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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

proteases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HCV Protease (36) HIV Protease (115) Protease Activated Receptor (PAR) (54) Ser/Thr Protease (69) Virus Protease (57) ADAMTS (1) ADC Linker (2) Amino Acid Derivatives (2) Amyloid-β (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (5) Antibody-Drug Conjugates (ADCs) (5) Apoptosis (53) Atg4 (2) Aurora Kinase (4) Autophagy (21) Bacterial (21) Bcl-2 Family (1) BCRP (1) Beta-lactamase (1) Beta-secretase (2) Biochemical Assay Reagents (15) Bradykinin Receptor (3) c-Myc (2) Calcium Channel (1) Carbonic Anhydrase (1) Carboxypeptidase (1) Caspase (7) Cathepsin (38) CCR (2) CDK (3) Ceramidase (2) ClpP (11) Complement System (3) COX (1) Cytochrome P450 (10) Dengue virus (9) Deubiquitinase (29) Dipeptidyl Peptidase (3) DNA Methyltransferase (2) DNA Stain (1) DNA/RNA Synthesis (11) Drug Metabolite (3) Drug-Linker Conjugates for ADC (2) E1/E2/E3 Enzyme (5) EBV (3) Elastase (7) Endogenous Metabolite (24) Enterovirus (3) Epigenetic Reader Domain (2) ERK (2) FAAH (2) Factor VIIa (1) Factor Xa (13) FAP (1) Fatty Acid Synthase (FASN) (2) Ferroptosis (2) Filovirus (2) Flavivirus (14) Fluorescent Dye (36) Free Fatty Acid Receptor (1) Fungal (2) Furin (2) Glucocorticoid Receptor (2) Glucosidase (1) Glutathione Peroxidase (2) HCV (25) HIF/HIF Prolyl-Hydroxylase (1) HIV (76) HMG-CoA Reductase (HMGCR) (1) HPV (1) HSP (1) HSV (7) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (4) Influenza Virus (2) Interleukin Related (1) Isotope-Labeled Compounds (24) JAK (3) Kallikrein (1) Kisspeptin Receptor (2) Legumain (1) mAChR (4) MALT1 (18) MARCKS (1) MDM-2/p53 (3) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) MMP (5) Necroptosis (2) NF-κB (4) Nucleoside Antimetabolite/Analog (2) P-glycoprotein (7) P2Y Receptor (1) PAI-1 (9) Parasite (19) PCSK9 (1) PDK-1 (1) Phosphatase (2) Phospholipase (2) PI3K (2) PIKfyve (1) PKC (2) Potassium Channel (1) Procollagen C Proteinase (1) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (1) PROTACs (7) Proteasome (14) Pyroptosis (1) Radionuclide-Drug Conjugates (RDCs) (1) Ras (1) Renin (4) Reverse Transcriptase (2) SARS-CoV (179) Separase (1) Sirtuin (1) Small Interfering RNA (siRNA) (2) Thrombin (10) TNF Receptor (3) Topoisomerase (4) TRP Channel (1) Wnt (1) γ-secretase (2)
By Research Areas:	Cancer (194) Cardiovascular Disease (59) Endocrinology (6) Infection (408) Inflammation/Immunology (135) Metabolic Disease (37) Neurological Disease (32)
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798

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

158

Peptides

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Inhibitory Antibodies

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Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Ser/Thr Protease HCV Protease HIV Protease Virus Protease Protease Activated Receptor (PAR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3949

Fluorescent Substrate for Glu-Specific Proteases	Fluorescent Dye	Others
Fluorescent Substrate for Glu-Specific Proteases is a V8 protease-Specific chromogenic substrate .

HY-P0018

Pepstatin 30+ Cited Publications Pepstatin A	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease .

HY-P0018A

Pepstatin Trifluoroacetate 30+ Cited Publications Pepstatin A Trifluoroacetate	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Trifluoroacetate also inhibits HIV protease .

HY-P0018B

Pepstatin Ammonium 30+ Cited Publications Pepstatin A Ammonium	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease .

HY-18234A

Leupeptin hemisulfate 35+ Cited Publications	Cathepsin Ser/Thr Protease Virus Protease	Infection Inflammation/Immunology
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-P3948

Fluorescent Substrate for Pro-Specific Proteases	Fluorescent Dye	Others
Fluorescent Substrate for Pro-Specific Proteases is a fluorescent substrate of pro-specific proteases. Fluorescent Substrate for Pro-Specific Proteases can be used to detect the hydrolysis rate and activity of target enzyme .

HY-P3950

Fluorescent Substrate for Asp-Specific Proteases	Fluorescent Dye	Others
Fluorescent Substrate for Asp-Specific Proteases is a substrate to cleave specifically the Asp-Val bond .

HY-P0018C

Pepstatin acetate Pepstatin A acetate	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) acetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin acetate also inhibits HIV protease .

HY-153921

DEPN-8	Dengue virus	Infection
DEPN-8 is a WNV protease substrate. DEPN-8 is used for dengue virus protease inhibitor development .

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-E70200

Recombinant Kex2 protease	Ser/Thr Protease	Others
Recombinant Kex2 protease is a membrane-bound, Ca ²⁺-dependent serine protease. Recombinant Kex2 protease specifically recognize and cleave the carboxyl-terminal peptide bonds of dibasic amino acids .

HY-P2502

*Hepatitis Virus C NS3 Protease* Inhibitor 2**	HCV Protease HCV	Infection
Hepatitis Virus C NS3 Protease Inhibitor 2 is a product-based peptide inhibitor of hepatitis C virus (HCV) NS3 protease, with a K_i of 41 nM .

HY-126973

BI-1230	HCV Protease	Infection
BI-1230 is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity .

HY-P4018

*HIV Protease* Substrate IV**	HIV Protease	Infection
HIV Protease Substrate IV is a substrate of HIV protease. HIV Protease Substrate IV can be used to measure the activity of HIV (human immunodeficiency virus) -1 protease .

HY-125148

AQ148	HIV Protease	Infection
AQ148 is a HIV-1 protease inhibitor (K_i=137 nM). The IC₅₀ values ??of AQ148 for the inhibition of HIV-1, HIV-2 and SIV aspartic proteases are 1.5 μM, 3.4 μM and 5 μM, respectively .

HY-P2344

*HIV Protease* Substrate 1**	HIV Protease	Infection
HIV Protease Substrate 1, a fiuorogenic HIV protease substrate, can be used to study enzymatic activity of HIV protease .

HY-118057

L-739594	HIV	Inflammation/Immunology
L-739594 is a HIV-1 protease inhibitor, with an IC₅₀ of 1.8 nM .

HY-P2344A

*HIV Protease* Substrate 1 TFA**	HIV Protease	Infection
HIV Protease Substrate 1 TFA, a fiuorogenic HIV protease substrate, can be used to study enzymatic activity of HIV protease .

HY-125551

L-687908	HIV Protease	Infection
L-687908 is a HIV-1 protease inhibitor (CIC₉₅: 12 nM) .

HY-155691

*HIV-1 protease-IN-12*	HIV Protease	Infection
HIV-1 protease-IN-12 (compound 35b) is a HIV-1 protease inhibitor with an IC₅₀ of 0.51 nM. HIV-1 protease-IN-12 also inhibits drug-resistant variant .

HY-108285

(Rac)-Telmesteine	Ser/Thr Protease Others	Inflammation/Immunology
(Rac)-Telmesteine is a *protease* inhibitor and is thus a suitable enzyme stabilizer extracted from patent WO 2017220302 A1, compound II-1. (Rac)-Telmesteine can be used as an enzyme stabilizer in protease-containing detergents and cleaning agents .

HY-155690

*HIV-1 protease-IN-11*	HIV Protease	Infection
HIV-1 protease-IN-11 (compound 34a) is a HIV-1 protease inhibitor with an IC₅₀ of 0.41 nM. HIV-1 protease-IN-11 also exhibits significant activity against drug-resistant variant .

HY-146804

*HIV-1 protease-IN-3*	HIV HIV Protease	Infection
HIV-1 protease-IN-3 (compound 14) is a potent inhibitor of HIV-1 protease (IC₅₀=71 nM; EC₅₀=0.86 μM) .

