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Results for "

COX

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (628) 5-HT Receptor (2) Acyltransferase (3) Adrenergic Receptor (1) Akt (5) Aldose Reductase (1) AMPK (4) Amyloid-β (2) Antibiotic (6) Apoptosis (105) Autophagy (45) Bacterial (30) Bcl-2 Family (5) Beta-secretase (2) Biochemical Assay Reagents (1) c-Fms (1) Calcium Channel (7) CaMK (1) Carbonic Anhydrase (5) Caspase (9) Cathepsin (1) Chloride Channel (6) Cholinesterase (ChE) (4) CMV (2) Cytochrome P450 (3) DAGL (1) Dengue virus (1) Dopamine Receptor (2) Drug Metabolite (13) EGFR (1) Endogenous Metabolite (64) Epoxide Hydrolase (2) ERK (7) Estrogen Receptor/ERR (3) FAAH (5) Ferroptosis (10) Flavivirus (1) Fluorescent Dye (1) Fungal (4) GABA Receptor (2) Glucocorticoid Receptor (1) GLUT (2) Glutathione Peroxidase (2) HDAC (2) Histone Acetyltransferase (7) HIV (1) HSV (2) IGF-1R (2) IKK (5) Influenza Virus (14) Interleukin Related (12) Isotope-Labeled Compounds (51) JNK (1) Leukotriene Receptor (6) Lipoxygenase (45) LOX-1 (1) mAChR (1) Macrophage migration inhibitory factor (MIF) (2) MAP3K (1) MEK (1) Melatonin Receptor (4) Microtubule/Tubulin (3) Mitophagy (16) MMP (7) Monoamine Oxidase (1) NF-κB (69) NO Synthase (38) NOD-like Receptor (NLR) (1) Notch (2) Opioid Receptor (1) p38 MAPK (16) Parasite (18) PGE synthase (16) Phosphatase (1) Phospholipase (4) PI3K (4) PKA (1) PKC (1) Potassium Channel (5) PPAR (9) Progesterone Receptor (3) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (10) PTEN (2) RAR/RXR (1) Reactive Oxygen Species (21) Ribosomal S6 Kinase (RSK) (2) SARS-CoV (2) Sirtuin (1) Small Interfering RNA (siRNA) (23) SOD (2) Sodium Channel (1) Src (1) STAT (1) Survivin (1) TGF-β Receptor (1) TNF Receptor (16) Toll-like Receptor (TLR) (3) Topoisomerase (2) Transthyretin (TTR) (2) TRP Channel (3) Tyrosinase (1) VEGFR (2) Virus Protease (8) Wnt (2) Xanthine Oxidase (1) β-catenin (2)
By Research Areas:	Cancer (278) Cardiovascular Disease (41) Endocrinology (13) Infection (43) Inflammation/Immunology (583) Metabolic Disease (44) Neurological Disease (47)
Click Chemistry:	Azide (4) Alkynes (1)
Oligonucleotides:	Antioxidants (1) Preservatives (1) Pre-designed siRNA Sets (23) Chelating Agents (1) siRNAs (23)

752

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

201

Natural
Products

Recombinant Proteins

106

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: COX

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155764

COX-1/2-IN-4	COX	Cancer
COX-1/2-IN-4 (compound 2b) is anCOX inhibitorwith IC₅₀ values of 0.239 μM and 0.191 μM for COX-1 enzyme and COX-2 enzyme , respectively. COX-1/2-IN-4showsmoderateanticanceractivity against COLO205 and B16F1 cancer cell lines with IC₅₀ values of 30.79 and 74.15 μM, respectively .

HY-146675

COX/5-LOX-IN-1	COX	Inflammation/Immunology
COX/5-LOX-IN-1 (compound 6b) is a potent and dual inhibitor of *COX/5-LOX* with IC₅₀s of 1.07, 0.55, and 0.28 μM for COX-1, COX-2, and 5-LOX enzyme, respectively. COX/5-LOX-IN-1 has the potential for the research of inflammation diseases .

HY-147692

COX-2-IN-14	COX	Inflammation/Immunology
COX-2-IN-14 (compound 2a) is a potent and selective *COX-2* (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice .

HY-163355

COX-2/15-LOX-IN-5	COX Lipoxygenase NF-κB	Inflammation/Immunology
COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities .

HY-162167

COX-1-IN-1	COX	Cardiovascular Disease Neurological Disease
COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase (COX), with IC₅₀s of 0.23 μM (COX-1) and >50 μM (COX-2), selective index (COX-2 IC₅₀/COX-1 IC₅₀) is 217. COX-1-IN-1 inhibits platelet aggregation .

HY-161862

COX-2-IN-44	COX	Inflammation/Immunology
COX-2-IN-44 is a potent and orally active *COX-2* inhibitor with IC₅₀ values of 0.18,1.14 µM for COX-2, COX-1, respectively. COX-2-IN-44 shows anti-inflammatory activity .

HY-147961

COX-2-IN-23	COX	Inflammation/Immunology
COX-2-IN-23 (compound 9a) is a selective *COX-2* inhibitor with IC₅₀ values of 0.28 and 20.14 μM for COX-2 and COX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity.

HY-161294

COX-2-IN-41	COX	Cancer
COX-2-IN-41 (compound 5e) is a selective inhibitor of COX-2 (IC₅₀=1.74 μM). Compared with COX-1, the selectivity IC₅₀ (COX-1)/IC₅₀(COX-2) =16.32 .

HY-163509

COX-2-IN-43	COX Apoptosis	Cancer
COX-2-IN-43 (Compound MYM4) is a *COX-2* inhibitor (IC₅₀: 0.983 and 0.247 μM for COX-1 and COX-2 respectively). COX-2-IN-43 inhibits cancer cell proliferation and colonization, induces apoptosis .

HY-150550

COX-2-IN-26	COX	Inflammation/Immunology
COX-2-IN-26 is a potent, selective and orally active *COX-2* inhibitor with IC₅₀ values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile .

HY-150551

COX-2-IN-27	COX	Inflammation/Immunology
COX-2-IN-27 is a potent and selective *COX-2* inhibitor with IC₅₀ values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity .

HY-150553

COX-2-IN-28	COX	Inflammation/Immunology
COX-2-IN-28 is a potent and selective *COX-2* inhibitor with IC₅₀ values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively .

HY-115866

COX-2-IN-6	COX	Cancer
COX-2-IN-6 (compound 10) is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. COX-2-IN-6 selectively targets COX-2 with an IC₅₀ of 0.84 μM and a Ki of 69 nM. COX-2-IN-6 also inhibits COX-2-driven PGE2 synthesis with an IC₅₀ of 0.60 μM .

HY-115934

COX-2-IN-7	COX	Inflammation/Immunology
COX-2-IN-7 (compound 4a) is a potent, selective, and orally active inhibitor of *COX-2* with an IC₅₀ of 6.585 uM. COX-2-IN-7 has higher COX-2 selectivity than Celecoxib. COX-2-IN-7 shows good in vivo anti-inflammatory and low ulcerogenic activity .

HY-115935

COX-2-IN-8	COX	Inflammation/Immunology
COX-2-IN-8 (compound 6a) is a potent, selective, and orally active inhibitor of *COX-2* with an IC₅₀ of 6.585 uM. COX-2-IN-8 has higher COX-2 selectivity than Celecoxib. COX-2-IN-8 shows good in vivo anti-inflammatory and low ulcerogenic activity .

HY-115936

COX-2-IN-9	COX	Inflammation/Immunology
COX-2-IN-9 (compound 7a) is a potent, selective, and orally active inhibitor of *COX-2* with an IC₅₀ of 10.17 uM. COX-2-IN-9 has higher COX-2 selectivity than Celecoxib. COX-2-IN-9 shows good in vivo anti-inflammatory and low ulcerogenic activity .

HY-147794

COX-2-IN-18	COX	Cancer
COX-2-IN-18 (Compound 3) is a potent inhibitor of *COX-2. COX-2-IN-18 possesses good COX-2 inhibitory activity (IC₅₀* = 0.775 μM) compared to the reference agent, Celecoxib (IC₅₀ = 0.153 μM). COX-2-IN-18 has the potential for the research of cancer diseases .

HY-115976

COX-2-IN-10	COX	Inflammation/Immunology
COX-2-IN-10 is a potent *COX-2* inhibitor. COX-2-IN-10 inhibits the production of PGE₂ in concentration dependent manner (IC₅₀=2.54 µM). COX-2-IN-10 inhibits the expression of iNOS and *COX-2* on mRNA and protein level . COX-2-IN-10 inhibits the production of IL-6, TNF-α and IL-1β .

HY-147719

COX-2-IN-16	COX	Inflammation/Immunology
COX-2-IN-16 (compound 2b) is a potent, selective and orally active *COX-2* inhibitor with an IC₅₀ of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity .

HY-156254

COX-2-IN-35	COX	Inflammation/Immunology
COX-2-IN-35 (compound 7) is a selective *COX-2* inhibitor with an IC₅₀ of 4.37 nM. COX-2-IN-35 has anti-inflammatory activity .

HY-146371

COX-2-IN-13	COX	Inflammation/Immunology
COX-2-IN-13 (compound 13e) is a potent and selective inhibitor of *COX-2* with an IC₅₀ of 0.98 μM. COX-2-IN-13 is an anti-inflammatory agent. COX-2-IN-13 shows safety in-vivo acute toxicity study .

HY-146370

COX-2-IN-12	COX	Inflammation/Immunology
COX-2-IN-12 (compound 3b) is a potent and selective inhibitor of *COX-2* with an IC₅₀ of 19.98 μM. COX-2-IN-12 is an anti-inflammatory agent. COX-2-IN-12 shows safety in-vivo acute toxicity study .

HY-169167

COX-2-IN-49	COX	Cancer
COX-2-IN-49 (compound 6c) is a potent cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ value of 2.671 µM. COX-2-IN-49 shows antiproliferative activity. COX-2-IN-49 has the potential for the research of cancer .

HY-145988

COX-2-IN-11	COX	Inflammation/Immunology
COX-2-IN-11 (compound 7b2) is a potent and selective inhibitor of *COX-2. COX*-2-IN-11 has the potential for the research of inflammation diseases .

HY-162244

COX-2-IN-40	COX	Inflammation/Immunology
COX-2-IN-40 (compound 17) is a *COX-2* inhibitor with the IC₅₀ of 14.86 μM. COX-2-IN-40 can be used for study of chronic pain .

HY-146198

COX-2-IN-19	COX	Inflammation/Immunology
COX-2-IN-19 (Compound 24) is a potent *COX-2* inhibitor with an IC₅₀ of 1.76 μM. COX-2-IN-19 shows in vivo anti-inflammatory activity .

HY-116947

COX-2-IN-5	COX	Inflammation/Immunology
COX-2-IN-5 (compound 11a) is a potent *COX-2* inhibitor with an IC₅₀ value of 0.65 µM. COX-2-IN-5 has the potential for the research of inflammation .

HY-161147

COX-2-IN-37	COX	Inflammation/Immunology
COX-2-IN-37 (compound 11) is a potent and selective *COX-2* inhibitor. COX-2-IN-37 has strong antioxidant activity with an IC₅₀ of 33.0 μg/mL .

HY-161994

COX-2-IN-47	COX	Inflammation/Immunology
COX-2-IN-47 (compound 6c ) is a selective *COX-2* inhibitor with IC₅₀ value of 0.03 μM. COX-2-IN-47 has antiedema activity .

HY-168070

COX-2-IN-48	COX NF-κB NO Synthase	Inflammation/Immunology
COX-2-IN-48 (5-25), a *COX-2* inhibitor with an IC₅₀ of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, the phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS .

HY-147809

COX-2-IN-20	COX	Inflammation/Immunology
COX-2-IN-20 (Compound 5d) is a selective and orally active *COX-2* inhibitor with an IC₅₀ of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity .

HY-U00275

COX-2-IN-1	COX	Inflammation/Immunology
COX-2-IN-1 is potent and slective *COX-2* inhibitor with an IC₅₀ of 3.9 μM.

HY-147748

COX-2-IN-17	COX	Inflammation/Immunology
COX-2-IN-17 (compound 10) is a potent and BBB-penetrated *COX-2* (cyclooxygenase-2) inhibitor, with an IC₅₀ of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase .

HY-153762

COX-2-IN-32	NO Synthase NF-κB COX	Inflammation/Immunology
COX-2-IN-32 (Compound 2f) is an iNOS and *COX-2* inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC₅₀: 11.2 μM) .

HY-147815

COX-2-IN-21	COX	Inflammation/Immunology
COX-2-IN-21 (Compound 5c) is a selective and orally active *COX-2* inhibitor with an IC₅₀ of 0.039 μM. COX-2-IN-21 shows promising anti-inflammatory potential .

