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Results for "

caspase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (355) 5-HT Receptor (1) ADC Cytotoxin (1) Adenosine Receptor (1) Adrenergic Receptor (2) AIM2 (2) Akt (19) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (4) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (11) Apoptosis (358) Arenavirus (2) Atg8/LC3 (1) Aurora Kinase (2) Autophagy (29) Bacterial (20) Bcl-2 Family (67) Beta-secretase (2) Biochemical Assay Reagents (6) BMI1 (1) Btk (1) c-Myc (2) Calcium Channel (9) CaMK (2) Cannabinoid Receptor (1) Carbonic Anhydrase (1) Casein Kinase (1) Cathepsin (4) CDK (15) Ceramidase (1) CFTR (2) Checkpoint Kinase (Chk) (1) Chloride Channel (3) Cholinesterase (ChE) (3) Claudin (1) COX (23) CRISPR/Cas9 (3) CRM1 (1) Cytochrome P450 (6) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (7) Drug Metabolite (4) DYRK (1) EGFR (5) Endogenous Metabolite (32) Enolase (1) Epigenetic Reader Domain (2) ERK (15) Eukaryotic Initiation Factor (eIF) (1) FAK (1) Fat Mass and Obesity-associated Protein (FTO) (1) Fatty Acid Synthase (FASN) (2) Ferroptosis (4) FKBP (1) Flavivirus (4) FLT3 (4) Fluorescent Dye (21) Formyl Peptide Receptor (FPR) (1) Free Fatty Acid Receptor (2) Fungal (4) FXR (1) GLUT (1) Glutaminase (3) Glutathione Peroxidase (1) GPR55 (2) GSK-3 (1) HDAC (13) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (2) Histone Demethylase (1) Histone Methyltransferase (1) HIV (3) HIV Protease (1) HSP (3) IAP (8) IFNAR (2) IGF-1R (2) iGluR (4) IKK (1) Influenza Virus (5) Integrin (6) Interleukin Related (26) Isotope-Labeled Compounds (16) JAK (3) JNK (10) Keap1-Nrf2 (2) Lactate Dehydrogenase (1) Lipoxygenase (3) MAP3K (1) MDM-2/p53 (16) MEK (1) mGluR (1) MicroRNA (1) Microtubule/Tubulin (8) Mitochondrial Metabolism (10) Mixed Lineage Kinase (1) MMP (5) Molecular Glues (3) mTOR (5) MyD88 (1) Myosin (2) Na+/Ca2+ Exchanger (2) Na+/K+ ATPase (1) nAChR (1) Necroptosis (5) Neurokinin Receptor (1) NF-κB (18) NO Synthase (1) NOD-like Receptor (NLR) (14) Nuclear Hormone Receptor 4A/NR4A (1) Orexin Receptor (OX Receptor) (2) P-glycoprotein (4) p38 MAPK (15) p62 (1) PAK (1) Paraptosis (1) Parasite (16) PARP (37) PDHK (1) PGE synthase (1) Phosphatase (4) Phospholipase (1) PI3K (9) Pim (1) PKC (5) Platelet-activating Factor Receptor (PAFR) (1) Polo-like Kinase (PLK) (1) Potassium Channel (8) PPAR (2) PROTACs (4) Protease Activated Receptor (PAR) (1) Proteasome (9) Pyroptosis (14) RABV (1) RAD51 (2) Raf (1) RAR/RXR (1) Ras (1) Reactive Oxygen Species (37) Ribosomal S6 Kinase (RSK) (1) RIP kinase (4) ROCK (1) ROR (1) ROS Kinase (2) Salt-inducible Kinase (SIK) (1) SARS-CoV (5) Ser/Thr Protease (2) Sigma Receptor (2) Sirtuin (2) Small Interfering RNA (siRNA) (2) SOD (1) Sodium Channel (1) STAT (8) TGF-β Receptor (1) TNF Receptor (9) Toll-like Receptor (TLR) (1) Topoisomerase (2) TRP Channel (4) Tyrosinase (3) VDAC (2) VEGFR (3) Virus Protease (2) Wnt (4) β-catenin (4) γ-secretase (2)
By Research Areas:	Cancer (439) Cardiovascular Disease (27) Endocrinology (8) Infection (65) Inflammation/Immunology (130) Metabolic Disease (29) Neurological Disease (75)
Oligonucleotides:	Nucleosides and their Analogs (1) siRNA drugs (2) siRNAs (2)

