Search Result

Pathways Recommended:	TGF-beta/Smad

Results for "

BETA 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (66) Beta-secretase (3) TGF-beta/Smad (18) TGF-β Receptor (19) 5-HT Receptor (3) ADC Cytotoxin (1) Adrenergic Receptor (155) AIM2 (1) Akt (3) Aldehyde Dehydrogenase (ALDH) (2) Amino Acid Derivatives (1) AMPK (11) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (3) Angiotensin Receptor (1) Antibiotic (7) AP-1 (3) Apoptosis (48) Aurora Kinase (1) Autophagy (24) Bacterial (14) Biochemical Assay Reagents (26) Btk (1) Calcium Channel (6) Caspase (20) Cathepsin (2) CCR (2) Chemerin Receptor (3) Cholinesterase (ChE) (27) COX (14) Cuproptosis (2) Cytochrome P450 (1) Dengue virus (2) Deubiquitinase (2) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (1) Dopamine Receptor (3) Drug Metabolite (1) DYRK (1) E1/E2/E3 Enzyme (1) EGFR (1) Endogenous Metabolite (36) Epigenetic Reader Domain (1) ERK (4) Estrogen Receptor/ERR (3) FAK (3) Ferroptosis (2) FKBP (1) Flavivirus (2) FLT3 (1) Fluorescent Dye (4) Formyl Peptide Receptor (FPR) (1) Free Fatty Acid Receptor (1) Fungal (5) FXR (1) GABA Receptor (8) Glucocorticoid Receptor (3) Glucosylceramide Synthase (GCS) (1) Glutaminase (1) Glutathione Peroxidase (2) Glycosyltransferase (1) GSK-3 (6) HDAC (4) HIF/HIF Prolyl-Hydroxylase (9) Histamine Receptor (2) HIV (2) HIV Protease (1) HSV (2) IFNAR (1) IKK (1) Integrin (64) Interleukin Related (77) IRAK (1) Isotope-Labeled Compounds (27) JAK (1) JNK (3) Keap1-Nrf2 (4) Lactate Dehydrogenase (1) LPL Receptor (1) LXR (2) mAChR (2) MAP4K (1) MDM-2/p53 (1) Mitochondrial Metabolism (1) Mitophagy (4) MMP (4) Monoamine Oxidase (7) mTOR (1) MyD88 (1) Myosin (1) nAChR (5) NADPH Oxidase (2) Neurokinin Receptor (1) NF-κB (23) NO Synthase (12) NOD-like Receptor (NLR) (43) P-glycoprotein (2) P2X Receptor (5) P2Y Receptor (1) p38 MAPK (12) Parasite (4) PD-1/PD-L1 (3) PDGFR (1) PGE synthase (2) Phosphatase (2) Phosphodiesterase (PDE) (3) PI3K (6) PKC (4) Poly(ADP-ribose) Glycohydrolase (PARG) (1) Potassium Channel (4) PPAR (2) PROTACs (1) Protease Activated Receptor (PAR) (2) Proteasome (6) Pyroptosis (6) Raf (1) RAR/RXR (1) Ras (1) Reactive Oxygen Species (8) Renin (3) ROR (1) ROS Kinase (1) SARS-CoV (3) Ser/Thr Protease (3) Smo (1) Sodium Channel (2) Src (2) STAT (3) TAM Receptor (2) Tau Protein (6) TET Protein (1) Thyroid Hormone Receptor (6) TNF Receptor (40) Toll-like Receptor (TLR) (8) Topoisomerase (1) TRP Channel (1) Tyrosinase (3) VD/VDR (1) VEGFR (9) Wnt (1) γ-secretase (2)
By Research Areas:	Cancer (165) Cardiovascular Disease (138) Endocrinology (87) Infection (34) Inflammation/Immunology (272) Metabolic Disease (65) Neurological Disease (160)
Click Chemistry:	Alkynes (3)
Oligonucleotides:	Thickeners (1) Emulsifiers (1) Antisense Oligonucleotides (2)

740

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

122

Natural
Products

131

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Amyloid-β TGF-β Receptor Beta-secretase β-glucuronidase TGF-beta/Smad 17β-HSD β-catenin 11β-HSD Beta-lactamase Dopamine β-hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-152073

*BETA-1*	Fluorescent Dye	Others
BETA-1 is the first twisted intramolecular charge transfer (TICT)-aggregation-induced emission (AIE) integration molecule. BETA-1 emits cyan fluorescence in lipid droplets (LDs) and red fluorescence in mitochondria. BETA-1 can be used for the simultaneous and dual-color imaging of LDs and mitochondria in vivo and in vitro .

HY-E70285

beta-1,4-Galactosyltransferase 1 (Y285L) B4GALT1 (Y285L)	Endogenous Metabolite	Metabolic Disease
beta-1,4-Galactosyltransferase 1 (Y285L) can enzymatic synthesis of the LacdiNAc motif. beta-1,4-Galactosyltransferase 1 (Y285L) can transfer of GalNAc from UDP-GalNAc .

