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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153115

Plasma kallikrein-IN-4	Kallikrein	Cardiovascular Disease Inflammation/Immunology
Plasma kallikrein-IN-4 (Example 153) is a plasma kallikrein inhibitor with an IC₅₀ of 0.016 μM against human plasma kallikrein .

HY-108883

Plasmin, Human plasma Fibrinolysins, Human Plasma; Serum tryptase, Human Plasma; TAL 05-00018, Human Plasma	Others	Inflammation/Immunology
Plasmin, Human plasma is an important protease present in blood that degrades many plasma proteins, including fibrin clots. Plasmin can also act as a potent regulator of the immune process and can directly interact with various cell types, including monocytes, macrophages, and dendritic cells .

HY-150097

Recombinant Human Serum Albumin(rHSA)	Biochemical Assay Reagents	Others
Recombinant Human Serum Albumin (rHSA) is an active compound and possesses an identical conformation to plasma derived HSA. Recombinant Human Serum Albumin (rHSA) has no difference between rHSA and plasma derived HSA. The main physiological function of Recombinant Human Serum Albumin (rHSA) is to regulate plasma pH and maintain plasma osmotic pressure .

HY-150052

Plasma kallikrein-IN-3	Kallikrein	Cardiovascular Disease Metabolic Disease
Plasma kallikrein-IN-3 is a plasma kallikrein inhibitor (IC₅₀: 0.15 μM). Plasma kallikrein-IN-3 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research .

HY-163464

Plasma kallikrein-IN-5	Kallikrein	Cardiovascular Disease
Plasma kallikrein-IN-5 (Compound 20) is a potent covalent inhibitor of plasma potassium kinin peptide (Pka) with IC₅₀ values of 66 nM and 70 pM at 1 minute and 24 hours, respectively. Plasma kallikrein-IN-5 can be used IN the study of hereditary angioedema (HAE) .

HY-143476

Plasma kallikrein-IN-2	Kallikrein	Cardiovascular Disease Metabolic Disease
Plasma kallikrein-IN-2 (Compound 198) is a potent plasma kallikrein (PKal) inhibitor with an IC₅₀ of 0.1 nM. Plasma kallikrein-IN-2 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research .

HY-139888

Plasma kallikrein-IN-1	Kallikrein	Endocrinology
Plasma kallikrein-IN-1 is a PKK inhibitor with an IC₅₀ value of 0.5 nM.

HY-P2728

Antithrombin III, human plasma	Biochemical Assay Reagents	Cardiovascular Disease
Antithrombin III, human plasma is a blood coagulation inhibitory enzyme with high catalytic efficiency, high specificity, mild action conditions, etc., and can be used in the pharmaceutical industry, industrial production, food manufacturing, aquaculture and other industries

HY-P2821

Plasminogen, Human plasma	Others	Inflammation/Immunology
Plasminogen, Human plasma is a secreted protein that upon cleavage by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) is converted to plasmin, a broad range protease capable of cleaving fibrin and other ECM components. Plasminogen also is a proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Plasminogen can be used in studies of wound healing, inflammation and hypoplasminogenemia .

HY-NP018

*Bovine fibrinogen (from plasma)* FGA; FGA protein	NF-κB	Inflammation/Immunology
Bovine fibrinogen (from fibrinogen) is a native fibrinogen from bovine plasma. Bovine fibrinogen (from fibrinogen) can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 .

HY-121243

Halauxifen	Others	Others
Halauxifen is a herbicide with plasma elimination half-life of 1 h .

HY-N6574

Marinobufogenin	Na+/K+ ATPase	Cardiovascular Disease Neurological Disease Metabolic Disease
Marinobufogenin is a strong inhibitor of Na ⁺/K ⁺ ATPase that has been identified in mammalian plasma .

HY-W052051

N-Benzylacetamide N-Acetylbenzylamine	Endogenous Metabolite	Others
N-Benzylacetamide (N-Acetylbenzylamine), as an endogenous metabolite, is the major component of the plasma metabolic profile of Benznidazole (HY-B1548) .

HY-16252

Hexafluorenium dibromide Mylaxen	Cholinesterase (ChE)	Neurological Disease
Hexafluorenium dibromide (Mylaxen) is a potent cholinesterase (ChE) inhibitor with pI₅₀ value of 6.96 and K_i value of 2.4 nM for human plasma cholinesterase (ChE) .