HY-121514

Talopeptin	Others	Others
Talopeptin is a metal protease inhibitor that can be produced by the streptomyces MK-23 .

HY-144688

*HIV-1 protease-IN-1*	HIV	Infection
HIV-1 protease-IN-1 (Compound 1e) is a potent inhibitor of HIV-1 protease with an IC₅₀ of 90 pM. HIV-1 protease-IN-1 demonstrates antiviral activity with EC₅₀ value of 89 nM against B-HIV. HIV-1 protease-IN-1 exhibits activity with EC₅₀ value of 13.59 nM against C-HIV strain ZM246. HIV-1 protease-IN-1 shows remarkable activity with EC₅₀ value of 8.23 nM against C-HIV strain Indie ^[1].

HY-147650

*HIV-1 protease-IN-5*	HIV Protease	Infection
HIV-1 protease-IN-5 (Compound 13c) is a HIV-1 protease inhibitor with an IC₅₀ of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants .

HY-144742

NS2B/NS3-IN-6	Virus Protease	Infection
NS2B/NS3-IN-6 (Compound 1a) is an allosteric DENV and ZIKV NS2B/NS3 protease inhibitor with IC₅₀ values of 2.23 µM and 25.2 µM against ZIKV and DENV proteases, respectively .

HY-P2942

Chymotrypsinogen	Ser/Thr Protease	Inflammation/Immunology
Chymotrypsinogen is an inactive precursor of Chymotrypsin (HY-108910). Chymotrypsin is a serine protease produced by the pancreas .

HY-N7672

Isoeuphorbetin	HCV Protease	Infection
Isoeuphorbetin, a dimeric coumarin isolated from Viola philippica, is a potent HCV protease inhibitor with an IC₅₀ of 3.63 µg/mL .

HY-I0179

ITMN 4077	HCV Protease	Infection
ITMN 4077 is a macrocyclic inhibitor against Hepatitis C Virus (HCV) NS3 protease (EC₅₀: 2131 nM) .

HY-120712

Ro 31-8588	HIV Protease	Infection
Ro 31-8588 is a HIV protease inhibitor with the K_i of 0.3 nM. Ro 31-8588 can be used for study of AIDS .

HY-157804

PROTAC SARS-CoV-2 Mpro degrader-1	PROTACs SARS-CoV	Infection
PROTAC SARS-CoV-2 Mpro degrader-1 (compound 5) is a PROTAC degrader targeting the major SARS-CoV-2 protease with broad-spectrum antiviral activity .

HY-P4243

Dansyl-Glu-Gly-Arg-Chloromethylketone	Ser/Thr Protease	Others
Dansyl-Glu-Gly-Arg-Chloromethylketone is a *protease* inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone inhibits activated porcine factor IX .

HY-W129596

Policresulen	Virus Protease	Infection
Policresulen is a potent inhibitor of DENV2 NS2B/NS3 protease (IC₅₀ of 0.48 μg/mL). Policresulen inhibits DENV2 replication in BHK-21 cells with IC₅₀ of 4.99 μg/mL. Policresulen acts as a competitive inhibitor of the protease, and slightly affects the protease stability .

HY-120673

SQ 32970	Renin	Cardiovascular Disease
SQ 32970 is a tripeptidic renin inhibitor. SQ 32970 potently inhibits endothia protease .

HY-106188

L 756423	HIV Protease	Infection
L 756423 is a potent HIV protease inhibitor. L 756423 has the potential for the research of HIV infection .

HY-144736

NS2B/NS3-IN-4	Virus Protease	Infection
NS2B/NS3-IN-4 (Compound 34e) is an allosteric DENV2 and ZIKV NS2B/NS3 protease inhibitor with IC₅₀ values of 0.69 µM and 1.04 µM against DENV2 and ZIKV NS2B/NS3 proteases, respectively .

HY-144740

NS2B/NS3-IN-5	Virus Protease	Infection
NS2B/NS3-IN-5 (Compound 25b) is an allosteric DENV2 and ZIKV NS2B/NS3 protease inhibitor with IC₅₀ values of 0.67 µM and 4.38 µM against ZIKV and DENV2 NS2B/NS3 proteases, respectively .

