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Results for "

highly potent

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (547) Cardiovascular Disease (104) Endocrinology (44) Infection (138) Inflammation/Immunology (170) Metabolic Disease (96) Neurological Disease (234)
Click Chemistry:	PROTAC Synthesis (3) Azide (4) Alkynes (10)
Oligonucleotides:	Nucleosides and their Analogs (2) Aptamers (4) Cationic Lipids (1)

1165

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141680

CPS2 1 Publications Verification	PROTACs CDK	Cancer
CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader (IC₅₀= 24 nM). CPS2 can be used for the research of acute myeloid leukemia .

HY-P2026

A 71915	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pK_i= 9.18). A 71915 displaces [ ¹²⁵I]ANP dose dependently, with a K_i of 0.65 nM. A71915( pA₂= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells .

HY-105117

Fantofarone 1 Publications Verification SR 33557	Calcium Channel Parasite	Infection
Fantofarone is a highly potent Calcium Channel antagonist.

HY-132880

GSK251	PI3K	Cancer
GSK251 is a highly potent, highly selective, orally bioavailable inhibitor of PI3Kδ with a novel binding mode.

HY-100814

(R)-CPP 1 Publications Verification	iGluR	Neurological Disease
(R)-CPP is a highly potent NMDA receptor antagonist .

HY-10934

Mibampator LY451395	iGluR	Neurological Disease
Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.

HY-13500

GSK343 25+ Cited Publications	Histone Methyltransferase Autophagy	Cancer
GSK343 is a highly potent and selective EZH2 inhibitor with an IC₅₀ of 4 nM.

HY-10284

Linagliptin 5+ Cited Publications BI 1356	Dipeptidyl Peptidase Autophagy Ferroptosis	Metabolic Disease
Linagliptin is a highly potent, selective DPP-4 inhibitor with IC₅₀ of 1 nM.

HY-P1331

BAM-22P Bovine adrenal medulla-22P	Opioid Receptor	Neurological Disease
BAM-22P, a highly potent opioid peptide, is a potent opioid agonist.

HY-117151

A-315675	Influenza Virus	Inflammation/Immunology
A-315675 is a potent highly potent inhibitor of A and B strain influenza virus neuraminidases inhibitor .

HY-13074

VO-Ohpic trihydrate 30+ Cited Publications	PTEN Autophagy	Cancer
VO-Ohpic trihydrate is a highly potent inhibitor of PTEN with an IC₅₀ of 46±10 nM.

HY-14981

GSK2334470 5+ Cited Publications	PDK-1	Cancer
GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC₅₀ of 10 nM.

HY-122280

Aerobactin	Endogenous Metabolite	Infection
Aerobactin is a siderophore produced by bacteria. Aerobactin is a highly potent pathogenic factor .

HY-70061

TCS7010 2 Publications Verification	Aurora Kinase Apoptosis	Cancer
TCS7010 is a potent and highly selective Aurora A inhibitor with with an IC₅₀ of 3.4 nM.

HY-10036

Glucagon receptor antagonist-1	GCGR	Metabolic Disease
Glucagon receptor antagonist-1 is a highly potent glucagon receptor antagonist.

HY-50159

Glucagon receptor antagonist-3	GCGR	Metabolic Disease
Glucagon receptor antagonist-3 is a highly potent glucagon receptor antagonist.

HY-50158

Glucagon receptor antagonist-2	GCGR	Metabolic Disease
Glucagon receptor antagonist-2 is a highly potent glucagon receptor antagonist.

HY-12829

SR-3306	JNK	Neurological Disease
SR-3306 is a selective, potent, highly brain penetrant JNK inhibitor.

HY-11999

CGI-1746 5+ Cited Publications	Btk Autophagy	Inflammation/Immunology
CGI-1746 is a potent and highly selective inhibitor of the Btk with IC₅₀ of 1.9 nM.

HY-15199

Agerafenib hydrochloride CEP-32496 hydrochloride; RXDX-105 hydrochloride	Raf	Cancer
Agerafenib hydrochloride is a highly potent and orally efficacious inhibitor of BRAF ^V600E with a K_d of 14 nM.

HY-116067

VU0404251	mGluR	Neurological Disease
VU0404251 is a highly potent positive allosteric modulator of mGlu for the study of psychosis .

HY-107418

Tropifexor 5+ Cited Publications LJN452	FXR Autophagy	Cardiovascular Disease
Tropifexor (LJN452) is a highly potent agonist of FXR with an EC₅₀ of 0.2 nM .

HY-123672

Lovastatin hydroxy acid sodium Mevinolinic acid sodium	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a K_i of 0.6 nM .

HY-12510

Methoxy-PEPy	mGluR	Neurological Disease
Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.

