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Mitochondrial Inhibitor

" in MedChemExpress (MCE) Product Catalog:

467

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2

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4

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1

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14

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82

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21

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5

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15886
    Mdivi-1
    160+ Cited Publications

    Mitochondrial division Inhibitor 1

    		 Dynamin Mitophagy Autophagy Apoptosis Cancer
    Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. Mdivi-1 is a mitochondrial division/mitophagy inhibitor.
    Mdivi-1
  • HY-164566
    POSH-IN-2

    		Dynamin Mitochondrial Metabolism Neurological Disease
    POSH-IN-2 (MIDI), a mitochondrial division inhibitor, is a DRP1 inhibitor that potently blocks mitochondrial fragmentation induced by cellular stresses and genetic mitochondrial lesions. POSH-IN-2 covalently interacts with DRP1-C367 to target DRP1 interaction with multiple receptors .
    POSH-IN-2
  • HY-115781
    DN401

    Panvotinib-401; Pan-401

    		 HSP Cancer
    DN401 is a potent TRAP1 inhibitor with an IC50 of 79 nM. DN401 shows a weak inhibition of Hsp90 (IC50 of 698 nM). DN401 inactivates mitochondrial TRAP1 and has potent anticancer activities .
    DN401
  • HY-120035
    DD1

    		Proteasome Ribosomal S6 Kinase (RSK) Apoptosis Cancer
    DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation .
    DD1
  • HY-102007A
    Gamitrinib TPP hexafluorophosphate
    5+ Cited Publications

    		 HSP Cancer
    Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
    Gamitrinib TPP hexafluorophosphate
  • HY-112749
    ME-344

    		Mitochondrial Metabolism Cancer
    ME-344 is a mitochondrial inhibitor. ME-344 has significant biological antitumor activity in HER2-negative breast cancer .
    ME-344
  • HY-108984
    BBMP

    5-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone

    		 Mitochondrial Metabolism Neurological Disease
    BBMP is a permeability transition pore (PTP) inhibitor. BBMP prevents Ca 2+-induced permeability transition and mitochondrial depolarization. BBMP possess potential for the neurodegenerative disorders research .
    BBMP
  • HY-157125
    PI3Kα-IN-14

    		PI3K Apoptosis Cancer
    PI3Kα-IN-14 (compound F8) is a selective PI3Kα inhibitor with an IC50 of 0.14 nM. PI3Kα-IN-14 induces a great decrease in mitochondrial membrane which caused cell cycle arrest at G1 phase and apoptosis in U87-MG cells. PI3Kα-IN-14 shows significant anti-proliferative activities against three tumor-derived cell lines (PC-3: IC50 of 0.28 μM; HCT-116: IC50 of 0.57 μM; and U87-MG: IC50 of 1.37 μM) .
    PI3Kα-IN-14
  • HY-102007
    Gamitrinib TPP

    		HSP Cancer
    Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
    Gamitrinib TPP
  • HY-152202
    Mitochondrial respiration-IN-3

    		Mitochondrial Metabolism Cancer
    Mitochondrial respiration-IN-3 is the fluorine derivative of Dalfopristin (HY-A0241). Mitochondrial respiration-IN-3 has cell membrane-permeable. Mitochondrial respiration-IN-3 can inhibit mitochondrial translation of glioblastoma stem cells. Mitochondrial respiration-IN-3 can be used in research of cancer .
    Mitochondrial respiration-IN-3
  • HY-152203
    Mitochondrial respiration-IN-2

    		Others Cancer
    Mitochondrial respiration-IN-2 is the fluorine derivative of Virginiamycin M1 (HY-N6686). Mitochondrial respiration-IN-2 can inhibit mitochondrial translation of glioblastoma stem cells .
    Mitochondrial respiration-IN-2
  • HY-131453A
    Mitochondrial respiration-IN-1 hydrobromide