HY-P5542

Vicatertide SB-01	TGF-β Receptor	Inflammation/Immunology
Vicatertide is a TGF beta-1 inhibitor .

HY-E70044

beta-1, 3-N-Acetylhexaminyltransferase (LgtA)	Glycosyltransferase	Metabolic Disease
beta-1, 3-N-Acetylhexaminyltransferase (LgtA) is a glycosyltransferase, is often used in biochemical studies. beta-1, 3-N-Acetylhexaminyltransferase (LgtA) catalyzes the transfer of N-acetylglucosamine from UDP-GlcNAc to N-acetyllactosamine and lactose .

HY-E70054

beta-1,3-Galactosyltransferase (WbgO) CgtB	Others	Others
beta-1,3-Galactosyltransferase (WbgO) (CgtB) acts on N-glycan substrates. beta-1,3-Galactosyltransferase (WbgO) catalyzes the formation of type 1 chains on oligosaccharide, glycopeptide, and glycoprotein substrates, including itself .

HY-118161

1-Adamantylaspartate BETA-1-Adamantylaspartic acid	Others	Others
1-Adamantylaspartate is a newly developed β-β-1-imidopropionic acid used to synthesize the C-terminal octapeptide of the β subunit of human chorionic gonadotropin (hCG) and the hexadecapeptide of the α subunit of the insulin receptor (30-55) by conventional solution methods and solid phase methods, aiming to inhibit the formation of asparagine during the synthesis of asparagyl peptides. Studies have shown that β-β-1-imidopropionic acid is an effective protector of the β-carboxyl function of aspartic acid residues.

HY-E70060

beta-1,4-Galactosyltransferase (LgtE) EB4GALT1 (LgtE)	Others	Others
beta-1,4-Galactosyltransferase (LgtE) (EB4GALT1 (LgtE)) catalyzes the reaction involving UDP-galactose and N-acetylglucosamine for the production of galactose beta-1,4-N-acetylglucosamine .

HY-E70050

beta-1,3-Galactosyltransferase (CgtB) GM1-synthase	Endogenous Metabolite	Others
beta-1,3-Galactosyltransferase (CgtB) (GM1-synthase) is an enzyme that required for sialylated lipooligosaccharide (LOS ^SIAL) production, is often used in biochemical studies. beta-1,3-Galactosyltransferase (CgtB) catalyzes the addition of a galactose molecule, which is required for GM1-like LOS ^SIAL structure production .

HY-E70048

beta-1,3-N-Acetylgalactosaminyltransferase (LgtD) Gb4 synthetase	Others	Others
beta-1,3-N-Acetylgalactosaminyltransferase (LgtD) (Gb4 synthetase) expressed by mature/activated B cells .

HY-E70049

beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) GM2/GD2 synthase	Others	Neurological Disease
beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) (GM2/GD2 synthase) is a key enzyme which catalyzes the conversion of GM3, GD3 and lactosylceramide (LacCer) to GM2, GD2 and asialo-GM2 (GA2), respectively. beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) is a key enzyme to control the synthesis of brain-enriched complex gangliosides .

HY-108790

*Peginterferon beta-1a* Peginterferon β-1a	Apoptosis	Neurological Disease Cancer
Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon beta-1a can be used for the research of cancer and multiple sclerosis (RMS) .

HY-A0275

Amezinium methylsulfate Amezinium metilsulfate; Lu-1631	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake.

HY-B1154

Penbutolol sulfate 1 Publications Verification (-)-Terbuclomine	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Penbutolol sulfate is able to bind to both beta-1 adrenergic receptors and beta-2 adrenergic receptors (the two subtypes), thus making it a non-selective β blocker.

HY-101327

Xamoterol Corwin; ICI 118587	Adrenergic Receptor	Cardiovascular Disease
Xamoterol is a selective and potent agonist of beta1-adrenergic receptor. Xamoterol has the potential for the research of arrhythmogenesis. Xamoterol has the potential for the investigating the relationship between β1-adrenergic stimulation and IKr .

HY-B0381

Betaxolol 4 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Betaxolol is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

HY-B0381A

Betaxolol hydrochloride 4 Publications Verification SL75212	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

HY-100607A

Landiolol hydrochloride ONO1101 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting *beta*-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min)， acts as an adrenoceptor antagonist .

HY-100607

Landiolol ONO1101	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting beta-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min), acts as an adrenoceptor antagonist .

HY-101327A

Xamoterol hemifumarate Corwin hemifumarate; ICI 118587 hemifumarate	Adrenergic Receptor	Cardiovascular Disease
Xamoterol hemifumarate is a selective and potent agonist of beta1-adrenergic receptor. Xamoterol hemifumarate has the potential for the research of arrhythmogenesis. Xamoterol hemifumarate has the potential for the investigating the relationship between β1-adrenergic stimulation and IKr .

HY-156905

6-Azido-N-acetylgalactosamine-UDP	Others	Cancer
6-Azido-N-acetylgalactosamine-UDP (compound 5) is an active sugar donor in the beta-1, 3-N-Acetylhexaminyltransferase (LgtA)-catalyzed glycosylation of lactose .

