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Results for "

Ubiquitin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E1/E2/E3 Enzyme (34) 17β-HSD (1) ADC Cytotoxin (1) ADC Linker (12) Akt (3) Aldose Reductase (1) Androgen Receptor (1) Antibiotic (3) Apoptosis (43) Aryl Hydrocarbon Receptor (1) AUTACs (2) Autophagy (12) Bacterial (2) Bcl-2 Family (3) BCL6 (2) Bcr-Abl (2) Biochemical Assay Reagents (1) Btk (3) c-Fms (1) c-Kit (1) c-Met/HGFR (2) c-Myc (1) Caspase (2) CDK (4) Cryptochrome (1) CXCR (1) Deubiquitinase (43) DNA/RNA Synthesis (4) E3 Ligase Ligand-Linker Conjugates (51) EGFR (4) Endogenous Metabolite (1) Ephrin Receptor (1) Epigenetic Reader Domain (11) ERK (1) Estrogen Receptor/ERR (3) Ferroptosis (2) FGFR (1) FKBP (3) FLT3 (2) Glutathione Peroxidase (2) GSK-3 (1) HDAC (2) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) Histone Demethylase (1) Histone Methyltransferase (4) HIV (1) HSP (3) IKK (2) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (2) JAK (1) Keap1-Nrf2 (1) Ligands for E3 Ligase (40) Ligands for Target Protein for PROTAC (7) MDM-2/p53 (14) Microtubule/Tubulin (1) Mitophagy (1) Mixed Lineage Kinase (2) Molecular Glues (14) MyD88 (1) NAMPT (2) NF-κB (4) p97 (2) Parasite (2) PD-1/PD-L1 (1) PDGFR (1) Phosphodiesterase (PDE) (1) PROTAC Linkers (69) PROTACs (53) Proteasome (8) Proton Pump (1) Raf (1) Ras (2) Reactive Oxygen Species (1) ROS Kinase (1) Sirtuin (1) SNIPERs (8) STAT (5) STING (3) Target Protein Ligand-Linker Conjugates (1) Topoisomerase (3) VEGFR (1) YAP (2)
By Research Areas:	Cancer (338) Cardiovascular Disease (1) Endocrinology (1) Infection (4) Inflammation/Immunology (27) Metabolic Disease (6) Neurological Disease (8)
Click Chemistry:	ADC Synthesis (6) TCO (18) DBCO (2) PROTAC Synthesis (30) Azide (7) Alkynes (27)
Oligonucleotides:	Antisense Oligonucleotides (2)

373

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

222

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: E1/E2/E3 Enzyme

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100738

Ubiquitin Isopeptidase Inhibitor I, G5 5 Publications Verification NSC144303	Apoptosis	Cancer
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC₅₀ values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

HY-138698

FT206	Deubiquitinase	Others
FT206 is an inhibitor of *carboxamides as ubiquitin-specific protrase* extracted from patent WO 2020033707 A1, example 11-1 .

HY-12989

LDN-91946	Deubiquitinase	Neurological Disease Cancer
LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a K_{i app} of 2.8 μM .

HY-143346

CCW16	Others	Cancer
CCW16 is the covalent ligand for the E3 ubiquitin ligase RNF4. CCW16 can be used in the synthesis of protein degraders .

HY-W054146

RAMB4 1 Publications Verification	Proteasome	Cancer
RAMB4 is a ubiquitin-proteasome system (UPS)-stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity .

HY-W595340

*E3 ubiquitin* ligase binder-1**	Ligands for E3 Ligase	Cancer
E3 ubiquitin ligase binder-1 (compound 11) is a potent *E3 ubiquitin* ligase** binder. E3 ubiquitin ligase binder-1 is a ligand for E3 Ligase .

HY-103436

NSC624206	E1/E2/E3 Enzyme	Cancer
NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC₅₀ of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC₅₀=13 μM) but has no effect on ubiquitin adenylation .

HY-144980

E3 ligase Ligand 21	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 21 (compound 2) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway .

HY-144983

E3 ligase Ligand 22	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 22 (compound 139) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway .

HY-18327

HLI98C	E1/E2/E3 Enzyme MDM-2/p53	Cancer
HLI98C is a ubiquitin ligase inhibitor. HLI98C inhibits p53 ubiquitylation. HLI98C inhibits HDM2 auto-ubiquitylation .

HY-144985

E3 ligase Ligand 23	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 23 (compound 17-6) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway .

HY-122881

HOIPIN-1 1 Publications Verification JTP-0819958	IKK	Cancer
HOIPIN-1 (JTP-0819958) is a selective *linear ubiquitin* chain assembly complex (LUBAC) inhibitor with an IC₅₀** of 2.8 μM . HOIPIN-1 suppress LUBAC-mediated NF-kB activation in vitro .

HY-49514

SOS1 Ligand intermediate-1	Ligands for E3 Ligase	Cancer
VHL Ligand intermediate-1 (intermediate 18a) is an intermediate in the synthesis of VHL E3 ubiquitin ligase ligand and can be used to synthesize PROTACs .

HY-49515

SOS1 Ligand intermediate-2	Ligands for E3 Ligase	Cancer
VHL Ligand intermediate-2 (compound 18c) is an intermediate for the synthesis of VHL E3 ubiquitin ligase ligand and can be used to synthesize PROTACs .

HY-156382

SPOP-IN-1	Akt ERK E1/E2/E3 Enzyme	Cancer
SPOP-IN-1 is a selective *SPOP E3 ubiquitin* ligase inhibitor. SPOP-IN-1 leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK** in clear-cell renal cell carcinoma .

HY-143715

Cereblon inhibitor 1	Ligands for E3 Ligase	Cancer
Cereblon inhibitor 1, an isoindoline derivative, is a cereblon E3 ubiquitin ligase modulating agent. Cereblon inhibitor 1 has the potential for cancer research.

