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PA N-oxide,hepatocarcinogenic,pyrrolizidine alkaloid

" in MedChemExpress (MCE) Product Catalog:

1445

Inhibitors & Agonists

11

Screening Libraries

2

Fluorescent Dye

17

Biochemical Assay Reagents

24

Peptides

3

Inhibitory Antibodies

1099

Natural
Products

21

Recombinant Proteins

60

Isotope-Labeled Compounds

5

Antibodies

4

Click Chemistry

9

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-112544
    IK1 inhibitor PA-6
    1 Publications Verification

    PA-6

    		 Potassium Channel Cardiovascular Disease
    IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia .
    IK1 inhibitor PA-6
  • HY-P10352A
    Pediocin PA 1 TFA

    		Bacterial Infection
    Pediocin PA-1 TFA is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 TFA can be used as a food biopreservative .
    Pediocin PA 1 TFA
  • HY-129421
    PA-9

    		PACAP Receptor Neurological Disease Inflammation/Immunology
    PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC50 of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain .
    PA-9
  • HY-10844
    Pretomanid
    5+ Cited Publications

    PA-824; (S)-PA 824

    		 Bacterial Antibiotic Infection Cancer
    Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.
    Pretomanid
  • HY-133529
    PA-8

    		PACAP Receptor Neurological Disease Inflammation/Immunology
    PA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in PAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC50 of 2 nM .
    PA-8
  • HY-133590
    Heliotrine N-oxide

    		DNA Alkylator/Crosslinker Cancer
    Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128). Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo .
    Heliotrine N-oxide
  • HY-N1099
    Vellosimine

    (+)-Vellosimine; alkaloid RB 19

    		 Others Others
    Vellosimine ((+)-Vellosimine) is an indole alkaloid. Vellosimine acts as a plant metabolite .
    Vellosimine
  • HY-N9130
    Indicine

    		Others Others
    Indicine (Compound 3) is an alkaloid. Indicine can reduce pyrrolizine alkaloids (PA) .
    Indicine
  • HY-P10352
    Pediocin PA 1

    		Bacterial Infection
    Pediocin PA-1 is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 can be used as a food biopreservative .
    Pediocin PA 1
  • HY-103495
    17-PA

    		GABA Receptor Neurological Disease
    17-PA is a selective antagonist of neurosteroid potentiation and direct gating of GABA A receptors .
    17-PA
  • HY-144767
    PA3552-IN-1

    		Bacterial Infection
    PA3552-IN-1 (compound 15) is an antibiotic adjuvant that restores sensitivity of MDR P. aeruginosa DK2 strain to Polymyxin B. PA3552-IN-1 can reduce PA3552 expression .
    PA3552-IN-1
  • HY-125667
    PA1

    Photoamiloride-1

    		 Sodium Channel Metabolic Disease
    PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively .
    PA1
  • HY-P5981
    Chromozym t-PA

    		Biochemical Assay Reagents Others
    Chromozym t-PA can be used for determination of t-PA (tissue plasminogen activator) concentration
    Chromozym t-PA
  • HY-155684
    SA-PA

    		PROTACs VEGFR PDGFR Ephrin Receptor Cancer
    SA-PA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-PA is able to selectively degrade VEGFR-2, PDGFR-β and EphB4 proteins in U87 cells. SA-PA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues .
    SA-PA
  • HY-149594
    CL-Pa

    		Pantetheinase Metabolic Disease
    CL-Pa is a chemiluminescent probe suitable for detection of urinary Vanin-1. CL-Pa can be used to detect drug-induced acute kidney injury (AKI) through urinalysis .
    CL-Pa
  • HY-167600AS
    18:0 PA-d70

    		Isotope-Labeled Compounds Others
    18:0 PA-d70 is deuterium labeled 18:0 PA0 .
    18:0 PA-d70
  • HY-113845
    (+)-Intermedine

    		Others Neurological Disease
    (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .
    (+)-Intermedine
  • HY-112789
    (+)-JQ1 PA
    1 Publications Verification

    		 Epigenetic Reader Domain Cancer
    (+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM. (+)-JQ1 PA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (+)-JQ1 PA
  • HY-P5478
    Influenza virus PA (46-54)

    		DNA/RNA Synthesis Influenza Virus Others
    Influenza virus PA (46-54) is a biological active peptide. (HLA-A*0201 restricted epitope from influenza virus RNA polymerase subunit, PA (46-54).)
    Influenza virus PA (46-54)
  • HY-133535
    PA Janelia Fluor® 646, SE

    PA-JF646-NHS

    		 Fluorescent Dye Others
    PA Janelia Fluor® 646, SE (PA-JF646-NHS), a photoactivatable fluorescent dye, is an NHS ester for coupling to primary amine groups. PA-JF646-NHS is non-fluorescent until activated at 365 nm. NHS ester can be converted to relevant substrate for use in self-labeling tag systems, e.g.HaloTag ® and SNAP-tag ®. PA-JF646-NHS is used for single molecule tracking and super resolution microscopy in live cells, specifically live cell sptPALM and fixed cell PALM. (λExcitation/emission~650/664 nm). Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
    PA Janelia Fluor® 646, SE
  • HY-157639A
    18:2 Lyso PA sodium

