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Carcinoma

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (3) 5-HT Receptor (1) ADC Antibody (1) ADC Cytotoxin (6) Akt (21) Aldose Reductase (1) Aminopeptidase (1) AMPK (1) Anaplastic lymphoma kinase (ALK) (5) Androgen Receptor (1) Antibiotic (17) Antibody-Drug Conjugates (ADCs) (3) Antifolate (1) Apoptosis (194) Arp2/3 Complex (1) Atg8/LC3 (1) ATM/ATR (2) Aurora Kinase (1) Autophagy (57) Bacterial (24) Bcl-2 Family (10) BCL6 (2) Beclin1 (1) Biochemical Assay Reagents (4) Btk (1) c-Met/HGFR (13) Calcium Channel (1) CaMK (1) Carbonic Anhydrase (2) Casein Kinase (2) Caspase (14) Cathepsin (1) CDK (15) Checkpoint Kinase (Chk) (1) Cholecystokinin Receptor (1) Cholinesterase (ChE) (1) ClpP (1) CMV (2) COX (8) CRM1 (1) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (6) Deubiquitinase (2) DNA Alkylator/Crosslinker (6) DNA-PK (2) DNA/RNA Synthesis (13) Drug Metabolite (4) DYRK (2) E1/E2/E3 Enzyme (3) EBV (2) EGFR (17) Endogenous Metabolite (46) Ephrin Receptor (1) Epigenetic Reader Domain (6) ERK (19) Estrogen Receptor/ERR (5) FAK (2) Ferroptosis (9) FGFR (14) Filovirus (1) Flavivirus (1) Fluorescent Dye (3) Fungal (3) Furin (2) FXR (2) Gli (1) Glucosidase (2) GLUT (2) Glutaminase (2) Glutathione S-transferase (1) GSK-3 (1) HBV (2) HCV (4) HDAC (8) Hedgehog (6) HIF/HIF Prolyl-Hydroxylase (7) Histamine Receptor (1) Histone Acetyltransferase (5) Histone Demethylase (1) Histone Methyltransferase (2) HIV (4) HPV (2) HSP (6) HSV (7) IAP (3) IFNAR (1) IGF-1R (1) iGluR (2) Influenza Virus (4) Integrin (4) Interleukin Related (5) Isotope-Labeled Compounds (11) JAK (4) JNK (4) Keap1-Nrf2 (2) LAG-3 (1) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (1) Liposome (2) LPL Receptor (1) LXR (1) mAChR (1) Macrophage migration inhibitory factor (MIF) (1) MAPKAPK2 (MK2) (1) MDM-2/p53 (9) MEK (13) MicroRNA (3) Microtubule/Tubulin (10) Mitochondrial Metabolism (2) MMP (5) Molecular Glues (1) Monoamine Oxidase (4) Mps1 (1) mTOR (8) Mucin (1) Na+/H+ Exchanger (NHE) (2) Na+/K+ ATPase (2) nAChR (2) NAMPT (3) Necroptosis (1) Nectin-4 (5) NF-κB (20) Notch (1) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (1) P-glycoprotein (5) P2X Receptor (2) p38 MAPK (15) PAI-1 (2) Paraptosis (1) Parasite (8) PARP (5) PD-1/PD-L1 (10) PDHK (1) PERK (2) Phosphatase (5) Phosphodiesterase (PDE) (1) Phospholipase (1) PI3K (13) PKA (2) PKC (5) Polo-like Kinase (PLK) (3) Potassium Channel (2) PPAR (6) Prostaglandin Receptor (2) PROTACs (5) Protease Activated Receptor (PAR) (2) Proteasome (1) Pyroptosis (1) Raf (5) RAR/RXR (6) Ras (7) Reactive Oxygen Species (22) Renin (5) RET (3) Reverse Transcriptase (2) ROCK (1) ROR (1) ROS Kinase (3) RSV (1) SARS-CoV (6) Ser/Thr Protease (1) SF3B1 (1) SHP2 (4) Sirtuin (4) Smo (4) Sodium Channel (10) SphK (2) Src (2) STAT (12) Survivin (3) Syk (3) TAM Receptor (2) TGF-beta/Smad (2) TGF-β Receptor (2) TNF Receptor (2) Toll-like Receptor (TLR) (12) Topoisomerase (12) Trk Receptor (3) TRP Channel (9) TrxR (1) Tyrosinase (5) ULK (1) VEGFR (9) Wee1 (1) Wnt (3) Xanthine Oxidase (1) YAP (1) β-catenin (1)
By Research Areas:	Cancer (600) Cardiovascular Disease (33) Endocrinology (2) Infection (60) Inflammation/Immunology (80) Metabolic Disease (29) Neurological Disease (22)
Oligonucleotides:	Pegylated Lipids (1) Aptamers (1) Phospholipids (1) Polymers (1) Antisense Oligonucleotides (1) siRNAs (2)

622

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

183

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7651

Neoanhydropodophyllol	Others	Cancer
Neoanhydropodophyllol is a cyclolignan derivative, with antineoplastic activity. Neoanhydropodophyllol displays cytotoxicity against several cancer cells (leukemia, lung carcinoma and colon carcinoma) .

