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ProRS

" in MedChemExpress (MCE) Product Catalog:

861

Inhibitors & Agonists

3

Screening Libraries

22

Fluorescent Dye

7

Biochemical Assay Reagents

334

Peptides

1

MCE Kits

10

Inhibitory Antibodies

111

Natural
Products

32

Isotope-Labeled Compounds

16

Click Chemistry

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108137
    Z-LVG-CHN2
    2 Publications Verification

    		 Cathepsin HSV SARS-CoV Infection Inflammation/Immunology
    Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease .
    Z-LVG-CHN2
  • HY-P1434
    [Pro3]-GIP (mouse)

    		Insulin Receptor Metabolic Disease
    [Pro3]-GIP (mouse) is a GIP receptor antagonist (IC50: 2.6 μM). [Pro3]-GIP (mouse) improves glucose tolerance and insulin sensitivity in ob/ob mice. [Pro3]-GIP (mouse) can be used for research of type 2 diabetes .
    [Pro3]-GIP (mouse)
  • HY-P4486
    H-Pro-Gly-Pro-OH

    		Drug Derivative Others
    H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia .
    H-Pro-Gly-Pro-OH
  • HY-P3792
    Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp)

    		Biochemical Assay Reagents Others
    Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) is a FRET substrate of Thimet oligopeptidase. Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) can be used for the determination of Thimet oligopeptidase activity .
    Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp)
  • HY-151880
    Antibacterial agent 124

    		DNA/RNA Synthesis Infection
    Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC50 of 0.18 μM against Staphylococcus aureus ProRS (SaProRS) .
    Antibacterial agent 124
  • HY-N15365
    Antcin B

    		Virus Protease SARS-CoV Infection
    Antcin B is a SARS-CoV-2 3-chymotrypsin-like protease (3CL Pro) inhibitor. Antcin B binds to multiple key amino acid residues of 3CL Pro(such as Leu141, Asn142, Glu166, His163, etc.) through hydrogen bonds, salt bridges, and hydrophobic interactions, thereby inhibiting the activity of 3CL Pro, blocking the cleavage process of viral polyproteins, and suppressing the replication of the SARS-CoV-2 virus in host cells. Antcin B is promising for research of COVID-19 .
    Antcin B
  • HY-108137A
    Z-L(D-Val)G-CHN2

    		Cathepsin HSV SARS-CoV Infection
    Z-L(D-Val)G-CHN2 is the isoform of Z-LVG-CHN2 (HY-108137). Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease .
    Z-L(D-Val)G-CHN2
  • HY-155995
    PRO-905

    MK-905

    		 Biochemical Assay Reagents Cancer
    Pro-905 is a phosphite peptide with antitumor activity. Pro-905 delivers the active nucleotide antimetabolite thioguanosine monophosphate (TGMP) to the tumor. Pro-905 effectively prevents incorporation of purine salvage substrates into nucleic acids and inhibits colony formation in human malignant peripheral nerve sheath tumors (MPNST) cells. Pro-905 inhibits purine salvage incorporation to nucleic acids and prevents cell growth. Pro-905 inhibits the growth of MPNST and enhances the anti-tumor efficacy of JHU395 (HY-124778) .
    PRO-905
  • HY-P4846
    Ac-Pro-Gly-Pro-OH

    		CXCR Inflammation/Immunology
    Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis .
    Ac-Pro-Gly-Pro-OH
  • HY-P4474
    Pz-Pro-Leu-Gly-Pro-d-Arg

    		Bacterial Infection
    Pz-Pro-Leu-Gly-Pro-d-Arg is a synthetic substrate of bacterial collagenase. Pz-Pro-Leu-Gly-Pro-d-Arg can be used to test bacterial collagenase activity .
    Pz-Pro-Leu-Gly-Pro-d-Arg
  • HY-W041990
    Fmoc-Pro-Pro-OH

    		Amino Acid Derivatives Others
    Fmoc-Pro-Pro-OH is a proline derivative .
    Fmoc-Pro-Pro-OH
  • HY-P10291
    [Pro34]Neuropeptide Y, porcine

    		Neuropeptide Y Receptor Neurological Disease
    [Pro34]Neuropeptide Y, porcine is a selective NPY receptor (Y1 receptor) agonist. [Pro34]Neuropeptide Y, porcine evokes vasoconstrictions in the guinea pig caval vein .
    [Pro34]Neuropeptide Y, porcine
  • HY-P4487
    H-Pro-Pro-Asp-NH2

    		Biochemical Assay Reagents Others
    H-Pro-Pro-Asp-NH2 is a potent and selective catalyst for asymmetric aldol reactions. H-Pro-Pro-Asp-NH2 catalyzes aldol reactions between acetone and several aldehydes .
    H-Pro-Pro-Asp-NH2
  • HY-P10391
    Ser-Ala-Pro

