Search Result

Results for "

prostate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PSMA (26) 17β-HSD (2) 5 alpha Reductase (14) Acyltransferase (1) ADC Cytotoxin (1) ADC Linker (3) Adenosine Receptor (1) Adenylate Cyclase (2) Adrenergic Receptor (41) Akt (14) Aldehyde Dehydrogenase (ALDH) (5) Aldose Reductase (8) Amino Acid Derivatives (1) AMPK (4) Androgen Receptor (108) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (4) Apelin Receptor (APJ) (1) Apoptosis (142) Arrestin (1) Aryl Hydrocarbon Receptor (1) Atg4 (1) Atg8/LC3 (1) ATM/ATR (1) ATP Synthase (1) Aurora Kinase (1) Autophagy (27) Bacterial (12) Bcl-2 Family (9) Bcr-Abl (4) Biochemical Assay Reagents (3) Bradykinin Receptor (1) c-Fms (1) c-Kit (1) c-Met/HGFR (1) c-Myc (4) Cannabinoid Receptor (2) Carbonic Anhydrase (1) Carboxypeptidase (1) Caspase (15) Cathepsin (2) CCR (1) CD3 (2) CDK (10) Ceramidase (1) CGRP Receptor (1) Checkpoint Kinase (Chk) (1) Chloride Channel (1) Complement System (1) COX (2) CTLA-4 (1) CXCR (2) Cytochrome P450 (9) Dengue virus (1) DNA Alkylator/Crosslinker (1) DNA-PK (2) DNA/RNA Synthesis (4) Drug Metabolite (5) Drug-Linker Conjugates for ADC (5) DYRK (2) E1/E2/E3 Enzyme (2) EGFR (4) Elastase (1) Endogenous Metabolite (24) Endothelin Receptor (1) Epigenetic Reader Domain (28) Estrogen Receptor/ERR (8) Farnesyl Transferase (2) Fat Mass and Obesity-associated Protein (FTO) (2) Fatty Acid Synthase (FASN) (8) FGFR (1) Flavivirus (1) Fluorescent Dye (2) Fungal (6) FXR (4) Gap Junction Protein (2) Glucocorticoid Receptor (1) Glucosidase (3) Glutathione Peroxidase (1) Glutathione S-transferase (1) GnRH Receptor (22) GSK-3 (2) HBV (2) HDAC (10) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (3) Histamine Receptor (1) Histone Acetyltransferase (13) Histone Demethylase (12) Histone Methyltransferase (11) HIV (7) HPV (1) HSP (4) HSV (1) IAP (3) ICMT (1) IGF-1R (1) Influenza Virus (4) Insulin Receptor (1) Integrin (2) Interleukin Related (2) IRE1 (1) Isotope-Labeled Compounds (17) JAK (1) Kisspeptin Receptor (3) Ligands for E3 Ligase (4) Ligands for Target Protein for PROTAC (5) Lipoxygenase (4) LPL Receptor (1) MAPKAPK2 (MK2) (1) MDM-2/p53 (4) METTL3 (2) MicroRNA (1) Microtubule/Tubulin (13) Mitophagy (1) MMP (3) MNK (1) Molecular Glues (2) Monoamine Oxidase (4) mTOR (7) Necroptosis (1) Neurokinin Receptor (1) NF-κB (7) NO Synthase (1) Notch (1) Nuclear Factor of activated T Cells (NFAT) (1) Organoid (4) P-glycoprotein (2) p38 MAPK (2) Paraptosis (1) Parasite (3) PARP (11) PD-1/PD-L1 (1) PDK-1 (1) PGE synthase (1) Phosphatase (6) Phosphodiesterase (PDE) (3) Phospholipase (2) PI3K (9) PIKfyve (1) Pim (4) PKC (4) Platelet-activating Factor Receptor (PAFR) (1) Polo-like Kinase (PLK) (3) Potassium Channel (1) PPAR (5) Progesterone Receptor (6) Prostaglandin Receptor (3) PROTAC Linkers (2) PROTAC-Linker Conjugates for PAC (3) PROTACs (37) Protease Activated Receptor (PAR) (1) Proteasome (1) Pyruvate Kinase (2) Radionuclide-Drug Conjugates (RDCs) (4) Raf (3) RAR/RXR (1) Ras (7) Reactive Oxygen Species (11) Reverse Transcriptase (6) ROCK (2) ROR (3) ROS Kinase (1) SARS-CoV (6) Ser/Thr Protease (1) Serotonin Transporter (4) SHP2 (3) Sirtuin (3) SOD (1) Src (5) STAT (5) Survivin (1) Telomerase (6) TNF Receptor (2) Toll-like Receptor (TLR) (2) Topoisomerase (8) TRP Channel (4) VD/VDR (1) VEGFR (9) Virus Protease (1) VSV (1) Wnt (2)
By Research Areas:	Cancer (628) Cardiovascular Disease (30) Endocrinology (86) Infection (38) Inflammation/Immunology (51) Metabolic Disease (33) Neurological Disease (19)
Click Chemistry:	Alkynes (4)
Oligonucleotides:	Aptamers (2) Cholesterol (2)

