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By Targets:	Reactive Oxygen Species (231) 5-HT Receptor (2) Acyltransferase (1) ADC Cytotoxin (1) Adenosine Deaminase (1) Adenylate Cyclase (1) Adrenergic Receptor (1) AIM2 (3) Akt (5) Aldehyde Dehydrogenase (ALDH) (1) Aminopeptidase (1) AMPK (1) Amyloid-β (5) Androgen Receptor (2) Antibiotic (51) AP-1 (3) Apoptosis (117) Arenavirus (1) Aryl Hydrocarbon Receptor (1) ATP Synthase (2) Autophagy (44) Bacterial (102) Bcl-2 Family (5) Bcr-Abl (1) BCRP (1) Biochemical Assay Reagents (13) Btk (1) c-Myc (4) Calcium Channel (9) CaMK (1) Carbonic Anhydrase (2) Caspase (8) Cathepsin (1) CDK (3) Ceramidase (1) CGRP Receptor (1) Cholinesterase (ChE) (14) ClpP (1) Complement System (2) COX (9) CRISPR/Cas9 (1) Cuproptosis (1) Cytochrome P450 (7) Dihydroorotate Dehydrogenase (1) Dipeptidyl Peptidase (1) Disulfidptosis (1) DNA Alkylator/Crosslinker (2) DNA Stain (3) DNA/RNA Synthesis (14) Dopamine Receptor (2) Drug Metabolite (5) DYRK (1) E1/E2/E3 Enzyme (1) EGFR (2) Endogenous Metabolite (70) Enterovirus (2) ERK (5) Estrogen Receptor/ERR (7) Farnesyl Transferase (1) Ferroptosis (25) FGFR (1) FKBP (1) FLAP (1) Fluorescent Dye (18) Free Fatty Acid Receptor (1) Fungal (60) G Protein-coupled Receptor Kinase (GRK) (1) GABA Receptor (3) Glutaminase (1) Glutathione Peroxidase (3) HBV (2) HCV (1) HDAC (3) HIF/HIF Prolyl-Hydroxylase (4) Histamine Receptor (3) Histone Methyltransferase (1) HIV (2) HIV Integrase (1) HMG-CoA Reductase (HMGCR) (6) HSP (3) iGluR (1) IKK (1) Interleukin Related (3) IRE1 (1) Isotope-Labeled Compounds (22) JAK (4) JNK (4) Keap1-Nrf2 (9) Lactate Dehydrogenase (3) Lipoxygenase (2) LPL Receptor (3) MALT1 (1) MDM-2/p53 (1) Melanocortin Receptor (1) Methionine Adenosyltransferase (MAT) (1) mGluR (1) Microtubule/Tubulin (11) Mitochondrial Metabolism (11) Mitophagy (1) Mixed Lineage Kinase (1) MMP (5) Monoamine Oxidase (6) mTOR (2) Myosin (1) Na+/K+ ATPase (1) nAChR (1) NADPH Oxidase (3) Necroptosis (2) Neurokinin Receptor (2) NF-κB (16) NKCC (1) NO Synthase (3) NOD-like Receptor (NLR) (7) Notch (2) Nucleoside Antimetabolite/Analog (2) Oxidative Phosphorylation (6) Oxytocin Receptor (1) P-glycoprotein (4) P2X Receptor (3) p38 MAPK (4) PAI-1 (1) Paraptosis (2) Parasite (35) PARP (3) PDHK (1) Phosphatase (3) Phosphodiesterase (PDE) (1) Phospholipase (3) PI3K (8) Polo-like Kinase (PLK) (1) Potassium Channel (4) PPAR (1) Prolyl Endopeptidase (PREP) (2) PROTACs (1) Protease Activated Receptor (PAR) (1) Proteasome (1) Pyroptosis (3) Raf (2) Ras (3) Renin (1) RIP kinase (2) ROR (2) ROS Kinase (3) RSV (1) SARS-CoV (2) SGLT (1) Sirtuin (1) SOD (1) Sodium Channel (1) STAT (2) STING (3) Tau Protein (2) TNF Receptor (2) Toll-like Receptor (TLR) (3) Topoisomerase (8) Trace Amine-associated Receptor (TAAR) (1) TRP Channel (5) TrxR (1) Tyrosinase (2) VDAC (1) VEGFR (4) Virus Protease (1) Wnt (1) α-synuclein (1) β-catenin (5) γ-secretase (1)
By Research Areas:	Cancer (270) Cardiovascular Disease (36) Endocrinology (16) Infection (191) Inflammation/Immunology (147) Metabolic Disease (79) Neurological Disease (100)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Nucleotides and their Analogs (1) Thickeners (1) CpG ODNs (2) Phospholipids (1)

747

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

266

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Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Reactive Oxygen Species

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122921

5-Galloylquinic acid 1 Publications Verification	Reactive Oxygen Species	Cancer
5-Galloylquinic acid, an main scavenger of the reactive oxygen species (ROS) in green tea .

HY-W040143

2',7'-Dichlorofluorescein	Reactive Oxygen Species	Cancer
2',7'-Dichlorofluorescein acts as a fluorescent probe (Ex=496 nm and Em=525 nm) for reactive oxygen species (ROS) measurement .

HY-145707

BAY-179	Mitochondrial Metabolism	Cancer
BAY-179 is a potent, selective, and species cross-reactive complex I inhibitor (IC₅₀=79 µM) .

