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" in MedChemExpress (MCE) Product Catalog:

386

Inhibitors & Agonists

1

Fluorescent Dye

3

Biochemical Assay Reagents

27

Peptides

13

Inhibitory Antibodies

14

Natural
Products

485

Recombinant Proteins

7

Isotope-Labeled Compounds

130

Antibodies

172

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137584

    1a,1b-Dihomo PGE1

    Prostaglandin Receptor Endocrinology
    1a,1b-Dihomo prostaglandin E1 (1a,1b-Dihomo PGE1) is a class of prostaglandin compound [1].
    1a,1b-Dihomo prostaglandin E1
  • HY-104064
    1A-116
    5 Publications Verification

    Ras Apoptosis Cancer
    1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo [1] .
    1A-116
  • HY-W128112

    alpha-D-Ribofuranoside,2,4(1H,3H)-pyrimidinedione-1

    Nucleoside Antimetabolite/Analog Cancer
    1-(a-D-ribofuranosyl)uracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
    1-(a-D-ribofuranosyl)uracil
  • HY-50202A
    Etomoxir sodium salt
    Maximum Cited Publications
    80 Publications Verification

    (R)-(+)-Etomoxir sodium salt

    Apoptosis Metabolic Disease Cancer
    Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig [1].
    Etomoxir sodium salt
  • HY-131632

    1a,1b-Dihomo-PGF2α

    Endogenous Metabolite Others
    1a,1b-Dihomo prostaglandin F2α (1a,1b-Dihomo-PGF2α) is the derivative of Prostaglandin F2α (HY-12956) [1].
    1a,1b-Dihomo prostaglandin F2α
  • HY-131626

    1a,1b-Dihomo PGE2

    Others Metabolic Disease
    1a,1b-Dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid. 1a,1b-Dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid. This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
    1a,1b-Dihomo prostaglandin E2
  • HY-159675

    Liposome Inflammation/Immunology
    1-A-N is a lipid nanoparticle (LNP) used for in vivo delivery of siRNA. 1-A-N can regulate immune response by delivering siCD45 (siRNA targeting CD45) to T cells and silencing the CD45 gene [1].
    1-A-N
  • HY-P3915

    Bacterial Infection
    Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity [1].
    Esculentin 1A
  • HY-146483

    Amyloid-β Neurological Disease Inflammation/Immunology
    Anti-Aβ agent 1A (compound M15) has potent activity against amyloid-β. Anti-Aβ agent 1A possesses can significantly inhibit LPS-induced levels of IL-1β, IL-6 and TNF-α, and reduces the apoptosis of SH-SY5Y induced by H2O2 through mitochondria pathway. Anti-Aβ agent 1A possesses antioxidant, anti-inflammatory, anti-Aβ toxicity and neuroprotective activities. Anti-Aβ agent 1A can be used for researching Alzheimer’s disease (AD) [1].
    Anti-Aβ agent 1A
  • HY-108790

    Peginterferon β-1a

    Apoptosis Neurological Disease Cancer
    Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon beta-1a can be used for the research of cancer and multiple sclerosis (RMS) [1].
    Peginterferon beta-1a
  • HY-100431A
    IMR-1A
    1 Publications Verification

    Notch Drug Metabolite Cancer
    IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A [1].
    IMR-1A
  • HY-100840

    (S)-4-Carboxy-3-hydroxyphenylglycine

    mGluR Neurological Disease
    (S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice [1].
    (S)-4C3HPG
  • HY-P99138

    Integrin Inflammation/Immunology
    Anti-Mouse IL-1a Antibody is an anti-mouse IL-1a IgG1 antibody inhibitor derived from host Armenian Hamster.
    Anti-Mouse IL-1a Antibody (ALF-161)
  • HY-136267

    HCV Infection
    HCV-IN-30 (compound 48) is a HCV NS5A replication complex inhibitor, with IC50s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively [1].
    HCV-IN-30
  • HY-136972