HY-P99758

Nofazinlimab CS1003	PD-1/PD-L1	Cancer
Nofazinlimab (CS1003) is a humanised IgG4 anti-PD-1 monoclonal antibody. Nofazinlimab can be used for unresectable hepatocellular carcinoma (uHCC) research .

HY-105164

Topixantrone BBR 3576	Others	Cancer
Topixantrone (BBR 3576) is an antitumor agent, and shows antitumor activity on prostate carcinoma .

HY-105164A

Topixantrone dihydrochloride BBR 3576 dihydrochloride	Others	Cancer
Topixantrone (BBR 3576) dihydrochloride is an antitumor agent, and shows antitumor activity on prostate carcinoma .

HY-137931

Testololactone	Others	Cancer
Testololactone is an aromatase inhibitor. Testololactone can be used for research of breast carcinoma .

HY-W725179

VK-2019	EBV	Cancer
VK-2019 is an oral active, selective EBNA1((Epstein-Barr Nuclear Antigen 1) inhibitor and can be used for study of EBV-associated carcinomas .

HY-130352

9-SAHSA	Endogenous Metabolite	Cancer
9-SAHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs). 9-SAHSA is a protective molecule to prevent colon carcinoma cells from apoptotic cell death .

HY-161610

FGFR4-IN-21	FGFR	Cancer
FGFR4-IN-21 (Compd 4c) is a FGFR4 inhibitor with an IC₅₀ of 33 nM. FGFR4-IN-21 can be used for hepatocellular carcinoma research .

HY-N10204

Rostratin B	Endogenous Metabolite	Cancer
Rostratin B, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC₅₀ of 1.9 μg/mL .

HY-157030

NIEA	Others	Cancer
NIEA is a potent carcinogen that induce pancreatic cancer, esophageal cancer and hepatocellular carcinoma .

HY-121160

Amiprilose SM1213; Therafectin	Bacterial	Infection Cancer
Amiprilose (SM1213; Therafectin) is a potent inhibitor against Hepatocellular carcinoma (HCC). Amiprilose induces lymphokine-induced macrophage activation directly to kill Listeria monocytogenes .

HY-16459

Glycididazole sodium Sodium glycididazole	Apoptosis	Cancer
Glycididazole sodium (Sodium glycididazole) is a radiosensitizer. Glycididazole sodium increases the sensitivity of nasopharyngeal carcinoma cells to radiation, through increaased DNA damage and enhanced apoptosis in NPC cells

HY-103257

CHM-1 NSC656158	Microtubule/Tubulin	Cancer
CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G₂-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity .

HY-119425

Razoxane ICRF 159	Topoisomerase	Cancer
Razoxane (ICRF 159) is an antiangiogenic topoisomerase II inhibitor, can be used for the research of renal cell carcinoma (RCC) .

HY-119320

Ethimidine Aethimidinum	Others	Cancer
Ethimidine (Aethimidinum) can reduce the blood serum free SH (sulfhydryl) in in rats previously transplanted with sarcoma or carcinoma cells .

HY-P99384

Vofatamab B-701; MFGR-1877S; RG-7444	FGFR	Cancer
Vofatamab (B-701) is an anti-FGFR3 monoclonal antibody (mAb). Vofatamab blocks activation of both the wildtype and genetically activated receptor. Vofatamab can be used in the research of metastatic urothelial carcinoma (mUC) .

HY-147426

Zifcasiran ADS-007; ARO HIF2	HIF/HIF Prolyl-Hydroxylase	Cancer
Zifcasiran is a hypoxia-inducible factor (HIF) synthesis reducer. Zifcasiran shows antitumor activities and can be used in advanced renal cell carcinoma research .

HY-147426A

Zifcasiran sodium ADS-007 sodium; ARO HIF2 sodium	HIF/HIF Prolyl-Hydroxylase	Cancer
Zifcasiran sodium is a hypoxia-inducible factor (HIF) synthesis reducer. Zifcasiran sodium shows antitumor activities and can be used in advanced renal cell carcinoma research .