HY-147693

COX-1/2-IN-3	COX	Inflammation/Immunology
COX-1/2-IN-3 (Compound 7a) is a *COX-1* and *COX-2* inhibitor. COX-2-IN-15 shows anti-inflammatory activity with low toxicity .

HY-149269

COX-2-IN-30	COX Carbonic Anhydrase LOX-1	Inflammation/Immunology
COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of *COX* (IC₅₀=49 nM for COX-2, 10.4 μM for COX-1) and 5-LOX (IC₅₀=2.4 μM). COX-2-IN-30 also inhibits transmembrane hCA IX and hCA XII isoform with nanomolar calss K_i values. COX-2-IN-30 exhibits analgesic, anti-inflammatory, and ulcerogenic activities, and does not show acute gastric effect .

HY-155133

COX-2-IN-34	COX	Inflammation/Immunology
COX-2-IN-34 (compound 8a) is a selective and orally active inhibitor of COX-2 , with an IC₅₀ of 0.42 μM. COX-2-IN-34 has no gastric ulcer toxicity but has anti-inflammatory effects .

HY-159562

COX-2-IN-46	COX	Inflammation/Immunology
COX-2-IN-46 (compound 5m) is an anti-inflammatory agent with potent analgesic activity. COX-2-IN-46 exhibits a significant inhibitory effect on *COX-2* (IC₅₀=87.74 nM) .

HY-159561

COX-1-IN-2	COX	Inflammation/Immunology
COX-1-IN-2 (compound 5h) is an anti-inflammatory agent with potent analgesic activity. COX-1-IN-2 exhibits a significant inhibitory effect on *COX-1* (IC₅₀=38.76 nM) .

HY-157578

COX-2-IN-38	COX	Inflammation/Immunology
COX-2-IN-38 (compound 52) is a potent inhibitor of COX*-2, with the IC₅₀ value of 79.4 nM .

HY-157583

COX-2-IN-39	COX	Others
COX-2-IN-39 (compound 44) is a potent inhibitor of *COX*-2, with the IC₅₀ value of 0.4 nM .

HY-121679

COX-2-IN-50	Others	Neurological Disease
COX-2-IN-50 is a water-soluble COX-2 inhibitor with significant analgesic activity. The solubility of COX-2-IN-50 in water reaches 20.3 mg/mL, far exceeding the 1.6 μg/mL of its precursor compound PC407. COX-2-IN-50 demonstrates good biocompatibility and is suitable for the development of injectable dosage forms. COX-2-IN-50 has proven its analgesic effect in vivo and shows potential application value .

HY-101655

COX-2-IN-2	COX	Inflammation/Immunology
COX-2-IN-2 is a selective and inducible *COX2* inhibitor with an IC₅₀ of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.

HY-115966

COX-1/2-IN-1	COX	Inflammation/Immunology
COX-1/2-IN-2 is a potent *COX1/2* inhibitor. COX-1/2-IN-2 exhibits significant inhibitory effect against COX-1 and COX-2 inhibitor with IC₅₀ values of 13.9 ± 3.21 µM and 6.4±0.74 µM, respectively .

HY-115967

COX-1/2-IN-2	COX	Inflammation/Immunology
COX-1/2-IN-2 is a potent *COX1/2* inhibitor. COX-1/2-IN-2 exhibits significant inhibitory effect against COX-1 and COX-2 inhibitor with IC₅₀ values of 9.7 ± 0.09 µM and 4.6 ± 1.45 µM, respectively .

HY-150721

COX-2-IN-29	COX	Neurological Disease Inflammation/Immunology
COX-2-IN-29 (Compound 15b) is a selective and orally active *COX-2* inhibitor with an IC₅₀ of 0.005 μM .

HY-105304

COX-2-IN-36	COX	Inflammation/Immunology
COX-2-IN-36 (compound 1) is a very potent and specific *COX-2* inhibitor, with an IC₅₀ of 0.4 μM .

HY-162385

COX-2-IN-42	COX	Inflammation/Immunology
COX-2-IN-42 (Compound T1) is a *COX-2* inhibitor, and protects zebrafish against PTZ-induced neuronal damage .

HY-149355

COX-2-IN-33	COX	Inflammation/Immunology
COX-2-IN-33 (compound 5f) is a *COX-2* inhibitor (IC₅₀=45.5 nM), as well as a potential anti-inflammatory agent. COX-2-IN-33 inhibits in vivo pro-inflammatory cytokine production and keep gastric safety .

Cat. No.	Product Name

HY-L130

Non-steroidal Anti-Inflammatory Compound Library

614 compounds

Non-steroidal anti-inflammatory drugs (NSAIDs) are members of a therapeutic drug class with potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. The most prominent NSAIDs are aspirin, ibuprofen, and naproxen.

The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX), based on which NSAIDs can be classified into two types: non-selective and COX-2 selective. Most NSAIDs are non-selective and inhibit both COX-1 and COX-2 activity.

MCE offers a unique collection of 614 non-steroidal compounds with identified anti-inflammatory activity. MCE non-steroidal anti-inflammatory library is a useful tool for the study of anti-inflammatory drugs and pharmacology.

HY-L077

Anti-Pancreatic Cancer Compound Library

2,892 compounds

Pancreatic cancer is a devastating disease with a low overall survival rate. Chemotherapy is the most common treatment for patients presenting with advanced pancreatic cancer. More recently, the era of targeted therapies has generated a lot of interest in discovering better approaches for patients with pancreatic cancer. Commonly mutated genes in pancreatic cancer include K-ras (in 74-100% of cases), p16INK4a (up to 98%), p53 (43 to 76%), DPC4 (about 50%), HER-2/neu (in about 65%) and FHIT (found in 70% of cases). Other genes involved are notch1, Akt-2, BRCA2 and COX-2. These proteins are important targets of target therapies for pancreatic cancer.

MCE offers a unique collection of 2,892 compounds with identified and potential anti- pancreatic cancer activity. These compounds target K-Ras, p53, HER2, Notch, AKT, etc. MCE anti-pancreatic cancer compound library is a useful tool for anti-pancreatic cancer drugs screening and other related research.

HY-L034

Anti-Aging Compound Library

4,757 compounds

Aging is a complex biological process characterized by functional decline of tissues and organs, structural degeneration, and reduced adaptability and resistance, all of which contribute to an increase in morbidity and mortality caused by multiple chronic diseases, such as Alzheimer's disease, cancer, and diabetes. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. The programmed theories imply that aging relies on specific gene regulation, and the error theories emphasize the internal and environmental damages accumulated to living organisms. The damage theories proposed the nine hallmarks that were generally considered to contribute to the aging process: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.