699

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: PSMA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-NP017

Prostate specific antigen protein (human) PSA; Native human prostate specific antigen protein	Prostaglandin Receptor	Endocrinology
Prostate specific antigen protein (human) is a serine protease which produced by prostatic epithelium. Prostate specific antigen protein (human) can be used to study prostatic cancer .

HY-P5990

Prostate Specific Antigen Substrate	PSMA	Cancer
Prostate Specific Antigen Substrate is a prostate specific antigen (PSA) fluorescent substrate. Prostate Specific Antigen Substrate can be used for detect enzymatic activity of PSA .

HY-N8856

Angelol M	Others	Others
Angelol M,isolated from the roots of Angelica gigas Nakai, shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells .

HY-164395

Sipuleucel-T	Phosphatase	Inflammation/Immunology Cancer
Sipuleucel-T is a cancer vaccine. Sipuleucel-T recognizes prostatic acid phosphatase (PAP), present PAP antigens, and stimulates the immune response against prostate cancer cells .

HY-167878

Pentomone LY-113935	Androgen Receptor	Endocrinology
Pentomone (LY-113935), an antiandrogen compound, is a prostate growth inhibitor .

HY-105164

Topixantrone BBR 3576	Others	Cancer
Topixantrone (BBR 3576) is an antitumor agent, and shows antitumor activity on prostate carcinoma .

HY-105164A

Topixantrone dihydrochloride BBR 3576 dihydrochloride	Others	Cancer
Topixantrone (BBR 3576) dihydrochloride is an antitumor agent, and shows antitumor activity on prostate carcinoma .

HY-118091A

Bexlosteride LY300502	Others	Cancer
Bexlosteride (LY300502) is a benzoquinolinone human type I 5α-reductase inhibitor. Bexlosteride shows metabolic inhibitory, antiproliferative, and antisecretory effects in LNCaP human prostatic adenocarcinoma cell cultures. Bexlosteride can be used for the research of prostatic cancer .

HY-105217

Turosteride FCE 26073	5 alpha Reductase	Metabolic Disease
Turosteride is a selective 5 alpha-reductase inhibitor, with IC₅₀ values of 55 and 53 nM for human and rat prostatic 5 alpha-reductases, respectively. Turosteride can reduce the prostate and seminal vesicle weights .

HY-P2450

Leucinostatin A Antibiotic P168	Fungal Antibiotic	Infection Cancer
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies .

HY-129615

MIP-1072	PSMA	Cancer
MIP-1072 is a small molecule specific prostate-specific membrane antigen (PSMA) inhibitor. MIP-1072 inhibits the glutamate carboxypeptidase activity of PSMA with an K_i value of 4.6 nM. MIP-1072 is promising for research of prostate cancer .

HY-N8850

Angelol G	Others	Cancer
Angelol G, a coumarin, can be isolated from Campylotropis hirtella. Angelol G shows inhibitory activity for prostate specific antigen (PSA)IC₅₀ value of 152.1μM. Angelol G can be used for the research of benign prostate hyperplasia (BPH) .

HY-130574

MnTE-2-PyP chloride BMX-010 chloride	Reactive Oxygen Species	Cancer
MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer .

HY-N10491

Spongionellol A	P-glycoprotein	Cancer
Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A can be used in the research of cancers, such as prostate cancer .

HY-14249

Bicalutamide 10+ Cited Publications	Androgen Receptor Autophagy	Cancer
Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer .

HY-B0192A

Alfuzosin hydrochloride 1 Publications Verification SL 77499-10	Adrenergic Receptor	Endocrinology
Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH) .

HY-B0192

Alfuzosin 1 Publications Verification SL 77499	Adrenergic Receptor	Endocrinology
Alfuzosin (SL 77499-10) is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH) .

HY-106138

Avorelin Meterelin; MF 6001	GnRH Receptor	Cancer
Avorelin (Meterelin) is a gonadotropin releasing hormone (GnRH) agonist. Avorelin can be used of the study of prostate cancer .

HY-P5290

HYNIC-PSMA	PSMA	Cancer
HYNIC-PSMA is a ligand for molecular imaging of tumors. Hynic-psma consists of two components: HYNIC (6-hydrazinonicotinamide) and PSMA (Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules, such as ¹⁸⁸Re-HYNIC-PSMA. PSMA is a membrane antigen that is specifically expressed on the surface of prostate cancer cells. HYNIC-PSMA can be used in prostate cancer research .

