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Pathways Recommended: Antibody-drug Conjugate/ADC Related
Results for "

Human Antibody

" in MedChemExpress (MCE) Product Catalog:

493

Inhibitors & Agonists

6

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14

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2

MCE Kits

1023

Inhibitory Antibodies

199

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2

Isotope-Labeled Compounds

251

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Area
  • HY-P99278

    MT 201; Anti-Human EPCAM Recombinant Antibody

    Inhibitory Antibodies Cancer
    Adecatumumab (Anti-Human EPCAM Recombinant Antibody; MT201) is a full human monoclonal antibody of the IgG1 isotype, targeting human EpCAM. Adecatumumab is expressed in almost all adenocarcinomas, and its activity is not dependent of K-Ras status .
  • HY-P9916

    Anti-Human IL6Rα, Human Antibody

    Interleukin Related Inflammation/Immunology Cancer
    Sarilumab (Anti-Human IL6Rα, Human Antibody) is a human immunoglobulin G1 monoclonal antibody. Sarilumab, a interleukin-6 (IL-6) receptor antagonist, binds to the IL-6 receptor with high affinity and inhibits cis and trans signaling by IL-6, resulting in reduced inflammation. Sarilumab can be used for the research of Rheumatoid arthritis .
  • HY-P990360

    Inhibitory Antibodies Inflammation/Immunology
    Anti-CD9 Antibody is a CHO expressed human antibody targeting CD9. Anti-CD9 Antibody has a huIgG1-type heavy chain and a huλ-type light chain, with a predicted molecular weight (MW) of 145.98 kDa. The isotype control for Anti-CD9 Antibody can be found in Human IgG1 kappa, Isotype Control (HY-P99001).
  • HY-P99242

    Inhibitory Antibodies Cancer
    Alsevalimab is a human monoclonal antibody against B7-H4 .
  • HY-P990023

    ADX-914

    Inhibitory Antibodies Inflammation/Immunology
    Bempikibart (ADX-914) is a human anti-IL-7Rα antibody. Bempikibart can be used for the research of anti-inflammatory .
  • HY-P9938

    CGRP Receptor Others
    Erenumab is a fully human monoclonal antibody. Erenumab inhibits the calcitonin gene–related peptide (CGRP) receptor. Erenumab can be used for the prevention of episodic migraine .
  • HY-P99271

    Anti-Human F3 Recombinant Antibody

    ADC Antibody Cancer
    Tisotumab (Anti-Human F3 Recombinant Antibody) is a human IgG1 monoclonal antibody targets tissue factor (TF). Tisotumab can be used for the research of solid tumors .
  • HY-P99514

    AGEN1884

    CTLA-4 Cancer
    Zalifrelimab (AGEN1884) is a fully human IgG1 monoclonal antibody targeting CTLA-4 (CTLA-4). Zalifrelimab antagonizes the inhibitory checkpoints of immune cell activation regulated by CTLA-4 signaling .
  • HY-P9908
    Adalimumab
    5+ Cited Publications

    Anti-Human TNF-alpha, Human Antibody

    TNF Receptor Bacterial Inflammation/Immunology Cancer
    Adalimumab is a human monoclonal IgG1 antibody targeting tumour necrosis factor α (TNF-α).
  • HY-P99057

    CDX-1127

    TNF Receptor Cancer
    Varlilumab (CDX-1127) is a first-in-class human IgG1 anti-CD27 monoclonal antibody. Varlilumab has an anti-tumor activity .
  • HY-P99474

    CAT 213; iCo-008

    CCR Inflammation/Immunology
    Bertilimumab (CAT 213; iCo-008) is a human monoclonal antibody targeting eotaxin-1 (CCL11). Bertilimumab has the potential for allergic disorders research .
  • HY-P99057A

    TNF Receptor Cancer
    Varlilumab (anti-CD27) is a first-in-class human IgG1 anti-CD27 monoclonal antibody. Varlilumab has an anti-tumor activity .
  • HY-P99040

    JNJ-61610588

    PD-1/PD-L1 Cancer
    Onvatilimab (JNJ-61610588) is a human IgG1κ anti-VISTA (V-domain Ig Suppressor of T-cell Activation) monoclonal antibody. Onvatilimab has an anti-tumor activity .
  • HY-P99266

