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Synthetic

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1198

Inhibitors & Agonists

14

Screening Libraries

49

Fluorescent Dye

75

Biochemical Assay Reagents

203

Peptides

2

Inhibitory Antibodies

75

Natural
Products

109

Isotope-Labeled Compounds

18

Click Chemistry

34

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-34590
    3-Amino-2,6-piperidinedione

    		Drug Intermediate Cancer
    3-Amino-2,6-piperidinedione is a synthetic intermediate that has been used to design antitumor compounds .
    3-Amino-2,6-piperidinedione
  • HY-P10462
    SAP15

    Synthetic anti-inflammatory peptide 15

    		 HDAC NF-κB Inflammation/Immunology
    SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation. In addition, SAP15 treatment increased the expression of aggrecan and type II collagen and decreased the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials .
    SAP15
  • HY-166863
    L-erythro-Sphingosine(synthetic)

    		Biochemical Assay Reagents Others
    L-erythro-Sphingosine(synthetic) is a biochemical assay reagent.
    L-erythro-Sphingosine(synthetic)
  • HY-P1459
    Sphistin Synthetic Peptide(12-38,Fitc in N-Terminal-Fluorescently Labeled Peptide)

    		Bacterial Infection
    Sphistin Synthetic Peptide (12-38, Fitc in N-Terminal-Fluorescently Labeled Peptide) is a truncated fragments of Sphistin Synthetic Peptide that shows potent antimicrobial activity.
    Sphistin Synthetic Peptide(12-38,Fitc in N-Terminal-Fluorescently Labeled Peptide)
  • HY-43001
    (−)-G-Lactone

    		Drug Intermediate Others
    (−)-G-Lactone is a synthetic intermediate useful for prostaglandins synthesis .
    (−)-G-Lactone
  • HY-60346
    2-Pyrimidinecarboxylic acid

    2-Carboxy-Pyrimidine

    		 Drug Intermediate Infection
    2-Pyrimidinecarboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis .
    2-Pyrimidinecarboxylic acid
  • HY-41240
    (R)-3-Aminoazepan-2-one

    		Drug Intermediate Neurological Disease
    (R)-3-Aminoazepan-2-one (compound 9B) is a synthetic intermediate useful for pharmaceutical synthesis .
    (R)-3-Aminoazepan-2-one
  • HY-164652
    m-BBIG dihydrochloride

    		Biochemical Assay Reagents Others
    m-BBIG dihydrochloride is a member of Bis-iminoguanidine (BIG) family and can be utilized in synthetic chemistry .
    m-BBIG dihydrochloride
  • HY-41004
    3-Isoquinolinecarboxylic acid

    		Drug Intermediate Cancer
    3-Isoquinolinecarboxylic acid (compound 2) is a synthetic intermediate that has been used to design antitumor compounds .
    3-Isoquinolinecarboxylic acid
  • HY-114582
    Lexitropsin

    		DNA Alkylator/Crosslinker Others
    Lexitropsin is a netropsin derivative which is determined the binding and specificity properties in interaction with DNA and synthetic polynucleotides .
    Lexitropsin
  • HY-P10082
    Ac-VETD-AMC

    		Caspase Others
    Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .
    Ac-VETD-AMC
  • HY-161752
    Antibacterial agent 224

    		Bacterial Infection
    Antibacterial agent 224 is a potent and selective synthetic hydrazone inhibitor against the Salmonella PhoP/PhoQ system .
    Antibacterial agent 224
  • HY-B1662
    Hexestrol
    2 Publications Verification

    		 Estrogen Receptor/ERR Endocrinology
    Hexestrol is a nonsteroidal synthetic estrogen, with a Ki of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle .
    Hexestrol
  • HY-129801
    N-Ethyl Hexylone hydrochloride

    		Drug Derivative Others
    N-Ethyl Hexylone hydrochloride is a synthetic Cathinone and analogue of methylone and other beta-keto methylenedioxyamphetamines .
    N-Ethyl Hexylone hydrochloride
  • HY-B0487
    Ethisterone

    Pregneninolone; 17α-Ethynyltestosterone

    		 Estrogen Receptor/ERR Endocrinology
    Ethisterone (Pregneninolone), a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone is reported for androgenic activity, used for the research of the gynecological disorders .
    Ethisterone
  • HY-106365
    Rofleponide