    		Mitochondrial Metabolism Metabolic Disease
    Mitochondrial respiration-IN-1 hydrobromide (compound 49) is a potent mitochondrial inhibitor (IC50=8.8 mg/mL) extracted from patent US20110301180A1, compound 49. Mitochondrial respiration-IN-1 hydrobromide significantly reduces mitochondrial respiration in platelets .
    Mitochondrial respiration-IN-1 hydrobromide
  • HY-161267
    Mitochondrial respiration-IN-4

    		Mitochondrial Metabolism Reactive Oxygen Species Cancer
    Mitochondrial respiration-IN-4 (Compound TC11) is a potent mitochondrial respiration inhibitor. Mitochondrial respiration-IN-4 impairs Reactive Oxygen Species (ROS) in and induces apoptosis in MCF7 cells .
    Mitochondrial respiration-IN-4
  • HY-B1756
    Rotenone
    75+ Cited Publications

    		 Mitochondrial Metabolism Autophagy Apoptosis Neurological Disease Cancer
    Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
    Rotenone
  • HY-15453
    Devimistat
    10+ Cited Publications

    CPI-613

    		 Apoptosis Mitochondrial Metabolism Cancer
    Devimistat (CPI-613) is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells .
    Devimistat
  • HY-163316
    SIRT4-IN-1

    		Sirtuin Metabolic Disease Cancer
    SIRT4-IN-1 (compound 69) is selective sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM.SIRT4-IN-1 shows no relevant effects on other sirtuin isoforms .
    SIRT4-IN-1
  • HY-144906
    THP104c

    		Mitochondrial Metabolism Metabolic Disease
    THP104c is a mitochondrial fission inhibitor .
    THP104c
  • HY-150031
    MFI8
    2 Publications Verification

    		 Mitochondrial Metabolism Others
    MFI8 is a small molecule inhibitor of mitochondrial .
    MFI8
  • HY-137067
    IMT1B
    5 Publications Verification

    LDC203974

    		 DNA/RNA Synthesis Cancer
    IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. IMT1B has anti-tumour effects .
    IMT1B
  • HY-114410
    CCI-006

    		Mitochondrial Metabolism Cancer
    CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells .
    CCI-006
  • HY-N1462
    Atractyloside potassium salt
    4 Publications Verification

    		 Chloride Channel Cardiovascular Disease
    Atractyloside potassium salt is a toxic diterpenoid glycoside that can be isolated from the fruits of Xanthium sibiricum. Atractyloside potassium salt is a powerful and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart .
    Atractyloside potassium salt
  • HY-155077
    JNK-IN-12

    		JNK Cancer
    JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor (IC50=66.3 nM), consisting of a mitochondrial-specific cell-penetrating peptide and a specific inhibitor of JNK, SP600125 (HY-12041). JNK-IN-12 doesn't inhibit nuclear JNK signaling, but does inhibit mitochondrial JNK phosphorylation. JNK-IN-12 helps to improve the Parkinson's disease (PD) both in vitro and in vivo .
    JNK-IN-12
  • HY-159518
    ROS inducer 4

    		Reactive Oxygen Species Mitochondrial Metabolism Apoptosis Cancer
    ROS inducer 4 (compound TE3) is a mitochondrial inhibitor. ROS inducer 4 causes a series of mitochondria-related physiological changes in tumors, such as mitochondrial fragmentation, explosive generation and accumulation of ROS, decreased mitochondrial membrane potential, decreased ATP content, and activation of ROS-mediated apoptotic signaling in mitochondria .
    ROS inducer 4
  • HY-103661
    BI-6C9
    1 Publications Verification

    		 Mitochondrial Metabolism Apoptosis Neurological Disease
    BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons .
    BI-6C9
  • HY-14256
    BMS-191095
    1 Publications Verification