    Anti-Human CD4 Recombinant Antibody

    Inhibitory Antibodies Inflammation/Immunology Cancer
    Zanolimumab (Anti-Human CD4 Recombinant Antibody) is a fully human monoclonal antibody targets CD4. Zanolimumab effectively inhibits T-cell receptor (TCR) signal transduction. Zanolimumab can be used for the research of heumatoid arthritis, psoriasis, melanoma, cutaneous and peripheral T-cell lymphoma .
  • HY-108730
    Avelumab
    5+ Cited Publications

    Anti-Human PD-L1, Human Antibody; MSB 0010718C; MSB0010718C

    PD-1/PD-L1 Inflammation/Immunology Cancer
    Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody with potential antibody-dependent cell-mediated cytotoxicity.
  • HY-P9909
    Ustekinumab
    1 Publications Verification

    Anti-Human IL-12/IL-23, Human Antibody

    Interleukin Related Inflammation/Immunology Cancer
    Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.
  • HY-P99263
    Inclacumab
    1 Publications Verification

    Anti-Human selectin P Recombinant Antibody

    P-selectin Cardiovascular Disease
    Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion .
  • HY-P9967

    BIIB037

    Amyloid-β Neurological Disease
    Aducanumab (BIIB037) is a human monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). Aducanumab shows brain penetration, and can be used for Alzheimer's disease (AD) research .
  • HY-P9915
    Daratumumab
    1 Publications Verification

    Anti-Human CD38, Human Antibody

    CD38 ADC Antibody Inflammation/Immunology Cancer
    Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .
  • HY-P99460

    BAY-1905254

    Inhibitory Antibodies Inflammation/Immunology Cancer
    Bapotulimab (BAY-1905254) is a fully human IgG2 antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2). Bapotulimab has antitumor and immunosuppressive effects .
  • HY-P99039

    MEDI9447

    CD73 Cancer
    Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity .
  • HY-P99424

    RG 7624; RO 5553110; NI-1401

    Interleukin Related Inflammation/Immunology
    Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody neutralizing both IL-17A and IL-17F. Afasevikumab has anti-inflammatory activities .
  • HY-P99179

    Inhibitory Antibodies Cancer
    CTX-2026 is a fully human antibody that binds to CD277. CTX-2026 shows an anti-tumor effect on ovarian tumor models. CTX-2026 can be used for the research of cancer .
  • HY-108810

    Ilaris; ACZ 885

    Interleukin Related Inflammation/Immunology Cancer
    Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin .
  • HY-P99275
    Patritumab
    1 Publications Verification

    Human Anti-ERBB3 Recombinant Antibody

    EGFR Akt ERK PARP Survivin Cancer
    Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors .
  • HY-P9915A
    Daratumumab (PBS)
    1 Publications Verification

    Anti-Human CD38, Human Antibody (PBS)

    ADC Antibody CD38 Cancer
    Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .
  • HY-P99262

    BAX69; Anti-Human MIF Recombinant Antibody

    Macrophage migration inhibitory factor (MIF) Cancer
    Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody that targets macrophage inhibitory factor (MIF). Imalumab can be used for the research of ovarian carcinoma, recurrent malignant ascites and cancer .
  • HY-P99288

    Pamrevlumab; Anti-Human CTGF Recombinant Antibody

    Apoptosis Cancer
    FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF) .
  • HY-P99307

    AMG-203; Anti-Human CSF2 Recombinant Antibody

    c-Fms Inflammation/Immunology
    Namilumab (AMG203) is a human IgG1 monoclonal antibody that binds with high affinity to the GM-CSF ligand, potently neutralizing GM-CSF. Namilumab can be used for the research of rheumatoid arthritis .
  • HY-P9974

    OMP-18R5

    Wnt Cancer
    Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to FZD1/2/5/7/8 receptors. Vantictumab can be studied against cancers through direct actions on tumor cells, including CSCs, and effects on the stroma, such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma .
  • HY-P99041
    Panitumumab
    1 Publications Verification

    ABX-EGF

    EGFR Cancer
    Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer .
  • HY-P99274
    Xentuzumab
    1 Publications Verification