    (-)-Biflavanone GB-1a

    Others Others
    (-)-GB-1a is a potent antioxidant agent with an IC50 value of 148 µM [1].
    (-)-GB-1a
  • HY-136532
    ZT-1a
    1 Publications Verification

    Others Neurological Disease
    ZT-1a is a potent, non-ATP-competitive and selective SPAK inhibitor. ZT-1a inhibits SPAK activity with IC50s of 44.3, 35.0, 46.7 μM at ATP concentrations of 0.01, 0.1 and 1 mM, respectively [1].
    ZT-1a
  • HY-118335

    SZL 49

    Adrenergic Receptor Neurological Disease
    Prazobind (SZL 49), a prazosin analog, is a potent alpha 1-adrenoceptor blocker. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50=1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes [1] .
    Prazobind
  • HY-50202
    Etomoxir
    Maximum Cited Publications
    80 Publications Verification

    (R)-(+)-Etomoxir

    Apoptosis Metabolic Disease Cancer
    Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
    Etomoxir
  • HY-W420033

    Others Others
    (S)-(+)-Etomoxir is the S enantiomer of Etomoxir (HY-50202). Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig [1].
    (S)-(+)-Etomoxir
  • HY-131994

    STING Infection Cancer
    STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool [1].
    STING agonist-16
  • HY-R02806

    MicroRNA Cancer
    mmu-miR-1a-1-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-1a-1-5p mimic
    mmu-miR-1a-1-5p mimic
  • HY-R02807

    MicroRNA Cancer
    mmu-miR-1a-2-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-1a-2-5p mimic
    mmu-miR-1a-2-5p mimic
  • HY-164220

    Phosphatase Bacterial Infection
    PPM1A-IN-1 (Compound IV-4) is an inhibitor for PP2C Ser/Thr phosphatase protein phosphatase Mg2+/Mn2+-dependent 1A. PPM1A-IN-1 exhibits antibacterial activity against Mycobacterium tuberculosis [1].
    PPM1A-IN-1
  • HY-15522

    Oxytocin Receptor Neurological Disease
    WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder [1].
    WAY-267464
  • HY-157448

    Apoptosis Cancer
    CBR1-IN-6 (compound 1a) is a CBR1 inhibitor with chemosensitizing and cardioprotective activities [1].
    CBR1-IN-6
  • HY-RI02806

    MicroRNA Cancer
    mmu-miR-1a-1-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-1a-1-5p inhibitor
    mmu-miR-1a-1-5p inhibitor
  • HY-RI02807

    MicroRNA Cancer
    mmu-miR-1a-2-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-1a-2-5p inhibitor
    mmu-miR-1a-2-5p inhibitor
  • HY-12294

    NVP-AAM077

    Caspase Apoptosis iGluR Neurological Disease
    PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures [1] .
    PEAQX
  • HY-U00433
    JMV 2959
    2 Publications Verification

    GHSR Neurological Disease Endocrinology
    JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM.
    JMV 2959
  • HY-161978

    CDK Cancer
    CDK4/6-IN-22 (Compound 1-A) is a CDK4 and CDK6 dual inhibitor [1].
    CDK4/6-IN-22
  • HY-149694

    Aurora Kinase Cancer
    Aurora Kinase Inhibitor-12 (Compound 1a ) is the inhibitor of aurora kinase which is a key enzyme that is implicated in tumor growth [1].
    Aurora kinase inhibitor-12
  • HY-129314

    Aldehyde Dehydrogenase (ALDH) Cancer
    CM-39 is a non-covalent and reversible inhibitor for aldehyde dehydrogenase 1A (ALDH1A) with an IC50 of 0.9 μM [1].
    CM-39
  • HY-12782T
    Iadademstat dihydrochloride
    3 Publications Verification

    ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride

    Histone Demethylase Cancer
    Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.
    Iadademstat dihydrochloride
  • HY-115938

    Others Metabolic Disease
    BEC2 is an ester derivative of Baicalin, with good lipid-lowering activity. BEC2 can direct activate the carnitine palmitoyltransferase 1A (CPT1A) [1].
    BEC2
  • HY-147060