HY-153591

ROS-IN-1	Reactive Oxygen Species	Infection Neurological Disease Inflammation/Immunology Cancer
ROS-IN-1 is a mitochondrial ROS inhibitor. ROS-IN-1 can reduce oxidative stress or inhibit reactive oxygen species (ROS) production .

HY-N10088

Yukovanol	Others	Others
Yukovanol is a flavanone, which can be isolated from the roots of some Citrus species .

HY-133591

Senecivernine	Bacterial	Infection
Senecivernine, a pyrrolizidine alkaloid isolated from Senecio species, exhibits a weakly mutagenic activity .

HY-N10083

Selaginellin	Reactive Oxygen Species Sirtuin	Cancer
Selaginellin is an inhibitor of Reactive Oxygen Species and an activator of SIRT1. Selaginellin protects endothelial cells against homocysteine-induced senescence by inhibitng reactive oxygen species and upregulating SIRT1 gene expression .

HY-N7152

6-Dehydrogingerdione	Apoptosis	Cancer
6-Dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5 .

HY-158779

Sulfane sulfur probe 4 SSP4	Fluorescent Dye	Others
Sulfane sulfur probe 4 (SSP4) is a fluorescent probe used to detect sulfane sulfur species (E_x/E_m=494/515 nm). Sulfane sulfur probe 4 exhibits high sensitivity in detecting sulfane sulfur, even in the presence of other substances such as homocysteine, methionine, cysteine, glutathione, N-acetyl-L-cysteine, glycine, tyrosine, tryptophan, arginine, and metal ions (Fe ²⁺, Fe ³⁺, Mg ²⁺, Ca ²⁺, and Zn ²⁺) .

HY-116920

Alyssin	Reactive Oxygen Species Microtubule/Tubulin	Cancer
Alyssin, found in Cruciferous Vegetables, exerts anticancer activity in HepG2 by increasing intracellular reactive oxygen species and tubulin depolymerization .

HY-149723

Ferroptosis-IN-5	Ferroptosis	Cancer
Ferroptosis-IN-5 (compound 9c) is a ferroptosis inhibitor with iron-chelating and *reactive oxygen species* (ROS)** scavenging activities .

HY-162365

JD-02	HSP Apoptosis Autophagy	Cancer
JD-02 is a novel Hsp90 inhibitor. JD-02 can induce autophagy and apoptosis. JD-02 increses the level of reactive oxygen species .

HY-133667

Bromoiodoacetamide	Apoptosis	Cancer
Bromoiodoacetamide is a kind of iodinated haloacetamides (I-HAcAms), with cytotoxicity. Bromoiodoacetamide induces cytotoxicity by via reactive oxygen species (ROS) accumulation and apoptosis in HepG-2 cells .

HY-116920A

(R)-Alyssin	Reactive Oxygen Species Microtubule/Tubulin	Cancer
(R)-Alyssin is a enantiomer of Alyssin (HY-116920). Alyssin, found in Cruciferous Vegetables, exerts anticancer activity in HepG2 by increasing intracellular reactive oxygen species and tubulin depolymerization .

HY-116920B

(S)-Alyssin	Reactive Oxygen Species Microtubule/Tubulin	Cancer
(S)-Alyssin is a enantiomer of Alyssin (HY-116920). Alyssin, found in Cruciferous Vegetables, exerts anticancer activity in HepG2 by increasing intracellular reactive oxygen species and tubulin depolymerization .

HY-157296

AChE-IN-47	Cholinesterase (ChE)	Neurological Disease
AChE-IN-47 (compound g17) is a AChE inhibitor with the IC₅₀ of 0.24 μM. AChE-IN-47 inhibits amyloid β peptides self-aggregation. AChE-IN-47 displays neuroprotective effects and effectively suppresses the intracellular accumulation of reactive oxygen species .

HY-145296

Triflumezopyrim	nAChR	Infection
Triflumezopyrim, a mesoionic insecticide, has high efficiency at a low dosage, and is mainly used to control hopper species. Triflumezopyrim mainly acts on the nicotinic acetylcholine receptor (nAChR) inhibition, which is very highly efficient, rapidly effective, and nearly nontoxic to nontarget arthropods .

HY-B0831

Buprofezin	Oxidative Phosphorylation Reactive Oxygen Species	Others
Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase .

HY-122331

Norbormide	Calcium Channel	Cardiovascular Disease
Norbormide shows vasoconstrictor activity by blocking calcium channel. The activity of Norbormide is species- and tissue-specific, endothelium independent, and is restricted to the peripheral arteries of rat. Norbormide is also a toxicant, and the oral LD₅₀s in mouse, hamster, guinea pig and rabbit are 2250, 140, 620, and 1000 mg/kg .

HY-149602

Glutaminase C-IN-2	Glutaminase Reactive Oxygen Species	Cancer
Glutaminase C-IN-2 (compound 11) is glutaminase C (GAC) allosteric inhibitor with an IC₅₀ of 10.64 nM. Glutaminase C-IN-2 regulates the cellular metabolite, thereby increasing *reactive oxygen species* (ROS)** by blocking glutamine metabolism. Glutaminase C-IN-2 has anticancer effects .

HY-N7271

Solanidine	Others	Cancer
Solanidine is a cholestane alkaloid isolated from several potato species including Solanum demissum, Solanum acaule, and Solanum tuberosum. Solanidine can inhibit proliferation and exhibit obvious antitumor effect .

HY-123875A

Ralaniten triacetate EPI-506	Androgen Receptor	Cancer
Ralaniten triacetate (EPI-506), the pro-agent of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7 .

HY-W011777S

Tricaine-d5 methanesulfonate MS-222-d₅	Isotope-Labeled Compounds	Neurological Disease
Tricaine-d₅ (methanesulfonate) is the deuterium labeled Tricaine-d5 methanesulfonate. Tricaine methanesulfonate (MS-222) is a commonly used agent that can suppress or relieve pain. agent for immobilization of aquatic species. Tricaine methanesulfonate, the most widely used agent that can suppress or relieve pain. in fish, has been shown to induce embryotoxic effects in zebrafish .

HY-163002

viFSP1	Ferroptosis	Cancer
viFSP1 is a species-independent inhibitor of FSP1 that induces ferroptosis in FSP1-dependent cells. viFSP1 targets the highly conserved NAD(P)H binding pocket of FSP1 and directly inhibits FSP1. viFSP1 induces lipid peroxidation and has anticancer activity .

HY-158023

DHODH-IN-26	Dihydroorotate Dehydrogenase Reactive Oxygen Species Ferroptosis	Cancer
DHODH-IN-26 (compound B2) is a mitochondria-targeting DHODH inhibitor. DHODH-IN-26 shows anticancer activity, triggers the formation of reactive oxygen species (ROS), promots mitochondrial lipid peroxidation, and induces ferroptosis .

HY-P5265

Tetrapeptide	DNA/RNA Synthesis	Metabolic Disease
Tetrapeptide, an analogue of α-MSH, induces melanin synthesis. Tetrapeptide diminishes DNA damage by reducing the production of reactive oxidative species and enhancing repair of DNA photoproducts .

HY-B0831R

Buprofezin (Standard)	Oxidative Phosphorylation Reactive Oxygen Species	Others
Buprofezin (Standard) is the analytical standard of Buprofezin. This product is intended for research and analytical applications. Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase .

HY-168042

Antibacterial agent 243	Bacterial Fungal	Infection
Antibacterial agent 243 is an antibacterial agent, with EC₅₀ values of 0.64 mg/L for Valsa mali, 26 mg/L for allicin, and 0.33 mg/L for tebuconazole. Antibacterial agent 243 can induce hyphal shrinkage and collapse, trigger the accumulation of reactive oxygen species inside cells, regulate antioxidant enzyme activity, initiate lipid peroxidation, and ultimately cause irreversible oxidative damage to Valsa mali cells .

HY-163301

Antitumor agent-139	Reactive Oxygen Species	Cancer
Antitumor agent-139 (compound 9b) is a liver - and mitochondria-targeting gold(I) complexe, and produces reactive oxygen species (ROS) and facilitates DNA excretion. Antitumor agent-139 inhibits tumor growth in a patient-derived xenograft model of hepatocellular carcinoma .

HY-111278

Pyocyanin 1 Publications Verification Pyocyanine; Sanazin; Sanasin	Reactive Oxygen Species Bacterial Drug Metabolite	Infection Inflammation/Immunology
Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity .

HY-162135

MAT2A-IN-14	Methionine Adenosyltransferase (MAT) Reactive Oxygen Species	Cancer
MAT2A-IN-14 (compound H3) is a MAT2A inhibitor, and generates reactive oxygen species after sonication to specifically degrade cellular MAT2A via rapid oxidative reactions. Combination of MAT2A-IN-14 and sonication induces 87% MAT2A depletion in human colon cancer cell .

HY-110237

BX430	P2X Receptor Calcium Channel	Cardiovascular Disease
BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC₅₀ of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.

HY-155568

Anti-inflammatory agent 47	Reactive Oxygen Species Apoptosis	Neurological Disease Inflammation/Immunology
Flo8 is a potent anti-inflammatory and antioxidant compound. Flo8 inhibits the release of intracellular reactive oxygen species (ROS) and nitric oxide (NO) and suppresses neuronal apoptotic by inhibiting inflammatory and apoptotic signaling pathways. Flo8 can be used for Parkinson's Disease (PD) research .

HY-100367

ES 936	Others	Cancer
ES 936 is a potent and specific NQO1 inhibitor, effective at concentrations over 1000 times lower than the non-specific inhibitor Dicoumarol (HY-N0645). NQO1 is generally considered a detoxification enzyme, capable of directly reducing quinones to hydroquinones, which in turn prevents the formation of reactive oxygen species arising from redox cycling. ES 936 can be utilized in cancer research .

HY-121134

Decylubiquinone	Reactive Oxygen Species	Neurological Disease Cancer
Decylubiquinone is an analog of ubiquinone (coenzyme Q₁₀). Decylubiquinone blocks *reactive oxygen species* (ROS)** production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition .

HY-109654

Ensulizole	Reactive Oxygen Species	Metabolic Disease
Ensulizole is a sulfonated UV absorber and can intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation .

HY-155348

Ru3	PARP	Cancer
Ru3 is a poly(ADP-ribose) polymerase 1 inhibitor. Ru3 induces apoptosisin MCF-7 cells by multiple modes, inclusive of inducing DNA damage, suppressing DNA damage repair, disturbing cell cycle distribution, decreasing the mitochondrial membrane potential, and increasing the intracellular reactive oxygen species levels .

HY-117053

ZM 253270	Neurokinin Receptor	Neurological Disease
ZM 253270 is a species-selective non-peptide NK-2 receptor (NK-2R) antagonist. ZM 253270 competitively inhibits the binding of [ ³H]NKA to native or cloned NK-2R from hamster bladder (K_i=2 nM), but has a weaker inhibitory effect (48-fold) on the binding of [ ³H]NKA to cloned human NK-2R .

HY-135849

Catalase, Aspergillus niger 1 Publications Verification	Reactive Oxygen Species	Cancer
Catalase, Aspergillus niger is a key enzyme in the metabolism of H₂O₂ and reactive oxygen species (ROS), and its expression and localization is markedly altered in tumors . Free oxygen radical scavenger.

HY-P10350

PapRIV	NF-κB	Neurological Disease Inflammation/Immunology
PapRIV is an agonist of BV-2 microglial cells, capable of activating microglial cells through an NF-κB-dependent pathway. PapRIV induces the expression of pro-inflammatory cytokines such as IL-6 and TNFα and increases the production of reactive oxygen species (ROS). PapRIV can cross the blood-brain barrier .

HY-145307

DATPT	Bacterial	Infection Inflammation/Immunology
DATPT is a ₁₂WLVSKF₁₇ peptide-mimetic molecule. DATPT blocks the SNX9-p47phox interaction in the endosome and suppresses reactive oxygen species and inflammatory cytokine production. DATPT with anti-inflammatory and antibacterial functions has the potential for the research of sepsis .

HY-148236

BAY-390	TRP Channel	Inflammation/Immunology
BAY-390 is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC₅₀s of 16, 82, 63 and 35 nM, respectively. BAY-390 can be used for the research of inflammation .

HY-N3562

Cedrin	Reactive Oxygen Species	Neurological Disease
Cedrin is a natural flavonoid that can be found in Cedrus deodara. Cedrin protects PC12 cells against neurotoxicity induced by Aβ1-42. Cedrin can reduce reactive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content .

HY-155158

Anticancer agent 147	Ferroptosis	Cancer
Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo .

HY-158205

HPO-DAEE 4-Hydroperoxy-2-decenoic acid ethyl ester	Reactive Oxygen Species HDAC SOD	Inflammation/Immunology Cancer
HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) elicits nuclear accumulation of Nrf2 and activated antioxidant response element (ARE). HPO-DAEE induces antioxidant genes upregulation (eg: HO-1) through Nrf2-ARE signaling. HPO-DAEE induces reactive oxygen species generation. HPO-DAEE also inhibits histone deacetylase and upregulate expression of extracellular superoxide dismutase via histone acetylation. HPO-DAEE protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways .

HY-B0166

L-Ascorbic acid 40+ Cited Publications L-Ascorbate; Vitamin C	Reactive Oxygen Species Calcium Channel Apoptosis Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-157158

TrxR-IN-6	TrxR Apoptosis	Cancer
TrxR-IN-6 (compound 1d) is a TrxR inhibitor that induces reactive oxygen species (ROS) accumulation and has anticancer activity. TrxR-IN-6 can further lead to redox system collapse, inducing mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and DNA damage. Finally, it causes oxidative stress and induces apoptosis .

HY-132426S

Thiram-d12	Fungal Reactive Oxygen Species	Infection
Thiram-d₁₂ is the deuterium labeled Thiram. Thiram, a fungicides, is widely used on seeds and as foliar agent on turf, vegetables and fruit.Thiram acts as a vulcanization accelerator in the rubber industry[1]. Thiram induces antioxidant defense and oxidative stress. Thiram can act as a prooxidant resulting in the formation of reactive oxygen species (ROS)[2].

HY-W748509

Pipernonaline	Caspase Apoptosis	Cancer
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-144226

NLRP3/AIM2-IN-3 4 Publications Verification	NOD-like Receptor (NLR) AIM2 Pyroptosis	Inflammation/Immunology
NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC₅₀ of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122921

5-Galloylquinic acid 1 Publications Verification	other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Reactive Oxygen Species
5-Galloylquinic acid, an main scavenger of the reactive oxygen species (ROS) in green tea .

HY-N7271

Solanidine	Alkaloids Piperidine Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Solanum tuberosum Linn. Source classification Solanaceae Plants Disease Research Fields Cancer	Others
Solanidine is a cholestane alkaloid isolated from several potato species including Solanum demissum, Solanum acaule, and Solanum tuberosum. Solanidine can inhibit proliferation and exhibit obvious antitumor effect .

HY-111278

Pyocyanin 1 Publications Verification Pyocyanine; Sanazin; Sanasin	Microorganisms Source classification	Reactive Oxygen Species Bacterial Drug Metabolite
Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity .

HY-B0166

L-Ascorbic acid 40+ Cited Publications L-Ascorbate; Vitamin C	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Source classification Endocrine diseases Metabolic Disease Plants Endogenous metabolite Microorganisms Disease markers Moringaceae Nervous System Disorder Disease Research Fields	Reactive Oxygen Species Calcium Channel Apoptosis Endogenous Metabolite
L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-B0166R

L-Ascorbic acid (Standard)	Structural Classification Natural Products Microorganisms Moringa oleifera Lam. Source classification Disease markers Endocrine diseases Moringaceae Nervous System Disorder Plants Endogenous metabolite	Reactive Oxygen Species Calcium Channel Apoptosis Endogenous Metabolite
L-Ascorbic acid (Standard) is the analytical standard of L-Ascorbic acid. This product is intended for research and analytical applications. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-N10088

Yukovanol	Phyllodium pulchellum (L.) Desv. Structural Classification Flavanonols Flavonoids Leguminosae Source classification Plants	Others
Yukovanol is a flavanone, which can be isolated from the roots of some Citrus species .

HY-N10083

Selaginellin	Structural Classification Source classification Phenols Polyphenols Selaginella sinensis (Desv.) Spring Selaginellaceae Plants	Reactive Oxygen Species Sirtuin
Selaginellin is an inhibitor of Reactive Oxygen Species and an activator of SIRT1. Selaginellin protects endothelial cells against homocysteine-induced senescence by inhibitng reactive oxygen species and upregulating SIRT1 gene expression .

HY-N7152

6-Dehydrogingerdione	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Disease Research Fields Zingiberaceae Cancer	Apoptosis
6-Dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5 .

HY-N3562

Cedrin	Structural Classification Cedrus deodara (Roxburgh) G. Don Flavonoids Neurological Disease Classification of Application Fields Pinaceae Flavonones Source classification Plants Disease Research Fields	Reactive Oxygen Species
Cedrin is a natural flavonoid that can be found in Cedrus deodara. Cedrin protects PC12 cells against neurotoxicity induced by Aβ1-42. Cedrin can reduce reactive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content .

HY-W748509

Pipernonaline	Piper longum Linn. Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants	Caspase Apoptosis
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-N2525

Teucvidin	Other Terpenoids other families Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields	Others
Teucvidin is a diterpenoid from Teucrium species .

HY-N4270

Pseudoprotogracillin	other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields Steroids	Others
Pseudoprotogracillin is a steroidal saponin isolated Dioscoreae species .

HY-Y0095

Isethionic acid 2-Hydroxyethanesulfonic acid	Human Gut Microbiota Metabolites other families Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Isethionic acid (2-Hydroxyethanesulfonic acid) is an organosulfur compound. Isethionic acid is widely distributed in animal species and in a few red algal species. Isethionic acid can be used as an anionic detergent and has anti-settlement activity against Balanus amphitrite .

HY-N7258

Neohesperidose	other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields Saccharides	Others
Neohesperidose is a disaccharide isolated from species of typha .

HY-120735

Lascivol	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Others
Lascivol is a bitter compound isolated from Tricholoma species .

HY-N2969

Bulleyanin	Natural Products Classification of Application Fields Labiatae Source classification Other Diseases Plants Disease Research Fields Dalbergia frutescens (Vell.) Britton	Others
Bulleyanin is a compound isolated from isodon species (Labiatae) .

HY-111646

N6-Etheno 2'-deoxyadenosine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Nucleoside Antimetabolite/Analog Endogenous Metabolite
N6-Etheno 2'-deoxyadenosine is a reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced DNA oxidation product, used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues .

HY-N0206

Ardisiacrispin A Deglucocyclamin; LTS-4; Saxifragifolin B	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Ardisia Myrsinaceae Disease Research Fields Cancer	Antibiotic
Ardisiacrispin A (Deglucocyclamin) is a common triterpenoid saponin from Ardisia species. Ardisiacrispin A has similar biological properties with some triterpenoid saponins in A. crenata which is one of the species of genus Ardisia and exhibits cytotoxic effect on tumor cells, immunomodulatory and antiviral activities .

HY-N1199

Stilbostemin B	Structural Classification Stemonaceae Source classification Phenols Polyphenols Plants Stemona tuberosa Lour.	Others
Stilbostemin B is a stilbenoid compound that can be found in Stemona species .

HY-N0879

Pseudobufarenogin ψ-Bufarenogin	Structural Classification Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Others
Pseudobufarenogin is a natural compound extracted from toad species with unknown details.

HY-N8878

Latisxanthone C	Structural Classification Source classification Phenols Polyphenols Plants Compositae Caesalpinia magnifoliolata Metc.	Others
Latisxanthone C (compound 15) is a pyranoxanthonethat can be found in Garcinia species .

HY-N11072

Tremulacin	Structural Classification Natural Products Source classification Plants Populus tremula Salicaceae	Others
Tremulacin is an important glucoside component of several Populus species barks and leaves .

HY-118024

Littorine	Structural Classification Alkaloids Datura stramonium L. Source classification Plants Solanaceae	Others
Littorine is a alkaloid that can be isolated from Anthocercis fittorea and Datura species .

HY-N1541

prim-O-Glucosylangelicain	Structural Classification Flavonoids Ranunculaceae Source classification Cimicifuga foetida Linn. Plants Other Flavonoids	Others
Prim-O-Glucosylangelicain can be isolated from the rhizoma of Cimicifuga species .

HY-N12058

(Z)-9-Nonadecene	Structural Classification Natural Products Animals Source classification	Others
(Z)-9-Nonadecene is the anal secretion of a species of thrips .

HY-N0950

(-)-Conocarpan	Structural Classification Monophenols Source classification Lignans Krameriaceae Phenols Krameria tomentosa A.St.-Hil. Phenylpropanoids Plants	Others
(-)-Conocarpan is a natural compound that can be isolated from various species of Krarneria .

HY-N1308

Simiarenol Simiaren-3β-ol; β-Simiarenol	Triterpenes Structural Classification Terpenoids Source classification Plants Ericaceae Rhododendron simiarum Hance	Others
Simiarenol is triterpene alcohol isolated from the Hong Kong species of rhododendron simiarum .

HY-N4130

25S-Inokosterone	Structural Classification Natural Products Classification of Application Fields Source classification Amaranthaceae Plants Cyathula capitata Moq. Inflammation/Immunology Disease Research Fields	Others
25S-Inokosterone is a phytoecdysone in the roots of two same species of A. bidentata Blume and A. japonica Nakai, and two different species of C. capitata Moq and C. officinalis Kuan. 25S-Inokosterone has the potential for the LPS-induced acute kidney injury research .

HY-B2123

Lactose	Structural Classification Human Gut Microbiota Metabolites Polysaccharides Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Saccharides	Endogenous Metabolite Bacterial
Lactose, a major sugar in the milk of most species, could regulate human’s intestinal microflora.

HY-N11437

5-O-Primeverosylapigenin	Structural Classification Gentianopsis barbata (Froel.) Ma Flavonoids Flavones Source classification Gentianaceae Plants	Others
5-O-Primeverosylapigenin is a primeverosylapigenin, which can be isolated from Gentianaceae species .

HY-N6678

Zearalanone 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Anticancer Disease Research Fields Endocrinology	Estrogen Receptor/ERR
Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .

HY-N0267

Hypaconitine 2 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Ranunculaceae Source classification Aconitum carmichaeli Debx. Plants Inflammation/Immunology Disease Research Fields	TNF Receptor
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism.

HY-127007

Okilactomycin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	Antibiotic
Okilactomycin is a lactone group antibiotic isolated from the culture filtrate of a strain of actinomycetes (Streptomyces species) .

HY-W013863

Djalonensone Alternariol monomethyl ether	Structural Classification other families Classification of Application Fields Source classification Other Diseases Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields	Antibiotic Bacterial
Djalonensone, isolated from the roots of Anthocleista djalonensis (Loganiaceae), is an important taxonomic marker of the plant species .

HY-N2890

Arillatose B 6'-O-Feruloylsucrose	Aristolochia cretica Lam. Structural Classification Monophenols Source classification Phenols Plants Aristolochiaceae	Others
Arillatose B is a sucrose ester that can be isolated from the roots of the Greek endemic species Aristolochia cretica .

HY-113248

3-Nitro-L-tyrosine	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Phenols Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions.

HY-W010104A

Methionine sulfoxide	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Methionine sulfoxide is an oxidation product of methionine with reactive oxygen species and can be regarded as a biomarker of oxidative stress in vivo.

HY-N0006A

(E/Z)-Demethoxycurcumin p-Hydroxycinnamoyl-feruloylmethane	Classification of Application Fields Source classification Phenols Polyphenols Plants Curcuma longa Disease Research Fields Cancer Zingiberaceae	Others
(E/Z)-Demethoxycurcumin (p-Hydroxycinnamoyl-feruloylmethane) is a curcuminoid isolated from curcuma species, with anticoagulative active .

HY-123894

Pelargonidin 3,5-diglucoside chloride	Structural Classification Anthocyans Flavonoids Source classification Hyacinthus orientalis L. Sp. Pl. Plants Asparagaceae Juss.	Reactive Oxygen Species
Pelargonidin 3,5-diglucoside (chloride) is a natural pigment abundantly present in red fruits and vegetables. Pelargonidin 3,5-diglucoside (chloride) acts as a scavenger for reactive oxygen species and reactive nitrogen species . Pelargonidin 3,5-diglucoside (chloride) demonstrates inhibitory effects on enzymes involved in the production of ROS, RNS, and pro-inflammatory cytokines .

HY-W150928

Tridecyl acetate	Structural Classification Natural Products Animals Source classification	Others
Tridecyl acetate is a species-specific female sex pheromone isolated from Adoxophyes sp. (smaller tea tortrix, STT) .

HY-N0335

Indigo 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Leguminosae Indigofera tinctoria Linn. Plants Disease Research Fields Cancer	Fluorescent Dye
Indigo is a deep and rich color dye for indole stain, isolated from the plant Indigofera tinctoria and related species .

HY-W017140

2-Sec-butyl-3-methoxypyrazine SBMP; 2-Sec-butyl-3(5,6)-methoxypyrazine	Natural Products other families Classification of Application Fields Animals Source classification Other Diseases Plants Disease Research Fields	Others
2-Sec-butyl-3-methoxypyrazine (SBMP) is a methoxypyrazine and can be identified in the ladybug species .

HY-121395

Lepiochlorin	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Fungal
Lepiochlorin is an antibiotic metabolite produced by a fungus (Lepiota species) that is cultivated by ants, which can prevent fungal contamination .

HY-N12914

Tanzawaic acid B (+)-Tanzawaic acid B; GS-1302-1; 10-Deoxytanzawaic acid E	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Reactive Oxygen Species
Tanzawaic acid B ((+)-Tanzawaic acid B; GS-1302-1; 10-Deoxytanzawaic acid E) is a superoxide anion production inhibitor and can be isolated from Penicillium citrinum .

HY-N7155

2,4,7-Trihydroxy-9,10-dihydrophenanthrene	Classification of Application Fields Orchidaceae Source classification Phenols Polyphenols Pholidota chinensis Lindl. Plants Disease Research Fields Inflammation/Immunology	Reactive Oxygen Species
2,4,7-Trihydroxy-9,10-dihydrophenanthrene is a dihydrophenanthrene derivative that can be isolated from the air-dried whole plant of Pholidota chinensis Lindl.. 2,4,7-Trihydroxy-9,10-dihydrophenanthrene shows potent activities of IC₅₀ at 16.2 μM in DPPH radical-scavenging assay .

HY-N0657

Pinoresinol Diglucoside	Structural Classification Eucommia ulmoides Oliver Classification of Application Fields Source classification Lignans Other Diseases Eucommiaceae Phenylpropanoids Plants Disease Research Fields	Others
Pinoresinol Diglucoside is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species.

HY-W042284

Tetradecyl acetate	Natural Products Microorganisms Classification of Application Fields Animals Source classification Metabolic Disease Disease Research Fields	Others
Tetradecyl acetate is a sex pheromone produced by Ctenopseustis obliquana females. Tetradecyl acetate can be used to disrupt the mating of pest species .

HY-125060

Viridicatin	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Quinoline Alkaloids Disease Research Fields	Antibiotic Endogenous Metabolite
Viridicatin is a fungal metabolite from Penicillium species. Viridicatin shows slight in vitro antibiotic activity against Mycobacterium tuberculosis .

HY-N9088

2,3-Dihydro-12,13-dihydroxyeuparin	Monophenols Classification of Application Fields Source classification Phenols Plants Compositae Inflammation/Immunology Disease Research Fields Otholobium mexicanum (L.f.) J.W.Grimes	Others
2,3-Dihydro-12,13-dihydroxyeuparin, isolated from Pappobolus species, is a natural product .

HY-18258

Berberine chloride 40+ Cited Publications Natural Yellow 18 chloride	Alkaloids Structural Classification Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite Parasite
Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

Cat. No.	Product Name	Chemical Structure

HY-132426S

Thiram-d12
Thiram-d₁₂ is the deuterium labeled Thiram. Thiram, a fungicides, is widely used on seeds and as foliar agent on turf, vegetables and fruit.Thiram acts as a vulcanization accelerator in the rubber industry[1]. Thiram induces antioxidant defense and oxidative stress. Thiram can act as a prooxidant resulting in the formation of reactive oxygen species (ROS)[2].

HY-B0166S8

L-Ascorbic acid-13C6-1

L-Ascorbic acid- ¹³C₆-1 (L-Ascorbate-1; Vitamin C- ¹³C₆-1) is a ¹³C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-Y1354S

Dimethylamine-d6 hydrochloride
Dimethylamine-d₆ (hydrochloride) is a deuterium labeled Dimethylamine hydrochloride. Dimethylamine hydrochloride is the immediate precursor of dimethylnitrosamine, a known potent carcinogen in a wide variety of animal species[1].

HY-15660S

Efinaconazole-d4
Efinaconazole-d₄ is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively[1]. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species[1].

HY-W011777S

Tricaine-d5 methanesulfonate
Tricaine-d₅ (methanesulfonate) is the deuterium labeled Tricaine-d5 methanesulfonate. Tricaine methanesulfonate (MS-222) is a commonly used agent that can suppress or relieve pain. agent for immobilization of aquatic species. Tricaine methanesulfonate, the most widely used agent that can suppress or relieve pain. in fish, has been shown to induce embryotoxic effects in zebrafish .

HY-N6678S

(Rac)-Zearalanone-d6

(Rac)-Zearalanone-d₆ is the racemate of Zearalanone. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system[1][2].

HY-121324S

Prometryn-d14
Prometryn-d₁₄ is the deuterium labeled Prometryn[1]. Prometryn could improves the control of all weed species and increased lint yield compared with the systems[2].

HY-18258S

Berberine-d6 chloride
Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties[1].

HY-100561S1

Tempol-d17
Tempol-d₁₇ is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS)[2][3].

HY-W013863S

Djalonensone-d3
Djalonensone-d₃ is a deuterium labeled Djalonensone (HY-W013863). Djalonensone, isolated from the roots of Anthocleista djalonensis (Loganiaceae), is an important taxonomic marker of the plant species .

HY-100561S

Tempol-d17,15N
Tempol-d₁₇, ¹⁵N is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS)[2][3].

HY-113248S

3-Nitro-L-tyrosine-d3
3-Nitro-L-tyrosine-d₃ is the deuterium labeled 3-Nitro-L-tyrosine. 3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions[1][2].

HY-B0937S

Amprolium-d7 bromide hydrobromide
Amprolium-d7 (bromide hydrobromide) is a deuterium-labeled of Amprolium (HY-B0937). Amprolium-d7 (bromide hydrobromide) is a coccidiostat used in poultry, is a thiamine analog, and blocks the thiamine transporter of Eimeria species .

HY-113248S1

3-Nitro-L-tyrosine-13C6
3-Nitro-L-tyrosine- ¹³C₆ is the ¹³C labeled 3-Nitro-L-tyrosine[1]. 3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions[2].

HY-B1978S

Iprodione-d5
Iprodione-d₅ is the deuterium labeled Iprodione[1]. Iprodione, a dicarboximide fungicide, has a highly specific action, with a capacity to cause oxidative damage through production of free oxygen radicals (ROS). Iprodione does not appear to be species selective[2].

HY-W770183

Uric acid-13C3
Uric acid- ¹³C₃ is ¹³C-labeled Uric acid (HY-B2130). Uric acid is the end product of purine metabolism in the human body. Uric acid can scavenge reactive oxygen species (ROS), such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation.

HY-Y1840S

3-Methoxyphenol-d3
3-Methoxyphenol-d₃ is deuterated labeled 2-Sec-butyl-3-methoxypyrazine (HY-W017140). 2-Sec-butyl-3-methoxypyrazine (SBMP) is a methoxypyrazine and can be identified in the ladybug species .

HY-B0849S

Azoxystrobin-d4
Azoxystrobin-d₄ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

HY-B2130S1

Uric acid-15N2
Uric acid- ¹⁵N₂ is the ¹⁵N labeled Uric acid . Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-B0450S

Ciclopirox-d11
Ciclopirox-d₁₁ is the deuterium labeled Ciclopirox. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic[1].

HY-B0450S1

Ciclopirox-d11 sodium
Ciclopirox-d₁₁ (sodium) is deuterium labeled Ciclopirox. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic[1].

HY-B1953S

Thiacloprid-d4
Thiacloprid-d₄ is the deuterium labeled Thiacloprid[1]. Thiacloprid, a chloronicotinyl insecticide, is targeted chiefly to control aphid pest species in orchards and vegetables[1]. Thiacloprid destabilizes DNA. Thiacloprid changes the structure and stability of DNA through binding into the minor groove by hydrophobic or hydrogen interactions[2].

HY-W011117S

Danofloxacin-d3
Danofloxacin-d₃ is deuterium labeled Danofloxacin. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase[1][2].

HY-B0849S1

Azoxystrobin-d3
Azoxystrobin-d₃ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis[1].

HY-W011117S1

Danofloxacin-d3-1
Danofloxacin-d3-1 is deuterium labeled Danofloxacin. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase .

HY-14602S

Tramiprosate-d6
Tramiprosate-d₆ is the deuterium labeled Tramiprosate. Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects[1][2][3].

HY-B2130S

Uric acid-13C,15N3
Uric acid- ¹³C, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Uric acid. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2].

HY-14956S

Nemonoxacin-d3

Nemonoxacin-d₃ is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia[1][2][3].

HY-14956S2

Nemonoxacin-d4

Nemonoxacin-d₄ is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia[1][2][3].

HY-17580S

Fidaxomicin-d7
Fidaxomicin-d₇ (OPT-80-D7) is the deuterium labeled Fidaxomicin. Fidaxomicin (OPT-80), a macrocyclic RNA polymerase inhibitor, has a narrow spectrum of activity. Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora[1][2].

HY-14956S1

Nemonoxacin-d3-1

Nemonoxacin-d₃-1 is the deuterium labeled Nemonoxacin. Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia[1][2][3].

HY-B0831S

Buprofezin-d6

Buprofezin-d₆ is the deuterium labeled Buprofezin. Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase[1][2].

HY-N6779S

Patulin-13C7
Patulin- ¹³C₇ (Terinin- ¹³C₇) is the ¹³C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .

HY-Y0740S

4-Methoxybenzaldehyde-d1

4-Methoxybenzaldehyde-d₁ is the deuterium labeled 4-Methoxybenzaldehyde[1]. 4-Methoxybenzaldehyde is a naturally occurring fragrant phenolic compound. 4-Methoxybenzaldehyde has been found in many plant species including horseradish, anise, star anise. 4-Methoxybenzaldehyde is a possible neurotoxicant and it has shown effects that include mortality, attractancy, and interference with host seeking[2].

HY-Y0740S1

4-Methoxybenzaldehyde-d3

4-Methoxybenzaldehyde-d₃ is the deuterium labeled 4-Methoxybenzaldehyde[1]. 4-Methoxybenzaldehyde is a naturally occurring fragrant phenolic compound. 4-Methoxybenzaldehyde has been found in many plant species including horseradish, anise, star anise. 4-Methoxybenzaldehyde is a possible neurotoxicant and it has shown effects that include mortality, attractancy, and interference with host seeking[2].

HY-134928AS

Pyridinium bisretinoid A2E-d4 TFA
Pyridinium bisretinoid A2E-d₄ TFA is the deuterium-labeled Pyridinium bisretinoid A2E (HY-134928). Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species .

HY-Y0740S2

4-Methoxybenzaldehyde-d2

4-Methoxybenzaldehyde-d2 is the deuterium labeled 4-Methoxybenzaldehyde (HY-W041300). 4-Methoxybenzaldehyde (p-anisaldehyde) is a fragrant phenolic compound. 4-Methoxybenzaldehyde has been found in many plant species including horseradish, anise, star anise. 4-Methoxybenzaldehyde is a possible neurotoxicant and it has shown effects that include mortality, attractancy, and interference with host seeking .

HY-119695AS1

Simvastatin acid-d9 ammonium

Simvastatin acid-d₉ ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-W015879S

2-Heptanol-d5
2-Heptanol-d₅ is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation .

HY-117433S

4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d₄ is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].

HY-119695AS

Simvastatin acid-d6 ammonium

Simvastatin acid-d₆ (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].

HY-N7434S

N-Nitrosodiethylamine-d4

N-Nitrosodiethylamine-d₄ is the deuterium labeled N-Nitrosodiethylamine[1]. N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

HY-N7434S1

N-Nitrosodiethylamine-d10

N-Nitrosodiethylamine-d₁₀ is the deuterium labeled N-Nitrosodiethylamine[1]. N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

HY-N5142S1

α-Terpineol-d6

α-Terpineol-d₆ is deuterated labeled Pulegone (HY-N1500). Pulegone, the major chemical constituent of Nepeta catariaessential oil which is an aromatic herb, is one of avian repellents . The molecular target for the repellent action of Pulegone in avian species is nociceptive TRP ankyrin 1 (TRPA1). Pulegone stimulates both TRPM8 and TRPA1 channel in chicken sensory neurons and suppresses the former but not the latter at high concentrations .

HY-B0166S

L-Ascorbic acid-13C6

L-Ascorbic acid- ¹³C₆ is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

HY-B0166S1

L-Ascorbic acid-13C

L-Ascorbic acid- ¹³C is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

HY-B1118S2

Secnidazole-d4

Secnidazole-d₄ is the deuterium labeled Secnidazole[1]. Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis[1][2][3].

HY-B0847S

Propiconazole-d7

Propiconazole-d₇ is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS)[1].

HY-B0847S1

Propiconazole-d3 nitrate

Propiconazole-d₃ (nitrate) is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).

HY-N0060BS

(E)-Ferulic acid-d3

(E)-Ferulic acid-d₃ is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].

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