HY-D2312

Mito-Rh-S	Fluorescent Dye Ferroptosis	Cancer
Mito-Rh-S is a ratiometric near-infrared (NIR) fluorescent probe that detects the fluctuation of mitochondrial HClO levels during ferroptosis in hepatocellular carcinoma (HCC) .

HY-N4168B

Methyl chlorogenate	Others	Cancer
Methyl chlorogenate is an antioxidant, and has radical scavenging activity. Methyl chlorogenate is an anti-inflammatory agent. Methyl chlorogenate also inhibits hepatocellular carcinoma (HCC) cell proliferation and metastasis .

HY-151461

CHNQD-01255	Others	Cancer
CHNQD-01255 is an orally active Arf-GEFs inhibitor with potent anti-hepatocellular carcinoma (HCC) efficacy .

HY-N10205

Rostratin C	Endogenous Metabolite	Cancer
Rostratin C, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC₅₀ value of 0.76μg /mL .

HY-19412

DMS-612 NSC-281612	Others	Cancer
DMS-612 (NSC-281612) is an alkylating agent with anti-renal cell carcinoma activity. DMS-612 can be used in cancer research .

HY-N11429

Glycochenodeoxycholic acid 3-glucuronide	Endogenous Metabolite	Metabolic Disease Cancer
Glycochenodeoxycholic acid 3-glucuronide is a type of steroid glucuronide and a plasma metabolite that can be used in the research of biomarkers for diabetes and hepatocellular carcinoma (HCC) .

HY-N2591A

Isocorydine hydrochloride	Endogenous Metabolite	Cancer
Isocorydine hydrochloride is isolated from Dicranostigma leptopodum (Maxim.) Fedde (DLF). Isocorydine hydrochloride combines with Doxorubicin (DOX) has a promising potential to eradicate hepatocellular carcinoma (HCC) .

HY-161854

LASSBio-1911	HDAC	Cancer
LASSBio-1911 is a potent inhibitor of HDAC6. LASSBio-1911 shows antitumor in hepatocellular carcinoma (HCC) cells with minimal on normal cells .

HY-N6623

Malvidin-3-galactoside chloride	Apoptosis Endogenous Metabolite Reactive Oxygen Species	Cancer
Malvidin-3-galactoside chloride, an anthocyanin monomer, induces hepatocellular carcinoma (HCC) cells cycle arrest and apoptosis. Malvidin-3-galactoside chloride inhibits the production and accumulation of ROS. Malvidin-3-galactoside chloride has anti-tumor function .

HY-161679S

Pyruvate Carboxylase-IN-3	Isotope-Labeled Compounds	Cancer
Pyruvate Carboxylase-IN-3 (Compd 36) is a potent Pyruvate Carboxylase inhibitor. Pyruvate Carboxylase-IN-3 inhibits hepatocellular carcinoma cells activity with an IC₅₀ of 4.3 μM .

HY-N10158

1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one	Others	Cancer
1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one (compound 39), a diarylheptanoid, exhibits antiproliferative activity towards human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells .

HY-N1622

1-Dehydroxy-23-deoxojessic acid	Others	Cancer
1-Dehydroxy-23-deoxojessic acid (compound 10) is a cycloartane-type triterpene. 1-Dehydroxy-23-deoxojessic acid exhibits cytotoxicity against murine colon 26-L5 carcinoma cells, with an EC₅₀ of 62.38 μM .

HY-D1542

Mucicarmine	Fluorescent Dye	Cancer
Mucicarmine is used in the histological visualization of acid mucopolysaccharides in tissue sections. Mucicarmine can identify mucin (deep rose), which is useful in determining the mucin positive cancer (such as liver carcinoma) .

HY-N7507A

Sempervirine nitrate	Wnt β-catenin	Cancer
Sempervirine is an alkaloid derived from Gelsemium elegans Benth.. Sempervirine inhibits the proliferation of hepatocellular carcinoma (HCC) cells and induces apoptosis by regulating Wnt/β-catenin pathway .

HY-P10524A

N188 TFA	Nectin-4	Cancer
N188 TFA is a radioligand based on a bicyclic peptide backbone that targets nectin-4, a protein overexpressed in many tumors. N188 TFA can be efficiently radiolabeled to 68Ga-N188, a radioisotope suitable for positron emission tomography (PET) imaging. The development of N188 TFA and its radiolabeled form 68Ga-N188 can be used for the diagnosis and treatment of tumors such as urothelial carcinoma .

HY-133100

5-ALA benzyl ester hydrochloride Benzyl-ALA hydrochloride	Endogenous Metabolite	Cancer
5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines .

HY-101840A

EIPA hydrochloride 45+ Cited Publications L593754 hydrochloride; MH 12-43 hydrochloride; Ethylisopropylamiloride hydrochloride	TRP Channel Autophagy COX Prostaglandin Receptor Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na ⁺/H ⁺-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

HY-N1443

Demethylcantharidate disodium	Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer .

HY-W013514

2-Acetamidofluorene	Others	Cancer
2-Acetamidofluorene is a potent carcinogenan. 2-Acetamidofluorene is can be used fot induction of hepatocellular carcinoma (HCC) and multiple primary tumours .

HY-101840

EIPA 45+ Cited Publications L593754; MH 12-43; Ethylisopropylamiloride	TRP Channel Prostaglandin Receptor Autophagy COX Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also enhances autophagy by inhibiting Na ⁺/H ⁺-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

HY-121794

Avarol (+)-Avarol	Others	Cancer
Avarol is a sesquiterpene hydroquinone that can be isolated from Dysidea avara sponge. Avarol has the potential for the research of ehrlich carcinoma (EC) and cervical cancer (CC-5) .

HY-N8306

Isojacareubin	Bacterial PKC Apoptosis SARS-CoV	Cancer
Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis .

HY-130173

Bafilomycin C1 1 Publications Verification	Bacterial Fungal Na+/K+ ATPase Apoptosis Antibiotic	Infection Cancer
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H ⁺-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi . Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) .

HY-156113

RET-IN-25	RET	Cancer
RET-IN-25 (compound 6b) is a RET kinase inhibitor with anticancer activity. RET-IN-25 inhibits medullary thyroid carcinoma (MTC) with IC₅₀s of 3.6 μM (3 days) and 3.0 μM (6 days) against TT(C634R) MTC .

HY-N10203

Rostratin A	Endogenous Metabolite	Cancer
Rostratin A is a cytotoxic disulfide found in the marine-derived fungus Exserohilum rostratum. Rostratin A shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC₅₀ of 8.5 μg/mL .

HY-P99262

Imalumab BAX69; Anti-Human MIF Recombinant Antibody	Macrophage migration inhibitory factor (MIF)	Cancer
Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody that targets macrophage inhibitory factor (MIF). Imalumab can be used for the research of ovarian carcinoma, recurrent malignant ascites and cancer .

HY-158099

Biotin-Cel Celastrol-Biotin	Biochemical Assay Reagents	Cancer
Biotin-Cel (Celastrol-Biotin) is a biotin-labeled Celastrol (HY-13067). Celastrol exhibits antitumor, anti-inflammatory, and anti-obesity activities. Biotin-Cel can be used in biotin-affinity pulldown assay to identify the molecular target of Celastrol in hepatocellular carcinoma cells .

HY-128366

Waltonitone	Apoptosis	Cancer
Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo .

HY-121532

(-)-Rasfonin	Ras Apoptosis Autophagy	Cancer
(-)-Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-)-Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line) .

HY-W029411

4-(Benzo[d]oxazol-2-yl)aniline	Others	Cancer
4-(Benzo[d]oxazol-2-yl)aniline is a potent antitumor agent. 4-(Benzo[d]oxazol-2-yl)aniline has inhibitory activity against mammary carcinoma cell lines .

HY-19015

Probimane AT-2153	Others	Cancer
Probimane (AT-2153) is a potent anticancer agent. Probimane is effective against mouse tumors S37, S180, Lewis lung carcinoma, L1210 and human pulmonary adenocarcinoma heterotransplanted into nude mice .

HY-149475

VEGFR-2-IN-33	VEGFR	Cancer
VEGFR-2-IN-33 (Compound 4d) is a VEGFR inhibitor (IC₅₀: 61.04 nM). VEGFR-2-IN-33 inhibits HepG2 cell proliferation with an IC₅₀ of 4.31 nM. VEGFR-2-IN-33 can be used for research of hepatocellular carcinoma (HCC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7651

Neoanhydropodophyllol	Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Others
Neoanhydropodophyllol is a cyclolignan derivative, with antineoplastic activity. Neoanhydropodophyllol displays cytotoxicity against several cancer cells (leukemia, lung carcinoma and colon carcinoma) .

HY-P99758

Nofazinlimab CS1003	Classification of Application Fields Disease Research Fields Cancer	PD-1/PD-L1
Nofazinlimab (CS1003) is a humanised IgG4 anti-PD-1 monoclonal antibody. Nofazinlimab can be used for unresectable hepatocellular carcinoma (uHCC) research .

HY-P99231

Edrecolomab Panorex; CO17-1A	Classification of Application Fields Disease Research Fields Cancer	Others
Edrecolomab (Panorex) is a murine monoclonal antibody to the cell-surface glycoprotein 17-1A, expressed on epithelial tissues and on various carcinomas. Edrecolomab shows anti-tumor activity and can be used in colorectal carcinoma research .

HY-P99384

Vofatamab B-701; MFGR-1877S; RG-7444	Classification of Application Fields Disease Research Fields Cancer	FGFR
Vofatamab (B-701) is an anti-FGFR3 monoclonal antibody (mAb). Vofatamab blocks activation of both the wildtype and genetically activated receptor. Vofatamab can be used in the research of metastatic urothelial carcinoma (mUC) .

HY-N4168B

Methyl chlorogenate	Structural Classification Crataegus monogyna Jacq. Source classification Rosaceae Phenols Polyphenols Plants	Others
Methyl chlorogenate is an antioxidant, and has radical scavenging activity. Methyl chlorogenate is an anti-inflammatory agent. Methyl chlorogenate also inhibits hepatocellular carcinoma (HCC) cell proliferation and metastasis .

HY-N10204

Rostratin B	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Endogenous Metabolite
Rostratin B, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC₅₀ of 1.9 μg/mL .

HY-N10205

Rostratin C	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Endogenous Metabolite
Rostratin C, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC₅₀ value of 0.76μg /mL .

HY-N11429

Glycochenodeoxycholic acid 3-glucuronide	Triterpenes Structural Classification Terpenoids Source classification Endogenous metabolite	Endogenous Metabolite
Glycochenodeoxycholic acid 3-glucuronide is a type of steroid glucuronide and a plasma metabolite that can be used in the research of biomarkers for diabetes and hepatocellular carcinoma (HCC) .

HY-N2591A

Isocorydine hydrochloride	Structural Classification Alkaloids Classification of Application Fields Source classification Endogenous metabolite Isoquinoline Alkaloids Disease Research Fields Cancer	Endogenous Metabolite
Isocorydine hydrochloride is isolated from Dicranostigma leptopodum (Maxim.) Fedde (DLF). Isocorydine hydrochloride combines with Doxorubicin (DOX) has a promising potential to eradicate hepatocellular carcinoma (HCC) .

HY-N6623

Malvidin-3-galactoside chloride	Structural Classification Anthocyans Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Reactive Oxygen Species
Malvidin-3-galactoside chloride, an anthocyanin monomer, induces hepatocellular carcinoma (HCC) cells cycle arrest and apoptosis. Malvidin-3-galactoside chloride inhibits the production and accumulation of ROS. Malvidin-3-galactoside chloride has anti-tumor function .

HY-N1622

1-Dehydroxy-23-deoxojessic acid	Triterpenes Combretaceae Source classification Plants Combretum quadrangulare Kurz	Others
1-Dehydroxy-23-deoxojessic acid (compound 10) is a cycloartane-type triterpene. 1-Dehydroxy-23-deoxojessic acid exhibits cytotoxicity against murine colon 26-L5 carcinoma cells, with an EC₅₀ of 62.38 μM .

HY-133100

5-ALA benzyl ester hydrochloride Benzyl-ALA hydrochloride	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines .

HY-N1443

Demethylcantharidate disodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis
Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer .

HY-121794

Avarol (+)-Avarol	Structural Classification Monophenols Marine natural products Source classification Phenols	Others
Avarol is a sesquiterpene hydroquinone that can be isolated from Dysidea avara sponge. Avarol has the potential for the research of ehrlich carcinoma (EC) and cervical cancer (CC-5) .

HY-N8306

Isojacareubin	Structural Classification Flavonoids Flavones Source classification Guttiferae Plants Hypericum japonicum Thunb. ex Murray	Bacterial PKC Apoptosis SARS-CoV
Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis .

HY-130173

Bafilomycin C1 1 Publications Verification	Infection Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields Cancer	Bacterial Fungal Na+/K+ ATPase Apoptosis Antibiotic
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H ⁺-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi . Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) .

HY-N10203

Rostratin A	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Marine natural products Disease Research Fields Marine microorganism Cancer	Endogenous Metabolite
Rostratin A is a cytotoxic disulfide found in the marine-derived fungus Exserohilum rostratum. Rostratin A shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC₅₀ of 8.5 μg/mL .

HY-P99262

Imalumab BAX69; Anti-Human MIF Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	Macrophage migration inhibitory factor (MIF)
Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody that targets macrophage inhibitory factor (MIF). Imalumab can be used for the research of ovarian carcinoma, recurrent malignant ascites and cancer .

HY-128366

Waltonitone	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo .

HY-121532

(-)-Rasfonin	Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	Ras Apoptosis Autophagy
(-)-Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-)-Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line) .

