azaphenothiazine derivative, is a potent histamine 1 (H1) receptor antagonist.othipendyl is a primary metabolite .

HY-133994

Octakis-(6-bromo-6-deoxy)-γ-cyclodextrin	Drug Intermediate	Others
Octakis-(6-bromo-6-deoxy)-γ-cyclodextrin is a perbrominated γ-cyclodextrin at the primary side. Octakis-(6-bromo-6-deoxy)-γ-cyclodextrin is also a commonly used intermediate in the modification of cyclodextrin .

HY-N1867

trans-Cinnamyl alcohol	PPAR	Metabolic Disease
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite .

HY-123568

PBI-1393 BCH-1393	TNF Receptor	Cancer
PBI-1393 (BCH-1393) is an anticancer agent that enhances Th1 type cytokine production and primary T cell activation .

HY-139070

D-Glyceric acid	Endogenous Metabolite	Metabolic Disease
D-Glyceric acid is an endogenous metabolite present in urine that can be used for the research of primary hyperoxaluria type I and glutaric acidemia type 2 .

HY-P99047

Simtuzumab AB 0024; GS 6624	Monoamine Oxidase	Inflammation/Immunology Cancer
Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab can be used for the research of primary sclerosing cholangitis (PSC) .

HY-153450

JBI-589	Protein Arginine Deiminase	Cancer
JBI-589 is a non-covalent PAD4 isoform-selective inhibitor with oral bioavailability. JBI-589 reduces CXCR2 expression and blocks neutrophil chemotaxis. JBI-589 reduces primary tumor and metastases, and enhances the anti-tumor effect of checkpoint inhibitors. JBI-589 can be used in cancer research .

HY-121385

Hydroxy bosentan Ro 48-5033	Endogenous Metabolite	Cardiovascular Disease
Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities .

HY-131772

2-AHA-cAMP	Fluorescent Dye	Others
2-AHA-cAMP is an analogue of natural signal molecule cAMP and an activator of cAMP-dependent protein kinase. 2-AHA-cAMP has a free terminal primary amino group, which can be used for coupling to gels or fluorescent dyes .

HY-N12201

Funiculosin	Antibiotic Fungal	Infection
Funiculosin is a neutral lipophilic antibiotic that inhibits DNA and RNA viruses. Funiculosin also has antifungal activity. Funiculosin inhibits infections caused by pathogenic fungi in primary chicken embryo fibroblasts .

HY-110134

S07662	Constitutive Androstane Receptor	Metabolic Disease
S07662 is a human constitutive androstane receptor (hCAR) inhibitor with an IC₅₀ of 0.7 μM. S07662 recruits the corepressor NCoR in cell-based assays and attenuate the expression of CYP2B6 mRNA in human primary hepatocytes induced by phenytoin (HY-B0448) and CITCO (HY-103244) .

HY-D1078

5(6)-Carboxy-2',7'-dichlorofluorescein diacetate	Reactive Oxygen Species	Others
5(6)-Carboxy-2',7'-dichlorofluorescein diacetate is a cell permeant fluorescent indicator. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate can be used to assess reactive oxygen species (ROS) generation within human neuronal-glial (HNG) cells in primary co-culture

HY-170818

Grp94 Inhibitor-3	HSP	Cancer
Grp94 Inhibitor-3 (Compound C6) is a selective glucose regulated protein 94 (Grp94) inhibitor with an affinity of 5.52 μM. Grp94 Inhibitor-3 is promising for research of primary open-angle glaucoma and metastatic cancer .

HY-109120

Odevixibat 3 Publications Verification A4250	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-139070A

D-Glyceric acid sodium	Endogenous Metabolite	Metabolic Disease
D-Glyceric acid sodium is the sodium form of D-Glyceric acid (HY-139070A). D-Glyceric acid is an endogenous metabolite present in urine that can be used for the research of primary hyperoxaluria type I and glutaric acidemia type 2 .

HY-D1692

BODIPY 650/665 NHS ester	Fluorescent Dye	Others
BODIPY 650/665 NHS ester is bright, far-red fluorescent dye that can be used to label the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules . Ex / Em = 646 / 660 nm

HY-D1372

Cyanine3 amine hydrochloride	Fluorescent Dye	Others
Cyanine3 amine hydrochloride, an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine hydrochloride has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λ_ex=555 nm, λ_em=570 nm) .