HY-X0150

JSH-150	CDK	Cancer
JSH-150 is a highly selective and potent CDK9 inhibitor with an IC₅₀ of 1 nM.

HY-120973A

(S)-Butaprost free acid	Prostaglandin Receptor	Endocrinology
(S)-Butaprost (free acid) is a potent and highly selective agonist of EP2 receptor .

HY-125879

DS08210767	PTHR	Metabolic Disease Endocrinology
DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC₅₀ of 90 nM .

HY-16733

Verinurad RDEA3170	URAT1	Metabolic Disease
Verinurad (RDEA3170) is a highly potent and specific URAT1 inhibitor with an IC₅₀ of 25 nM .

HY-107596

SR-3576	JNK	Others
SR-3576 is a highly potent and selective JNK3 inhibitor with an IC₅₀ of 7 nM .

HY-115719

CASK-IN-1	Ser/Thr Kinase	Neurological Disease
CASK-IN-1 is a highly potent and selective CASK inhibitor with a K_d value of 0.022 μM.

HY-168145

MAGL-IN-19	MAGL	Cancer
MAGL-IN-19 (compund 7o) is a highly potent and selective MAGL inhibitor .

HY-111368

EBI-1051	MEK	Cancer
EBI-1051 is a highly potent and orally efficacious MEK inhibitor with an IC₅₀ of 3.9 nM.

HY-102080

SAFit2 5 Publications Verification	FKBP	Cancer
SAFit2 is a highly potent, highly selective FK506-binding protein 51 (FKBP51) inhibitor with a K_i of 6 nM and also enhances AKT2-AS160 binding .

HY-16925

MI-503 5+ Cited Publications	Epigenetic Reader Domain	Cancer
MI-503 is a highly potent and orally bioavailable small molecule inhibitor of the menin-mLL interaction.

HY-11090A

DPC423	Factor Xa	Cardiovascular Disease
DPC423 is a highly potent, selective, and orally active factor Xa inhibitor with a K_i of 0.15 nM .

HY-14274

Anastrozole 4 Publications Verification ZD1033	Cytochrome P450	Cancer
Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC₅₀ of 15 nM.

HY-12477

PF-06447475 4 Publications Verification	LRRK2	Neurological Disease
PF-06447475 is a highly potent, selective and brain penetrant LRRK2 inhibitor with an IC₅₀ of 3 nM.

HY-13252

MK-5108 4 Publications Verification VX-689	Aurora Kinase Autophagy	Cancer
MK-5108 is a highly potent and specific inhibitor of Aurora A kinase with an IC₅₀ value of 0.064 nM.

HY-139868

BAY-091	PI5P4K	Cancer
BAY-091 is a novel potent and highly selective inhibitor of the kinase PIP4K2A.

HY-100471

Esaxerenone 2 Publications Verification CS-3150; XL-550	Mineralocorticoid Receptor	Cardiovascular Disease
Esaxerenone (CS-3150) is a highly potent and selective non-steroidal mineralocorticoid receptor antagonist .

HY-19535B

Nemiralisib succinate GSK2269557 succinate	PI3K	Cancer
Nemiralisib Succinate is a potent and highly selective PI3Kδ inhibitor with a pK_i of 9.9.

HY-105192

CP-122288	5-HT Receptor	Neurological Disease Inflammation/Immunology
CP-122288, a highly potent inhibitor of neurogenic inflammation, can be used in migraine study .

HY-19809

MI-463 1 Publications Verification	Epigenetic Reader Domain	Cancer
MI-463 is a highly potent and orally bioavailable small molecule inhibitor of the menin-mLL interaction.

HY-118578

Furalaxyl CGA 38140	Fungal	Infection
Furalaxyl (CGA 38140) is a potent fungicide. Furalaxyl is highly selective to fungi of the order of the Peronosporales .

HY-18683

Centrinone-B 5+ Cited Publications LCR-323	Polo-like Kinase (PLK)	Cancer
Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a K_i of 0.59 nM.

HY-P0214

Autocamtide-2-related inhibitory peptide	CaMK Autophagy	Neurological Disease
Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

HY-15512A

OTSSP167 hydrochloride 15+ Cited Publications OTS167 hydrochloride	MELK	Cancer
OTSSP167 (OTS167) hydrochloride is a highly potent and ATP-competitive MELK inhibitor with IC₅₀ value of 0.41 nM.

HY-P1145

Glucagon-like peptide 1 (1-37), human HuGLP-1	GCGR	Metabolic Disease
Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.

HY-114418

MMP3 inhibitor 1 1 Publications Verification	MMP	Cancer
MMP3 inhibitor 1 is a potent and highly selective MMP-3 inhibitor with an IC₅₀ of 1 nM .

