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Tumor Growth Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	BRK (1) EGFR (35) FGFR (9) IGF-1R (3) Nuclear Hormone Receptor 4A/NR4A (1) PDGFR (5) TGF-beta/Smad (1) TGF-β Receptor (5) TNF Receptor (5) VEGFR (11) 5 alpha Reductase (2) ADC Cytotoxin (9) Adenosine Receptor (1) Adrenergic Receptor (3) Akt (20) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (1) Amino Acid Derivatives (1) AMPK (2) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (9) Androgen Receptor (13) Antibiotic (4) Antifolate (3) AP-1 (2) Apoptosis (171) Arginase (1) Aryl Hydrocarbon Receptor (8) ASCT (2) Atg8/LC3 (2) Aurora Kinase (8) Autophagy (43) Bacterial (18) Bcl-2 Family (6) BCL6 (1) Bcr-Abl (5) BCRP (1) Biochemical Assay Reagents (3) Btk (1) c-Fms (2) c-Kit (1) c-Met/HGFR (17) c-Myc (6) Calcium Channel (1) Carbonic Anhydrase (4) Caspase (9) CD73 (3) CDK (23) Checkpoint Kinase (Chk) (1) Cholecystokinin Receptor (1) COMT (3) COX (9) CRM1 (1) CXCR (1) Cyclin G-associated Kinase (GAK) (1) Cyclophilin (1) Cytochrome P450 (5) Dengue virus (1) Deubiquitinase (3) Dihydrofolate reductase (DHFR) (3) Dihydroorotate Dehydrogenase (2) DNA Methyltransferase (1) DNA-PK (2) DNA/RNA Synthesis (12) Dopamine Receptor (1) Drug Metabolite (3) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (3) Endogenous Metabolite (17) Epigenetic Reader Domain (11) ERK (10) Estrogen Receptor/ERR (5) Eukaryotic Initiation Factor (eIF) (1) FAK (7) Farnesyl Transferase (1) Fatty Acid Synthase (FASN) (2) Ferroptosis (1) Flavivirus (1) FLT3 (11) Fluorescent Dye (3) Fungal (6) FXR (2) G-quadruplex (2) GABA Receptor (1) GCGR (1) Gli (1) Glycosyltransferase (1) GnRH Receptor (1) GSK-3 (1) HBV (3) HDAC (16) Hexokinase (2) HIF/HIF Prolyl-Hydroxylase (11) Histone Acetyltransferase (2) Histone Methyltransferase (13) HIV (3) HPV (2) HSP (10) HSV (2) HuR (1) IAP (2) IFNAR (2) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (4) Insulin Receptor (2) Integrin (5) Interleukin Related (2) IRE1 (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (9) JAK (4) JNK (1) Keap1-Nrf2 (1) Lactate Dehydrogenase (1) Leukotriene Receptor (1) LXR (1) MAP4K (2) MAPKAPK2 (MK2) (1) MDM-2/p53 (8) MEK (4) MetAP (1) Methionine Adenosyltransferase (MAT) (2) METTL3 (3) mGluR (1) Microtubule/Tubulin (23) Mitochondrial Metabolism (4) MMP (7) MNK (1) Molecular Glues (2) Monoamine Oxidase (2) Monocarboxylate Transporter (1) mTOR (8) nAChR (1) NAMPT (1) Necroptosis (4) NF-κB (13) NO Synthase (4) Notch (4) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (1) Organoid (2) Oxidative Phosphorylation (2) P-glycoprotein (1) P2Y Receptor (1) p38 MAPK (2) p62 (2) PAK (2) Parasite (5) PARP (8) PD-1/PD-L1 (12) PDHK (1) PDI (1) PDK-1 (3) PERK (2) PGE synthase (2) Phosphatase (7) Phosphodiesterase (PDE) (2) Phosphoglycerate Dehydrogenase (PHGDH) (1) Phospholipase (2) PI3K (15) PIKfyve (1) Pim (1) PKA (2) PKC (6) PKD (1) Polo-like Kinase (PLK) (3) Poly(ADP-ribose) Glycohydrolase (PARG) (1) Potassium Channel (1) Progesterone Receptor (6) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (1) PROTACs (21) Proteasome (1) Protein Arginine Deiminase (2) Proton Pump (9) PSMA (1) Pyroptosis (1) Raf (1) Ras (16) Reactive Oxygen Species (11) Reverse Transcriptase (2) Ribosomal S6 Kinase (RSK) (3) ROCK (2) ROS Kinase (9) Ser/Thr Protease (3) SGK (2) SHP2 (3) Sirtuin (8) Smo (2) Sodium Channel (2) Src (2) STAT (12) STING (1) Survivin (2) TAM Receptor (4) Telomerase (1) Thymidylate Synthase (1) Tie (1) Toll-like Receptor (TLR) (4) Topoisomerase (19) Trk Receptor (6) TRP Channel (1) TrxR (1) Tryptophan Hydroxylase (1) Tyrosinase (1) VD/VDR (1) Wnt (3) Xanthine Oxidase (1) YAP (6) α-synuclein (1) β-catenin (1) γ-secretase (1)
By Research Areas:	Cancer (680) Cardiovascular Disease (12) Endocrinology (6) Infection (33) Inflammation/Immunology (60) Metabolic Disease (20) Neurological Disease (27)
Click Chemistry:	Azide (3) Alkynes (5)
Oligonucleotides:	Aptamers (5) CpG ODNs (2) Phospholipids (1) Antisense Oligonucleotides (5) Cholesterol (1)