HY-116374A

Glycolithocholic acid sodium 1 Publications Verification Lithocholylglycine sodium	Endogenous Metabolite	Metabolic Disease
Glycolithocholic acid (Lithocholylglycine) sodium is the sodium salt of Glycolithocholic acid. Glycolithocholic acid is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-117695

AQC 3 Publications Verification 6-Aminoquinolyl-N-hydroxysccinimidyl carbamate	Fluorescent Dye	Others
AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) is a reagent used for amino acid or protein sequence analysis by HPLC with fluorescence detection. AQC reacts with primary and secondary amino acids to yield fluorescent derivates, allowing amino acid detection at under-picomolar levels .

HY-D1372A

Cyanine3 amine TFA	Fluorescent Dye	Others
Cyanine3 amine (TFA), an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine (TFA) has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λ_ex=555 nm, λ_em=570 nm) .

HY-109120S

Odevixibat-d5 A4250-d₅	Apical Sodium-Dependent Bile Acid Transporter Isotope-Labeled Compounds	Metabolic Disease
Odevixibat-d₅ is deuterated labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-109120S1

Odevixibat-13C6 A4250-¹³C₆	Apical Sodium-Dependent Bile Acid Transporter Isotope-Labeled Compounds	Metabolic Disease
Odevixibat- ¹³C₆ is ¹³C labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-153812

AST 7062601 AST070	Anion Exchangers	Metabolic Disease
AST 7062601 (AST070) is a Ucp1 inducer that strongly induces endogenous Ucp1 expression in primary mouse brown adipocytes. Ucp1 refers to uncoupling protein, found in brown and beige fat cells. In mammals, UCP1 oxidizes fatty acids and uncouples ATP production in mitochondria to promote energy dissipation as heat. AST 7062601 can be used to study thermogenic, uncoupled respiration .

HY-P1258A

PSI TFA Proteasome Inhibitor 1 TFA; Z-Ile-Glu(OtBu)-Ala-Leu-CHO TFA	Proteasome	Infection Cancer
PSI (TFA) is a potent proteasome inhibitor. PSI (TFA) inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI (TFA) can be used for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas .

HY-P1258

PSI Proteasome Inhibitor 1; Z-Ile-Glu(OtBu)-Ala-Leu-CHO	Proteasome	Infection Cancer
PSI (Proteasome Inhibitor 1) is a potent proteasome inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas .

HY-118431

DMABA NHS ester	Biochemical Assay Reagents	Others
DMABA NHS ester can chemically react with the primary amine groups of the major phospholipid component of the cell membrane, Phosphatidylethanolamine (PE). Through precursor ion scanning, all PE subclasses labeled with DMABA can be detected. DMABA NHS ester can be used in combination with isotope-labeled compounds such as DMABA-d6 NHS ester, DMABA-d10 NHS ester, and DMABA-d4 NHS ester to observe changes in the distribution of PE lipids and the formation of novel PE lipid products .

HY-116374

Glycolithocholic acid 1 Publications Verification Lithocholylglycine	Endogenous Metabolite	Inflammation/Immunology
Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-151373

MurA-IN-2	Bacterial	Infection
MurA-IN-2 (compound 37), a chloroacetamide fragment containing a primary aliphatic amine, is a potent MurA inhibitor with an IC₅₀ value of 39 μM. MurA-IN-2 has antibacterial activity and inhibits the bacterial cell wall synthesis .

HY-120044

L-739749	Farnesyl Transferase Ras	Cancer
L-739749 is a farnesyl transferase inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro .

HY-19694

BRD7552	Insulin Receptor	Endocrinology
BRD7552, a potent PDX1 transcription factor inducer, upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases insulin expression. PDX1 is a key transcription factor involved in pancreas development and β cell function .

HY-100962A

AG 99 Tyrphostin 46; Tyrphostin AG 99	Tyrosinase	Cancer
AG 99 (Tyrphostin 46), a tyrphostin derivative, is a tyrosine kinase inhibitor that increases sister chromatid exchange frequency in transformed CHO-K1 and primary CHE cells. AG 99 is promising for research of proliferative diseases .