    		 Potassium Channel Cardiovascular Disease Neurological Disease
    BMS-191095 is a selective activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. BMS-191095 inhibits human platelet aggregation by opening mitochondrial K(ATP) channels .
    BMS-191095
  • HY-B0486
    Lonidamine
    5+ Cited Publications

    AF-1890; Diclondazolic Acid; DICA

    		 Hexokinase Mitochondrial Metabolism Apoptosis Parasite Inflammation/Immunology Cancer
    Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis .
    Lonidamine
  • HY-N12560
    Fusaramin

    		Mitochondrial Metabolism Infection
    Fusaramin is a mitochondrial inhibitor, has antiplant pathogenic fungal activity .
    Fusaramin
  • HY-N1502
    Carboxyatractyloside tripotassium
    2 Publications Verification

    Gummiferin tripotassium

    		 Others Cancer
    Carboxyatractyloside (Gummiferin) tripotassium is a toxic natural product, acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport from the inner mitochondria to the inner mitochondria. Carboxyatractyloside tripotassium can be used for the study of cellular energy metabolism and mitochondrial biology .
    Carboxyatractyloside tripotassium
  • HY-B1756R
    Rotenone (Standard)

    		Mitochondrial Metabolism Autophagy Apoptosis Neurological Disease Cancer
    Rotenone (Standard) is the analytical standard of Rotenone. This product is intended for research and analytical applications. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
    Rotenone (Standard)
  • HY-138301
    Miclxin

    DS37262926

    		 β-catenin Cancer
    Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex .
    Miclxin
  • HY-163337
    Antifungal agent 92

    		Fungal Infection
    Antifungal agent 92 (Compound 21) is a potent antifungal agent with an EC50 of 4.4 μM against Sclerotinia sclerotiorum. Antifungal agent 92 can induce abnormal mitochondrial morphology, loss of mitochondrial membrane potential, and reactive oxygen species (ROS) accumulation in Sclerotinia sclerotiorum. Antifungal agent 92 is a moderate promiscuous inhibitor of mitochondrial complexes II and III .
    Antifungal agent 92
  • HY-N0832
    L-Histidine
    2 Publications Verification

    		 Mitochondrial Metabolism Endogenous Metabolite Neurological Disease Metabolic Disease Inflammation/Immunology
    L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.
    L-Histidine
  • HY-161119
    Drpitor1a

    		Dynamin Reactive Oxygen Species Cardiovascular Disease Cancer
    Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer [1]
    Drpitor1a
  • HY-B0817
    Pyridaben

    		Parasite Infection
    Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .
    Pyridaben
  • HY-112860
    Asp-AMS

    		Aminoacyl-tRNA Synthetase Mitochondrial Metabolism Metabolic Disease
    Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.
    Asp-AMS
  • HY-100928
    YS 035 hydrochloride

    		Calcium Channel Neurological Disease
    YS 035 hydrochloride is a Ca 2+ antagonist on cellular uptake and mitochondrial efflux of calcium ions. YS 035 hydrochloride inhibits Ca 2+ uptake by muscle cells and inhibits Na +/Ca 2+ exchange (Ki=28 µM). YS 035 hydrochloride is a useful tool for research on the mitochondrial Ca 2+ transport .
    YS 035 hydrochloride
  • HY-136093B
    Lixumistat

    IM156 free base; HL156A free base; HL271 free base

    		 Mitochondrial Metabolism Cancer
    Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat also suppresses B-cell activation to alleviate systemic lupus erythematosus .
    Lixumistat
  • HY-N2522
    Carboxyatractyloside dipotassium
    2 Publications Verification

    Gummiferin dipotassium

    		 Others Others
    Carboxyatractyloside dipotassium is a toxic natural product, acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport .
    Carboxyatractyloside dipotassium
  • HY-111217
    AKOS-22

    		VDAC Mitochondrial Metabolism Neurological Disease Cancer
    AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis. AKOS-22 protects against mitochondrial dysfunction .
    AKOS-22
  • HY-136855
    MitoPBN