HY-W145436

Thalidomide-Piperazine 5-fluoride hydrochloride	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-Piperazine 5-fluoride hydrochloride is a derivative of cereblon (CRBN) inhibitor Thalidomide (HY-14658), which can be used as ligands for E3 ubiquitin ligase (Ligands for E3 Ligase) for PROTACs Synthesis .

HY-10949

SMER3	E1/E2/E3 Enzyme	Cancer
SMER3, a Rapamycin enhancer, is a selective *Skp1-Cullin-F-box (SCF) ^Met30 ubiquitin* ligase** inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCF ^Met30 .

HY-129241

AGX51 5+ Cited Publications	Others	Cancer
AGX51 is a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader. AGX51 inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability. AGX51 inhibits the TNBC cell lines with IC₅₀s of nearly 25 μM. AGX51 can be used for the research of cancer .

HY-44432

Navitoclax-piperazine ABT-263-piperazine	Bcl-2 Family Ligands for Target Protein for PROTAC	Cancer
Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604) with anti-tumor activity .

HY-W062696

BC-1382	E1/E2/E3 Enzyme	Inflammation/Immunology
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction (IC₅₀≈ 5 nM).Anti-inflammatory activity .

HY-124834

Nrf2 activator-10	Keap1-Nrf2 Apoptosis	Cancer
Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC₅₀ is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H₂O₂-induced apoptosis.

HY-134417

NSC2805 1 Publications Verification	Others	Cancer
NSC2805 is a *WWP2 ubiquitin* ligase inhibitor that can significant inhibit WWP2 activity with an IC₅₀** of 0.38 μM. NSC2805 can be used for the research of cancer .

HY-43722

Lenalidomide-Br	Ligands for E3 Ligase	Cancer
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602) .

HY-N7695

Physalin B	Apoptosis Autophagy	Cancer
Physalin B, one of the major active steroidal constituents of Cape gooseberry, induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro .

HY-150505

DC-U4106	Deubiquitinase Apoptosis	Cancer
DC-U4106 is a USP8 targeting inhibitor with the K_dvalue of 4.7 μM and the IC₅₀ value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα. DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer .

HY-144841A

(Rac)-Cemsidomide (Rac)-CFT7455	Others	Cancer
(Rac)-Cemsidomide ((Rac)-CFT7455) is a zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) degrader, acting via the ubiquitin proteasome pathway, with a GI₅₀ of 0.05 nM for NCIH929.1 cells. (Rac)-Cemsidomide is the racemic isomer of Cemsidomide (HY-144841A) which is a IKZF1/IKZF3 degrader with anticancer activity .

HY-108468

KL001	Cryptochrome	Metabolic Disease
KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis .

HY-130815

MAK683-CH2CH2COOH	Histone Methyltransferase Ligands for Target Protein for PROTAC	Cancer
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615) .

HY-130815A

MAK683-CH2CH2COOH hydrochloride	Ligands for Target Protein for PROTAC Histone Methyltransferase	Cancer
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615) .

HY-108640A

HLI373 dihydrochloride	MDM-2/p53 Parasite Apoptosis	Infection Cancer
HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents . Antimalarial activity .

HY-108640

HLI373	MDM-2/p53 Parasite Apoptosis	Infection Cancer
HLI373 is an efficacious Hdm2 inhibitor. HLI373 inhibits the ubiquitin ligase activity of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents . Antimalarial activity .

HY-106443A

Arimoclomol maleate 3 Publications Verification BRX-220	HSP	Neurological Disease Metabolic Disease Inflammation/Immunology
Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP) . Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system .

HY-W877989

BWA-522 intermediate-1	Ligands for E3 Ligase	Cancer
BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 (HY-149433) and serves as a ligand molecule for cereblon E3 ubiquitin ligase. BWA-522 is an orally active small molecule protein-targeting chimera (PROTAC) that has significant degradation effects on AR-FL and AR-V7 .

HY-128756

SIAIS178	PROTACs Bcr-Abl	Cancer
SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC₅₀ of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity .

HY-123967

RNF5 inhibitor inh-02	E1/E2/E3 Enzyme	Inflammation/Immunology
RNF5 inhibitor inh-02 is a potent inhibitor of *E3 ubiquitin* ligase RNF5/RMA1. RNF5 inhibitor inh-02 leads to significant F508del-CFTR rescue (EC₅₀**=2.2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh-02 can be used for cystic fibrosis research .

HY-49444

EN450	NF-κB E1/E2/E3 Enzyme	Cancer
EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the *E2 ubiquitin* ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase** and proteasome-dependent mechanism .

HY-106443

Arimoclomol BRX-220 free base	HSP	Neurological Disease Metabolic Disease Inflammation/Immunology
Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) . Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system .

HY-106443B

Arimoclomol citrate BRX-220 citrate	HSP	Neurological Disease Metabolic Disease Inflammation/Immunology
Arimoclomol citrate (BRX-220 citrate) is a co-inducer of heat shock proteins (HSP) . Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system .

HY-130683

Lenalidomide-propargyl-C2-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312) . Lenalidomide-propargyl-C2-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130682

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312) . Lenalidomide-propargyl-C2-amido-Ph-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-18638

TCID 2 Publications Verification 4,5,6,7-Tetrachloroindan-1,3-dione	Deubiquitinase	Neurological Disease
TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective *neuronal ubiquitin* C-terminal hydrolase (UCH-L3) inhibitor with an IC₅₀** of 0.6 μM . TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons .

HY-153424

PROTAC SMARCA2 degrader-1	Target Protein Ligand-Linker Conjugates	Cancer
PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC₅₀<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a target protein ligand-linker conjugate .