HY-P9978

Toripalimab	Classification of Application Fields Disease Research Fields Cancer	PD-1/PD-L1
Toripalimab is the first domestic anti-tumor PD-1 antibody in China. Toripalimab is a selective, recombinant, humanized monoclonal antibody against PD-1. Toripalimab is able to bind to PD-1 and block the interaction with its ligands. Toripalimab has exhibited primary anti-tumor effects in tumors such as melanoma, lung cancer, digestive tract tumors, hepatobiliary and pancreatic tumors, neuroendocrine neoplasms, nasopharyngeal carcinoma and urothelial carcinoma .

HY-P99023

Girentuximab G250; cG250	Classification of Application Fields Disease Research Fields Cancer	Carbonic Anhydrase
Girentuximab (G250) is a chimeric monoclonal antibody that binds carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC) .

HY-N2779

8-Lavandulylkaempferol	Structural Classification Flavonoids Flavones Leguminosae Source classification Plants Sophora flavescens Aiton	Others
8-Lavandulylkaempferol is a flavonoid that can be isolated from Sophora flaWescens. 8-Lavandulylkaempferol exhibits cytotoxic activity against the KB epidermoid carcinoma cell line with an IC₅₀ of 15.1 μg/mL .

HY-P99016

Enfortumab	Classification of Application Fields Disease Research Fields Cancer	ADC Antibody Nectin-4
Enfortumab is a humanized derived anti-Nectin-4 antibody that can be conjugated with the highly efficient microtubule disruptor MMAE (HY-15162) to generate the antibody drug conjugate (ADC) Enfortumab vedotin (HY-P99016A). Enfortumab can be used for the study of locally advanced and metastatic urothelial carcinoma .

HY-133168

Englerin A	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields Cancer	TRP Channel
Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC₅₀s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca ²⁺ influx and Ca ²⁺ cell overload .

HY-P99544

Tagitanlimab HBM-9167; KL-A167	Classification of Application Fields Disease Research Fields Cancer	PD-1/PD-L1
Tagitanlimab (HBM-9167) is a humanized anti-PD-L1 antibody (IgG1κ type). Tagitanlimab selectively blocks the interaction of PD-L1 and PD-1. Tagitanlimab has the potential to be studied in recurrent or metastatic nasopharyngeal carcinoma (NPC) .

HY-N8394

Eupatolide	Source classification Plants Compositae Guilandina minax (Hance) G. P. Lewis	Others
Eupatolide is an antitumor agent that can be isolated from Eupatorium formosanum. Eupatolide has cytotoxic activity and inhibits human epidermoid carcinoma of larynx cell growth in vitro .

HY-N6623R

Malvidin-3-galactoside chloride (Standard)	Structural Classification Anthocyans Flavonoids other families Source classification Phenols Polyphenols Plants	Apoptosis Endogenous Metabolite Reactive Oxygen Species
Malvidin-3-galactoside (chloride) (Standard) is the analytical standard of Malvidin-3-galactoside (chloride). This product is intended for research and analytical applications. Malvidin-3-galactoside chloride, an anthocyanin monomer, induces hepatocellular carcinoma (HCC) cells cycle arrest and apoptosis. Malvidin-3-galactoside chloride inhibits the production and accumulation of ROS. Malvidin-3-galactoside chloride has anti-tumor function .

HY-123901

Garcinone E	Structural Classification Flavonoids Source classification Guttiferae Garcinia mangostana Linn. Plants Other Flavonoids	Apoptosis
Garcinone E is a natural xanthone found in the rind of the mangosteen fruit. Garcinone E induces apoptosis and inhibits cancer cell migration. Garcinone E has anticancer effects on different human cancer cell lines, including colorectal, breast, and hepatocellular carcinomas .

HY-17556A

Folinic acid disodium Leucovorin disodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Antifolate
Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma .

HY-P99208

Lirilumab 2 Publications Verification IPH2102	Classification of Application Fields Disease Research Fields Cancer	Others
Lirilumab (IPH2102) is an anti-KIR monoclonal antibody, and shows antitumor activity. Lirilumab can be used in Leukemia, squamous cell carcinoma of the head and neck (SCCHN) research .

HY-133168R

Englerin A (Standard)	Structural Classification other families Terpenoids Sesquiterpenes Source classification Plants	TRP Channel
Englerin A (Standard) is the analytical standard of Englerin A. This product is intended for research and analytical applications. Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC₅₀s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload .

HY-N10535

Lewis y tetrasaccharide Lewis y	Structural Classification Polysaccharides Classification of Application Fields Endogenous metabolite Disease Research Fields Saccharides Cancer	FAK
Lewis Y tetrasaccharide (Lewis Y, Le ^Y) is a tetrasaccharide derivative form of Lewis X trisaccharide (HY-N10534). Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis .

HY-P99013

Codrituzumab GC33; RO5137382	Classification of Application Fields Disease Research Fields Cancer	Others
Codrituzumab (GC33) is a humanized monoclonal antibody targeting human GPC3 (glypican-3), with high affinity (K_d of 0.673 nM). GPC3 is an oncofetal protein expressed on the cell surface of hepatocellular carcinoma (HCC). Codrituzumab induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth .

HY-N2334

Glycochenodeoxycholic acid 3 Publications Verification Chenodeoxycholylglycine	Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Endogenous Metabolite Apoptosis STAT BCL6 Interleukin Related Caspase
Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .

HY-N2334A

Glycochenodeoxycholic acid sodium salt 3 Publications Verification Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Endogenous Metabolite Apoptosis STAT BCL6 Interleukin Related Caspase
Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .

HY-P9972

Spartalizumab PDR001	Classification of Application Fields Disease Research Fields Cancer	PD-1/PD-L1
Spartalizumab (PDR001) is a humanized immunoglobulin 4 monoclonal antibody that binds PD-1 with subnanomolar activity and blocks interaction with PD-L1 and PD-L2. Spartalizumab can be used for the research of anaplastic thyroid carcinoma (ATC) .

HY-P99161

Tilvestamab BGB149	Classification of Application Fields Disease Research Fields Cancer	TAM Receptor
Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits Gas6-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas .

HY-P99035

Naptumomab	Classification of Application Fields Disease Research Fields Cancer	Others
Naptumomab is a fusion protein of a tumor-targeting superantigen (TTS). Naptumomab stimulates the immune system to recognize and kill tumor cells and can be used in the study of refractory solid tumors such as renal cell carcinoma .

HY-N0462

Corilagin 4 Publications Verification	Phyllanthus urinaria Linn. Infection Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	Toll-like Receptor (TLR) Reverse Transcriptase Bacterial Apoptosis Autophagy
Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular carcinoma and ovarian cancer model. Corilagin shows low toxicity to normal cells and tissues .

HY-N6885

Puerarin-4'-O-β-D-glucopyranoside	Flavonoids Monophenols Classification of Application Fields Leguminosae Source classification Phenols Pueraria montana (Loureiro) Merrill Plants Disease Research Fields Isoflavones Cancer	Others
Puerarin-4'-O-β-D-glucopyranoside (compound 8) is a isoflavone from Pueraria lobata root (PLR). Puerarin-4'-O-β-D-glucopyranoside has estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells .

HY-N7073

Silymarin 5 Publications Verification	Infection Structural Classification Natural Products Glycine soya Neurological Disease Classification of Application Fields Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Inflammation/Immunology Disease Research Fields	SARS-CoV
Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective SARS-CoV-2 main protease (M ^pro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research .

HY-17473

Embelin 4 Publications Verification Embelic acid; Emberine; NSC 91874	Quinones Structural Classification Classification of Application Fields Source classification Benzene Quinones Embelia laeta (Linn.) Mez Plants Myrsinaceae Disease Research Fields Cancer	IAP NF-κB Apoptosis Autophagy
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC₅₀=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells .

HY-N0462R

Corilagin (Standard)	Phyllanthus urinaria Linn. Structural Classification Source classification Phenols Polyphenols Euphorbiaceae Plants	Toll-like Receptor (TLR) Reverse Transcriptase Bacterial Apoptosis Autophagy
Corilagin (Standard) is the analytical standard of Corilagin. This product is intended for research and analytical applications. Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular carcinoma and ovarian cancer model. Corilagin shows low toxicity to normal cells and tissues .

HY-P99933

Eftilagimod alfa IMP321; LAG-3Ig	Classification of Application Fields Disease Research Fields Cancer	LAG-3
Eftilagimod alfa (IMP321) is a recombinant LAG-3Ig fusion protein that binds to MHC class II. Eftilagimod alfa mediates antigen-presenting cell (APC) activation followed by CD8 T-cell activation. Eftilagimod alfa can be used for metastatic melanoma and metastatic breast carcinoma research .

HY-N12960

Artobiloxanthone	Structural Classification Source classification Phenols Polyphenols Plants Moraceae Artocarpus altilis (Parkinson) Fosberg	Apoptosis Bcl-2 Family Caspase COX MMP STAT
Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). Artobiloxanthone inhibits Akt/mTOR pathway and STAT3 pathway, inhibits proliferation of SAS and T.Tn (with IC₅₀ of 11 and 22 μM), and inhibits the cancer cell migration. Artobiloxanthone arrests cell cycle at S phase, and induces apoptosis in OSCC cells through activation of caspase 3/9 .

HY-P99406

Petosemtamab MCLA 158	Classification of Application Fields Disease Research Fields Cancer	EGFR
Petosemtamab (MCLA 158) is an anti- EGFR (K_d: 0.22 nM) and anti-LGR5 (K_d: 0.86 nM) monoclonal antibody (mAb). Petosemtamab leads to EGFR signaling blockade and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC) .

HY-B1247

Protoporphyrin IX 10+ Cited Publications	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Protoporphyrin IX is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma .

HY-B0986

Hexylresorcinol 4-Hexylresorcinol	Infection Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Parasite Bacterial Apoptosis Glucosidase Endogenous Metabolite
Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage .

HY-17473R

Embelin (Standard)	Quinones Structural Classification Source classification Benzene Quinones Embelia laeta (Linn.) Mez Plants Myrsinaceae	IAP NF-κB Apoptosis Autophagy
Embelin (Standard) is the analytical standard of Embelin. This product is intended for research and analytical applications. Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells .

Cat. No.	Product Name	Chemical Structure

HY-13702S

Nilutamide-d6
Nilutamide-d₆ (Nilandron-d6) is the deuterium labeled Nilutamide. Nilutamide (Nilandron) is a non-steroidal anti-androgen agent proposed in the research of metastatic prostatic carcinoma[1][2].

HY-N0610AS

Cinnamic acid-d6
Cinnamic acid-d₆ is the deuterium labeled Cinnamic acid. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.

HY-N0610AS2

Cinnamic acid-13C3
Cinnamic acid- ¹³C₃ (3-Phenylacrylic acid- ¹³C₃) is the ¹³C labeled Cinnamic acid (HY-N0610A). Cinnamic acid has potential use in cancer intervention, with IC₅₀s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells .

HY-B0185AS

Lidocaine-d10 hydrochloride

Lidocaine-d₁₀ (hydrochloride) is the deuterium labeled Lidocaine hydrochloride. Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride, an amide derivative, has the potential for the research of the ventricular arrhythmia[2].

HY-B0185S1

Lidocaine-d10

Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].

HY-161679S

Pyruvate Carboxylase-IN-3
Pyruvate Carboxylase-IN-3 (Compd 36) is a potent Pyruvate Carboxylase inhibitor. Pyruvate Carboxylase-IN-3 inhibits hepatocellular carcinoma cells activity with an IC₅₀ of 4.3 μM .

HY-119419S

Pirimicarb-d6
Pirimicarb-d₆ is the deuterium labeled Diuron. Diuron is a phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (2,500 ppm, dietary) increases the incidence of urinary bladder urothelial carcinomas in male

HY-13593S

Chlorambucil-d8
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-13593S1

Chlorambucil-d8-1
Chlorambucil-d₈-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-13762S

Tesmilifene-d4
Tesmilifene-d4 is the deuterium labeled Tesmilifene (HY-13762). Tesmilifene is an antihistamine agent and a chemical sensitizer. Tesmilifene targets cytochrome P450, exhibits hormonal effects on DNA synthesis in MCF-7 cells, and stimulates the tumor growth in mouse/rat models. Tesmilifene overcomes multidrug resistance .

HY-B0185S

Lidocaine-d10 N-Oxide

N-Oxide Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].

HY-B0185AS1

Lidocaine-d6 hydrochloride

Lidocaine-d₆ (hydrochloride) is deuterium labeled Lidocaine (hydrochloride). Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor[2].

HY-109015S

Tucidinostat-d4
Tucidinostat-d₄ is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively[1].

HY-13653S1

(-)-Epigallocatechin Gallate-d4

(-)-Epigallocatechin Gallate-d4 (EGCG-d4) is the deuterium labeled (-)-Epigallocatechin Gallate (HY-13653). (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

HY-13690S1

Mitotane-13C6

Mitotane- ¹³C₆ is the ¹³C labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].

HY-13690S2

Mitotane-d8

Mitotane-d₈ is the deuterium labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].

HY-129812

Borofalan
Borofalan- ¹⁰B can be used for Boron neutron capture research (BNCT). Borofalan- ¹⁰B can be used for the research of recurrent or locally advanced head and neck cancer .

HY-17386S1

Rosiglitazone-d4
Rosiglitazone-d₄ is deuterated labeled Rosiglitazone (HY-17386). Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC₅₀: 60 nM, K_d: 40 nM). Rosiglitazone is an TRPC5 activator (EC₅₀: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer .

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