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neurons

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (18) Adenosine Deaminase (2) Adenosine Receptor (3) Adrenergic Receptor (7) Akt (6) Aminopeptidase (1) Amyloid-β (8) Anaplastic lymphoma kinase (ALK) (1) Angiotensin Receptor (2) Antibiotic (1) Apelin Receptor (APJ) (2) Apoptosis (36) ATF6 (1) Atg8/LC3 (2) ATTECs (2) Autophagy (14) Bacterial (8) Bcl-2 Family (4) Bcr-Abl (1) Biochemical Assay Reagents (2) c-Met/HGFR (2) Calcium Channel (24) CaMK (1) Cannabinoid Receptor (1) Caspase (7) CDK (3) CFTR (1) Chloride Channel (2) Cholinesterase (ChE) (4) COX (5) CRFR (1) Cytochrome P450 (3) DAPK (1) Deubiquitinase (3) DNA/RNA Synthesis (9) Dopamine Receptor (10) Drug Metabolite (1) Dynamin (1) E1/E2/E3 Enzyme (2) EGFR (1) Endogenous Metabolite (31) Epigenetic Reader Domain (2) ERK (4) Estrogen Receptor/ERR (4) FAAH (1) FAK (2) Fat Mass and Obesity-associated Protein (FTO) (1) Fluorescent Dye (10) Fungal (3) GABA Receptor (22) Glucocorticoid Receptor (1) Glucosidase (1) Glutathione Peroxidase (1) GPR52 (1) GSK-3 (2) HBV (1) HDAC (4) Histamine Receptor (4) Histone Acetyltransferase (2) Histone Demethylase (2) HSP (4) IGF-1R (2) iGluR (33) Imidazoline Receptor (1) Interleukin Related (3) Isotope-Labeled Compounds (12) JNK (6) Keap1-Nrf2 (1) LRRK2 (2) mAChR (5) MAGL (1) MAP4K (1) Mas-related G-protein-coupled Receptor (MRGPR) (1) MDM-2/p53 (1) MEK (1) mGluR (9) Microtubule/Tubulin (5) Mitochondrial Metabolism (11) Mitophagy (4) Mixed Lineage Kinase (1) MMP (1) Monoamine Oxidase (2) Monoamine Transporter (2) mTOR (2) Na+/Ca2+ Exchanger (1) Na+/H+ Exchanger (NHE) (3) Na+/K+ ATPase (1) nAChR (16) Neurokinin Receptor (5) Neuropeptide Y Receptor (4) NF-κB (1) NO Synthase (6) Notch (1) Opioid Receptor (10) Orexin Receptor (OX Receptor) (2) Oxytocin Receptor (2) P-glycoprotein (2) P2X Receptor (1) p38 MAPK (4) Parasite (12) PARP (4) PDGFR (1) PERK (1) PGE synthase (2) Phosphatase (5) PI3K (2) PINK1/Parkin (3) PKA (5) PKC (3) Potassium Channel (25) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (3) PROTACs (1) Protease Activated Receptor (PAR) (1) Pyroptosis (1) RAR/RXR (2) Reactive Oxygen Species (9) ROCK (1) SARS-CoV (1) Ser/Thr Protease (3) Serotonin Transporter (2) Sigma Receptor (4) Sirtuin (1) Smo (1) Sodium Channel (32) Somatostatin Receptor (1) Src (1) Survivin (2) Tau Protein (4) TGF-β Receptor (1) Thyroid Hormone Receptor (2) TRP Channel (15) VEGFR (1) α-synuclein (7) γ-secretase (3)
By Research Areas:	Cancer (62) Cardiovascular Disease (21) Endocrinology (22) Infection (25) Inflammation/Immunology (50) Metabolic Disease (23) Neurological Disease (429)
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483

Inhibitors & Agonists

Screening Libraries

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1161

True Blue NCI 240899	Fluorescent Dye	Neurological Disease
True Blue (NCI 240899) is a fluorescent dye, as neuronal retrograde tracer (excitation wavelength 395-425 nm, barrier filter 450 nm). True Blue can label neuron and has no effects on neuronal survival .

HY-126112

Mephenoxalone	Others	Neurological Disease
Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc .

HY-D1631

Calcium Green-5N AM	Fluorescent Dye	Neurological Disease
Calcium Green-5N AM is a novel Ca ²⁺-sensitive fluorescent probe. Calcium Green-5N AM shows enhancement in fluorescence intensity on binding Ca ²⁺, and can monitor free Ca ²⁺ in neurons .