HY-P4466

Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2	HIV Protease	Infection
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of HIV-1 protease. Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 can be used to test HIV-1 protease activity .

HY-146012

*HIV-1 protease-IN-4*	HIV	Infection
HIV-1 protease-IN-4 (Compound II-22) is a potent HIV-1 protease inhibitor. HIV-1 protease-IN-4 is a proagent of atazanavir. HIV-1 protease-IN-4 as a proagent that delivers the parent 1 to rat plasma with a 5-fold higher AUC and 67-fold higher C24 when compared to oral administration of the parent agent .

HY-108904

Urokinase, Human urine Urokinase-type plasminogen activator; Uronase; Win 22005; Win-Kinase	Ser/Thr Protease	Cardiovascular Disease Cancer
Urokinase (peptidolytic) (EC 3.4.21.73) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in turn participates in thrombolysis or extracellular matrix degradation, implicated in vascular disease and cancer-related research .

HY-153076

Flaviviruses-IN-3	Virus Protease	Infection
Flaviviruses-IN-3 (compound 87) is a potent flaviviruse inhibitor. Flaviviruses-IN-3 reduces the WNV (West Nile virus) protease activity, with a inhibition of 54% .

HY-143470

SARS-CoV-2-IN-18	SARS-CoV	Infection
SARS-CoV-2-IN-18 (Compound 26) is a potent SARS-CoV-2 3C-like protease inhibitor with an IC₅₀ of 45 nM .

HY-P3208

Endoproteinase Lys-C	Others	Others
Endoproteinase Lys-C is a protease that cleaves proteins on the C-terminal side of lysine residues and is commonly used for protein sequencing .

HY-E70392

Recombinant Trypsin	Ser/Thr Protease	Others
Recombinant Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine .

HY-150784

XR8-89	SARS-CoV	Infection
XR8-89 is a potent *papain-like protease* (PL ^pro) inhibitor with an IC₅₀** value of 0.1 μM. XR8-89 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. XR8-89 can be used for SARS-CoV-2 research .

HY-150786

PLP_Snyder530	SARS-CoV	Infection
PLP_Snyder530 is a potent *papain-like protease* (PL ^pro) inhibitor with an IC₅₀** value of 6.4 μM. PLP_Snyder530 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. PLP_Snyder530 can be used for SARS-CoV-2 research .

HY-P3208A

Endoproteinase Lys-C (Tag-free)	Others	Others
Endoproteinase Lys-C (Tag-free) is a protease that cleaves proteins on the C-terminal side of lysine residues and is commonly used for protein sequencing .

HY-150789

SARS-CoV-2-IN-23	SARS-CoV	Infection
SARS-CoV-2-IN-23 (compound GRL-0617) is a SARS-COV-2 papain-like protease (PLpro) inhibitor with an IC₅₀ value of 2.3 μM .

HY-150783

SARS-CoV-2-IN-24	SARS-CoV	Infection
SARS-CoV-2-IN-24 (compound 7) is a potent *papain-like protease* (PL ^pro)** inhibitor. SARS-CoV-2-IN-24 induces conformational changes in SARS-COV-2 papain-like protease, inhibiting SARS-CoV-2 replication. SARS-CoV-2-IN-24 can be used for SARS-CoV-2 research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P0018

Pepstatin 30+ Cited Publications Pepstatin A	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	HIV Protease Autophagy
Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease .

HY-P0018A

Pepstatin Trifluoroacetate 30+ Cited Publications Pepstatin A Trifluoroacetate	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	HIV Protease Autophagy
Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Trifluoroacetate also inhibits HIV protease .

HY-P0018B

Pepstatin Ammonium 30+ Cited Publications Pepstatin A Ammonium	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	HIV Protease Autophagy
Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease .

HY-18234A

Leupeptin hemisulfate Maximum Cited Publications 37 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Cathepsin Ser/Thr Protease Virus Protease
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-N9528

Lyciumin A	Cardiovascular Disease Alkaloids Monophenols Pyrrole Alkaloids Classification of Application Fields Source classification Phenols Plants Solanaceae Lycium chinense Miller Disease Research Fields Indole Alkaloids	Angiotensin-converting Enzyme (ACE) Renin
Lyciumin A, a cyclic octapeptide, exhibits inhibitory activity on proteases, renin and angiotensin-converting enzyme. Lyciumin A can be used for the research of hypertension .

HY-N10420

Hinokinin 1 Publications Verification (-)-Hinokinin	Infection Acanthaceae Classification of Application Fields Source classification Lignans Phenylpropanoids Hypoestes aristata (Vahl) Sol. ex Roem. & Schult. Plants Disease Research Fields	HIV Protease
Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .

HY-126085

(±)-Alliin 2 Publications Verification (±)-L-Alliin	Infection Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields A．Sativam L. var．Viviparum Regel	SARS-CoV
(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (M_pro) .

HY-N9366

Tumulosic acid 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Source classification Poria cocos Plants Inflammation/Immunology Disease Research Fields	Others
Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC₅₀= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM .

HY-N7672

Isoeuphorbetin	Infection Classification of Application Fields Gramineae Source classification Coumarins Phenols Polyphenols Leptochloa chinensis (Linn.) Nees Phenylpropanoids Plants Disease Research Fields	HCV Protease
Isoeuphorbetin, a dimeric coumarin isolated from Viola philippica, is a potent HCV protease inhibitor with an IC₅₀ of 3.63 µg/mL .

HY-N2355

Solasurine	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Solanum surattense Burm. F. Source classification Other Diseases Plants Solanaceae Disease Research Fields	SARS-CoV
Solasurine is a steroidal alkaloid that can be isolated from Solanum surrattence. Solasurine can interact with the C3-like protease (SARS-CoV-2 main protease) amino acids Phe8, Pro9, Ile152, Tyr154, Pro293, Phe294, Val297, and Arg298 .

HY-N4332

Rivulariapeptolides 1121	Natural Products Microorganisms Source classification	Ser/Thr Protease
Rivulariapeptolides 1121 is a high potent and selective serine protease inhibitor with IC₅₀ values of 35.52 nM, 13.24 nM and 48.05 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-N10420R

Hinokinin (Standard)	Acanthaceae Source classification Lignans Phenylpropanoids Hypoestes aristata (Vahl) Sol. ex Roem. & Schult. Plants	HIV Protease
Hinokinin (Standard) is the analytical standard of Hinokinin. This product is intended for research and analytical applications. Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme .

HY-N2360

Hinokiflavone 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	E1/E2/E3 Enzyme Apoptosis MMP ClpP
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC₅₀ value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

HY-126085R

(±)-Alliin (Standard)	Structural Classification Liliaceae Ketones, Aldehydes, Acids Source classification Plants A．Sativam L. var．Viviparum Regel	SARS-CoV
(±)-Alliin (Standard) is the analytical standard of (±)-Alliin. This product is intended for research and analytical applications. (±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (Mpro) .

HY-N4331

Rivulariapeptolides 1185	Natural Products Microorganisms Source classification	Ser/Thr Protease
Rivulariapeptolides 1185 is a high potent and selective serine protease inhibitor with IC₅₀ values of 13.17 nM, 23.59 nM and 55.26 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-N4333

Rivulariapeptolides 988	Natural Products Microorganisms Source classification	Ser/Thr Protease
Rivulariapeptolides 988 is a high potent and selective serine protease inhibitor with IC₅₀ values of 95.46 nM, 15.29 nM and 85.50 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-N15154

Tasiamide B	Structural Classification Natural Products Marine algae Marine natural products Source classification	Cathepsin HSP
Tasiamide B is a Cathepsin D inhibitor, which is a linear peptide isolated from the marine cyanobacteria Symploca sp.. Tasiamide B is proved as a good template for the development of aspartic proteases inhibitors. Tasiamide B is effective against skin cancer by strongly interacting with the target protein HSP90 .

HY-N11940

Acetyl-binankadsurin A	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Kadsura longipedunculata Finet et Gagnep.	HIV Protease
Acetyl-binankadsurin A (compound 5) is a lignan isolated from Kadsura longipedunculata. Acetyl-binankadsurin A has low inhibitory activity against HIV-1 protease, with IC₅₀ >100 μg/mL .

HY-N8471

Niazinin	Structural Classification Natural Products Classification of Application Fields Moringa oleifera Lam. Source classification Moringaceae Plants Inflammation/Immunology Disease Research Fields	Parasite SARS-CoV
Niazinin is a thiocarbamate glycoside with antileishmanial activities, with an IC₅₀ value of 5.25 μM. Niazinin also shows a binding affinity with the target protein 3CL protease. Niazinin has promising leishmanicidal, anti-inflammatory and anti-pyretic activity .

HY-N12129

6,6′-Dihydroxythiobinupharidine	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Plants Nuphar pumila (Timm) de Candolle Nymphaeaceae	Cathepsin
6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively .

HY-N2565

Rosamultin	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Rosaceae Potentilla anserina Linn. Plants Disease Research Fields	HIV Protease Apoptosis
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina?L. Rosamultin has inhibitory effects against HIV-1 protease . Rosamultin has the potential for treating H₂O₂-induced oxidative stress injury through its antioxidant and antiapoptosis effects .

HY-N1739

Tectoquinone 2-Methylanthraquinone	Quinones Structural Classification Clausena heptaphylla (Roxb.) Wight & Arn. Anthraquinones Source classification Rutaceae Plants	SARS-CoV Virus Protease
Tectoquinone (2-Methylanthraquinone) is a SARSCoV-2 main protease inhibitor against COVID-19. Tectoquinone exhibits strong mosquito larvicidal activity with the LC₅₀ values of 3.3 and 5.4 μg/ml against A. aegypti and A. albopictus in 24 h, respectively .

HY-N4155

2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid	Rosaceae Rosa cymosa (L.) Tratt. Plants	EBV HIV Protease HSV
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells .

HY-131577

*Neutral protease, Paenibacillus polymyxa* 1 Publications Verification Dispase II, Dispase	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Neutral protease, Paenibacillus polymyxa (Dispase II, Dispase) is a neutral protease and potent fibronectinase and type IV collagenase. Neutral protease, Paenibacillus polymyxa can be used to separate the intact epidermis from the dermis and intact epithelial sheets in culture from the substratum .

HY-N12716

Longipedunin A	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura longipedunculata Finet et Gagnep. Schisandraceae	HIV Protease
Longipedunin A is a HIV-1 Protease inhibitor with an IC₅₀ value of 50 µg/mL .

HY-N2786

8-Prenylluteone	Structural Classification Flavonoids Erythrinasenegalensis DC. Leguminosae Source classification Plants Isoflavones	HIV Protease
8-Prenylluteone is a HIV-1 protease inhibitor, with an IC₅₀ of 4 μM .

HY-126034

3,4-Dichloroisocoumarin	Structural Classification Animals Source classification Coumarins Phenylpropanoids	Ser/Thr Protease
3,4-Dichloroisocoumarin is a potent *serine-protease* inhibitor that inhibits chymotrypsin-like activity .

HY-P1645

Papain 5+ Cited Publications	Carica papaya L. Structural Classification Natural Products Classification of Application Fields Source classification Caricaceae Plants Inflammation/Immunology Disease Research Fields	Cathepsin
Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries.

HY-N5068

Isorhamnetin 7-O-α-L-rhamnoside	Infection Flavonols Structural Classification Flavonoids Classification of Application Fields Elaeagnaceae Source classification Phenols Polyphenols Hippophae rhamnoides subsp. sinensis Rousi Plants Disease Research Fields	SARS-CoV
Isorhamnetin 7-O-α-L-rhamnoside shows binding affinity with COVID-19 virus main protease .

HY-17431

Fosamprenavir Calcium Salt 4 Publications Verification GW433908G	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	HIV Endogenous Metabolite
Fosamprenavir Calcium Salt (GW433908G) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility . Anti-HIV infection .

HY-78726

Fosamprenavir 4 Publications Verification Amprenavir phosphate; GW 433908	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	HIV Endogenous Metabolite
Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility . Anti-HIV infection .