651

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

126

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Inhibitory Antibodies

143

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Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136975

Caspase-3-IN-1	Caspase	Neurological Disease Metabolic Disease
Caspase-3-IN-1 (compound 11b) is a potent *Caspase-3* inhibitor, with an IC₅₀ of 14.5 nM .

HY-P1095

Ivachtin caspase-3 Inhibitor VII	Caspase	Cardiovascular Disease Neurological Disease
Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl *caspase-3* inhibitor with an IC₅₀ of 23 nM. Ivachtin has modest selectivity for the remaining caspases .

HY-136744

Caspase-9 Inhibitor III Ac-LEHD-cmk	Caspase	Cardiovascular Disease
Caspase-9 Inhibitor III (Ac-LEHD-cmk) is a *caspase-9* inhibitor. Caspase-9 Inhibitor III exhibits protective effects on ischemia-reperfusion-induced myocardial injury .

HY-161991

Caspase-3 activator 4	Caspase Apoptosis	Cancer
Caspase-3 activator 4 (compound 4o) is a potent and cross the blood-brain barrier *caspase-3* activator. Caspase-3 activator 4 shows antiproliferative activity. Caspase-3 activator 4 induces apoptosis. Caspase-3 activator 4 increases the gene expression of TNF-α. Caspase-3 activator 4 decreases the protein expression of cleaved caspases 3/caspases 3 .

HY-W033813

Caspase-3/7 Inhibitor I	Caspase Apoptosis	Cancer
Caspase-3/7 inhibitor I is a potent and reversible inhibitor of *caspase-3* and *caspase-7, with K_is of 60 and 170 nM, respectively. Caspase-3/7 inhibitor I can inhibit apoptosis* in Camptothecin (HY-16560)-treated Jurkat cells and in chondrocytes .**

HY-W415273

Caspase-3-IN-2	Ser/Thr Protease HIV Protease Caspase	Infection
Caspase-3-IN-2 (Compound 4d) is the inhibitor for α-Chymotrypsin. Caspase-3-IN-2 also exhibits inhibitory activity against HIV protease and caspase 3 with an inhibition rate of 57% and 51% at 100 μM .

HY-P4222

IETD-CHO caspase-8-IN-1	Caspase	Others
IETD-CHO (Caspase-8-IN-1) is a potent *caspase-8* inhibitor .

HY-152756

Caspase-3/7 activator 2	Apoptosis Caspase	Cancer
Caspase-3/7 activator 2 is an effective activator of *Caspase-3/7. Caspase-3/7 activator 2 has tumor selectivity, anti-proliferative activity and high Apoptosis*-inducing ability .

HY-152748

Caspase-3/7 activator 1	Apoptosis Caspase	Cancer
Caspase-3/7 activator 1 is an effective activator of *Caspase-3/7. Caspase-3/7 activator 1 has tumor selectivity, anti-proliferative activity and high Apoptosis*-inducing ability .

HY-152758

Caspase-3/7 activator 3	Apoptosis Caspase	Cancer
Caspase-3/7 activator 3 is an effective activator of *Caspase-3/7. Caspase-3/7 activator 3 has tumor selectivity, anti-proliferative activity and high Apoptosis*-inducing ability .

HY-155389

Caspase-3 activator 2	Caspase	Cancer
Caspase-3 activator 2 (Compound 2f) is a caspase 3 activator that induces apoptosis and can be used in cancer research. Caspase-3 activator 2 is cytotoxic to HL-60 cells and K562 cells, with IC₅₀ values of 33.52 μM and 76.90 μM respectively .

