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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

ADC synthesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (9) ADC Cytotoxin (49) ADC Linker (653) DNA/RNA Synthesis (5) Drug-Linker Conjugates for ADC (69) Amino Acid Derivatives (1) Antibiotic (3) Apoptosis (2) Bacterial (5) Bcl-2 Family (1) CD22 (1) CDK (1) DNA Alkylator/Crosslinker (4) Drug Metabolite (1) EGFR (3) Estrogen Receptor/ERR (2) Glucocorticoid Receptor (1) IGF-1R (1) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (5) Kinesin (1) Mesothelin (1) Microtubule/Tubulin (9) NAMPT (2) Notch (1) PROTAC Linkers (210) PROTACs (2) Radionuclide-Drug Conjugates (RDCs) (1) STING (2) TAM Receptor (1) Telomerase (1) TNF Receptor (1) Topoisomerase (27) TROP2 (1)
By Research Areas:	Cancer (831) Infection (6) Inflammation/Immunology (32) Neurological Disease (1)
Click Chemistry:	ADC Synthesis (231) TCO (16) DBCO (52) PROTAC Synthesis (57) Azide (82) BCN (26) Tetrazine (31) Alkynes (47)

848

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

247

Click Chemistry

Targets Recommended: DNA/RNA Synthesis ADC Cytotoxin ADC Antibody ADC Linker Drug-Linker Conjugates for ADC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-20336

Mc-Val-Cit-PABC-PNP 2 Publications Verification Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate	ADC Linker	Others Inflammation/Immunology Cancer
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs .

HY-128979B

Deruxtecan analog 2 monoTFA	Drug-Linker Conjugates for ADC	Cancer
Deruxtecan analog 2 (monoTFA) is a homolog of Deruxtecan (HY-13631E), a conjugate of the ADC toxin DX-8951 derivative (Dxd) with an ADC Linker .

HY-42146

BMPS	ADC Linker	Cancer
BMPS is a nonclaevable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-139441

DM21	Drug-Linker Conjugates for ADC	Cancer
DM21 is a conjugate of a cleavable ADC agent and a linker (ADC linker) used in the synthesis of antibody-drug conjugates (ADCs) .

HY-125933

Val-Ala-PAB	ADC Linker	Cancer
Val-Ala-PAB is a cleavable ADC linker that can be used for *ADCs* synthesis .

HY-150074

STING agonist-18	Others	Cancer
STING agonist-18 (compound 1a) can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate .

HY-150074A

STING agonist-18 diTFA	Others	Cancer
STING agonist-18 diTFA (compound 1a) can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate .

HY-131081

γ-Amanitin	DNA/RNA Synthesis ADC Cytotoxin	Cancer
γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC₅₀ of 163.1 ng/mL .

HY-129366

PDB-Pfp	ADC Linker	Cancer
PDB-Pfp is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-128970

Mp-polymer ester	ADC Linker	Cancer
Mp-polymer ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-126531

DMAC-PDB	ADC Linker	Cancer
DMAC-PDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-114697

DSG Crosslinker Disuccinimidyl glutarate	ADC Linker	Inflammation/Immunology
DSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-118759

DSP Crosslinker 1 Publications Verification	ADC Linker	Inflammation/Immunology
DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs) .

HY-140098

Boc-Cystamine	ADC Linker	Cancer
Boc-Cystamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-140014

Val-Cit	ADC Linker	Cancer
Val-Cit is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-126349

DTSSP Crosslinker	ADC Linker	Cancer
DTSSP Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-101151

sulfo-SPDB	ADC Linker	Cancer
sulfo-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-130111

DMAC-SPP	ADC Linker	Cancer
DMAC-SPP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-126405

SMPT	ADC Linker	Cancer
SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W071006

PPC-NHS ester 2,5-Dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate	ADC Linker	Cancer
PPC-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-133540

Maleimide-DOTA 2 Publications Verification Maleimido-mono-amide-DOTA	ADC Linker	Inflammation/Immunology Cancer
Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-133542

Dimethylamine-SPDB	ADC Linker	Cancer
Dimethylamine-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-133543

SPDP-sulfo	ADC Linker	Cancer
SPDP-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-133550

DMAC-SPDB	ADC Linker	Cancer
DMAC-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-150043A

MDTF	ADC Linker	Cancer
MDTF is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-155870

DL-01	Drug-Linker Conjugates for ADC	Cancer
DL-01 is a drug-linker conjugates for ADC that can be used for the synthesis of ADCs .

HY-125305

Z-AEVD-FMK	ADC Linker	Cancer
Z-AEVD-FMK is a cleavable ADC linker for the synthesis of antibody active molecule conjugates (ADCs).

HY-160157

IM-2	Drug-Linker Conjugates for ADC	Cancer
IM-2 is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-160776

Diazido-methyltetrazine tri-arm	ADC Linker	Cancer
Diazido-methyltetrazine tri-arm is a polyvalent ADC linker and can be used for synthesis of ADCs .

HY-W034595

Eicosanedioic acid	ADC Linker PROTAC Linkers	Cancer
Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

HY-160790

β-Glu-PNP	ADC Linker	Cancer
β-Glu-PNP is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-41919

Mal-L-PA-NH-Boc mDPR(boc); (S)-MALEOYL-DPR(BOC)-OH·DCHA	ADC Linker	Cancer
Mal-L-PA-NH-Boc is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-140129

NHS-SS-biotin	ADC Linker	Cancer
NHS-SS-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-140096

Aminoethyl-SS-propionic acid	ADC Linker	Cancer
Aminoethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-140987

5-Maleimidovaleric acid	ADC Linker	Cancer
5-Maleimidovaleric acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-140122

THP-SS-alcohol	ADC Linker	Cancer
THP-SS-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-126495A

Sulfo-LC-SPDP sodium	ADC Linker	Cancer
Sulfo-LC-SPDP sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W002213

N-Hydroxysulfosuccinimide sodium	ADC Linker	Cancer
N-Hydroxysulfosuccinimide (sodium) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W019543

DSS Crosslinker 4 Publications Verification	ADC Linker	Cancer
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W011541

SIA Crosslinker Iodoacetic acid N-hydroxysuccinimide ester; N-Succinimidyl Iodoacetate	ADC Linker	Cancer
SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-126364

Mc-Val-Ala-PAB	ADC Linker	Cancer
Mc- Val- Ala- PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-130110

Sulfo-DMAC-SPP	ADC Linker	Cancer
Sulfo-DMAC-SPP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-141158

N-(Iodoacetamido)-Doxorubicin	ADC Linker	Cancer
N-(Iodoacetamido)-Doxorubicin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-131084

DMAC-SPDB-sulfo	ADC Linker	Cancer
DMAC-SPDB-sulfo is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-138327

1,6-Bis(mesyloxy)hexane	ADC Linker	Cancer
16-Bismesyloxyhexane is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W096127

Biotin-sar-oh	ADC Linker	Cancer
Biotin-sar-oh is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-147118

NHS-SS-Ph	ADC Linker	Cancer
NHS-SS-Ph is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-150043

MDTF free acid	ADC Linker	Cancer
MDTF free acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-155870A

DL-01 formic	Drug-Linker Conjugates for ADC	Cancer
DL-01 formic is a drug-linker conjugates for ADC that can be used for the synthesis of ADCs .

HY-160408

Mal-GGG-Bal-NHS ester	ADC Linker	Cancer
Mal-GGG-Bal-NHS ester is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

Cat. No.	Product Name	Type

HY-126851

Fluorescein-DBCO	Dyes
Fluorescein-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Fluorescein-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-123687

DBCO-Sulfo-NHS ester sodium	Dyes
DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-Sulfo-NHS ester (sodium) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-78921AG

Fmoc-3VVD-OH (GMP)	Fluorescent Dye
Fmoc-3VVD-OH (GMP) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-131833G

Fmoc-Gly-Gly-Phe-OH (GMP)	Fluorescent Dye
Fmoc-Gly-Gly-Phe-OH GMP is a GMP grade Fmoc-Gly-Gly-Phe-OH (HY-131833). Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-20336G

Mc-Val-Cit-PABC-PNP (GMP)	Fluorescent Dye
Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-78738G

MC-Val-Cit-PAB (GMP)	Fluorescent Dye
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

HY-78931G

Boc-Dap-NE (GMP)	Fluorescent Dye
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-78932G

Dap-NE hydrochloride (GMP)	Fluorescent Dye
Dap-NE hydrochloride (GMP) is Dap-NE hydrochloride (HY-78932A) produced by using GMP guidelines. Dap-NE hydrochloride is an intermediate used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W000423G

DBCO-amine (GMP)	Fluorescent Dye
DBCO-amine GMP is a GMP grade DBCO-amine (HY-W000423). DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-amine is a click chemistry reagent, itcontains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-16700G

PNU-159682 (GMP)	Fluorescent Dye
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

HY-42972G

DBCO-acid (GMP)

Fluorescent Dye

DBCO-acid GMP is a GMP grade DBCO-acid (HY-42972). DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690) . DBCO-acid is a click chemistry reagent, itcontains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-131990G

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)	Fluorescent Dye
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-131990). MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-45672G

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)	Fluorescent Dye
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-45672). Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate .

Cat. No.	Product Name	Type

HY-78921AG

Fmoc-3VVD-OH (GMP)	Biochemical Assay Reagents
Fmoc-3VVD-OH (GMP) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-135928

Biotin-C2-S-S-pyridine	Biochemical Assay Reagents
Biotin-C2-S-S-pyridine is a cleavable ADC linker. Biotin-C2-S-S-pyridine can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-131833G

Fmoc-Gly-Gly-Phe-OH (GMP)	Biochemical Assay Reagents
Fmoc-Gly-Gly-Phe-OH GMP is a GMP grade Fmoc-Gly-Gly-Phe-OH (HY-131833). Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-20336G

Mc-Val-Cit-PABC-PNP (GMP)	Biochemical Assay Reagents
Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-78738G

MC-Val-Cit-PAB (GMP)	Biochemical Assay Reagents
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

HY-78931G

Boc-Dap-NE (GMP)	Biochemical Assay Reagents
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-78932G

Dap-NE hydrochloride (GMP)	Biochemical Assay Reagents
Dap-NE hydrochloride (GMP) is Dap-NE hydrochloride (HY-78932A) produced by using GMP guidelines. Dap-NE hydrochloride is an intermediate used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W000423G

DBCO-amine (GMP)	Biochemical Assay Reagents
DBCO-amine GMP is a GMP grade DBCO-amine (HY-W000423). DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-amine is a click chemistry reagent, itcontains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-163789

Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide	Biochemical Assay Reagents
Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .

HY-16700G

PNU-159682 (GMP)	Biochemical Assay Reagents
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

HY-42972G

DBCO-acid (GMP)

Biochemical Assay Reagents

HY-131990G

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)	Biochemical Assay Reagents
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-131990). MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-45672G

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)	Biochemical Assay Reagents
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-45672). Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate .

Cat. No.	Product Name	Target	Research Area

HY-P4192

Fomc-Gly-Gly-Phe-Gly-OH	ADC Linker	Cancer
Fomc-Gly-Gly-Phe-Gly-OH (compound D5) can be used as an intermediate in the synthesis of ADC dual-drug-linker. Fomc-Gly-Gly-Phe-Gly-OH synthetic intermediate GGFGE further forms an important ADC dual-drug link assembly unit .

Cat. No.	Product Name	Target	Research Area

HY-P99229

Upifitamab 1 Publications Verification	ADC Antibody	Cancer
Upifitamab is an ADC Antibody (a naked antibody of upifitamab rilsodotin), which can be used for antibody-coupled agent (ADC) synthesis. Upifitamab rilsodotin is an *ADC* targeting NaPi2b and is used in ovarian cancer research, particularly in platinum-resistant recurrent ovarian cancer .