MCE Anti-Aging Compound Library contains 4,757 compounds, mainly targeting Sirtuin, mTOR, IGF-1R, AMPK, p53, Telomerase, Mitophagy, Mitochondrial Metabolism, COX, Cytochrome P450, Oxidase, etc. This library is a useful tool for anti-aging research.

HY-L007

Immunology/Inflammation Compound Library

5,514 compounds

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation.

MCE designs a unique collection of 5,514 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

Cat. No.	Product Name	Type

HY-14397G

Indomethacin (GMP)

Indometacin (GMP)

Fluorescent Dye

Indomethacin (GMP) is Indomethacin (HY-14397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .

HY-D2297

AIE-GA	Fluorescent Dyes/Probes
AIE-GA is a Golgi apparatus (GA) fluorescent probe (green channel: λex = 405 nm, λem = 500-700 nm). AIE-GA has a favourable binding ability to interact with COX-2. AIE-GA binds to the cyclooxygenase catalytic site of COX-2 .

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	Fluorescent Dye
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

HY-14398G

Celecoxib (GMP) SC 58635 (GMP)	Fluorescent Dye
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

Cat. No.	Product Name	Type

HY-14397G

Indomethacin (GMP)

Indometacin (GMP)

Biochemical Assay Reagents

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	Biochemical Assay Reagents
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

HY-14398G

Celecoxib (GMP) SC 58635 (GMP)	Biochemical Assay Reagents
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

HY-59302

Indole-5-carboxylic acid, 98%	Cell Assay Reagents
Indole-5-carboxylic acid, 98% is an oxytocin that interacts with serotonin receptors and gamma-aminobutyric acid (GABA) receptors. It has also been reported to interact with various enzymes such as cyclooxygenase-2 (COX-2) and 5-hydroxytryptamine (5-HT) receptors.

HY-131384

8,11,14-Eicosatriynoic acid

8,11,14-Icosatriynoic acid

Biochemical Assay Reagents

8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W009248

Phenethyl ferulate	Monophenols Classification of Application Fields Source classification Phenols Plants Umbelliferae Kleinia odora (Forssk.) DC. Disease Research Fields Inflammation/Immunology	COX Lipoxygenase
Phenethyl ferulate is a major constituent ofQianghuo, shows inhibitory activity against cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) with IC₅₀ values of 4.35 μM and 5.75 μM, respectively .

HY-15762

Valdecoxib 3 Publications Verification SC 65872	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX Endogenous Metabolite
Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX*-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-N0481

Roburic acid	Triterpenes Structural Classification Gentiana macrophylla Pall. Classification of Application Fields Terpenoids Source classification Gentianaceae Plants Inflammation/Immunology Disease Research Fields	COX
Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of *COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX*-2, respectively .

HY-N0356

(-)-Catechin gallate 1 Publications Verification (-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate	Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae Cancer	COX
(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of *COX-1* and *COX-2* enzymes.

HY-100580

Asaraldehyde Asaronaldehyde; Asaraldehyde; 2,4,5-trimethoxy-Benzaldehyde	Acorus tatarinowii Schott Structural Classification Classification of Application Fields Araceae Ketones, Aldehydes, Acids Source classification Plants Inflammation/Immunology Disease Research Fields	COX
Asarylaldehyde (Asaronaldehyde), a *COX-2* inhibitor, significantly inhibits cyclooxygenase II (COX-2) activity with an IC₅₀ value of 100 μg/mL .

HY-N8184

4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone	Dracaena cochinchinensis (Lour.) S. C. Chen Classification of Application Fields Source classification Phenols Polyphenols Agavaceae Plants Disease Research Fields Inflammation/Immunology	COX
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits *COX-1* and *COX-2* inhibitory activity .

HY-B1227

Carprofen 2 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX FAAH Autophagy Endogenous Metabolite
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target *FAAH/COX* inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-152120

(±)-Aiphanol Aiphanol	Structural Classification Source classification Phenols Polyphenols Arecaceae Plants Aiphanes aculeata Willd	COX VEGFR
(±)-Aiphanol is a newly discovered stilbenolignan analog. (±)-Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of *COX-1* and *COX-2. The inhibitory effect on COX-1 (IC₅₀ = 1.9 μM) is particularly strong, while the effect on COX-2 (IC₅₀= 9.9 μM) is relatively weak .(±)-Aiphanol effectively inhibits VEGFR2* (IC₅₀=0.92 µM). (±)-Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (±)-Aiphanol is orally active .

HY-N11624

Axinelline A	Structural Classification Microorganisms Source classification Phenols Polyphenols	COX
Axinelline A is a potent *COX* inhibitor with IC₅₀s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity .

HY-15762R

Valdecoxib (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	COX Endogenous Metabolite
Valdecoxib (Standard) is the analytical standard of Valdecoxib. This product is intended for research and analytical applications. Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX*-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-N0481R

Roburic acid (Standard)	Triterpenes Structural Classification Gentiana macrophylla Pall. Terpenoids Source classification Gentianaceae Plants	COX
Roburic acid (Standard) is the analytical standard of Roburic acid. This product is intended for research and analytical applications. Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX-2, respectively .

HY-N2266

Benzoylgomisin O	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Inflammation/Immunology Disease Research Fields	COX
Benzoylgomisin O isolated from Schisandra rubriflora, has inhibitory activity against 15-LOX, *COX-1* and *COX-2* enzymes and anti-inflammatory activity .

HY-126121

2-Hydroxy Ibuprofen (±)-2-Hydroxy Ibuprofen	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	COX
2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-N2599

Taraxerol acetate	Triterpenes Structural Classification Classification of Application Fields Terpenoids Astragalus oleifolius DC. Source classification Plants Compositae Disease Research Fields Cancer	COX Apoptosis
Taraxerol acetate is a *COX-1* and *COX-2* inhibitor with IC₅₀ values of 116.3 μM and 94.7 μM, respectively. Taraxerol acetate the has the anticancer potential and induces cell apoptosis .

HY-N0929

Hexahydrocurcumin	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Curcuma longa Disease Research Fields Zingiberaceae Cancer	COX Reactive Oxygen Species
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active *COX-2* inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-N11880

2-O-Sinapoyl makisterone A	Structural Classification Source classification Fibraurea recisa Pierre Plants Menispermaceae Steroids	COX
2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein .

HY-100580R

Asaraldehyde (Standard)	Acorus tatarinowii Schott Structural Classification Araceae Ketones, Aldehydes, Acids Source classification Plants	COX
Asaraldehyde (Standard) is the analytical standard of Asaraldehyde. This product is intended for research and analytical applications. Asarylaldehyde (Asaronaldehyde), a COX-2 inhibitor, significantly inhibits cyclooxygenase II (COX-2) activity with an IC₅₀ value of 100 μg/mL .

HY-B1227R

Carprofen (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	COX FAAH Autophagy Endogenous Metabolite
Carprofen (Standard) is the analytical standard of Carprofen. This product is intended for research and analytical applications. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-N0356R

(-)-Catechin gallate (Standard)	Structural Classification Flavonoids Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Theaceae	COX
(-)-Catechin gallate (Standard) is the analytical standard of (-)-Catechin gallate. This product is intended for research and analytical applications. (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.

HY-B0367R

Lornoxicam (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	COX Endogenous Metabolite
Lornoxicam (Standard) is the analytical standard of Lornoxicam. This product is intended for research and analytical applications. Lornoxicam (Chlortenoxicam) is a highly active COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM respectively. It is a new non-steroidal anti-inflammatory compound.

HY-N0767

Isoorientin 5 Publications Verification Homoorientin	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	COX
Isoorientin is a potent inhibitor of *COX-2* with an IC₅₀ value of 39 μM.

HY-N6891

Hamaudol	Monophenols Classification of Application Fields Ophryosporus axilliflorus Hieron. Ketones, Aldehydes, Acids Source classification Phenols Plants Umbelliferae Disease Research Fields Inflammation/Immunology	COX
Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and *COX-2* activities with IC₅₀ values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects .

HY-N8167

Plantanone B Kaempferol 3-O-rhamnosylgentiobioside	Flavonols Structural Classification Flavonoids Classification of Application Fields Camellia oleifera Abel. Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Theaceae	COX
Plantanone B is a moderate antioxidant-agent with an IC₅₀ of 169.8±5.2 μM. Plantanone B shows significant ovine COX-1 and moderate COX-2 inhibitory activities. Plantanone B has the potential for inflammation-related diseases research .

HY-N0389

Columbin 1 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	COX Parasite
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits *COX-2* (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) .

HY-N0929R

Hexahydrocurcumin (Standard)	Structural Classification Source classification Phenols Polyphenols Plants Curcuma longa Zingiberaceae	COX Reactive Oxygen Species
Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-N0355

(+)-Catechin hydrate 10+ Cited Publications	Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae Cancer	COX
(+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-N0932

Catechin hydrate (+)-Catechin hydrate; Cianidanol hydrate; Catechuic acid hydrate	Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae Cancer	COX
Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Apoptosis COX NO Synthase Interleukin Related Prostaglandin Receptor TNF Receptor
Lornoxicam (Chlortenoxicam) is an orally active oxycontin nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antipyretic and anticancer activities. Lornoxicam exhibits good inhibitory effects on both *COX-1* and *COX-2* (COX-1: IC₅₀=0.005 μM; *COX-2:IC₅₀*=0.008 μM) and inhibits the production of NO by iNOS (IC₅₀=65 μM) and the proinflammatory cytokine IL-6 (IC₅₀=54 μM). Lornoxicam also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis. Lornoxicam can be used in the study of inflammatory pain, colorectal cancer and breast cancer .

HY-N0346A

(E)-Ethyl p-methoxycinnamate	Structural Classification Classification of Application Fields Source classification Plants Infection Kaempferia galanga L. Simple Phenylpropanols Alpinia officinarum Hance Phenylpropanoids Inflammation/Immunology Disease Research Fields Zingiberaceae Cancer	COX
(E)-Ethyl p-methoxycinnamate is a natural product found in Kaempferia galangal with anti-inflammatory, anti-neoplastic and anti-microbial effects. (E)-Ethyl p-methoxycinnamate inhibits *COX-1* and *COX-2* in vitro with IC₅₀s of 1.12 and 0.83 μM, respectively .

HY-N0898

Catechin 10+ Cited Publications (+)-Catechin; Cianidanol; Catechuic acid	Structural Classification Classification of Application Fields Anti-aging Source classification Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Flavonoids Microorganisms Sunscreen Flavanols Phenols Polyphenols Cosmetic Research Disease Research Fields Theaceae Cancer	COX Apoptosis Influenza Virus Endogenous Metabolite
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-N0147

Rutaecarpine 5 Publications Verification Rutecarpine	Alkaloids Structural Classification Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Plants Disease Research Fields Indole Alkaloids Cancer	COX
Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of *COX-2* with an IC₅₀ value of 0.28 μM.

HY-112731

TFAP N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	COX Endogenous Metabolite
TFAP is a selective cyclooxygenase-1 *(COX-1)* inhibitor, with an IC₅₀ of 0.8 μM.

HY-126121R

2-Hydroxy Ibuprofen (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	COX
2-Hydroxy Ibuprofen (Standard) is the analytical standard of 2-Hydroxy Ibuprofen. This product is intended for research and analytical applications. 2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.

HY-N2176

S-(+)-Marmesin (+)-Marmesin; (S)-Marmesin	Structural Classification Classification of Application Fields Source classification Other Diseases Coumarins Phenylpropanoids Umbelliferae Plants Disease Research Fields Bidens parviflora Willd.	COX Lipoxygenase
S-(+)-Marmesin is a natural coumarin, exhibiting *COX-2/5-LOX* dual inhibitory activity.

HY-N1067

Xanthohumol 5+ Cited Publications	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields	COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), *COX-1* and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-N0002

(-)-Epicatechin gallate 4 Publications Verification Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate	Structural Classification Classification of Application Fields Source classification Camellia sinensis (L.) O. Ktze. Plants Flavonoids Microorganisms Flavanols Phenols Polyphenols Disease Research Fields Theaceae Cancer	COX Autophagy Virus Protease
(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM.

HY-N8469

cis-5-Dodecenoic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Inflammation/Immunology Disease Research Fields	Endogenous Metabolite COX
cis-5-Dodecenoic acid is an endogenous metabolite with inhibitory activities against *COX-I* and *COX-II* .

HY-122953

Daturaolone	Triterpenes Structural Classification Datura innoxia Miller Terpenoids Source classification Plants Solanaceae	COX
Daturaolone is a natural triterpenoid with anti-inflammatory and antinociceptive potentials. Daturaolone displays a *COX-1* inhibitory activity .