HY-133046

VHL Ligand-Linker Conjugates 17	E3 Ligase Ligand-Linker Conjugates	Cancer
VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader . VHL Ligand-Linker Conjugates 17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-D1726

8RK59	Deubiquitinase	Cancer
8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC₅₀ close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59 .

HY-136242

UT-34	Androgen Receptor	Endocrinology Cancer
UT-34 is a potent, selective and orally active second-generation pan-androgen receptor (AR) antagonist and degrader with IC₅₀s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively. UT-34 binds to ligand-binding domain (LBD) and function-1 (AF-1) domains and requires ubiquitin proteasome pathway to degrade the AR. UT-34 has anti-prostate cancer efficacy .

HY-13453

BAY 11-7082 305+ Cited Publications BAY 11-7821	IKK Deubiquitinase Autophagy Apoptosis NF-κB	Inflammation/Immunology Cancer
BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC₅₀=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .

HY-153357

NRX-0492	Btk	Cancer
NRX-0492 is an orally active and potent degrader of BTK. NRX-0492 catalyzes ubiquitylation and proteasomal degradation of BTK with DC₅₀≤0.2 nM and DC₉₀≤0.5 nM, respectively. NRX-0492 inhibits B-cell receptor (BCR)-mediated signaling, transcriptional programs, and chemokine secretion. Moreover, NRX-0492 also links a noncovalent BTK-binding domain to Cereblon. Cereblon is an adaptor protein of the E3 ubiquitin ligase complex .

HY-117846

MLAF50	DNA/RNA Synthesis	Cancer
MLAF50 is apotent REV1 UBM2-Ubiquitin interaction inhibitor. MLAF50 inhibits chromatin co-localization of REV1 with PCNA following DNA-damage induction .

HY-47879

WAY-304671	Others	Others
WAY-304671 is an active molecule and a potential ubiquitin ligase inhibitor.

Cat. No.	Product Name

HY-L050

Ubiquitination Compound Library

271 compounds

Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc.

MCE offers a unique collection of 271 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

HY-L151

PROTAC Library

272 compounds

PROTACs (Proteolysis-targeting chimeras) is a class of molecules that utilize ubiquitin-proteasome system (UPS) to ubiquitinate and degrade target proteins. The PROTACs molecule consists of two ligands joined by a linker. The one-to-one interaction between PROTACs and target proteins determines the high efficiency of PROTACs, making it a potential molecule for targeted protein degradation (TPD) therapy.

MCE supplies a unique collection of 272 PROTACs that effectively degrade target proteins with more powerful screening capability. MCE PROTAC Library is a useful tool for signal pathway research, protein degradation therapy research, drug discovery and drug repurposing, etc.

HY-L180

Mitophagy Compound Library

604 compounds

Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms.

MCE can provide a library of 604 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

HY-L128

E3 Ligase Ligand Library

55 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation.

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 55 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

Cat. No.	Product Name	Type

HY-N2306

Aclacinomycin A 3 Publications Verification Aclarubicin	Fluorescent Dyes/Probes
Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-D1726

8RK59	Fluorescent Dyes/Probes
8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC₅₀ close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59 .

HY-N2306R

Aclacinomycin A (Standard)

Fluorescent Dyes/Probes

Aclacinomycin A (Standard) is the analytical standard of Aclacinomycin A. This product is intended for research and analytical applications. Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

Cat. No.	Product Name	Target	Research Area

HY-P1259A

PR-39 TFA	Proteasome Bacterial	Inflammation/Immunology
PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 TFA stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .

HY-P3830

Beacon (30-73)	Peptides	Metabolic Disease
Beacon (30-73) is an ubiquitin-like protein, consisting of 44 amino acids .

HY-P4095

NoxaBH3	CXCR	Cancer
NoxaBH3 is a cysteine-based cross-linked peptide with increased cell permeability and higher inhibitory activity against Mcl-1. NoxaBH3 binds to the endogenous CXCR4 ligand to produce ubiquitin-Noxabh3 conjugate. NoxaBH3 is then delivered to cancer cells .

HY-P1259

PR-39	Proteasome Bacterial	Inflammation/Immunology
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .

HY-P10416

Q14 Q14 peptide	Deubiquitinase Mitophagy	Others Neurological Disease
Q14 is a polypeptide derived from the USP30 (ubiquitin specific peptidase 30) transmembrane (TM) domain with the ability to inhibit the deubiquitination activity of USP30 (IC₅₀=57.2 nM). Q14 reduces USP30 activity by inhibiting the interaction between the USP30 transmembrane domain and its catalytic domain. Q14 peptide contains the LC3 interaction region (LIR) motif, which enables it to bind to the LC3 and accelerate the formation of autophagosomes, thereby promoting mitophagy. Q14 can be used in the study of neurodegenerative diseases as well as mitochondrial quality control and cell metabolism .

HY-P10412

A11 ANXA1-derived 11 amino acid–long peptide	Ephrin Receptor	Cancer
A11 (ANXA1-derived 11 amino acid–long peptide) is an ANXA1-EphA2 interaction blocker peptide. A11 decreases ANXA1 bound to EphA2 and increased Cbl (an E3 ubiquitin ligase of EphA2) bound to EphA2. A11 efficiently decreases EphA2 level, and substantially increases EphA2 ubiquitination. A11 increases EphA2 internalization and colocalization of EphA2 and Cbl in the NPC cells. A11 inhibits nasopharyngeal carcinoma (NPC) cell proliferation, migration and invasion. A11 inhibits angiogenesis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7695

Physalin B	other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	Apoptosis Autophagy
Physalin B, one of the major active steroidal constituents of Cape gooseberry, induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro .

HY-N0170

Indole-3-carbinol Maximum Cited Publications 9 Publications Verification Indole-3-methanol	Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-N2306

Aclacinomycin A 3 Publications Verification Aclarubicin	Quinones Structural Classification Microorganisms Anthraquinones	Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic
Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-N10332

Leptosphaerodione	Quinones Monophenols Microorganisms Classification of Application Fields Source classification Phenols Naphthalene Quinones Disease Research Fields Cancer	Proteasome
Leptosphaerodione, isolated from Remotididymella sp. Fungus, is a potent ubiquitin-proteasome system (UPS) inhibitor. Leptosphaerodione exhibits cytotoxicity in HeLa cells with IC₅₀ value of 3.2 μM. Anti-tumor agent .

HY-N2306A

Aclacinomycin A hydrochloride Aclarubicin hydrochloride	Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields Cancer	Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic
Aclacinomycin A (Aclarubicin) hydrochloride is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A hydrochloride is an inhibitor of topoisomerase I and II. Aclacinomycin A hydrochloride inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A hydrochloride might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-N2306R

Aclacinomycin A (Standard)	Quinones Structural Classification Microorganisms Anthraquinones	Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic
Aclacinomycin A (Standard) is the analytical standard of Aclacinomycin A. This product is intended for research and analytical applications. Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

Cat. No.	Product Name	Chemical Structure

HY-A0003S

Lenalidomide-d5

Lenalidomide-d₅ is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].

HY-14658S

Thalidomide-d4
Thalidomide-d₄ is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

HY-A0003S2

Lenalidomide-13C5,15N

Lenalidomide- ¹³C₅, ¹⁵N is ¹⁵N and ¹³C labeled Lenalidomide (HY-A0003). Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-161447

USP1-IN-8
USP1-IN-8 (Compound 16) is an inhibitor for ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, with IC₅₀ ≤50 nM. USP1-IN-8 inhibits proliferation of MDA-MB-436 with IC₅₀ ≤50 nM .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80925

	Ubiquitin Antibody FLJ25987; MGC8385; Ubiquitin B; Ubiquitin; UBCEP1; UBCEP2; RPS27A	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Ubiquitin Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 26 kDa, targeting to Ubiquitin. It can be used for WB,IHC-P,ICC/IF,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80364

	Ubiquitin D Antibody	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Ubiquitin D Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 18 kDa, targeting to Ubiquitin D. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80363

	Ubiquitin Antibody (YA022)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Ubiquitin Antibody (YA022) is a non-conjugated and Rabbit origined monoclonal antibody about 77 kDa, targeting to Ubiquitin. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse.

HY-P80365

	Ubiquitin-like modifier-activating enzyme 1 Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse
	Ubiquitin-like modifier-activating enzyme 1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 118 kDa, targeting to Ubiquitin-like modifier-activating enzyme 1. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse.

HY-P83561

	Ubiquitin Protein Ligase E3A Antibody (YA3306) Ubiquitin-protein ligase E3A; UBE3A; E6AP; EPVE6AP; HPVE6A	WB, ICC/IF, IP	Human, Mouse, Rat
	Ubiquitin Protein Ligase E3A Antibody (YA3306) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3306), targeting Ubiquitin Protein Ligase E3A, with a predicted molecular weight of 101 kDa (observed band size: 101 kDa). Ubiquitin Protein Ligase E3A Antibody (YA3306) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

HY-P82588

	Ubiquitin Conjugating Enzyme E2 D3 Antibody (YA2333) Ubiquitin conjugating enzyme E2D 3; UBC4/5; UBCH5C; E2(17)KB3	WB, IP	Human, Mouse, Rat
	Ubiquitin Conjugating Enzyme E2 D3 Antibody (YA2333) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2333), targeting Ubiquitin Conjugating Enzyme E2 D3, with a predicted molecular weight of 17 kDa (observed band size: 17 kDa). Ubiquitin Conjugating Enzyme E2 D3 Antibody (YA2333) can be used for WB, IP experiment in human, mouse, rat background.

HY-P82989

	Ubiquitin Conjugating Enzyme E2 C Antibody (YA2734) UBCH 10; UbcH10; Ube2c	WB	Human
	Ubiquitin Conjugating Enzyme E2 C Antibody (YA2734) is a biotin-conjugated non-conjugated IgG antibody, targeting Ubiquitin Conjugating Enzyme E2 C, with a predicted molecular weight of 20 kDa (observed band size: 20 kDa). Ubiquitin Conjugating Enzyme E2 C Antibody (YA2734) can be used for WB experiment in human background.

HY-P83554

	Ubiquitin 60S Ribosomal Protein L40 Antibody (YA3299) L40; CEP52; RPL40; HUBCEP52	WB, ICC/IF, IP	Human
	Ubiquitin 60S Ribosomal Protein L40 Antibody (YA3299) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3299), targeting Ubiquitin 60S Ribosomal Protein L40, with a predicted molecular weight of 15 kDa (observed band size: 10 kDa). Ubiquitin 60S Ribosomal Protein L40 Antibody (YA3299) can be used for WB, ICC/IF, IP experiment in human background.

HY-P83558

	Ubiquitin Conjugating Enzyme E2 L3 Antibody (YA3303) E2-F1; L-UBC; UBCH7; UbcM4	WB, ICC/IF, IP	Human, Mouse, Rat
	Ubiquitin Conjugating Enzyme E2 L3 Antibody (YA3303) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3303), targeting Ubiquitin Conjugating Enzyme E2 L3, with a predicted molecular weight of 18 kDa (observed band size: 18 kDa). Ubiquitin Conjugating Enzyme E2 L3 Antibody (YA3303) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

HY-P83563

	Ubiquitin Conjugation Factor E4 B Antibody (YA3308) E4; UFD2; HDNB1; UBOX3; UFD2A	WB, ICC/IF	Human, Rat
	Ubiquitin Conjugation Factor E4 B Antibody (YA3308) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3308), targeting Ubiquitin Conjugation Factor E4 B, with a predicted molecular weight of 146 kDa (observed band size: 146 kDa). Ubiquitin Conjugation Factor E4 B Antibody (YA3308) can be used for WB, ICC/IF experiment in human, rat background.