HY-P2869A

β1-3 Galactosidase	Others	Metabolic Disease
β1-3 Galactosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal β1-3-linked galactose from oligosaccharides and glycoprotein substrates, at a much lower rate, β1-6 linked galactose residues from oligosaccharides .

HY-W145556

Galβ(1-3)GlcNAcβ(1-3)Galβ(1-4)Glc-β-pNP Gal BETA(1-3)GlcNAc BETA(1-3)Gal BETA(1-4)Glc-BETA-pNP	Biochemical Assay Reagents	Others
Galβ(1-3)GlcNAcβ(1-3)Galβ(1-4)Glc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2869C

β1-3,4 Galactosidase	Others	Metabolic Disease
β1-3,4 Galactosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal β1-3 and β1-4 linked galactose residues from oligosaccharides .

HY-P2869E

β1-3,4,6 Galactosidase	Others	Metabolic Disease
β1-3,4,6 Galactosidase is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing β1-3 β1-4 and β1-6 linked galactose residues from oligosaccharides, with β1-6 linked galactose residues at a slower rate .

HY-100607AR

Landiolol hydrochloride (Standard)	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Landiolol (hydrochloride) (Standard) is the analytical standard of Landiolol (hydrochloride). This product is intended for research and analytical applications. Landiolol hydrochloride (ONO1101 hydrochloride) is a highly beta1 selective ultra-short acting *beta*-blocker (β1/β2 selectivity = 255:1, a half-life of 4 min)， acts as an adrenoceptor antagonist .

HY-P2294

pm26TGF-β1 peptide	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-B0381S

Betaxolol-d5	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Betaxolol-d₅ is the deuterium labeled Betaxolol. Betaxolol is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

HY-B0381AS

Betaxolol-d7 hydrochloride SL75212-d₇	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Betaxolol-d₇ (hydrochloride) is the deuterium labeled Betaxolol hydrochloride. Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

HY-P2294A

pm26TGF-β1 peptide TFA 1 Publications Verification	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-P2869D

β1-3,6 Galactosidase, Xanthomonas manihotis	Others	Metabolic Disease
β1-3,6 Galactosidase, Xanthomonas manihotis is a highly specific exoglycosidase that catalyzes the hydrolysis of non-reducing terminal β1-3 and β1-6 linked galactose from complex carbohydrates and glycoproteins .

HY-E70046

β-1,4-Galactosyltransferase, neisseria meningitides	Endogenous Metabolite	Metabolic Disease
beta-1,4-Galactosyltransferase (LgtB) (EC 2.4.1.90) (B4GALT1 (LgtB)) is often used in biochemical studies. beta-1,4-Galactosyltransferase (LgtB) catalyzes the reaction involving UDP-galactose and N-acetylglucosamine for the production of galactose beta-1,4-N-acetylglucosamine .

HY-P2869B

β1-4 Galactosidase, E. coli	Others	Metabolic Disease
β1-4 Galactosidase, E. coli is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing β1-4 linked galactose residues from oligosaccharides .

HY-W145521

β-1,3-Glucan β Glucan	Biochemical Assay Reagents	Others
β-1,3-Glucan is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-N8279

β-1,3-1,4-Glucanase Endo-β-1,3-1,4-glucanase	Others	Metabolic Disease
β-1,3-1,4-Glucanase catalyzes the hydrolysis ofβ-glucan into low molecular weight glucose polymers, thus reducing the hydrophilicity and viscosity of chyme and eliminating the anti-nutritional negative effect. β-1,3-1,4-glucanase can improve feed intake, enhance animal production, regulate cecal microbiota and increase feed conversion ratio .

HY-B0381R

Betaxolol (Standard)	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Betaxolol (Standard) is the analytical standard of Betaxolol. This product is intended for research and analytical applications. Betaxolol is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

HY-B0381AR

Betaxolol hydrochloride (Standard)	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Betaxolol (hydrochloride) (Standard) is the analytical standard of Betaxolol (hydrochloride). This product is intended for research and analytical applications. Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

HY-W145663

Gal-β1,3-GalNAc-β-OMe	Biochemical Assay Reagents	Others
Gal-β1,3-GalNAc-β-OMe is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-48959

α7β1 integrin modulator-1	Integrin	Metabolic Disease
α7β1 integrin modulator-1 is a potent α7β1 integrin modulator. α7β1 integrin modulator-1 has the potential for the research of muscular dystrophy .

HY-139702

α5β1 integrin agonist-1	Integrin	Cancer
α5β1 integrin agonist-1, acting as α5β1 integrin agonist, is able to selectively deliver 5-FU into tumor cells, successfully leading to cancer cell death.

HY-163536

TGF-β1/Smad3-IN-1	TGF-beta/Smad	Inflammation/Immunology
TGF-β1/Smad3-IN-1 (Compound 5aa) is an inhibitor of the *TGF-β1/Smad3* signaling pathway(IC₅₀=1.07 μM). TGF-β1/Smad3-IN-1 possesses antifibrotic activity and oral potency .

HY-157129

AMPK-α1β1γ1 activator 1	AMPK	Cardiovascular Disease
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC₅₀ value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy .

HY-W145539

GlcNAcβ(1-3)[GlcNAcβ(1-6)]GalNAc-α-Thr GlcNAc BETA(1-3)[GlcNAc BETA(1-6)]GalNAc-alpha-Thr	Biochemical Assay Reagents	Others
GlcNAcβ(1-3)[GlcNAcβ(1-6)]GalNAc-α-Thr is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-E70139

*UDP-GalNAc:β-1,3-N-acetylgalactosaminyltransferase 2* EC:2.4.1.313; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase II	Glucosylceramide Synthase (GCS)	Others
UDP-GalNAc:β-1,3-N-acetylgalactosaminyltransferase 2 ( EC:2.4.1.313; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase II) is a glycosyltransferase .

HY-W145558

Galβ(1-4)Glc-β-MP Gal BETA(1-4)Glc-BETA-MP	Biochemical Assay Reagents	Others
Galβ(1-4)Glc-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145607

Galβ(1-3)GalNAc-β-pNP Gal BETA(1-3)GalNAc-BETA-pNP	Biochemical Assay Reagents	Others
Galβ(1-3)GalNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145631

GalNAcβ(1-4)GlcNAc-β-pNP GalNAc BETA(1-4)GlcNAc-BETA-pNP	Biochemical Assay Reagents	Others
GalNAcβ(1-4)GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145594

*Gal[26Bn]β(1-4)Glc[236Bn]-β-MP* Gal[26bn]BETA(1-4)glc[236bn]-BETA-MP	Biochemical Assay Reagents	Others
Gal[26Bn]β(1-4)Glc[236Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W145620

*Gal[246Bn]β(1-4)Glc[236Bn]-β-MP* Gal[246Bn]BETA(1-4)Glc[236Bn]-BETA-MP	Biochemical Assay Reagents	Others
Gal[246Bn]β(1-4)Glc[236Bn]-β-MP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P1868

α2β1 Integrin Ligand Peptide DGEA peptide	Integrin	Infection
α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors .

HY-N6712

Thiolutin 2 Publications Verification Acetopyrrothin	Bacterial Antibiotic Endogenous Metabolite Deubiquitinase	Infection Metabolic Disease
Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36 . Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6712

Thiolutin 2 Publications Verification Acetopyrrothin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Metabolic Disease Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic Endogenous Metabolite Deubiquitinase
Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36 . Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation .

HY-114364

UDP-Galactose disodium	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	P2Y Receptor Endogenous Metabolite
UDP-Galactose disodium is a natural agonist of the P2Y₁₄ receptor with an EC₅₀ of 0.67 μM for the hP2Y₁₄ receptor. UDP-Galactose disodium is a substrate for the transferase beta-1, 4 galactosyltransferase V (B4GALT5). In addition, UDP-Galactose disodium is required for the biosynthesis of several abundant glycoconjugates that form the surface glycocalyx of Leishmania major .

HY-N10634

*D-Glucosyl-β-1,1′-N-palmitoylsphingosine* C16 Glucosyl(β) Ceramide (d18:1/16:0)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Others
D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity .

HY-N2468

Xylobiose 1,4-β-D-Xylobiose; 1,4-D-Xylobiose	Structural Classification Zea mays L. Polysaccharides Classification of Application Fields Gramineae Source classification Other Diseases Plants Disease Research Fields Saccharides	TNF Receptor
Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is a disaccharide of xylose monomers with a β-1, 4 bond between monomers .

HY-108013

Armillarisin A	Monophenols Microorganisms Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Disease Research Fields Inflammation/Immunology	Interleukin Related
Armillarisin A has the potential for the ulcerative colitis (UC) study. Armillarisin A increases IL-4 and lower IL-1β .

HY-N9439

6-O-β-D-Galactopyranosyl-D-galactose	Polysaccharides Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides	Others
6-O-β-D-Galactopyranosyl-D-galactose, a disaccharide, is a part of the polysaccharide main chain with β-(1→6)-glycoside bonds with a side chain bonded to the main one by the β-(1→3) bond .

HY-N3514

Kuwanon E	Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Others
Kuwanon E is a flavonoid isolated from Morus alba, cytotoxic to human monocytic leukemic cell lines, and reduces the level of IL-1β .

HY-N0249

Saikosaponin C	Triterpenes Structural Classification Terpenoids Source classification Umbelliferae Plants Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Amyloid-β
Saikosaponin C is a bioactive component found in radix bupleuri, targets amyloid beta and tau in Alzheimer's disease. Saikosaponin C inhibits the secretion of both Aβ1-40 and Aβ1-42, and suppresses abnormal tau phosphorylation, but shows no effect on BACE1 activity and expression .

HY-N10527

Isoglobotetraose Globoisotetraose	Structural Classification Natural Products Microorganisms	Others
Isoglobotetraose (Globoisotetraose) is the oligosaccharide moiety of human glycosphingolipids. Synthesis process: globotetraose (GalNAcβ1→3Galα1→4Galβ1→4Glc) and isoglobotetraose (GalNAcβ1→3Galα1→3Galβ1→4Glc) .