HY-17367

Atazanavir 10+ Cited Publications BMS-232632	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM .

HY-17367A

Atazanavir sulfate 10+ Cited Publications BMS-232632 sulfate	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir sulfate is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM .

HY-N0556

Isoescin IA	Other Terpenoids Infection Aesculus chinensis Bunge Classification of Application Fields Terpenoids Hippocastanaceae Source classification Plants Disease Research Fields	HIV Protease
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N8205

Hispidulin 4'-O-β-D-glucopyranoside	Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	SARS-CoV
Hispidulin 4'-O-β-D-glucopyranosid, a natural compound, may serve as a potential COVID-19 main protease inhibitor .

HY-N10934

Ganoderic acid GS-1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	HIV Protease
Ganoderic acid GS-1, a highly oxygenated lanostane-type triterpenoid, has anti-HIV-1 protease activities with an IC₅₀ of 58 μM .

HY-N4330

Rivulariapeptolides 1155	Natural Products Microorganisms Source classification	Ser/Thr Protease
Rivulariapeptolides 1155 is a potent serine protease inhibitor with IC₅₀s of 41.84, 4.94, 56.54 nM for chymotrypsin, elastase, prpteinase K, respectively .

HY-N8520

Variculanol	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Bacterial
Variculanol is an antimicrobial, anticancer and anti-HCV NS3/4A Protease agent which can be extracted from marine fungus Aspergillus versicolor .

HY-17367R

Atazanavir (Standard)	Structural Classification Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (Standard) is the analytical standard of Atazanavir. This product is intended for research and analytical applications. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 3.49 μM .

HY-17367AR

Atazanavir sulfate (Standard)	Structural Classification Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
Atazanavir (sulfate) (Standard) is the analytical standard of Atazanavir (sulfate). This product is intended for research and analytical applications. Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 3.49 μM .

HY-N3502

20(21)-Dehydrolucidenic acid A	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields	HIV Protease
20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity .

HY-N10076

Ganomycin I	Structural Classification Microorganisms Source classification Phenols Polyphenols	HMG-CoA Reductase (HMGCR) Glucosidase HIV Protease
Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects .

HY-18234C

Leupeptin Ac-LL hydrochloride	Structural Classification Natural Products Microorganisms Source classification	Biochemical Assay Reagents
Leupeptin Ac-LL (hydrochloride) is the hydrochloride form of Leupeptin Ac-LL (HY-18234B). Leupeptin Ac-LL (hydrochloride) has better inhibition than Leupeptin Ac-LL .

HY-N1910

4'-O-Methylbavachalcone 1 Publications Verification	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields	SARS-CoV
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM .

HY-100397

Elastatinal	Microorganisms Source classification	Elastase
Elastatinal is a potent and competitive inhibitor of elastase, with a K_i of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease .

HY-17431R

Fosamprenavir Calcium Salt (Standard) GW433908G (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	HIV Endogenous Metabolite
Fosamprenavir (Calcium Salt) (Standard) is the analytical standard of Fosamprenavir (Calcium Salt). This product is intended for research and analytical applications. Fosamprenavir Calcium Salt (GW433908G) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility . Anti-HIV infection .

HY-N1992

Theaflavin 3,3'-digallate 5 Publications Verification TF-3; ZP10	Infection Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae	Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (K_d=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N0556R

Isoescin IA (Standard)	Other Terpenoids Aesculus chinensis Bunge Structural Classification Terpenoids Hippocastanaceae Source classification Plants	HIV Protease
Isoescin IA (Standard) is the analytical standard of Isoescin IA. This product is intended for research and analytical applications. Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-P1998

Pepsinostreptin	Structural Classification Natural Products Microorganisms Source classification	Others
Pepsinostreptin is an enzyme inhibitor with the activity of inhibiting pepsin. Pepsinostreptin can form a 1:1 complex with pepsin and significantly inhibit its activity. The activity of pepsinostreptin makes it have important application potential in the study of protease inhibition and related biological processes .

HY-116700

Hinnuliquinone	Structural Classification Natural Products Nepenthes mirabilis (Lour.) Druce Source classification Plants Nepenthaceae	HIV Protease HIV
Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum .

Cat. No.	Product Name	Chemical Structure

HY-15287S1

Nelfinavir-d4
Nelfinavir-d₄ is deuterated labeled Nelfinavir (HY-15287). Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (K_i=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .

HY-17367S

Atazanavir-d15
Atazanavir-d15 is the d₁₅ labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .

HY-17367S1

Atazanavir-d18
Atazanavir-d18 is the d₁₈ labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .

HY-15148S1

Tipranavir-d7
Tipranavir-d₇ is deuterated labeled Tipranavir (HY-15148). Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC₅₀s of 66-410 nM . Tipranavir inhibits SARS-CoV-2 3CL ^pro activity .

HY-17367S3

Atazanavir-d5
Atazanavir-d₅ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S2

Atazanavir-d9
Atazanavir-d₉ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-10235S

Telaprevir-d4
Telaprevir-d₄ is the deuterium labeled Telaprevir. Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide[1][2][3]. Telaprevir inhibits SARS-CoV-2 3CLpro activity[4].

HY-B0689S

Indinavir-d6
Indinavir-d₆ is the deuterium labeled Indinavir. Indinavir (MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.

HY-14588S2

Lopinavir-d7

Lopinavir-d₇ is deuterated labeled Lopinavir (HY-14588). Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM .

HY-14588S1

Lopinavir-d8
Lopinavir-d₈ (ABT-378-d8) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[1][2]. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM[3].

HY-78726S

Fosamprenavir-d4
Fosamprenavir-d₄ is deuterium labeled Fosamprenavir. Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility[1]. Anti-HIV infection[1].

HY-10241S

Simeprevir-13C,d3

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].

HY-14588S

(rel)-Lopinavir-d8

(rel)-Lopinavir-d₈ ((rel)-ABT-378-d₈)is the deuterium labeledLopinavir(HY-14588) . Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM .

HY-17007S

Saquinavir-d9
Saquinavir-d₉ is the deuterium labeled Saquinavir. Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.36 μM[1][2].

HY-90001S

Ritonavir-d6
Ritonavir-d₆ is the deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM[1][2].

HY-90001S2

Ritonavir-d8
Ritonavir-d₈ is deuterated labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.61 μM.

HY-90001S1

Ritonavir-13C,d3
Ritonavir- ¹³C,d₃ is the ¹³C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.

HY-17430S1

Amprenavir-d4-1
Amprenavir-d₄-1 is deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.

HY-17430S

Amprenavir-d4
Amprenavir-d₄ is the deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM[1][2].

HY-D0843S

N-Ethylmaleimide-d5
N-Ethylmaleimide-d₅ is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3].

HY-B0190S1

Nafamostat formate salt-13C6
Nafamostat formate salt- ¹³C₆ is the ¹³C labeled Nafamostat. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2 .

HY-15287S

Nelfinavir-d3
Nelfinavir-d₃ (AG1341-d3) is the deuterium labeled Nelfinavir. Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent[1][2][3].

HY-B0372AS

Bromhexine-d3 hydrochloride

Bromhexine-d₃ (hydrochloride) is deuterium labeled Bromhexine (hydrochloride). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions[1][2][3][4].

HY-90001S3

rel-Ritonavir-d6
rel-Ritonavir-d₆ (rel-ABT 538-d₆; rel-RTV-d₆) is the deuterium labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 1.61 μM .

HY-10237S

Boceprevir-d9
Boceprevir-d₉ is the deuterium labeled Boceprevir. Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay[1][2][3][4][5]. Boceprevir inhibits SARS-CoV-2 3CLpro activity[6].

HY-10119S

Vorapaxar-d5
Vorapaxar-d₅ is deuterated labeled Vorapaxar (HY-10119). Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (K_i=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .

HY-W027544S

(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3
(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d₃ is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3].

HY-106161S1

Rupintrivir-d7
Rupintrivir-d7 is a deuterated labeled Rupintrivir . Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC₅₀ of 0.023 μM. Rupintrivirvr shows immune-modulatory effect .

HY-W027544S1

(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6

(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d₆ is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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