HY-P82233

	Ubiquitin Conjugating Enzyme E2 N Antibody (YA1978) BLU; HEL-S-71; Ubc13; UbCH ben; UbcH13; UBCHBEN; Ube2n	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Ubiquitin Conjugating Enzyme E2 N Antibody (YA1978) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1978), targeting Ubiquitin Conjugating Enzyme E2 N, with a predicted molecular weight of 17 kDa (observed band size: 17 kDa). Ubiquitin Conjugating Enzyme E2 N Antibody (YA1978) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P83041

	CDC34 Antibody (YA2786) CDC34; UBCH3; UBE2R1; Ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1	WB, IP	Human, Mouse, Rat
	CDC34 Antibody (YA2786) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2786), targeting CDC34, with a predicted molecular weight of 27 kDa (observed band size: 32 kDa). CDC34 Antibody (YA2786) can be used for WB, IP experiment in human, mouse, rat background.

HY-P80926

	USP7 Antibody (YA657) DeUbiquitinating enzyme 7; HAUSP; herpes virus associated; Herpes virus associated Ubiquitin specific protease; Herpesvirus-associated Ubiquitin-specific protease; TEF 1; tef-1; TEF1; Ubiquitin carboxyl terminal hydrolase 7; Ubiquitin carboxyl-terminal hy	WB	Human
	USP7 Antibody (YA657) is a non-conjugated and Mouse origined monoclonal antibody about 128 kDa, targeting to USP7 (3E4). It can be used for WB assays with tag free, in the background of Human.

HY-P83556

	SUMO Conjugating Enzyme UBC9 Antibody (YA3301) UBE2I; UBC9; UBCE9; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; p18	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	SUMO Conjugating Enzyme UBC9 Antibody (YA3301) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3301), targeting SUMO Conjugating Enzyme UBC9, with a predicted molecular weight of 18 kDa (observed band size: 18 kDa). SUMO Conjugating Enzyme UBC9 Antibody (YA3301) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P81591

	USP28 Antibody (YA1336) KIAA1515; Ubiquitin carboxyl terminal hydrolase 28; Ubiquitin thioesterase 28; UBP28	WB, ICC/IF, FC	Human
	USP28 Antibody (YA1336) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1336), targeting USP28, with a predicted molecular weight of 122 kDa (observed band size: 135 kDa). USP28 Antibody (YA1336) can be used for WB, ICC/IF, FC experiment in human background.

HY-P83066

	UCHL3 Antibody (YA2811) UCH-L3; Ubiquitin thiolesterase L3; Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCHL3	WB	Human, Mouse, Rat
	UCHL3 Antibody (YA2811) is a biotin-conjugated non-conjugated IgG antibody, targeting UCHL3, with a predicted molecular weight of 26 kDa (observed band size: 26 kDa). UCHL3 Antibody (YA2811) can be used for WB experiment in human, mouse, rat background.

HY-P82072

	*E1 Ubiquitin* Activating Enzyme Antibody (YA1817)** UBA1; A1S9T; UBE1; Ubiquitin-like modifier-activating enzyme 1; Protein A1S9; Ubiquitin-activating enzyme E1	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	E1 Ubiquitin Activating Enzyme Antibody (YA1817) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1817), targeting E1 Ubiquitin Activating Enzyme, with a predicted molecular weight of 118 kDa (observed band size: 118 kDa). E1 Ubiquitin Activating Enzyme Antibody (YA1817) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P81738

	OTUB1 Antibody (YA1483) OTUB1; OTB1; OTU1; HSPC263; Ubiquitin thioesterase OTUB1; DeUbiquitinating enzyme OTUB1; OTU domain-containing Ubiquitin aldehyde-binding protein 1; Otubain-1; hOTU1; Ubiquitin-specific-processing protease OTUB1	WB, IP	Human, Mouse, Rat
	OTUB1 Antibody (YA1483) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1483), targeting OTUB1, with a predicted molecular weight of 31 kDa (observed band size: 31 kDa). OTUB1 Antibody (YA1483) can be used for WB, IP experiment in human, mouse, rat background.

HY-P80905

	SUMO1 Antibody (YA047) SUMO1; SMT3C; SMT3H3; UBL1; OK/SW-cl.43; Small Ubiquitin-related modifier 1; SUMO-1; GAP-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Smt3C; Ubiquitin-like protein	WB, IHC-P	Human, Mouse, Rat
	SUMO1 Antibody (YA047) is a non-conjugated and Rabbit origined monoclonal antibody, targeting to SUMO1. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P83583

	USP14 Antibody (YA3328) TGT; tRNA guanine transglycosylase 60 kD subunit; Ubiquitin carboxyl terminal hydrolase 14; Ubiquitin specific peptidase 14; USP14	WB, ICC/IF, FC	Human, Mouse, Rat
	USP14 Antibody (YA3328) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3328), targeting USP14, with a predicted molecular weight of 56 kDa (observed band size: 56 kDa). USP14 Antibody (YA3328) can be used for WB, ICC/IF, FC experiment in human, mouse, rat background.

HY-P80559

	ATG7 Antibody hAGP7; Ubiquitin-activating enzyme E1-like protein; APG7L	WB	Human, Mouse, Rat
	ATG7 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 78 kDa, targeting to ATG7. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P81832

	UFM1 Antibody (YA1577) Ubiquitin-fold modifier 1; C13orf20	WB, IHC-P, IP	Human, Mouse
	UFM1 Antibody (YA1577) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1577), targeting UFM1, with a predicted molecular weight of 9 kDa (observed band size: 9 kDa). UFM1 Antibody (YA1577) can be used for WB, IHC-P, IP experiment in human, mouse background.