    		Glucocorticoid Receptor Endocrinology
    Rofleponide is a synthetic glucocorticoid that has a high affinity for rat thymic glucocorticoid receptors and has high anti-inflammatory efficacy in experimental animal models .
    Rofleponide
  • HY-B1662R
    Hexestrol (Standard)

    		Estrogen Receptor/ERR Endocrinology
    Hexestrol (Standard) is the analytical standard of Hexestrol. This product is intended for research and analytical applications. Hexestrol is a nonsteroidal synthetic estrogen, with a Ki of 0.06 and 0.06 nM for estrogen receptor alpha (ERα) and ERβ. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle .
    Hexestrol (Standard)
  • HY-P3744
    pp60v-src Autophosphorylation site

    		EGFR Others
    pp60v-src Autophosphorylation site is a synthetic peptide. pp60v-src Autophosphorylation site can be used for various biochemical studies .
    pp60v-src Autophosphorylation site
  • HY-P3489
    β-Corticotropin (swine)

    		Melanocortin Receptor Endocrinology
    β-Corticotropin (swine) is a synthetic form of the peptide hormone corticotropin (ACTH). β-Corticotropin stimulates steroid release .
    β-Corticotropin (swine)
  • HY-137709
    2'2'-cGAMP

    		STING IFNAR Endogenous Metabolite Metabolic Disease
    2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP binds weaker binding to STING than 2'3'-cGAMP (HY-100564) but stronger than other CDNs .
    2'2'-cGAMP
  • HY-122245
    Sortin2

    		Fungal Cancer
    Sortin2 is a synthetic compound and a Yeast vacuolar protein sorting (vps) inhibitor . Sortin2 can affect protein targeting to the vacuole in Saccharomyces cerevisiae .
    Sortin2
  • HY-117444
    ONO-9780307

    		LPL Receptor Cancer
    ONO-9780307 is a specific synthetic LPA1 (lysophosphatidic acid receptor 1) antagonist with an IC50 value of 2.7 nM .
    ONO-9780307
  • HY-B0487R
    Ethisterone (Standard)

    		Estrogen Receptor/ERR Endocrinology
    Ethisterone (Standard) is the analytical standard of Ethisterone. This product is intended for research and analytical applications. Ethisterone (Pregneninolone), a synthetic steroidal estrogen, is an orally active steroidal contraceptive agent. Ethisterone is reported for androgenic activity, used for the research of the gynecological disorders .
    Ethisterone (Standard)
  • HY-W351340
    4-(Benzyloxy)-2-nitrophenol

    		Fluorescent Dye Others
    4-(Benzyloxy)-2-nitrophenol is a synthetic building block that can be used in the synthesis of fluorescent ion indicators .
    4-(Benzyloxy)-2-nitrophenol
  • HY-17578
    Pneumocandin B0

    L-688786

    		 Fungal Antibiotic Infection
    Pneumocandin B0 (L-688786), the precursor of the antifungal agent Caspofungin acetate, is an antifungal agent belonging to the echinocandin family. Pneumocandin B0, derived from the flamentous fungus Glarea lozoyensis, is a synthetic intermediate of Cancidas .
    Pneumocandin B0
  • HY-P10685
    T-22

    [Tyr5,12,Lys7]-Polyphemusin II

    		 HIV CMV Infection
    T-22 (polyphemusin II with [Tyr5,12,Lys7]) is a new synthetic peptide that fights HIV, with an EC50 of 0.008 μg/mL and a CC50 of 54 μg/mL. T22 promotes plant height, photosynthesis, total chlorophyll content, and gas exchange in tomatoes, and it can resist CMV .
    T-22
  • HY-P1701
    Morphiceptin

    		Opioid Receptor Cardiovascular Disease Neurological Disease
    Morphiceptin is a potent and specific agonist for morphine (μ) receptors. Morphiceptin, as a synthetic peptide, is the amide of a fragment of the milk protein β-casein. Morphiceptin has morphinelike activities and is highly specific for morphine (μ) receptors but not for enkephalin (⸹) receptors .
    Morphiceptin
  • HY-N8495
    4'-Hydroxyflavanone

