Search Result

Results for "

TNF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TNF Receptor (221) 11β-HSD (1) Acyltransferase (1) ADC Cytotoxin (1) Adenosine Receptor (3) Adrenergic Receptor (7) AIM2 (2) Akt (7) AMPK (4) Amyloid-β (3) Antibiotic (8) AP-1 (1) Apoptosis (56) Atg8/LC3 (3) Autophagy (14) Bacterial (23) Bcl-2 Family (4) Biochemical Assay Reagents (1) c-Fms (1) c-Kit (1) c-Myc (2) Calcium Channel (5) Casein Kinase (3) Caspase (16) CaSR (1) Cathepsin (1) CCR (1) CD6 (1) CDK (2) Chloride Channel (2) Cholinesterase (ChE) (1) Complement System (1) COX (25) Cytochrome P450 (1) Dengue virus (1) Deubiquitinase (2) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (1) Dopamine Receptor (2) Drug-Linker Conjugates for ADC (3) E1/E2/E3 Enzyme (2) EGFR (3) Endogenous Metabolite (16) Epigenetic Reader Domain (1) ERK (11) Estrogen Receptor/ERR (2) Farnesyl Transferase (1) Flavivirus (3) Fluorescent Dye (2) FOXO (1) Fungal (2) G protein-coupled Bile Acid Receptor 1 (1) GABA Receptor (2) Glucocorticoid Receptor (6) GLUT (2) Glutathione Peroxidase (1) GSK-3 (1) HCV (2) HDAC (3) Histamine Receptor (3) Histone Demethylase (4) HIV (4) HIV Protease (1) HSP (1) IAP (2) IFNAR (9) IKK (6) Influenza Virus (2) Integrin (1) Interleukin Related (83) IRAK (6) Isotope-Labeled Compounds (6) JAK (3) JNK (3) Keap1-Nrf2 (6) Lactate Dehydrogenase (1) Leukotriene Receptor (4) Liposome (1) MAP3K (4) MAPKAPK2 (MK2) (2) MEK (1) Melanocortin Receptor (1) Microtubule/Tubulin (1) MMP (13) Monoamine Oxidase (3) mTOR (2) MyD88 (1) NAMPT (1) Necroptosis (5) NF-κB (95) NO Synthase (19) NOD-like Receptor (NLR) (11) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (1) Orexin Receptor (OX Receptor) (1) Oxidative Phosphorylation (1) P-glycoprotein (2) P2Y Receptor (1) p38 MAPK (28) p62 (2) PAK (1) Parasite (6) PARP (2) PD-1/PD-L1 (1) PDGFR (1) PGE synthase (4) Phosphatase (2) Phosphodiesterase (PDE) (20) Phospholipase (1) PI3K (3) PKA (2) PKC (4) Potassium Channel (1) PPAR (4) Prostaglandin Receptor (3) PROTACs (2) Proteasome (3) Pyruvate Kinase (2) Radionuclide-Drug Conjugates (RDCs) (1) Raf (1) Ras (1) Reactive Oxygen Species (16) RIP kinase (11) ROR (1) ROS Kinase (2) SARS-CoV (2) Ser/Thr Protease (1) Sirtuin (5) Small Interfering RNA (siRNA) (3) STAT (1) STING (10) Syk (2) Tau Protein (2) TGF-beta/Smad (1) Thyroid Hormone Receptor (2) Tim3 (1) Toll-like Receptor (TLR) (32) Topoisomerase (3) Trace Amine-associated Receptor (TAAR) (1) TRP Channel (1) Tyrosinase (3) VEGFR (10) Wnt (1)
By Research Areas:	Cancer (165) Cardiovascular Disease (25) Endocrinology (9) Infection (43) Inflammation/Immunology (406) Metabolic Disease (21) Neurological Disease (49)
Click Chemistry:	Azide (2) Alkynes (1)
Oligonucleotides:	Nucleosides and their Analogs (1) Pre-designed siRNA Sets (3) CpG ODNs (9) Phospholipids (1) Antisense Oligonucleotides (2) siRNAs (3)

541

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

153

Natural
Products

104

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: TNF Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-161016

TNF/IFN-γ-IN-1	TNF Receptor IFNAR	Neurological Disease
TNF/IFN-γ-IN-1 (compound TGA) is a dual inhibitor of *TNF* and IFN-γ. TNF/IFN-γ-IN-1 can used in study Alzheimer’s disease .