HY-125348

6α-Hydroxy paclitaxel	Drug Metabolite	Cancer
6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on *organic anion–transporting polypeptides 1B1/SLCO1B1* (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3**. 6α-Hydroxy paclitaxel can be used for the research of cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-115433

α-Muricholic acid 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
α-Muricholic acid is the most abundant primary bile acid in rodents .

HY-W130610

Stearamide	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Liposome Akt mTOR
Stearamide is a primary fatty acid amide. Stearamide displays cytotoxic and ichthytoxic activity .

HY-N1867

trans-Cinnamyl alcohol	Structural Classification Natural Products Source classification Rosaceae Plants	PPAR
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite .

HY-116374

Glycolithocholic acid 1 Publications Verification Lithocholylglycine	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite
Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-13680

Meisoindigo 1 Publications Verification Dian III; N-Methylisoindigotin; Natura-α	Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Cancer	Apoptosis
Meisoindigo (Dian III), a derivative of Indirubin (HY-N0117), halts the cell cycle at the G0/G1 phase and induces apoptosis in primary acute myeloid leukemia (AML) cells. Meisoindigo exhibits high antitumor activity .

HY-115433R

α-Muricholic acid (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Endogenous Metabolite
α-Muricholic acid (Standard) is the analytical standard of α-Muricholic acid. This product is intended for research and analytical applications. α-Muricholic acid is the most abundant primary bile acid in rodents .

HY-A0178

Isothipendyl AY 56012	Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields	Histamine Receptor Endogenous Metabolite
Isothipendyl (AY 56012), an azaphenothiazine derivative, is a potent histamine 1 (H1) receptor antagonist. Isothipendyl is a primary metabolite .

HY-139070

D-Glyceric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D-Glyceric acid is an endogenous metabolite present in urine that can be used for the research of primary hyperoxaluria type I and glutaric acidemia type 2 .

HY-121385

Hydroxy bosentan Ro 48-5033	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities .

HY-N12201

Funiculosin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Fungal
Funiculosin is a neutral lipophilic antibiotic that inhibits DNA and RNA viruses. Funiculosin also has antifungal activity. Funiculosin inhibits infections caused by pathogenic fungi in primary chicken embryo fibroblasts .

HY-N6662

(+)-Longifolene	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(+)-Longifolene is a sesquiterpenoid and a metabolite in rabbits. (+)-Longifolen is converted to primary, secondary or tertiary alcohols in rabbits, among which the primary alcohol is predominant .

HY-N2334A

Glycochenodeoxycholic acid sodium salt 4 Publications Verification Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Endogenous Metabolite Apoptosis STAT BCL6 Interleukin Related Caspase
Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .

HY-N2334

Glycochenodeoxycholic acid 4 Publications Verification Chenodeoxycholylglycine	Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Endogenous Metabolite Apoptosis STAT BCL6 Interleukin Related Caspase
Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .

HY-W145498

D-(+)-Cellotetraose Cellotetraose	Structural Classification Natural Products Polysaccharides Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Saccharides	Drug Metabolite
D-(+)-Cellotetraose (Cellotetraose) is a primary hydrolysis product of cellulose .

HY-B1178

Cotinine 1 Publications Verification (-)-Cotinine; (S)-Cotinine; NIH-10498	Alkaloids Structural Classification Pyrrole Alkaloids Nicotiana tabacum L. Classification of Application Fields Source classification Other Diseases Pyridine Alkaloids Solanaceae Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite nAChR
Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases .

HY-122141

Glycohyocholic acid GHCA	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Glycohyocholic acid(GHCA) is a glycine-conjugated form of the primary bile acid hyocholic acid .

HY-N2334R

Glycochenodeoxycholic acid (Standard) Chenodeoxycholylglycine (Standard)	Structural Classification Microorganisms Source classification Endogenous metabolite Steroids	Endogenous Metabolite Apoptosis STAT BCL6 Interleukin Related Caspase
Glycochenodeoxycholic acid (Standard) is the analytical standard of Glycochenodeoxycholic acid. This product is intended for research and analytical applications. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC)[1][2][3][4].