HY-155390

Caspase-3 activator 3	Caspase Apoptosis	Cancer
Caspase-3 activator 3 (compound 2h) induces apoptosis in HL-60 and K562 cells via significant caspase 3 activation. Caspase-3 activator 3 shows antileukemic acticity against HL-60 and K562 cells, with IC₅₀ values of 42.89 and 33.61 μM, respectively .

HY-P0034

Ac-DEVD-CMK caspase-3 Inhibitor III	Caspase Apoptosis	Metabolic Disease
Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible *caspase-3* inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK can be used in a variety of experimental approaches to inhibit apoptosis .

HY-16990

Ac-YVAD-cmk 10+ Cited Publications caspase-1 Inhibitor II	Caspase	Inflammation/Immunology
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective *caspase-1* (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases .

HY-P0034A

Ac-DEVD-CMK TFA 2 Publications Verification caspase-3 Inhibitor III TFA	Caspase Apoptosis	Metabolic Disease
Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible *caspase-3* inhibitor. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; HY-137295). Ac-DEVD-CMK TFA can be used in a variety of experimental approaches to inhibit apoptosis .

HY-P10145

Ac-LEVD-pNA	Biochemical Assay Reagents Caspase	Others
Ac-LEVD-pNA is a chromogenic substrate for caspase-4 and can be used to detect caspase-4 activity .

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .

HY-P10276

Ac-VAD-AFC	Caspase	Cancer
Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases .

HY-136728

Ac-YVAD-AOM	Caspase	Cancer
Ac-YVAD-AOM is the inhibitor of *caspase*-1 that shows antitumor activity .

HY-P10104

Smac-N7, Penetratin conjugated	Caspase	Cancer
Smac-N7, Penetratin conjugated is a *caspase* activator derived from the second mitochondria-derived activator of caspases (SMAC) .

HY-P10240

Ac-WVAD-AMC	Fluorescent Dye	Others
Ac-WVAD-AMC is a fluorogenic substrate for caspase 1 .

HY-P2012

TRP-601	Caspase Bcl-2 Family	Others
TRP-601 is a *caspase* inhibitor. TRP-601 reversed the increased expression of active *caspase-2*, the activation of endogenous apoptotic pathway and the up-regulation of key protein triggered by hyperoxia .

HY-P1009

Z-YVAD-FMK 15+ Cited Publications	Caspase	Cancer
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .

HY-108312A

AC-VEID-CHO TFA	Caspase	Neurological Disease
AC-VEID-CHO (TFA) is a peptide-derived *caspase* inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC₅₀ values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO (TFA) can be used for the research of neurodegenerative conditions including Alzheimer’s and Huntington’s disease .

HY-P2615

Ac-VDVAD-AFC	Fluorescent Dye	Cancer
Ac-VDVAD-AFC is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-P2615A

Ac-VDVAD-AFC TFA	Fluorescent Dye	Cancer
Ac-VDVAD-AFC TFA is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC TFA can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-155613

M867	Caspase	Cancer
M867 is a selective and reversible inhibitor of *caspase-3* with an IC₅₀ of 1.4 nM and K_i of 0.7 nM. M867 has anti apoptotic activity .

HY-P10450

(Asp)2-Rhodamine 110 D2R; (D)2-Rhodamine 110	Caspase	Others
(Asp)2-Rhodamine 110 (D2R) is a fluorescent caspase substrate .

HY-P10083

Ac-VQVD-pNA	Fluorescent Dye	Others
Ac-VQVD-pNA is a chromogenic substrate of *caspase* 3 .

HY-P10236

Ac-WEHD-pNA	Caspase	Others
Ac-WEHD-pNA is a colorimetric substrate for *caspase* 1, 4, 5 and 14, which is utilized to measure the caspase activity .

HY-P10103

Smac-N7 peptide	Caspase	Cancer
Smac-N7 peptide, the seven N-terminal amino acid of the mitochondrial protein Smac (second mitochondria-derived activator of caspase), cannot pass through the cell membrane .

HY-14570

Triphen diol	Apoptosis	Cancer
Triphen diol is a phenol diol derivative, which has excellent anticancer activity against pancreatic cancer and cholangiocarcinoma, and can induce pancreatic cell apoptosis through two mechanisms, caspase-mediated and caspase-independent .

HY-P2617

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a *fluorogenic caspase-1 substrate. Ac-WEHD-AFC can measure caspase*-1 fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P2617A

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a *fluorogenic caspase-1 substrate. Ac-WEHD-AFC TFA can measure caspase*-1 fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P5834

Boc-AEVD-CHO	Caspase Apoptosis	Inflammation/Immunology
Boc-AEVD-CHO is a Caspase 8 inhibitor useful in the study of apoptosis and immune and inflammatory diseases .

HY-130476

Satratoxin G	Caspase Apoptosis	Cancer
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of *caspase* .

HY-N8617

Trijuganone C	Caspase	Cancer
Trijuganone C, a natural product extracted from Salvia miltiorrhiza, inhibits the proliferation of cancer cells through induction of apoptosis mediated by mitochondrial dysfunction and caspase activation .

HY-P4403

Z-DEVD-R110 (Z-Asp-Glu-Val-Asp)₂-Rhodamine 110	Fluorescent Dye Apoptosis Caspase	Others
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)₂-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .

HY-10396A

(2R,3S)-Emricasan (2R,3S)-PF 03491390; (2R,3S)-IDN-6556	Caspase Flavivirus	Infection Neurological Disease Cancer
(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan (HY-10396). Emricasan is an orally active and irreversible *pan-caspase* inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in *caspase-3* activity and protected human cortical neural progenitors .

HY-10397A

MX1013 2 Publications Verification CV1013; Z-VD-FMK	Caspase	Cancer
MX1013 is a potent, irreversible dipeptide *caspase* inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC₅₀ of 30 nM .

HY-125018

QM31 SVT016426	Caspase	Cancer
QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC₅₀=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint .

HY-P10146

Ac-LETD-CHO	Caspase	Cancer
Ac-LETD-CHO is a caspases 8 inhibitor. Ac-LETD-CHO has specific inhibition to casp-8 with an IC₅₀ value of 6.71 nM. Ac-LETD-CHO can be used for the research of anticancer .

HY-N8498

GKK1032B	Apoptosis	Cancer
GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation .

HY-106591A

4-Vinylcyclohexene dioxide Vinylcyclohexene diepoxide	Apoptosis	Cardiovascular Disease
4-Vinylcyclohexene dioxide is a metabolite of 4-vinylcyclohexene that can specifically destroy oocytes in primordial and primary follicles of rats and mice. 4-Vinylcyclohexene dioxide induces apoptosis in rat cells is associated with activation of a caspase-mediated cascade .

HY-113963

Ac-IETD-CHO	Apoptosis	Cancer
Ac- IETD- CHO is a potent, reversible inhibitor of granzyme B and *caspase-8*. Ac- IETD- CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac- IETD- CHO also inhibits cytotoxic T lymphocytes induced cell death .

HY-N0530

Dryocrassin ABBA 2 Publications Verification Dryocrassin	Apoptosis Influenza Virus	Cancer
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by *Caspase* .

HY-120838

Heptelidic acid 1 Publications Verification Koningic acid	Caspase	Infection Cancer
Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic . Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of *caspases* . Koningic acid (KA) is a specific GAPDH inhibitor with an IC₅₀of 90 μM .

HY-146253

CDK1/2/4-IN-1	CDK Apoptosis Bcl-2 Family Caspase	Cancer
CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC₅₀ values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research .

HY-169259

HDAC9-IN-1	HDAC	Cancer
HDAC9-IN-1 (Compound 7g) is a potent HDAC9 inhibitor, with an IC₅₀ of 40 nM. HDAC9-IN-1 significantly inhibits several human cancer cells, induces apoptosis, modulates caspase-related proteins as well as p38, and causes DNA damage .

HY-168443

HTR2A antagonist 1	5-HT Receptor Apoptosis	Cancer
HTR2A antagonist 1 (Compound 15f) is a HTR2A antagonist, with an IC₅₀ of 42.79 nM. HTR2A antagonist 1 induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells via the activation of p53/p21/caspase 3 signaling. HTR2A antagonist 1 has good liver microsomal stability. HTR2A antagonist 1 can be used for the research of colorectal cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0530

Dryocrassin ABBA 2 Publications Verification Dryocrassin	Infection Structural Classification Classification of Application Fields Dryopteridaceae Source classification Phenols Polyphenols Dryopteris crassirhizoma Nakai Plants Disease Research Fields	Apoptosis Influenza Virus
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by *Caspase* .

HY-N6818

5,7,4'-Trimethoxyflavone MTF	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Kaempferia parviflora Wall. ex Baker Plants Disease Research Fields Zingiberaceae Cancer	Apoptosis Caspase PARP Endogenous Metabolite CFTR
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of *caspase-3, and degradation of ADP-ribose polymerase (PARP)* protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-113505

Delta-12-Prostaglandin J2 Δ12-PGJ2	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation .

HY-N0605

Ginsenoside Rh2 4 Publications Verification 20(S)-Ginsenoside Rh2; 20(S)-Rh2; Ginsenoside-Rh2	Panax ginseng C. A. Meyer Triterpenes Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	Caspase Apoptosis Endogenous Metabolite
Ginsenoside Rh2 induces the activation of *caspase-8* and *caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis* in a multi-path manner.

HY-130476

Satratoxin G	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Caspase Apoptosis
Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of *caspase* .

HY-N8617

Trijuganone C	Quinones Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Benzene Quinones Plants Naphthalene Quinones	Caspase
Trijuganone C, a natural product extracted from Salvia miltiorrhiza, inhibits the proliferation of cancer cells through induction of apoptosis mediated by mitochondrial dysfunction and caspase activation .

HY-N8498

GKK1032B	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Apoptosis
GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation .

HY-N6818R

5,7,4'-Trimethoxyflavone (Standard) MTF (Standard)	Structural Classification Flavonoids Flavones Source classification Kaempferia parviflora Wall. ex Baker Plants Zingiberaceae	Apoptosis Caspase PARP Endogenous Metabolite CFTR
5,?7,?4'-Trimethoxyflavone (Standard) is the analytical standard of 5,?7,?4'-Trimethoxyflavone. This product is intended for research and analytical applications. 5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-P2569

Malformin A1	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis
Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9 .

HY-N2741

Vitexin B-1	Structural Classification Monophenols Verbenaceae Source classification Phenols Plants Vitex negundo Linn.	Bcl-2 Family
Vitexin B-1 is an inhibitor of Bcl-2 and the agonist of *Caspase. Vitexin B-1 has cytotoxic effect and induces apoptosis* in MCF-7, ZR-75-1, MDA-MB-231, and COC1 cells with IC₅₀s of 3.2, 2.1, 1.8 and 0.39 μM, respectively .

HY-N2342

Procyanidin C1 4 Publications Verification PCC1	Structural Classification Classification of Application Fields Source classification Rosaceae Crataegus pinnatifida Bge. Plants Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Disease Research Fields Cancer	Apoptosis
Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice .

HY-19696

Tauroursodeoxycholate 70+ Cited Publications Tauroursodeoxycholic acid; TUDCA; UR 906	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Endogenous Metabolite Apoptosis
Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as *caspase-3* and *caspase-12. Tauroursodeoxycholate also inhibits ERK*.

HY-19696A

Tauroursodeoxycholate sodium 70+ Cited Publications Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Apoptosis Endogenous Metabolite
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as *caspase-3* and *caspase-12. Tauroursodeoxycholate also inhibits ERK*.

HY-19696B

Tauroursodeoxycholate dihydrate 70+ Cited Publications Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	ERK Caspase Apoptosis Endogenous Metabolite
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as *caspase-3* and *caspase-12. Tauroursodeoxycholate also inhibits ERK* .

HY-N3376

Liriodenine Spermatheridine; VLT045	Alkaloids Structural Classification Classification of Application Fields Magnoliaceae Source classification Pyridine Alkaloids Liriodendron chinense (Hemsl.) Sarg. Plants Disease Research Fields Cancer	Apoptosis
Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant?Mitrephora sirikitiae?and has anti-cancer activities . Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9 .

HY-19696R

Tauroursodeoxycholate (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	ERK Caspase Endogenous Metabolite Apoptosis
Tauroursodeoxycholate (Standard) is the analytical standard of Tauroursodeoxycholate. This product is intended for research and analytical applications. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-N6861

Lucidenic acid B	Triterpenes Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Endogenous metabolite Disease Research Fields Cancer	Apoptosis
Lucidenic acid B is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells .

HY-N2342R

Procyanidin C1 (Standard)	Structural Classification Flavonoids Source classification Rosaceae Phenols Polyphenols Crataegus pinnatifida Bge. Plants Biflavones	Apoptosis
Procyanidin C1 (Standard) is the analytical standard of Procyanidin C1. This product is intended for research and analytical applications. Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice .

HY-N0605R

Ginsenoside Rh2 (Standard) 20(S)-Ginsenoside Rh2(Standard); 20(S)-Rh2(Standard); Ginsenoside-Rh2 (Standard)	Panax ginseng C. A. Meyer Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields Araliaceae Cancer	Caspase Apoptosis Endogenous Metabolite
Ginsenoside Rh2 (Standard) is the analytical standard of Ginsenoside Rh2. This product is intended for research and analytical applications. Ginsenoside Rh2 induces the activation of *caspase-8* and *caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis* in a multi-path manner.

HY-N1157

Thevetiaflavone Apigenin-5-methyl ether	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Bcl-2 Family Caspase
Thevetiaflavone could upregulate the expression of Bcl-2 and downregulate that of Bax and *caspase-3*.

HY-N0905

Ginsenoside Rh4	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Bcl-2 Family Caspase Apoptosis Autophagy Endogenous Metabolite
Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, caspase 8, and caspase 9. Ginsenoside Rh4 also induces autophagy.

HY-N13123

Tenacissoside C	Triterpenes Structural Classification Terpenoids Marsdenia tenacissima (Roxb.) Moon Source classification Asclepiadaceae Plants	Apoptosis
Tenacissoside C is an anti-cancer compound that inhibits angiogenesis. Tenacissoside C induces apoptosis in cancer cells by down-regulating the expression of anti-apoptotic factors and activating caspase-9 and caspase-3. Tenacissoside C also causes cell cycle arrest in cancer cells and induces apoptosis through the mitochondrial pathway.

HY-N6681

15-Acetoxyscirpenol	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Caspase Bacterial Apoptosis Antibiotic
15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other *caspases* independent of caspase-3 .

HY-124896

Bonannione A 6-Geranylnaringenin; Mimulone	Paulownia tomentosa (Thunb.) Steud. Scrophulariaceae Plants	Phosphatase Apoptosis Autophagy
Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity .

HY-N11648

Ganoderic acid T1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Apoptosis Caspase
Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity .

HY-W046353

2-Methoxycinnamaldehyde o-Methoxycinnamaldehyde	Structural Classification Cinnamomum cassia (L.) D. Don Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Plants Lauraceae Disease Research Fields Cancer	Apoptosis
2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity . 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9 . 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration .

HY-N2632

Uvarigrin	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Apoptosis
Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation .

HY-N0702

Tenuifolin	Triterpenes Structural Classification Terpenoids Source classification Polygalaceae Plants Polygala tenuifolia Willd.	Beta-secretase Cholinesterase (ChE)
Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD).

HY-N1970

5,7-Dihydroxychromone 1 Publications Verification	Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants Isoflavones	Keap1-Nrf2 Arenavirus Caspase PARP
5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated *caspase-3* and *caspase-9* and cleaved PARP in 6-OHDA-induced SH-SY5Y cells .

HY-N0674A

Dehydrocorydaline chloride 30+ Cited Publications 13-Methylpalmatine chloride	Infection Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates *caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain .

HY-N0674B

Dehydrocorydaline (hydroxyl) 30+ Cited Publications 13-Methylpalmatine (hydroxyl)	Structural Classification Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N0674

Dehydrocorydaline 30+ Cited Publications 13-Methylpalmatine	Infection Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates *caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N4238

Dehydrocorydaline nitrate 30+ Cited Publications 13-Methylpalmatine nitrate	Infection Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates *caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. . Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-W046353R

2-Methoxycinnamaldehyde (Standard)	Structural Classification Cinnamomum cassia (L.) D. Don Simple Phenylpropanols Source classification Phenylpropanoids Plants Lauraceae	Apoptosis
2-Methoxycinnamaldehyde (Standard) is the analytical standard of 2-Methoxycinnamaldehyde. This product is intended for research and analytical applications. 2-Methoxycinnamaldehyde (o-Methoxycinnamaldehyde) is a natural compound of Cinnamomum cassia, with antitumor activity . 2-Methoxycinnamaldehyde inhibits proliferation and induces apoptosis by mitochondrial membrane potential (ΔΨm) loss, activation of both caspase-3 and caspase-9 . 2-Methoxycinnamaldehyde effectively inhibits platelet-derived growth factor (PDGF)-induced HASMC migration .

HY-N0702R

Tenuifolin (Standard)	Triterpenes Structural Classification Terpenoids Source classification Polygalaceae Plants Polygala tenuifolia Willd.	Beta-secretase Cholinesterase (ChE)
Tenuifolin (Standard) is the analytical standard of Tenuifolin. This product is intended for research and analytical applications. Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD) .

HY-N2490

Dehydrotrametenolic acid	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Source classification Poria cocos Plants Inflammation/Immunology Disease Research Fields	Caspase Apoptosis
Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid induces apoptosis through *caspase-3* pathway. Dehydrotrametenolic acid has anti-tumor activity, anti-inflammatory, anti-diabetic effects .

HY-N7569

Demethoxyfumitremorgin C	Structural Classification Alkaloids Microorganisms Source classification Marine natural products Other marine organisms Indole Alkaloids	Apoptosis Caspase PPAR
Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates *caspase*-3, -8, and -9, leading to PARP/ cleavage .

HY-N1970R

5,7-Dihydroxychromone (Standard)	Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants Isoflavones	Keap1-Nrf2 Arenavirus Caspase PARP
5,7-Dihydroxychromone (Standard) is the analytical standard of 5,7-Dihydroxychromone. This product is intended for research and analytical applications. 5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells .

HY-W012499

N-Acetyl-L-methionine 1 Publications Verification N-Acetylmethionine	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Caspase Mitochondrial Metabolism
N-Acetyl-L-methionine is a dietary supplementation. N-Acetyl-L-methionine increases *caspase-3* activity and inhibits mitochondrial activity. N-Acetyl-L-methionine promotes lactation and improves meat quality .

HY-N8464

Juncuenin D	Structural Classification Natural Products Juncaceae Source classification Plants Juncus acutus L.	Bacterial
Juncuenin D induces *caspase-3*-mediated cytotoxicity in HT22 cells. Juncuenin D also has anti-bacterial activity against MRSA strains. Juncuenin D can be isolated from J. effusus .

HY-N0551

Wedelolactone 15+ Cited Publications	Structural Classification Classification of Application Fields Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	Caspase Lipoxygenase Apoptosis
Wedelolactone suppresses LPS-induced *caspase-11* expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-N6690

Destruxin B	Infection Structural Classification Microorganisms Classification of Application Fields Cyclopeptides Source classification Disease Research Fields	Bcl-2 Family Caspase Apoptosis
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells . Destruxin B significantly activates *caspase-3* and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo .

HY-N12503

Patuletin	Structural Classification Flavonols Flavonoids Source classification Amaranthaceae Plants Spinacia oleracea L.	Apoptosis Caspase
Patuletin is a flavonol, that can be isolated from the flowers of Tagetes patula. Patuletin shows anti-proliferative activity against cancer cells. Patuletin causes significant nuclear fragmentation and has a great capacity to induce *caspase-3* activation .

HY-N2802

Euptox A 9-Oxo-10,11-dehydroageraphorone	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Derris indica	Apoptosis Caspase Parasite
Euptox A (9-Oxo-10, 11-dehydroageraphorone), a cadenine sesquiterpene, is the main toxin that can be isolated from Eupatorium adenophorum. Euptox A induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells .

HY-W106456

3-Methoxy-9H-Carbazole	Structural Classification Alkaloids Pyrrole Alkaloids Clausena heptaphylla (Roxb.) Wight & Arn. Source classification Rutaceae Plants	Caspase Reactive Oxygen Species Apoptosis
3-Methoxy-9H-Carbazole induces *caspase-3* activities and the cellular generation of eactive oxygen species. 3-Methoxy-9H-Carbazole inhibits cancer cell proliferation and induces apoptosis .

HY-N0763

Angelicin 5+ Cited Publications Isopsoralen	Structural Classification Classification of Application Fields Leguminosae Source classification Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating *caspase-9* and *caspase-3*.

HY-N3584

Paris saponin VII 3 Publications Verification Chonglou Saponin VII	Structural Classification Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of *Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt*. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-N13891

Arisostatin A	Structural Classification Natural Products Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Apoptosis
Arisostatin A, a microbial secondary metabolite, is an antibiotic against Gram-positive bacteria and shown to possess potent anti-tumor properties. Arisostatin A induces apoptosis through the activation of caspase-3 and reactive oxygen species (ROS) generation in AMC-HN-4 cells .

HY-N2602

Sanggenol L	Structural Classification Flavonoids Classification of Application Fields Morus mongolica (Bur.) Schneid. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	MDM-2/p53
Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells . Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p

HY-W041489

Chelidonic acid 1 Publications Verification	Classification of Application Fields Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Papaveraceae Cancer	NF-κB Caspase
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and *caspase-1* . Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

Cat. No.	Product Name	Chemical Structure

HY-19696S

Tauroursodeoxycholate-d5
Tauroursodeoxycholate-d₅ is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696AS

Tauroursodeoxycholate-d4 sodium
Tauroursodeoxycholate-d₄ (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S1

Tauroursodeoxycholate-d4
Tauroursodeoxycholate-d₄ is deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-19696S2

Tauroursodeoxycholate-d4-1
Tauroursodeoxycholate-d₄-1 is the deuterium labeled Tauroursodeoxycholate. Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

HY-W015879S

2-Heptanol-d5
2-Heptanol-d₅ is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation .

HY-B1138S

Fenbufen-d9

Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

HY-W020050S

Cystamine-d8 dihydrochloride

Cystamine-d₈ (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride）[1]. Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)[2][3][4].

HY-B1899S

Taurodeoxycholic acid-d5

Taurodeoxycholic acid-d₅ is the deuterium labeled Taurodeoxycholic acid (HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .

HY-B0347S3

Lacidipine-13C4

Lacidipine- ¹³C₄ is ¹³C labeled Lacidipine (HY-B0347). Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

HY-B0347S1

Lacidipine-13C8

Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃ is the deuterium labeled Dihydrocapsaicin (HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-109583S

4-Oxofenretinide-d4
4-Oxofenretinide-d₄ (4-Oxo-4-HPR-d₄) is deuterium labeled 4-Oxofenretinide. 4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9 .

HY-N6801S

Nivalenol-13C15

Nivalenol- ¹³C₁₅ is the ¹³C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .

HY-15037S2

Diclofenac-13C6 sodium

Diclofenac- ¹³C₆ (Sodium) is the ¹³C₆ labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15036S1

Diclofenac-13C6
Diclofenac- ¹³C₆ is the ¹³C₆ labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15037S1

Diclofenac-d4 sodium

Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-15036S

Diclofenac-d4
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-B0148S

Risedronic acid-d4

Risedronic acid-d₄ (Risedronate-d₄) is the deuterium labeled Risedronic acid (HY-B0148).Risedronic acid (Risedronate) sodium, a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid sodium suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid sodium inhibits blood stages of Plasmodium falciparum (IC₅₀ of 20.3 μM). Risedronic acid sodium inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins .

HY-15037S

Diclofenac-13C6 sodium heminonahydrate

Diclofenac- ¹³C₆ (sodium heminonahydrate) is the ¹³C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

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