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Results for "

anti-cancer agents

" in MedChemExpress (MCE) Product Catalog:

By Targets:	BCRP (1) 5-HT Receptor (3) ADC Cytotoxin (21) Adenosine Deaminase (1) Adrenergic Receptor (6) Akt (8) Amino Acid Derivatives (2) AMPK (7) Amyloid-β (4) Androgen Receptor (1) Antibiotic (30) Antibody-Drug Conjugates (ADCs) (1) Antifolate (2) Apoptosis (251) Arrestin (2) Aryl Hydrocarbon Receptor (1) Atg4 (1) ATM/ATR (1) Autophagy (68) Bacterial (53) Bcl-2 Family (22) BCL6 (1) Bcr-Abl (1) Biochemical Assay Reagents (33) BMI1 (1) c-Fms (1) c-Kit (1) c-Met/HGFR (1) c-Myc (4) Calcium Channel (9) Calmodulin (1) CaMK (5) Carbonic Anhydrase (1) Caspase (24) Cathepsin (1) CDK (16) Checkpoint Kinase (Chk) (2) ClpP (1) CMV (2) COX (10) CXCR (2) Cytochrome P450 (15) Dihydrofolate reductase (DHFR) (1) DNA Alkylator/Crosslinker (18) DNA Stain (1) DNA-PK (1) DNA/RNA Synthesis (41) Dopamine Receptor (8) Drug Derivative (34) Drug Intermediate (4) Drug Isomer (1) Drug Metabolite (4) Drug-Linker Conjugates for ADC (3) E1/E2/E3 Enzyme (4) EGFR (8) Endogenous Metabolite (32) ERK (5) FAK (1) Ferroptosis (19) FLT3 (4) Fluorescent Dye (1) FOXO (1) Fungal (39) G-quadruplex (1) Glutathione S-transferase (1) Glyoxalase (GLO) (4) GnRH Receptor (1) GSK-3 (4) HBV (5) HDAC (5) Hedgehog (4) HIF/HIF Prolyl-Hydroxylase (2) Histamine Receptor (2) Histone Acetyltransferase (1) Histone Methyltransferase (2) HIV (10) HIV Protease (5) HMG-CoA Reductase (HMGCR) (3) HSP (3) HSV (5) IAP (3) IGF-1R (1) Influenza Virus (13) Insulin Receptor (1) Integrin (2) Interleukin Related (2) Isotope-Labeled Compounds (22) JAK (5) JNK (3) Kinesin (3) Lactate Dehydrogenase (2) LDLR (1) Liposome (5) MAPKAPK2 (MK2) (1) MDM-2/p53 (12) MEK (1) MetAP (1) Microtubule/Tubulin (29) Mitochondrial Metabolism (10) Mitophagy (14) Mixed Lineage Kinase (1) MMP (8) Molecular Glues (3) Monocarboxylate Transporter (1) mTOR (3) Na+/K+ ATPase (2) NAMPT (1) Necroptosis (7) NEKs (1) NF-κB (12) NO Synthase (1) Nuclear Factor of activated T Cells (NFAT) (1) Nuclear Hormone Receptor 4A/NR4A (2) Nucleoside Antimetabolite/Analog (6) Orphan Receptor (1) Orthopoxvirus (8) P-glycoprotein (16) p38 MAPK (8) Paraptosis (2) Parasite (21) PARP (15) PDGFR (1) Penicillin-binding protein (PBP) (1) Peptide-Drug Conjugates (PDCs) (2) Phosphatase (4) Phosphodiesterase (PDE) (1) Phospholipase (1) Photosensitizer (1) PI3K (9) PKC (2) PKD (1) Polo-like Kinase (PLK) (3) Potassium Channel (2) PPAR (2) PROTAC Linkers (3) PROTACs (2) Protease Activated Receptor (PAR) (1) Proteasome (10) PSMA (1) Pyroptosis (2) Pyruvate Kinase (1) Raf (2) RAR/RXR (2) Ras (5) Reactive Oxygen Species (43) RET (1) RIP kinase (1) ROS Kinase (3) SARS-CoV (12) Ser/Thr Kinase (1) Ser/Thr Protease (3) Sirtuin (1) SOD (1) Sodium Channel (2) Src (3) STAT (12) Stearoyl-CoA Desaturase (SCD) (1) Syk (2) TAM Receptor (1) Taste Receptor (1) Telomerase (1) TGF-beta/Smad (3) TGF-β Receptor (1) Thymidylate Synthase (2) TNF Receptor (4) Toll-like Receptor (TLR) (3) Topoisomerase (42) TrxR (1) Tyrosinase (1) VEGFR (3) Virus Protease (1) WDR5 (1) Wee1 (1) Wnt (3) YAP (1) α-synuclein (1)
By Research Areas:	Cancer (779) Cardiovascular Disease (23) Endocrinology (5) Infection (110) Inflammation/Immunology (56) Metabolic Disease (27) Neurological Disease (58)
Click Chemistry:	Azide (1) Alkynes (3)
Oligonucleotides:	Fluorescent Lipids (1) Nucleosides and their Analogs (2) Nucleoside Phosphoramidites (1) Pegylated Lipids (2) Polymers (7) Cholesterol (1)

807

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

147

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: BCRP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7669

Taccalonolide C	Others	Cancer
Taccalonolides C is an anti-cancer agent .

HY-114002

Anticancer agent 129	Drug Derivative	Cancer
Anticancer agent 129 (Compound 3a), a quinoline derivative, predicting to has anti-cancer activity .

HY-W092549

5-Hydroxyisatin	Drug Intermediate	Cancer
5-Hydroxyisatin can be used to synthesize anti-cancer agents .

HY-130071

Iproplatin CHIP	Biochemical Assay Reagents	Cardiovascular Disease Metabolic Disease Cancer
Iproplatin (CHIP) is an anti-cancer agent with reduced toxicity in testicular and ovarian cancers. The major reduced product of Iproplatin by glutathione is chloro-bis (isopropylamine) glutathionatoplatinum (II). Iproplatin is promising for research of Thrombocytopenia and a wide range of cancers .

HY-128689

Anticancer agent 3	Others	Cancer
Anticancer agent 3 (Compound 4) is a anti-cancer agent .

HY-149215

Anticancer agent 101	Others	Cancer
Anticancer agent 101 is a derivative of tetracaine. Anticancer agent 101 has anti-cancer activity .

HY-149062

Anticancer agent 102	Apoptosis	Cancer
Anticancer agent 102 is a derivative of tetracaine. Anticancer agent 102 has anti-cancer activity. Anticancer agent 102 induces apoptosis .

HY-154799

Anticancer agent 112	Others	Cancer
Anticancer agent 112 is a potent *anti-cancer* agent for cancer research, extracted from patent WO2020198567 .

HY-19188

GL-331	Apoptosis	Cancer
GL-331 is a potent anti-cancer agent. GL-331 has demonstrated more efficacious anti-cancer activity in both the in vitro and in vivo lymphoma systems .