HY-134471

TNF-α-IN-2 1 Publications Verification	TNF Receptor	Inflammation/Immunology Cancer
TNF-α-IN-2 is a potent and orally active inhibitor of *tumor necrosis factor alpha (TNFα), with an IC₅₀* of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis .

HY-142618

TNF-α-IN-6	TNF Receptor	Inflammation/Immunology
TNF-α-IN-6 (compound 12) is an orally effective allosteric inhibitor of TNFα (K_D = 6.8 nM). TNF-α-IN-6 has anti-inflammatory effects .

HY-160436

TNF-α-IN-15	TNF Receptor	Inflammation/Immunology
TNF-α-IN-15 is a *TNF-α* inhibitor. TNF-α-IN-15 can decrease the *TNF-α* blood levels .

HY-149331

TNF-α-IN-11	TNF Receptor Caspase NF-κB	Inflammation/Immunology
TNF-α-IN-11 (Compound 10) is a *TNF-α* inhibitor with a K_D value of 12.06 μM. TNF-α-IN-11 binds to TNF-α and blocks the activation of TNF-α-trigged caspase and NF-κB signaling pathway. TNF-α-IN-11 inhibits the phosphorylation of IκBα, as well as the nuclear translocation of NF κB p65. TNF-α-IN-11 can be used for research of TNF-α-mediated autoimmune diseases .

HY-160433

TNF-α-IN-12	TNF Receptor	Inflammation/Immunology
TNF-α-IN-12 is a *TNF-α* inhibitor with IC₅₀ of 0.1 μM. TNF-α-IN-12 can decrease the *TNF-α* blood levels .

HY-164102

TNF-α-IN-18	TNF Receptor NF-κB	Inflammation/Immunology
TNF-α-IN-18 (Compound 61) is an inhibitor for *TNF-α* (IC₅₀ of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC₅₀ >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis .

HY-153329

TNF-α-IN-9	TNF Receptor	Others
TNF-α-IN-9 (compound 48) is a analog of NDM-1 inhibitor-3 (HY-150758). TNF-α-IN-9 is a *TNF-α* inhibitor. TNF-α-IN-9 shows low inhibitory activity .

HY-153330

TNF-α-IN-10	Interleukin Related TNF Receptor	Inflammation/Immunology
TNF-α-IN-10 (compound 8a) is a IL-6 and *TNF-α* inhibitor. TNF-α-IN-10 shows anti-inflammatory activity .

HY-160437

TNF-α-IN-16	TNF Receptor	Inflammation/Immunology
TNF-α-IN-16 is a potent TNFα inhibitor with an IC₅₀ of <0.6 μM. TNF-α-IN-16 has antiinflammatory properties (WO2001072735A2; example 18) .

HY-160434

TNF-α-IN-13	TNF Receptor	Inflammation/Immunology
TNF-α-IN-13 is a potent TNFα inhibitor with an IC₅₀ of <0.6 μM. TNF-α-IN-13 has antiinflammatory properties (WO2001072735A2; example 6) .

HY-160435

TNF-α-IN-14	TNF Receptor	Inflammation/Immunology
TNF-α-IN-14 is a potent and selective TNFα inhibitor with an IC₅₀ value of 1.1 µM. TNF-α-IN-14 shows antiinflammatory properties (WO2001072735A2; compound 12) .

HY-160027

TNF-alpha-IN-1	TNF Receptor	Inflammation/Immunology
TNF-alpha-IN-1 (compound 202) is an orally active inhibitor of *TNF-alpha. TNF*-alpha-IN-1 has anti-inflammatory activity which can used in study rheumatoid arthritis, psoriasis, and asthma .

HY-112275

TNF-α-IN-1 1 Publications Verification	TNF Receptor	Inflammation/Immunology Cancer
TNF-α-IN-1 is a *TNF-α* inhibitor extracted from patent US20030096841A1, compound example I-7.

HY-P1875A

TNF-α (46-65), human TFA	TNF Receptor	Cancer
TNF-α (46-65), human (TFA) is a peptide of human TNF-α.

HY-148908

TNF-α-IN-8	TNF Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
TNF-α-IN-8 (compound I-42) is a *TNF-α* inhibitor. TNF-α-IN-8 is an isoindole-imide compound. TNF-α-IN-8 can be used for the research of cancer, heart disease, osteoporosis, inflammatory, allergic and autoimmune diseases . TNF-α-IN-8 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-P1860

TNF-α (31-45), human 5 Publications Verification	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology Cancer
TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis .

HY-110203

R-7050 10+ Cited Publications TNF-α Antagonist III	TNF Receptor	Cancer
R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.

HY-P1860A

TNF-α (31-45), human TFA	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology
TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis .

HY-RS14784

TNF Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNF Human Pre-designed siRNA Set A contains three designed siRNAs for TNF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNF Human Pre-designed siRNA Set A TNF Human Pre-designed siRNA Set A

HY-RS14785

Tnf Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnf Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnf gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnf Mouse Pre-designed siRNA Set A Tnf Mouse Pre-designed siRNA Set A

HY-RS14786

TNF Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNF Rat Pre-designed siRNA Set A contains three designed siRNAs for TNF gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNF Rat Pre-designed siRNA Set A TNF Rat Pre-designed siRNA Set A

HY-168130

TNF-α/IL-1β-IN-1	TNF Receptor Interleukin Related	Cardiovascular Disease
TNF-α/IL-1β-IN-1 (compund 11a) is an anti-inflammatory agent that reduces the expression of *TNF-α* and IL-1β, inhibits oxidative stress and cardiomyocyte apoptosis, has good activity against septic myocardial injury, and improves myocardial blood supply in vivo .

HY-163642

TNF-α agonistic 1	Others	Cancer
TNF-α agonistic 1 (compound 22a) can repolarize tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) from the M2 phenotype to the M1 anti-tumor phenotype .

HY-100211

TAPI-2 4 Publications Verification TNF Protease Inhibitor 2	MMP SARS-CoV	Cancer
TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC₅₀ of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .

HY-P99692

Lenercept p55TNF-R:Ig; Ro 45-2081; TNFR55-IgG1	TNF Receptor	Inflammation/Immunology
Lenercept (Ro 45-2081) is a recombinant fusion protein that consists of the soluble *TNF-receptor* (p55) linked to the Fc portion of human IgG1 .

HY-160412

TNFα activity modulator 3	NF-κB	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
TNFα activity modulator 3 (example 6) is a modulator of TNF activity that inhibits TNFα-induced NF-κB activation and can be utilized in relevant research .

HY-156454

UCB-6876	TNF Receptor	Inflammation/Immunology
UCB-6876 is a TNFα inhibitor and binds to asymmetrical crystal form of the TNF trimer (K_D?=?22 μM) .

HY-147045

UCB-5307	TNF Receptor	Inflammation/Immunology
UCB-5307 is a potent *TNF* signaling inhibitor with a K_D of 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex .

HY-P99772

Onfekafusp alfa L19TNF	TNF Receptor	Cancer
Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research .

HY-P99753

Nerelimomab BAYX1351	TNF Receptor	Infection
Nerelimomab (BAYX1351) is an anti-TNF-α antibody. Nerelimomab can be used for research of sepsis .

HY-P99148

*Anti-Mouse TNF* alpha Antibody (TN3-19.12)**	TNF Receptor	Inflammation/Immunology
Anti-Mouse TNF alpha Antibody is an anti-mouse TNF alpha IgG antibody inhibitor derived from host Rat.

HY-P9908

Adalimumab 5+ Cited Publications Anti-Human TNF-alpha, Human Antibody	TNF Receptor Bacterial	Inflammation/Immunology Cancer
Adalimumab is a human monoclonal IgG1 antibody targeting tumour necrosis factor α (TNF-α).

HY-150219

ODN M326 CpG-ODN M326	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN M326 (CpG-ODN M326) is a potent TLR9 agonist. ODN M326 induces the production of TNF. ODN M326 can be used as a vaccine adjuvant .

HY-P99565

Tengonermin ARENEGYR; NGR-TNF; NGR-hTNF	TNF Receptor	Cancer
Tengonermin (ARENEGYR) is a vascular-targeting agent consisting of the human Tumour Necrosis Factor-α (TNF-α) conjugated with the CNGRCG peptide. Tengonermin increases penetration of intratumoral chemotherapy and T-cell infiltration by modifying the tumour microenvironment .

HY-132248

C5 Lenalidomide Lenalidomide 5'-amine	TNF Receptor	Inflammation/Immunology
C5 Lenalidomide (Lenalidomide 5'-amine) is a thalidomide analog and is a potent inhibitor of TNF-alpha production (IC₅₀=100 μM in LPS stimulated human PBMC) .

HY-108623

Atizoram CP-80,633	Phosphodiesterase (PDE)	Inflammation/Immunology
Atizoram (CP-80,633), a cyclic nucleotide phosphodiesterase (PDE4) inhibitor, elevates plasma cyclic AMP levels and decreases tumor necrosis factor-α (TNFα) production in mice .

HY-N8277

Kdo2-Lipid A ammonium 2 Publications Verification	Toll-like Receptor (TLR) TNF Receptor	Cancer
Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both *TNF* and PGE2 .

HY-19667

BMS-561392 DPC 333	TNF Receptor	Inflammation/Immunology
BMS-561392 is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an ADAM17 blocker. BMS-561392 can be used for research of inflammatory bowel disease .

HY-148141

JPE-1375 1 Publications Verification	Complement System	Inflammation/Immunology
JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC₅₀=6.9 µM) and reduces *TNF* levels (EC₅₀=4.5 µM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases .

HY-120041

ND-2158	IRAK	Cancer
ND-2158 is a competitive IRAK4 inhibitor, with the K_i of 1.3 nM. ND-2158 suppresses LPS-induced TNF production in human white blood cells, alleviated collagen-induced arthritis, and blocked gout formation in mouse models. ND-2158 has antitumor activity in vivo .

HY-100702

SH-5	Akt Apoptosis	Cancer
SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke .

HY-156431

Anti-inflammatory agent 61	TNF Receptor	Inflammation/Immunology
Anti-inflammatory agent 61 (Compound 5b) is a potent anti-inflammatory agent. Anti-inflammatory agent 61 reduces *TNF-α* expression in LPS-induced inflammation in RAW 264.7 cells. Anti-inflammatory agent 61 alleviates APAP-induced inflammation in HepG2 cells .

HY-100211A

(R)-TAPI-2 (R)-TNF Protease Inhibitor 2	Others	Cancer
(R)-TAPI-2 is the isomer of TAPI-2 (HY-100211A). TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC₅₀ of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .

HY-P990008

Atrosab	TNF Receptor Apoptosis	Inflammation/Immunology
Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated apoptosis induction and IL-6 and IL-8 production. Atrosab can be used for research of inflammatory disease .

HY-162734

BRD5075	Interleukin Related	Inflammation/Immunology
BRD5075 is a potent GPR65 activator. BRD5075 induces GPR65-dependent cAMP production. BRD5075 decreases the gene expression of IL-1, IL-2, TNF, and chemokine. BRD5075 has the potential for the research of multiple sclerosis and inflammatory bowel disease (IBD) .

HY-128348

PK68	RIP kinase	Inflammation/Immunology Cancer
PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC₅₀ of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis .

HY-108847

Etanercept 5+ Cited Publications	TNF Receptor Bacterial	Inflammation/Immunology Cancer
Etanercept, a dimeric fusion protein that binds TNF, acts as a *TNF* inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis .

HY-111255

SPD304 5 Publications Verification	TNF Receptor	Cancer
SPD304 is a selective *TNF-α* inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .

HY-111255A

SPD304 dihydrochloride 5 Publications Verification	TNF Receptor	Inflammation/Immunology Cancer
SPD304 dihydrochloride is a selective *TNF-α* inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8277

Kdo2-Lipid A ammonium 2 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Toll-like Receptor (TLR) TNF Receptor
Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both *TNF* and PGE2 .

HY-N0297

Sinensetin 5+ Cited Publications Pedalitin permethyl ether	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Other Diseases Plants Disease Research Fields	PGE synthase TNF Receptor
Sinensetin is a methylated flavonoid found in fruits that has strong anti-vascular and anti-inflammatory properties.

HY-N0509

Astilbin 2 Publications Verification	Flavanonols Structural Classification Flavonoids Microorganisms other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Keap1-Nrf2 TNF Receptor NF-κB
Astilbin is a flavonoid compound and enhances NRF2 activation. Astilbin also suppresses *TNF-α* expression and NF-κB activation.

HY-N2252

Licarin A (+)-Licarin A	Structural Classification Neurological Disease Classification of Application Fields Saururus chinensis (Lour.) Baill. Source classification Plants Monophenols Saururaceae Simple Phenylpropanols Phenols Phenylpropanoids Inflammation/Immunology Disease Research Fields	TNF Receptor Prostaglandin Receptor COX
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC₅₀=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces *TNF-α* and PGD2 production, and COX-2 expression .

HY-N0472

Geraniin 2 Publications Verification	Phyllanthus urinaria Linn. Structural Classification Classification of Application Fields Source classification Other Phenylpropanoids Metabolic Disease Plants Phenols Polyphenols Euphorbiaceae Phenylpropanoids Inflammation/Immunology Disease Research Fields	TNF Receptor
Geraniin is a *TNF-α* releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC₅₀ of 43 μM.

HY-N3595

Cleomiscosin A	Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Euphorbiaceae Phenylpropanoids Plants Macaranga adenantha Gagnep. Inflammation/Immunology Disease Research Fields	TNF Receptor
Cleomiscosin A is a coumarino-lignoid from branch of Macaranga adenantha. Cleomiscosin A is active against *TNF-alpha* secretion of the mouse peritoneal macrophages .

HY-108953

(S)-Quinolactacine A	Alkaloids Microorganisms Classification of Application Fields Source classification Quinoline Alkaloids Disease Research Fields Inflammation/Immunology	Others
(S)-Quinolactacine A is a TNF production inhibitor .

HY-162599

Spirohypertone B	Source classification Hypericaceae Hypericum patulum Thunb. Plants	TNF Receptor
Spirohypertone B is a potent Tumor necrosis factor-α (TNF-α) inhibitor. Spirohypertone B protects L929 cells from death induced by co-incubation with TNF-α and Actinomycin D (HY-17559) .

HY-N6969A

Dicentrine hydrochloride	Structural Classification Alkaloids Other Alkaloids Source classification Stephania epigaea Lo Plants Menispermaceae	Adrenergic Receptor
Dicentrine hydrochloride is a drug with anti-inflammatory and anti-cancer activity. Dicentrine hydrochloride exerts its effects by enhancing TNF-α-induced apoptosis in A549 lung adenocarcinoma cells. Dicentrine hydrochloride increases caspase-8, -9, -3 and poly(ADP-ribose) polymerase (PARP) activities. Dicentrine hydrochloride inhibits TNF-α-induced invasion and migration of A549 cells. Dicentrine hydrochloride significantly inhibited the TNF-α-activated TAK1, p38, JNK and Akt signaling pathways, and reduced the transcriptional activities of NF-κB and AP-1 .

HY-N3625

Coronalolic acid Coronalonic acid	Other Terpenoids Structural Classification Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	NF-κB
Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced NF-κB activity and NO production .

HY-N0358

1,4-Dicaffeoylquinic acid 1 Publications Verification 1,4-DCQA	Caprifoliaceae Classification of Application Fields Lonicera japonica Thunb. Source classification Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology	TNF Receptor Interleukin Related
1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production .

HY-N8816

Stipuleanoside R2	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae Aralia chinensis L.	NF-κB
Stipuleanoside R2 inhibits NF-κB activation stimulated by TNFα in a dose-dependent manner with IC₅₀ value of 4.1 μM .

HY-121401

Myrtenal (±)-Myrtenal	Structural Classification Other Monoterpenes Terpenoids Labiatae Source classification Erythrina poeppigiana Plants	Others
Myrtenal ((±)-Myrtenal) is a monoterpene that acts as an antineoplastic agent. Myrtenal inhibits liver cancer by preventing DEN-PB-induced upregulation of TNF-α protein expression.

HY-N0604

Ginsenoside Rh1 3 Publications Verification Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae	Interleukin Related PPAR TNF Receptor Endogenous Metabolite
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, *TNF-α, IL-6, and IL-1β*.

HY-N9867

Gnetifolin E	Structural Classification Source classification Phenols Polyphenols Gnetaceae Plants Gnetum gnemon var. brunonianum (Griff.) Markgr.	TNF Receptor
Gnetifolin E is a resveratrol trimer derivative that can be isolated from Gnetum brunonianum. Gnetifolin E has anti-inflammatory activity, and inhibits *TNF-α* .

HY-N1125

Triptobenzene H Hypoglic acid	Structural Classification Ketones, Aldehydes, Acids Terpenoids Source classification Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f.	Others
Triptobenzene H (Hypoglic acid) significantly increases TNF-α and IL-1β mRNA levels in macrophages, causing indirect liver damage .

HY-N9315

Episappanol	Other Terpenoids Classification of Application Fields Leguminosae Terpenoids Caesalpinia sappan L. Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	TNF Receptor Interleukin Related
Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the IL-6 and *TNF-α* secretion .

HY-129151

Ganoderic acid C1	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Inflammation/Immunology	Others
Ganoderic acid C1, a natural compound that could be isolated from G. lucidum, suppresses TNF-α production by murine macrophages (RAW 264.7 cells) .

HY-N10453

Sinulatumolin D	Other Terpenoids Animals Source classification	TNF Receptor
Sinulatumolin D (compound 4) is an anti-inflammatory agent. Sinulatumolin D has significant *TNF-α* inhibitory activity with an IC₅₀ value of 5.5 μM .

HY-N10454

Sinulatumolin C	Other Terpenoids Animals Source classification	TNF Receptor
Sinulatumolin C (compound 3) is an anti-inflammatory agent. Sinulatumolin C has significant *TNF-α* inhibitory activity with an IC₅₀ value of 2.6 μM .

HY-N10835

Gnetumontanin B	Structural Classification Source classification Phenols Gnetaceae Plants Gnetum montanum Markgr.	Others
Gnetumontanin B is a stilbenoid that can be found in Gnetum montanum f. megalocarpum. Gnetumontanin B inhibits TNF-α production with an IC₅₀ value of 1.49 µM .

HY-124003

Phytomonic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Phytomonic acid is a long-chain fatty acid containing a cyclopropane ring produced by Lactobacillus reuteri. Lactobacilli that normally produce Lactobacillic acid also have the ability to resist TNF-α .

HY-N11996

Aloenin aglycone	Structural Classification Liliaceae Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants	NO Synthase NF-κB
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC₅₀: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα .

HY-N7637

Tubuloside B 1 Publications Verification	Structural Classification Classification of Application Fields Cistanche salsa (C. A. Mey.) G. Beck Source classification Other Phenylpropanoids Phenols Polyphenols Orobanchaceae Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis
Tubuloside B, one of the phenylethanoids isolated from the stems of Cistanche salsa, inhibits TNFα-induced apoptosis. Tubuloside B possesses antioxidative effects .

HY-N1159

Teuclatriol	Structural Classification Terpenoids Labiatae Sesquiterpenes Source classification Plants Brickellia cavanillesii A.Gray	NF-κB
Teuclatriol is an NF-κB inhibitor can be isolated from salvia mirzayanii, has anti-inflammatory effects. Teuclatriol inhibits TNF-α secretion in a dose-dependent manner .

HY-N6253

Pinoresinol (+)-Pinoresinol	Structural Classification other families Classification of Application Fields Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis
Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .

HY-N0857

Deoxyandrographolide 1 Publications Verification	Andrographis paniculata (Burm. F.) Nees Acanthaceae Terpenoids Source classification Diterpenoids Plants	Interleukin Related
Deoxyandrographolide suppresses LPS induced increase in mRNA levels of iNOS as well as production of proinflammatory mediators TNF-α and IL-6. Deoxyandrographolide potentiates NGF-induced neurite outgrowth .

HY-N10448

Sinulatumolin E	Other Terpenoids Microorganisms Terpenoids Source classification	TNF Receptor
Sinulatumolin E (compound 6), a terpenoid, displays significant *TNF-α* inhibitory activity with an IC₅₀ of 3.6 μM. Sinulatumolin E (compound 6) exhibits anti-inflammatory activity .

HY-N13114

8-Gingerdione	Zingiber officinale Roscoe Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	Others
8-Gingerdione can be isolated from ginger (Zingiber officinale). 8-Gingerdione has no significant inhibitory effect on the production of inflammatory factors NO, TNF-α, and IL-6.

HY-N0907

Ginsenoside Rg6	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	NF-κB Apoptosis
Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

HY-N1949

Homoplantaginin 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Labiatae Source classification Cassia Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	TNF Receptor NF-κB
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit *TNF-α* and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.

HY-N4275

Oleaside A	Apocynaceae Structural Classification Classification of Application Fields Cardiacglycosides Source classification Nerium indicum Mill. Plants Disease Research Fields Steroids Cancer	Others
Oleaside A is a polar cardenolide monoglycoside isolated from Nerium oleander, inhibits the induction of ICAM-1 induced by IL-1α and TNF-α, and has anti-tumor activity .

HY-N0509R

Astilbin (Standard)	Flavanonols Structural Classification Flavonoids Microorganisms other families Source classification Phenols Polyphenols Plants	Keap1-Nrf2 TNF Receptor NF-κB
Astilbin (Standard) is the analytical standard of Astilbin. This product is intended for research and analytical applications. Astilbin is a flavonoid compound and enhances NRF2 activation. Astilbin also suppresses TNF-α expression and NF-κB activation.

HY-N12186

Sibiricine	Structural Classification Alkaloids Source classification Corydalis crispa Prain Plants Isoquinoline Alkaloids Papaveraceae	Others
Sibiricine (Compound 8) is an isoquinoline alkaloid derived from the medicinal plant Corydalis crispa. Sibiricine has significant anti-inflammatory activity on TNF-α production by LPS-activated THP-1 cells .

HY-N0472R

Geraniin (Standard)	Phyllanthus urinaria Linn. Structural Classification Source classification Other Phenylpropanoids Phenols Polyphenols Euphorbiaceae Phenylpropanoids Plants	TNF Receptor
Geraniin (Standard) is the analytical standard of Geraniin. This product is intended for research and analytical applications. Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC₅₀ of 43 μM.

HY-N11768

4-Methoxylonchocarpin	Structural Classification Monophenols Source classification Phenols Plants Moraceae Dorstenia mannii Hook.f.	NF-κB Interleukin Related Toll-like Receptor (TLR)
4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model .

HY-N1940

β-Anhydroicaritin 1 Publications Verification Cycloicaritin	Flavonols Structural Classification Flavonoids Classification of Application Fields Plants Burseraceae Inflammation/Immunology Disease Research Fields Boswellia carterii	Interleukin Related TNF Receptor MMP
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-N0042

Ginsenoside Rc Panaxoside Rc	Panax ginseng C. A. Meyer Triterpenes Structural Classification Neurological Disease Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	GABA Receptor TNF Receptor Interleukin Related
Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptor_A (GABA_A)-mediated ion channel currents (I_GABA). Ginsenoside Rc inhibits the expression of *TNF-α* and IL-1β.

HY-N2110

Phellopterin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Inflammation/Immunology Disease Research Fields	Akt
Phellopterin is a natural product isolated from Angelica dahurica. Phellopterin reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium .

HY-126414

Methylenedihydrotanshinquinone	Calea platylepis Terpenoids Labiatae Diterpenoids Plants	Others
Methylenedihydrotanshinquinone is a natural product that can be isolated from the dried root of S. miltiorrhiza. Methylenedihydrotanshinquinone has anti-inflammatory effect by inhibiting expression of TNF-α, IL-1β, and IL-8 .

HY-N11994

Aloeresin G	Structural Classification Monophenols Liliaceae Source classification Phenols Aloe vera (L.) Burm. f. Plants	TNF Receptor
Aloeresin G is a chromone glycoside that can be isolated from Aloe. Aloeresin G has a weak inhibitory effect on TNFα-induced NF-κB transcriptional activity, with an IC 50 value of 40.02 μM .

HY-N12653

Exserohilone (-)-Exserohilone	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Reactive Oxygen Species
Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced ROS generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts .

HY-N0906

Ginsenoside Rk3	Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	NF-κB
Ginsenoside Rk3 is present in the roots Panax ginseng herbs. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC₅₀ of 14.24±1.30 μM in HepG2 cells.

HY-122521

Sootepin D	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Rubiaceae Gardenia sootepensis hutchins. Plants Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	NF-κB
Sootepin D (compound 6), a triterpene from the apical bud of Gardenia sootepensis, inhibits TNF-α-induced NF-κB activity with an IC₅₀ of 8.3μM. Sootepin D has anti-inflammatory activity .

HY-N7699A

D-Trimannuronic acid	Polysaccharides other families Source classification Plants Saccharides	TNF Receptor
D-Trimannuronic acid, an alginate oligomer is extracted from seaweed. D-Trimannuronic acid can induce TNF‐α secretion by mouse macrophage cell lines. D-Trimannuronic acid can be used for the research of pain and vascular dementia .

HY-N3380

Linderaspirone A	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.	PGE synthase Interleukin Related
Linderaspirone A is a natural compound that can be isolated from the roots of Lindera aggregate. Linderaspirone A shows significant inhibitory effects on the production of prostaglandin E2 (PGE2),TNF-α, and IL-6 .

HY-N11892

7-O-Methylaloesinol	Structural Classification Natural Products Liliaceae Source classification Aloe vera (L.) Burm. f. Plants	NF-κB
7-O-Methylaloesinol is a chromone derivative. 7-O-Methylaloesinol shows significant inhibitory effects against TNFα-induced NF-κB transcriptional activity with an IC₅₀ value of 29.07 μM .

HY-N13184

Giraldoid B	Structural Classification Thymelaeaceae Source classification Daphne giraldii Nitsche Coumarins Phenylpropanoids Plants	TNF Receptor
Giraldoid B is an active ingredient that can be isolated from Girald Daphne Bark. Giraldoid B can inhibit LPS induced NO and b>TNF-α production in RAW264.7 and has anti-inflammatory activity .

HY-138063

Siegeskaurolic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Compositae Tephrosia candida DC.	TNF Receptor NF-κB
Siegeskaurolic acid is an orally active anti-inflammatory agent. Siegeskaurolic acid inhibits the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha) and the activationon of nuclear factor-kappaB .

HY-N12743

Farobin A	Structural Classification Zea mays L. Flavonoids Flavones Gramineae Source classification Plants	Bacterial
Farobin A is a natural compound with antibacterial, antioxidant and anti-inflammatory activities. Farobin A against Streptococcus mutans ATCC 25175 and Streptococcus sobrinus ATCC 33478. Farobin A shows anti-inflammatory activity on cytokine IL-6 and TNF-α .

Cat. No.	Product Name	Chemical Structure

HY-12085S

Apremilast-d5
Apremilast-d₅ is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].

HY-13740S

Resiquimod-d5
Resiquimod-d₅ is deuterium labeled Resiquimod. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α[1][2].

HY-125527S

Resolvin D1-d5

Resolvin D1-d₅ is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].

HY-114360AS1

Taurohyodeoxycholic acid-d4 sodium
Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium) . Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-N8593S

Undecane-d24
Undecane-d₂₄ is the deuterium labeled Undecane[1]. Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[2].

HY-N0803S

Myrcene-d6
Myrcene-d6 is the deuterium labeled Myrcene. Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity .

HY-19717S

DCVC-13C3,15N
DCVC- ¹³C₃, ¹⁵N is ¹⁵N and ¹³C labeled DCVC. DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and *TNF-α* release from tissue cultures .

HY-128423AS

Tylvalosin-d9
Tylvalosin-d₉ (Acetylisovaleryltylo?sin-d₉)is the deuterium labeledTylvalosin(HY-128423A) . Tylvalosin is a third-generation macrolide, with anti-inflammatory property. Tylvalosin decreases the levels of IL-8, IL-6, IL-1β, PGE2, TNF-α and NO, and reduces the inflammatory cells recruitment and activation in mouse acute lung injury model .

HY-N8015S1

Octanal-d2
Octanal-d₂ is deuterated labeled Myrcene (HY-N0803). Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity .

HY-W015879S

2-Heptanol-d5
2-Heptanol-d₅ is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks