1. Gene
  2. Egfr - epidermal growth factor receptor Gene

Egfr - epidermal growth factor receptor Gene

Mus musculus

Also known as Wa5; wa2; Erbb; Errp; wa-2; Errb1; 9030024J15Rik

Gene ID: 13649 | Gene type: protein coding

About Egfr

Chromosome 11: 16,702,203-16,868,158 forward strand.GRCm39:CM001004.3

This gene has 5 transcripts (splice variants), 283 orthologues, 53 paralogues and is associated with 180 phenotypes. Broad expression in liver adult (RPKM 26.7), liver E18 (RPKM 8.7) and 15 other tissues.

Summary

Enables epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Involved in cellular response to amino acid stimulus and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; epidermal growth factor receptor signaling pathway; and protein autophosphorylation. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and respiratory system. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

Egfr Products(2)

mRNA Protein Name
NM_207655.2 NP_997538.1 epidermal growth factor receptor isoform 1 precursor
NM_007912.4 NP_031938.1 epidermal growth factor receptor isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables epidermal growth factor binding IDA
IDA: Inferred from direct assay
7678348 MGI
enables epidermal growth factor receptor activity IDA
IDA: Inferred from direct assay
6248866 MGI
enables epidermal growth factor receptor activity IGI
IGI: Inferred from genetic interaction
16357442 MGI
enables epidermal growth factor receptor activity IMP
IMP: Inferred from mutant phenotype
18701712 MGI
enables kinase activity IDA
IDA: Inferred from direct assay
12808090 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11274221 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
15383614 MGI
enables protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
11823423 MGI
enables transmembrane receptor protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
7752576 MGI
enables transmembrane receptor protein tyrosine kinase activity IGI
IGI: Inferred from genetic interaction
28783046 MGI
enables transmembrane receptor protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
12399441 MGI
Biological Process GO Annotation Evidence Reference Source
involved in ERBB2-EGFR signaling pathway IDA
IDA: Inferred from direct assay
8702723 MGI
involved in ERBB2-EGFR signaling pathway IMP
IMP: Inferred from mutant phenotype
18701712 MGI
acts upstream of or within cell morphogenesis IGI
IGI: Inferred from genetic interaction
17686994 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
18656477 MGI
involved in cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
22711986 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
8702723 MGI
acts upstream of or within cerebral cortex cell migration IMP
IMP: Inferred from mutant phenotype
7618084 MGI
acts upstream of or within digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
7618084 MGI
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
7618084 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
14712229 MGI
involved in epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
6248866 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
7641815 MGI
involved in epidermal growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
28783046 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17686994 MGI
involved in epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12399441 MGI
acts upstream of or within epidermis development IMP
IMP: Inferred from mutant phenotype
7618084 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
7618084 MGI
acts upstream of or within eyelid development in camera-type eye IGI
IGI: Inferred from genetic interaction
9030684 MGI
acts upstream of or within hair follicle development IGI
IGI: Inferred from genetic interaction
9030684 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
7618084 MGI
acts upstream of or within morphogenesis of an epithelial fold IMP
IMP: Inferred from mutant phenotype
7618084 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
23457600 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11823423 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
14712229 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
7641815 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
7618084 MGI
involved in positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
20208556 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
15314156 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
11818567 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
11940581 MGI
acts upstream of or within salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
10521784 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
11940581 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
7723235 MGI
located in cell surface IDA
IDA: Inferred from direct assay
23918928 MGI
located in endocytic vesicle IDA
IDA: Inferred from direct assay
10534613 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
10534613 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20208556 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
20208556 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
6248866 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
7641815 MGI
is active in plasma membrane IGI
IGI: Inferred from genetic interaction
28783046 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Egfr Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (56 - 167)

Furin-like

Furin-like: pfam00757 (183 - 334)

Recep_L_domain

Recep_L_domain: pfam01030 (361 - 480)

GF_recep_IV

GF_recep_IV: pfam14843 (504 - 635)

TM_ErbB1

TM_ErbB1: cd12093 (633 - 678)

PTKc_EGFR

PTKc_EGFR: cd05108 (705 - 1017)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1210 a.a.
Protein Preferred Names Protein Names

epidermal growth factor receptor

avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

waved 2

Recombinant Egfr Proteins

Cat. No. Product Name Accession Purity
HY-P72988 EGFR Protein, Mouse (HEK293, Fc) Q01279 (L25-S647) ≥95%
HY-P72989 EGFR Protein, Mouse (HEK293, His) Q01279 (L25-S647) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Egfr NCBI NCBI:1956
Canis familiaris Egfr NCBI NCBI:404306
Macaca fascicularis Egfr NCBI NCBI:102138724
Rattus norvegicus Egfr NCBI NCBI:24329
Macaca mulatta Egfr NCBI NCBI:613027