HY-129113

α-Chaconine	Alkaloids Piperidine Alkaloids Structural Classification Zea mays L. Pyrrole Alkaloids Classification of Application Fields Gramineae Source classification Plants Inflammation/Immunology Disease Research Fields	COX
α-Chaconine inhibits the expressions of *COX-2, IL-1β, IL-6, and TNF-α* at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and *COX-2* at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-137011

3,9-Dihydroeucomin	Structural Classification Flavonoids Ledebouria socialis (Baker) Jessop Flavones Source classification Plants Asparagaceae Juss.	COX
3,9-Dihydroeucomin (compound 12) is a natural homoisoflavonoid compound with less COX-2 inhibitory activitys .

HY-N0389R

Columbin (Standard)	Structural Classification other families Terpenoids Source classification Diterpenoids Plants	COX Parasite
Columbin (Standard) is the analytical standard of Columbin. This product is intended for research and analytical applications. Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) .

HY-N12708

23-O-β-D-Glucopyranosyl-20-isoveratramine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Plants Melanthiaceae Veratrum oxysepalum Turcz.	Others
23-O-β-D-Glucopyranosyl-20-isoveratramine is a potential anti-allergic agent extracted from nettles. A variety of COX-1, COX-2, 5-lipoxygenase and trypsin-like inhibitors and H1 antagonists are found in nettle extract, which can inhibit seasonal allergies, allergic rhinitis and other inflammatory diseases. and preventive effects .

HY-N1380

Guaiacol 2-Methoxyphenol	Structural Classification Human Gut Microbiota Metabolites Monophenols Microorganisms other families Classification of Application Fields Phenols Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX NF-κB Endogenous Metabolite
Guaiacol, a phenolic compound, inhibits LPS-stimulated *COX-2* expression and NF-κB activation . Anti-inflammatory activity .

HY-124481

Oleocanthal	Structural Classification Monophenols Canarium album (Lour.) Rauesch. Source classification Phenols Plants Burseraceae	COX
Oleocanthal is a *COX-1/2* enzyme inhibitor and a nonsteroidal anti-inflammatory agent. Oleocanthal is obtained from virgin olive oil .

HY-N0074

Byakangelicol 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt. Inflammation/Immunology Disease Research Fields	COX
Byakangelicol, isolated from Angelica dahurica, inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of cyclooxygenase-2 (COX-2) expression and the activity of COX-2 enzyme. Byakangelicol has therapeutic potential as an anti-inflammatory agent on airway inflammation .

HY-W109812

Sinapyl alcohol 1 Publications Verification	Structural Classification Monophenols Microorganisms Source classification Phenols	COX
Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and *COX-2* .

HY-N1067R

Xanthohumol (Standard)	Structural Classification Chalcones Flavonoids Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae	COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol (Standard) is the analytical standard of Xanthohumol. This product is intended for research and analytical applications. Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-B0167

Salicylic acid 5+ Cited Publications 2-Hydroxybenzoic acid	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Agricultural Research Monophenols Microorganisms other families Ketones, Aldehydes, Acids Phenols Phytohormone Inflammation/Immunology Disease Research Fields Cancer	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-N5015

Rosmanol	Structural Classification Brachyclados megalanthus Speg. Classification of Application Fields Labiatae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	COX
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-N0493

Pectolinarigenin 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Campylotropis hirtella (Franch.) Schindl. Source classification Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	COX Lipoxygenase
Pectolinarigenin is a dual inhibitor of *COX-2/5-LOX*. Anti-inflammatory activity . Pectolinarigenin has potent inhibitory activities on melanogenesis .

Species:	Human (4) Virus (2)
Tag:	SUMO (1) His (4) Fc (2)
Source:	Sf9 insect cells (3) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P75686

	COX5B Protein, Human (His) Cytochrome c oxidase subunit 5B, mitochondrial; COX5B	Human	E. coli
	The COX5B protein is a component of cytochrome c oxidase, the final enzyme in the mitochondrial electron transport chain. COX5B Protein, Human (His) is the recombinant human-derived COX5B protein, expressed by E. coli , with N-His labeled tag. The total length of COX5B Protein, Human (His) is 98 a.a., with molecular weight of ~14 kDa.

HY-P74222

	COX-2 Protein, Human (sf9, His) Prostaglandin G/H synthase 2; COX-2; PGHS-2	Human	Sf9 insect cells
	COX-2 protein is involved in the alternative pathway of prostaglandin biosynthesis. COX-2 Protein, Human (sf9, His) is the recombinant human-derived COX-2 protein, expressed by Sf9 insect cells , with C-10*His labeled tag.

HY-P72150

	COX4I1 Protein, Human (His-SUMO) AL024441; COX 4; COX IV 1; COX IV; COX IV-1; COX4; COX41_HUMAN; COX4a; COX4B; COX4I1; COX4I2; COX4L2; COXIV; Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit 4 isoform 1 mitochondrial; Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; Cytochrome C Oxidase subunit IV; Cytochrome c oxidase subunit IV isoform 1; Cytochrome c oxidase subunit IV isoform 2 lung; ; Cytochrome c oxydase subunit 4; dJ857M17.2; MGC105470; MGC72016	Human	E. coli
	The COX4I1 protein is a component of cytochrome c oxidase, the final enzyme in the mitochondrial electron transport chain responsible for oxidative phosphorylation. COX4I1 Protein, Human (His-SUMO) is the recombinant human-derived COX4I1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of COX4I1 Protein, Human (His-SUMO) is 147 a.a., with molecular weight of ~33.2 kDa.

HY-P77342

	COX4NB Protein, Human (His) ER membrane protein complex subunit 8; Neighbor of COX4; C16orf2; COX4AL; COX4NB; FAM158B; NOC4	Human	E. coli
	COX4NB protein is a component of the endoplasmic reticulum membrane protein complex (EMC) and is able to insert newly synthesized membrane proteins into the endoplasmic reticulum membrane in an energy-independent manner. Its preference for transmembrane domains with weakly hydrophobic or unstable characteristics guides co- and post-translational insertion processes. COX4NB Protein, Human (His) is the recombinant human-derived COX4NB protein, expressed by E. coli , with N-His labeled tag. The total length of COX4NB Protein, Human (His) is 210 a.a., with molecular weight of ~27 kDa.

HY-P76280

	Coxsackievirus A16 VP1 Protein (295a.a, sf9, Fc) COXsackievirus A16 (COX A16) (strain G-10) VP4 Protein; VP1 Protein; CV	Virus	Sf9 insect cells
	Coxsackievirus A16 (CVA16) can cause hand-foot-and-mouth disease (HFMD). CVA16 is a small, non-enveloped, icosahedral particle containing a single-stranded, positive-sense viral RNA genome of approximately 7.4 kb in length. CVA16 can be cleaved by viral proteases into 4 structural (VP1 to VP4) and 7 nonstructural (2A to 2C, and 3A to 3D) proteins. CVA16 interacts with its host receptors (cell surface heparan sulfate glycosaminoglycans and SCARB2 as its uncoating receptor) to enter into susceptible cells. Upon binding, CVA16 mature virions may transform to an uncoating intermediate state. Coxsackievirus A16 VP1 Protein is one of the capsid subunit protein of cleaved CVA16. Coxsackievirus A16 VP1 Protein (295a.a, sf9, Fc) is the recombinant Virus-derived Coxsackievirus A16 VP1 protein, expressed by Sf9 insect cells , with C-hFc labeled tag.

HY-P76281

	Coxsackievirus A16 VP4 Protein (68a.a, sf9, Fc) COXsackievirus A16 (COX A16) (strain G-10) VP4 Protein; VP4 Protein; CV	Virus	Sf9 insect cells
	Coxsackievirus A16 (CVA16) can cause hand-foot-and-mouth disease (HFMD). CVA16 is a small, non-enveloped, icosahedral particle containing a single-stranded, positive-sense viral RNA genome of approximately 7.4 kb in length. CVA16 can be cleaved by viral proteases into 4 structural (VP1 to VP4) and 7 nonstructural (2A to 2C, and 3A to 3D) proteins. CVA16 interacts with its host receptors (cell surface heparan sulfate glycosaminoglycans and SCARB2 as its uncoating receptor) to enter into susceptible cells. Upon binding, CVA16 mature virions may transform to an uncoating intermediate state. Coxsackievirus A16 VP1 Protein is one of the capsid subunit protein of cleaved CVA16. Coxsackievirus A16 VP4 Protein (68a.a, sf9, Fc) is the recombinant Virus-derived Coxsackievirus A16 VP4 protein, expressed by Sf9 insect cells , with C-rFc labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-15036S1

Diclofenac-13C6
Diclofenac- ¹³C₆ is the ¹³C₆ labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15037S1

Diclofenac-d4 sodium

Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-15036S

Diclofenac-d4
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-B0580S

Ketorolac-d5
Ketorolac-d₅ is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1].

HY-15321S

Etoricoxib-d4 1 Publications Verification
Etoricoxib-d₄ is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-B0808S1

Oxaprozin-d5
Oxaprozin-d₅ is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.

HY-15037S2

Diclofenac-13C6 sodium

Diclofenac- ¹³C₆ (Sodium) is the ¹³C₆ labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15762S

Valdecoxib-d3
Valdecoxib-d₃ is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain[1][2].

HY-15037S

Diclofenac-13C6 sodium heminonahydrate

Diclofenac- ¹³C₆ (sodium heminonahydrate) is the ¹³C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-17372S

Rofecoxib-d5
Rofecoxib-d₅ is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells)[1][2].

HY-B0367S

Lornoxicam-d4
Lornoxicam-d₄ is the deuterium labeled Lornoxicam. Lornoxicam (Chlortenoxicam), a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory agent (NSAID).

HY-B0261S1

Meloxicam-d3-1
Meloxicam-d₃-1 is the deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-B0253S

Piroxicam-d3
Piroxicam-d₃ is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively [1].

HY-B0261S

Meloxicam-d3
Meloxicam-d₃ is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively[1].

HY-14654S

Aspirin-d3
Aspirin-d₃ is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.

HY-78131S

Ibuprofen-d3
Ibuprofen-d₃ is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM[1].

HY-B0580S1

Ketorolac-d4
Ketorolac-d₄ (RS37619 D4) is the deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1][2].

HY-B0253S1

Piroxicam-d4
Piroxicam-d₄ is the deuterium labeled Piroxicam. Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively.

HY-B0261S2

Meloxicam-13C,d3
Meloxicam- ¹³C,d₃ is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-14397S

Indomethacin-d4
Indomethacin-d₄ is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

HY-B0008S

Sulindac-d3
Sulindac-d₃ is deuterium labeled Sulindac. Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2.

HY-B0227S1

Ketoprofen-d4
Ketoprofen-d₄ is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

HY-B0227S

Ketoprofen-d3
Ketoprofen-d₃ is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

HY-14397S1

Indomethacin-d4 Methyl Ester
Indomethacin-d₄ Methyl Ester is the deuterium labeled Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

HY-15321S1

Etoricoxib-13C,d3
Etoricoxib- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoricoxib. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-B0335S1

Tolfenamic acid-13C6
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-15321S2

Etoricoxib-d3
Etoricoxib-d₃ is the deuterium labeled Etoricoxib[1]. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood[2][3][4].

HY-14654S1

Aspirin-d4
Aspirin-d₄ is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL[1][2].

HY-B0335S

Tolfenamic Acid-D4
Tolfenamic acid-d₄ is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1[1][2].

HY-14397S2

Indometacin-d7
Indometacin-d₇ is deuterated labeled Indomethacin (HY-14397). Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .

HY-B1227S

Carprofen-d3
Carprofen-d₃ is the deuterium labeled Carprofen. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-B0578S

Loxoprofen-d4
Loxoprofen-d₄ is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively[1][2].

HY-14670S

Firocoxib-d4
Firocoxib-d₄ (ML 1785713-d4) is the deuterium labeled Firocoxib. Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC50 of 7.5 μM). Firocoxib has anti-inflammatory effects[1].

HY-105028S

Tenidap-d3
Tenidap-d₃ is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor[3].

HY-N0356S

(+/-)-Catechin Gallate-13C3
(+/-)-Catechin Gallate- ¹³C₃ is the ¹³C-labeled (-)-Catechin gallate. (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.

HY-B0227S2

Ketoprofen-13C,d3
Ketoprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

HY-78131S1

Ibuprofen-13C,d3
Ibuprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Ibuprofen. Ibuprofen is an anti-inflammatory agent targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.

HY-B0360S

Rebamipide-d4
Rebamipide-d₄ is deuterium labeled Rebamipide. Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner[1].

HY-B0619S1

Zaltoprofen-13C,d3
Zaltoprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Zaltoprofen. Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain[1][2][3].

HY-B1227S1

Carprofen-13C,d3
Carprofen- ¹³C,d₃ is the deuterium and ¹³C labeled Carprofen[1]. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively[2][3][4].

HY-15029S2

(±)-Naproxen-13C,d3
(±)-Naproxen- ¹³C,d₃ is the deuterium and ¹³C labeled (±)-Naproxen[1]. (±)-Naproxen ((Rac)-Naproxen) is a racemate of Naproxen (HY-15030). Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively.

HY-B1888AS

Bromfenac-d4 sodium

Bromfenac-d₄ (sodium) is deuterium labeled Bromfenac (sodium). Bromfenac sodium is a potent and orally active inhibitor of COX, with IC50s of 5.56 and 7.45 nM for COX-1 and COX-2, respectively. Bromfenac sodium is a brominated non-steroidal anti-inflammatory/analgesic agent (NSAID), and it is commonly used for the research of postoperative inflammation and pain following cataract surgery, and pseudophakic cystoid macular edema (CME)[1][2].

HY-17357S

Nepafenac-d5
Nepafenac-d₅ is the deuterium labeled Nepafenac, which is a selective COX-2 inhibitor.

HY-126121S

2-Hydroxy Ibuprofen-d6
2-Hydroxy Ibuprofen-d₆ is the deuterium labeled 2-Hydroxy Ibuprofen. 2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1][2].

HY-78131AS

(S)-(+)-Ibuprofen D3
(S)-(+)-Ibuprofen-d₃ is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].

HY-B0363S

Nimesulide D5
Nimesulide-d₅ is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties[1][2].

HY-N0898S

Catechin-13C3
Catechin- ¹³C₃ is the ¹³C-labeled Catechin. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.

HY-B1279AS

Metamizole-d3 sodium
Metamizole-d3 sodium is the deuterium labeled Metamizole sodium. Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole sodium is a cyclooxygenase-3 (COX-3) inhibitor .

HY-14398S1

Celecoxib-d3
Celecoxib-d₃ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

HY-14398S

Celecoxib-d7
Celecoxib-d₇ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80089

	COX IV Antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
	COX IV Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 20 kDa, targeting to COX IV. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80090

	COX2 Antibody	WB, IHC-P, FC	Human, Rat
	COX2 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 69 kDa, targeting to COX2. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human, Rat.

HY-P81025

	COX IV Antibody (YA867)	WB, IHC-F, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat, Hamster, Goat, Monkey
	COX IV Antibody (YA867) is an unconjugated, approximately 20 kDa, mouse-derived, anti-COX IV (YA867) monoclonal antibody. COX IV Antibody (YA867) can be used for: WB, IHC-F, IHC-P, ICC/IF, IP, FC expriments in human, mouse, rat, hamster, goat, monkey background without labeling.

HY-P80091

	COX2/Cyclooxygenase 2 Antibody 1 Publications Verification PTGS2; COX 2; COX2; COX-2; Cyclooxygenase; Cyclooxygenase2; Cyclooxygenase-2; hCOX 2; PGG/HS; PGH synthase 2; PGHS 2; PGHS2; PHS 2; PHS II; PHS2 ; Prostaglandin endoperoxide synthase 2; Prostaglandin G/H synthase 2 precursor; Prostaglandin G/H synthase and cyclooxygenase; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; TIS10II; PGH2_HUMAN.	WB, ICC/IF, IHC-P	Human, Rat
	COX2/Cyclooxygenase 2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 69 kDa, targeting to COX2/Cyclooxygenase 2. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Rat.

HY-P83509

	MTCO2 Antibody (YA3254) MT-CO2; COX2; CO2; Cytochrome c oxidase II; MTCO2; COII; COXII	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	MTCO2 Antibody (YA3254) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3254), targeting MTCO2, with a predicted molecular weight of 26 kDa (observed band size: 21 kDa). MTCO2 Antibody (YA3254) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

HY-P82796

	Cyclooxygenase 2 Antibody (YA2541) Cyclooxygenase-2; COX-2; Glucocorticoid-regulated inflammatory cyclooxygenase; Gripghs; PES-2; PHS II; Prostaglandin H2 synthase 2	WB, ICC/IF, IP	Mouse
	Cyclooxygenase 2 Antibody (YA2541) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2541), targeting Cyclooxygenase 2, with a predicted molecular weight of 69 kDa (observed band size: 74 kDa). Cyclooxygenase 2 Antibody (YA2541) can be used for WB, ICC/IF, IP experiment in mouse background.

HY-P82805

	COX5B Antibody (YA2550) COX5B; Cytochrome c oxidase subunit 5B; mitochondrial; Cytochrome c oxidase polypeptide Vb	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	COX5B Antibody (YA2550) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2550), targeting COX5B, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). COX5B Antibody (YA2550) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P82792

	Cyclooxygenase 1 Antibody (YA2537) PTGS1; COX1; Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Cyclooxygenase 1 Antibody (YA2537) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2537), targeting Cyclooxygenase 1, with a predicted molecular weight of 69 kDa (observed band size: 69 kDa). Cyclooxygenase 1 Antibody (YA2537) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-119647

PPOH		Alkynes
PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. In addition, PPOH acts on CYP4A2 and CYP4A3 with the IC₅₀ values of 22 μM and 6.5 μM, respectively . PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159562

COX-2-IN-46		Azide
COX-2-IN-46 (compound 5m) is an anti-inflammatory agent with potent analgesic activity. COX-2-IN-46 exhibits a significant inhibitory effect on *COX-2* (IC₅₀=87.74 nM) .

HY-159561

COX-1-IN-2		Azide
COX-1-IN-2 (compound 5h) is an anti-inflammatory agent with potent analgesic activity. COX-1-IN-2 exhibits a significant inhibitory effect on *COX-1* (IC₅₀=38.76 nM) .

HY-159564

*iNOS/COX-2-IN-3*		Azide
iNOS/COX-2-IN-3 (compound 7d) is a dual inhibitor of iNOS and *COX-2, with potential anti-inflammatory activity against LPS (HY-D1056)-induced RAW 264.7 cells (IC₅₀=3.48 μM). iNOS/COX-2-IN-3 has good plasma stability, oral activity and gastric safety, and its inhibitory activity on iNOS* and *COX-2* expression is 5.43-fold and 2.37-fold that of Indomethacin (HY-14397), respectively .

HY-159169

5-LOX/sEH-IN-1		Azide
5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC₅₀ values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of *COX-2* (IC₅₀=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects .

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