HY-P0069

D-JNKI-1 5+ Cited Publications AM-111; XG-102	JNK	Others
D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.

Cat. No.	Product Name

HY-L023

Toxins for Antibody-Drug Conjugate Research Library

112 compounds

Antibody-Drug Conjugates (ADCs), a new class of treatment for cancer, are composed with a monoclonal antibody, a linker and a cytotoxic agent also referred to as a payload. To date, several ADCs have received market approval and more than 60 ADCs are currently in clinical trials. ADCs are one of the fastest growing classes of oncology drugs worldwide.

The payload or cytotoxic agent is the most important unit in the ADC. ADC has the capability to kill cancer cell depending on the potency of the payload. MCE provides 112 highly potent cytotoxins that contain auristatin derivatives, maytansinoids, calicheamicin, duocarmycin, pyrrolobenzodiazepines (PBDs), etc.

Cat. No.	Product Name	Type

HY-15659G

Wnt-C59 (GMP) C59 (GMP)	Fluorescent Dye
Wnt-C59 (C59) GMP is a GMP grade Wnt-C59 (HY-15659). Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC₅₀ of 74 pM.

HY-15682G

TTNPB (GMP) Ro 13-7410 (GMP); Arotinoid acid (GMP); AGN191183 (GMP)	Fluorescent Dye
TTNPB (Ro 13-7410) (GMP) is TTNPB (HY-15682) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TTNPB is a highly potent retinoic acid receptor (RAR) agonist .

HY-16700G

PNU-159682 (GMP)	Fluorescent Dye
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

HY-15794G

Nemorubicin (GMP)

Methoxymorpholinyl doxorubicin (GMP); FCE 23762 (GMP); PNU 152243 (GMP)

Fluorescent Dye

Nemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin (HY-15794). Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .

Cat. No.	Product Name	Type

HY-145795

OF-02	Drug Delivery
OF-02 is an alkenyl amino alcohol (AAA) ionizable lipid for highly potent in vivo mRNA delivery.

HY-W000357

4-(Imidazol-1-yl)phenol	Biochemical Assay Reagents
4-(Imidazol-1-yl)phenol is a highly potent signal enhancer in a horseradish peroxidase (HRP)-luminol chemiluminescence (CL) immunoassay .

HY-NP101

Highly purified Type I collagen, from bovine skin

Bovine Type I collagen, immunization grade

Native Proteins

Highly purified Type I collagen, from bovine skin (Bovine Type I collagen, immunization grade) plays an important role in the structure and function of skin, bone, tendons, and many others. Type I collagen potently stimulates angiogenesis in vitro and in vivo. Highly purified Type I collagen, from bovine skin is an immunization grade that can be used for immunization to generate antibodies .

HY-15659G

Wnt-C59 (GMP) C59 (GMP)	Biochemical Assay Reagents
Wnt-C59 (C59) GMP is a GMP grade Wnt-C59 (HY-15659). Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC₅₀ of 74 pM.

HY-15682G

TTNPB (GMP) Ro 13-7410 (GMP); Arotinoid acid (GMP); AGN191183 (GMP)	Biochemical Assay Reagents
TTNPB (Ro 13-7410) (GMP) is TTNPB (HY-15682) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TTNPB is a highly potent retinoic acid receptor (RAR) agonist .

HY-16700G

PNU-159682 (GMP)	Biochemical Assay Reagents
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

HY-15794G

Nemorubicin (GMP)

Methoxymorpholinyl doxorubicin (GMP); FCE 23762 (GMP); PNU 152243 (GMP)

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P99463

Batiraxcept AVB-500; AVB-S6-500	TAM Receptor	Cancer
Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to GAS6 and inhibits the interaction of GAS6 with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro and inhibiting metastatic disease in nonclinical models of aggressive human cancers. Batiraxcept is available for studies in advanced or metastatic clear cell renal cell carcinoma (ccRCC) and platinum sensitive recurrent ovarian cancer .

HY-P99483

Blontuvetmab AT 004; VT 007	CD20 Adenosine Receptor	Cancer
Blontuvetmab (AT 004) is a caninized CD20 monoclonal antibody and is also a potent, selective, highly potent antagonist of A2aR receptor. Blontuvetmab behaves as Nociceptin (HY-P0183)/Orphanin (HY-P0183) FQ receptor (NOP) agonists displaying weak NOP affinity. Blontuvetmab inhibits 5'-N-Ethylcarboxamidoadenosine (NECA)-mediated A2aR activation and significantly reverses the ability of adenosine to suppress CD8 T cell activation, increasing levels of cytokines such as IFN-γ. Blontuvetmab Blontuvetmab can be used for the research of Canine B-cell lymphoma .

HY-141606

Anetumab ravtansine BAY 94-9343	Microtubule/Tubulin Antibody-Drug Conjugates (ADCs)	Cancer
Anetumab ravtansine (BAY 94-9343) is a selective and highly potent antibody-drug conjugate (ADC) to target maytansinoid tubulin. Anetumab ravtansine consists of a human anti-mesothelin antibody conjugated to the maytansinoid tubulin inhibitor DM4. Anetumab ravtansine shows antitumor efficacy correlated with the amount of mesothelin expressed in patient-derived xenograft tumor models .

HY-P99612

Farletuzumab ecteribulin MORAb-202	Antibody-Drug Conjugates (ADCs)	Cancer
Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folate receptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity.

HY-141599

Camidanlumab tesirine ADCT 301	Antibody-Drug Conjugates (ADCs) Interleukin Related	Cancer
Camidanlumab tesirine (ADCT 301) is an ADC comprising HuMax-TAC, a human IgG1 mAb directed against human CD25, stochastically conjugated through a dipeptide cleavable linker to a pyrrolobenzodiazepine (PBD) dimer warhead. Camidanlumab tesirine has a drug–antibody ratio (DAR) of 2.3. Camidanlumab tesirine binds human CD25 with picomolar affinity. Camidanlumab tesirine has highly potent and selective cytotoxicity against a panel of CD25-expressing human lymphoma cell lines .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122280

Aerobactin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite
Aerobactin is a siderophore produced by bacteria. Aerobactin is a highly potent pathogenic factor .

HY-13674

Maytansine NSC 153858	Alkaloids Other Alkaloids Source classification Celastraceae Maytenus hookeri Loes. Plants Disease Research Fields Cancer	Microtubule/Tubulin
Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations .

HY-16982

Cercosporamide (-)-Cercosporamide	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Manihot esculenta Crantz Euphorbiaceae Plants Disease Research Fields	Fungal MNK PKC
Cercosporamide is a highly potent, ATP-competitive PKC kinase inhibitor targeting to PKC1, with an IC₅₀ of <50 nM and a K_i of <7 nM. Cercosporamide is a unique Mnk inhibitor.

HY-15762

Valdecoxib 3 Publications Verification SC 65872	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX Endogenous Metabolite
Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-117778

SF2312	Structural Classification Natural Products Microorganisms Source classification	Enolase Bacterial Antibiotic
SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent Enolase inhibitor with IC₅₀s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions .

HY-N1520

Rediocide A	Structural Classification Terpenoids Source classification Diterpenoids Euphorbiaceae Plants	Others
Rediocide A is a highly modified daphnane with potent insecticidal activity. Rediocide A can be isolated from Trigonostemon reidioides .

HY-101472

Closthioamide	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Phenols Polyphenols Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial
Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against Ec, MRSA, VRE and Mv), with MICs of 9.00 μM, 0.58 μM, 0.58 μM and 72.03 μM respectively.

HY-113631

Amorfrutin B	Structural Classification Monophenols Leguminosae Source classification Phenols Amorpha fruticosaL. Plants	PPAR
Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with K_i values of 19 nM and EC₅₀ values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities .

HY-118834

Teleocidin A1 Lyngbyatoxin A	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids Cancer	PKC
Teleocidin A1 (Lyngbyatoxin A), a highly toxic skin irritant, is a potent activator of protein kinase C (PKC). Teleocidin A1 shows antiproliferative activity against HeLa cancer cells (IC₅₀=9.2 nM) .

HY-15762R

Valdecoxib (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	COX Endogenous Metabolite
Valdecoxib (Standard) is the analytical standard of Valdecoxib. This product is intended for research and analytical applications. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-13434

Ionomycin Maximum Cited Publications 68 Publications Verification SQ23377	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

HY-B0425A

Novobiocin sodium 5+ Cited Publications Albamycin sodium; Cathomycin sodium	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics Cancer	Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP
Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity .

HY-N10539

Shishijimicin C	Alkaloids Structural Classification Natural Products Classification of Application Fields Animals Pyridine Alkaloids Disease Research Fields Indole Alkaloids Cancer	Others
Shishijimicin C is a novel antitumor agent found from the Ascidian Didemnum proliferum. Shishijimicin C shows anti-tumor activity with highly potent cytotoxicities . Shishijimicin C is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N0416

Cucurbitacin B 5+ Cited Publications	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Trichosanthes cucumerina L. Plants Endogenous metabolite Disease Research Fields Cancer	HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

HY-N0315

Allicin 5+ Cited Publications Diallyl thiosulfinate	Infection Structural Classification Natural Products Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields A．Sativam L. var．Viviparum Regel	Bacterial Antibiotic
Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains .

HY-125780R

5-Phenylhydantoin (Standard)	Microorganisms Source classification	Drug Metabolite
Dasatinib (monohydrate) (Standard) is the analytical standard of Dasatinib (monohydrate). This product is intended for research and analytical applications. Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively . Dasatinib monohydrate also induces apoptosis and autophagy.

HY-108485

Damnacanthal	Structural Classification Classification of Application Fields Source classification Plants Infection Quinones Monophenols Anthraquinones Morinda citrifolia Linn. Rubiaceae Phenols Inflammation/Immunology Disease Research Fields	Src Apoptosis Fungal
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 ^lck tyrosine kinase activity. Natural Damnacanthal inhibits p56 ^lck autophosphorylation and phosphorylation of exogenous substrates with IC₅₀s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against *Candida albicans* .

HY-B0290A

Pranlukast hemihydrate 2 Publications Verification ONO-1078 hemihydrate	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Leukotriene Receptor Endogenous Metabolite
Pranlukast hemihydrate is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [ ³H]LTE₄, [ ³H]LTD₄, and [ ³H]LTC₄ bindings to lung membranes with K_is of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

HY-B0290

Pranlukast 2 Publications Verification ONO-1078	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Leukotriene Receptor Endogenous Metabolite
Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [ ³H]LTE₄, [ ³H]LTD₄, and [ ³H]LTC₄ bindings to lung membranes with K_is of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

HY-13434A

Ionomycin calcium Maximum Cited Publications 68 Publications Verification SQ23377 calcium	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .

HY-113962

7α,25-Dihydroxycholesterol 2 Publications Verification 7α,25-OHC	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	EBI2/GPR183 Endogenous Metabolite
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC₅₀=140 pM; K_d=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells .

HY-17387

(-)-Huperzine A 5 Publications Verification Huperzine A	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Anti-aging Terpenoids Huperziaceae Sesquiterpenes Pyridine Alkaloids Huperzia serrata Plants Disease Research Fields	Cholinesterase (ChE) Apoptosis iGluR
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

HY-B0425AR

Novobiocin (sodium) (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Antibiotics Source classification Antiviral Antibacterial Disease Research Other Antibiotics	Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP
Novobiocin (sodium) (Standard) is the analytical standard of Novobiocin (sodium). This product is intended for research and analytical applications. Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity .

HY-N1243

Tubulysin B	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis
Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC₅₀ values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties .Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N0315R

Allicin (Standard) Diallyl thiosulfinate (Standard)	Structural Classification Natural Products Liliaceae Source classification Plants A．Sativam L. var．Viviparum Regel	Bacterial Antibiotic
Allicin (Standard) is the analytical standard of Allicin. This product is intended for research and analytical applications. Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains[1][2].

HY-B0290R

Pranlukast (Standard)	Structural Classification Alkaloids Other Alkaloids Source classification Endogenous metabolite	Leukotriene Receptor Endogenous Metabolite
Pranlukast (Standard) is the analytical standard of Pranlukast. This product is intended for research and analytical applications. Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [ ³H]LTE₄, [ ³H]LTD₄, and [ ³H]LTC₄ bindings to lung membranes with K_is of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

HY-N10534

Lewis X trisaccharide Lewis X	Infection Structural Classification Natural Products Polysaccharides Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides Cancer	Parasite
Lewis X trisaccharide (Lewis X, Le ^x) is a potent T_H2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis .

HY-N0416R

Cucurbitacin B (Standard)	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Trichosanthes cucumerina L. Plants Endogenous metabolite	HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX
Cucurbitacin B (Standard) is the analytical standard of Cucurbitacin B. This product is intended for research and analytical applications. Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

HY-N2346

Tubulysin E	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin E is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin E can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin E displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin E inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7049

Tubulysin F	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin F is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin F can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin F displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin F inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7052

Tubulysin I	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7053

Tubulysin M	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7050

Tubulysin G	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin G is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin G can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin G displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin G inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-10571

Delavirdine 3 Publications Verification U 90152; BHAP-U 90152	Infection Classification of Application Fields Disease Research Fields	HIV Reverse Transcriptase
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-N2348

Tubulysin D	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2347

Tubulysin C	Structural Classification Natural Products Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin C is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin C can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin C displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin C inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7051

Tubulysin H	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin H is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin H can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin H displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin H inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-113366

Prostaglandin J2 PGJ2	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with K_is of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC₅₀ value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) .

Cat. No.	Product Name	Chemical Structure

HY-B0202S

Irbesartan-d4
Irbesartan-d₄ is the deuterium labeled Irbesartan, which is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist.

HY-10268S

Betrixaban-d6
Betrixaban-d₆ is a deuterium labeled Betrixaban. Betrixaban is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor[1].