684

Inhibitors & Agonists

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Targets Recommended: TNF Receptor FGFR BRK GHR VEGFR TGF-beta/Smad PDGFR TGF-β Receptor GHSR EGFR IGF-1R Nuclear Hormone Receptor 4A/NR4A

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144707

AK-778-XXMU	Apoptosis	Cancer
AK-778-XXMU is a potent inhibitor of DNA Binding 2 (ID2) antagonist with a K_D of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and more importantly, slow down the tumor growth .

HY-N0438

Pimpinellin 1 Publications Verification	Apoptosis	Cancer
Pimpinellin is a constituent of Cyrtomium fortumei (J.). Pimpinellin inhibits the growth of tumor cells via the induction of tumor cell apoptosis .

HY-14754

Salirasib 5+ Cited Publications S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS	Ras Autophagy	Cancer
Salirasib is a Ras inhibitor that inhibits specifically both oncogenically activated Ras and growth factor receptor-mediated Ras activation, resulting in the inhibition of Ras-dependent tumor growth.

HY-161412

STR-V-53	HDAC	Cancer
STR-V-53 is an HDAC inhibitor (IC₅₀ in nM).STR-V-53 increases histone acetylation in tumor cells by inhibiting the activity of these enzymes, which in turn regulates gene expression.STR-V-53 inhibits tumor growth, and induces apoptosis .

HY-162128

Antitumor agent-130	Histone Acetyltransferase	Cancer
Antitumor agent-130 (Compound 7b) is a p300 histone acetyltransferases (HAT) inhibitor with an IC₅₀ of 1.51 μM. Antitumor agent-130 combinates with doxorubicin (HY-15142A) can significantly inhibit tumor growth and invasion in vitro and in vivo .

HY-145428

BT-GSI	Notch γ-secretase	Cancer
BT-GSI is a γ-secretase inhibitor (GSI) and a bone-targeted Notch inhibitor. BT-GSI has dual anti-myeloma and anti-resorptive properties, which can be used for the research of multiple myeloma and associated bone disease. BT-GSI inhibits tumor growth and osteolytic disease progression .

HY-119616

Phenamet	Apoptosis	Cancer
Phenamet is an anti-tumor agent that can inhibit tumor growth and slow the progression of cancer. Phenamet prevents the reproduction of tumor cells by interfering with the growth and division of cancer cells. In addition, Phenamet can induce apoptosis in cancer cells, thereby eliminating tumor cells.

HY-19459A

Ocaphane free acid AT-581 free acid	Others	Cancer
Ocaphane (free acid) is an antitumor agent that inhibits tumor growth in the Ehrlich tumor mouse model .

HY-19471

(rac)-ZK-304709	Others	Cancer
(rac)-ZK-304709 is an isomer of ZK-304709. It is a first-in-class oral multi-target tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (Cdks), vascular endothelial growth factor receptor kinases (VEGF-RTKs), and platelet-derived growth factor receptor kinase β (PDGF-RTKβ). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. It directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1α. In an orthotopic BON tumor model, (rac)-ZK-304709 reduced primary tumor growth by 80% and reduced tumor microvascular density. These results suggest that (rac)-ZK-304709 can effectively control tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may be a potential agent for the treatment of NET.

HY-120187

DDCPPB-Glu	Others	Others
DDCPPB-Glu (compound 3a) is a compound with anti-tumor activity, which has the activity of inhibiting tumor cell growth and prolonging survival. DDCPPB-Glu has growth inhibition effect on various tumor cell lines, can increase the survival time of leukemia mice, and has inhibitory effect on tumors such as colon cancer and lung cancer.