HY-136383

AZA1 1 Publications Verification Rac1/Cdc42-IN-1	Ras Apoptosis	Cancer
AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion .

HY-P99239

Rosopatamab HUJ-591	PSMA Radionuclide-Drug Conjugates (RDCs)	Cancer
Rosopatamab (HuJ591) is a humanized antiPSMA IgG1 monoclonal antibody that can be used in cancer research, especially prostate cancer. Rosopatamab can be linked to the low-energy beta-emitting radioisotope lutetium-177 ( ¹⁷⁷Lu) through the bifunctional chelator DOTA-NHS ester to obtain a radioimmunoconjugate that targets malignant prostate cells with high efficiency .

HY-W013272

Hydroxyflutamide HFT	Androgen Receptor	Cancer
Hydroxyflutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist (IC₅₀=700 nM). Hydroxyflutamide can be used for the research of prostate cancer .

HY-N7924

Astragenol	Others	Inflammation/Immunology Cancer
Astragenol is an intermediate used for Astragenol derivative synthesis. Astragenol derivatives are promising anti-inflammatory agents for prostate cancer research .

HY-110154

NSC636819	Histone Demethylase	Cancer
NSC636819 is a competitive and selective inhibitor of KDM4A/KDM4B. KDM4A/KDM4B are potential progression factors for prostate cancer. NSC636819 has the potential for the research of cancer diseases, especially prostate cancer .

HY-P1442

AdTx1	Adrenergic Receptor	Cancer
AdTx1 is a selective α1A-adrenoceptor antagonist (K_i: 0.35 nM). AdTx1 can be used for research of benign prostatic hyperplasia .

HY-70002

Enzalutamide 150+ Cited Publications MDV3100	Androgen Receptor Autophagy	Cancer
Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC₅₀ of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator .

HY-P99188

Carlumab 1 Publications Verification CNTO 888	CCR	Cancer
Carlumab (CNTO 888) is a human anti-CCL2 (chemokine ligand 2) antibody with high affinity. Carlumab can be used in cancer research, particularly in prostate cancer .

HY-138641

Bavdegalutamide 3 Publications Verification ARV-110	PROTACs Androgen Receptor	Cancer
Bavdegalutamide (ARV-110) is an orally active, specific androgen receptor (AR) PROTAC degrader. Bavdegalutamide promotes ubiquitination and degradation of AR. Bavdegalutamide can be used for the research of prostate cancer .

HY-153772

Androgen receptor antagonist 8	Androgen Receptor	Cancer
Androgen receptor antagonist 8 (Example 13) is an androgen receptor antagonist. Androgen receptor antagonist 8 inhibits prostate specific antigen secretion in LNcap cell (IC₅₀: 88 nM). Androgen receptor antagonist 8 can be used for prostate cancer research .

HY-B0192AR

Alfuzosin hydrochloride (Standard)	Adrenergic Receptor	Endocrinology
Alfuzosin (hydrochloride) (Standard) is the analytical standard of Alfuzosin (hydrochloride). This product is intended for research and analytical applications. Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH) .

HY-N10492

Spongionellol A analog 1	P-glycoprotein	Cancer
Spongionellol A analog 1, an analog of Spongionellol A (HY-10491), is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A analog 1 has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A analog 1 can be used in the research of cancers, such as prostate cancer .

HY-163610

AKR1C3-IN-13	Ligands for Target Protein for PROTAC Aldose Reductase	Cancer
AKR1C3-IN-13 (Compound 4) is an AKR1C3 inhibitor. AKR1C3-IN-13 degrades AKR1C3 in prostate cancer cells .

HY-119001

BKM1644	Others	Cancer
BKM1644, an acyl-tyrosine bisphosphonate amide derivative, exhibits potent anti-cancer activity. BKM1644 effectively inhibits the proliferation of metastatic, castration-resistant prostate cance (mCRPC) cells. BKM1644 sensitizes mCRPC cells to Docetaxel (HY-B0011) and retards the bone metastatic growth of prostate cance .

HY-105173

Teverelix EP 24332	GnRH Receptor Histamine Receptor	Endocrinology Cancer
Teverelix (EP 24332) is a GnRH antagonist. Teverelix binds competitively and reversibly to GnRH receptors, thereby suppressing the release of LH and FSH. Teverelix can be used in the research of prostatic hyperplasia, endometriosis, and prostate cancer .

HY-P0013

Antide D-21074; ORF 23541	GnRH Receptor	Cancer
Antide (D-21074) is a potent LHRH antagonist. Antide also can be used for the research of prostatic cancer.