    BI 836845; Anti-Human IGF1 and IGF2 Recombinant Antibody

    IGF-1R Cancer
    Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation .
  • HY-P990100

    Inhibitory Antibodies Inflammation/Immunology
    Human IgG1 (E356D/M358L) kappa, Isotype Control, a human-derived monoclonal antibody, is an isotype control for human IgG1(E356D/M358L)κ antibody .
  • HY-P99323

    BTT 1023; Anti-Human AOC3 Recombinant Antibody

    VAP-1 Inflammation/Immunology
    Timolumab (BTT1023 ), a recombinant fully human monoclonal antibody that specifically binds VAP-1. Timolumab (BTT1023 ) could be used in the study of chronic inflammatory diseases .
  • HY-P99320

    OMP 59R5; Anti-Human NOTCH2 Recombinant Antibody

    Notch Cancer
    Tarextumab (OMP-59R5) is an anti-Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab shows anti-tumor activity .
  • HY-P99041A

    EGFR Cancer
    Panitumumab (anti-EGFR) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab (anti-EGFR) inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab (anti-EGFR) can be used in the research of cancers, such as colon cancer .
  • HY-P99184

    Integrin Infection Inflammation/Immunology Cancer
    Abrilumab is a fully human monoclonal antibody directed against α4β7. Abrilumab selectively binds the α4β7 integrin heterodimer. Abrilumab can be used for the research of inflammatory bowel disease (IBD) .
  • HY-P99318

    LT 1009; Anti-Human S1P Recombinant Antibody

    LPL Receptor Cancer
    Sonepcizumab (LT 1009) is a fully human anti-S1P monoclonal antibody. Sonepcizumab has the potential for the research of metastatic renal cell carcinoma (mRCC) .
  • HY-P9957

    ABthrax

    Bacterial Infection
    Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research .
  • HY-P99322

    LFG316; Anti-Human C5 Recombinant Antibody

    Complement System Inflammation/Immunology
    Tesidolumab (LFG316) is a fully-human IgG1/λ anti-C5 monoclonal antibody of 143 kDa (without glycosylation). Tesidolumab (LFG316) blocks cleavage of C5 and prevents subsequent formation of the membrane attack complex .
  • HY-P99257

    ASKP 1240; Anti-Human CD40 Recombinant Antibody

    Inhibitory Antibodies Inflammation/Immunology
    Bleselumab (ASKP 1240) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab binds to human CD40 with high affinity (Kd: ?0.24?nM). Bleselumab inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab prevents organ transplant rejection .
  • HY-P99272

    BMS 936564; MDX 1338; Anti-Human CXCR4 Recombinant Antibody

    CXCR Cancer
    Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models .
  • HY-P99265

    HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody

    Inhibitory Antibodies Cancer
    Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that targets tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). Mapatumumab can be used for the research of cancer .
  • HY-P99286

    PRO 95780; rhuMAb-DR 5; Anti-Human DR5 Recombinant Antibody

    Apoptosis Cancer
    Drozitumab (PRO 95780) is a human agonistic monoclonal antibody which binds the death receptor DR5. Drozitumab has potent antitumor activity against rhabdomyosarcoma .
  • HY-P99294

    AMG 479; Human Anti-IGF1R Recombinant Antibody

    IGF-1R Cancer
    Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .
  • HY-P99324

    Anti-Human EGFR Recombinant Antibody

    EGFR Apoptosis Cancer
    Tomuzotuximab (Anti-Human EGFR Recombinant Antibody) is a fully human glycoengineered IgG1 monoclonal antibody against EGFR. Tomuzotuximab has anticancer effects .
  • HY-P99260

    AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody

    TNF Receptor Cancer
    Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. .
  • HY-P99246

    MABp1

    Interleukin Related Inflammation/Immunology Cancer
    Bermekimab (MABp1) is a human monoclonal antibody that targets interleukin-1alpa (IL-1α). Bermekimab prevents tumour-related inflammation .
  • HY-111965

    anti-EFNA4-ADC

    Inhibitory Antibodies Inflammation/Immunology
  • HY-P990317

    Inhibitory Antibodies Inflammation/Immunology

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