HY-129467

(Rac)-Idroxioleic acid 2-Hydroxyoleic acid; 2-OHOA; LAM561	Apoptosis	Cancer
(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect .

HY-129467A

(Rac)-Idroxioleic acid sodium 2-Hydroxyoleic acid sodium; 2-OHOA sodium; LAM561 sodium	Apoptosis	Cancer
(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid sodium has anti-tumor effect .

HY-133839

Kethoxal	Others	Infection
Kethoxal is a blood-killing agent with no significant toxicity to plasma proteins .

HY-P6053

KK-103	Opioid Receptor	Neurological Disease
KK-103 is a precursor of leucine-enkephalin (Leu-ENK) overcomes high proteolytic instability of Leu-ENK via markedly increased plasma stability in mice that has antinociceptive effect .

HY-12388A

N-Desmethyl clomipramine hydrochloride Desmethylclomipramine hydrochloride; Norclomipramine hydrochloride	Drug Metabolite	Neurological Disease
N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .

HY-132830

Sebetralstat KVD900	Kallikrein	Metabolic Disease
Sebetralstat (KVD900) is a plasma kallikrein inhibitor (WO2016083820). Sebetralstat can be used for the research of metabolic diseases .

HY-101998

CTP inhibitor	Mitochondrial Metabolism Others	Metabolic Disease
CTP inhibitor is a potent and selective CTP inhibitor. CTP inhibitor inhibits the plasma membrane citrate transporter (PMCT) .

HY-143255

Enpp-1-IN-11	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-11 (compound 23) is a potent Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor with an K_i value of 45 nM. Enpp-1-IN-11 exhibits low clearance in human and mouse liver microsomes, good plasma stability in human and mouse plasma. Enpp-1-IN-11 can be used for researching anticancer .

HY-E70362

Butyrylcholinesterase (BCHE), Horse Serum BCHE, BuChE, PCHE, pseudocholinesterase, Plasma cholinesterase, Acylcholine acyl-hydrolase, Choline esterase, butyryl	Others	Others
Butyrylcholinesterase (BCHE), Horse Serum (BCHE, BuChE, PCHE, pseudocholinesterase, plasma cholinesterase, Acylcholine acyl-hydrolase, Choline esterase, butyryl) is a biological material or organic compound that can be used in life science research .

HY-116150

Xymedon	Others	Cardiovascular Disease
Xymedon is a pyrimidine derivative with anti-atherosclerotic effects. Xymedon reducts plasma cholesterol levels and cholesterol esterification in blood vascular cells .

HY-100064

O-Desmethyl gefitinib	EGFR	Cancer
O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC₅₀ of 36 nM in subcellular assays .

HY-N0343A

4-Formylpyrnyl-β-D-glucopyranoside p-Formylphenyl-β-D-glucopyranoside; p-Hydroxybenzaldehyde glucoside	Others	Others
4-Formylpyrnyl-β-D-glucopyranoside (p-Formylphenyl-β-D-glucopyranoside) is a metabolite of Gastrodin (HY-N0115) in rat plasma. 4-Formylpyrnyl-β-D-glucopyranoside can be used to study the effects of multiple doses and food on the pharmacokinetic behavior of oral Gastrodin and its metabolites .

HY-129718

Nafimidone alcohol	Drug Metabolite	Neurological Disease
Nafimidone alcohol is the major metabolic of Nafimidone in plasma and urine. Nafimidone alcohol is promising for research of onset seizures .

HY-P5553

cPcAMP1/26	Bacterial	Infection
cPcAMP1/26 is an antimicrobial peptide. cPcAMP1/26 effectively kills A.hydrophila and S. aureus. cPcAMP1/26 induces depolarization of the bacterial plasma membrane, and increases intracellular ROS levels .

HY-121307

Gliamilide	Others	Metabolic Disease
Gliamilide is an active and well tolerated sulfamylurea derivative and displays a very short plasma half-life. Gliamilide is promising for research of maturity-onset diabetic deseases .

HY-P3278

Caloxin 2A1 1 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 is an extracellular plasma membrane Ca ²⁺-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-121565

SaRI 59-801	Others	Metabolic Disease Endocrinology
SaRI 59-801 is an orally effective hypoglycemic compound. SaRI 59-801 decreases blood glucose in several species and to elevate plasma insulin in rats and mice .