    		Endogenous Metabolite Metabolic Disease
    MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP. MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50=~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.
    MitoPBN
  • HY-136804
    CypD-IN-29

    		Others Neurological Disease
    CypD-IN-29 (compound 29) is an inhibitor of the Alzheimer's disease target CypD (KD=88.2 nM). CypD is a mitochondrial-specific cyclophilin that can bind to β-amyloid protein in brain mitochondria and promote the formation of mitochondrial permeability transition pore (mPTP).
    CypD-IN-29
  • HY-155554
    SCAL-255

    		Oxidative Phosphorylation Mitochondrial Metabolism Cancer
    SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-255 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells .
    SCAL-255
  • HY-155555
    SCAL-266

    		Oxidative Phosphorylation Mitochondrial Metabolism Cancer
    SCAL-266 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 0.83 μM. SCAL-266 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-266 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells .
    SCAL-266
  • HY-B0486R
    Lonidamine (Standard)

    		Hexokinase Mitochondrial Metabolism Apoptosis Parasite Inflammation/Immunology Cancer
    Lonidamine (Standard) is the analytical standard of Lonidamine. This product is intended for research and analytical applications. Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis .
    Lonidamine (Standard)
  • HY-114898
    ML404

    		Others Cardiovascular Disease Neurological Disease
    ML404 (Compound 38) is an inhibitor of the mitochondrial permeability transition pore (mtPTP), which can suppress mitochondrial swelling (EC50=4.9 nM) and only disrupts mitochondrial coupling (an adverse effect) at concentrations > 100 μM. ML404 can be utilized in research related to multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), muscular dystrophies (MD), myocardial infarction, and stroke .
    ML404
  • HY-150228
    MitoCur-1

    		Others Cancer
    MitoCur-1, a curcumin analogue, is an inhibitor of mitochondrial antioxidative thioredoxin reductase 2 (TrxR2). MitoCur-1 has electrophilic and mitochondrial-targeting properties. MitoCur-1 induces reactive oxygen species (ROS) generation, exerts specifically antitumor efficacy .
    MitoCur-1
  • HY-122481
    Thaspine acetate

    		Topoisomerase Apoptosis Bcl-2 Family Cytochrome P450 Cancer
    Thaspine acetate, an alkaloid, is a topoisomerase I and II inhibitor. Thaspine acetate induces cancer cell apoptosis. Thaspine acetate induces Bak and Bax activation, mitochondrial cytochrome c release and mitochondrial membrane permeabilization. Thaspine acetate can be isoalted from the cortex of the South American tree Croton lechleri .
    Thaspine acetate
  • HY-156120
    CD38 inhibitor 3

    		CD38 Metabolic Disease
    CD38 inhibitor 3 (compound 1) is a potent CD38 inhibitor (IC50=11 nM). CD38 inhibitor 3 can promote mitochondrial biogenesis, reduce lactate levels, and increase NAD+ content and Nrf2 expression. In a model of mitochondrial myopathy, CD38 inhibitor 3 increases muscle contraction/development and improves exercise tolerance in Pus1 -/- mice .
    CD38 inhibitor 3
  • HY-156109
    PDK-IN-2

    		PDHK Mitochondrial Metabolism Cancer
    PDK-IN-2 (Compound 1F) is a PDK inhibitor (IC50: 68 nM). PDK-IN-2 inhibits the cellular expression of PDK1 and PDK4. PDK-IN-2 enhances mitochondrial bioenergetics, attenuates glycolytic phenotypes, and induces cell apoptosis in the mitochondrial pathway. PDK-IN-2 inhibits tumor growth in 4T1 syngeneic mice model .
    PDK-IN-2
  • HY-W762011
    BDE 47

    		Apoptosis Reactive Oxygen Species JNK Oxidative Phosphorylation Neurological Disease Cancer
    BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish .
    BDE 47

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