HY-149214

Anticancer agent 100	Others	Cancer
Anticancer agent 100 is a derivative of tetracaine with anti-cancer activity and can be used in cancer research .

HY-156187

Anticancer agent 161	Autophagy Mitochondrial Metabolism	Cancer
Anticancer agent 161 (Compound 3b) is a bioactive alkynol with anti-cancer potential. Anticancer agent 161 can trigger autophagy and mitochondrial membrane potential depletion .

HY-162900

HSP90-IN-32	HSP	Cancer
HSP90-IN-32 is a Hsp90 C-terminal inhibitor that displays anti-proliferative activities against SKMel173, SKMel103, SKMel19 and A375 cells with IC₅₀ values of 1.01 μM, 0.782 μM, 0.607 μM and 1.413 μM , respectively. HSP90-IN-32 is promising for research of anti-cancer agents .

HY-147782

Anticancer agent 67	Apoptosis	Cancer
Anticancer agent 67 (Compound 13g) is an anti-cancer agent. Anticancer agent 67 induces apoptosis and increases sub-G1 cell population in MCF-7 cells. Anticancer agent 67 is a ciprofloxacin analog .

HY-147781

Anticancer agent 66	Apoptosis	Cancer
Anticancer agent 66 (Compound 13e) is an anti-cancer agent. Anticancer agent 66 induces apoptosis and increases sub-G1 cell population in MCF-7 cells. Anticancer agent 66 is a ciprofloxacin analog .

HY-153757

Antioxidant agent-11	Others	Cancer
Antioxidant agent-11 (compound 3d) is a compound that has weak anti-cancer and antioxidant activities .

HY-147783

Anticancer agent 68	MDM-2/p53	Cancer
Anticancer agent 68 is (Compound 12) is an anti-cancer agent. Anticancer agent 68 arrests the cells at the G2/M phase and induces programmed cell death. Anticancer agent 68 induces upregulation of tumor suppression via activation of p53 & PTEN .

HY-117457

BPIC	DNA/RNA Synthesis	Cancer
BPIC is a DNA intercalator agent and also an anti-cancer agent. BPIC scavenge ∙OH, ∙O2(-), and NO free radicals .

HY-111761

DIQ3	Drug Derivative	Cancer
DIQ3 is a potent anti-cancer agent, nontoxic to normal human cell lines .

HY-13741

RH1 1 Publications Verification NSC 697726	Apoptosis	Cancer
RH1 (NSC 697726) is a potent bioreductive agent with profound anti-cancer activity in vitro and in vivo.

HY-149344

Anticancer agent 133	Apoptosis Autophagy EGFR	Cancer
Anticancer agent 133 (compound Rh2) is an anti-cancer agent with cytotoxic and antimetastatic activities. Anticancer agent 133 induces cell cycle arrest, apoptosis, and autophagy. Anticancer agent 133 also inhibits cell metastasis via suppression of EGFR expression mediated by FAK-regulated integrin β1 .

HY-N9358

Argentinogenin	Others	Cancer
Argentinogenin is a natural compound with anti-cancer activity that could be found in traditional Chinese agent Chan Su .

HY-N9437

Betulin diacetate Betulin 3,28-diacetate	HIV	Infection Inflammation/Immunology Cancer
Betulin diacetate, a triterpene and derivative of Betulin, is an anti-AID agent and also possesses anti-cancer activity .

HY-116543

ST362	Apoptosis	Cancer
ST362 is a anti-cancer agent. ST362 induces cell apoptosis and inhibits cancer cell growth .

HY-15866

FR901465	Others	Cancer
FR901465 is a potent *anti-cancer* and anti-tumor agent. FR901465 can be used for cancer research .

HY-147776

Antiproliferative agent-8	MDM-2/p53	Cancer
Antiproliferative agent-8 (Compound 5a) is an anti-cancer agent. Antiproliferative against-8 has antiproliferative activity. Antiproliferative agent-8 significantly increases the P53 levels .

HY-141478

Antitumor agent-28	ATM/ATR	Cancer
Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity .

HY-162276

Anticancer agent 188	Reactive Oxygen Species DNA/RNA Synthesis	Cancer
Anticancer agent 188 (compound D43) inhibits DNA synthesis in TNBC cells, leading to cell cycle arrest at the G2/M phase. Anticancer agent 188 has anti-cancer viability by inducing ROS-mediated apoptosis and DNA damage .

HY-30236

5-Bromoindole	Drug Intermediate	Cancer
5-Bromoindole is a chemical intermediate that can be used for the synthesis of GSK-3 inhibitors and anti-cancer agents .

HY-W548095

Anticancer agent 170	Drug Derivative	Cancer
Anticancer agent 170 (compound 3a) is a keton derivative of Deguelin (HY-13425), and shows potency anti-cancer activity against A549, with the IC₅₀ of 6.62 μM .

HY-N10782

Balanophonin	Apoptosis COX TNF Receptor p38 MAPK	Neurological Disease Inflammation/Immunology Cancer
Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis .

HY-106541

Neticonazole	Fungal	Infection Cancer
Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects .

HY-12538

Graveoline Rutamine	Apoptosis Autophagy Fungal	Infection Cancer
Graveoline (Rutamine) is an anti-cancer agent that can trigger apoptosis and autophagy in skin melanoma cells. Graveoline also exhibits antifungal activity .

HY-128365

Neticonazole hydrochloride	Fungal	Infection Cancer
Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride has anti-infection and anti-cancer effects .

HY-12352A

HJC0416 hydrochloride 1 Publications Verification	STAT Apoptosis	Cancer
HJC0416 hydrochloride is a potent and orally active STAT3 inhibitor with an enhanced anticancer profile than Stattic (HY-13818). HJC0416 hydrochloride is a promising anti-cancer agent for breast cancer study .

HY-N12473

25-Deacetylcucurbitacin A	JAK	Inflammation/Immunology
25-Deacetylcucurbitacin A is a Cucurbitane-Type triterpenoid and has the potential to be an *anti-cancer* agent and JAK/STAT3 signaling pathway inhibitor .

HY-146444

Anticancer agent 56	Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species	Cancer
Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with agent-likeness properties, possessing anticancer activity against several cancer cell lines (IC₅₀<3 μM). Anticancer agent 56 induces cell cycle arrest at G2/M phase and triggers mitochondrial apoptosis pathway. Anticancer agent 56 acts by accumulation of ROS, up regulation of BAX, down regulation of Bcl-2 and activation of caspases 3, 7, 9 .

HY-113462

α-Carotene	Others	Cancer
α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer agents. α-Carotene is isolated from yellow-orange and dark-green vegetables .

HY-43058

5'-O-DMT-ibu-rG 5'-O-DMT-N2-isobutyrylguanosine	Nucleoside Antimetabolite/Analog	Others Cancer
5'-O-DMT-ibu-rG is a useful model for a new class of DNA binding molecules for the development of potent and selective anti-cancer agents .