HY-N8304

Shegansu B (+)-Shegansu B; Parvifolol D	Structural Classification Source classification Gnetum parvifolium (Warb.) C. Y. Cheng ex Chun Phenols Polyphenols Gnetaceae Plants	Interleukin Related
Shegansu B is an inhibitor of *IL-1β. Shegansu B 6 inhibits IL-1*β expression on LPS-induced THP-1 cells with 64.74% inhibition. Shegansu B has anti-inflammatory activity .

HY-17503

Metoprolol 10+ Cited Publications	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor Apoptosis
Metoprolol is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-N1548

Prunasin	Structural Classification Natural Products Classification of Application Fields Source classification Rosaceae Plants Disease Research Fields Amygdalus persica L. Cancer	DNA/RNA Synthesis
Prunasin is a inhibitor of DNA Polymerase β .

HY-108810

Canakinumab Ilaris; ACZ 885	Classification of Application Fields Disease Research Fields Cancer	Interleukin Related
Canakinumab (ACZ885) is a recombinant human *anti-IL-1β* monoclonal antibody. Canakinumab shows IC₅₀ values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin .

HY-N7697B

Chitobiose dihydrochloride	Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides	Others
Chitobiose dihydrochloride, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units .

HY-P99171

Gevokizumab	Classification of Application Fields Disease Research Fields Cancer	Interleukin Related
Gevokizumab is a potent anti-IL-1β antibody, negatively modulates *IL-1β* signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of *IL-1β* for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II) .

HY-N0249R

Saikosaponin C (Standard)	Triterpenes Structural Classification Terpenoids Source classification Umbelliferae Plants Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Amyloid-β
Saikosaponin C (Standard) is the analytical standard of Saikosaponin C. This product is intended for research and analytical applications. Saikosaponin C is a bioactive component found in radix bupleuri, targets amyloid beta and tau in Alzheimer's disease. Saikosaponin C inhibits the secretion of both Aβ1-40 and Aβ1-42, and suppresses abnormal tau phosphorylation, but shows no effect on BACE1 activity and expression .

HY-137782

Palmitoleoyl-CoA	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Biochemical Assay Reagents
Palmitoleoyl-CoA can be activated and transported into the mitochondria for metabolism, specifically for β-oxidation. Palmitoleoyl-CoA induces the cardiac mitochondrial membrane permeability transition, which causes mitochondrial dysfunction. Palmitoleoyl-CoA regulates metabolism via allosteric control of AMPK β1-isoforms .

HY-126996

Triiodothyronine sulfate	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Drug Metabolite Endogenous Metabolite
Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity .

HY-N12837

8-Epiloganin	Castilleja rubra (Drobow) Rebrist. Structural Classification Iridoids Terpenoids Source classification Orobanchaceae Plants	Others
8-Epiloganin can be isolated from Castilleja rubra and has anti-inflammatory properties. 8-Epiloganin inhibits LPS-induced release of pro-inflammatory cytokines, namely tumor necrosis factor-α and interleukin-1β .

HY-N0074

Byakangelicol 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt. Inflammation/Immunology Disease Research Fields	COX
Byakangelicol, isolated from Angelica dahurica, inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of cyclooxygenase-2 (COX-2) expression and the activity of COX-2 enzyme. Byakangelicol has therapeutic potential as an anti-inflammatory agent on airway inflammation .

HY-N0604

Ginsenoside Rh1 2 Publications Verification Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae	Interleukin Related PPAR TNF Receptor Endogenous Metabolite
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and *IL-1β*.

HY-N1125

Triptobenzene H Hypoglic acid	Structural Classification Ketones, Aldehydes, Acids Terpenoids Source classification Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f.	Others
Triptobenzene H (Hypoglic acid) significantly increases TNF-α and IL-1β mRNA levels in macrophages, causing indirect liver damage .

HY-119109

Laminaran	Structural Classification Polysaccharides Microorganisms other families Classification of Application Fields Source classification Plants Disease Research Fields Saccharides Cancer	Others
Laminaran is an *β-1-3-glucan* and a typical ligand for Dectin-1 from Eisenia Bicyclis, has potent immunomodulating, radioprotective, and anticancer activities . Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds . Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy .

HY-N7697F

Chitobiose	Polysaccharides Microorganisms Classification of Application Fields Animals Source classification Other Diseases Disease Research Fields Saccharides	Others
Chitobiose, a chitosan oligosaccharide, is a dimer of β-1,4-linked glucosamine units . Chitobiose has orally activity and high antioxidant activity .

HY-P99708

Livmoniplimab ABBV-151; ARGX-115	Classification of Application Fields Disease Research Fields Cancer	TGF-beta/Smad
Livmoniplimab (ABBV-151) is a monoclonal antibody against *GARP/TGF-β1* that can inhibit the release of active *TGF-β1*. Livmoniplimab has anti-tumor activity in colon cancer mice. Livmoniplimab can be used for the study of locally advanced or metastatic solid tumors .

HY-N1499

Nystose	Structural Classification Polysaccharides Classification of Application Fields Source classification Rubiaceae Metabolic Disease Plants Morinda officinalis How Disease Research Fields Saccharides	Others
Nystose is a tetrasaccharide with two fructose molecules linked via beta (1→2) bonds to the fructosyl moiety of sucrose.

HY-N1147

Tirotundin Tagitinin D	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Tithonia diversifolia A. Gray. Compositae	Others
Tirotundin (Tagitinin D) is a potent anti-inflammatory agent. Tirotundin inhibits the activation of NF-Kβ .

HY-N13262

Dactyllactone A	Structural Classification Alkaloids Microorganisms Source classification Isoquinoline Alkaloids	Interleukin Related
Dactyllactone A is an isoquinoline alkaloid that can be isolated from Dactylicapnos scandens. Dactyllactone A shows anti-inflammatory activity. Dactyllactone A inhibits the expression of IL-1β and PGE2 .

HY-N1876

Aromadendrane-4β,10α-diol	Structural Classification Terpenoids Sesquiterpenes Source classification Hedyosmum brasiliense Mart. Chloranthaceae Plants	Others
Aromadendrane-4β,10α-diol is a sesquiterpene alcohol. Aromadendrane-4β,10α-diol significantly ameliorates the Aβ1-42 peptide-induced memory impairment. Aromadendrane-4β,10α-diol can be used for Alzheimer's disease (AD) research .

HY-P99020

Fresolimumab 1 Publications Verification GC1008	Classification of Application Fields Disease Research Fields Cancer	TGF-β Receptor
Fresolimumab (GC1008) is a high-affinity fully human monoclonal antibody that neutralizes the active form of human TGFβ1, TGFβ2, and TGFβ3. Fresolimumab can be used for the research of cancer and fibrotic diseases .

HY-N3883

Euxanthone	Structural Classification Flavonoids Garcinia oblongifolia Champ. ex Benth. Source classification Guttiferae Plants Other Flavonoids	Autophagy
Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities .

HY-N1431A

Tabersonine hydrochloride	Apocynaceae Alkaloids Structural Classification Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	Amyloid-β
Tabersonine hydrochloride is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and is a potential therapeutic candidate for the treatment of ALI/ARDS .

HY-N1431

Tabersonine 1 Publications Verification	Apocynaceae Alkaloids Structural Classification Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	Amyloid-β
Tabersonine is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and acts as a potential therapeutic candidate for the treatment of ALI/ARDS .

HY-N0042

Ginsenoside Rc Panaxoside Rc	Panax ginseng C. A. Meyer Triterpenes Structural Classification Neurological Disease Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	GABA Receptor TNF Receptor Interleukin Related
Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptor_A (GABA_A)-mediated ion channel currents (I_GABA). Ginsenoside Rc inhibits the expression of TNF-α and *IL-1β*.

HY-112108

Chitosan oligosaccharide 4 Publications Verification COS	Structural Classification Polysaccharides Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Cancer	AMPK Endogenous Metabolite
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.

HY-126414

Methylenedihydrotanshinquinone	Calea platylepis Terpenoids Labiatae Diterpenoids Plants	Others
Methylenedihydrotanshinquinone is a natural product that can be isolated from the dried root of S. miltiorrhiza. Methylenedihydrotanshinquinone has anti-inflammatory effect by inhibiting expression of TNF-α, IL-1β, and IL-8 .

HY-N2587

Irigenin	Structural Classification Flavonoids Iridaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Isoflavones Cancer	Integrin Apoptosis
Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking *α9β1* and *α4β1* integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells .

HY-130778

N,N'-Diacetylchitobiose	Structural Classification Microorganisms Animals Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides	Endogenous Metabolite
N,N'-Diacetylchitobiose is a dimer of β(1,4) linked N-acetyl-D glucosamine. N,N'-Diacetylchitobiose is the hydrolysate of chitin and can be used as alternative carbon source by E. coli .

HY-141488

Lacto-N-biose I Galβ1-3GlcNAc	Polysaccharides Microorganisms Classification of Application Fields Source classification Disease Research Fields Saccharides Endocrinology	Endogenous Metabolite
Lacto-N-biose I (Galβ1-3GlcNAc), as an endogenous metabolite, is an acceptor for the α1,2-fucosyltransferase enzyme from Helicobacter pylori .

HY-P99333

Volociximab M200; Eos 200-4	Classification of Application Fields Disease Research Fields Cancer	Integrin
Volociximab (M200) is a chimeric human/murine IgG4 antibody IIA1 targeting integrin α5β1 (EC₅₀=0.2 nM). Integrin α5β1 is a major fibronectin receptor involved in angiogenesis. Volociximab has antiangiogenic and antitumor activities and inhibits the proliferation of human umbilical vein vascular endothelial cells (HUVECs) .

HY-126114

Lupeol acetate 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Umbelliferae Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	COX Interleukin Related
Lupeol acetate, a derivative of Lupeol, suppresses the progression of rheumatoid arthritis (RA) by inhibiting the activation of macrophages and osteoclastogenesis through downregulations of TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B .