HY-P81589

	USP22 Antibody (YA1334) Ubiquitin carboxyl terminal hydrolase 22; Usp22; USP3L	WB, ICC/IF, IP, FC	Human
	USP22 Antibody (YA1334) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1334), targeting USP22, with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). USP22 Antibody (YA1334) can be used for WB, ICC/IF, IP, FC experiment in human background.

HY-P82885

	EDD Antibody (YA2630) DD5; EDD; EDD1; hHYD; HYD; Rat100; Ubiquitin protein ligase; UBR5	WB	Human, Mouse
	EDD Antibody (YA2630) is a biotin-conjugated non-conjugated IgG antibody, targeting EDD, with a predicted molecular weight of 309 kDa (observed band size: 309 kDa). EDD Antibody (YA2630) can be used for WB experiment in human, mouse background.

HY-P81834

	ZNF364 Antibody (YA1579) E3 Ubiquitin-protein ligase RNF115; Rabring 7; Zinc finger protein 364	WB	Human, Rat
	ZNF364 Antibody (YA1579) is a biotin-conjugated non-conjugated IgG antibody, targeting ZNF364, with a predicted molecular weight of 34 kDa (observed band size: 34 kDa). ZNF364 Antibody (YA1579) can be used for WB experiment in human, rat background.

HY-P81309

	SUMO2/3 Antibody (YA1048) SUMO2; HSMT3; SMT3 homolog 2; SMT3A; Sentrin 2; Smt3B; SMT3H2; SUMO-2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3A; Ubiquitin-like protein SMT3B	WB	Human
	SUMO2/3 Antibody (YA1048) is a biotin-conjugated non-conjugated IgG2b antibody, targeting SUMO2/3, with a predicted molecular weight of 11 kDa. SUMO2/3 Antibody (YA1048) can be used for WB experiment in human background.

HY-P81309A

	SUMO2/3 Antibody (YA1049) SUMO2; HSMT3; SMT3 homolog 2; SMT3A; Sentrin 2; Smt3B; SMT3H2; SUMO-2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3A; Ubiquitin-like protein SMT3B	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	SUMO2/3 Antibody (YA1049) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1049), targeting SUMO2/3, with a predicted molecular weight of 11 kDa (observed band size: 16 kDa). SUMO2/3 Antibody (YA1049) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P81830

	Pellino 1 Antibody (YA1575) Pellino-related intracellular-signaling molecule; RING-type E3 Ubiquitin transferase pellino homolog 1	WB, IP	Human, Rat
	Pellino 1 Antibody (YA1575) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1575), targeting Pellino 1, with a predicted molecular weight of 46 kDa (observed band size: 46 kDa). Pellino 1 Antibody (YA1575) can be used for WB, IP experiment in human, rat background.

HY-P82533

	TRIM25 Antibody (YA2278) TRIM25; EFP; RNF147; ZNF147; E3 Ubiquitin/ISG15 ligase TRIM25; Estrogen-responsive finger protein; RING finger protein 147; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147	WB, ICC/IF, IP	Human, Rat
	TRIM25 Antibody (YA2278) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2278), targeting TRIM25, with a predicted molecular weight of 71 kDa (observed band size: 71 kDa). TRIM25 Antibody (YA2278) can be used for WB, ICC/IF, IP experiment in human, rat background.

HY-P83705

	MDM2 Antibody (YA3442) ACTFS antibody; Double minute 2 protein antibody; E3 Ubiquitin-protein ligase Mdm2 antibody; Hdm 2 antibody; Hdm2 antibody; HDMX antibody; MDM 2 antibody; MDM2 antibody; MDM2 oncogene E3 Ubiquitin protein ligase antibody; Mdm2 p53 E3 Ubiquitin protein ligase homolog antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody; MDM2_HUMAN antibody; MDM2BP antibody; Mouse Double Minute 2 antibody; MTBP antibody; Murine Double Minute Chromosome 2 antibody; Oncoprotein Mdm2 antibody; p53 Binding Protein Mdm2 antibody; p53-binding protein Mdm2 antibody; Ubiquitin protein ligase E3 Mdm2 antibody; Ubiquitin protein ligase E3 Mdm2 antibody	WB, IHC-P, ICC/IF	Human, Monkey
	MDM2 Antibody (YA3442) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA3442), targeting MDM2, with a predicted molecular weight of 55 kDa (observed band size: 90 kDa). MDM2 Antibody (YA3442) can be used for WB, ICC/IF, IHC-P experiment in human, monkey background.

HY-P83493

	SFT Antibody (YA3238) Ubiquitin conjugating enzyme E2 D1; SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1	WB, IHC-P, IP	Human, Mouse
	SFT Antibody (YA3238) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3238), targeting SFT, with a predicted molecular weight of 17 kDa (observed band size: 17 kDa). SFT Antibody (YA3238) can be used for WB, IHC-P, IP experiment in human, mouse background.

HY-P83135

	RNF20 Antibody (YA2880) BRE1-A; hBRE1; RING finger protein 20; E3 Ubiquitin-protein ligase BRE1A; RNF20	WB, ICC/IF, IP, FC	Human, Mouse
	RNF20 Antibody (YA2880) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2880), targeting RNF20, with a predicted molecular weight of 114 kDa (observed band size: 114 kDa). RNF20 Antibody (YA2880) can be used for WB, ICC/IF, IP, FC experiment in human, mouse background.