    DYRK Neurological Disease
    Dyrk1A-IN-3 (Compound 8b), a highly selective  dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor, maintains high levels of DYRK1A binding affinity (IC50=76 nM). Dyrk1A-IN-3 can be used for the research of neurodegenerative disorders such as Alzheimer’s Disease, Huntington’s Disease, and Parkinson’s Disease [1].
    Dyrk1A-IN-3
  • HY-115995

    Others Cancer
    Antitumor agent-50 (compound 1a), a thiazolidinone, is a potent antitumor agent. Antitumor agent-50 has the potential for osteosarcoma (OS) research [1].
    Antitumor agent-50
  • HY-150074

    Others Cancer
    STING agonist-18 (compound 1a) can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate [1].
    STING agonist-18
  • HY-19880

    Vasopressin Receptor Endocrinology
    RWJ-676070 is a dual vasopressin V(1A)/V(2) receptor antagonist with an Ki value of 1.4 nM and 14 nM respectly [1].
    RWJ-676070
  • HY-112078

    VHL ligand 2; E3 ligase Ligand 1a

    Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein [1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM .
    (S,R,S)-AHPC-Me
  • HY-12294A
    PEAQX tetrasodium hydrate
    5 Publications Verification

    NVP-AAM077 tetrasodium hydrate

    Apoptosis Caspase iGluR Neurological Disease
    PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a tetrasodium hydrate of PEAQX (HY-12294). PEAQX tetrasodium hydrate is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures [1] .
    PEAQX tetrasodium hydrate
  • HY-19612B

    Histone Demethylase Cancer
    DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM.
    DDP-38003 trihydrochloride
  • HY-150074A

    Others Cancer
    STING agonist-18 diTFA (compound 1a) can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate [1].
    STING agonist-18 diTFA
  • HY-12981
    RG7713
    2 Publications Verification

    RO5028442

    Vasopressin Receptor Neurological Disease Endocrinology
    RG7713 (RO5028442) is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).
    RG7713
  • HY-U00433A
    JMV 2959 hydrochloride
    2 Publications Verification

    GHSR Neurological Disease Endocrinology
    JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells.
    JMV 2959 hydrochloride
  • HY-19612A

    Histone Demethylase Cancer
    DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM [1].
    DDP-38003 dihydrochloride
  • HY-D1453

    Biochemical Assay Reagents Cancer
    Immune initiator-1 (Compound 1a) is an amino acid-modified near-infrared Aza-BODIPY photosensitizer, acts as an immune initiator for potent photodynamic research in melanoma [1].
    Immune initiator-1
  • HY-12369

    Others Inflammation/Immunology
    GGTI-2133 is an inhibitor for geranylgeranyltransferase I (GGTase-I) with an IC50 of 38 nM. GGTI-2133 inhibits the geranylation of Rap-1A with an IC50 of 10 μM [1].
    GGTI-2133
  • HY-118932

    HCV Infection
    HCV-IN-45 (Compound EI-1) is an inhibitor for hepatitis C virus (HCV), that inhibits 1a and 1b HCV pseudoparticles with EC50 of 0.134 and 0.027 μM. HCV-IN-45 inhibits 1a/2a and 1b/2a cell culture-adapted HCV (HCVcc), with EC50 of 0.024 and 0.012μM. HCV-IN-45 inhibits the entry of the virus into hepatocyte, and blocks the cell-cell spread [1].
    HCV-IN-45
  • HY-12731

    HCV Infection
    GSK2236805 is a potent hepatitis C virus inhibitor with pEC50 values of 10.4, 11.1 for HCV genotype 1a (gt1a) and gt1b, respectively [1].
    GSK2236805
  • HY-R02806A

    MicroRNA Cancer
    mmu-miR-1a-1-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    mmu-miR-1a-1-5p agomir
    mmu-miR-1a-1-5p agomir

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