HY-N2334AR

Glycochenodeoxycholic acid sodium salt (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Endogenous Metabolite Apoptosis STAT BCL6 Interleukin Related Caspase
Glycochenodeoxycholic acid sodium salt (Standard) is the analytical standard of Glycochenodeoxycholic acid sodium salt. This product is intended for research and analytical applications. Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .

HY-76847

Chenodeoxycholic Acid Maximum Cited Publications 16 Publications Verification CDCA	Structural Classification Human Gut Microbiota Metabolites Microorganisms Other disease Classification of Application Fields Source classification Disease markers Endogenous metabolite Disease Research Fields Steroids Cancer	FXR Endogenous Metabolite Autophagy
Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

HY-N0181

Ergosterol 3 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite
Ergosterol is the primary sterol found in fungi, with antioxidative, anti-proliferative, and anti-inflammatory effects.

HY-76847A

Chenodeoxycholic acid sodium Maximum Cited Publications 16 Publications Verification CDCA sodium	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Cancer	FXR Autophagy Endogenous Metabolite
Chenodeoxycholic acid sodium is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

HY-W011956

6-Hydroxymelatonin	Structural Classification Natural Products Monophenols Source classification Phenols Endogenous metabolite	Drug Metabolite Endogenous Metabolite
6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by cytochrome P450 (CYP) 1A2.

HY-W004296

1-Heptadecanol	Structural Classification Natural Products Classification of Application Fields Solena heterophylla Lour. Source classification Cucurbitaceae Plants Inflammation/Immunology Disease Research Fields	Bacterial
1-Heptadecanol is a long-chain primary alcohol with antibacterial activity from Solena amplexicaulis leaves .

HY-33914

4-Hydroxymethylpyrazole	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Drug Metabolite Endogenous Metabolite
4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase .

HY-N6946

Mitraphylline	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Structural Classification Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Inflammation/Immunology Disease Research Fields	NF-κB
Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils .

HY-N0324A

Cholic acid sodium 10+ Cited Publications Sodium cholate	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active .

HY-N0324

Cholic acid 10+ Cited Publications	Structural Classification Human Gut Microbiota Metabolites Microorganisms Other disease Classification of Application Fields Source classification Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .

HY-N0324B

Cholic acid sodium hydrate	Source classification Endogenous metabolite Steroids	Endogenous Metabolite
Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active .

HY-76847R

Chenodeoxycholic Acid (Standard) CDCA (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Other disease Classification of Application Fields Source classification Disease markers Endogenous metabolite Disease Research Fields Steroids Cancer	FXR Endogenous Metabolite Autophagy
Chenodeoxycholic Acid (Standard) is the analytical standard of Chenodeoxycholic Acid. This product is intended for research and analytical applications. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

HY-N0181R

Ergosterol (Standard) Ergosterin(Standard); Provitamin D(Standard); Provitamin D2 (Standard)	Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite
Ergosterol (Standard) is the analytical standard of Ergosterol. This product is intended for research and analytical applications. Ergosterol is the primary sterol found in fungi, with antioxidative, anti-proliferative, and anti-inflammatory effects.

HY-W587803R

Propionylglycine (Standard)	Microorganisms Source classification	Others
Ergosterol (Standard) is the analytical standard of Ergosterol. This product is intended for research and analytical applications. Ergosterol is the primary sterol found in fungi, with antioxidative, anti-proliferative, and anti-inflammatory effects.

HY-N6637

Senecionine N-oxide	Pterogyne nitens Tul. Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Plants Compositae Disease Research Fields Cancer	Others
Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity .

HY-B0125

Ofloxacin 5+ Cited Publications Hoe-280	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus
Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-N12719

Isocampneoside I	Structural Classification Source classification Phenols Polyphenols Orobanchaceae Cistanche tubulosa (Schenk) Wight Plants	Others
Isocampneoside I is an acylated phenethyl oligosaccharide that can be isolated from Cistanche deserticola (Orobanchaceae). Isocampneoside I inhibits D-galactose-induced cytotoxicity and protects primary hepatocytes in mice .