    		Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    Ser-Ala-Pro is an X-Pro structure specific angiotensin-converting enzyme (ACE) inhibitory peptide. Ser-Ala-Pro has the potential for hypertension research .
    Ser-Ala-Pro
  • HY-P3877A
    (Leu31,Pro34)-Peptide YY (human) (TFA)

    		Neuropeptide Y Receptor Neurological Disease
    (Leu31,Pro34)-Peptide YY (human) (TFA) is the TFA form of (Leu31,Pro34)-Peptide YY (human) (HY-P3877). (Leu31,Pro34)-Peptide YY (human) (TFA) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y1 agonist with a KD of 1.0 nM .
    (Leu31,Pro34)-Peptide YY (human) (TFA)
  • HY-P10304
    Cyclo(Arg-Pro)

    Cyclo(Pro-Arg)

    		 Fungal Others
    Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) is an inhibitor for chitinase. Cyclo(Arg-Pro) inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) inhibits the morphological change of Candida albicans from yeast form to filamentous form .
    Cyclo(Arg-Pro)
  • HY-P0208
    [Leu31,Pro34]-Neuropeptide Y (porcine)
    1 Publications Verification

    		 Neuropeptide Y Receptor Neurological Disease
    [Leu31,Pro34]- Neuropeptide Y (porcine), a Neuropeptide Y (NPY) analog, is a selective NPY Y1 receptor agonist. [Leu31,Pro34]- Neuropeptide Y (porcine) exhibits anxiolytic effects .
    [Leu31,Pro34]-Neuropeptide Y (porcine)
  • HY-P5017
    (Val3,Pro8)-Oxytocin

    		Oxytocin Receptor Endocrinology
    (Val3,Pro8)-Oxytocin is the Gq-dependent pathway agonist. (Val3,Pro8)-Oxytocin is also a weaker agonist for the β-arrestin engagement and endocytosis toward the oxytocin receptor (OXTR) .
    (Val3,Pro8)-Oxytocin
  • HY-P4308
    Z-Pro-Pro-aldehyde-dimethyl acetal

    		Prolyl Endopeptidase (PREP) Neurological Disease
    Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease .
    Z-Pro-Pro-aldehyde-dimethyl acetal
  • HY-W337672
    H-Pro-Hyp-OH

    		Biochemical Assay Reagents Others
    H-Pro-Hyp-OH is a collagen peptide composed of proline (Pro) and hydroxyproline (Hyp). H-Pro-Hyp-OH can be used in research on slowing down facial aging .
    H-Pro-Hyp-OH
  • HY-W013780S3
    Fmoc-Pro-OH-d3

    		Isotope-Labeled Compounds Others
    Fmoc-Pro-OH-d3 is the deuterium labeled Fmoc-Pro-OH.
    Fmoc-Pro-OH-d3
  • HY-P1323
    [Leu31,Pro34]-Neuropeptide Y (human,rat)

    		Neuropeptide Y Receptor Cardiovascular Disease Neurological Disease
    [Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific neuropeptide Y Y1 receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y4, Y5. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake .
    [Leu31,Pro34]-Neuropeptide Y (human,rat)
  • HY-P6023
    D-Leu-Pro-Arg-Rh110-D-Pro

    		Factor Xa Cardiovascular Disease
    D-Leu-Pro-Arg-Rh110-D-Pro is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro can be used to detect FXIa activity .
    D-Leu-Pro-Arg-Rh110-D-Pro
  • HY-P4990
    Pro8-Oxytocin

    		Oxytocin Receptor Endocrinology
    Pro8-Oxytocin is a a modified oxytocin (OXT) ligand. Pro8-Oxytocin produces more potent and efficacious responses at primate OXTR and stronger behavioral effects than the consensus mammalian OXT ligand (Leu8-Oxytocin). Pro8-Oxytocin produce a less efficacious response than Vasopressin (HY-B1811) (AVP) at human AVPR1a and higher efficacious response than AVP at marmoset AVPR1a .
    Pro8-Oxytocin
  • HY-P6023B
    D-Leu-Pro-Arg-Rh110-D-Pro acetate

    		Factor Xa Cardiovascular Disease
    D-Leu-Pro-Arg-Rh110-D-Pro acetate is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro acetate consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro acetate can be used to detect FXIa activity .
    D-Leu-Pro-Arg-Rh110-D-Pro acetate
  • HY-P1323A
    [Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA
    1 Publications Verification

    		 Neuropeptide Y Receptor Cardiovascular Disease Neurological Disease
    [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y1 receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y4, Y5. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake .
    [Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA
  • HY-N9362R
    Emodinanthrone (Standard)

    		Antibiotic Infection
    Pro-xylane (Standard) is the analytical standard of Pro-xylane. This product is intended for research and analytical applications. Pro-xylane (Hydroxypropyl tetrahydropyrantriol) is a biologically active C-glycoside in aqueous media, acts as an activator of glycosaminoglycans (GAGs) biosynthesis. Pro-xylane is the first example of 'Green' chemical used in cosmetic .
    Emodinanthrone (Standard)
  • HY-P3948
    Fluorescent Substrate for Pro-Specific Proteases

    		Fluorescent Dye Others
    Fluorescent Substrate for Pro-Specific Proteases is a fluorescent substrate of pro-specific proteases. Fluorescent Substrate for Pro-Specific Proteases can be used to detect the hydrolysis rate and activity of target enzyme .
    Fluorescent Substrate for Pro-Specific Proteases
  • HY-12290
    Arg-Gly-Asp-Ser
    5 Publications Verification

    RGDS peptide; Fibronectin tetrapeptide

    		 Integrin Inflammation/Immunology
    Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.
    Arg-Gly-Asp-Ser
  • HY-P10304A
    Cyclo(Arg-Pro) TFA

    Cyclo(Pro-Arg) TFA

    		 Fungal Infection
    Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) TFA is a chitinase inhibitor. Cyclo(Arg-Pro) TFA inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) TFA inhibits the morphological change of Candida albicans from yeast form to filamentous form .
    Cyclo(Arg-Pro) TFA
  • HY-P4294
    H-Gly-Pro-Gly-OH

    		Amino Acid Derivatives Others
    H-Gly-Pro-Gly-OH is a tripeptide containing glycine and proline. H-Gly-Pro-Gly-OH can be used for the synthesis of other polypeptides, such as (Pro Gly Gly)n .
    H-Gly-Pro-Gly-OH
  • HY-P4990A
    Pro8-Oxytocin TFA

    		Oxytocin Receptor Endocrinology
    Pro8-Oxytocin TFA is a a modified oxytocin (OXT) ligand. Pro8-Oxytocin produces more potent and efficacious responses at primate OXTR and stronger behavioral effects than the consensus mammalian OXT ligand (Leu8-Oxytocin). Pro8-Oxytocin TFA produce a less efficacious response than Vasopressin (HY-B1811) (AVP) at human AVPR1a and higher efficacious response than AVP at marmoset AVPR1a .
    Pro8-Oxytocin TFA
  • HY-P6023A
    D-Leu-Pro-Arg-Rh110-D-Pro TFA

    		Factor Xa Cardiovascular Disease
    D-Leu-Pro-Arg-Rh110-D-Pro TFA is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro TFA consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro TFA can be used to detect FXIa activity .
    D-Leu-Pro-Arg-Rh110-D-Pro TFA
  • HY-160506
    PRO-6E

    		PROTACs c-Met/HGFR Apoptosis Cancer
    PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note:(Blue: Cereblon ligand (HY-103596), Black: linker；Pink: ALK/c-Met inhibitor Crizotinib (HY-50878)) .
    PRO-6E
  • HY-152101
    LY1

    		SARS-CoV Infection
    LY1 is a potent, selective and covalent inhibitor against both SARS-CoV-2 PL pro and M pro with Kd values of 1.5 μM and 2.3 μM for M pro C145A protein and PL pro C111A protein, respectively. LY1 potent against the viral proteases, with IC50s of 0.12 μM and 0.99 μM against M pro and PL pro. LY1 shows high selectivity over other kinases, human proteases and metalloenzyme .
    LY1
  • HY-W012908S2
    H-DL-Pro-OH-d3

    		Isotope-Labeled Compounds Others
    H-DL-Pro-OH-d3 is the deuterium labeled H-DL-Pro-OH.
    H-DL-Pro-OH-d3
  • HY-12290A
    Arg-Gly-Asp-Ser TFA

    RGDS peptide TFA; Fibronectin tetrapeptide TFA

    		 Integrin Inflammation/Immunology
    Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .
    Arg-Gly-Asp-Ser TFA
  • HY-W016887R
    Glycyl-L-proline (Standard)

    H-Gly-Pro-OH (Standard)

    		 Endogenous Metabolite Metabolic Disease
    H-Gly-Pro-OH (Standard) is the analytical standard of H-Gly-Pro-OH. This product is intended for research and analytical applications. H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.
    Glycyl-L-proline (Standard)
  • HY-P2718
    Z-Gly-Pro-Gly-Gly-Pro-Ala-OH