HY-101826A

ER21355 hydrochloride	Phosphodiesterase (PDE)	Cancer
ER21355 hydrochloride is the hydrochloride form of ER21355 (HY-101826). ER21355 hydrochloride is an inhibitor for phosphodiesterase (PDE), which is potent for ameliorating benign prostatic hyperplasia (BPH) and prostatism through increasing levels of cAMP and cGMP, and resulting a relaxation of the smooth muscle cell .

HY-162686

MYC-IN-3	c-Myc	Cancer
MYC-IN-3 (compound 37) is a potent MYC inhibitor. MYC-IN-3 shows antiproliferative activity. MYC-IN-3 shows anticancer activity. MYC-IN-3 has the potential for the research of prostate cancer .

HY-14249R

Bicalutamide (Standard)	Androgen Receptor Autophagy	Cancer
Bicalutamide (Standard) is the analytical standard of Bicalutamide. This product is intended for research and analytical applications. Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer .

HY-14249S1

Bicalutamide-d5	Androgen Receptor Autophagy Isotope-Labeled Compounds	Cancer
Bicalutamide-d₅ is deuterated labeled Bicalutamide (HY-14249). Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer .

HY-P3501

Fexapotide NX-1207 free acid	Apoptosis	Cancer
Fexapotide (NX-1207 free acid) induces apoptosis selectively, reducing prostate volume at a cellular level. Fexapotide can be used in lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) research .

HY-P3501A

Fexapotide TFA NX-1207 TFA	Apoptosis	Cancer
Fexapotide (NX-1207) TFA induces apoptosis selectively, reducing prostate volume at a cellular level. Fexapotide can be used in lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) research .

HY-164477

FL442	Androgen Receptor	Cancer
FL442 is an Androgen Receptor (AR) modulator. FL442 exhibits strong inhibitory effects in AR-dependent prostate cancer cells, showing similar inhibitory efficiency to traditional antiandrogen drugs Bicalutamide (HY-14249) and Enzalutamide (HY-70002), while maintaining antiandrogenic activity against the AR mutant F876L, which is highly resistant to Enzalutamide. Pharmacokinetic studies of FL442 in mice reveal a long half-life (8 hours), good targeting (prostate tissue), and metabolic stability, and it effectively inhibits LNCaP tumor growth at low plasma concentrations (30 ng/mL) .

HY-164807

SARD279	Androgen Receptor	Cancer
SARD279 is a potent and selective Androgen Receptor degrader with DC₅₀ value of 1099 nM. SARD279 can be used in prostate cancer research .

HY-124292

Honokiol DCA 1 Publications Verification Honokiol dichloroacetate	Androgen Receptor	Cancer
Honokiol DCA (Honokiol dichloroacetate) is a dichloroacetate analog of Honokiol. Honokiol DCA can inhibit the growth of human prostate cancer cells in vitro and suppress the androgen receptor (AR) protein level .

HY-W013272R

Hydroxyflutamide (Standard)	Androgen Receptor	Cancer
Hydroxyflutamide (Standard) is the analytical standard of Hydroxyflutamide. This product is intended for research and analytical applications. Hydroxyflutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist (IC50=700 nM). Hydroxyflutamide can be used for the research of prostate cancer .

HY-B0391B

Naftopidil hydrochloride KT-611 hydrochloride; BM-15275 hydrochloride	Adrenergic Receptor	Cancer
Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with K_is of 3.7 nM, 20 nM and 1.2 nM for the cloned human α_1a-, α_1b- and α_1d-adrenoceptor subtypes, respectively. Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia .

HY-78884

Anticancer agent 9	Amino Acid Derivatives	Cancer
Anticancer agent 9, a glycine derivative, is an anticancer agent. Anticancer agent 9 can inhibit tumor cells viability of myelogenous leukemia and human prostate cancer .

HY-70002S1

Enzalutamide-d6 MDV3100-d₆	Androgen Receptor	Cancer
Enzalutamide-d₆ is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells[1].

HY-16498

Tigapotide PCK-3145	Apoptosis	Cancer
Tigapotide (PCK-3145) is an anti-tumour peptide that reduces the development of skeletal metastases associated with prostate cancer. Tigapotide induces apoptosis and reduces tumour parathyroid hormone-related peptide (PTHrP) levels .

HY-125399

PSMA-11 HBED-CC-PSMA	PSMA Radionuclide-Drug Conjugates (RDCs)	Cancer
PSMA-11 is a small molecule ligand that targets prostate-specific membrane antigen (PSMA) and has the ability to inhibit PSMA activity. PSMA-11 can be used to synthesize ⁶⁸Ga-PSMA-11, a positron emission tomography (PET) tracer that can be used to image advanced prostate cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7924

Astragenol	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	Others
Astragenol is an intermediate used for Astragenol derivative synthesis. Astragenol derivatives are promising anti-inflammatory agents for prostate cancer research .

HY-N3999

Venuloside A ESK246	Structural Classification Other Monoterpenes Terpenoids Source classification Pittosporaceae Plants Pittosporum venulosum F.Muell.	Others
Venuloside A is a potent inhibitor of LAT3. Venuloside A inhibits the leucine uptake in LNCaP prostate cancer cells with an IC₅₀ of 8.12 μM .

HY-N8856

Angelol M	Structural Classification Leguminosae Campylotropis hirtella (Franch.) Schindl. Source classification Coumarins Phenylpropanoids Plants	Others
Angelol M,isolated from the roots of Angelica gigas Nakai, shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells .

HY-P2450

Leucinostatin A Antibiotic P168	Infection Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Fungal Antibiotic
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies .

HY-N8850

Angelol G	Structural Classification Leguminosae Campylotropis hirtella (Franch.) Schindl. Source classification Coumarins Phenylpropanoids Plants	Others
Angelol G, a coumarin, can be isolated from Campylotropis hirtella. Angelol G shows inhibitory activity for prostate specific antigen (PSA)IC₅₀ value of 152.1μM. Angelol G can be used for the research of benign prostate hyperplasia (BPH) .

HY-N10491

Spongionellol A	Microorganisms Source classification Diterpenoids	P-glycoprotein
Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A can be used in the research of cancers, such as prostate cancer .

HY-N10492

Spongionellol A analog 1	Microorganisms Source classification Diterpenoids	P-glycoprotein
Spongionellol A analog 1, an analog of Spongionellol A (HY-10491), is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A analog 1 has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A analog 1 can be used in the research of cancers, such as prostate cancer .

HY-N10265

Stephacidin B	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Alkaloid Dimers Cancer	Endogenous Metabolite
Stephacidin B is a fungal metabolite. Stephacidin B shows in vitro cytotoxicity against a panel of human tumor cell lines. Stephacidin B shows the strongest cytotoxicity against testosterone-dependent prostate LNCaP cancer cells .

HY-N7569

Demethoxyfumitremorgin C	Structural Classification Alkaloids Microorganisms Source classification Marine natural products Other marine organisms Indole Alkaloids	Apoptosis Caspase PPAR
Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates caspase-3, -8, and -9, leading to PARP/ cleavage .

HY-126412

Neochamaejasmine A	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones	Apoptosis
Neochamaejasmine A is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L.. Neochamaejasmine A inhibits proliferation, induces cell cycle arrest and apoptosis in tumor cells. Neochamaejasmine A can be used in the research of cancers such as prostate cancer, hepatoma cancer .

HY-N6601

Pomolic acid Randialic acid A	Triterpenes Structural Classification Euscaphis japonica other families Staphyleaceae Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from?Euscaphis japonica?(Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC) .

HY-122108

Ilicicolin A LL-Z 1272-alpha	Structural Classification Microorganisms Source classification Phenols Polyphenols	Apoptosis
Ilicicolin A is a potent anticancer agent. Ilicicolin A induces apoptosis. Ilicicolin A inhibits cell growth and colony formation. Ilicicolin A shows antitumor activity. Ilicicolin A has the potential for the research of prostate cancer .

HY-N2908

Atraric acid Methyl atrarate	Structural Classification Microorganisms Classification of Application Fields Phenols Essence, Fragrance Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Cancer	Androgen Receptor NO Synthase p38 MAPK NF-κB
Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases .

HY-N2059

Santalol	Structural Classification other families Classification of Application Fields Santalum album Linn. Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields Santalaceae Cancer	Others
Santalol is a mixture of α and β-isomer santalol. α-santalol is isolated from sandalwood oil. α-santalol is a promising anti-cancer agent against cancers such as oral, breast, prostate and skin cancer .

HY-N13195

(15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	5 alpha Reductase
(15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one shows a 5a-reductase inhibitory activity with an IC₅₀ value of 41.9 μM. (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one inhibits the growth of the ventral prostate induced by testosterone in rat. (15α)-15,26-Dihydroxylanosta-7,9(11),24-trien-3-one is promising for research of benign prostatic hyperplasia (BPH) as well as other 5α-dihydrotestosterone (DHT)-related disorders, such as acne and male pattern baldness .

HY-B0661

Tamsulosin (R)-(-)-YM12617 free base; LY253351 free base	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Endocrinology Cancer	Adrenergic Receptor Endogenous Metabolite
Tamsulosin ((R)-(-)-YM12617 free base) is an inhibitor of α₁-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models .

HY-B1150

Clofoctol	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Infection Monophenols Microorganisms Antibiotics Phenols Antiviral Anticancer Disease Research Fields	Bacterial SARS-CoV Antibiotic
Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency .

HY-B0371

Terazosin	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor
Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment .

HY-B1150R

Clofoctol (Standard)	Structural Classification Monophenols Microorganisms Antibiotics Source classification Phenols Antiviral Antibacterial Disease Research Anticancer Other Antibiotics	Bacterial SARS-CoV Antibiotic
Clofoctol (Standard) is the analytical standard of Clofoctol. This product is intended for research and analytical applications. Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency .

HY-B0661R

Tamsulosin (Standard)	Structural Classification Alkaloids Other Alkaloids Source classification Endogenous metabolite	Adrenergic Receptor Endogenous Metabolite
Tamsulosin (Standard) is the analytical standard of Tamsulosin. This product is intended for research and analytical applications. Tamsulosin ((R)-(-)-YM12617 free base) is an inhibitor of α₁-adrenergic receptor. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth in animal models .

HY-114319

β-Cembrenediol	Structural Classification Nicotiana tabacum L. Terpenoids Source classification Diterpenoids Solanaceae Plants	Others
β-Cembrenediol is a potent and orally active anticancer agent. β-Cembrenediol shows phytotoxic activities. β-Cembrenediol reduces the migration and colony formation. β-Cembrenediol decreases the protein expression of TDO2, IDO1. β-Cembrenediol has the potential for the research of prostate cancer .

HY-127057

Lambertianic acid	Pinus lambertiana Douglas Structural Classification Pinaceae Terpenoids Source classification Diterpenoids Plants	Androgen Receptor CDK MDM-2/p53 Apoptosis Caspase PARP Bcl-2 Family
Lambertianic acid is a bioactive diterpene with anti-allergic, antibacterial and anticancer activities. Lambertianic acid decreases androgen receptor protein levels, cellular and secretory levels of prostate-specific antigen. Lambertianic acid also suppresses cell proliferation by inducing G1 arrest, downregulating CDK4/6 and cyclin D1, activating p53, p21 and p27. Lambertianic acid induces Apoptosis and the expression of related proteins, including cleaved caspase-3/9, c-PARP and BAX, and inhibited BCl-2. Lambertianic acid is promising for research of prostate cancer .

HY-N3816

ent-17-Hydroxykaur-15-en-19-oic acid	Structural Classification Terpenoids Source classification Diterpenoids Laetia thamnia L. Plants Salicaceae	Others
ent-17-Hydroxykaur-15-en-19-oic acid is a ent-kaurene diterpene that can be isolated from the leaves of Laetia thamnia L.. ent-17-Hydroxykaur-15-en-19-oic acid was cytotoxic to human prostate LNCaP2 cells with IC₅₀ 17.63 mg/mL .

HY-17473

Embelin 4 Publications Verification Embelic acid; Emberine; NSC 91874	Quinones Structural Classification Classification of Application Fields Source classification Benzene Quinones Embelia laeta (Linn.) Mez Plants Myrsinaceae Disease Research Fields Cancer	IAP NF-κB Apoptosis Autophagy
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC₅₀=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells .

HY-N0551

Wedelolactone 15+ Cited Publications	Structural Classification Classification of Application Fields Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	Caspase Lipoxygenase Apoptosis
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-N1050

Zederone	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Curcuma elata Roxb. Zingiberaceae	mTOR
Zederone, a germacrane-type sesquiterpene, has potently cytotoxic against human white blood cancer cells and human prostate cancer cells. Zederone significantly inhibits the proliferation and downregulates the protein expressions of mTOR, and phosphorylated p70 S6 kinase (p-p70s6K) in SKOV3 cells .

HY-N0551R

Wedelolactone (Standard)	Structural Classification Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae	Caspase Lipoxygenase Apoptosis
Wedelolactone (Standard) is the analytical standard of Wedelolactone. This product is intended for research and analytical applications. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-17473R

Embelin (Standard)	Quinones Structural Classification Source classification Benzene Quinones Embelia laeta (Linn.) Mez Plants Myrsinaceae	IAP NF-κB Apoptosis Autophagy
Embelin (Standard) is the analytical standard of Embelin. This product is intended for research and analytical applications. Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells .

HY-N0790

Lupeol 3 Publications Verification Clerodol; Monogynol B; Fagarasterol	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Androgen Receptor Apoptosis
Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent androgen receptor (AR) inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) .

HY-121619

Jacaric acid	Structural Classification Caprifoliaceae Ketones, Aldehydes, Acids Source classification Plants Centranthus ruber (L.) DC	Apoptosis
Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC₅₀ is 11.8 μM), LNCaP (IC₅₀ is 2.2 μM) and DLD-1, induces apoptosis and necrosis . Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma . Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator . Jacaric acid is orally active.