    		Others Cardiovascular Disease
    18:2 Lyso PA sodium is an unsaturated lysophosphatidic acid (LysoPA), a lipid mediator mainly present in plasma and thought to be involved in the pathogenesis of acute coronary syndrome (ACS). 18:2 Lyso PA sodium significantly correlates with serum autotaxin (ATX) in peripheral arteries .
    18:2 Lyso PA sodium
  • HY-146896S
    16:0-18:1 PA-d31 sodium

    		Isotope-Labeled Compounds Others
    16:0-18:1 PA-d31 (sodium) is deuterium labeled 16:0-18:1 PA (sodium).
    16:0-18:1 PA-d31 sodium
  • HY-10844S1
    Pretomanid-d5

    PA-824-d5; (S)-PA 824-d5

    		 Antibiotic Bacterial Isotope-Labeled Compounds Infection Cancer
    Pretomanid-d5 is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.
    Pretomanid-d5
  • HY-166982
    DSPE-PEG-PA (MW 2000)

    		Biochemical Assay Reagents Others
    DSPE-PEG-PA (MW 2000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. DSPE-PEG-PA (MW 2000) can be used in drug delivery research .
    DSPE-PEG-PA (MW 2000)
  • HY-124058
    Jacobine

    		Insecticide Others
    Jacobine?is a pyrrolizidine alkaloid (PA) from Senecio jacobaea . Jacobine is active against second instar larvae of thrips .
    Jacobine
  • HY-P10827
    PIC1 PA

    		Complement System Inflammation/Immunology
    PIC1 PA, a 15 amino-acid peptide, is a potent PIC1 analog that inhibits classical pathway mediated complement activation. PIC1 PA functionally disrupts the C1s-C1r-C1r-C1s/MASPs interaction with collagen-like region (CLR) of C1q/MBL, respectively. PIC1 PA specifically binds to the CLR of C1q and bounds to purified C1q with a mean equilibrium dissociation constant (KD) of 33.3 nM .
    PIC1 PA
  • HY-133534
    PA-Nic TFA

    		Photosensitizer nAChR Others
    PA-Nic TFA is a photoactivatable nicotine, whcih can be photolyzed with ~405 nm laser flashes to efficiently release nicotine .
    PA-Nic TFA
  • HY-N11652
    6α-Hydroxylycopodine

    alkaloid L20

    		 Others Others
    6α-Hydroxylycopodine (Alkaloid L20) is a Flavonoids product that can be isolated from the herbs of Crotalaria barbata .
    6α-Hydroxylycopodine
  • HY-108522
    PA452
    1 Publications Verification

    		 RAR/RXR Metabolic Disease
    PA452, retinoic X receptor (RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development .
    PA452
  • HY-147067
    16:0-18:2 PA sodium

    		Biochemical Assay Reagents
    16:0-18:2 PA (sodium) is a biochemical reagent .
    16:0-18:2 PA sodium
  • HY-N6638
    Retrorsine
    1 Publications Verification

    		 Others Metabolic Disease
    Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury .
    Retrorsine
  • HY-166992
    1,2-Dioleoyl-sn-glycero-3-PA ammonium

    		Biochemical Assay Reagents Others
    1,2-Dioleoyl-sn-glycero-3-PA (ammonium) is a phospholipid. Phospholipids have good biocompatibility and significant amphiphilic characteristics, making them the main and suitable dosage form or excipient in drug formulations, thereby achieving better therapeutic effects. 1,2-Dioleoyl-sn-glycero-3-PA (ammonium)can be used in drug delivery research .
    1,2-Dioleoyl-sn-glycero-3-PA ammonium
  • HY-P1580
    PA (224-233), Influenza

    		Influenza Virus Infection
    PA (224-233), Influenza is a 10-aa peptide, a fragment of polymerase 2 protein in influenza A virus.
    PA (224-233), Influenza
  • HY-N6638R
    Retrorsine (Standard)

    		Others Metabolic Disease
    Retrorsine (Standard) is the analytical standard of Retrorsine. This product is intended for research and analytical applications. Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury .
    Retrorsine (Standard)
  • HY-113845R
    (+)-Intermedine (Standard)

    		Others Neurological Disease
    (+)-Intermedine (Standard) is the analytical standard of (+)-Intermedine. This product is intended for research and analytical applications. (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .
    (+)-Intermedine (Standard)
  • HY-133536
    PA Janelia Fluor® 549, SE