HY-W032022

1-Hexanol	Structural Classification Natural Products Microorganisms Animals Classification of Application Fields Source classification Other Diseases Disease Research Fields	Biochemical Assay Reagents Mitochondrial Metabolism
1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-167884

PF-1367550	Structural Classification Alkaloids Aristolochia debilis Sieb. et Zucc. Source classification Plants Aristolochiaceae	JAK
PF-1367550 is a pan-JAK inhibitor. PF-1367550 can decrease the levels of release of CXCL9, CXCL10 and CXCL11 from primary airway epithelial cells .

HY-N4053

Heraclenin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Seriphidium transiliense Inflammation/Immunology Disease Research Fields	Nuclear Factor of activated T Cells (NFAT)
Heraclenin, a natural furanocoumarin, significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT) .

HY-W002112

(±)-Nornicotine Nornicotine	Structural Classification Alkaloids Pyrrole Alkaloids Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields	Endogenous Metabolite Drug Metabolite
(±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .

HY-N6946R

Mitraphylline (Standard)	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants	NF-κB
Mitraphylline (Standard) is the analytical standard of Mitraphylline. This product is intended for research and analytical applications. Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils .

HY-N13159

Goodyeroside A	Structural Classification Crocus sativus Linn. Iridaceae Source classification Plants Saccharides Monosaccharides	Others
Goodyeroside A is a glycoside compound derived from the plant Goodyera that exhibits significant hepatoprotective activity. It can inhibit liver damage induced by carbon tetrachloride (HY-Y0298) in primary cultured rat hepatocytes .

HY-19825

Rebeccamycin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	Topoisomerase ADC Cytotoxin Antibiotic
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II .

HY-W011956R

6-Hydroxymelatonin (Standard)	Structural Classification Natural Products Monophenols Source classification Phenols Endogenous metabolite	Drug Metabolite Endogenous Metabolite
6-Hydroxymelatonin (Standard) is the analytical standard of 6-Hydroxymelatonin. This product is intended for research and analytical applications. 6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by cytochrome P450 (CYP) 1A2.

HY-W130610R

Stearamide (Standard)	Structural Classification Natural Products Microorganisms Source classification	Liposome Akt mTOR
Ginsenoside C-K (Standard) is the analytical standard of Ginsenoside C-K. This product is intended for research and analytical applications. Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC50s of 32.0±3.6 μM and 63.6±4.2 μM, respectively.

HY-W018035

DL-Glyceric Acid (20% in water) 1 Publications Verification Glyceric Acid (20% in Water,ca.2 mol/L)	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
DL-Glyceric Acid (20% in water) is a metabolite of plants and mammals and exists in two configurations, D and L .

HY-N1931

Epifriedelanol	Triterpenes Structural Classification Classification of Application Fields Anti-aging Terpenoids Source classification Plants Compositae Erythrina latissima E. Mey. Disease Research Fields Cancer	Caspase PARP Apoptosis MDM-2/p53
Epifriedelanol is a triterpenoid found in the root bark of Ulmus davidiana. Epifriedelanol induces apoptosis in DU145 cells. Epifriedelanol has antitumor and anti-inflammatory activities. Epifriedelanol inhibits cellular senescence in human primary cells .

HY-101397R

Allopurinol riboside (Standard)	Alkaloids Structural Classification Source classification Endogenous metabolite Indole Alkaloids	Reference Standards Parasite Drug Metabolite Endogenous Metabolite
Cholic acid (Standard) is the analytical standard of Cholic acid. This product is intended for research and analytical applications. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .

HY-N4299

Caesappanin C	Classification of Application Fields Leguminosae Caesalpinia sappan L. Source classification Other Phenylpropanoids Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Disease Research Fields	Others
Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration .

HY-N0324R

Cholic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Other disease Classification of Application Fields Source classification Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Cholic acid (Standard) is the analytical standard of Cholic acid. This product is intended for research and analytical applications. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .

HY-N0324AR

Cholic acid sodium (Standard) Sodium cholate (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Endogenous Metabolite
Cholic acid (sodium) (Standard) is the analytical standard of Cholic acid (sodium). This product is intended for research and analytical applications. Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active[1][2].