HY-U00002A

ZD-4190 hydrochloride	Others	Cancer
ZD-4190 hydrochloride is a potent VEGFR inhibitor with anti-tumor activity. ZD-4190 hydrochloride can delay the growth of MDA-MB-435 tumors by inhibiting tumor cell proliferation and angiogenesis .

HY-122703

BETi-211	Epigenetic Reader Domain	Cancer
BETi-211 is an orally active BET inhibitor (K_i: <1 nM). BETi-211 inhibits growth of triple-negative breast cancers (TNBC) cell lines with IC₅₀ < 1 μM. BETi-211 degrades BET proteins and suppress tumor growth in xenograft breast tumors .

HY-42484

ER-076349	Microtubule/Tubulin	Cancer
ER-076349 is an inhibitor of tubulin polymerization, induces G2-M cell cycle arrest, and disrupts mitotic spindles. ER-076349 inhibits cancer cell growth, and inhibits tumor growth in several human tumor xenografts. ER-076349 is an analog of Halichondrin B .

HY-143510

RMC-4627	mTOR	Cancer
RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.

HY-P2028

BIM 21009	GnRH Receptor	Cancer
BIM 21009 is a LHRH and GnRH receptor antagonist. BIM 21009 inhibits tumor growth .

HY-N7223

Lappaol F	YAP Apoptosis	Cancer
Lappaol F, a lignin, is an anticancer agent. Lappaol F inhibits YAP<、b> mRNA and protein level. Lappaol F inhibits tumor cell growth by inducing cell cycle arrest. Lappaol F induces cancer cell apoptosis, and inhibits tumor growth. Lappaol F can be isolated from Arctium lappa Linne (Asteraceae) .

HY-142965

HDAC-IN-28	HDAC	Cancer
HDAC-IN-28, a novel HDAC inhibitor, shows potent activities against tumor growth and metastasis

HY-19601

Carzelesin U 80244	Others	Cancer
Carzelesin is a cyclopropylpyrroloindole precursor molecule and effectively inhibits tumor growth. Carzelesin may be used in cancer research.

HY-149694

Aurora kinase inhibitor-12	Aurora Kinase	Cancer
Aurora Kinase Inhibitor-12 (Compound 1a ) is the inhibitor of aurora kinase which is a key enzyme that is implicated in tumor growth .

HY-N0183

Formononetin 10+ Cited Publications Biochanin B; Flavosil; Formononetol	FGFR Apoptosis	Cardiovascular Disease Cancer
Formononetin is a potent FGFR2 inhibitor with an IC₅₀ of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth .

HY-103471

Y11	FAK	Cancer
Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397 and decreases tumor growth .

HY-160768

OTUB2-IN-1	Deubiquitinase	Inflammation/Immunology Cancer
OTUB2-IN-1, a specific inhibitor of OTUB2 (K_D: ~12 μM), reduces PD-L1 protein expression in tumor cells and inhibits tumor growth by promoting robust intra-tumor infiltration of cytotoxic T lymphocytes (CTL) .

HY-13648

Incyclinide 5+ Cited Publications CMT-3; COL-3	MMP	Cancer
Incyclinide (CMT-3, COL-3) is a matrix metalloproteinase (MMP) inhibitor and inhibiting angiogenesis, tumor growth and invasion, and metastasis.

HY-107008

SW 71425	Others	Cancer
SW 71425 inhibits cell growth against breast, colon, non-small cell lung, and ovarian tumors. .

HY-117515

YLT205	Apoptosis	Cancer
YLT205 is an anticancer agent and induces cell apoptosis. YLT205 inhibits tumor growth in vivo and in vitro .

HY-18310

NIBR-17	PI3K	Cancer
NIBR-17 is a pan-class I PI3K inhibitor with suitable pharmacokinetic properties and inhibits tumor growth .

HY-163644

VT-105	Others	Cancer
VT-105 is a potent and selective TEAD autopalmitoylation inhibitor that inhibits proliferation and tumor growth in NF2-deficient mesothelioma.

HY-14815

Fosbretabulin Combretastatin A4 phosphate	Apoptosis Microtubule/Tubulin	Cancer
Fosbretabulin (Combretastatin A4 phosphate) is a vascular disruptor with antitumor activity against atypical thyroid carcinoma (ATC) cell lines and xenografts. Fosbretabulin inhibits tumor growth by inhibiting microtubule polymerization, inducing apoptosis, and suppressing angiogenesis in tumors .