HY-P3278A

Caloxin 2A1 TFA 1 Publications Verification	Proton Pump	Metabolic Disease
Caloxin 2A1 TFA is an extracellular plasma membrane Ca ²⁺-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 TFA does not affect basal Mg ²⁺-ATPase or Na ⁺-K ⁺-ATPase .

HY-113305

Dopamine 3-O-sulfate	Endogenous Metabolite	Metabolic Disease
Dopamine 3-O-sulfate mainly exists in plasma and can be used as a biomarker to characterize aromatic amino acid decarboxylase (AADC) deficiency .

HY-105264

FK224	Neurokinin Receptor	Neurological Disease
FK224 is a tachykinin receptor antagonist. FK224 reduces the tracheal plasma extravasation induced by substance P (SP) and neurokinin A (NKA) .

HY-12388AS

N-Desmethyl clomipramine-d3 hydrochloride Desmethylclomipramine-d₃ (hydrochloride)；Norclomipramine-d₃ hydrochloride	Drug Metabolite	Neurological Disease
N-Desmethyl Clomipramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]

HY-D1091

DiSBAC2(3)	Fluorescent Dye	Neurological Disease
DiSBAC2(3) is an anionic membrane-potential-sensitive dye. DiSBAC2(3) is a plasma membrane potential indicator .

HY-41189

Fmoc-Val-Cit-PAB-PNP	ADC Linker	Cancer
Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Val-Cit-PAB-PNP has superior plasma stability comparable to that of non-cleavable linkers .

HY-164815

S 8849-1 free base Tianeptine metabolite MC5	Drug Metabolite	Neurological Disease
S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants .

HY-P3673

Lamprey LH-RH I	GnRH Receptor	Endocrinology
Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models .

HY-114297

Zymosterol 1 Publications Verification	Endogenous Metabolite	Others
Zymosterol is a Cholesterol (HY-N0322) biosynthesis metabolite. Zymosterol, a precursor of Cholesterol, is found mostly in the plasma membrane. Zymosterol circulates within the cell .

HY-113161

L-Octanoylcarnitine	Endogenous Metabolite	Cancer
L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer .

HY-W354498

L-Octanoylcarnitine hydrochloride	Endogenous Metabolite	Cancer
L-Octanoylcarnitine hydrochloride is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine hydrochloride can be used for the research of breast cancer .

HY-122542

PPACK	PAI-1	Cardiovascular Disease
PPACK is a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK also inhibits the binding of rt-PA to plasma protease inhibitors .

HY-122542A

PPACK dihydrochloride Pebac; D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone; D-Phe-Pro-Arg-CH2Cl	PAI-1	Cardiovascular Disease
PPACK dihydrochloride is a plasminogen activator (rt-PA) inhibitor. PPACK dihydrochloride can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK dihydrochloride also inhibits the binding of rt-PA to plasma protease inhibitors .

HY-157312

TM38837	Cannabinoid Receptor	Metabolic Disease
CB1 antagonist 4 is a inverse agonist of cannabinoid receptor 1 (CB1) with an IC₅₀ of 0.4 nM. CB1 antagonist 4 can reduce body weight, improve plasma inflammatory markers and glucose homeostasis .

HY-W142596

1,2-DImyristoyl-rac-glycero-3-phosphocholine	Liposome	Others
1,2-DImyristoyl-rac-glycero-3-phosphocholine (DMPC), a zwitterionic phospholipid, is chosen as a simple eukaryotic cell membrane, mimicking the neutral charge of the surface membrane of eukaryotic plasma membranes .

HY-123133

PKSI-527	Kallikrein	Inflammation/Immunology
PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system .

HY-13611

Diflomotecan BN 80915	Topoisomerase	Cancer
Diflomotecan (BN 80915) is a potent and orally active inhibitor of topoisomerase I. Diflomotecan (BN 80915) causes enhanced plasma stability and has the superior preclinical anti-tumour activity compared with other established compounds .

HY-101150A

sulfo-DGN462 sodium	DNA Alkylator/Crosslinker ADC Cytotoxin	Cancer
sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML) .