    		Others Metabolic Disease
    4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research .
    4'-Hydroxyflavanone
  • HY-W250152
    Polycytidylic acid potassium

    		Biochemical Assay Reagents Inflammation/Immunology
    Polycytidylic acid potassium is an immunostimulant and synthetic double-stranded RNA. Polycytidylic acid potassium can be used experimentally to model viral infections in vivo. Polycytidylic acid potassium is a common tool in immune system research .
    Polycytidylic acid potassium
  • HY-112205
    RR-11a

    		Legumain Cancer
    RR-11a is a synthetic enzyme inhibitor of Legumain (IC50=31-55 nM). RR-11a can be used for the research of cancer and acute myocardial infarction (AMI) .
    RR-11a
  • HY-167545
    1-Palmitoyl-2-oleoylphosphatidylethanolamine

    POPE

    		 Liposome Biochemical Assay Reagents Others
    1-Palmitoyl-2-oleoylphosphatidylethanolamine (POPE) is a PE-based synthetic phospholipid that can intercalate with other amphiphilic molecules to form stable bilayers at physiological pH. 1-Palmitoyl-2-oleoylphosphatidylethanolamine can be used in drug delivery research .
    1-Palmitoyl-2-oleoylphosphatidylethanolamine
  • HY-109127A
    Berotralstat dihydrochloride
    1 Publications Verification

    BCX7353 dihydrochloride

    		 Kallikrein Others
    Berotralstat dihydrochloride is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat dihydrochloride works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE .
    Berotralstat dihydrochloride
  • HY-D1373
    HBC

    HBC 530

    		 Fluorescent Dye Others
    HBC (HBC 530) is a GFP fluorophore-like synthetic dye, with a structurally rigid electron acceptor and a strong electron donor. HBC is nonfluorescent in solution, and when combined with Pepper (RNA aptamer), HBC forms a tight complex and activates and emits bright fluorescence (Kd of ~3.5 nM). HBC emission peaks vary in different complexes and covers the spectrum from cyan to red. HBC can be used in the live cell imaging of RNA .
    HBC
  • HY-N4115
    Syrosingopine
    5 Publications Verification

    Su 3118

    		 Monocarboxylate Transporter Cardiovascular Disease Cancer
    Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine .
    Syrosingopine
  • HY-P5309
    (Thr(GalNAc)4,7,15,Ser(GalNAc)9,11)-IgA1 Hinge Region Peptide

    		Biochemical Assay Reagents Inflammation/Immunology
    (Thr(GalNAc)4,7,15,Ser(GalNAc)9,11)-IgA1 Hinge Region Peptide is a synthetic glycopeptide and can be used for detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients .
    (Thr(GalNAc)4,7,15,Ser(GalNAc)9,11)-IgA1 Hinge Region Peptide
  • HY-P5309A
    (Thr(GalNAc)4,7,15,Ser(GalNAc)9,11)-IgA1 Hinge Region Peptide TFA

    		Biochemical Assay Reagents Inflammation/Immunology
    (Thr(GalNAc)4,7,15,Ser(GalNAc)9,11)-IgA1 Hinge Region Peptide (TFA) (GN5) is a synthetic glycopeptide and can be used for detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients .
    (Thr(GalNAc)4,7,15,Ser(GalNAc)9,11)-IgA1 Hinge Region Peptide TFA
  • HY-109127R
    Berotralstat (Standard)

    		Ser/Thr Protease Others
    Berotralstat (Standard) is the analytical standard of Berotralstat. This product is intended for research and analytical applications. Berotralstat (BCX7353) is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE .
    Berotralstat (Standard)
  • HY-151661
    N3-L-Val-OH (CHA)

    L-azidovaline (CHA)

    		 ADC Linker Others
    N3-L-Val-OH (CHA) is a click chemistry containing an azide group, a valine derivative. N3-L-Val-OH (CHA) can also be used as a synthetic intermediate for Valaciclovir (Valacyclovir) . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    N3-L-Val-OH (CHA)
  • HY-145860
    PHGDH-IN-2