HY-P5107

Low molecular weight protamine LMWP	VEGFR	Cancer
Low molecular weight protamine is a cell-penetrating peptide with vascular endothelial growth factor (VEGF) inhibitory activity. Low molecular weight protamine can inhibit tumor growth and is used in cancer research .

HY-12710

Rauwolscine α-Yohimbine; Corynanthidine; Isoyohimbine	Adrenergic Receptor	Cancer
Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis .

HY-W100403

Choline tosylate Choline p-toluenesulfonate	Phospholipase	Cancer
Choline tosylate is a nucleophilic compound that inhibits phospholipase A2 and phospholipase C. Choline tosylate inhibits tumor growth in mice by inhibiting the formation of diacylglycerol (DAG) .

HY-132980

Olomorasib KRAS G12C Inhibitor 19	Ras	Cancer
Olomorasib is a potent inhibitor of KRAS G12C. Olomorasib significantly inhibits tumor growth (extracted from patent WO2021118877A1) .

HY-156673

m-Se3	c-Myc	Cancer
m-Se3 is a potent and selective c-MYC transcription inhibitor that can inhibit tumor growth and has anti-cancer activity .

HY-136538

LQZ-7I	Survivin	Cancer
LQZ-7I is a survivin-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors .

HY-119823

PGP-4008	P-glycoprotein	Cancer
PGP-4008 is a specific P-glycoprotein (Pgp) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin .

HY-168022

CAM2602	Others	Cancer
CAM2602 is an Aurora A-TPX2 interaction inhibitor that has a binding affinity of 19 nM to Aurora A. CAM2602 can inhibit the growth of pancreatic cancer cells. In solid tumor transplant models, CAM2602 can increase the proportion of PH3 positive cells while reducing the proportion of P-Thr288 Aurora A positive cells, thereby inhibiting tumor growth .

HY-P0073

Tyr-Gly-Gly-Phe-Met-OH 2 Publications Verification Met-Enkephalin; Methionine enkephalin; Metenkefalin	Opioid Receptor	Neurological Disease Cancer
Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.

HY-P9969

Matuzumab EMD 72000	EGFR	Cancer
Matuzumab (EMD 72000) is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth .

HY-127118

Pteropterin Pteroyltriglutamic	Others	Cancer
Pteropterin (Pteroyltriglutamic) is an active form of folate. Pteropterin shows inhibiting effect on tumor growth and has broad anticancer activity .

HY-127118A

Pteropterin monohydrate Pteroyltriglutamic monohydrate	Others	Cancer
Pteropterin (Pteroyltriglutamic) monohydrate is an active form of folate. Pteropterin monohydrate shows inhibiting effect on tumor growth and has broad anticancer activity .

HY-155523

Tubulin/HDAC-IN-2	Microtubule/Tubulin HDAC Apoptosis	Cancer
Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor of Tubulin and HDAC, with an IC₅₀ of 0.403 μM, 0.591μM, 3.552μM, 0.459μM for HDAC1/2/3/6. Tubulin/HDAC-IN-2 blocks cell cycle arrest at G2 phase, induces cell *apoptosis. Tubulin/HDAC-IN-2 inhibits* the growth of hematoma and solid tumor cells, reduces tumor metastasis, and also inhibits tumor growth in a liver tumor allograft mouse model .**

HY-12444

Y15 15+ Cited Publications FAK Inhibitor 14	FAK	Cancer
Y15 is a potent and specific inhibitor of focal adhesion kinase (FAK) that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth.

HY-107720

ARL 17477	NO Synthase	Cancer
ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers .

HY-157122

VJDT 1 Publications Verification	Others	Cancer
VJDT is a TREM1 small molecule inhibitor that effectively blocks TREM1 signaling. VJDT inhibits tumor growth and can be used in cancer research .

HY-161179

TRK-IN-27	Trk Receptor	Cancer
TRK-IN-27 (Compound 14q) is a potent TRK inhibitor with good kinase selectivity. TRK-IN-27 effectively inhibits tumor growth .

HY-10338A

Foretinib phosphate	c-Met/HGFR VEGFR	Cancer
Foretinib phosphate is an orally bioavailable small molecule with potential anti-tumor activity. Foretinib phosphate can selectively inhibit hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), thereby potentially inhibiting tumor angiogenesis, tumor cell proliferation and metastasis. Foretinib phosphate shows different anti-cancer activity from cabozantinib in lung cancer cells and has stronger inhibitory effects on targets such as MEK1/2, FER and AURKB .

HY-121259

Doxorubicinol Adriamycinol; DXR-OL	Endogenous Metabolite	Cardiovascular Disease
Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity.

HY-N11669

Demycarosyl-3D-β-D-digitoxosylmithramycin SK	DNA/RNA Synthesis	Cancer
Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analog with good anti-tumor activity, which can prevent the proliferation and growth of tumor cells by binding and inhibiting DNA-binding proteins .

HY-118371

Arginase inhibitor 2	Arginase	Cancer
Arginase inhibitor 2 is an Arginase inhibitor (Page 130 in reference patent). Arginase inhibitor 2 synergizes with adoptively transferred antigen- specific T cells to inhibit tumor growth .

HY-162091

Topoisomerase I inhibitor 13	Topoisomerase	Cancer
Topoisomerase I inhibitor 13 (Compound G11) is a Topo I inhibitor that inhibits cancer cell proliferation. Topoisomerase I inhibitor 13 significantly inhibits tumor growth in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0438

Pimpinellin 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Ericameria laricifolia (A.Gray) Shinners Plants Disease Research Fields Cancer	Apoptosis
Pimpinellin is a constituent of Cyrtomium fortumei (J.). Pimpinellin inhibits the growth of tumor cells via the induction of tumor cell apoptosis .

HY-N0183

Formononetin 10+ Cited Publications Biochanin B; Flavosil; Formononetol	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Flavonoids other families Leguminosae Sunscreen Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones	FGFR Apoptosis
Formononetin is a potent FGFR2 inhibitor with an IC₅₀ of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth .

HY-12710

Rauwolscine α-Yohimbine; Corynanthidine; Isoyohimbine	Apocynaceae Rauvolfia tetraphylla Linn. Alkaloids Structural Classification Source classification Plants Indole Alkaloids	Adrenergic Receptor
Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis .

HY-P9969

Matuzumab EMD 72000	Classification of Application Fields Disease Research Fields Cancer	EGFR
Matuzumab (EMD 72000) is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth .

HY-N7223

Lappaol F	Structural Classification Source classification Lignans Phenylpropanoids Plants Compositae Gueldenstaedtia verna (Georgi) Boriss.	YAP Apoptosis
Lappaol F, a lignin, is an anticancer agent. Lappaol F inhibits YAP<、b> mRNA and protein level. Lappaol F inhibits tumor cell growth by inducing cell cycle arrest. Lappaol F induces cancer cell apoptosis, and inhibits tumor growth. Lappaol F can be isolated from Arctium lappa Linne (Asteraceae) .

HY-121259

Doxorubicinol Adriamycinol; DXR-OL	Cardiovascular Disease Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity.

HY-N11669

Demycarosyl-3D-β-D-digitoxosylmithramycin SK	Structural Classification Natural Products Microorganisms Source classification	DNA/RNA Synthesis
Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analog with good anti-tumor activity, which can prevent the proliferation and growth of tumor cells by binding and inhibiting DNA-binding proteins .

HY-152120

(±)-Aiphanol Aiphanol	Structural Classification Source classification Phenols Polyphenols Arecaceae Plants Aiphanes aculeata Willd	COX VEGFR
(±)-Aiphanol is a newly discovered stilbenolignan analog. (±)-Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of COX-1 and COX-2. The inhibitory effect on COX-1 (IC₅₀ = 1.9 μM) is particularly strong, while the effect on COX-2 (IC₅₀= 9.9 μM) is relatively weak .(±)-Aiphanol effectively inhibits VEGFR2 (IC₅₀=0.92 µM). (±)-Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (±)-Aiphanol is orally active .

HY-N11638

Ganoderic acid R	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Apoptosis
Ganoderic acid R is a potent anticancer agent. Ganoderic acid R inhibits the growth by inducing apoptosis on tumor cell line. Ganoderic acid R possesses significant cytotoxicity on a multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and a sensitive tumor cell line (KB-A-1) .

HY-119739

Skyrin	Ventilago leiocarpa Benth. Quinones Structural Classification Anthraquinones Source classification Plants Rhamnaceae	GCGR
Skyrin is an anthraquinone compound that can be isolated from almond fruit. Skyrin is a receptor-selective glucagon antagonist. Skyrin can inhibit the growth of tumor cells .

HY-N0462

Corilagin 4 Publications Verification	Phyllanthus urinaria Linn. Infection Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR) Reverse Transcriptase Bacterial Apoptosis Autophagy
Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular carcinoma and ovarian cancer model. Corilagin shows low toxicity to normal cells and tissues .

HY-P99217

Rilotumumab AMG 102	Classification of Application Fields Disease Research Fields Cancer	c-Met/HGFR
Rilotumumab (AMG 102) is an anti-HGF (anti-hepatocyte growth factor) monoclonal antibody, inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research .

HY-N11096

Sinococuline	Structural Classification Alkaloids Piperidine Alkaloids Source classification Plants Menispermaceae Stephania japonica (Thunb.) Miers	Flavivirus Dengue virus
Sinococuline is a potent anti-dengue agent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor .

HY-138071

8α-Tigloyloxyhirsutinolide 13-O-acetate 8αTGH	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Dalbergia frutescens (Vell.) Britton	STAT Pyroptosis Apoptosis Reactive Oxygen Species c-Myc Bcl-2 Family TrxR
8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, apoptosis in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo .

HY-N0247

Saikosaponin B1	Structural Classification Classification of Application Fields Source classification Umbelliferae Plants Disease Research Fields Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray Cancer	Smo
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting SMO .

HY-N0183R

Formononetin (Standard)	Structural Classification Flavonoids other families Leguminosae Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Glycyrrhiza uralensis Fisch. Isoflavones	FGFR Apoptosis
Formononetin (Standard) is the analytical standard of Formononetin. This product is intended for research and analytical applications. Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth .

HY-P99291

Etaracizumab LM 609; MEDI 523; Anti-αvβ3 Integrin Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	Integrin
Etaracizumab (LM 609) is an α_vβ₃ integrin IgG1 monoclonal antibody. Etaracizumab inhibits angiogenesis and melanoma tumor growth. Etaracizumab can be used to research anticancer .

HY-N6644

Crocin III	Structural Classification Classification of Application Fields Terpenoids Source classification Diterpenoids Lridaceae Plants Crocus sativus L. Inflammation/Immunology Disease Research Fields	Others
Crocin III is a crocetin from saffron (Crocus sutivus L.). Crocetins inhibit cell growth of tumor cells and has anti-inflammatory activity. Crocins serve as spices and coloring agents .

HY-118893

Asukamycin	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial Fungal Molecular Glues
Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines .

HY-131257

Gefitinib impurity 1	Classification of Application Fields Disease Research Fields Cancer	Drug Metabolite
Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity .

HY-133779

Gefitinib impurity 5	Classification of Application Fields Disease Research Fields Cancer	Drug Metabolite
Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity .

HY-120241

Reticulol K 251-1	Structural Classification Microorganisms Source classification Phenols Polyphenols	Phosphodiesterase (PDE)
Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma .

HY-P99849

Depatuxizumab ABT-806	Classification of Application Fields Disease Research Fields Cancer	EGFR
Depatuxizumab is a brain-penetrant and humanized tumor-specific anti EGFR monoclonal antibody. Depatuxizumab inhibits the growth of xenograft models of mutant EGFRvIII and wild-type EGFR. Depatuxizumab can be used for research on cancer .

HY-122341

Thrazarine FR 900840	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Antibiotic
Thrazarine (FR 900840) is an oncology antibiotic that can be produced by Streptomyces coerulescens MH802-fF5. Thrazarine directly inhibits DNA synthesis and tumor cell growth. Thrazarine can specifically induce lysis of tumor cells co-cultured with non-activated macrophages. Thrazarine is used in cancer research .

HY-N0462R

Corilagin (Standard)	Phyllanthus urinaria Linn. Structural Classification Source classification Phenols Polyphenols Euphorbiaceae Plants	Toll-like Receptor (TLR) Reverse Transcriptase Bacterial Apoptosis Autophagy
Corilagin (Standard) is the analytical standard of Corilagin. This product is intended for research and analytical applications. Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular carcinoma and ovarian cancer model. Corilagin shows low toxicity to normal cells and tissues .

HY-N6601

Pomolic acid Randialic acid A	Triterpenes Structural Classification Euscaphis japonica other families Staphyleaceae Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from?Euscaphis japonica?(Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC) .

HY-40136

cis-4-Hydroxy-L-proline	Structural Classification Microorganisms Classification of Application Fields Santalum album Linn. Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields Santalaceae	Endogenous Metabolite
cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors .

HY-Y0892

4-Hydroxybenzyl alcohol 1 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Monophenols Microorganisms Gastrodia elata Bl. Orchidaceae Phenols Inflammation/Immunology Disease Research Fields	Apoptosis Endogenous Metabolite
4-Hydroxybenzyl alcohol is a phenolic compound widely distributed in various kinds of plants. Anti-inflammatory, anti-oxidant, anti-nociceptive activity. Neuroprotective effect. Inhibitor of tumor angiogenesis and growth .

HY-N1381

Periplocin 3 Publications Verification	Structural Classification Classification of Application Fields Source classification Asclepiadaceae Plants Periploca sepium Bunge Inflammation/Immunology Disease Research Fields Steroids	Apoptosis
Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

HY-100663

Gefitinib impurity 2	Classification of Application Fields Disease Research Fields Cancer	EGFR
Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity .

HY-N6772

Cytochalasin E	Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Autophagy
Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation .

HY-N5058

Dehydroeffusol	Structural Classification Natural Products Juncus effusus Linn. Juncaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity .

HY-113544

Physapubenolide	Structural Classification Source classification Physalis angulata L. Solanaceae Plants Steroids	Others
Physapubenolide is a cytotoxic steroidal compound isolated from Physalis, which has the activity of increasing intracellular ROS levels by downregulating TIGAR, thereby inducing apoptosis and autophagosome formation in human breast cancer cells, ultimately inhibiting tumor growth.

HY-N12044

Asparanin A	Structural Classification Polysaccharides Liliaceae Source classification Plants Saccharides Asparagus officinalis L.	Apoptosis
Asparanin A is an apoptosis inducer with anticancer activity. Asparanin A induces cell cycle arrest in the G0/G1 phase through mitochondria and PI3K/AKT signaling pathways, inhibiting cancer cell growth. Asparanin A also demonstrated in vivo efficacy in a mouse xenograft model of Ishikawa endometrial carcinoma, significantly inhibiting tumor growth .

HY-13906

Largazole (+)-Largazole	Structural Classification Natural Products Microorganisms Source classification	Others
Largazole ((+)-Largazole) is a potent and selective histone deacetylase (HDAC) inhibitor with antiproliferative activity. Largazole is able to modulate gene expression and affect cell growth and differentiation. Largazole has also shown potential application value in anti-tumor suppression .

HY-P99270

Tigatuzumab CS-1008; Anti-Human TRAIL-R2 Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	Apoptosis
Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer .

HY-N2040

(20R)-Protopanaxadiol	Panax ginseng C. A. Meyer Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Bacterial
(20R)-Protopanaxadiol is a triterpenoid saponin metabolite of 20(R)-ginsenoside Rg3 in black ginseng. (20R)-Protopanaxadiol exhibits anti-tumor activity and cytotoxicity, and potently inhibits the growth of Helicobacter pylori .

HY-N12437

Marsdenoside B	Structural Classification Araceae Cardiacglycosides Source classification Plants Alocasia cucullata (Lour.) Schott Steroids	Others
Marsdenoside B (compound 8) is a Marsdenoside isolated from Alocasia genus. Marsdenoside B inhibits the growth of tumor cell lines MGC-803 and HT-29 with IC₅₀s of 25.6 μg/mL and 32.4 μg/mL, respectively.

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	Classification of Application Fields Disease Research Fields Cancer	TNF Receptor
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-D0226

Quinizarin 1,4-Dihydroxyanthraquinone	Infection Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Solanaceae Plants Disease Research Fields Rhizophora mucronata Lam	DNA/RNA Synthesis Fungal
Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (K_d=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth .

HY-N8228

17-Hydroxyneomatrine	Structural Classification Alkaloids Leguminosae Other Alkaloids Source classification Plants Sophora flavescens Aiton	Bacterial
17-Hydroxyneomatrine, extracted from Sophora flavescens, can well inhibit the growth of human cervical carcinoma Hela cells, has the wide-range antibacterial, anti-allergy, anti-tumor, anti-arrhythmia, swelling-subsiding diuresis, immunizing, and biological regulation functions .

HY-B0150

Nicotinamide Maximum Cited Publications 48 Publications Verification Niacinamide; Nicotinic acid amide	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	Organoid Endogenous Metabolite Sirtuin HBV
Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC₅₀: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD₊, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity .

HY-B0150A

Nicotinamide Hydrochloride Niacinamide Hydrochloride; Nicotinic acid amide Hydrochloride	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	Sirtuin Endogenous Metabolite HBV
Nicotinamide Hydrochloride is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC₅₀: 2 μM). Nicotinamide Hydrochloride also inhibits SIRT1. Nicotinamide Hydrochloride increases cellular NAD₊, ATP, ROS levels. Nicotinamide Hydrochloride inhibits tumor growth and improves survival. Nicotinamide Hydrochloride also has anti-HBV activity .

HY-N1480

(-)-Fucose 6-Desoxygalactose; L-(-)-Fucose; L-Galactomethylose	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Parasite
(-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth .

HY-W005288

4-Vinylphenol	Monophenols Microorganisms Classification of Application Fields Source classification Rubiaceae Phenols Plants Endogenous metabolite Disease Research Fields Cancer Hedyotis diffusa Willd.	Apoptosis Endogenous Metabolite
4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo .

HY-N11097

FK-3000	Structural Classification Alkaloids Piperidine Alkaloids Source classification Plants Stephania delavayi Diels Menispermaceae	Apoptosis HSV HIV
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against HSV-1 and HIV-1 .

HY-N1381R

Periplocin (Standard)	Structural Classification Source classification Asclepiadaceae Plants Periploca sepium Bunge Steroids	Apoptosis
Periplocin (Standard) is the analytical standard of Periplocin. This product is intended for research and analytical applications. Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

HY-N0247R

Saikosaponin B1 (Standard)	Structural Classification Source classification Umbelliferae Plants Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Smo
Saikosaponin B1 (Standard) is the analytical standard of Saikosaponin B1. This product is intended for research and analytical applications. Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting SMO .

HY-118267

Lentinellic acid	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
Lentinellic acid is an antimicrobial and cytotoxic diterpenoid with biological activity. Lentinellic acid exerts its antimicrobial activity by inhibiting the growth of microorganisms. Lentinellic acid also shows inhibitory effects on tumor cells and has potential anticancer properties. The structure of lentinellic acid was determined by spectroscopic methods and single crystal X-ray analysis .

HY-N3665

Cyclocommunol	Flavonoids Source classification Distemonanthus benthamianus Baill. Plants Compositae Other Flavonoids	Tyrosinase
Cyclocommunol is a prenylflavonoid with antityrosinase and antiplatelet activitie, can be solated from breadfruit. Cyclocommunol exerts anti-tumor activity and inhibits the growth of human hepatoma and gastric cancer cells with IC₅₀ values between 16 and 80 µM. Cyclocommunol shows proapoptotic effect on oral squamous cell carcinoma (OSCC) .

Cat. No.	Product Name	Chemical Structure

HY-B0311AS

Carbidopa-d3 monohydrate
Carbidopa-d₃ (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2].

HY-157029S

KRASG12D-IN-1
KRASG12D-IN-1 (compound 22) is a KRAS ^G12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition .

HY-157031S

KRASG12D-IN-2
KRASG12D-IN-2 (compound 28) is a KRAS ^G12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition .

HY-40136S

cis-4-Hydroxy-L-proline-d3

cis-4-Hydroxy-L-proline-d₃ is the deuterium labeled cis-4-Hydroxy-L-proline. cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4].

HY-50895S1

Gefitinib-d6

Gefitinib-d₆ is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

HY-17406S1

Tolcapone-d4

Tolcapone-d₄ is the deuterium labeled Tolcapone. Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver[1]. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis[2]. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma[3].

HY-50895S2

Gefitinib-d3

Gefitinib-d₃ (ZD1839-d3) is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

HY-B0311S1

Carbidopa-d3-1
Carbidopa-d3-1 is the deuterium labeled Carbidopa (HY-B0311). Carbidopa, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .

HY-B0185AS1

Lidocaine-d6 hydrochloride

Lidocaine-d₆ (hydrochloride) is deuterium labeled Lidocaine (hydrochloride). Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor[2].

HY-50878S

Crizotinib-d5

Crizotinib-d₅ is the deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition .

HY-17507S

Pantoprazole-d6

Pantoprazole-d₆ is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].

HY-17507S1

Pantoprazole-d3

Pantoprazole-d₃ is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].

HY-159176

Antitumor agent-183
Antitumor agent-183 (compound 3f) has antitumor activity with metabolic stability. Antitumor agent-183 inhibits cancer cell growth, with IC₅₀s less than 5 nM for A549, HCT116, and HS578T cells. The albumin-bound nanoparticle formulation of Antitumor agent-183 has prolonged retention in the tumor tissues .

HY-111614S

Melengestrol acetate-d6

Melengestrol acetate-d₆ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-111614S1

Melengestrol acetate-d2

Melengestrol acetate-d₂ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-111614S2

Melengestrol acetate-d3

Melengestrol acetate-d₃ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-W127505S

trans-2-Undecenal-d5
trans-2-Undecenal-d₅ is deuterated labeled 4-Vinylphenol (HY-W005288). 4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo .

HY-50878AS

Crizotinib-d9 hydrochloride

Crizotinib-d₉ hydrochloride is deuterated labeled Crizotinib hydrochloride (HY-50878A). Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition .

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