HY-E70074

Monoamine oxidase, plasma	Monoamine Oxidase	Neurological Disease
Monoamine oxidase (EC 1.4.3.4) is an enzyme composed of different polypeptides. Monoamine oxidation catalyzes the oxidative deamination of various biological amines in brain and peripheral tissues by producing hydrogen peroxide. Monoamine oxidase plays an important role in maintaining the regulation of synaptic transmission, emotional behavior and other brain functions .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6574

Marinobufogenin	Classification of Application Fields Neurological Disease Animals Source classification Metabolic Disease Disease Research Fields Steroids	Na+/K+ ATPase
Marinobufogenin is a strong inhibitor of Na ⁺/K ⁺ ATPase that has been identified in mammalian plasma .

HY-114297

Zymosterol 1 Publications Verification	Structural Classification Microorganisms Source classification Endogenous metabolite Steroids	Endogenous Metabolite
Zymosterol is a Cholesterol (HY-N0322) biosynthesis metabolite. Zymosterol, a precursor of Cholesterol, is found mostly in the plasma membrane. Zymosterol circulates within the cell .

HY-113161

L-Octanoylcarnitine	Structural Classification Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer .

HY-W354498

L-Octanoylcarnitine hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
L-Octanoylcarnitine hydrochloride is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine hydrochloride can be used for the research of breast cancer .

HY-P2352

Fetuin, Fetal Bovine Serum 2 Publications Verification	Natural Products Animals Source classification Metabolic Disease Disease Research Fields	Others
Fetuin, Fetal Bovine Serum is a liver-secreted 64 kDa plasma glycoprotein isolated from fetal bovine serum. Fetuin, Fetal Bovine Serum inhibits trypsin activity and promote cellular attachment, growth, and differentiation .

HY-W052051

N-Benzylacetamide N-Acetylbenzylamine	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
N-Benzylacetamide (N-Acetylbenzylamine), as an endogenous metabolite, is the major component of the plasma metabolic profile of Benznidazole (HY-B1548) .

HY-N0343A

4-Formylpyrnyl-β-D-glucopyranoside p-Formylphenyl-β-D-glucopyranoside; p-Hydroxybenzaldehyde glucoside	Structural Classification Gastrodia elata Bl. Orchidaceae Source classification Plants Saccharides Monosaccharides	Others
4-Formylpyrnyl-β-D-glucopyranoside (p-Formylphenyl-β-D-glucopyranoside) is a metabolite of Gastrodin (HY-N0115) in rat plasma. 4-Formylpyrnyl-β-D-glucopyranoside can be used to study the effects of multiple doses and food on the pharmacokinetic behavior of oral Gastrodin and its metabolites .

HY-113305

Dopamine 3-O-sulfate	Structural Classification Natural Products Classification of Application Fields Animals Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Dopamine 3-O-sulfate mainly exists in plasma and can be used as a biomarker to characterize aromatic amino acid decarboxylase (AADC) deficiency .

HY-113161R

L-Octanoylcarnitine (Standard)	Structural Classification Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Endogenous metabolite	Endogenous Metabolite
L-Octanoylcarnitine (Standard) is the analytical standard of L-Octanoylcarnitine. This product is intended for research and analytical applications. L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer .

HY-100313

YM-53601 free base	Structural Classification Alkaloids Carbazole Alkaloids	Farnesyl Transferase HCV
YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

HY-113406

Hexanoylcarnitine	Structural Classification Natural Products Classification of Application Fields Animals Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Others
Hexanoylcarnitine exists in human urine and plasma. Hexanoylcarnitine can be used as a plasma detection indicator in patients with methylmalonic aciduria, propionic acidemia, and medium-chain acyl-CoA dehydrogenase deficiency .

HY-P1255

Kinetensin Kinetensin (human)	Natural Products Monophenols Neurological Disease Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Neurotensin Receptor Endogenous Metabolite
Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.

HY-N8210

Homoeriodictyol	Structural Classification Flavonoids other families Classification of Application Fields Flavonones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Drug Metabolite
Homoeriodictyol is a flavonoid metabolite of Eriocitrin in plasma and urine. Eriocitrin is a strong antioxidant agent .

HY-B1306

4-Aminohippuric acid 3 Publications Verification p-Aminohippuric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Aminohippuric acid is a diagnostic agent used in renal testing and is used in the determination of renal plasma flow.

HY-Y0202

Pyrocatechuic acid Catecholcarboxylic acid; NSC 27435	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Pyrocatechuic acid is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion.

HY-N0864

Macranthoidin B Macranthoiside I	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Macranthoidin B is a major bioactive saponin in rat plasma after oral administration of extraction of saponins from Flos Lonicerae.