HY-P83446

	ZNRF2 Antibody (YA3191) E3 Ubiquitin-protein ligase ZNRF2; ZNRF2; Zinc/RING finger protein 2; RNF202; Protein Ells2	WB, IHC-P	Human, Mouse, Rat
	ZNRF2 Antibody (YA3191) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3191), targeting ZNRF2, with a predicted molecular weight of 24 kDa (observed band size: 24 kDa). ZNRF2 Antibody (YA3191) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P82102

	SAE1 Antibody (YA1847) SAE1; AOS1; SUA1; UBLE1A; SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A	WB, ICC/IF, IP, FC	Human, Rat
	SAE1 Antibody (YA1847) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1847), targeting SAE1, with a predicted molecular weight of 38 kDa (observed band size: 38 kDa). SAE1 Antibody (YA1847) can be used for WB, ICC/IF, IP, FC experiment in human, rat background.

HY-P80919

	TRAF6 Antibody TRAF6; RNF85; TNF receptor-associated factor 6; E3 Ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85	WB	Human, Rat
	TRAF6 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 60 kDa, targeting to TRAF6. It can be used for WB assays with tag free, in the background of Human, Rat.

HY-P82878

	ITCH Antibody (YA2623) ITCH; E3 Ubiquitin-protein ligase Itchy homolog; Itch; Atrophin-1-interacting protein 4; AIP4; NFE2-associated polypeptide 1; NAPP1	WB, IHC-P	Human, Mouse, Rat
	ITCH Antibody (YA2623) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2623), targeting ITCH, with a predicted molecular weight of 103 kDa (observed band size: 103 kDa). ITCH Antibody (YA2623) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P83322

	Rad18 Antibody (YA3067) E3 Ubiquitin-protein ligase RAD18; hHR18; hRAD18; RAD18; RAD18; S. cerevisiae; homolog; RING finger protein 73; RNF73	WB, FC	Human, Mouse, Rat
	Rad18 Antibody (YA3067) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3067), targeting Rad18, with a predicted molecular weight of 56 kDa (observed band size: 70 kDa). Rad18 Antibody (YA3067) can be used for WB, FC experiment in human, mouse, rat background.

HY-P81379

	RBX1 Antibody (YA1124) ROC1; RNF75; RBX1; E3 Ubiquitin-protein ligase RBX1; RING finger protein 75; RING-box protein 1 (Rbx1)	IHC-P	Human
	RBX1 Antibody (YA1124) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1124), targeting RBX1. RBX1 Antibody (YA1124) can be used for IHC-P experiment in human background.

HY-P82584

	UBA2 Antibody (YA2329) UBA2; SAE2; UBLE1B; HRIHFB2115; SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B	WB, ICC/IF, IP	Human, Rat
	UBA2 Antibody (YA2329) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2329), targeting UBA2, with a predicted molecular weight of 71 kDa (observed band size: 90 kDa). UBA2 Antibody (YA2329) can be used for WB, ICC/IF, IP experiment in human, rat background.

HY-P82647

	CBL Antibody (YA2392) CBL; CBL2; RNF55; E3 Ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL	WB, ICC/IF, IP	Human
	CBL Antibody (YA2392) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2392), targeting CBL, with a predicted molecular weight of 100 kDa (observed band size: 120 kDa). CBL Antibody (YA2392) can be used for WB, ICC/IF, IP experiment in human background.

HY-P82146

	MIB1 Antibody (YA1891) Dip1; LVNC7; MIB; mib1; ZZANK2; ZZZ6; DAPK-interacting protein 1; Mind bomb homolog 1; RING-type E3 Ubiquitin transferase MIB1	WB, IHC-P, ICC/IF	Human, Mouse
	MIB1 Antibody (YA1891) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1891), targeting MIB1, with a predicted molecular weight of 110 kDa (observed band size: 110 kDa). MIB1 Antibody (YA1891) can be used for WB, IHC-P, ICC/IF experiment in human, mouse background.

HY-P83471

	RNF14 Antibody (YA3216) RNF14; ARA54; HRIHFB2038; E3 Ubiquitin-protein ligase RNF14; Androgen receptor-associated protein 54; HFB30; RING finger protein 14; Triad2 protein	WB	Human, Mouse, Rat
	RNF14 Antibody (YA3216) is a biotin-conjugated non-conjugated IgG antibody, targeting RNF14, with a predicted molecular weight of 54 kDa (observed band size: 54 kDa). RNF14 Antibody (YA3216) can be used for WB experiment in human, mouse, rat background.

HY-P81294

	Phospho-CBL (Tyr774) Antibody (YA1014) CBL; CBL2; RNF55; E3 Ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL	WB, IP	Human, Rat
	Phospho-CBL (Tyr774) Antibody (YA1014) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1014), targeting Phospho-CBL (Tyr774), with a predicted molecular weight of 100 kDa (observed band size: 120 kDa). Phospho-CBL (Tyr774) Antibody (YA1014) can be used for WB, IP experiment in human, rat background.

HY-P81294A

	Phospho-CBL (Ser669) Antibody (YA1015) CBL; CBL2; RNF55; E3 Ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL	WB	Human
	Phospho-CBL (Ser669) Antibody (YA1015) is a biotin-conjugated non-conjugated IgG antibody, targeting Phospho-CBL (Ser669), with a predicted molecular weight of 100 kDa (observed band size: 120 kDa). Phospho-CBL (Ser669) Antibody (YA1015) can be used for WB experiment in human background.

HY-P81998

	Pirh2 Antibody (YA1743) RCHY1; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; RING finger and CHY zinc finger domain-containing protein 1; Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 Ubiquitin-protein ligase Pirh2; RING finger	WB	Human
	Pirh2 Antibody (YA1743) is a biotin-conjugated non-conjugated IgG antibody, targeting Pirh2, with a predicted molecular weight of 30 kDa (observed band size: 30 kDa). Pirh2 Antibody (YA1743) can be used for WB experiment in human background.