HY-B0515AS1

Ibandronic acid-d3
Ibandronic acid-d₃ is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

HY-B0515AS

Ibandronic Acid-d3 sodium salt
Ibandronic Acid-d₃ (sodium) is the deuterium labeled Ibandronic acid. Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis[1][2].

HY-123672S

Lovastatin-d3 hydroxy acid sodium
Lovastatin-d₃ hydroxy acid (sodium) is the deuterium labeled Lovastatin hydroxy acid sodium. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].

HY-B0202S1

Irbesartan-d6
Irbesartan-d₆ is the deuterium labeled Irbesartan. Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

HY-10284S5

Linagliptin-d6
Linagliptin-d₆ (BI 1356-d₆) is deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC₅₀ of 1 nM.

HY-10284S4

Linagliptin-d5
Linagliptin-d₅ (BI 1356-d₅) is deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC₅₀ of 1 nM.

HY-12857S

Brigatinib-13C6
Brigatinib- ¹³C₆ is the ¹³C-labeled Brigatinib. Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor, with an IC50 of 0.6 nM[1].

HY-14274S

Anastrozole-d12
Anastrozole-d₁₂ is the deuterium labeled Anastrozole. Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM[1][2].

HY-15592AS

Cabotegravir-d3 sodium
Cabotegravir-d₃ (sodium) is the deuterium labeled Cabotegravir sodium. Cabotegravir sodium is a highly potent HIV integrase inhibitor with an IC50 value of 2.5 nM for HIVADA. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltr

HY-16346S

Netupitant-d6
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist[1].

HY-17621S

Sparsentan-d5
Sparsentan-d₅ is deuterium labeled Sparsentan. Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1].

HY-17596S

Closantel-13C6
Closantel- ¹³C₆ is the ¹³C₆ labeled Closantel. Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.

HY-10284S3

Linagliptin-d3-1
Linagliptin-d3-1 (BI 1356-d3-1) is the deuterium labeled Linagliptin (HY-10284). Linagliptin is a highly potent, selective DPP-4 inhibitor with IC₅₀ of 1 nM .

HY-107327S

Carazolol-d7
Carazolol-d₇ is the deuterium labeled Carazolol (HY-107327). Carazolol is a highly potent antagonist of β₁/β₂ adrenoceptor. Carazolol is also a potent, selective β₃-adrenoceptor agonist. Carazolol can be used in the research of hypertension .

HY-50903S

Rivaroxaban-d4 1 Publications Verification
Rivaroxaban-d₄ is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent，selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM)[1][2].

HY-107327S1

Carazolol-d7 hydrochloride
Carazolol-d₇ (hydrochloride) is the deuterium labeled Carazolol hydrochloride (HY-W517264). Carazolol hydrochloride is a highly potent antagonist of β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-W777156

Carazolol-d6 hydrochloride
Carazolol-d₆ (hydrochloride) is deuterium labeled Carazolol hydrochloride (HY-W517264). Carazolol hydrochloride is a highly potent antagonist of β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-142283BS

N-Desmethyl dosimertinib-d5
N-Desmethyl dosimertinib-d₅ is the deuterium labeled Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].

HY-15605S

Encorafenib-13C,d3
Encorafenib- ¹³C,d₃ is the ¹³C- and deuterium labeled Encorafenib. Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM).

HY-142283CS

N-Methyl-dosimertinib-d5
N-Methyl-dosimertinib-d₅ is the deuterium labeled of Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].

HY-12857S2

Brigatinib-d11
Brigatinib-d₁₁ (AP-26113-d₁₁) is deuterium labeled Brigatinib. Brigatinib (AP-26113) is a highly potent, selective and orally active ALK inhibitor, with an IC₅₀ of 0.6 nM. Brigatinib can be used for research of NSCLC .

HY-15531S

Venetoclax-d8
Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].

HY-10268S2

Betrixaban-13C6
Betrixaban- ¹³C₆ (PRT054021- ¹³C₆) is ¹³C labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban shows antithrombotic effect .

HY-14136S

Rimonabant-d10
Rimonabant-d₁₀ is deuterium labeled Rimonabant. Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

HY-10268S1

Betrixaban-d4
Betrixaban-d₄ (PRT054021-d₄) is deuterium labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban shows antithrombotic effect .

HY-15777S

Ribociclib-d6
Ribociclib-d₆ is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].

HY-15777AS

Ribociclib-d6 hydrochloride
Ribociclib-d₆ (hydrochloride) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].

HY-14137S

Rimonabant-d10 hydrochloride
Rimonabant-d₁₀ (hydrochloride) is the deuterium labeled Rimonabant hydrochloride. Rimonabant hydrochloride (SR 141716A hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant hHydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3)[1][2].

HY-15762S

Valdecoxib-d3
Valdecoxib-d₃ is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain[1][2].