HY-B0125R

Ofloxacin (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus
Ofloxacin (Standard) is the analytical standard of Ofloxacin. This product is intended for research and analytical applications. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

Cat. No.	Product Name	Chemical Structure

HY-103252S

Monomethyl fumarate-d3 1 Publications Verification
Monomethyl fumarate-d₃ is a deuterium labeled Monomethyl fumarate. Monomethyl fumarate is the primary metabolite of dimethyl fumarate[1].

HY-76847S

Chenodeoxycholic Acid-d4
Chenodeoxycholic Acid-d₄ is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

HY-76847S3

Chenodeoxycholic acid-d5
Chenodeoxycholic acid-d₅ is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

HY-76847S2

Chenodeoxycholic acid-13C
Chenodeoxycholic acid- ¹³C is the ¹³C-labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

HY-109120S

Odevixibat-d5
Odevixibat-d₅ is deuterated labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-109120S1

Odevixibat-13C6
Odevixibat- ¹³C₆ is ¹³C labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-N6662S

(+)-Longifolene-13C,d2
(+)-Longifolene- ¹³C,d₂ is the ¹³C- and deuterium labeled (+)-Longifolene (HY-N6662). (+)-Longifolene is a sesquiterpenoid and a metabolite in rabbits. (+)-Longifolen is converted to primary, secondary or tertiary alcohols in rabbits, among which the primary alcohol is predominant .

HY-W751098

Aldosterone-13C3
Aldosterone- ¹³C₃ is a ¹³C-labeled Aldosterone (HY-113313). Aldosterone is a primary mineralocorticoid and steroid hormone.

HY-76847S1

Chenodeoxycholic Acid-d9
Chenodeoxycholic Acid-d₉ is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

HY-13582S1

Carbendazimb-d3
Carbendazimb-d₃ is the deuterium labeled Ofloxacin. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase.

HY-N0324S

Cholic acid-d4 1 Publications Verification
Cholic acid-d₄ is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

HY-76847S4

Chenodeoxycholic acid-d2
Chenodeoxycholic acid-d₂ (CDCA-d₂) is deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

HY-N0324S1

Cholic acid-d5
Cholic acid-d₅ is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

HY-115433S

α-Muricholic acid-d5
α-Muricholic acid-d₅ is the deuterium labeled α-Muricholic acid. α-Muricholic acid is the most abundant primary bile acid in rodents[1][2].

HY-115433S1

α-Muricholic acid-d4
α-Muricholic acid-d₄ is the deuterium labeled α-Muricholic acid. α-Muricholic acid is the most abundant primary bile acid in rodents[1][2].

HY-12388AS

N-Desmethyl clomipramine-d3 hydrochloride
N-Desmethyl Clomipramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]

HY-N0324S2

Cholic acid-13C
Cholic acid- ¹³C is the ¹³C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

HY-113313S2

Aldosterone-d4
Aldosterone-d₄ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by t

HY-B0125S1

Ofloxacin-d8
Ofloxacin-d₈ (Hoe-280-d8) is the deuterium labeled Ofloxacin. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase.

HY-N0709S

Coumarin-d4
Coumarin-d₄ is the deuterium labeled Coumarin. Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities.

HY-W082452S

N-Boc-N-methoxy-N-methyl-L-phenyl-alaninamide-d5
N-Boc-N-methoxy-N-methyl-L-phenyl-alaninamide-d₅ is the deuterium labeled Picoxystrobin. Picoxystrobin is a primary strobilurin fungicide that is widely applied for plant disease control. Picoxystrobin inhibits mitochondrial respiration via blocking elect

HY-P0265AS

β-Amyloid-15N (1-40) TFA
β-Amyloid- ¹⁵N (1-40) (TFA) is the ¹⁵N-labledβ-Amyloid (1-40) (TFA). β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease[1].

HY-116374S

Glycolithocholic acid-d4
Glycolithocholic acid-d₄ is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1][2][3][4].

HY-N6637S

Senecionine N-oxide-d3
Senecionine N-oxide-d₃ is the deuterium labeled Senecionine N-oxide. Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity[1][2].

HY-118645S

1'-Hydroxymidazolam-d4
1'-Hydroxymidazolam-d₄ is the deuterium labeled 1'-Hydroxymidazolam. 1'-Hydroxymidazolam is a primary active metabolite of Midazolam, and it is a neuronal depressant agent. 1'-Hydroxymidazolam could inhibit neuronal activity add to the effects of Midazolam[1][2].

HY-121385S

Hydroxy Bosentan-d6
Hydroxy Bosentan-d₆ is deuterium labeled Hydroxy bosentan. Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities[1].

HY-121385S1

Hydroxy Bosentan-d4
Hydroxy Bosentan-d₄ is deuterium labeled Hydroxy bosentan. Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities[1].

HY-W032022S

1-Hexanol-d13
1-Hexanol-d₁₃ is the deuterium labeled 1-Hexanol[1]. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties[2]. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism[3].

HY-W032022S3

1-Hexanol-d5
1-Hexanol-d₅ is the deuterium labeled 1-Hexanol[1]. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties[2]. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism[3].

HY-W032022S1

1-Hexanol-d11
1-Hexanol-d₁₁ is the deuterium labeled 1-Hexanol[1]. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties[2]. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism[3].

HY-W032022S2

1-Hexanol-d3
1-Hexanol-d₃ is the deuterium labeled 1-Hexanol[1]. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties[2]. 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism[3].

HY-70002AS

N-desmethyl Enzalutamide-d6

N-desmethyl Enzalutamide-d₆ is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].

HY-113313S1

Aldosterone-d7

Aldosterone-d₇ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

HY-W001187S

Tempo-d18
Tempo-d₁₈ is the deuterium labeled Tempo[1]. Tempo is a classic nitroxide radical and is a selective scavenger of ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[2][3][4][5].

HY-109054AS

O-Desmethyltramadol-d6 hydrochloride
O-Desmethyltramadol-d6 (hydrochloride) is a deuterated labeled O-Desmethyltramadol (hydrochloride) . O-Desmethyltramadol (hydrochloride) is a primary active metabolite of Tramadol. O-Demethyltramadol is mainly responsible for its μ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .

HY-132428S

O-Desmethyl Tramadol-d6
O-Desmethyl Tramadol-d₆ is the deuterium labeled O-Desmethyl Tramadol. O-Desmethyl Tramadol is a primary active metabolite of Tramadol. O-Desmethyl Tramadol is mainly responsible for its µ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme[1].

HY-115708S

C22 Phytoceramide-d3 (t18:0/22:0)
C22 Phytoceramide-d3 (t18:0/22:0) is a deuterated labeled C22 Phytoceramide (t18:0/22:0) . C22 Phytoceramide is a sphingolipid that has been found in Moro blood orange (C. sinensis) peels. It has also been found in primary human astrocytes.

HY-N1944S

Nerolidol-d4

Nerolidol-d₄ is deuterated labeled Tenuazonic acid (HY-N6715). Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate . Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D₁ protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor .

HY-109089S

Epeleuton-d5

Epeleuton-d₅ (15(S)-HEPE-d₅ ethyl ester) is deuterium labeled Epeleuton. Epeleuton is a second-generation synthetic N-3 fatty acid derivative with activity in patients with non-alcoholic fatty liver disease, although it did not reach the primary endpoints of alanine aminotransferase and liver stiffness, but it can significantly reduce triglycerides, glycated hemoglobin, plasma glucose and inflammatory markers .

HY-108229S

6β-Naltrexol-d3
6β-Naltrexol-d₃ (6β-Hydroxynaltrexone-d₃) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit .

HY-121636S

Resolvin D2-d5
Resolvin D2-d₅ is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

HY-135581S1

Raloxifene 6-glucuronide-d4 lithium

Raloxifene 6-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[1][2][3].

HY-135582S

Raloxifene 4'-glucuronide-d4

Raloxifene 4'-glucuronide-d₄ is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC₅₀ of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-135582S1

Raloxifene 4'-glucuronide-d4 lithium

Raloxifene 4'-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. [1][2]. Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[3].

HY-125348S

6α-Hydroxy Paclitaxel-d5

6α-Hydroxy Paclitaxel-d₅ is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer .

HY-W653921

Tenuazonic acid-d13

Tenuazonic acid-d₁₃ is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

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Species:	Human (4)
Tag:	His (4) Tag Free (2) Strep (1) GST (1)
Source:	HEK293 (1) E. coli (5)

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