HY-B1399

3-Methylsalicylic acid o-Cresotic acid; Hydroxytoluic acid	Cardiovascular Disease Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Methylsalicylic acid is a salicylic acid derivative that acts on human plasma and has significant fibrinolytic activity by activating the fibrinolytic system.

HY-113168

Butyrylcarnitine	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Butyrylcarnitine is a metabolite in plasma, acts as a biomarker to improve the diagnosis and prognosis of heart failure, and is indicative of anomalous lipid and energy metabolism.

HY-N0873A

Iso-Sagittatoside A	Flavonols Flavonoids Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Drug Metabolite
Iso-Sagittatoside A is the metabolite of effective Erxian Decoction (EXD, a Chinese medicine prescription for menopausal syndromes) in rat plasma .

HY-N0368R

Linalool (Standard)	Cardiovascular Disease Structural Classification Classification of Application Fields Terpenoids Source classification Amberboa moschata (L.) DC. Plants Umbelliferae Endogenous metabolite Disease Research Fields	iGluR Apoptosis Endogenous Metabolite
Linalool (Standard) is the analytical standard of Linalool. This product is intended for research and analytical applications. Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity .Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome .

HY-W015611

L-(+)-Arabinose	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides	Endogenous Metabolite
L-(+)-Arabinose selectively inhibits intestinal sucrase activity in a noncompetitive manner and suppresses the plasma glucose increase due to sucrose ingestion.

HY-W004206

2-(4-Methoxyphenyl)acetic acid 4-Methoxyphenylacetic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
2-(4-Methoxyphenyl)acetic acid is a plasma metabolite, with high sensitivity and specificity value as a biomarker for discriminating between NSCLC and healthy controls.

HY-N2327

Oleamide 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Oleamide is an endogenous fatty acid amide which can be synthesized de novo in the mammalian nervous system, and has been detected in human plasma.

HY-N0322

Cholesterol Maximum Cited Publications 34 Publications Verification	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Cancer	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-I1060

L-Alloisoleucine 1 Publications Verification (3R)-LS-Isoleucine; L-Allo-isoleucine	Structural Classification Immune System Disorder Classification of Application Fields Source classification Disease markers Other Diseases Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).

HY-N11429

Glycochenodeoxycholic acid 3-glucuronide	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	Endogenous Metabolite
Glycochenodeoxycholic acid 3-glucuronide is a type of steroid glucuronide and a plasma metabolite that can be used in the research of biomarkers for diabetes and hepatocellular carcinoma (HCC) .

HY-W010589

H-Abu-OH	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.

HY-N4173

8-Oxoepiberberine	Structural Classification other families Stilbenes Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Drug Metabolite
8-Oxoepiberberine is an alkaloid metabolite in the plasma after oral administration of Zuojin formula, a traditional chinese medicine used to treat gastrointestinal disease .

HY-N11932

Piperulin A	Structural Classification Source classification Lignans Piperaceae Phenylpropanoids Plants Piper hongkongense C. de Candolle	Platelet-activating Factor Receptor (PAFR)
Piperulin A is a potent inhibitor of PAFR. Piperulin A inhibits the specific binding of PAFR on isolated rabbit platelet plasma membranes with an IC₅₀ of 7.3 μM .

HY-N11200

3-Hydroxyisovalerylcarnitine	Structural Classification Natural Products Microorganisms Source classification	Endogenous Metabolite
3-Hydroxyisovalerylcarnitine is a carnitine derivative. 3-Hydroxyisovaleryl carnitine in plasma may serve as a novel biomarker of biotin deficiency in humans, with its concentration increasing with biotin deficiency. Biotin deficiency reduces the activity of biotin-dependent 3-methylcrotonyl-CoA carboxylase, hinders the conversion of 3-methylcrotonyl-CoA into 3-methylglutaconyl-CoA, and impairs the leucine catabolism pathway; resulting in plasma 3-Hydroxyisovalerylcarnitine concentrations rise .

HY-P1742

Gluten Exorphin B5	Natural Products Monophenols Classification of Application Fields Source classification Agrostidoideae Phenols Metabolic Disease Plants Disease Research Fields Triticum aestivum L.	Opioid Receptor
Gluten Exorphin B5 is an exogenous opioid peptides derived from wheat gluten, acts on opioid receptor, increases postprandial plasma insulin level in rats .