    		Phosphoglycerate Dehydrogenase (PHGDH) Cancer
    PHGDH-IN-2 is a potent and NAD + competitive PHGDH inhibitor with an IC50 of 5.2 µM. PHGDH-IN-2 inhibits the serine synthetic pathway in MDA-MB-468 cells. PHGDH-IN-2 inhibits the growth of PHGDH-dependent cancer cells .
    PHGDH-IN-2
  • HY-145268
    SLEC-11

    		Cadherin Cancer
    SLEC-11 is a CDH1/E-cadherin modulator that potently inhibits cell death in E-cadherin-deficient cells (EC50=8.2 μM). SLEC-11 can be used to study potential synthetic lethal therapies for gastric cancer .
    SLEC-11
  • HY-B1278B
    (±)-α-Tocopherol acetate

    (±)-Vitamin E acetate

    		 Biochemical Assay Reagents Infection
    (±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases .
    (±)-α-Tocopherol acetate
  • HY-W007977
    4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

    		Drug Intermediate Cancer
    4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline (Compound 11 and 15) is a building block and synthetic intermediate, which can be used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer agents. 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline can also be used to synthesize EGFR inhibitors, including Erlotinib (HY-50896), with antiproliferative activity .
    4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
  • HY-114671
    Taprostene

    CG-4203

    		 Prostaglandin Receptor Cardiovascular Disease
    Taprostene (CG-4203) is a synthetic, chemically stable analogue of Prostacyclin (PGI2). Taprostene exhibits endothelium and myocardial protecting actions after acute myocardial ischemia and reperfusion in cats. Taprostene enhances cytoprotective actions, while minimizing unwanted hemodynamic effects .
    Taprostene
  • HY-P3630
    Stick Insect Hypertrehalosaemic Factor II

    		Biochemical Assay Reagents Others
    Stick Insect Hypertrehalosaemic Factor II is a synthetic peptide. Stick Insect Hypertrehalosaemic Factor II has the same FAB spectra, reversed-phase high-performance liquid chromatographic behavior, and biological behavior as the natural material. Stick Insect Hypertrehalosaemic Factor II can be used for the research of hypertrehalosaemic effect .
    Stick Insect Hypertrehalosaemic Factor II
  • HY-134581A
    Enpatoran hydrochloride
    5+ Cited Publications

    M5049 hydrochloride

    		 Toll-like Receptor (TLR) Inflammation/Immunology
    Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride is inactive against TLR3, TLR4 and TLR9. Enpatoran hydrochloride can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran hydrochloride exhibits excellent pharmacokinetic properties in vivo. Enpatoran hydrochloride can be used for both innate and adaptive autoimmunity blocking research .
    Enpatoran hydrochloride
  • HY-B1278BR
    (±)-α-Tocopherol acetate (Standard)

    		Biochemical Assay Reagents Infection
    (±)-α-Tocopherol acetate (Standard) is the analytical standard of (±)-α-Tocopherol acetate. This product is intended for research and analytical applications. (±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases .
    (±)-α-Tocopherol acetate (Standard)
  • HY-131701
    Lactosyl-C18-sphingosine

    C18 Lactosyl(β) Ceramide; Lactosyl Sphingosine; Lyso-Lactosylceramide (Synthetic)

    		 Endogenous Metabolite Metabolic Disease
    Lactosyl-C18-sphingosine (C18 Lactosyl(β) Ceramide; Lactosyl Sphingosine) is a bioactive sphingolipid that is a form of lactosylceramide but lacks the fatty acyl group. Lysolactosylceramide (1-50 μM) reduces the viability of human neutrophils in a concentration-dependent manner. Unlike lactosylceramide, Lactosyl-C18-sphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes. Lactosyl-C18-sphingosine is a lysoganglioside GM3.
    Lactosyl-C18-sphingosine
  • HY-119506
    KL044
    1 Publications Verification

    		 Cryptochrome Metabolic Disease
    KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity .
    KL044
  • HY-P1626
    Acetyl tetrapeptide-15

    		Opioid Receptor Neurological Disease
    Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway .
    Acetyl tetrapeptide-15
  • HY-B1182
    Chromocarb

    Chromone-2-carboxylic acid

    		 Others Cardiovascular Disease
    Chromocarb is a synthetic vasoprotectant.
    Chromocarb

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