HY-17462

Adrenosterone (+)-Adrenosterone	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Androgen Receptor Endogenous Metabolite
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-N2509

Iristectorigenin B Iristectrigenin B	Cardiovascular Disease Natural Products Iridaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields	LXR
Iristectorigenin B (Iristectrigenin B) is a liver X receptor (LXR) modulator. Iristectrigenin B stimulates the transcriptional activity of both LXR-α and LXR-β .

HY-163777

Talaroterphenyl A	Structural Classification Monophenols Microorganisms Source classification Phenols	Phosphodiesterase (PDE)
Talaroterphenyl A (compound 1) is a p-terphenyl derivative present in the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41412, which exhibits phosphodiesterase 4 (PDE4) inhibitory activity (IC₅₀=1.2 μM). Talaroterphenyl A also exhibits anti-inflammatory and anti-fibrotic activities, significantly reducing the mRNA levels of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β .

HY-N0506

Rosarin	Structural Classification Simple Phenylpropanols Rhodiola rosea Linn. Crassulaceae Source classification Phenylpropanoids Plants	Interleukin Related
Rosarin is a cinnamyl alcohol?glycoside isolated from?Rhodiola rosea. Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1?β, and TNF- α in the kidney and prefrontal cortex of brain in mice? .

HY-P1189

Echistatin	Structural Classification Natural Products Animals Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Integrin
Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of α_IIbβ₃, α_vβ₃ and *α₅β₁* .

HY-P1189A

Echistatin TFA	Structural Classification Natural Products Animals Classification of Application Fields Source classification Metabolic Disease Inflammation/Immunology Disease Research Fields	Integrin
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of α_IIbβ₃, α_vβ₃ and *α₅β₁* .

HY-N1915

Cellohexaose	Structural Classification Natural Products Polysaccharides Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides	Endogenous Metabolite
Cellohexaose is a glucose polymer with two or more glucose monomers produced from the breakdown of cellulose, consisting of a condensation of beta (1-4) linked D-glucose monomers .

HY-N0602

Ginsenoside Rg2 2 Publications Verification Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Structural Classification Neurological Disease Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	NF-κB Amyloid-β
Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ_1-42 accumulation.

HY-N0651

Spinosin	Structural Classification Flavonoids Flavones Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H.F.Chow. Source classification Phenols Polyphenols Plants Rhamnaceae	Amyloid-β
Spinosyn is a kind of effective C-saccharide, which has a protective effect. Spinosyn is active through Nrf2/HO-1 pathway inhibition Aβ_1-42's production and combination .

Cat. No.	Product Name	Chemical Structure

HY-17498S

Atenolol-d7
Atenolol-d₇ is the deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris[1][2].

HY-B0381S

Betaxolol-d5
Betaxolol-d₅ is the deuterium labeled Betaxolol. Betaxolol is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

HY-B0381AS

Betaxolol-d7 hydrochloride
Betaxolol-d₇ (hydrochloride) is the deuterium labeled Betaxolol hydrochloride. Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker that can be used for the research of hypertension and glaucoma.

HY-146764S

*D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine-d7*
D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine.

HY-146766S

*D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine-d7*
D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine.

HY-146761S

3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d7
3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d₇ is deuterium labeled 3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine.

HY-15746S1

(rac)-Dobutamine-d6 hydrochloride

(rac)-Dobutamine-d₆ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion[1][2][3][4].

HY-15746S

(rac)-Dobutamine-d4 hydrochloride

(rac)-Dobutamine-d₄ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion[1][2][3][4].

HY-W752055

(Rac)-Nebivolol-d4 hydrochloride
(Rac)-Nebivolol-d4 hydrochloride is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1-adrenergic receptor with an IC₅₀ of 0.8 nM .

HY-14300AS

Vilanterol-d4 trifenatate
Vilanterol-d₄ (trifenatate) is deuterium labeled Vilanterol (trifenatate). Vilanterol trifenatate (GW642444 trifenatate) is a long-acting β2-adrenoceptor (β2-AR) agonist with inherent 24-hour activity. The pEC50s for β2-AR, β1-AR and β3-AR are 10.37, 6.98 and 7.36, respectively.

HY-129029S

Bisoprolol-d5
Bisoprolol-d₅ is the deuterium labeled Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research[1][2].

HY-119802S

Practolol-d7
Practolol-d₇ is the deuterium labeled Practolol. Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias[1][2][3].

HY-17503AS

Metoprolol-d7 hydrochloride
Metoprolol-d₇ (hydrochloride) is the deuterium labeled Metoprolol. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3][4].

HY-17503S3

Metoprolol-d5
Metoprolol-d₅ is the deuterium labeled Metoprolol[1]. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties[2][3][4].

HY-17503BS

Metoprolol-d6 tartrate
Metoprolol-d₆ (tartrate) is the deuterium labeled Metoprolol tartrate. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3][4].

HY-108286S

(Rac)-Talinolol-d5
(Rac)-Talinolol-d₅ is the racemate of Talinolol. Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity[1][2][3].