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Cat. No.	Product Name		Classification

HY-69220

7-Octynoic acid		Alkynes PROTAC Synthesis
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins . 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-108374

4-Azidobutylamine		PROTAC Synthesis Azide
4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins . 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-153627

GK13S		Alkynes
G13KS is a deubiquitinase UCHL1 ligand and inhibitor. G13KS inhibits recombinant and cellular UCHL1. G13KS reduces levels of monoubiquitin in human glioblastoma cells . GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-114670

Propargyl-PEG4-amine		Alkynes PROTAC Synthesis
Propargyl-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159608

PROTAC Cbl-b-IN-1		Azide
PROTAC Cbl-b-IN-1 (compound 64) is a PROTAC targeting Cbl-b. PROTAC Cbl-b-IN-1 is composed of PROTAC target protein ligand Cbl-b-IN-21 (HY-159615), PROTAC Linker Cbz-Pip-2C-Pip-C-Pip (HY-159617) and E3 ubiquitin ligase ligand (3S) Lenalidomide-5-Br (HY-W797329), where the E3 ubiquitin ligase ligand + Linker conjugate is (3S) Lenalidomide-5-Pip-C-Pip-2C-Pip (HY-159618) ^{[1] ^.}

HY-113921

m-PEG4-propargyl		Alkynes PROTAC Synthesis
m-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-115414

Bis-propargyl-PEG8		Alkynes PROTAC Synthesis
Bis-propargyl-PEG8 (compound 16e) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG8 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-117045

Propargyl-PEG12-OH		PROTAC Synthesis Alkynes
Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG12-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130147

Propargyl-PEG5-OH		PROTAC Synthesis Alkynes
Propargyl-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130390

Propargyl-PEG4-O-C1-NHS ester		PROTAC Synthesis Alkynes
Propargyl-PEG4-O-C1-NHS ester (compound 8) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-O-C1-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130373

Propargyl-PEG9-amine		PROTAC Synthesis Alkynes
Propargyl-PEG9-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG9-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133230

Propargyl-PEG10-amine		Alkynes PROTAC Synthesis
Propargyl-PEG10-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG10-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130378

Propargyl-PEG7-alcohol		PROTAC Synthesis Alkynes
Propargyl-PEG7-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG7-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130382

Propargyl-PEG6-alcohol		PROTAC Synthesis Alkynes
Propargyl-PEG6-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG6-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133229

Propargyl-PEG4-alcohol		PROTAC Synthesis Alkynes
Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG4-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-126977

Propargyl-PEG9-OH		Alkynes PROTAC Synthesis
Propargyl-PEG9-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG9-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130374

Propargyl-PEG8-OH		PROTAC Synthesis Alkynes
Propargyl-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG8-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130375

Propargyl-PEG8-Boc		PROTAC Synthesis Alkynes
Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG8-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130380

Propargyl-PEG7-Boc		PROTAC Synthesis Alkynes
Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG7-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130384

Propargyl-PEG6-Boc		PROTAC Synthesis Alkynes
Propargyl-PEG6-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG6-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130146

Propargyl-PEG3-phosphonic acid diethyl ester		PROTAC Synthesis Alkynes
Propargyl-PEG3-phosphonic acid diethyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG3-phosphonic acid diethyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130389

Propargyl-PEG4-O-C1-Boc		PROTAC Synthesis Alkynes
Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG4-O-C1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130563

Propargyl-PEG3-CH2COOH		Alkynes PROTAC Synthesis
Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG3-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130584

Propargyl-PEG2-MS		Alkynes PROTAC Synthesis
Propargyl-PEG2-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG2-MS is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133049

Propargyl-PEG3-phosphonic acid		PROTAC Synthesis Alkynes
Propargyl-PEG3-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG3-phosphonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-140015

TCO-PEG3-acid		PROTAC Synthesis TCO
TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-141159

TCO-PEG4-acid		TCO
TCO-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141160

TCO-PEG6-acid		TCO
TCO-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141161

TCO-PEG8-acid		TCO
TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141162

TCO-PEG12-acid		TCO
TCO-PEG12-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141166

TCO-PEG3-NHS ester		TCO
TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141168

TCO-PEG6-NHS ester		TCO
TCO-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141169

TCO-PEG8-NHS ester		TCO
TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141177

TCO-PEG2-amine		TCO
TCO-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141178

TCO-PEG3-amine		TCO
TCO-PEG3-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141179

TCO-PEG4-amine		TCO
TCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141180

TCO-PEG6-amine		TCO
TCO-PEG6-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141181

TCO-PEG8-amine		TCO
TCO-PEG8-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141183

TCO-PEG4-biotin		TCO
TCO-PEG4-biotin is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141187

TCO-PEG3-TCO		TCO
TCO-PEG3-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141188

TCO-PEG4-TCO		TCO
TCO-PEG4-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-141189

TCO-PEG8-TCO		TCO
TCO-PEG8-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .

HY-157510

Thalidomide-O-C3-azide		Azide
Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-157511

Thalidomide-O-C5-azide		Azide
Thalidomide-O-C5-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C5-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C5-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-157515

Thalidomide 4'-ether-PEG2-azide		Azide
Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-126885

DBCO-PEG5-NHS ester		PROTAC Synthesis ADC Synthesis DBCO
DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-126976

Propargyl-PEG5-amine		Alkynes PROTAC Synthesis ADC Synthesis
Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG5-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W051634

Propargyl-PEG2-amine		ADC Synthesis Alkynes PROTAC Synthesis
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG2-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-118808

Propargyl-PEG2-NHBoc		ADC Synthesis Alkynes PROTAC Synthesis
Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130387

Propargyl-PEG4-Tos		PROTAC Synthesis Alkynes ADC Synthesis
Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-148130A

Rugonersen sodium RG6091 sodium; RO7248824 sodium		Antisense Oligonucleotides
Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-148130

Rugonersen RG6091; RO7248824		Antisense Oligonucleotides
Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

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