    PA-JF549-NHS

    		 Fluorescent Dye Others
    PA Janelia Fluor 549, SE (PA-JF549-NHS) is a bright photoactivatable fluorophore of JF549,SE (JF549,NHS). JF549,SE (JF549,NHS) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
    PA Janelia Fluor® 549, SE
  • HY-129968
    AM-Imidazole-PA-Boc

    		PROTAC Linkers Cancer
    AM-Imidazole-PA-Boc is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC IRAK4 degrader-1 (HY-129966) .
    AM-Imidazole-PA-Boc
  • HY-132141
    5-PA-dUTP

    5-ProPArgylamino-dUTP

    		 DNA/RNA Synthesis Others
    5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery . 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    5-PA-dUTP
  • HY-19160
    BMS-180680

    PA-1806; BMS 180680-01

    		 Antibiotic Bacterial Infection
    BMS-180680 (PA-1806) is an antibiotic, which exhibits a board-spectrum antibacterial activity against gram-negative bacteria. BMS-180680 inihibits Pseudomonas aeruginosa with MIC of 0.25 µg/ml. BMS-180680 exhibits resistance to hydrolysis by β-lactamases, such as TEM-2 and PSE enzymes .
    BMS-180680
  • HY-RS09947
    PA2G4 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PA2G4 Human Pre-designed siRNA Set A contains three designed siRNAs for PA2G4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PA2G4 Human Pre-designed siRNA Set A
    PA2G4 Human Pre-designed siRNA Set A
  • HY-157045
    ATP Synthesis-IN-1

    		ATP Synthase Infection
    ATP Synthesis-IN-1 (Compound 4), quinoline derivative, is a potent inhibitor of PA ATP synthesis activity. ATP Synthesis-IN-1 has PA ATP synthesis inhibition with IC50 value of 11.1μg/mL. ATP Synthesis-IN-1 also has antibacterial activity. ATP Synthesis-IN-1 can be used for the research of drug-resistant PA infection .
    ATP Synthesis-IN-1
  • HY-131574
    Heliosupine N-oxide

    		mAChR Neurological Disease
    Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC50 of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .
    Heliosupine N-oxide
  • HY-N0842
    Bevirimat
    1 Publications Verification

    PA-457; MPC-4326; YK FH312

    		 Virus Protease Infection
    Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies .
    Bevirimat
  • HY-111915
    1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt
    1 Publications Verification

    18:1 PA

    		 Liposome Others
    1,2-Dioleoyl-sn-glycero-3-phosphate sodium salt (18:1 PA) is an anionic lipid that can be used to prepare liposomes, micelles and artificial membranes .
    1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt
  • HY-41919
    Mal-L-PA-NH-Boc

    mDPR(boc); (S)-MALEOYL-DPR(BOC)-OH·DCHA

    		 ADC Linker Cancer
    Mal-L-PA-NH-Boc is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Mal-L-PA-NH-Boc
  • HY-W783254
    C18 LPA

    PA(18:0e/0:0)

    		 G Protein-coupled Receptor Kinase (GRK) Calcium Channel Cardiovascular Disease Cancer
    C18 LPA (PA(18:0e/0:0)) is a water-soluble phospholipid that functions as a signaling molecule, influencing various cellular responses through G protein-coupled receptors (GPCRs). It is known to promote smooth muscle contraction, cytoskeletal rearrangement, and chemotaxis, while also playing a role in neurotransmitter release, cell proliferation, platelet aggregation, and Ca2+ mobilization. Elevated levels of C18 LPA in human plasma are associated with ovarian cancer and atherosclerosis, suggesting its potential as a biomarker for ovarian cancer.
    C18 LPA
  • HY-W339758
    10:0 PA sodium

    1,2-Didecanoyl-sn-glycero-3-phosphate sodium

    		 Biochemical Assay Reagents Others
    10:0 PA (1,2-Didecanoyl-sn-glycero-3-phosphate) sodium is an anionic lipid that can be used to prepare nanoemulsions to improve the oral bioavailability of Etoposide (HY-13629) .
    10:0 PA sodium
  • HY-W725309
    18:0-18:1 PA sodium

    1-Stearoyl-2-oleoyl-sn-glycero-3-phosphate sodium

    		 Biochemical Assay Reagents Others
    18:0-18:1 PA (1-Stearoyl-2-oleoyl-sn-glycero-3-phosphate) sodium is an anionic lipid .
    18:0-18:1 PA sodium
  • HY-B2193C
    α-Amylase, Porcine Pancreatic

    1,4-alpha-D-Glucan-glucanohydrolase, amy2, PPA, PA

    		 Amylases Others
    α-Amylase, Porcine Pancreatic (1,4-alpha-D-Glucan-glucanohydrolase, amy2, PPA, PA) is a biological material or organic compound that can be used in life science research .
    α-Amylase, Porcine Pancreatic
  • HY-N1633
    1-Methoxycarbonyl-β-carboline

    		Others Others
    1-Methoxycarbonyl-β-carboline is a natural alkaloid .
    1-Methoxycarbonyl-β-carboline

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