HY-W748509

Pipernonaline	Piper longum Linn. Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants	Caspase Apoptosis
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-N10361

Drupanin	Monophenols Animals Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	RAR/RXR PPAR Aldose Reductase
Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC₅₀ value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers .

HY-N0790R

Lupeol (Standard)	Triterpenes Structural Classification other families Terpenoids Source classification Plants	Androgen Receptor Apoptosis
Lupeol (Standard) is the analytical standard of Lupeol. This product is intended for research and analytical applications. Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic?triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor (AR)?inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) .

HY-N0058

4,5-Dicaffeoylquinic acid 5 Publications Verification Isochlorogenic acid C	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Bowdichia virgilioides Plants Compositae Endogenous metabolite Disease Research Fields	HBV Endogenous Metabolite Apoptosis Glucosidase
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

HY-113289

Brassicasterol	Infection Animals Classification of Application Fields Source classification Disease Research Fields Steroids Cancer	Akt Androgen Receptor Bacterial Drug Metabolite HSV
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

HY-N0288

Lycorine 10+ Cited Publications	Alkaloids Structural Classification other families Pyrrole Alkaloids Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Amaryllidaceae	Fatty Acid Synthase (FASN) Virus Protease Bacterial Apoptosis
Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a K_d value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription . Lycorine is also a melanoma vasculogenic inhibitor . Lycorine can be used for the study of prostate cancer and metabolic diseases .

HY-119833

Rubone	Structural Classification Chalcones Flavonoids Leguminosae Source classification Plants Brachypterum robustum (Roxburgh ex Candolle) Dalzell & Gibson	MicroRNA
Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets .

HY-N0058R

4,5-Dicaffeoylquinic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Bowdichia virgilioides Plants Compositae Endogenous metabolite	HBV Endogenous Metabolite Apoptosis Glucosidase
4,5-Dicaffeoylquinic acid (Standard) is the analytical standard of 4,5-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

HY-113332

Myristoleic acid	Structural Classification Serenoa repens Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Animals Ketones, Aldehydes, Acids Palmae Inflammation/Immunology Disease Research Fields	Apoptosis Endogenous Metabolite
Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells .

HY-B0900

Anethole 1 Publications Verification Anise camphor; p-Propenylanisole; Isoestragole	Structural Classification Classification of Application Fields Source classification Plants Microorganisms Simple Phenylpropanols Leguminosae Phenylpropanoids Umbelliferae Vernonia Schreb. Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Apoptosis Fungal Bacterial MMP NF-κB
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-15194

Dimethylcurcumin 10+ Cited Publications ASC-J9; GO-Y025	Zingiber officinale Roscoe Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Plants Disease Research Fields Zingiberaceae Cancer	Androgen Receptor
Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer that effectively suppresses castration resistant prostate cancer cell proliferation and invasion.

HY-N0610A

Cinnamic acid 3-Phenylacrylic acid; β-Phenylacrylic acid	Structural Classification Microorganisms Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Cinnamic acid has potential use in cancer intervention, with IC₅₀s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.

HY-N3755

Dihydroresveratrol	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Dioscorea bulbifera Linn. Dioscoreaceae Cancer	Estrogen Receptor/ERR
Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations .

HY-N12782

Strospeside Gitoxigenin 3-O-monodigitaloside	Structural Classification Cuscuta reflexa Roxb. Source classification Plants Convolvulaceae Saccharides Monosaccharides	Others
Strospeside (Gitoxigenin 3-O-monodigitaloside) is a cardenolide and can be isolated from Cuscuta shoot. Strospeside has potent cytotoxicity against renal and prostate cancer cell lines .

HY-101017

Palmitoylcarnitine chloride 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite
Palmitoylcarnitine chloride is a fatty acid-derived mitochondrial substrate, and selectively decreases cell survival in colorectal and prostate cancer cells by affecting on pro-inflammatory pathways, Ca ²⁺ influx, and DHT-like effects .

HY-13626

Spisulosine ES-285	Alkaloids Classification of Application Fields Animals Source classification Marine natural products Other marine organisms Disease Research Fields Cancer	PKC
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation .

HY-109564

5α-Pregnane-3β,6α-diol-20-one	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Drug Metabolite
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

HY-N6969

Dicentrine	Alkaloids Structural Classification Classification of Application Fields Source classification Stephania epigaea Lo Plants Isoquinoline Alkaloids Menispermaceae Disease Research Fields Endocrinology	Adrenergic Receptor
Dicentrine is a natural product isolated from the plant Stephania epigaea Lo with antihypertensive effect. Dicentrine is an α₁-adrenoceptor antagonist which has effective against human hyperplastic prostates .