    		Biochemical Assay Reagents Others
    Z-Gly-Pro-Gly-Gly-Pro-Ala-OH is a collagenase substrate that induces planulae to settle .
    Z-Gly-Pro-Gly-Gly-Pro-Ala-OH
  • HY-108036A
    (S)-Pro-xylane

    (S)-Hydroxypropyl tetrahydropyrantriol

    		 Biochemical Assay Reagents Others
    (S)-Pro-xylane ((S)-Hydroxypropyl tetrahydropyrantriol) is the S-enantiomer of Pro-xylane (HY-108036). Pro-xylane (Hydroxypropyl tetrahydropyrantriol) is a biologically active C-glycoside in aqueous media, acts as an activator of glycosaminoglycans (GAGs) biosynthesis. Pro-xylane has potential skin anti-aging properties and is eco-friendly, biodegradable, and can be used in cosmetic research .
    (S)-Pro-xylane
  • HY-P1937
    Cyclo(-Met-Pro)

    		Influenza Virus Infection
    Cyclo(-Met-Pro) is a cyclic dipeptide consisting of the amino acids methionine and proline. Cyclo(-Met-Pro) exhibits weak inhibitory activity against the influenza A virus (H3N2) (5 mM, 2.1% inhibition), while cis-cyclo(Leu-Pro) and cis-cyclo(Phe-Pro) shows significant antiviral activity .
    Cyclo(-Met-Pro)
  • HY-P4488
    H-Pro-Pro-Gln-OH

    		Dipeptidyl Peptidase Others
    H-Pro-Pro-Gln-OH is a oligopeptide with excellent dipeptidyl peptidase-IV (DPP-IV) inhibitory activity .
    H-Pro-Pro-Gln-OH
  • HY-P3584
    (Pro3) GIP, human

    (Pro3) Gastric Inhibitory Peptide, human

    		 Insulin Receptor Metabolic Disease
    (Pro3) GIP, human ((Pro3) Gastric Inhibitory Peptide, human) is an efficacious, stable and specific human GIP receptor (hGIPR) full agonist. (Pro3) GIP, human has high binding affinity for human GIPR with Ki/ Kd values of 0.90 nM. (Pro3) GIP, human can be used for the research of obesity-related diabetes .
    (Pro3) GIP, human
  • HY-144648
    Mpro/PLpro-IN-1

    		SARS-CoV Infection
    Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of M pro/PL pro. Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus M pro (IC50 = 1.72 μM) and submicromolar potency versus PL pro (IC50 = 0.67 μM) .
    Mpro/PLpro-IN-1
  • HY-144062
    INSCoV-614(1B)

    		SARS-CoV Infection
    INSCoV-614(1B) is a potent inhibitor of M pro (3CL pro). Proteases (PL pro and 3CL pro) are involved with transcription and replication of the virus. INSCoV-614(1B) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1) .
    INSCoV-614(1B)
  • HY-171060
    Mc-Pro-PAB-MMAE

    		Drug-Linker Conjugates for ADC Cancer
    Mc-Pro-PAB-MMAE is a Drug-Linker Conjugate for ADC. Mc-Pro-PAB-MMAE consists of Monomethyl auristatin E (HY-15162) and a linker. Mc-Pro-PAB-MMAE can be used for synthesis of ADCs .
    Mc-Pro-PAB-MMAE
  • HY-P4611
    Z-Pro-Ala

    		Carboxylesterase (CES) Others
    Z-Pro-Ala is an acid carboxypeptidase. Z-Pro-Ala can be isolated from grains and leaves of wheat, Triticum aestivum L .
    Z-Pro-Ala
  • HY-115820
    Cyclo(Pro-Pro)

    		Others Others
    Cyclo(Pro-Pro) is a Alkaloids product that can be isolated from From Nigrospora sp.Z18-17 .
    Cyclo(Pro-Pro)
  • HY-P1938
    Cyclo(L-Pro-L-Val)

    		Bacterial Infection
    Cyclo(L-Pro-L-Val) is a 2,5-diketopiperazine, with toxic activity against phytopathogenic microorganisms (such as R. fascians LMG 3605). Cyclo(L-Pro-L-Val) shows toxicity similar to Chloramphenicol (HY-B0239) with comparable concentration. Cyclo(L-Pro-L-Val) can also inhibit gram-positive phytopathogenic bacterium. Cyclo(L-Pro-L-Val) has potential development as biopesticide .
    Cyclo(L-Pro-L-Val)
  • HY-144063
    INSCoV-600K(1)

    		SARS-CoV Infection
    INSCoV-600K(1) is a potent inhibitor of M pro (3CL pro). Proteases (PL pro and 3CL pro) are involved with transcription and replication of the virus. INSCoV-600K(1) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1) .
    INSCoV-600K(1)

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