HY-N0322R

Cholesterol (Standard) Maximum Cited Publications 34 Publications Verification	Structural Classification Classification of Application Fields Anti-aging Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Cancer	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Cholesterol (Standard) is the analytical standard of Cholesterol. This product is intended for research and analytical applications. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-W018161

Hexadecanedioic acid 1 Publications Verification Thapsic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Hexadecanedioic acid is covalently linked to Sepharose 4B, shows better performance in terms of specificity than dye-based resins and could be used for depletion of SA from plasma samples.

HY-W002438

6-Hydroxyindole	Structural Classification Alkaloids Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Indole Alkaloids	Biochemical Assay Reagents Endogenous Metabolite
6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor, and is elevated plasma of the renal failure patients .

HY-120885

(+)-Oxanthromicin	Structural Classification Microorganisms Source classification Phenols Polyphenols	Ras
(+)-Oxanthromicin (Compound 1) mislocalizes the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells, and exhibits thereby antitumor efficacy .

HY-Y0202R

Pyrocatechuic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Endogenous metabolite	Endogenous Metabolite
Pyrocatechuic acid (Standard) is the analytical standard of Pyrocatechuic acid. This product is intended for research and analytical applications. Pyrocatechuic acid is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion.

HY-N0322A

Cholesterol (Water Soluble) Maximum Cited Publications 34 Publications Verification	Structural Classification Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Steroids	Liposome
Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells .

HY-N11506

lsocryptomerin	Structural Classification Flavonoids Source classification Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Fungal Bacterial
lsocryptomerin is a membrane-active antifungal compound that can be isolated from Selaginella tamariscina. lsocryptomerin can depolarize fungal plasma membrane. lsocryptomerin also shows anticancer and antibacterial activities .

HY-N6910

Pseudolaric Acid C2	other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Diterpenoids Plants Disease Research Fields	Others
Pseudolaric Acid C2, a diterpenoid isolated from Pseudolarix kaempferi, is identified as the specific metabolite of Pseudolaric acid B in plasma, urine, bile and feces after both oral and intravenous administration to rats .

HY-23119

Sodium thiocyanate, GR, 99% Thiocyanate sodium	Structural Classification Natural Products Classification of Application Fields Animals Source classification Inflammation/Immunology Disease Research Fields	Interleukin Related Reactive Oxygen Species
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine IL-10 levels. Sodium thiocyanate also significantly reduces of ROS formation .

HY-113168R

Butyrylcarnitine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Butyrylcarnitine (Standard) is the analytical standard of Butyrylcarnitine. This product is intended for research and analytical applications. Butyrylcarnitine is a metabolite in plasma, acts as a biomarker to improve the diagnosis and prognosis of heart failure, and is indicative of anomalous lipid and energy metabolism.

HY-N4202

Dihydrorotenone	Erycibe ferruginea C. Y. Wu Flavonoids Neurological Disease Classification of Application Fields Isoflavanones Source classification Plants Disease Research Fields Convolvulaceae Biological Pesticide Research Agricultural Research	Mitochondrial Metabolism Apoptosis
Dihydrorotenone, a natural pesticide, is a potent mitochondrial inhibitor. Dihydrorotenone probably induces Parkinsonian syndrome. Dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway .

HY-N7875

Celangulin	Structural Classification Natural Products Source classification Celastraceae Celastrus angulatus Maxim. Plants	Others
Celangulin is an insecticidal component isolated from Celastrus angulatus. Celangulin activates the calcium channel on the plasma membrane with increasing the intracellular Ca ²⁺ after influx from the external. Celangulin activates the calcium channel in the ER .

HY-B1306R

4-Aminohippuric acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
4-Aminohippuric acid (Standard) is the analytical standard of 4-Aminohippuric acid. This product is intended for research and analytical applications. 4-Aminohippuric acid is a diagnostic agent used in renal testing and is used in the determination of renal plasma flow.

HY-N2327R

Oleamide (Standard)	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Oleamide (Standard) is the analytical standard of Oleamide. This product is intended for research and analytical applications. Oleamide is an endogenous fatty acid amide which can be synthesized de novo in the mammalian nervous system, and has been detected in human plasma.

HY-W414069

Thiocholesterol	Structural Classification Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite Liposome
Thiocholesterol is a member of the class of cholesteric liquid crystals (CLCs) that can be used to synthesis cationic lipid. Thiocholesterol is a stronger stabilizer of silver nanoparticles (SNPs). Thiocholesterol can be used for plasma membrane research and drug delivery .

HY-W015611R

L-(+)-Arabinose (Standard)	Structural Classification Source classification Endogenous metabolite Saccharides	Endogenous Metabolite
L-(+)-Arabinose (Standard) is the analytical standard of L-(+)-Arabinose. This product is intended for research and analytical applications. L-(+)-Arabinose selectively inhibits intestinal sucrase activity in a noncompetitive manner and suppresses the plasma glucose increase due to sucrose ingestion.

HY-113293B

Estrone sulfate sodium 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Estrogen Receptor/ERR Endogenous Metabolite
Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). Estrone sulfate can be used for the research of breast cancer .

HY-W017100

2-Hydroxy-6-methoxybenzoic acid 6-Methoxysalicylic acid	Monophenols Securidaca inappendiculata Hassk. Ketones, Aldehydes, Acids Source classification Polygalaceae Phenols Plants	Others
2-Hydroxy-6-methoxybenzoic acid can be used for the determination of acetylsalicylic acid and its major metabolite, salicylic acid, in animal plasma. 2-Hydroxy-6-methoxybenzoic acid exhibits significant analgesic effects .

HY-N6073

Soyasapogenol A	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Soyasapogenol A, a triterpene compound, isolated from soybean. Soyasapogenol A directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α, which consequently results in the prevention of liver damage in the Concanavalin A-induced hepatitis model .

Cat. No.	Product Name	Chemical Structure

HY-12388AS

N-Desmethyl clomipramine-d3 hydrochloride
N-Desmethyl Clomipramine-d₃ (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]

HY-N0368S

Linalool-d3
Linalool-d₃ is the deuterium labeled Linalool[1]. Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity[2].Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome[3].

HY-N0322S1

Cholesterol-d6

Cholesterol-d₆ is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S6

Cholesterol-d4

Cholesterol-d₄ is deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-113161S

L-Octanoylcarnitine-d3
L-Octanoylcarnitine-d₃ is the deuterium-labeled L-Octanoylcarnitine (HY-113161). L-Octanoylcarnitine-d₃ is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine-d₃ can be used for the research of breast cancer .

HY-14806S1

Teneligliptin-d4
Teneligliptin-d₄ is deuterium labeled Teneligliptin. Teneligliptin (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor. Teneligliptin competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM[1].

HY-50683S

JNJ-38877605-d1
JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3 .

HY-W654091

(R)-Butyryl carnitine-d5 chloride
(R)-Butyryl carnitine-d₅ chloride is deuterium labeled Butyryl-L-carnitine (chloride). Butyryl-L-carnitine chloride is an acylcarnitine that can be isolated from Plasma/Serum .

HY-N0322S7

Cholesterol-d1

Cholesterol-d is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S8

Cholesterol-18O

Cholesterol- ¹⁸O is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S

Cholesterol-d7

Cholesterol-d₇ is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S4

Cholesterol-13C3

Cholesterol- ¹³C₃ is the ¹³C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S2

Cholesterol-d6-1

Cholesterol-d₆-1 is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S3

Cholesterol-13C5

Cholesterol- ¹³C₅ is the ¹³C-labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-N0322S5

Cholesterol-13C2

Cholesterol- ¹³C₂ is the ¹³C labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

HY-W700539S

N1-Acetyl triethylenetetramine-d4
N1-Acetyl triethylenetetramine-d4 is deuterated N1-Acetyl triethylenetetramine and can be used as an internal standard in plasma extracts .

HY-152007S

Butyrylcarnitine-d3 hydrochloride
Butyrylcarnitine-d₃ (hydrochloride) is deuterium labeled Butyrylcarnitine. Butyrylcarnitine is a metabolite in plasma, acts as a biomarker to improve the diagnosis and prognosis of heart failure, and is indicative of anomalous lipid and energy metabolism .

HY-B1306S

4-Aminohippuric acid-d4
4-Aminohippuric acid-d₄ is the deuterium labeled 4-Aminohippuric acid. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow.

HY-I1060S

L-Alloisoleucine-d10
L-Alloisoleucine-d₁₀ is the deuterium labeled L-Alloisoleucine. L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).

HY-W010589S1

H-Abu-OH-d2
H-Abu-OH-d₂ is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.

HY-W010589S2

H-Abu-OH-d6
H-Abu-OH-d₆ is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.

HY-W018161S

Hexadecanedioic acid-d28
Hexadecanedioic acid-d₂₈ is the deuterium labeled Hexadecanedioic acid. Hexadecanedioic acid is covalently linked to Sepharose 4B, shows better performance in terms of specificity than dye-based resins and could be used for depletion of SA from plasma samples.

HY-W010589S

H-Abu-OH-d3
H-Abu-OH-d₃ is the deuterium labeled H-Abu-OH. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.

HY-113161S1

L-Octanoylcarnitine-d9
L-Octanoylcarnitine-d₉ is deuterium labeled L-Octanoylcarnitine. L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer . .

HY-50667S

Apixaban-13C,d3
Apixaban- ¹³C,d₃ is a deuterium and ¹³C labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[1].

HY-141749AS

Clopidogrel carboxylic acid-d4
Clopidogrel carboxylic acid-d₄ is a deuterated derivative of Clopidogrel carboxylic acid, which is an inactive metabolite of the antiplatelet agent Clopidogrel (HY-15283) in plasma. Clopidogrel carboxylic acid-d₄ can be used to further explore the metabolic characteristics of Clopidogrel .

HY-136450S

Triclabendazole sulfoxide-d3
Triclabendazole sulfoxide-d₃ is the deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].

HY-113293BS

Estrone sulfate-d5 sodium
Estrone sulfate-d₅ (sodium) is the deuterium labeled Estrone sulfate sodium. Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].

HY-113293BS1

Estrone sulfate-d4 sodium
Estrone sulfate-d₄ (sodium) is deuterium labeled Estrone sulfate (sodium). Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS). strone sulfate can be used for the research of breast cancer[1][2].

HY-100064S

O-Desmethyl gefitinib-d8
O-Desmethyl gefitinib-d₈ is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].

HY-70002AS

N-desmethyl Enzalutamide-d6

N-desmethyl Enzalutamide-d₆ is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].

HY-100064S1

O-Desmethyl gefitinib-d6
O-Desmethyl gefitinib-d₆ is the deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].

HY-136450S1

Triclabendazole sulfoxide-13C,d3
Triclabendazole sulfoxide- ¹³C,d₃ is the ¹³C- and deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2].

HY-P5201S

VTSEGAGLQLQK-13C6,15N2
VTSEGAGLQLQK- ¹³C₆, ¹⁵N₂ is the ¹³C and ¹⁵N labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA). VTSEGAGLQLQK can be used to bind anti-drug antibodies (ADA) in plasma and quantitatively analyze the therapeutic effect .

HY-P5201S1

VTSEGAGLQLQK-13C6,15N2 TFA
VTSEGAGLQLQK- ¹³C₆, ¹⁵N₂ (TFA) is the ¹³C- and ¹⁵N-labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA), which can be used to bind anti-drug antibodies in plasma and quantitatively analyze the therapeutic effect .

HY-B0815S

Chlorpyrifos-d10

Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

HY-113046S

5-Methyltetrahydrofolic acid-13C5
5-Methyltetrahydrofolic acid- ¹³C₅ is the ¹³C-labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid[1].

HY-108263S

3-Hydroxy Midostaurin-d5
3-Hydroxy Midostaurin-d₅ is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].

HY-113465S

Leukotriene E4-d5
Leukotriene E4-d₅ is the deuterium labeled Leukotriene E4. Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.

HY-113209S1

8-iso Prostaglandin F2α-d9

8-iso Prostaglandin F2α-d₉ is the deuterium labeled 8-Isoprostaglandin F2α. 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.

HY-B1339AS

Dicyclomine-d4

Dicyclomine-d₄ is the deuterium labeled Dicyclomine[1]. Dicyclomine (Dicycloverine) is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine (Dicycloverine) shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[2]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[3].

HY-113209S2

8-Isoprostaglandin F2α-13C5

8-Isoprostaglandin F2α- ¹³C₅ is ¹³C labeled 8-Isoprostaglandin F2α (HY-113209). 8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.

HY-W754151

N-Desmethyl apalutamide-d4

N-Desmethyl apalutamide-d₄ is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

HY-12765S1

Losartan carboxylic acid-d4 hydrochloride

Losartan carboxylic acid-d₄ (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].

HY-135331S

N-Desmethyl-Apalutamide-15N,d4

N-Desmethyl-Apalutamide-15N,d4 is the ¹⁵N and deuterium labeled isotope of N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .

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