HY-10284S

Linagliptin-d4
Linagliptin-d₄ is deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM. Linagliptin-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100441S3

Treprostinil-d7
Treprostinil-d7 (UT-15-d7) is a deuterated version of Treprostinil (HY-100441). Treprostinil is a highly potent DP1 and EP2 agonist with EC50s of 0.6 nM and 6.2 nM, respectively .

HY-P1033S

[Pyr1]-Apelin-13, Gly(15N) TFA
Pyr1]-Apelin-13, Gly(15N) TFA is a Gly ¹⁵N labeled [Pyr1]-Apelin-13. [Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor agonist .

HY-15531S1

Venetoclax-d6
Venetoclax-d₆ (ABT-199-d₆) is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy .

HY-15777S1

Ribociclib-d8
Ribociclib-d₈ is the deuterium labeled Ribociclib[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[2].

HY-15408S

Trelagliptin-13C,d3
Trelagliptin-13C,d3 is a deuterated labeled Trelagliptin . Trelagliptin (SYR-472) is a potent, orally active and highly selective DPP-4 inhibitor with an IC₅₀ of 4 nM. Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM) .

HY-10181S1

Dasatinib-d4

Dasatinib-d₄ (BMS-354825-d₄) is deuterium labeled Dasatinib. Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The K_is are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC₅₀s of <1.0 nM and 0.5 nM, respectively . Dasatinib also induces apoptosis and autophagy.

HY-18986S

SAR405838-d10
SAR405838-d₁₀ (MI-77301-d₁₀) is the deuterium labeled SAR405838 (HY-18986). SAR405838 (MI-77301), an analog of MI-773, is a highly potent and selective MDM2-p53 interaction inhibitor. SAR405838 binds to MDM2 with a K_i of 0.88 nM. SAR405838 induces apoptosis and has potent antitumor activity .

HY-16106S1

Talazoparib-d4
Talazoparib-d₄ (BMN-673-d₄) is deuterium labeled Talazoparib. Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with K_is of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity .

HY-10284S1

Linagliptin-13C,d3
Linagliptin- ¹³C,d₃ is the ¹³C- and deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM. Linagliptin-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10237S

Boceprevir-d9
Boceprevir-d₉ is the deuterium labeled Boceprevir. Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay[1][2][3][4][5]. Boceprevir inhibits SARS-CoV-2 3CLpro activity[6].

HY-113962S

7α,25-Dihydroxycholesterol-d6
7α,25-Dihydroxycholesterol-d₆ is deuterium labeled 7α,25-Dihydroxycholesterol. 7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly

HY-14877S1

Anagliptin-d7
Anagliptin-d₇ (SK-0403-d₇) is deuterium labeled Anagliptin. Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC₅₀s of 68 nM and 60 nM, respectively .

HY-14605BS

Rasagiline-13C3 mesylate racemic

Rasagiline- ¹³C₃ (mesylate racemic) is a ¹³C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor[1]. Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605S

Rasagiline-13C3 mesylate
Rasagiline- ¹³C₃ ((R)-AGN1135- ¹³C₃; TVP1012- ¹³C₃) mesylate is the deuterium labeled Rasagiline (mesylate) (HY-14605) . Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively .

HY-B0290S1

Pranlukast-d4
Pranlukast-d₄ is deuterium labeled Pranlukast. Pranlukast is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [3H]LTE4, [3H]LTD4, and [3H]LTC4 bindings to lung membranes with Kis of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

HY-10241S

Simeprevir-13C,d3

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].

HY-A0014S

Ramelteon-d5

Ramelteon-d₅ is deuterium labeled Ramelteon. Ramelteon is a potent, highly selective, and orally active agonist of MT1/MT2 with Ki values of 14 and 112 pM, respectively. Ramelteon has the potential for the research of insomnia. Ramelteon consistently reduces sleep onset after long-term treatment, with no next-morning residual effects or rebound insomnia or withdrawal symptoms upon discontinuation[1][2].

HY-109523S

Cerivastatin-d3 sodium

Cerivastatin-d₃ sodium is deuterated labeled Cerivastatin sodium (HY-109523). Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect .

Cat. No.	Product Name		Classification

HY-14373

CB30865 ZM 242421		Alkynes
CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC₅₀ values in the 1-10 nM range) . CB30865 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605

Rasagiline mesylate Maximum Cited Publications 6 Publications Verification (R)-AGN1135 mesylate; TVP1012 mesylate		Alkynes
Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605A

Rasagiline Maximum Cited Publications 6 Publications Verification (R)-AGN1135; TVP1012		Alkynes
Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139659

ARD-61		PROTAC Synthesis
ARD-61 is a highly potent, effective and specific PROTAC androgen receptor (AR) degrader. ARD-61 potently and effectively induces AR and progesterone receptors (PR) degradation in AR+ cancer cell lines. ARD-61 induces apoptosis and effectively induces tumor growth inhibition in the MDA-MB-453 xenograft model in mice . ARD-61 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14200

(S)-Rasagiline 1 Publications Verification TVP1022; S-PAI		Alkynes
(S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. Rasagiline is a highly potent selective irreversible MAO inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . (S)-Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605BS

Rasagiline-13C3 mesylate racemic AGN1135-¹³C₃; TVP1012-¹³C₃ racemic		Alkynes
Rasagiline- ¹³C₃ (mesylate racemic) is a ¹³C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor[1]. Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-104066

Theliatinib Xiliertinib; HMPL-309		Alkynes
Theliatinib (Xiliertinib) is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a K_i of 0.05 nM and an IC₅₀ of 3 nM. Theliatinib has an IC₅₀ of 22 nM for EGFR T790M/L858R mutant. Theliatinib shows >50-fold selectivity for EGFR than other kinases . Theliatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-19314

Azvudine 3 Publications Verification RO-0622; FNC		Azide
Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains . Azvudine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-P10680

TFE-IDAtp1-LinA		Azide
TFE-IDAtp1-LinA is a highly potent amphiphilic carrier, containing a trifluoroethyl-iminodiacetic acid analog of Stp. TFE-IDAtp1-LinA, formed nanoparticles with Cas9 RNP/ssDNA, achieved enhanced green fluorescent protein knockouts with an ED₅₀ of 0.38 nM Cas9/sgRNA ribonucleoproteins (RNP) .

HY-104066A

Theliatinib tartrate Xiliertinib tartrate; HMPL-309 tartrate		Alkynes
Theliatinib (Xiliertinib) tartrate is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a K_i of 0.05 nM and an IC₅₀ of 3 nM. Theliatinib has an IC₅₀ of 22 nM for EGFR T790M/L858R mutant. Theliatinib shows >50-fold selectivity for EGFR than other kinases . Theliatinib (tartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-19314A

Azvudine hydrochloride 3 Publications Verification RO-0622 hydrochloride; FNC hydrochloride		Azide
Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains . Azvudine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-133020

ARD-266		PROTAC Synthesis
ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC₅₀ values of 0.2-1 nM . ARD-266 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-107453

SirReal1-O-propargyl PROTAC Sirt2-binding moiety 1		Alkynes
SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC₅₀ of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2 . SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17639

Navamepent RX-10045		Alkynes
Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells. Navamepent is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130985

9-Decyn-1-ol		PROTAC Synthesis Alkynes
9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC₅₀s of 2.0 nM, 6.8 nM and 3.5 nM, respectively . 9-Decyn-1-ol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130654

(S,R,S)-AHPC-C2-PEG4-N3 VH032-C2-PEG4-N3		Azide
(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC₅₀) of 82 nM . (S,R,S)-AHPC-C2-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-145795

OF-02		Cationic Lipids
OF-02 is an alkenyl amino alcohol (AAA) ionizable lipid for highly potent in vivo mRNA delivery.

HY-153785

NH2-C6-ARC186 sodium		Aptamers
NH2-C6-ARC186 sodium is a modified ARC186 (HY-153098) with NH₂-C₆ that can be coupled to other peptides or molecules. ARC186 is a aptamer and a highly potent complement inhibitor that function by blocking the convertase-catalyzed activation of C5 .

HY-19314

Azvudine 3 Publications Verification RO-0622; FNC		Nucleosides and their Analogs
Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains . Azvudine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-19314A

Azvudine hydrochloride 3 Publications Verification RO-0622 hydrochloride; FNC hydrochloride		Nucleosides and their Analogs
Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC₅₀s ranging from 0.03 to 6.92 nM) and HIV-2 (EC₅₀s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains . Azvudine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-153098

ARC186		Aptamers
ARC186 (sodium) is an unconjugated 40KDa PEG aptamer with a sequence identical to HY-147080 Avacincaptad pegol (ARC1905) sodium. ARC1905 is highly potent complement inhibitors that function by blocking the convertase-catalyzed activation of C5.

HY-148695B

ADR58 sodium		Aptamers
ADR58 sodium is a highly potent and selective human oncostatin M (OSM) antagonist, which can prevent the binding of OSM to the gp130 receptor and specifically antagonize OSM-mediated signaling. ADR58 sodium can be used in the research of rheumatoid arthritis related diseases .

HY-148695C

Truncated ADR58 sodium		Aptamers
ADR58 sodium is a highly potent and selective human oncostatin M (OSM) antagonist, which can prevent the binding of OSM to the gp130 receptor and specifically antagonize OSM-mediated signaling. ADR58 sodium can be used in the research of rheumatoid arthritis related diseases .

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