HY-B1304A

(+)-Sparteine sulfate pentahydrate 1 Publications Verification (+)-Lupinidine sulfate pentahydrate	nAChR	Neurological Disease
(+)-sparteine (sulfate pentahydrate) is a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons .

HY-139145

Etbicyphat Trimethylopropane phosphate	GABA Receptor	Neurological Disease
Etbicyphat (Trimethylopropane phosphate) is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors .

HY-W008719

MPP+ iodide 10+ Cited Publications	Mitochondrial Metabolism	Neurological Disease
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .

HY-126112R

Mephenoxalone (Standard)	Others	Neurological Disease
Mephenoxalone (Standard) is the analytical standard of Mephenoxalone. This product is intended for research and analytical applications. Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc .

HY-D1638

Biocytin Lucifer Yellow potassium	Fluorescent Dye	Neurological Disease
Biocytin Lucifer Yellow potassium is a water soluble fluorescent dye. Biocytin Lucifer Yellow potassium exhibits strong fluorescence from 450 to 650 nm, and can be used for tracing retinal neurons .

HY-121252

Dopal	Endogenous Metabolite Reactive Oxygen Species α-synuclein	Neurological Disease
Dopal is an aldehyde that can be generated in Parkinson's disease by enzymatic degradation of dopamine. Dopal can generate reactive oxygen species, and triggers aggregation of α-synuclein. DOPAL elicits α-synuclein accumulation and hampers α-synuclein clearance in primary neurons .

HY-108479

Nolpitantium SR140333	Neurokinin Receptor	Neurological Disease
Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK₁ receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation .

HY-B1176

Equilin 7-Dehydroestrone	Estrogen Receptor/ERR	Endocrinology
Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism .

HY-D2260

hMSCs-Neu perchlorate	Fluorescent Dye	Neurological Disease
hMSCs-Neu perchlorate (Compound 4) is a fluorescent probe that converts hMSCs into neurons in the presence of fibroblast growth factor (FGF). hMSCs-Neu perchlorate may have important applications in neuropathology and neurodegeneration research .

HY-123506

Fenlean	Src	Neurological Disease Inflammation/Immunology
Fenlean, a natural squamosamide derivative, is a Src tyrosine kinase inhibitor. Fenlean can inhibit over-activated microglia and protect dopaminergic neurons. Fenlean can attenuate neuroinflammation in Parkinson's disease models .

HY-100797

(RS)-CPP (±)-CPP	iGluR	Neurological Disease
(RS)-CPP ((±)-CPP) is a potent and selective NMDA antagonist. (RS)-CPP inhibits central neuron responses, and has anticonvulsant activity .

HY-120308

(R)-Nolpitantium SR140603	Neurokinin Receptor	Neurological Disease
(R)-Nolpitantium is the R-enantiomer of Nolpitantium (HY-108479). Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK₁ receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation .

HY-100783

(-)-Bicuculline methobromide 20+ Cited Publications l-Bicuculline methobromide	GABA Receptor	Neurological Disease
(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABA_A receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca ²⁺-activated K ⁺ channels in various types of neurons .

HY-100783A

(-)-Bicuculline methochloride l-Bicuculline methochloride	GABA Receptor	Neurological Disease
(-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABA_A receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca ²⁺-activated K ⁺ channels in various types of neurons .

HY-114690

PNU-140975 BVT.3531	Potassium Channel	Neurological Disease
PNU-140975 (BVT.3531) is a novel and potent bioactive compound. PNU-140975 can reduce body weight and activates K_ATP channel in isolated arcuate neurons in rats .

HY-100355

C18-Ceramide	Endogenous Metabolite	Neurological Disease Cancer
C18-Ceramide can promote exocytosis of glutamate from damaged neurons. C18-Ceramide promotes cell death in glioma cells. Ceramides is involved in diverse cellular functions, such as differentiation, cell cycle progression, cell-cell adhesion, senescence, and apoptosis .

HY-P1387

β-Amyloid (1-40) (rat) 1 Publications Verification	Amyloid-β Apoptosis	Neurological Disease
β-Amyloid (1-40) (rat) is a rat form of the amyloid β-peptide, which accumulates as an insoluble extracellular deposit around neurons, giving rise to the senile plaques associated with Alzheimer's disease (AD). β-Amyloid (1-40) (rat) increases ⁴⁵Ca ²⁺ influx, induces neurodegeneration in the rat hippocampal neurons of the CA1 subfield. β-Amyloid (1-40) (rat) induces apoptosis. β-Amyloid (1-40) (rat) can be used for the research of Alzheimer's disease .

HY-155017

6-Iodoamiloride	Sodium Channel	Neurological Disease Cancer
6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC₅₀ of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC₅₀ of 230 nM .

HY-137103

BTC-AM	Fluorescent Dye	Others
BTC-AM is a low affinity calcium indicator. BTC-AM has substantial calcium-independent fluorescence at all excitation wavelengths. BTC-AM is readily loaded into neurons and is rapidly hydrolysed .

HY-P1293

Conantokin G	iGluR	Neurological Disease
Conantokin G, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G inhibits NMDA-evoked currents in murine cortical neurons with an IC₅₀ of 480 nM. Conantokin G has neuroprotective properties .

HY-123059

(Rac)-ICI-118551 hydrochloride	Adrenergic Receptor	Neurological Disease
(Rac)-ICI-118551 hydrochloride is a selective β2-adrenergic receptor antagonist. (Rac)-ICI-118551 hydrochloride can inhibit dendrite ramification of hippocampal neurons in a mouse model of Alzheimer's disease .

HY-P3933

[Tyr8,Nle11] Substance P	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
[Tyr8,Nle11] Substance P is a Substance P (HY-P0201) analog. Substance P is a peptide mainly secreted by neurons and is involved in many biological processes, including nociception and inflammation .

HY-B1176R

Equilin (Standard)	Estrogen Receptor/ERR	Endocrinology
Equilin (Standard) is the analytical standard of Equilin. This product is intended for research and analytical applications. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism .

HY-10232

THIP 1 Publications Verification Gaboxadol	GABA Receptor	Neurological Disease
THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC₅₀ value of 13 µM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect on miniature IPSCs. THIP can be used in studies of sleep disorders .

HY-P1293A

Conantokin G TFA	iGluR	Neurological Disease
Conantokin G TFA, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G TFA inhibits NMDA-evoked currents in murine cortical neurons with an IC₅₀ of 480 nM. Conantokin G TFA has neuroprotective properties .

HY-P1247

Calcineurin autoinhibitory peptide	Phosphatase	Neurological Disease
Calcineurin autoinhibitory peptide is a selective inhibitor of Ca ²⁺/calmodulin-dependent protein phosphatase (calcineurin), with an IC₅₀ of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death .

HY-P2628

Dabcyl-YVADAPV-EDANS	Fluorescent Dye	Others
Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K ⁺ deprivation-induced apoptosis of cerebellar granule neurons .

HY-116431

I-BOP	Prostaglandin Receptor	Cardiovascular Disease Neurological Disease
I-BOP is an agonist for thromboxane A2 receptor (TP) with a K_D of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle . I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons .

HY-P1247A

Calcineurin autoinhibitory peptide TFA	Phosphatase	Neurological Disease
Calcineurin autoinhibitory peptide TFA is a selective inhibitor of Ca ²⁺/calmodulin-dependent protein phosphatase (calcineurin), with an IC₅₀ of ~10 μM. Calcineurin autoinhibitory peptide TFA could protect neurons from excitatory neuronal death .

HY-136341

7,8-Dihydroneopterin	Apoptosis NO Synthase Endogenous Metabolite	Neurological Disease Inflammation/Immunology
7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases .

HY-124061

GB83	Protease Activated Receptor (PAR)	Neurological Disease Inflammation/Immunology
GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons .

HY-P3777

β-Bag cell peptide	Potassium Channel	Neurological Disease
β-Bag cell peptide is a neuroactive peptide. β-Bag cell peptide elevates cyclic AMP levels in the bag cell neurons. β-Bag cell peptide decreases the amplitudes of the voltage-dependent potassium currents .

HY-18663B

CP-465022 hydrochloride	iGluR	Neurological Disease
CP-465022 hydrochloride is a potent, and selective noncompetitive AMPA receptor antagonist with anticonvulsant activity. CP-465022 is against Kainate-induced response with an IC₅₀ of 25 nM in rat cortical neurons. CP-465022 provides a new tool to investigate the role of AMPA receptors in physiological and pathophysiological processes .

HY-18663A

CP-465022 maleate	iGluR	Neurological Disease
CP-465022 Maleate is a potent, and selective noncompetitive AMPA receptor antagonist with anticonvulsant activity. CP-465022 is against Kainate-induced response with an IC₅₀ of 25 nM in rat cortical neurons. CP-465022 provides a new tool to investigate the role of AMPA receptors in physiological and pathophysiological processes .

HY-18663

CP-465022	iGluR	Neurological Disease
CP-465022 is a potent, and selective noncompetitive AMPA receptor antagonist with anticonvulsant activity. CP-465022 is against Kainate-induced response with an IC₅₀ of 25 nM in rat cortical neurons. CP-465022 provides a new tool to investigate the role of AMPA receptors in physiological and pathophysiological processes .

HY-B1740

Pregnenolone acetate	Microtubule/Tubulin	Neurological Disease
Pregnenolone acetate (compound #43), a nonmetabolized Pregnenolone (HY-B0151) analog, can promote neurite extension and induce a change in growth cone morphology in primary cultures of cerebellar granule neurons. Pregnenolone acetate, a neurosteroid, increases microtubule polymerization. Pregnenolone acetate has the potential for neurodevelopmental diseases research .

HY-P3089

Dendrotoxin K	Potassium Channel	Others
Dendrotoxin K is a Kv1.1 channel blocker. Dendrotoxin K determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform .

HY-100800

TACA trans-4-Aminocrotonic acid	GABA Receptor	Neurological Disease
TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABA_A and GABA_C receptors (K_D= 0.6 μM). TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons .

HY-110302

6'-GNTI dihydrochloride	Opioid Receptor	Neurological Disease
6'-GNTI dihydrochloride, a κ-opioid receptor (KOR) agonist, displays bias toward the activation of G protein-mediated signaling over β-arrestin2 recruitment. 6'-GNTI 6'-GNTI dihydrochloride only activates the Akt pathway in striatal neurons .

HY-B1833

Afloqualone HQ-495	GABA Receptor	Neurological Disease
Afloqualone (HQ-495) is a GABAergic agent and has agonist activity at the β subtype of the GABAα receptor. Afloqualone has antivertiginous effects thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site .

HY-P5868

mHuwentoxin-IV	Sodium Channel	Neurological Disease
mHuwentoxin-IV is a naturally modified Huwentoxin-IV (HY-P1220). mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC₅₀ of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages .

HY-P3089A

Dendrotoxin K TFA	Potassium Channel	Others
Dendrotoxin K TFA is a Kv1.1 channel blocker. Dendrotoxin K TFA determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform .

HY-P5277

TAT-GluN2BCTM	DAPK	Neurological Disease
TAT-GluN2BCTM is a membrane-permeable DAPK1-targeting peptide. TAT-GluN2BCTM targets active DAPK1 to lysosomes for degradation. TAT-GluN2BCTM protects neurons from oxidative stress and NMDAR-mediated excitotoxicity by knocking down DAPK1. TAT-GluN2BCTM can be used in the study of neuroprotection .

HY-100834A

5,7-Dichlorokynurenic acid sodium 5,7-DCKA sodium	iGluR	Neurological Disease
5,7-Dichlorokynurenic acid (sodium) is the sodium form of 5,7-Dichlorokynurenic acid (HY-100834). 5,7-Dichlorokynurenic acid is a selective and competitive antagonist of the glycine site on the NMDA receptor with a K_B of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduces NMDA-induced neuron injury in rat cortical cell cultures .

HY-110188

BiP inducer X 5 Publications Verification	Apoptosis	Neurological Disease
BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress .

HY-121859

RU28362	Glucocorticoid Receptor	Metabolic Disease
RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion . RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P5756

CSD-CH2(1,8)-NH2	Opioid Receptor	Neurological Disease
CSD-CH2(1,8)-NH2 is a selective and competitive KOR antagonist (K_i: 6.8 nM). CSD-CH2(1,8)-NH2 inhibits calcium mobilization in DRG neurons. CH2(1,8)-NH2 antagonizes the antinociceptive effect of U50,488. CSD-CH2(1,8)-NH2 can be used for research of neuropsychiatric disorders .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1304A

(+)-Sparteine sulfate pentahydrate 1 Publications Verification (+)-Lupinidine sulfate pentahydrate	Alkaloids Piperidine Alkaloids other families Source classification Plants	nAChR
(+)-sparteine (sulfate pentahydrate) is a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons .

HY-100355

C18-Ceramide	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
C18-Ceramide can promote exocytosis of glutamate from damaged neurons. C18-Ceramide promotes cell death in glioma cells. Ceramides is involved in diverse cellular functions, such as differentiation, cell cycle progression, cell-cell adhesion, senescence, and apoptosis .

HY-136341

7,8-Dihydroneopterin	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Apoptosis NO Synthase Endogenous Metabolite
7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases .

HY-N0076

Bilobalide 2 Publications Verification (-)-Bilobalide	Structural Classification Ginkgoaceae Terpenoids Sesquiterpenes Source classification Plants Endogenous metabolite Ginkgo biloba	Apoptosis Autophagy Endogenous Metabolite
Bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba, inhibits the NMDA-induced efflux of choline with an IC₅₀ value of 2.3 µM. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. Exerts protective and trophic effects on neurons .

HY-W010410

Oct-1-en-3-ol	Microorganisms Source classification Plants	Others
Oct-1-en-3-ol, a fatty acid fragrant, is a self-stimulating oxylipin messenger. Oct-1-en-3-ol serves as a signaling molecule in plant cellular responses, plant-herbivore interactions, and plant-plant interactions. Oct-1-en-3-ol causes dopamine neuron degeneration through disruption of dopamine handling .

HY-W074890

Palmitoylglycine N-palmitoyl glycine	Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Calcium Channel NO Synthase
Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA .

HY-121252

Dopal	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite Reactive Oxygen Species α-synuclein
Dopal is an aldehyde that can be generated in Parkinson's disease by enzymatic degradation of dopamine. Dopal can generate reactive oxygen species, and triggers aggregation of α-synuclein. DOPAL elicits α-synuclein accumulation and hampers α-synuclein clearance in primary neurons .

HY-P1293

Conantokin G	Structural Classification Natural Products Animals Source classification	iGluR
Conantokin G, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G inhibits NMDA-evoked currents in murine cortical neurons with an IC₅₀ of 480 nM. Conantokin G has neuroprotective properties .

HY-P1293A

Conantokin G TFA	Natural Products Animals Source classification	iGluR
Conantokin G TFA, a 17-amino-acid peptide, is a potent, selective and competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. Conantokin G TFA inhibits NMDA-evoked currents in murine cortical neurons with an IC₅₀ of 480 nM. Conantokin G TFA has neuroprotective properties .

HY-N0076R

Bilobalide (Standard)	Structural Classification Ginkgoaceae Terpenoids Sesquiterpenes Source classification Plants Endogenous metabolite Ginkgo biloba	Apoptosis Autophagy Endogenous Metabolite
Bilobalide (Standard) is the analytical standard of Bilobalide. This product is intended for research and analytical applications. Bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba, inhibits the NMDA-induced efflux of choline with an IC50 value of 2.3 μM. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. Exerts protective and trophic effects on neurons .

HY-B1906

Streptomycin Maximum Cited Publications 24 Publications Verification Agrept; Agrimycin; Streptomycin A	Microorganisms Source classification	Antibiotic Bacterial
Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .

HY-N0532

Morroniside	Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	MMP Pyroptosis Apoptosis
Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.

HY-W008350

(+)-Sparteine 1 Publications Verification Pachycarpine	Alkaloids Piperidine Alkaloids Structural Classification other families Source classification Plants	nAChR
(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.

HY-N0061

Ethyl ferulate 1 Publications Verification	Structural Classification Monophenols Simple Phenylpropanols Source classification Phenols Dicerothamnus rhinocerotis Phenylpropanoids Umbelliferae Plants	Reactive Oxygen Species
Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress . Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity .

HY-N1978

3'-Methoxypuerarin	Structural Classification Flavonoids Pueraria edulis Pampan. Leguminosae Source classification Phenols Polyphenols Plants Isoflavones	Others
3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity.

HY-N1838

Dehydromaackiain	Structural Classification Natural Products Leguminosae Source classification Plants Butea superba Roxb. ex Willd.	Others
Dehydromaackiain is a potent Neurogenin2 (Ngn2) promoter activator. Dehydromaackiain promotes differentiation of neural stem cells into neurons .

HY-N1363

Royal Jelly acid 4 Publications Verification Queen Bee Acid; (E)-10-Hydroxy-2-decenoic acid	Structural Classification Animals Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Royal Jelly acid (Queen Bee Acid) is a fatty acid constituent of royal jelly, promotes the growth and protection of neurons, reduces anxiety-like phenotypes .

HY-N0663

Talatisamine	Alkaloids Pyrrole Alkaloids Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants	Potassium Channel
Talatisamine, a aconitum alkaloid, is specific K ⁺ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons .

HY-N6825

Hydroxy-α-sanshool 3 Publications Verification	Zanthoxylum bungeanum Maxim. Alkaloids Structural Classification Other Alkaloids Source classification Rutaceae Plants Endogenous metabolite	TRP Channel Endogenous Metabolite
Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC₅₀s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research .

HY-135013

Umbellulone	Structural Classification Other Monoterpenes Terpenoids Source classification Myrtaceae Plants Myrtus communis L.	TRP Channel
Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism .

HY-113416

Dehydroepiandrosterone sulfate 4 Publications Verification DHEA sulfate; Prasterone sulfate	Human Gut Microbiota Metabolites Microorganisms Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses .

HY-N0949

(-)-Variabilin	Structural Classification Natural Products Leguminosae Source classification Plants Butea superba Roxb. ex Willd.	Others
(-)-Variabilin (compound 13) is an Neurogenin2 (Ngn2) promoter activator isolated from Butea superba. (-)-Variabilin promotes differentiation of neural stem cells into neurons .

HY-N7368

Hibifolin	Flavonols Structural Classification Flavonoids other families Neurological Disease Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Adenosine Deaminase
Hibifolin, a flavonol glycoside, is a potential inhibitor of adenosine deaminase (ADA), with a K_i of 49.92 μM. Hibifolin protects neurons against beta-amyloid-induced neurotoxicity .

HY-113053

Prostaglandin A1	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite Apoptosis
Prostaglandin A1 is a dehydration derivate of Prostaglandin E1. Prostaglandin A1 exhibits inhibitory activities against tumor growth, inflammation, virus replication, platelet aggregation and excitotoxin-induced neurons apoptosis .

HY-N6951

Guaiazulene	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Other Diseases Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Guaiazulene is present in several essential oils of medicinal and aromatic plants, with antioxidant activity. Guaiazulene has in vitro cytotoxic activity against neuron and N2a neuroblastom (N2a-NB) cells .

HY-N9246

4'-Methoxyflavanone	Structural Classification Flavonoids Microorganisms Flavonones Source classification	Others
4'-Methoxyflavanone is a flavonoid compound. 4'-Methoxyflavanone is isolated from the natural Isaria fumosorosea KCH J2. 4'-Methoxyflavanone regulates metabolic disorders, prevents cardiovascular disease and protects neurons .

HY-N12277

Celosin K	Structural Classification Celosia argentea Linn. Polysaccharides Source classification Amaranthaceae Plants Saccharides	Apoptosis
Celosin K (compound 8) can be isolated from the seeds of Semen Celosiae. Celosin K is a potent inhibitor of neuron injury elicited by t-BHP. Celosin K inhibits oxidative stress and apoptosis, and acts of autophagy .

HY-B0282

Acetylcholine chloride 10+ Cited Publications ACh chloride	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	nAChR Calcium Channel Endogenous Metabolite
Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

HY-N0109

Salidroside Maximum Cited Publications 24 Publications Verification Rhodioloside	Structural Classification Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Phenols Plants Disease Research Fields Cancer	PINK1/Parkin mTOR Apoptosis Prolyl Endopeptidase (PREP)
Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

HY-129692

Withanone 1 Publications Verification	Structural Classification Source classification Withania somnifera Plants Solanaceae Steroids	iGluR
Withanone is an active constituent from Withania somnifera roots with multifunctional neuroprotective effect in alleviating cognitive dysfunction. Withanone affords protection against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in Neuron-like cells .

HY-N12921

(E)-8-Dodecenol	Structural Classification Natural Products Animals Source classification	Others
(E)-8-Dodecenol is a pheromone that increases the frequency of electro-pulse spikes in mid-receptor neurons of codling moth (Cydia pomonella L.). (E)-8-Dodecenol is isolated from female codling moths .

HY-N1978R

3'-Methoxypuerarin (Standard)	Structural Classification Flavonoids Pueraria edulis Pampan. Leguminosae Source classification Phenols Polyphenols Plants Isoflavones	Others
3'-Methoxypuerarin (Standard) is the analytical standard of 3'-Methoxypuerarin. This product is intended for research and analytical applications. 3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity.

HY-128900

11-cis-Vaccenyl acetate	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
11-cis-Vaccenyl acetate is male-specific lipid that mediates aggregation behavior in both male and female flies, which activates a few dozen olfactory neurons located in T1 sensilla on the antenna of both male and female flies .

HY-N7368R

Hibifolin (Standard)	Flavonols Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants	Adenosine Deaminase
Hibifolin (Standard) is the analytical standard of Hibifolin. This product is intended for research and analytical applications. Hibifolin, a flavonol glycoside, is a potential inhibitor of adenosine deaminase (ADA), with a Ki of 49.92 μM. Hibifolin protects neurons against beta-amyloid-induced neurotoxicity .

HY-113416R

Dehydroepiandrosterone sulfate (Standard)	Human Gut Microbiota Metabolites Microorganisms Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Dehydroepiandrosterone sulfate (Standard) is the analytical standard of Dehydroepiandrosterone sulfate. This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses .

HY-N2160

6'''-Feruloylspinosin	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	GABA Receptor
6'''-Feruloylspinosin is a flavonoid isolated from seeds of Ziziphus jujuba. 6'''-Feruloylspinosin can across the blood-brain barrier and enhance the expression of GABAAα1, GABAAα5, and GABABR1 mRNA in rat hippocampal neurons .

HY-114883

Homocarnosine L-Homocarnosine; γ-Aminobutyryl-L-histidine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	GABA Receptor Endogenous Metabolite
Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects .Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-N6951R

Guaiazulene (Standard)	Structural Classification other families Terpenoids Sesquiterpenes Source classification Plants Endogenous metabolite	Endogenous Metabolite
Guaiazulene (Standard) is the analytical standard of Guaiazulene. This product is intended for research and analytical applications. Guaiazulene is present in several essential oils of medicinal and aromatic plants, with antioxidant activity. Guaiazulene has in vitro cytotoxic activity against neuron and N2a neuroblastom (N2a-NB) cells .

HY-114883A

Homocarnosine TFA L-Homocarnosine TFA; γ-Aminobutyryl-L-histidine TFA	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	GABA Receptor Endogenous Metabolite
Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects . Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-B0282R

Acetylcholine chloride (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	nAChR Calcium Channel Endogenous Metabolite
Acetylcholine (chloride) (Standard) is the analytical standard of Acetylcholine (chloride). This product is intended for research and analytical applications. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) . Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro .

HY-129692R

Withanone (Standard)	Structural Classification Source classification Withania somnifera Solanaceae Plants Steroids	iGluR
Withanone (Standard) is the analytical standard of Withanone. This product is intended for research and analytical applications. Withanone is an active constituent from Withania somnifera roots with multifunctional neuroprotective effect in alleviating cognitive dysfunction. Withanone affords protection against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in Neuron-like cells .

HY-N10512

Gangliotetraose Gg4	Structural Classification Polysaccharides Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Saccharides	Others
Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca ²⁺ and reduces the level of nuclear Ca ²⁺ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain .

HY-N0911

Rehmannioside A 1 Publications Verification	Structural Classification Polysaccharides Classification of Application Fields Source classification Other Diseases Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Disease Research Fields Saccharides	NF-κB Apoptosis p38 MAPK
Rehmannioside A is a neuroprotective agent that can be isolated from Rehmanniae radix. Rehmannioside A can inhibit the release of proinflammatory mediators from microglia and promote M2 polarization in vitro, thereby protecting co-cultured neurons from apoptosis by inhibiting NF-κB and MAPK signaling pathways. Rehmannioside A can be used in spinal cord injury research .

HY-17389

Genipin 10+ Cited Publications (+)-Genipin	Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Plants Endogenous metabolite Human Gut Microbiota Metabolites Iridoids Terpenoids Rubiaceae Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	Autophagy
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research .

HY-N1500

Pulegone 1 Publications Verification	Other Monoterpenes Classification of Application Fields Glycyrrhiza aspera Pall. Terpenoids Labiatae Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	TRP Channel Endogenous Metabolite
Pulegone, the major chemical constituent of Nepeta catariaessential oil which is an aromatic herb, is one of avian repellents . The molecular target for the repellent action of Pulegone in avian species is nociceptive TRP ankyrin 1 (TRPA1). Pulegone stimulates both TRPM8 and TRPA1 channel in chicken sensory neurons and suppresses the former but not the latter at high concentrations .

HY-12546

Brevetoxin B Brevetoxin-2; PbTx-2	Natural Products Microorganisms Animals Source classification	Sodium Channel
Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC₅₀=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.

HY-N0109R

Salidroside (Standard) Rhodioloside (Standard)	Structural Classification Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Source classification Phenols Plants Disease Research Fields Cancer	Prolyl Endopeptidase (PREP) mTOR Apoptosis PINK1/Parkin
Salidroside (Standard) is the analytical standard of Salidroside. This product is intended for research and analytical applications. Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy .

HY-N2500

Deoxypodophyllotoxin	Infection Cardiovascular Disease Structural Classification other families Classification of Application Fields Source classification Centaurea ornata Lignans Phenylpropanoids Plants Umbelliferae Disease Research Fields	Microtubule/Tubulin Apoptosis Autophagy
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis . Deoxypodophyllotoxin induces cell autophagy and apoptosis . Deoxypodophyllotoxin evokes increase of intracellular Ca ²⁺ concentrations in DRG neurons .

HY-128850

N-Acetyl-D-mannosamine N-Acetylmannosamine; ManNAc	Structural Classification Natural Products Human Gut Microbiota Metabolites Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders .

HY-12688

Succinyl phosphonate	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite Reactive Oxygen Species
Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts . Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner . Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ .

Cat. No.	Product Name	Chemical Structure

HY-B0194S

Tizanidine-d4
Tizanidine-d₄ is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons[1][2].

HY-W008719S

MPP+-d3(iodide)

MPP+-d₃ (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

HY-109101S

Risdiplam-d4
Risdiplam-d₄ is deuterium labeled Risdiplam. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels[1].

HY-N7063S1

Nerol-d6
Nerol-d₆ is deuterated labeled Oct-1-en-3-ol (HY-W010410). Oct-1-en-3-ol, a fatty acid fragrant, is a self-stimulating oxylipin messenger. Oct-1-en-3-ol serves as a signaling molecule in plant cellular responses, plant-herbivore interactions, and plant-plant interactions. Oct-1-en-3-ol causes dopamine neuron degeneration through disruption of dopamine handling .

HY-132409S

Monocrotophos-d6
Monocrotophos-d₆ is the deuterium labeled Monocrotophos. Monocrotophos. Monocrotophos is an organophosphate insecticide with broad application in crops. Monocrotophos inhibits the activity of the acetylcholine esterase (AChE) enzyme and affects the neurotransmission between neurons[1].

HY-121636S

Resolvin D2-d5
Resolvin D2-d₅ is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

HY-B0887S1

Permethrin-d9
Permethrin-d₉ is the deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation.

HY-W751099

Corticosterone-13C3
Corticosterone- ¹³C₃ is a ¹³C-labeled corticosterone (HY-B1618). Corticosterone (17-Deoxycortisol) is an orally available glucocorticoid that can regulate limbic system neurons and has good immunosuppressive activity.

HY-109101AS1

Risdiplam-hydroxylate-d3
Risdiplam-hydroxylate-d₃ is a Risdiplam-hydroxylate tritium substitute. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

HY-109101AS2

Risdiplam-hydroxylate-d6
Risdiplam-hydroxylate-d₆ is a Risdiplam-hydroxylate tritium substitute. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

HY-139145S

Etbicyphat-13C3
Etbicyphat- ¹³C₃ is the ¹³C labeled Etbicyphat (HY-139145). Etbicyphat is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors[1][2].

HY-B0887S

Permethrin-d5
Permethrin-d₅ (NRDC-143-d5) is the deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation[1][2].

HY-B1176S

Equilin-d4
Equilin-d₄ is the deuterium labeled Equilin. Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism[1][2].

HY-B0696AS

Tiagabine-d4 hydrochloride
Tiagabine-d₄ hydrochloride is deuterated labeled Tiagabine hydrochloride (HY-B0696A). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC₅₀s of 67, 446 and 182 nM for [ ³H]GABA uptake in Synaptosomes, Neurons and Glia, respectively .

HY-B0282S

Acetylcholine-d4 chloride

Acetylcholine-d₄ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-B0282S1

Acetylcholine-d9 chloride

Acetylcholine-d₉ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-107116S

MAP4343-d4
MAP4343-d₄ is the deuterium labeled MAP4343. MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2][3].

HY-15121S

L-Theanine-d5

L-Theanine-d₅ is the deuterium labeled L-Theanine. L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake[1][2][3].

HY-N5142S1

α-Terpineol-d6

α-Terpineol-d₆ is deuterated labeled Pulegone (HY-N1500). Pulegone, the major chemical constituent of Nepeta catariaessential oil which is an aromatic herb, is one of avian repellents . The molecular target for the repellent action of Pulegone in avian species is nociceptive TRP ankyrin 1 (TRPA1). Pulegone stimulates both TRPM8 and TRPA1 channel in chicken sensory neurons and suppresses the former but not the latter at high concentrations .

HY-10232S

THIP-d4

THIP-d4 (Gaboxadol-d4) is the deuterium labeled THIP (HY-10232). THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC₅₀ value of 13 μM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect on miniature IPSCs. THIP can be used in studies of sleep disorders .

HY-103309S

ML218-d9

ML218-d₉ is the deuterium labeled ML218. ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier[1].

HY-B0822S1

Fipronil-13C6

Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-N6746S1

Citrinin-13C13

Citrinin- ¹³C₁₃ (NSC 186- ¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-B0358AS

Flunarizine-d8 dihydrochloride
Flunarizine-d₈ dihydrochloride is deuterated labeled Flunarizine dihydrochloride (HY-B0358A). Flunarizine dihydrochloride is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

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