HY-B0076S

Bisoprolol-d7 hemifumarate
Bisoprolol-d₇ (hemifumarate) is the deuterium labeled Bisoprolol hemifumarate. Bisoprolol hemifumarate is a selective type β1 adrenergic receptor blocker.

HY-135119

Salmeterol-d3
Salmeterol-d₃ is a deuterium labeled Salmeterol. Salmeterol is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].

HY-14302S1

Salmeterol-d5
Salmeterol-d5 is a deuterated labeled Salmeterol . Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-100935S

Cimaterol-d7
Cimaterol-d₇ is the deuterium labeled Cimaterol. Cimaterol is a potent agonist of β-adrenergic receptors (pEC50s=8.13, 8.78, and 6.62 for human β1, β2, and β3, respectively). Cimaterol has been used in farmed animals to increase carcass mass and to alter muscle and fat deposition.

HY-17453S

Salmeterol-d3 xinafoate
Salmeterol-d₃ (xinafoate) is the deuterium labeled Salmeterol xinafoate. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].

HY-17453S1

Salmeterol-13C6 xinafoate
Salmeterol- ¹³C₆ (xinafoate) is the ¹³C₆ labeled Salmeterol (xinafoate). Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.

HY-B0203BS1

(rac)-Nebivolol-d4
(rac)-Nebivolol-d₄ is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM[1][2].

HY-17497S

Acebutolol-d7
Acebutolol-d₇ is a deuterium labeled Acebutolol. Acebutolol is a selective β1 adrenergic receptor antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias[1].

HY-B0203BS2

(Rac)-Nebivolol-d2,15N

(Rac)-Nebivolol-d₂, ¹⁵N is ¹⁵N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .

HY-17503S

Metoprolol-d7
Metoprolol-d₇ is the deuterium labeled Metoprolol. Metoprolol (Toprol) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension[1][2].

HY-17503S2

(S)-Metoprolol-d7
(S)-Metoprolol-d₇ is the deuterium labeled Metoprolol. Metoprolol (Toprol) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension[1][2].

HY-17503S1

(R)-Metoprolol-d7
(R)-Metoprolol-d₇ is the deuterium labeled Metoprolol. Metoprolol (Toprol) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension[1][2].

HY-100634S

4-Hydroxypropranolol-d7 hydrochloride

4-Hydroxypropranolol-d₇ (hydrochloride) is a deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol, with potency comparable to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties[1][2][3].

HY-19717S

DCVC-13C3,15N
DCVC- ¹³C₃, ¹⁵N is ¹⁵N and ¹³C labeled DCVC. DCVC (S-[(1E)-1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures .

HY-B0573BS

Propranolol-d7

Propranolol-d₇ is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

HY-100634SA

4-Hydroxypropranolol-d7

4-Hydroxypropranolol-d₇ is the deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol. 4-Hydroxypropranolol hydrochlorid is of comparable potency to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties[1][2][3].

HY-B0573S

Propranolol-d7 hydrochloride

Propranolol-d₇ (hydrochloride) is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

HY-128423AS

Tylvalosin-d9
Tylvalosin-d₉ (Acetylisovaleryltylo?sin-d₉)is the deuterium labeledTylvalosin(HY-128423A) . Tylvalosin is a third-generation macrolide, with anti-inflammatory property. Tylvalosin decreases the levels of IL-8, IL-6, IL-1β, PGE2, TNF-α and NO, and reduces the inflammatory cells recruitment and activation in mouse acute lung injury model .

HY-B0573S1

Propranolol-d7 (ring-d7)

Propranolol-d₇ (ring-d₇) is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

HY-13715S

(Rac)-Norepinephrine-d3 formate
(Rac)-Norepinephrine-d₃ (formate) is deuterium labeled Norepinephrine. Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors[1][2][3][4].

HY-N7142S

DL-Norepinephrine-d6 hydrochloride
DL-Norepinephrine-d₆ (hydrochloride) is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine．DL-Norepinephrine hydrochloride is a neurotransmitter targets α1 and β1 adrenoceptors, has an increasing effect on subendocardial oxygen tension[1].

HY-N7142S1

DL-Norepinephrine-d3 hydrochloride
DL-Norepinephrine-d₃ (hydrochloride) is the deuterium labeled DL-Norepinephrine hydrochloride[1]. DL-Norepinephrine hydrochloride is a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine．DL-Norepinephrine hydrochloride is a neurotransmitter targets α1 and β1 adrenoceptors, has an increasing effect on subendocardial oxygen tension[2].

HY-W758126

(R)-Brivanib alaninate-d4
(R)-Brivanib alaninate-d₄ is the deuterium-labeled Brivanib (alaninate) (HY-10336). Brivanib alaninate (BMS-582664) is an ATP-competitive inhibitor against VEGFR2 with an IC₅₀ of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ .

HY-12753AS

Debutyldronedarone-d7 hydrochloride

Debutyldronedarone-d₇ hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α₁ (TRα₁) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα₁ and TRβ₁ by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic .

HY-123489S

3α,21-Dihydroxy-5α-pregnan-20-one-d3
3α,21-Dihydroxy-5α-pregnan-20-one-d₃ is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks