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disrupter

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785

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4

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7

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55

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68

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2

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11

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76

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48

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5

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5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W092533
    6-Fluorotryptophan

    		Tryptophan Hydroxylase Neurological Disease
    6-Fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase, produced a transient disruption of sleep in rats chronically implanted with EEG recording electrodes .
    6-Fluorotryptophan
  • HY-131122S
    4-Nonylphenol-D5

    4-n-Nonylphenol-2,3,5,6-d4,OD

    		 Estrogen Receptor/ERR Others
    4-Nonylphenol-d5 is the deuterium labeled 4-Nonylphenol. 4-Nonylphenol, a major degradation product of Nonylphenol ethoxylates (NPEOs), is a persistent organic pollutant with endocrine-disrupting properties and exerts estrogenic activity[1].
    4-Nonylphenol-D5
  • HY-W013935
    Bisphenol B

    		Endogenous Metabolite Endocrinology
    Bisphenol B is a very close structural analog of Bisphenol A (HY-18260), an endocrine disrupting chemical (EDC) and a substance of very high concern (SVHC) in the European Union (EU) for both human health. Bisphenol B shows endocrine disruptive properties or other adverse effects on animal models .
    Bisphenol B
  • HY-111009
    Swinholide A

    		Fungal Infection
    Swinholide A is the actin-binding marine polyketide and dimerizes actin with the Kd of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .
    Swinholide A
  • HY-145061
    ADAMTS-5-IN-3

    		ADAMTS Metabolic Disease Inflammation/Immunology
    ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis .
    ADAMTS-5-IN-3
  • HY-121287
    Ioxynil

    		Herbicide Cardiovascular Disease
    Ioxynil is an herbicide that act as endocrine disruptor. Ioxynil can disrupt vascular and heart development in zebrafish .
    Ioxynil
  • HY-133222
    STX140

    		Estrogen Receptor/ERR Microtubule/Tubulin Apoptosis Cancer
    STX140 is an orally active microtubule disruptor. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell lines. STX140 has anti-angiogenic and anti-tumour activities .
    STX140
  • HY-W013935R
    Bisphenol B (Standard)

    		Endogenous Metabolite Endocrinology
    Bisphenol B (Standard) is the analytical standard of Bisphenol B. This product is intended for research and analytical applications. Bisphenol B is a very close structural analog of Bisphenol A (HY-18260), an endocrine disrupting chemical (EDC) and a substance of very high concern (SVHC) in the European Union (EU) for both human health. Bisphenol B shows endocrine disruptive properties or other adverse effects on animal models .
    Bisphenol B (Standard)
  • HY-N11600
    β-Apopicropodophyllin

    		Apoptosis Cancer
    β-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer .
    β-Apopicropodophyllin
  • HY-145820
    Tubulin inhibitor 14

    		Apoptosis Microtubule/Tubulin Cancer
    Tubulin inhibitor 14 is a potent NQO2 (quinone oxidoreductase 2) inhibitor with an IC50 of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential tumor-selectivity and antiangiogenic and vascular disrupting features .
    Tubulin inhibitor 14
  • HY-B1866
    Linuron

    		Androgen Receptor Endocrinology
    Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive androgen receptor (AR) antagonist with a Ki of 100 μM. Linuron shows reproductive toxicity in animals that acts as an endocrine disruptor .
    Linuron
  • HY-B1066
    Butylhydroxyanisole
    5 Publications Verification

    Butylated hydroxyanisole; BHA; E320

    		 Reactive Oxygen Species Ferroptosis Neurological Disease Inflammation/Immunology
    Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development . Butylhydroxyanisole is a ferroptosis inducer .
    Butylhydroxyanisole
  • HY-B1866R
    Linuron (Standard)

    		Androgen Receptor Endocrinology
    Linuron (Standard) is the analytical standard of Linuron. This product is intended for research and analytical applications. Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive androgen receptor (AR) antagonist with a Ki of 100 μM. Linuron shows reproductive toxicity in animals that acts as an endocrine disruptor .
    Linuron (Standard)
  • HY-162488
    Laccase-IN-3

    		Fungal Infection
    Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS .
    Laccase-IN-3
  • HY-151424
    Vimentin-IN-1

    		Proteasome Cancer
    Vimentin-IN-1 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin (VIM), to induce hyperphosphorylation of Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Vimentin-IN-1 shows better oral bioavailability and pharmacokinetic profiles than FiVe1 .
    Vimentin-IN-1
  • HY-17587
    4-Methylbenzylidene camphor
    1 Publications Verification

    4-MBC; Enzacamene

    		 Apoptosis PI3K Akt ERK Metabolic Disease
    4-Methylbenzylidene camphor (4-MBC) is an endocrine disrupter that produces estrogen-like effects. 4-Methylbenzylidene camphor decreases the proliferation of human trophoblast cells and induces apoptosis. 4-Methylbenzylidene camphor activates PI3K/AKT and ERK1/2 signaling pathways and elevates intracellular ROS production. 4-Methylbenzylidene camphor is a ultraviolet (UV) filter and may hamper normal placental formation during early pregnancy .
    4-Methylbenzylidene camphor
  • HY-17587R
    4-Methylbenzylidene camphor (Standard)

    		Apoptosis PI3K Akt ERK Metabolic Disease
    4-Methylbenzylidene camphor (Standard) is the analytical standard of 4-Methylbenzylidene camphor. This product is intended for research and analytical applications. 4-Methylbenzylidene camphor (4-MBC) is an endocrine disrupter that produces estrogen-like effects. 4-Methylbenzylidene camphor decreases the proliferation of human trophoblast cells and induces apoptosis. 4-Methylbenzylidene camphor activates PI3K/AKT and ERK1/2 signaling pathways and elevates intracellular ROS production. 4-Methylbenzylidene camphor is a ultraviolet (UV) filter and may hamper normal placental formation during early pregnancy .
    4-Methylbenzylidene camphor (Standard)
  • HY-118555
    Vascular disrupting agent 1

    		Drug Derivative Others
    Vascular disrupting agent 1 is an active compound.
    Vascular disrupting agent 1
  • HY-14919
    Denibulin

    MN-029 free base

    		 Microtubule/Tubulin Cancer
    Denibulin, a novel vascular-disrupting agent, inhibits microtubule assembly reversibly, disrupting tumor vascular endothelial cell cytoskeletons. Denibulin demonstrated tolerability and potential anti-vascular effects, warranting further investigation in cancer therapy .
    Denibulin
  • HY-108801A
    Aflibercept (VEGF Trap)

    		VEGFR Cardiovascular Disease Metabolic Disease Cancer
    Aflibercept (VEGF Trap) is a soluble decoy VEGFR constructed by fusing the Ig domains of VEGFR1 and VEGFR2 with the Fc region of human IgG1. Aflibercept inhibits VEGF signaling by reducing VEGF-regulated processes. Aflibercept can be used for thr research of age-related macular degeneration (AMD) and cardiovascular disease .
    Aflibercept (VEGF Trap)
  • HY-108801
    Aflibercept

    VEGF Trap; VEGF-TRAPR1R2; VEGF-trapR1

    		 VEGFR Cardiovascular Disease Metabolic Disease Cancer
    Aflibercept (VEGF Trap) is a soluble decoy VEGFR constructed by fusing the Ig domains of VEGFR1 and VEGFR2 with the Fc region of human IgG1. Aflibercept inhibits VEGF signaling by reducing VEGF-regulated processes. Aflibercept can be used for thr research of age-related macular degeneration (AMD) and cardiovascular disease .
    Aflibercept
  • HY-139704
    Eroonazole

    		Biochemical Assay Reagents Others
    Eroonazole is a new small molecule disrupter of endoplasmic reticulum structure.
    Eroonazole
  • HY-P2261
    STAD 2

    		PKA Infection
    STAD 2 is a potent and selective disruptor of PKA-RII, with a Kd of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism .
    STAD 2
  • HY-114982
    KEA1-97

    		Caspase Apoptosis Cancer
    KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity .
    KEA1-97
  • HY-P10907
    Zaloganan

    		Bacterial Infection
    Zaloganan exhibits board-spectrum antibacterial activity through disruption of bacterial membranes .
    Zaloganan
  • HY-16114
    BNC105
    1 Publications Verification

    		 Microtubule/Tubulin Cancer
    BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
    BNC105
  • HY-101295
    Pan-RAS-IN-1
    5+ Cited Publications

    		 Ras Cancer
    Pan-RAS-IN-1 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors.
    Pan-RAS-IN-1
  • HY-B2058
    Triticonazole

    		Fungal Infection
    Triticonazole is a triazole pesticide. Triticonazole is an azole fungicide and shows endocrine disrupting activities .
    Triticonazole
  • HY-136861
    Antibacterial agent 192

    		Bacterial Infection
    Antibacterial agent 192 is an antibacterial agent that can disrupt iron homeostasis in E. coli .
    Antibacterial agent 192
  • HY-W013429
    4-Glycidyloxycarbazole

    		Bacterial Infection
    4-Glycidyloxycarbazole (compound 8) is an antimicrobial agent that disrupts bacterial biofilm formation .
    4-Glycidyloxycarbazole
  • HY-138294
    RAS/RAS-RAF-IN-1
    1 Publications Verification

    		 Ras Raf Cancer
    RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μΜ-15 μΜ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity .
    RAS/RAS-RAF-IN-1
  • HY-15579AS
    MMAF-d8 hydrochloride
    1 Publications Verification

    		 Microtubule/Tubulin ADC Cytotoxin Cancer
    MMAF-d8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
    MMAF-d8 hydrochloride
  • HY-132930
    TCMDC-136230

    		Parasite Infection
    TCMDC-136230 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.
    TCMDC-136230
  • HY-15581S
    MMAD-d8

    Demethyldolastatin 10-d8; Monomethylauristatin D-d8; Monomethyl Dolastatin 10-d8

    		 ADC Cytotoxin Microtubule/Tubulin Cancer
    MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.
    MMAD-d8
  • HY-132929
    TCMDC-125431

    		Parasite Infection
    TCMDC-125431 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.
    TCMDC-125431
  • HY-12411
    AMG-3969
    1 Publications Verification

    		 Glucokinase Metabolic Disease
    AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM.
    AMG-3969
  • HY-A0067
    Oxybenzone
    1 Publications Verification

    Benzophenone 3

    		 RAR/RXR Autophagy Apoptosis Neurological Disease
    Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
    Oxybenzone
  • HY-N12612
    CNP0296775

    		DNA Methyltransferase Dengue Virus Infection
    CNP0296775 is an inhibitor of dengue virus methyltransferase (DENV MTase) that has the potential to disrupt the viral replication process .
    CNP0296775
  • HY-122683
    sAJM589
    1 Publications Verification

    		 c-Myc Cancer
    sAJM589 is a Myc inhibitor which potently disrupts the Myc-Max heterodimer with an IC50 of 1.8 μM .
    sAJM589
  • HY-19560
    SBI-0640756
    2 Publications Verification

    SBI-756

    		 Eukaryotic Initiation Factor (eIF) Autophagy Cancer
    SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex.
    SBI-0640756
  • HY-157417
    G-quadruplex ligand 1

    		DNA/RNA Synthesis Others
    G-quadruplex ligand 1, a G-quadruplex ligand, disrupts G-Quadruplex DNA structure and enhances gene expression .
    G-quadruplex ligand 1
  • HY-B0827
    Dinotefuran
    3 Publications Verification

    MTI-446

    		 nAChR Parasite Infection
    Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors.
    Dinotefuran
  • HY-W042284
    Tetradecyl acetate

    Myristyl acetate

    		 Herbicide Metabolic Disease
    Tetradecyl acetate is a sex pheromone produced by Ctenopseustis obliquana females. Tetradecyl acetate can be used to disrupt the mating of pest species .
    Tetradecyl acetate
  • HY-151567
    Antibacterial agent 123

    		Bacterial Infection
    Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria .
    Antibacterial agent 123
  • HY-163073
    Anti-MRSA agent 9

    		Bacterial Infection
    Anti-MRSA agent 9 (compound 39) shows antibacterial effects against clinically isolated methicillin-resistant Staphylococcus aureus (MRSA) with MIC values of 1 μg/ml. Anti-MRSA agent 9 also shows anti-MRSA efficacy in vivo .
    Anti-MRSA agent 9
  • HY-18256
    Ombrabulin hydrochloride

    AVE8062 hydrochloride; AC7700 hydrochloride

    		 Microtubule/Tubulin Cardiovascular Disease Cancer
    Ombrabulin hydrochloride is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
    Ombrabulin hydrochloride
  • HY-16036A
    ALB-109564 hydrochloride

    12'-Methylthiovinblastine hydrochloride

    		 Microtubule/Tubulin Cancer
    ALB-109564 (12'-Methylthiovinblastine) hydrochloride, a tubulin inhibitor, is a cytotoxic agent designed to kill cancer cells by disrupting mitosis .
    ALB-109564 hydrochloride
  • HY-169219
    DK06

    		Bacterial Cancer
    DK06 (compund DK06) inhibits the growth of Listeria monocytogenes, disrupts biofilm formation and reduces extracellular polymeric substances .
    DK06
  • HY-N1408
    trans-Trimethoxyresveratrol

    trans-trismethoxy Resveratrol; E-Resveratrol Trimethyl Ether; Tri-O-methylresveratrol

    		 Reactive Oxygen Species Inflammation/Immunology Cancer
    Trans-Trimethoxyresveratrol is a derivative of Resveratrol (RSV),and it may be a more potent anti-inflammatory, antiangiogenic and vascular-disrupting agent when compared with resveratrol.
    trans-Trimethoxyresveratrol
  • HY-N5142S
    α-Terpineol-d3

    		Bacterial Infection
    α-Terpineol-d3 is the deuterium labeled α-Terpineol[1]. α-Terpineol is isolated from Eucalyptus globulus Labill, exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria[2].α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption[2].
    α-Terpineol-d3

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