HY-P99684

Laprituximab J2898A	EGFR	Cancer
Laprituximab (J2898A) is a humanized IgG1 anti-EGFR antibody that can be used for the synthesis of ADC IMGN289 .

HY-145626

Ozuriftamab BA302	ADC Antibody	Cancer
Ozuriftamab is a naked human IgG1 kappa antibody of receptor tyrosine kinase-like orphan receptor 2 ROR2, can be used to synthesis *ADC* .

HY-P99453

Azintuxizumab	ADC Antibody	Cancer
Azintuxizumab is an anti-SLAMF7 human IgG4κ monoclonal antibody. Azintuxizumab can be used in the synthesis of antibody-drug conjugate (ADC), Azintuxizumab vedotin .

HY-P9980

Belantamab GSK2857914	TNF Receptor ADC Antibody	Cancer
Belantamab (GSK2857914) is a humanised IgG1 anti-BCMA (TNFRSF17) monoclonal antibody. Belantamab can be used in the synthesis of antibody-drug conjugate (ADC), Belantamab mafodotin .

HY-P99712

Lonigutamab hz208F2-4	IGF-1R ADC Antibody	Cancer
Lonigutamab (hz208F2-4) is a humanized anti-IGF-1R monoclonal antibody that can be used for the synthesis of antibody–agent conjugates (ADC) .

HY-P99854

Disitamab RC48-0	EGFR ADC Antibody	Cancer
Disitamab (RC48-0) is a humanized monoclonal antibody targeting HER2. Disitamab can be used in the synthesis of antibody-drug conjugates (ADCs), Disitamab vedotin (Disitamab vedotin (HY-P9985)) .

HY-P99352

Anetumab Anti-MSLN Antibody	Mesothelin	Cancer
Anetumab (Anti-MSLN Antibody) is an anti-mesothelin (MSLN) antibody. MSLN is a tumor-associated antigen. Anetumab can be used to synthesis Anetumab ravtansine, a MSLN-targeting antibody-drug conjugate (ADC). Anetumab can be used for the research of malignant tumor .

HY-P99043

Rovalpituzumab	Notch	Cancer
Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine . Rovalpituzumab has activity against small cell lung cancer (SCLC) .

HY-P99230

Pinatuzumab	Integrin CD22	Cancer
Pinatuzumab is a CD22 monoclonal antibody. Pinatuzumab targets the cell-surface antigen CD22. Pinatuzumab can be used for synthesis of antibody agent conjugates (ADCs) to research several diseases including non-Hodgkin lymphoma (NHL) .

HY-P99733

Mipasetamab	ADC Antibody TAM Receptor	Cancer
Mipasetamab is an IgG1κ antibody targeting to AXL, a tyrosine kinase receptor and an TAM Receptor. Mipasetamab involves in synthesis of ADCT-601 (Mipasetamab uzoptirine), an AXL-targeted antibody-drug conjugate (ADC). ADCT-601 has anti-tumor activity .

HY-P99233

Camidanlumab HuMax-TAC	Interleukin Related	Cancer
Camidanlumab (HuMax-TAC) is a CD25 monoclonal antibody. Camidanlumab targets the cell-surface antigen CD25, which is over-expressed on a variety of hematological tumors and shows limited expression on normal tissues. Camidanlumab can be used for synthesis of antibody agent conjugates (ADCs) to research several diseases including lymphoma and leukemia .

HY-P99971

Gemtuzumab	ADC Antibody	Cancer
Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen, which present on leukemic myeloblasts of acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate *(ADC)*, Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia .

HY-P99045

Sacituzumab	ADC Antibody TROP2	Cancer
Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab is used for the synthesis of antibody-drug conjugates (ADC) drugs. Antibody-drug conjugates with sacituzumab (sacituzumab govitecan) (HY-132254) targeting TROP-2 have been approved for the field of triple-negative breast cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W034595

Eicosanedioic acid	Microorganisms Source classification	ADC Linker PROTAC Linkers
Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

HY-W034918

Docosanedioic acid	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	ADC Linker PROTAC Linkers
Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-P9980

Belantamab GSK2857914	Classification of Application Fields Disease Research Fields Cancer	TNF Receptor ADC Antibody
Belantamab (GSK2857914) is a humanised IgG1 anti-BCMA (TNFRSF17) monoclonal antibody. Belantamab can be used in the synthesis of antibody-drug conjugate (ADC), Belantamab mafodotin .

HY-P99854

Disitamab RC48-0	Classification of Application Fields Disease Research Fields Cancer	EGFR ADC Antibody
Disitamab (RC48-0) is a humanized monoclonal antibody targeting HER2. Disitamab can be used in the synthesis of antibody-drug conjugates (ADCs), Disitamab vedotin (Disitamab vedotin (HY-P9985)) .

HY-P99352

Anetumab Anti-MSLN Antibody	Classification of Application Fields Disease Research Fields Cancer	Mesothelin
Anetumab (Anti-MSLN Antibody) is an anti-mesothelin (MSLN) antibody. MSLN is a tumor-associated antigen. Anetumab can be used to synthesis Anetumab ravtansine, a MSLN-targeting antibody-drug conjugate (ADC). Anetumab can be used for the research of malignant tumor .

HY-P99043

Rovalpituzumab	Classification of Application Fields Disease Research Fields Cancer	Notch
Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine . Rovalpituzumab has activity against small cell lung cancer (SCLC) .

HY-P99971

Gemtuzumab	Classification of Application Fields Disease Research Fields Cancer	ADC Antibody
Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen, which present on leukemic myeloblasts of acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate *(ADC)*, Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia .

HY-P99045

Sacituzumab	Classification of Application Fields Disease Research Fields Cancer	ADC Antibody TROP2
Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab is used for the synthesis of antibody-drug conjugates (ADC) drugs. Antibody-drug conjugates with sacituzumab (sacituzumab govitecan) (HY-132254) targeting TROP-2 have been approved for the field of triple-negative breast cancer .

HY-131081

γ-Amanitin	Structural Classification Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Source classification Disease Research Fields Cancer	DNA/RNA Synthesis ADC Cytotoxin
γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC₅₀ of 163.1 ng/mL .

HY-12457

Rachelmycin CC-1065; NSC 298223	Structural Classification Classification of Application Fields Source classification Disease Research Other Antibiotics Infection Monophenols Microorganisms Antibiotics Phenols Anticancer Disease Research Fields Cancer	Antibiotic DNA/RNA Synthesis
Rachelmycin (CC-1065) is an antitumor antibiotic and a DNA-alkylating agent. Rachelmycin has cytotoxic potency that can be used as a cytotoxin to synthesis ADC. Rachelmycin effectively inhibits DNA synthesis. Rachelmycin can be used for cancer and infection research .

Cat. No.	Product Name	Chemical Structure

HY-156756S

7-Hydroxymethyl-10,11-MDCPT-d5
7-Hydroxymethyl-10,11-MDCPT-d₅ is deuterium labeled 7-Hydroxymethyl-10,11-MDCPT, which is a is a payload that can be used for *ADC* synthesis .

HY-161022S1

FL118-C3-O-C-amide-C-NH2-d5 formate
FL118-C3-O-C-amide-C-NH2-d5 formate is a deuterium labeled FL118-C3-O-C-amide-C-NH2 formate. FL118-C3-O-C-amide-C-NH2 formate is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-114816S

N-butyryl-L-Homoserine lactone-d5

N-butyryl-L-Homoserine lactone-d₅ is the deuterium labeled N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3].

HY-145397S

(4-NH2)-Exatecan-d5
(4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan . (4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs) .

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