HY-111621

DC661 4 Publications Verification	Autophagy Apoptosis	Cancer
DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity .

HY-162348

Antitumor agent-145	Necroptosis	Cancer
Antitumor agent-145 (Compound Ir5) is a tumor inhibitor with remarkable fluorescence and mitochondrial targeting, which exerts anti-cancer effects by inducing necroptosis and activating the necroptosis-related immune response .

HY-155251

anti-TNBC agent-3	Apoptosis Bcl-2 Family	Cancer
anti-TNBC agent-3 (compound 3g) is an apoptosis inducer with anti-cancer cell proliferation activity. anti-TNBC agent-3 inhibits tumor growth and metastasis in triple-negative breast cancer (TNBC) xenograft models .

HY-152099

Antiproliferative agent-19	Apoptosis	Cancer
Antiproliferative agent-19 (compound 4a) is an **anti-cancer agent** that exerts anti-proliferative effects on lung cancer cells by inducing apoptosis. antiproliferative agent-19 also induces cell cycle arrest in the G2/M phase .

HY-15865

FR901463	DNA/RNA Synthesis	Cancer
FR901463 is a potent **anti-cancer agent** and can be used for cancer research. FR901463 enhances the transcriptional activity of the promoter of SV40 DNA virus .

HY-13748

Silybin A 5+ Cited Publications Silibinin A	Autophagy Reactive Oxygen Species	Cancer
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

HY-136552

β-Bisabolene	Others	Cancer
β-Bisabolene is a sesquiterpene isolated from opoponax (Commiphora guidotti). β-Bisabolene, an **anti-cancer agent*, can be used for the study of breast cancer* .

HY-156675

Plecstatin-1	Others	Cancer
Plecstatin-1 is a potent organoruthenium *anti-cancer* agent . Plecstatin-1 selectively targets plectin (a scaffold protein and cytolinker) in tumour spheroids .

HY-15044

NU1025	PARP	Neurological Disease Cancer
NU1025 is a potent PARP inhibitor with an IC₅₀ of 400 nM and a K_i of 48 nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer agents. NU1025 has anti-cancer and neuroprotective activity .

HY-122944

20-Deoxocarnosol	Others	Cancer
20-Deoxocarnosol (compound 7) is a potent *anti-cancer* agent that can be found in the roots of Salvia deserta. 20-Deoxocarnosol shows cytotoxicity in cancer cells .

HY-114243

DpC	Others	Cancer
DpC is an anti-tumor agent. DpC inhibits cancer cell proliferation (IC₅₀: 0.007-0.096 μM). DpC synergizes with multiple anti-cancer therapeutics .

HY-111343

ONC212 4 Publications Verification	Apoptosis	Endocrinology Cancer
ONC212, a fluorinated-ONC201 analogue, is a promising anti-cancer agent and also a selective agonist of GPR132. ONC212 also induces apoptosis .

Cat. No.	Product Name

HY-L155

Mitochondrial Toxicity Compound Library

505 compounds

Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity.

MCE contains 505 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.

HY-L076

Drug-Induced Liver Injury (DILI) Compound Library

1,459 compounds

Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug.

DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver.

MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 1,459 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.

HY-L067

Antibiotics Library

743 compounds

Antibiotics are types of antimicrobial products used for the treatment and prevention of bacterial infections. Antibiotics can kill or inhibit bacterial growth. Although the target of an antibiotic is bacteria, some antibiotics also attack fungi and protozoans. However, antibiotics rarely have an effect on viruses. The major mechanism underlying antibiotics is the inhibition or regulation of enzymes involved in cell wall biosynthesis, nucleic acid metabolism and repair, protein synthesis, or disruption of membrane structure. Many of these cellular functions targeted by antibiotics are most active in multiplying cells. Since there is often overlap in these functions between prokaryotic bacterial cells and eukaryotic mammalian cells, it is not surprising that some antibiotics have also been found to be useful as anticancer agents.

MCE supplies a unique collection of 743 antibiotics, including penicillins, cephalosporins, tetracyclines, macrolides, etc. MCE Antibiotics Library is a useful tool for anti-bacterial or anti-cancer drugs discovery.

HY-L058

Glycolysis Compound Library

888 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 888 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

HY-L213

Anti-Cancer Approved Drug Library

283 compounds

The anti-cancer drug library meticulously collects all drugs approved by FDA and other major national drug regulatory authorities for cancer treatment. These drugs cover a variety of cancer types, including but not limited to lung cancer, breast cancer, colorectal cancer, leukemia, and other common cancers. The library includes a wide range of drugs, from classic chemotherapeutic agents to cutting-edge targeted therapies and immunotherapies. It contains various types of drug compounds with different mechanisms of action. There are cytotoxic drugs that directly kill cancer cells, as well as drugs that work by modulating the tumor microenvironment, inhibiting tumor angiogenesis, and activating the immune system. This diversity provides researchers with a broad range of perspectives and options for intervention strategies.

This library can be used for basic research on cancer treatment, exploring new targets and new mechanisms of drug action; Conducting drug reuse research to look for potential therapeutic effects of existing drugs on other cancer types or diseases; Or conducting research into combination drugs to optimize cancer treatment.

MCE has collected 283 small-molecule compounds with cancer indications, which are good tools for drug repurposing.

HY-L065

Traditional Chinese Medicine Active Compound Library

2,953 compounds

Chinese herbal therapy is an important part of Traditional Chinese Medicine (TCM). It has been used for centuries in China, where herbs are considered fundamental therapy for many acute and chronic conditions. Many studies indicated TCM exerted an overall regulatory effect via multi-component and multi-target network. Active components from Traditional Chinese Medicine possess many medicinal properties such as antioxidant, anti-cancer, and anti-bacterial effects, which makes it an important source of new drugs. Nearly 200 modern medicines have been developed either directly or indirectly from the plants used as medicines in China. For example, artemisinin, used in multidrug resistant malaria, was first isolated from the Chinese herb Artemisia annua L. Today, scientists continue to identify compounds in Chinese herbal remedies that may be useful in the development of new therapeutic agents applicable in Western medicine.

MCE designs a unique collection of 2,953 active compounds of Chinese Herbal Medicines. MCE Traditional Chinese Medicine Active Compound Library is a useful tool for discovery new drugs from TCM.

HY-L143

Marine-Sourced Natural Product Library

55 compounds

Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria.

Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union.

MCE offers a unique collection of 55 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Cat. No.	Product Name	Type

HY-B0166GL

L-Ascorbic acid (GMP Like)

L-Ascorbate (GMP Like); Vitamin C (GMP Like)

Fluorescent Dye

L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid (HY-B0166). L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-P1004

Luciferase	Fluorescent Dyes/Probes
Luciferase is an enzyme that catalyzes the oxidation of the substrate luciferin and produces bioluminescence. Luciferase can reflect the content of related substances by detecting the intensity of the light signal. Luciferase can monitor the growth and metastasis of cancer cells and evaluate the efficacy of anticancer agents .

HY-D0226

Quinizarin 1,4-Dihydroxyanthraquinone	Fluorescent Dyes/Probes
Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (K_d=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth .

HY-B0166GLR

L-Ascorbic acid (GMP Like) (Standard)

Fluorescent Dye

L-Ascorbic acid (GMP Like) (Standard) is the analytical standard of L-Ascorbic acid (GMP Like). This product is intended for research and analytical applications. L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid (HY-B0166). L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-D0226R

Quinizarin (Standard)

Fluorescent Dyes/Probes

Quinizarin (Standard) is the analytical standard of Quinizarin. This product is intended for research and analytical applications. Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth .

Cat. No.	Product Name	Type

HY-B0166GL

L-Ascorbic acid (GMP Like)

L-Ascorbate (GMP Like); Vitamin C (GMP Like)

Biochemical Assay Reagents

HY-148702

di-Pal-MTO	Drug Delivery
di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity .

HY-155882

mPEG-amine (MW 750) mPEG-NH2 (MW 750)	Drug Delivery
mPEG-amine (MW 750) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-B0166GLR

L-Ascorbic acid (GMP Like) (Standard)

Biochemical Assay Reagents

HY-172351

PEG-bis-amine (MW 400)	Drug Delivery
PEG-bis-amine (MW 400) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent Rubitecan (HY-16560) .

HY-172351A

PEG-bis-amine (MW 6000)	Drug Delivery
PEG-bis-amine (MW 6000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent Rubitecan (HY-16560) .

HY-172351B

PEG-bis-amine (MW 10000)	Drug Delivery
PEG-bis-amine (MW 10000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent Rubitecan (HY-16560) .

HY-148701

mono-Pal-MTO	Drug Delivery
mono-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity .

HY-155880

mPEG-amine (MW 350) mPEG-NH2 (MW 350)	Drug Delivery
mPEG-amine (MW 350) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155883

mPEG-amine (MW 3400) mPEG-NH2 (MW 3400)	Drug Delivery
mPEG-amine (MW 3400) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155881

mPEG-amine (MW 550) mPEG-NH2 (MW 550)	Drug Delivery
mPEG-amine (MW 550) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155884

mPEG-amine (MW 4000) mPEG-NH2 (MW 4000)	Drug Delivery
mPEG-amine (MW 4000) can be used to synthesize folate-conjugated polymer micelles for encapsulating anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-125924

DSPE-PEG-Amine, MW 2000 ammonium 1 Publications Verification DSPE-PEG-NH2, MW 2000 ammonium; DSPE-PEG(2000) Amine ammonium	Drug Delivery
DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents .

HY-W115607

PEG-bis-amine (MW 8000) Poly(ethylene glycol)-bis-amine (MW 8000)	Drug Delivery
PEG-bis-amine (MW 8000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-W591632

PEG-bis-amine (MW 1000) Poly(ethylene glycol)-bis-amine (MW 1000)	Drug Delivery
PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-W054292

tert-Butyl-DCL (OtBu)KuE(OtBu)2	Biochemical Assay Reagents
tert-Butyl-DCL is a small molecule PSMAM inhibitor with anticancer activity that targets prostate-specific membrane antigen (PSMA). tert-Butyl-DCL is also an effective bioimaging agent that has high selectivity and affinity, allowing it to target and highlight specific receptors on the surface of tumor cells .

HY-W440919

DSPE-PEG-Rhodamine, MW 2000	Drug Delivery
DSPE-PEG-Rhodamine, MW 2000 is a dye functionalized phospholipid. The amphiphilic polymer can form lipid bilayer in water and be used to encapsulate therapeutic agents, such as liposomal anticancer drug or mRNA vaccine. Rhodamine has maximum absorption at 570 nm and emission around 595 nm and can be easily traced using an imaging technique.

HY-140696C

m-PEG-OH (MW 20000)

mPEG-Hydroxy (MW 20000); Polyethylene glycol monomethyl ether (MW 20000)

Drug Delivery

m-PEG-OH (MW 20000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Nanoscale micelles can be prepared by using amphiphilic block copolymers to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger activity in killing cancer cells than free Paclitaxel. And it preferentially accumulates in tumor tissue with only limited distribution in healthy organs.

HY-140696D

m-PEG-OH (MW 10000)

mPEG-Hydroxy (MW 10000); Polyethylene glycol monomethyl ether (MW 10000)

Drug Delivery

m-PEG-OH (MW 10000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger activity in killing cancer cells than free Paclitaxel. And it preferentially accumulates in tumor tissue with only limited distribution in healthy organs.

HY-140696E

m-PEG-OH (MW 1000)

mPEG-Hydroxy (MW 1000); Polyethylene glycol monomethyl ether (MW 1000)

Drug Delivery

m-PEG-OH (MW 1000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger cancer-killing activity than free Paclitaxel. And it accumulates preferentially in tumor tissues and has only limited distribution in healthy organs.

HY-P2232

Conalbumin

Ovotransferrin

Native Proteins

Conalbumin (Ovotransferrin), also known as ovotransferrin, is a monomeric glycoprotein consisting of 686 amino acids, encoded by the avian transferrin gene in the oviduct, and a prominent component of chicken egg white. Exhibiting a unique glycosylation pattern that differentiates it from serum transferrin, Conalbumin is a potent iron binder that plays a crucial role in iron transport to developing embryos. Additionally, it possesses a range of biological activities, including antimicrobial, antifungal, antiviral, anticancer, antioxidative, antihypertensive, and immunoregulatory properties, making it valuable in numerous applications such as infant formula ingredients, food additives, and agents for enhancing animal health.

HY-W027592

1H-1,2,4-Triazol-3-amine

Cell Assay Reagents

1H-1,2,4-Triazol-3-amine consists of a triazole ring system and an amino group attached to carbon atom 3. The compound has potential applications in various fields such as medicinal chemistry, agrochemicals and material science. In medicinal chemistry, 1H-1,2,4-Triazol-3-amine is used as a starting material for the synthesis of pharmaceutical compounds such as antifungal agents, anticancer agents, and enzyme inhibitors associated with cardiovascular disease. In agrochemicals, it can be used as a raw material for the synthesis of herbicides, fungicides and insecticides. Furthermore, 1H-1,2,4-Triazol-3-amine is used as a ligand in coordination chemistry and as a precursor for the production of new functional materials such as polymers and metal-organic frameworks.

HY-W027592R

1H-1,2,4-Triazol-3-amine (Standard)

Cell Assay Reagents

1H-1,2,4-Triazol-3-amine (Standard) is the analytical standard of 1H-1,2,4-Triazol-3-amine. This product is intended for research and analytical applications. 1H-1,2,4-Triazol-3-amine consists of a triazole ring system and an amino group attached to carbon atom 3. The compound has potential applications in various fields such as medicinal chemistry, agrochemicals and material science. In medicinal chemistry, 1H-1,2,4-Triazol-3-amine is used as a starting material for the synthesis of pharmaceutical compounds such as antifungal agents, anticancer agents, and enzyme inhibitors associated with cardiovascular disease. In agrochemicals, it can be used as a raw material for the synthesis of herbicides, fungicides and insecticides. Furthermore, 1H-1,2,4-Triazol-3-amine is used as a ligand in coordination chemistry and as a precursor for the production of new functional materials such as polymers and metal-organic frameworks.

Cat. No.	Product Name	Target	Research Area

HY-113064

Selenocystine 1 Publications Verification	Endogenous Metabolite	Cancer
Selenocystine is a broad-spectrum *anti-cancer* agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-16050

Plitidepsin 3 Publications Verification Aplidine; PM90001	DNA/RNA Synthesis SARS-CoV	Infection Cancer
Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K_D=80 nM) . Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC₉₀ of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research .

HY-W005308

N-BOC-DL-serine methyl ester	Amino Acid Derivatives	Cancer
N-BOC-DL-serine methyl ester is a Serine derivative. N-BOC-DL-serine methyl ester is used for the synthesis of α,β-dehydro-α-amino acid. N-BOC-DL-serine methyl ester is also used for the synthesis of anti-cancer agent, such as quinazolinone derivative that inhibits PI3K activity, and tricyclic pyrolopyranopyridines that inhibits protein kinase activity .

HY-P1682A

Balixafortide TFA 1 Publications Verification POL6326 TFA	CXCR Arrestin	Cancer
Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

HY-P2341

Angiopep-2 hydrochloride 2 Publications Verification	LDLR	Cancer
Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer .

HY-16050R

Plitidepsin (Standard)	DNA/RNA Synthesis SARS-CoV	Infection Cancer
Plitidepsin (Standard) is the analytical standard of Plitidepsin. This product is intended for research and analytical applications. Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K_D=80 nM) . Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC₉₀ of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research .

HY-P1682

Balixafortide POL6326	CXCR Arrestin	Cancer
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

HY-P3358

Antitumor agent-39	Peptides	Cancer
Antitumor agent-39 is a peptide compound with anticancer effect (US20050009751A1, compound 64) .

HY-P1935

Cyclo(Ala-Pro)	Biochemical Assay Reagents	Cancer
Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 .

HY-139425

Cyclo(Pro-Ala)	Biochemical Assay Reagents	Cancer
Cyclo(Pro-Ala) is an anticancer agent that has toxic to cancer cells such as A549, HCT-116, and HepG2 .

HY-P4286

H-Gly-Leu-Phe-OH	Peptides	Cancer
H-Gly-Leu-Phe-OH (GLF), an immunostimulatory tripeptide derived from α-lactalbumin, inhibits anticancer agent Etoposide-induced alopecia, epidermal thickening, and thinning of the adipocyte layer .

HY-P10777

ANG1009	Peptide-Drug Conjugates (PDCs)	Cancer
ANG1009 is a BBB-penatrable anticancer agent. ANG1009 is cytotoxic to a variety of tumor cells and can induce cell cycle arrest. ANG1009 can be used in the study of brain cancer .

HY-16532

Zoptarelin doxorubicin AEZS-108; AN-152	Peptide-Drug Conjugates (PDCs) GnRH Receptor	Cancer
Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro .

HY-P1351

Angiopep-2-Cys	Biochemical Assay Reagents	Cancer
Angiopep-2-cys is a conjugate of Angiopep-2 hydrochloride (HY-P2341) and cysteine. Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer .

HY-P10669

NDI-Lyso	Caspase Apoptosis	Cancer
NDI-Lyso is a lysosome-targeted anticancer agent that induces the formation of rigid long fibers in cancer cell lysosomes through an enzyme-instructed self-assembly (EISA) mechanism catalyzed by cathepsin B. This process triggers lysosomal swelling, membrane permeabilization (LMP), and membrane disruption, ultimately leading to cancer cell apoptosis via a non-classical caspase-independent pathway. NDI-Lyso exhibits significant selective anticancer activity in various cancer cell lines and drug-resistant cancer cells (IC₅₀ ~10 μM) while showing low toxicity to normal cells (IC₅₀ > 60 μM) .

Cat. No.	Product Name	Target	Research Area

HY-P99254

Racotumomab 1E10	Inhibitory Antibodies	Inflammation/Immunology Cancer
Racotumomab (Anti-Human NGcGM3 Recombinant Antibody) is an anti-idiotype monoclonal antibody (MAb). Racotumomab reacts to Neu-glycolyl (NeuGc)-containing gangliosides, sulfatides, and other antigens expressed in tumors. Racotumomab is an active anticancer agent for lung cancer .

HY-P99284

Dalotuzumab 1 Publications Verification MK-0646; h7C10	IGF-1R Apoptosis	Cancer
Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7669

Taccalonolide C	Structural Classification Classification of Application Fields Cardiacglycosides Source classification Plants Disease Research Fields Tacca chantrieri Andre Taccaceae Steroids Cancer	Others
Taccalonolides C is an anti-cancer agent .

HY-N9437

Betulin diacetate Betulin 3,28-diacetate	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Celastraceae Plants Maytenus hookeri Loes. Disease Research Fields Inflammation/Immunology	HIV
Betulin diacetate, a triterpene and derivative of Betulin, is an anti-AID agent and also possesses anti-cancer activity .

HY-12538

Graveoline Rutamine	Structural Classification Alkaloids Source classification Ruta graveolens Linn. Rutaceae Quinoline Alkaloids Plants	Apoptosis Autophagy Fungal
Graveoline (Rutamine) is an anti-cancer agent that can trigger apoptosis and autophagy in skin melanoma cells. Graveoline also exhibits antifungal activity .

HY-113462

α-Carotene	Structural Classification Classification of Application Fields Source classification Plants Food Research Other Terpenoids Microorganisms Terpenoids Pigments Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Umbelliferae Disease Research Fields Cancer	Others
α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer agents. α-Carotene is isolated from yellow-orange and dark-green vegetables .

HY-13748

Silybin A 5+ Cited Publications Silibinin A	Flavanonols Structural Classification Flavonoids Glycine soya Classification of Application Fields Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Disease Research Fields Cancer	Autophagy Reactive Oxygen Species
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

HY-136552

β-Bisabolene	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields Cancer	Others
β-Bisabolene is a sesquiterpene isolated from opoponax (Commiphora guidotti). β-Bisabolene, an **anti-cancer agent*, can be used for the study of breast cancer* .

HY-122944

20-Deoxocarnosol	Structural Classification Terpenoids Labiatae Diterpenoids Salvia deserta Schang Plants	Others
20-Deoxocarnosol (compound 7) is a potent *anti-cancer* agent that can be found in the roots of Salvia deserta. 20-Deoxocarnosol shows cytotoxicity in cancer cells .

HY-N9358

Argentinogenin	Structural Classification Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Others
Argentinogenin is a natural compound with anti-cancer activity that could be found in traditional Chinese agent Chan Su .

HY-N10782

Balanophonin	Balanophora japonica Makino Source classification Plants Balanophoraceae	Apoptosis COX TNF Receptor p38 MAPK
Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis .

HY-N12473

25-Deacetylcucurbitacin A	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Cucumis melo Linn.	JAK
25-Deacetylcucurbitacin A is a Cucurbitane-Type triterpenoid and has the potential to be an *anti-cancer* agent and JAK/STAT3 signaling pathway inhibitor .

HY-N3951

Glochidone	Triterpenes Structural Classification Phyllanthaceae Terpenoids Source classification Glochidion wrightii Benth. Plants	Others
Glochidone is an anti-cancer agent with IC₅₀s of 5.52 μM and 7.84 μM against HOP-62 and EPLC-272H cells, respectively .

HY-113064

Selenocystine 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Selenocystine is a broad-spectrum *anti-cancer* agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-N12603

Typhatifolin B	Structural Classification Flavonoids Typhaceae Flavonones Typha angustifolia L. Source classification Plants	Apoptosis
Typhatifolin B (Compd 2), an anti-cancer agent, could remarkably induce cell apoptosis and G0/G1 cycle arrest, as well as block cell migration and invasion .

HY-13629

Etoposide 110+ Cited Publications VP-16; VP-16-213	Infection Structural Classification Monophenols Classification of Application Fields Sinopodophyllum hexandrum (Royle) Ying Source classification Lignans Phenols Phenylpropanoids Plants Berberidaceae Disease Research Fields	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-N6866

Gomisin N	Structural Classification Neurological Disease Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Inflammation/Immunology Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer	Apoptosis
Gomisin N, isolated from Schisandra chinensis. Gomisin N has the potential for use in the treatment of allergy. Gomisin N is an anti-cancer agent candidate capable of inhibiting the proliferation and inducing the apoptosis in cancer .

HY-121309

Doxorubicinone 2 Publications Verification Adriamycin aglycone; Adriamycinone	Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively.

HY-N3974

Griffipavixanthone (+)-Griffipavixanthone	Structural Classification Flavonoids Source classification Guttiferae Garcinia schomburgkiana Pierre Plants Biflavones	Apoptosis
Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC₅₀: 4.58 mM) .

HY-13748R

Silybin A (Standard)	Flavanonols Structural Classification Flavonoids Glycine soya Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae	Autophagy Reactive Oxygen Species
Silybin A (Standard) is the analytical standard of Silybin A. This product is intended for research and analytical applications. Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

HY-113462R

α-Carotene (Standard)	Other Terpenoids Structural Classification Microorganisms Terpenoids Source classification Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Umbelliferae Plants	Others
α-Carotene (Standard) is the analytical standard of α-Carotene. This product is intended for research and analytical applications. α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer agents. α-Carotene is isolated from yellow-orange and dark-green vegetables .

HY-N11536

erythro-Austrobailignan-6	Structural Classification Saururaceae Saururus chinensis (Lour.) Baill. Source classification Lignans Phenylpropanoids Plants	Topoisomerase Apoptosis
erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK .

HY-N2059

Santalol	Structural Classification other families Classification of Application Fields Santalum album Linn. Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields Santalaceae Cancer	Apoptosis
Santalol is a mixture of α and β-isomer santalol. α-Santalol is found in sandalwood oil. α-Santalol is a promising anti-cancer agent against cancers such as oral, breast, prostate and skin cancer. Santalol has sedative activity .

HY-122783

Isogambogic acid	Structural Classification Xanthones Source classification Guttiferae Phenols Plants Garcinia hanburyi Hook. f.	Antibiotic
Isogambogic acid is an antibiotic and anti-cancer agent which efficiently elicit cell death in LLC and SK-LU-1 within a low micromolar range with IC₅₀s of 2.26 μM and 2.02 μM. Isogambogic acid can be used for cancer research .

HY-13629R

Etoposide (Standard)	Structural Classification Monophenols Sinopodophyllum hexandrum (Royle) Ying Source classification Lignans Phenols Phenylpropanoids Plants Berberidaceae	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic
Etoposide (Standard) is the analytical standard of Etoposide. This product is intended for research and analytical applications. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-121309R

Doxorubicinone (Standard)	Quinones Structural Classification Anthraquinones Source classification Endogenous metabolite	Endogenous Metabolite
Doxorubicinone (Standard) is the analytical standard of Doxorubicinone. This product is intended for research and analytical applications. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.

HY-N0794

Proanthocyanidins 3 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Plants Infection Flavonoids other families Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Inflammation/Immunology Disease Research Fields	Bacterial Fungal
Proanthocyanidin (Procyanidin) are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidin can be used as antioxidant and anti-cancers agent. Proanthocyanidin also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy. .

HY-16050

Plitidepsin 3 Publications Verification Aplidine; PM90001	Structural Classification Microorganisms Marine natural products Source classification Other marine organisms	DNA/RNA Synthesis SARS-CoV
Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K_D=80 nM) . Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC₉₀ of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research .

HY-N4103

Fucosterol	Structural Classification other families Classification of Application Fields Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields Steroids	PARP Endogenous Metabolite
Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities . Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research .

HY-B1357

Digitoxin 5+ Cited Publications	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Source classification Scrophulariaceae Plants Disease Research Fields Steroids	Bcl-2 Family Caspase Apoptosis HSV Na+/K+ ATPase Calcium Channel
Digitoxin is an *anti-cancer* agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 476 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Disease Research Fields	Topoisomerase ADC Cytotoxin AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-N12142

Anticancer agent 156	Structural Classification Classification of Application Fields Antibiotics Source classification Miliusa sinensis Finet et Gagnep. Plants Annonaceae Disease Research Fields Other Antibiotics Cancer	Others
Anticancer agent 156 (compound 11) is a powerful anticancer agent based on Miliusanes (anticancer lead molecule). Anticancer agent 156 effectively inhibits the growth of human cancer cells and shows significant cytotoxicity to gastric cancer cells .

HY-B0166

L-Ascorbic acid 55+ Cited Publications L-Ascorbate; Vitamin C	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Source classification Endocrine diseases Metabolic Disease Plants Endogenous metabolite Microorganisms Disease markers Moringaceae Nervous System Disorder Disease Research Fields	Reactive Oxygen Species Calcium Channel Apoptosis Endogenous Metabolite
L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-128498

Anticancer agent 182	Structural Classification Monophenols Source classification Phenols Muntingia calabura L. Plants Muntingiaceae	Others
Anticancer agent 182 (Compound 1) is a cytotoxic flavonoid compound isolated from the root ofMuntingia colabura L. Anticancer agent 182 exhibits anticancer activity .

HY-N11572

Anticancer agent 96	Structural Classification Terpenoids Pterocarpus macrocarpus Kurz Sesquiterpenes Source classification Plants Compositae	Others
Anticancer agent 96 (Compound 4) is an anticancer agent that shows cytotoxic activities against human cancer cells .

HY-16050R

Plitidepsin (Standard)	Structural Classification Microorganisms Marine natural products Source classification Other marine organisms	DNA/RNA Synthesis SARS-CoV
Plitidepsin (Standard) is the analytical standard of Plitidepsin. This product is intended for research and analytical applications. Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K_D=80 nM) . Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC₉₀ of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research .

HY-N11919

Anticancer agent 149	Structural Classification Source classification Phenols Polyphenols Plants Dioscorea membranacea Pierre ex Prain & Burkill Dioscoreaceae	Others
Anticancer agent 149 (compound 3) is an anticancer agent isolated from the rhizome of Dioscorea dioscorea (DM). Anticancer agent 149 exhibits selective cytotoxic activity against MCF-7 cells (IC₅₀=31.41 μM) .

HY-B1357R

Digitoxin (Standard)	Digitalis purpurea Linn. Structural Classification Microorganisms Source classification Scrophulariaceae Plants Steroids	Bcl-2 Family Caspase Apoptosis HSV Na+/K+ ATPase Calcium Channel
Digitoxin (Standard) is the analytical standard of Digitoxin. This product is intended for research and analytical applications. Digitoxin is an *anti-cancer* agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .

HY-N4103R

Fucosterol (Standard)	Structural Classification other families Classification of Application Fields Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields Steroids	PARP Endogenous Metabolite
Fucosterol (Standard) is the analytical standard of Fucosterol. This product is intended for research and analytical applications. Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities . Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research .

HY-15142A

Doxorubicin Hydroxydaunorubicin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields	ADC Cytotoxin Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV
Doxorubicin (Hydroxydaunorubicin), a broad-spectrum anthracycline antibiotic with cytotoxic properties, is an anti-cancer chemotherapy agent. Doxorubicin has fluorescence properties. Doxorubicin inhibits topoisomerase II with an IC₅₀ of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy . Doxorubicin inhibits human DNA topoisomerase I with an IC₅₀ of 0.8 μM .

HY-15142R

Doxorubicin (hydrochloride) (Standard) 1 Publications Verification	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Topoisomerase ADC Cytotoxin AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-163112

Anticancer agent 179	Structural Classification Monophenols Microorganisms Source classification Phenols	Others
Anticancer agent 179 (Compound 3) is a sambutoxin analogue. Anticancer agent 179 can impede migration of MDA-MB-231 breast cancer cells .

HY-N4047

Heveaflavone	Structural Classification Selaginella doederleinii Hieron. Source classification Phenols Polyphenols Selaginellaceae Plants	Others
Heveaflavone is an anticancer and antioxidant agent .

HY-W011641

(±)-Naringenin 3 Publications Verification	Cardiovascular Disease Structural Classification Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Polyphenols Plants Disease Research Fields	Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase
(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BK_Ca channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .

HY-B0166R

L-Ascorbic acid (Standard) 1 Publications Verification	Structural Classification Natural Products Microorganisms Moringa oleifera Lam. Source classification Disease markers Endocrine diseases Moringaceae Nervous System Disorder Plants Endogenous metabolite	Reactive Oxygen Species Calcium Channel Apoptosis Endogenous Metabolite
L-Ascorbic acid (Standard) is the analytical standard of L-Ascorbic acid. This product is intended for research and analytical applications. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-N2181

Acetylshikonin 1 Publications Verification	Quinones Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae Inflammation/Immunology Disease Research Fields	Cytochrome P450 Apoptosis Bacterial Autophagy
Acetylshikonin is an oral active anti-cancer, anti-inflammatory, antioxidant, anti-fertility, antibacterial, and neuroprotective agent. Acetylshikonin is a inhibitor of acetylcholinase (AChE) (IC₅₀=34.6 μM) and nonselective cytochrome P450. Acetylshikonin can induce Apoptosis and Autophagy in cancer cells. Acetylshikonin regulates blood glucose, liver fat metabolism, and renal fibrosis, and is used in the study of diabetes, diabetic nephropathy (DN), obesity, and nonalcoholic fatty liver disease (NAFLD) .

HY-N7279

Epiaschantin (+)-Epiaschantin	Structural Classification other families Hernandia nymphaeifolia (C. Presl) Kubitzki Source classification Lignans Phenylpropanoids Plants	Others
Epiaschantin is an anticancer agent. Epiaschantin shows antiproliferative activity .

HY-N5166

Ardeemin (-)-Ardeemin	Structural Classification Alkaloids Microorganisms Source classification Indole Alkaloids	P-glycoprotein
Ardeemin ((-)-Ardeemin) binds to the P-glycoprotein, preventing anticancer agent from being pumped out of cells. Ardeemin reverses the multidrug resistance phenotype of tumor cells and increases the sensitivity of tumor cells to anticancer agent in mammary carcinoma xenografts .

HY-N10444

Alterbrassicene B	Microorganisms Terpenoids Source classification Diterpenoids	Others
Alterbrassicene B is an anticancer agent, can be isolated from Alternaria brassicicola .

HY-163113

Anticancer agent 180	Structural Classification Microorganisms Source classification Phenols	Endogenous Metabolite
Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .

HY-N11510

Isocoreopsin Flavanocorepsin	Structural Classification Flavonoids Cercis chinensis Bunge Flavonones Source classification Plants Compositae	Others
Isocoreopsin (Flavanocorepsin) is an anticancer agent that can be isolated from Butea monosperma flowers .

HY-W505771

Seselin	Structural Classification Flavonoids Source classification Ficus erecta Thunb. var. beecheyana (Hook.et Arn.) King Plants Moraceae Other Flavonoids	Fungal
Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active .

Cat. No.	Product Name	Chemical Structure

HY-17393S

Carboplatin-d4
Carboplatin-d₄ is the deuterium labeled Carboplatin. Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.

HY-10227S

Bortezomib-d8
Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity[1][2].

HY-B0335S1

Tolfenamic acid-13C6
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-121309S

Doxorubicinone-d3
Doxorubicinone-d₃ is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.

HY-13629S1

Etoposide-13C,d3
Etoposide- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoposide. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy[1].

HY-13629S

Etoposide-d3
Etoposide-d3 (VP-16-d3) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-B2099S

Buformin-d9 hydrochloride
Buformin-d₉ (hydrochloride) is the deuterium labeled Buformin. Buformin (1-Butylbiguanide), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al)[1].

HY-121309S1

Doxorubicinone-13C,d3
Doxorubicinone- ¹³C,d₃ (Adriamycin aglycone- ¹³C,d₃) is ¹³C labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin . Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively.

HY-B0335S

Tolfenamic Acid-D4
Tolfenamic acid-d₄ is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1[1][2].

HY-109523S

Cerivastatin-d3 sodium

Cerivastatin-d₃ sodium is deuterated labeled Cerivastatin sodium (HY-109523). Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect .

HY-B0166S1

L-Ascorbic acid-13C

L-Ascorbic acid- ¹³C is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

HY-B0166S

L-Ascorbic acid-13C6

L-Ascorbic acid- ¹³C₆ is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

HY-B0166S8

L-Ascorbic acid-13C6-1

L-Ascorbic acid- ¹³C₆-1 (L-Ascorbate-1; Vitamin C- ¹³C₆-1) is a ¹³C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-135336S

(R)-Verapamil-d7 hydrochloride
(R)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents[1][2].

HY-N0453S

Hypericin-d10
Hypericin-d₁₀ is the deuterium labeled Hypericin. Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM.

HY-15287S

Nelfinavir-d3
Nelfinavir-d₃ (AG1341-d3) is the deuterium labeled Nelfinavir. Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent[1][2][3].

HY-B0077S1

Bendamustine-d8 hydrochloride
Bendamustine-d₈ (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].

HY-W008351S

L-Ribose-13C
L-Ribose- ¹³C is the ¹³C labeled L-Ribose. L-Ribose, a non-naturally occurring pentose, is an ideal starting material for use in synthesizing L-nucleosides analogues. Many anticancer and antiviral agents are synthesized based on a backbone of L-Ribose and i

HY-W015551S

trans-2-Decenal-d2
trans-2-Decenal-d₂ is deuterated labeled Coumarin (HY-N0709). Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity .

HY-15287S1

Nelfinavir-d4
Nelfinavir-d₄ is deuterated labeled Nelfinavir (HY-15287). Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (K_i=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .

HY-W702292

(R)-(+)-Verapamil-d6 hydrochloride
(R)-(+)-Verapamil-d₆ (hydrochloride) is deuterium labeled (R)-Verapamil (hydrochloride). (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents .

HY-13567S1

Bendamustine-d8
Bendamustine-d₈ is the deuterium labeled Bendamustine[1]. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties[2].

HY-B0294S

Flubendazole-d3
Flubendazole-d₃ is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic agent, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle[1][2].

HY-W010575S

(2R)-3-Amino-2-fluoropropanoic acid-13C3
(2R)-3-Amino-2-fluoropropanoic acid- ¹³C₃ is a ¹³C-labeled (2R)-3-Amino-2-fluoropropanoic acid. (2R)-3-Amino-2-fluoropropanoic acid is the catabolism of anticancer agent 5-Fluorouracil[1].

HY-17514S

Itraconazole-d5

Itraconazole-d₅ is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects[1][2][3].

HY-W653905

Amantadine-d15 hydrochloride

Amantadine-d₁₅ hydrochloride is deuterated labeled Amantadine. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .

HY-B0532AS

Trifluoperazine-d3 dihydrochloride

Trifluoperazine-d₃ (dihydrochloride) is deuterium labeled Trifluoperazine (dihydrochloride). Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].

HY-17514S2

Itraconazole-d9

Itraconazole-d₉ is the deuterium labeled Itraconazole[1]. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor[2][3][4][5].

HY-B0402S1

Amantadine-d6

Amantadine-d₆ is the deuterium labeled Amantadine[1]. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[2][3][4][5][6][7].

HY-N6746S1

Citrinin-13C13

Citrinin- ¹³C₁₃ (NSC 186- ¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

Cat. No.	Product Name		Classification

HY-153962

SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3		Azide
SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 is a Drug-Linker Conjugate for ADC. SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 consists of the anti-cancer agent SN38 (HY-13704) and a linker Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 (HY-131157). SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 can be used for synthesis of ADCs . SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151953

Antitubulin agent 1		Alkynes
Antitubulin agents-1 is an antitubulin agent that induces disruption of the microtubules (Microtubule/Tubulin) and increases α-tubulin acetylation. Antitubulin agents-1 has anticancer effects . Antitubulin agent 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-155541

Antitumor agent-110		Alkynes
Antitumor agent-110 (compound 13) is an anticancer imidazotetrazine with good permeability properties. Antitumor agent-110 arrests cell cycel at G2/M phase, and induces apoptosis . Antitumor agent-110 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16247

Apoptone HE3235		Alkynes
Apoptone, synthetic analogue of 3β-androstanediol, is an orally bioavailable *anticancer* agent. Apoptone is active in rodent models of prostate and breast cancer . Apoptone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-43058

5'-O-DMT-ibu-rG 5'-O-DMT-N2-isobutyrylguanosine		Nucleoside Phosphoramidites
5'-O-DMT-ibu-rG is a useful model for a new class of DNA binding molecules for the development of potent and selective anti-cancer agents .

HY-N4103

Fucosterol		Cholesterol
Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities . Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research .

HY-155882

mPEG-amine (MW 750) mPEG-NH2 (MW 750)		Polymers
mPEG-amine (MW 750) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-125924

DSPE-PEG-Amine, MW 2000 ammonium 1 Publications Verification DSPE-PEG-NH2, MW 2000 ammonium; DSPE-PEG(2000) Amine ammonium		Pegylated Lipids
DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents .

HY-W115607

PEG-bis-amine (MW 8000) Poly(ethylene glycol)-bis-amine (MW 8000)		Polymers
PEG-bis-amine (MW 8000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155880

mPEG-amine (MW 350) mPEG-NH2 (MW 350)		Polymers
mPEG-amine (MW 350) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155883

mPEG-amine (MW 3400) mPEG-NH2 (MW 3400)		Polymers
mPEG-amine (MW 3400) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-152437

3’-Amino-3’-deoxy-5-methyl uridine		Nucleosides and their Analogs
3’-Amino-3’-deoxy-5-methyl uridine, Anticancer antiviral agent is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-155881

mPEG-amine (MW 550) mPEG-NH2 (MW 550)		Polymers
mPEG-amine (MW 550) can synthesize folate-conjugated polymer micelles for encapsulation of anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-155884

mPEG-amine (MW 4000) mPEG-NH2 (MW 4000)		Polymers
mPEG-amine (MW 4000) can be used to synthesize folate-conjugated polymer micelles for encapsulating anticancer agent 9-nitrocamptothecin (HY-16560). folate-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-W591632

PEG-bis-amine (MW 1000) Poly(ethylene glycol)-bis-amine (MW 1000)		Polymers
PEG-bis-amine (MW 1000) synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR).

HY-152313

2-Bromoadenosine		Nucleosides and their Analogs
2-Bromoadenosine, antimalarial agent is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-W440919

DSPE-PEG-Rhodamine, MW 2000		Pegylated Lipids Fluorescent Lipids
DSPE-PEG-Rhodamine, MW 2000 is a dye functionalized phospholipid. The amphiphilic polymer can form lipid bilayer in water and be used to encapsulate therapeutic agents, such as liposomal anticancer drug or mRNA vaccine. Rhodamine has maximum absorption at 570 nm and emission around 595 nm and can be easily traced using an imaging technique.

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