HY-B0661A

Tamsulosin hydrochloride (R)-(-)-YM12617; LY253351	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Endogenous Metabolite
Tamsulosin hydrochloride ((R)-(-)-YM12617) is an inhibitor of α₁-adrenergic receptor. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models .

HY-N12983

β-Bourbonene	Structural Classification other families Terpenoids Sesquiterpenes Source classification Dumortiera hirsuta (Sw.) Nees Plants	Apoptosis Bcl-2 Family
β-Bourbonene is a kind of sesquiterpene. β-Bourbonene inhibits cell growth, and induces apoptosis and G0/G1 arrest of prostate cancer PC-3M cells .

Cat. No.	Product Name	Chemical Structure

HY-70002S1

Enzalutamide-d6
Enzalutamide-d₆ is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells[1].

HY-70002S

Deutenzalutamide
Deutenzalutamide (Enzalutamide-d₃) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells .

HY-13702S

Nilutamide-d6
Nilutamide-d₆ (Nilandron-d6) is the deuterium labeled Nilutamide. Nilutamide (Nilandron) is a non-steroidal anti-androgen agent proposed in the research of metastatic prostatic carcinoma[1][2].

HY-N0610AS

Cinnamic acid-d6
Cinnamic acid-d₆ is the deuterium labeled Cinnamic acid. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.

HY-14249S1

Bicalutamide-d5
Bicalutamide-d₅ is deuterated labeled Bicalutamide (HY-14249). Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer .

HY-B0192S

Alfuzosin-d7
Alfuzosin-d₇ is the deuterium labeled Alfuzosin[1]. Alfuzosin (SL 77499-10) is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH)[2][3].

HY-B0192AS1

Alfuzosin-d7 hydrochloride
Alfuzosin-d₇ (hydrochloride) is the deuterium labeled Alfuzosin hydrochloride. Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).

HY-B0192AS

Alfuzosin-d3 hydrochloride
Alfuzosin-d3 hydrochloride is the deuterium labeled Alfuzosin hydrochloride. Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).

HY-14249S

Bicalutamide-d4
Bicalutamide-d₄ is the deuterium labeled Bicalutamide. Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer[1].

HY-13626S

Spisulosine-d3
Spisulosine-d₃ is deuterium labeled Spisulosine. Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKC

HY-B0661AS

Tamsulosin-d5 hydrochloride
Tamsulosin-d₅ (hydrochloride) is the deuterium labeled Tamsulosin hydrochloride. Tamsulosin hydrochloride ((R)-(-)-YM12617) is an inhibitor of α1-adrenergic receptor. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models[1].

HY-B0661AS1

Tamsulosin-d4 hydrochloride
Tamsulosin-d₄ (hydrochloride) is deuterium labeled Tamsulosin (hydrochloride). Tamsulosin hydrochloride ((R)-(-)-YM12617) is an inhibitor of α1-adrenergic receptor. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models[1].

HY-N0610AS2

Cinnamic acid-13C3
Cinnamic acid- ¹³C₃ (3-Phenylacrylic acid- ¹³C₃) is the ¹³C labeled Cinnamic acid (HY-N0610A). Cinnamic acid has potential use in cancer intervention, with IC₅₀s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells .

HY-B0371S

Terazosin-d8
Terazosin-d₈ is deuterium labeled Terazosin. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment[1][2][3].

HY-14281S

Trilostane-d3
Trilostane-d₃ is the deuterium-labeled Trilostane (HY-14281). Trilostane-d₃ (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. Trilostane-d₃ is a synthetic nonhormonal steroid. Trilostane-d₃ can be used for the research of breast cancer and prostate cancer .

HY-10528S

Tasquinimod-d3
Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn ²⁺ binding domain of HDAC4 with K_d of 10-30 nM. Tasquinimod also is a S100A9 inhibitor .

HY-111614S

Melengestrol acetate-d6

Melengestrol acetate-d₆ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-111614S1

Melengestrol acetate-d2

Melengestrol acetate-d₂ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-111614S2

Melengestrol acetate-d3

Melengestrol acetate-d₃ is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity[1]. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research[2].

HY-13635S

Finasteride-d9

Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

HY-B0391S1

Naftopidil-d5
Naftopidil-d₅ is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia[1][2].

HY-135794S

11-Ketodihydrotestosterone-d3

11-Ketodihydrotestosterone-d₃ is the deuterium labeled 11-Ketodihydrotestosterone. 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells[1][2].

HY-16474S

Relugolix-d6

Relugolix-d₆ is deuterium labeled Relugolix. Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209)[1]. Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al[2].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks