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leukemia,

" in MedChemExpress (MCE) Product Catalog:

By Targets:	BMI1 (1) 5-HT Receptor (1) ADC Antibody (4) ADC Cytotoxin (15) Adenosine Receptor (2) Akt (7) Aldose Reductase (2) Amino Acid Derivatives (2) Aminopeptidase (1) AMPK (5) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (41) Antibody-Drug Conjugates (ADCs) (1) Antifolate (12) Apoptosis (241) Arenavirus (1) ATP-binding cassette (ABC) transporters (1) Aurora Kinase (7) Autophagy (24) Bacterial (47) Bcl-2 Family (42) Bcr-Abl (37) Beta-lactamase (1) Biochemical Assay Reagents (5) Btk (11) c-Fms (1) c-Kit (10) c-Met/HGFR (1) c-Myc (5) Calcium Channel (2) Calmodulin (1) Carbonic Anhydrase (1) Casein Kinase (6) Caspase (9) CCR (2) CD19 (2) CD22 (1) CD3 (1) CDK (23) Ceramidase (1) Checkpoint Kinase (Chk) (2) ClpP (1) COX (3) Cuproptosis (1) CXCR (6) Cytochrome P450 (2) Deubiquitinase (5) Dihydrofolate reductase (DHFR) (3) Dihydroorotate Dehydrogenase (9) DNA Alkylator/Crosslinker (10) DNA Methyltransferase (8) DNA/RNA Synthesis (45) Drug Derivative (8) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (5) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (7) E3 Ligase Ligand-Linker Conjugates (2) EGFR (2) Endogenous Metabolite (34) Epigenetic Reader Domain (51) ERK (2) Estrogen Receptor/ERR (2) Eukaryotic Initiation Factor (eIF) (2) Farnesyl Transferase (2) Ferroptosis (1) FGFR (6) FLT3 (81) Fluorescent Dye (4) Fungal (6) G protein-coupled Bile Acid Receptor 1 (1) G-quadruplex (1) Galectin (1) Glucocorticoid Receptor (1) Glucosylceramide Synthase (GCS) (1) GSK-3 (7) HDAC (32) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (3) Histone Acetyltransferase (3) Histone Demethylase (22) Histone Methyltransferase (18) HIV (7) HSP (4) HSV (5) IFNAR (3) IKK (1) Influenza Virus (1) Insecticide (1) Insulin Receptor (1) Integrin (4) Interleukin Related (8) IRAK (3) Isocitrate Dehydrogenase (IDH) (8) Isotope-Labeled Compounds (10) Itk (1) JAK (14) JNK (3) Keap1-Nrf2 (1) Kinesin (1) KLF (1) LAG-3 (1) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (5) Lipoxygenase (3) LPL Receptor (1) LXR (1) MAP4K (1) MARK (2) MDM-2/p53 (14) MEK (1) MicroRNA (1) Microtubule/Tubulin (7) Mitochondrial Metabolism (4) Mitophagy (2) MMP (2) MNK (3) Molecular Glues (6) Monoamine Oxidase (3) Mps1 (2) mTOR (2) NF-κB (7) NO Synthase (1) Notch (2) Nuclear Factor of activated T Cells (NFAT) (1) Nucleoside Antimetabolite/Analog (6) Orthopoxvirus (3) Oxidative Phosphorylation (3) P-glycoprotein (9) p38 MAPK (8) p97 (1) Parasite (5) PARP (2) PD-1/PD-L1 (1) PDGFR (12) PDHK (1) PERK (3) Phosphatase (5) Phospholipase (1) Photosensitizer (1) PI3K (15) Pim (5) PKA (2) PKC (3) Polo-like Kinase (PLK) (2) Potassium Channel (2) PPAR (1) Prostaglandin Receptor (2) PROTACs (42) Proteasome (3) Pyroptosis (1) Raf (1) RANKL/RANK (1) Ras (3) Reactive Oxygen Species (9) RET (4) Reverse Transcriptase (3) Ribosomal S6 Kinase (RSK) (1) RUNX (1) Salt-inducible Kinase (SIK) (2) SARS-CoV (4) Scavenger Receptor Class B type I (SR-BI） (1) Ser/Thr Kinase (1) Ser/Thr Protease (2) SF3B1 (2) SHMT (1) Sirtuin (5) SphK (3) Src (9) STAT (24) Syk (6) TAM Receptor (3) TET Protein (2) Thymidylate Synthase (1) Tie (1) Tim3 (1) TMV (1) TNF Receptor (8) Topoisomerase (13) Transferrin Receptor (1) Transmembrane Glycoprotein (2) Trk Receptor (2) VEGFR (5) WDR5 (11) Wnt (2) Xanthine Oxidase (1) β-catenin (1)
By Research Areas:	Cancer (762) Cardiovascular Disease (12) Endocrinology (2) Infection (82) Inflammation/Immunology (74) Metabolic Disease (13) Neurological Disease (21)
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Targets Recommended: BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136175

Revumenib 5+ Cited Publications SNDX-5613	Epigenetic Reader Domain	Cancer
Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding K_i of 0.149 nM and a cell based IC₅₀ of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) .

HY-162350

TDI-11055	Endogenous Metabolite	Cancer
TDI-11055 is an inhibitor of the epigenetic reader protein 11-19 leukemia (ENL) YEATS, which drives the oncogenic transcriptional program of acute myeloid leukemia (AML), the hematopoietic malignancy AML .

HY-E70085

*Moloney murine leukemia* virus RT**	DNA/RNA Synthesis	Infection
Moloney murine leukemia virus RT is a monomeric reverse transcriptase from Moloney murine leukemia virus (MMLV). Moloney murine leukemia virus RT is a replicative polymerase that play an essential role in the life cycle of the retrovirus .

HY-152470

*Eleven-Nineteen-Leukemia* Protein IN-2**	Epigenetic Reader Domain	Cancer
Eleven-Nineteen-Leukemia Protein IN-2 (compound 23) is an Eleven-Nineteen-Leukemia Protein (ENL) inhibitor with an IC₅₀ value of 10.7 nM. Eleven-Nineteen-Leukemia Protein IN-2 can be used for the research of leukemia .

HY-152469

*Eleven-Nineteen-Leukemia* Protein IN-1**	Epigenetic Reader Domain	Cancer
Eleven-Nineteen-Leukemia Protein IN-1 is an inhibitor of ENL YEATS domain with an IC₅₀ value of 14.5 nM. Eleven-Nineteen-Leukemia Protein IN-1 interacts with ENL protein and enhances the thermal stability of ENL protein in vitro .

HY-152471

*Eleven-Nineteen-Leukemia* Protein IN-3**	Epigenetic Reader Domain	Cancer
Eleven-Nineteen-Leukemia Protein IN-3 is an orally active inhibitor of ENL YEATS domain with an IC₅₀ value of 15.4 nM. Eleven-Nineteen-Leukemia Protein IN-3 down-regulates MYC expression through ENL in cells and can enhances the thermal stability of ENL protein in vitro .

HY-12625

MIV-6	Epigenetic Reader Domain	Others
MIV-6 is a small molecule inhibitor that inhibits menin-mixed lineage leukemia (MLL) interaction and exhibits strong selective activity in MLL leukemia cells with IC₅₀ = 56 nM.

HY-150507

JNJ-4355	Bcl-2 Family	Cancer
JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with K_I of 18 pM. JNJ-4355 shows antitumor activity .

HY-N10206

11-epi-Chaetomugilin I	Endogenous Metabolite	Cancer
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

HY-154961

Mcl-1 inhibitor 14	Bcl-2 Family	Cancer
Mcl-1 inhibitor 14 (Compound (Ra)-10) is an inhibitor of *myeloid cell leukemia-1 (MCL-1)* with an K_i of 0.018 nM and can be used for anticancer research .

HY-128607

Mcl1-IN-9	Bcl-2 Family	Cancer
Mcl1-IN-9 is a potent *myeloid cell leukemia-1 (Mcl-1)* Inhibitor with an IC₅₀ of 446 nM in reengineered BCR-ABL+ B-ALL cells and a K_i of 0.03 nM .

HY-171146

HSN748	FLT3 Bcr-Abl RET PDGFR MNK	Cancer
HSN748 is a Ponatinib (HY-12047) analogue and a multikinase inhibitor. HSN748 has inhibitory activity on FLT3, ABL1, RET, PDGFRα/β, MNK1, MNK2 and other kinases. HSN748 can inhibit the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines and can be used in the study of leukemia .

HY-P99207

Lenzilumab KB 003	SARS-CoV	Cancer
Lenzilumab (KB 003) is a human monoclonal antibody targeting CSF2/GM-CSF for COVID-19, chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) studies .

HY-122378

Diopterin Pteroyl diglutamic acid; Folate monoglutamate	Antifolate	Cancer
Diopterin is a folic acid analog that is used in leukemia research .

HY-148422

Rohinitib	Eukaryotic Initiation Factor (eIF) Apoptosis	Cancer
Rohinitib is a potent and specific eIF4A inhibitor. Rohinitib induces cell apoptosis of acute myeloid leukemia (AML) cell lines and reduces the leukemia burden of AML xenograft model. Rohinitib can be used for the research of AML .

HY-12625A

MIV-6R	Others	Others
MIV-6R is an optimized small molecule inhibitor of menin-mixed lineage leukemia (MLL) interaction with IC₅₀ = 56 nM, and its specific mechanism of action activity has been validated in MLL leukemia cells.

HY-114410

CCI-006	Mitochondrial Metabolism	Cancer
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells .

HY-128347

M‑89	Epigenetic Reader Domain	Inflammation/Immunology Cancer
M-89 is a highly potent and specific menin inhibitor, with a K_d of 1.4 nM for binding to menin. M-89 inhibits the *menin-mixed lineage leukemia* (Menin-MLL) protein-protein interaction** and has potential to treat MLL leukemia .

HY-114162B

VTP50469 mesylate	Epigenetic Reader Domain Apoptosis	Cancer
VTP50469 mesylate is a potent, and selective Menin-MLL1 inhibitor that effectively targets MLL-rearranged and NPM1c+ leukemia. VTP50469 mesylate selectively kills cell lines with MLL rearrangements and NPM1c+ mutations. VTP50469 mesylate displaces Menin from protein complexes and inhibits MLL's chromatin occupancy at specific genes, leading to significant changes in gene expression, differentiation, and apoptosis. VTP50469 demonstrates dramatic reductions in leukemia burden in patient-derived xenograft models of MLL-r acute myeloid leukemia and MLL-r acute lymphoblastic leukemia, with some mice remaining disease-free for over a year post-treatment.

HY-N0128

Sclareol 2 Publications Verification	Apoptosis	Cancer
Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia?(P-388), human epidermal?carcinoma?(KB) cells and human?leukemia?cell lines. Sclareol induces cell apoptosis .

HY-172154

SSB-2548	CXCR Apoptosis	Cancer
SSB-2548 is a CXCR-4 inhibitor. SSB-2548 can inhibit the proliferation, migration and induce apoptosis of acute myeloid leukemia cells. SSB-2548 has good gastrointestinal absorption and can be used in the research of leukemia .

HY-N8426

4'-O-Methylnyasol Ellisinin A	Histamine Receptor	Cancer
4'-O-Methylnyasol is an inhibitor of β-hexosaminidase. 4'-O-Methylnyasol inhibits β-hexosaminidase release from rat basophilic leukemia-2H3 cells with an IC₅₀ of 52.67 μM .

HY-155288

DosatiLink-1	Bcr-Abl	Cancer
DosatiLink-1 is an Abelson murine leukemia (ABL) enzyme inhibitor .

HY-155289

DosatiLink-2	Bcr-Abl	Cancer
DosatiLink-2 is an Abelson murine leukemia (ABL) enzyme inhibitor .

HY-117948

ML399	Epigenetic Reader Domain	Cancer
ML399 is a *Menin-Mixed Lineage Leukemia* (MLL)** protein-protein interaction inhibitor.

HY-155290

PonatiLink-1-24	Bcr-Abl	Cancer
PonatiLink-1-24 is an Abelson murine leukemia (ABL) enzyme inhibitor .

HY-129983

5-Hydroxymethyl-2'-deoxyuridine	HSV	Infection Cancer
5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC₅₀ values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia .

HY-149805

Anticancer agent 110	Apoptosis	Cancer
Anticancer agent 110 is an anticancer agent with in vitro anticancer activity and excellent anti-leukemia potency. Anticancer agent 110 is highly cytotoxic to K-562 lineage chronic myelogenous leukemia cells at nanomolar concentrations. Anticancer agent 110 causes DNA damage and leads to apoptosis .

HY-145690

HP1328	FLT3	Cancer
HP1328 is a potent inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1328 is a benzoimidazole scaffold-based compound. HP1328 significantly reduces the leukemia burden and prolongs the survival of mice with FLT3/ITD leukemia .

HY-111134

TAN 420C	Antibiotic	Infection Cancer
TAN 420C is an antibiotic that shows a strong cytotoxic activity against the lymphocytic leukemia .

HY-158341

IOX5	HIF/HIF Prolyl-Hydroxylase Apoptosis	Cancer
IOX5 is a selective prolyl hydroxylase (PHD) inhibitor with an IC₅₀ of 0.19 μM for PHD2. IOX5 stabilizes HIF-1α in acute myeloid leukemia (AML) cells, inhibits cell proliferation and induces apoptosis. IOX5 has anti-leukemia activity .

HY-N15387

Hericenone J	Drug Derivative	Cancer
Hericenone J (Compound 6) is an aromatic compound with anticancer activity, which is found in Hericium erinaceum. Hericenone J is cytotoxic and can significantly reduce the viability of HL-60 human acute promyelocytic leukemia cells with an IC₅₀ value of 4.13 μM. Hericenone J is promising for research of leukemia .

HY-123950

MMRi64	MDM-2/p53 Apoptosis	Cancer
MMRi64 disrupts Mdm2-MdmX interactions. MMRi64 downregulates Mdm2 and MdmX in leukemia cells. MMRi64 induces p53 accumulation, and induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells. MMRi64 can be used for cancer research .

HY-169843

Cotylenin A	c-Myc	Cancer
Cotylenin A is a type of phenanthraquinone compound that works alongside vitamin K2 to induce the differentiation of monocytes and halt their growth, while also inhibiting the expression of c-Myc and inducing the expression of cyclin G2 in human leukemia HL-60 cells. Cotylenin A can be used in studies on acute myeloid leukemia .

HY-N13878

Anguinomycin B	Antibiotic Bacterial	Infection
Anguinomycin B is an antitumor antibiotic that shows highly cytotoxic to murine P388 leukemia cells .

HY-N10591

Bruceantarin	Others	Cancer
Bruceantarin is a potent antineoplastic agent. Bruceantarin can be used for leukemia and breast cancer research .

HY-155557

Anti-inflammatory agent 45	Apoptosis	Cancer
Anti-inflammatory agent 45 (compound 2v) is an anticancer agent with direct inhibitory effects on the growth of different blood cancers including leukemia, lymphoma and myeloma cell lines. Anti-inflammatory agent 45 induces apoptosis and inhibits NO production in HL60 leukemia cells (IC₅₀=14.7 μM) .

HY-114699

DC_YM21	Endogenous Metabolite	Cancer
DC_YM21 is an inhibitor of menin-MLL interaction with potent and selective proliferation blocking activity. DC_YM21 can induce cell cycle arrest and differentiation of leukemia cells carrying MLL translocation. DC_YM21 shows potential application value in inhibiting MLL leukemia .

HY-124069

M-525	Epigenetic Reader Domain	Cancer
M-525 is a first-in-class, highly potent, irreversible and covalent menin-MLL protein-protein interaction inhibitor. M-525 binds to menin with an IC₅₀ of 3 nM and achieves low nanomolar potencies in cell growth inhibition and in suppression of MLL regulated gene expression in MLL leukemia cells. Anti-leukemia activity .

HY-125151

BP-1-108	STAT Apoptosis	Cancer
BP-1-108 is a selective inhibitor of STAT5 (K_i=8.3 μM) with anticancer activity. BP-1-108 induces apoptosis of leukemia cells by inhibiting the phosphorylation of STAT5. BP-1-108 can be used in the study of acute myeloid leukemia and prostate cancer .

HY-19171

Aranose	Drug Derivative	Cancer
Aranose is a nitrosourea derivative with antineoplastic activity. Aranose can be used for leukemia, plasmacytoma, and solid tumor research .

HY-N2517

Dihydroevocarpine	mTOR	Cancer
Dihydroevocarpine induces cytotoxicity in acute myeloid leukemia via suppressing the mTORC1/2 activity .

HY-N0128R

Sclareol (Standard)	Apoptosis	Cancer
Sclareol (Standard) is the analytical standard of Sclareol. This product is intended for research and analytical applications. Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

HY-N8386

Berkeleylactone F	Antibiotic	Infection Cancer
Berkeleylactone F is an antibiotic macrolide compound. Berkeleylactone F showed modest inhibition of CCRF-CEM leukemia cells .

HY-124350

10-Formylfolic acid	Antifolate Dihydrofolate reductase (DHFR)	Cancer
10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia .

HY-139877

OXS007417	Microtubule/Tubulin	Cancer
OXS007417 induces differentiation of acute myeloid leukemia cells (EC₅₀ = 48 nM) in vitro and shows antitumor effects in vivo.

HY-113200

N1-Acetylspermine	Endogenous Metabolite	Cancer
N1-Acetylspermine is an endogenous metabolite present in Urine that can be used for the research of Leukemia .

HY-W016836

Metanilic acid	Endogenous Metabolite	Cancer
Metanilic acid, recognized for its anti-cancer properties, is utilized in the treatment of various malignancies, such as choriocarcinoma and pediatric acute lymphoblastic leukemia.

HY-168681

Sirtuin-IN-2	Sirtuin	Cancer
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, which is a key target for leukemia and breast cancer .

HY-126156

Leucodin Desacetoxymatricarin	Bacterial	Cancer
Leucodin is a sesquiterpene lactone derived from Gynoxys verrucosa. Leucodin has cytotoxic activity on human leukemia cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0128

Sclareol 2 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Diterpenoids Artemisia mexicana Willd. Plants Erigeron breviscapus (Vant.) Hand.-Mazz. Disease Research Fields Cancer	Apoptosis
Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia?(P-388), human epidermal?carcinoma?(KB) cells and human?leukemia?cell lines. Sclareol induces cell apoptosis .

HY-N2517

Dihydroevocarpine	Alkaloids Classification of Application Fields Source classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Quinoline Alkaloids Plants Disease Research Fields Cancer	mTOR
Dihydroevocarpine induces cytotoxicity in acute myeloid leukemia via suppressing the mTORC1/2 activity .

HY-N10206

11-epi-Chaetomugilin I	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

HY-N8426

4'-O-Methylnyasol Ellisinin A	Structural Classification Natural Products Liliaceae Source classification Anemarrhena asphodeloides Bunge Plants	Histamine Receptor
4'-O-Methylnyasol is an inhibitor of β-hexosaminidase. 4'-O-Methylnyasol inhibits β-hexosaminidase release from rat basophilic leukemia-2H3 cells with an IC₅₀ of 52.67 μM .

HY-111134

TAN 420C	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Fields Other Antibiotics Cancer	Antibiotic
TAN 420C is an antibiotic that shows a strong cytotoxic activity against the lymphocytic leukemia .

HY-N15387

Hericenone J	Structural Classification Monophenols Microorganisms Source classification Phenols	Drug Derivative
Hericenone J (Compound 6) is an aromatic compound with anticancer activity, which is found in Hericium erinaceum. Hericenone J is cytotoxic and can significantly reduce the viability of HL-60 human acute promyelocytic leukemia cells with an IC₅₀ value of 4.13 μM. Hericenone J is promising for research of leukemia .

HY-169843

Cotylenin A	Structural Classification Microorganisms Antibiotics Source classification	c-Myc
Cotylenin A is a type of phenanthraquinone compound that works alongside vitamin K2 to induce the differentiation of monocytes and halt their growth, while also inhibiting the expression of c-Myc and inducing the expression of cyclin G2 in human leukemia HL-60 cells. Cotylenin A can be used in studies on acute myeloid leukemia .

HY-N13878

Anguinomycin B	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Anguinomycin B is an antitumor antibiotic that shows highly cytotoxic to murine P388 leukemia cells .

HY-N10591

Bruceantarin	Structural Classification Natural Products Simaroubaceae Plants Brucea javanica (L.) Merr.	Others
Bruceantarin is a potent antineoplastic agent. Bruceantarin can be used for leukemia and breast cancer research .

HY-N0128R

Sclareol (Standard)	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Artemisia mexicana Willd. Plants Erigeron breviscapus (Vant.) Hand.-Mazz.	Apoptosis
Sclareol (Standard) is the analytical standard of Sclareol. This product is intended for research and analytical applications. Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

HY-N8386

Berkeleylactone F	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Antibiotic
Berkeleylactone F is an antibiotic macrolide compound. Berkeleylactone F showed modest inhibition of CCRF-CEM leukemia cells .

HY-126156

Leucodin Desacetoxymatricarin	Structural Classification Gynoxys verrucosa Sch.Bip. ex Wedd. Terpenoids Sesquiterpenes Source classification Plants Compositae	Bacterial
Leucodin is a sesquiterpene lactone derived from Gynoxys verrucosa. Leucodin has cytotoxic activity on human leukemia cells .

HY-113200A

N1-Acetylspermine trihydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
N1-Acetylspermine trihydrochloride is an endogenous metabolite present in Urine that can be used for the research of Leukemia .

HY-N1830

3-Epiwilsonine	Alkaloids Structural Classification Cephalotaxus sinensis var. wilsoniana (Hayata) L. K. Fu & Nan Li Other Alkaloids Taxaceae Source classification Plants	Others
3-Epiwilsonine is an alkaloid from Cephalotaxus wilsoniana, exhibits effect on acute and chronic myeloid leukemia and malignant lymphoma .

HY-N0117

Indirubin 5+ Cited Publications Couroupitine B; Indigo red; Indigopurpurin	Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Cancer	Apoptosis
Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .

HY-122997

Acetylaleuritolic acid	Triterpenes Structural Classification Jatropha macrorhiza Benth. Terpenoids Source classification Euphorbiaceae Plants	Others
Acetylaleuritolic acid is a triterpenoid isolated from Jatropha curcas that exhibits tumor suppressive properties against the P-388 lymphocytic leukemia test system.

HY-N7651

Neoanhydropodophyllol	Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Others
Neoanhydropodophyllol is a cyclolignan derivative, with antineoplastic activity. Neoanhydropodophyllol displays cytotoxicity against several cancer cells (leukemia, lung carcinoma and colon carcinoma) .

HY-N5007

Galgravin	Structural Classification Classification of Application Fields Magnoliaceae Source classification Lignans Magnolia Liliflora Desr. Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis
Galgravin is an active compound in Nectandra megapotamica, with anti-inflammatory activity. Galgravin displays in vitro cytotoxic activity and induce apoptosis in leukemia cells .

HY-N14697

Cytorhodin X	Quinones Structural Classification Microorganisms Source classification Naphthalene Quinones	Antibiotic
Cytorhodin X is a cytotoxic antibiotic. Cytorhodin X can inhibit the proliferation of L1210 murine leukemia cells, with an ED₅₀ of 0.36 μM .

HY-N6037

Gardenin B 1 Publications Verification	Structural Classification Monophenols Flavonoids Classification of Application Fields Flavones Source classification Rubiaceae Phenols Plants Gardenia jasminoides Ellis Disease Research Fields Cancer	Apoptosis
Gardenin B is a flavonoid isolated from Gardenia jasminoides. Gardenin B induces cell death in human leukemia cells involves multiple caspases .

HY-126030

(+)-Syringaresinol	Structural Classification Classification of Application Fields Source classification Lignans Phenols Polyphenols Antheroporum pierrei Gagnep. Phenylpropanoids Plants Compositae Disease Research Fields Cancer	Nuclear Factor of activated T Cells (NFAT)
(+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC₅₀ of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia .

HY-125321

Lychnostatin 2	Structural Classification Natural Products Lychnophora antillana Source classification Plants Compositae	Others
Lychnostatin 2 exhibits cytotoxicity in cell P-388 with an ED₅₀ of 0.19 µg/ml. Lychnostatin 2 can be used in research abour leukemia .

HY-N1112

Uncargenin C	Triterpenes Structural Classification Staphyleaceae Terpenoids Source classification Plants Turpinia arguta (Lindl.) Seem.	Others
Uncargenin C is a triterpenoid, which can be isolated from Uncaria rhychophyllo Miq. Jacks. The intermediate of Uncargenin C has anti-leukemia activity, but not itself .

HY-N0564

Notopterol 1 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Source classification Coumarins Phenylpropanoids Kleinia odora (Forssk.) DC. Umbelliferae Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML) .

HY-102010

Pancratistatin (+)-Pancratistatin	Structural Classification Natural Products Source classification Hymenocallis littoralis (Jacq.) Salisb. Plants Amaryllidaceae	Apoptosis
Pancratistatin is an isoquinoline alkaloid that can be isolated from Hymenocallis littoralis. Pancratistatin induces apoptosis of human melanoma cells. Pancratistatin can be used for the research of neuroblastoma, leukemia and breast cancer .

HY-N10071

Poricoic acid G	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Poricoic acid G is a triterpenoid that can be isolated from Poria cocos. Poricoic acid G has a significant cytotoxic effect on leukemia cells and is a potential potent anti-leukemic compound in humans .

HY-N3308

Medicarpin 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Leguminosae Source classification Phenols Plants Disease Research Fields Medicago sativa L. Cancer	Apoptosis
Medicarpin is a flavonoid isolated from Medicago sativa. Medicarpin induces apoptosis and overcome multidrug resistance in leukemia P388 cells by modulating P-gp-mediated efflux of agents .

HY-B0722

Histamine dihydrochloride 5+ Cited Publications	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Reactive Oxygen Species
Histamine dihydrochloride is a reactive oxygen species (ROS) inhibitor. Histamine dihydrochloride can suppress ROS production and work together with IL-2 to activate T cells and NK cells, leading to immune activation in the tumor microenvironment, which consequently kills acute myeloid leukemia (AML) cells. Histamine dihydrochloride can cause a reduction in vaginal tetrazo reduction, increased epithelial growth, and heightened keratinization in mouse models of ovariectomy. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

HY-N13910

Alnumycin	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Alnumycin is a naphthoquinone antibiotic with a narrow-spectrum antimicrobial activity against Gram-positive bacteria. Alnumycin inhibits the growth of K562 human leukemia cells with an IC₅₀ of 0.53 μg/mL .

HY-N2732

6-Prenylapigenin 6-Prenyl-4',5,7-trihydroxyflavone; 6-C-Prenylapigenin	Structural Classification Flavonoids Flavones Source classification Maclura pomifera (Raf.) Schneid. Plants Moraceae	Others
6-Prenylapigenin is a biologically active flavonoid with anti-tumor activity and antiangiogenic properties. 6-Prenylapigenin exerts cytotoxicity against cancer cells, such as leukemia and solid cancer cells .

HY-119784

Eupenifeldin	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	Fungal
Eupenifeldin is pentacyclic bistropolone isolated from cultures of Eupenicillium brefeldianum ATCC 74184. Eupenifeldin is cytotoxic against the HCT-116 cell line. Eupenifeldin has the potential for the research of leukemia .

HY-N13894

Auramycin A	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Antibiotic Bacterial
Auramycin A, an anthracycline antibiotic that shows marked antibacterial activity against Gram-positive bacteria. Auramycin A also exhibits antitumor activity against P388 and L1210 leukemia in mice .

HY-N6017

Bakkenolide A	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Cancer Corethrodendron multijugum (Maximowicz) B. H. Choi & H. Ohashi	HDAC
Bakkenolide A is a natural product extracted from Petasites tricholobus. Bakkenolide A inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways .

HY-N8390

3-Epidehydropachymic acid	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Poria cocos Plants Disease Research Fields Cancer	Others
3-Epidehydropachymic acid, a lanostane triterpenoid, shows totoxicity effect against human acute monocytic leukemia cell line THP-1 (IC₅₀=52.51 μM) .

HY-N13294

Cernuumolide J TMJ-105	Structural Classification Terpenoids Carpesium cernuum L. Sesquiterpenes Source classification Plants Compositae	Apoptosis JAK STAT p38 MAPK JNK ERK
Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of JNK and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC₅₀ value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy .

HY-N13895

Auramycin B	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Antibiotic Bacterial
Auramycin B, an anthracycline antibiotic that shows marked antibacterial activity against Gram-positive bacteria. Auramycin B also exhibits antitumor activity against P388 and L1210 leukemia in mice .

HY-126556

Cytochalasin J	Structural Classification Natural Products Microorganisms Source classification	Microtubule/Tubulin
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC₅₀ of 1.5 μM .

HY-N0117R

Indirubin (Standard)	Alkaloids Structural Classification other families Source classification Plants Indole Alkaloids	Apoptosis
Indirubin (Standard) is the analytical standard of Indirubin. This product is intended for research and analytical applications. Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .

HY-N9159

Piptocarphin F	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Dalbergia frutescens (Vell.) Britton	Others
Piptocarphin F (Compound 5) is a sesquiterpene lactone. Piptocarphin F shows cytotoxic activity on human leukemia cell line HL-60 (IC₅₀=5.69 μmol*L ^-1) .

HY-N2387

Pinosylvin	Infection Structural Classification Stilbenes Classification of Application Fields Polygonaceae Reynoutria japonica Houtt. Source classification Phenols Polyphenols Plants Disease Research Fields	Bacterial Apoptosis Autophagy
Pinosylvin is a?pre-infectious stilbenoid toxin?isolated from the heartwood of Pinus species, has anti-bacterial activities . Pinosylvin is a resveratrol analogue, can induce cell apoptosis and autophapy in leukemia cells .

HY-N9210

1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid	Ketones, Aldehydes, Acids Source classification Euphorbiaceae Plants	Others
1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid, a ellagic acid derivative of Agrostistachys hookeri, exhibits activity against cultured P-388 lymphocytic leukemia cells .

HY-124210

Formycin B	Structural Classification Microorganisms Antibiotics Source classification	Antibiotic Parasite
Formycin B is an antibiotic, which exhibits antiparasitic activity against Leishmania. Formycin B exhibits toxicity to leukocytes, reversibly decreases neutrophils. Formycin B can be used in research about myeloid leukemia .

HY-118726

Luotonin F	Structural Classification Alkaloids Peganum nigellastrum Bunge Zygophyllaceae Source classification Quinoline Alkaloids Plants	Topoisomerase
Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II .

HY-111588

Xanthoangelol 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Plants Infection Chalcones Flavonoids Phenols Polyphenols Umbelliferae Ondetia linearis Benth. Inflammation/Immunology Disease Research Fields	Apoptosis Monoamine Oxidase Bacterial AMPK Caspase
Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells .

HY-N2108

7-Ethylcamptothecin	Alkaloids Structural Classification other families Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Cancer	ADC Cytotoxin
7-Ethylcamptothecin is one of camptothecin analogues. camptothecin (CPT), a cytotoxic alkaloid isolated from Camptotheca acuminata, is shown to have strong antitumor activity against L1210 leukemia and Walker 256 carcinosarcoma models .

HY-N0488A

Vincristine Leurocristine; NSC-67574; 22-Oxovincaleukoblastine	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Cancer	Antibiotic Microtubule/Tubulin
Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine is used to research hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas .

HY-N1056

Yunnancoronarin A Zerumbetol	Structural Classification Hedychium forrestii Diels Terpenoids Source classification Diterpenoids Plants Zingiberaceae	Others
Yunnancoronarin A (Zerumbetol) can be isolated from Hedychium forrestii. Yunnancoronarin A is cytotoxic, with IC₅₀ values of 11.08 and 2.19 μM against lung adenocarcinoma cells A549 and leukemia cells K562, respectively .

HY-N0840

Bruceantin 1 Publications Verification (-)-Bruceantin; NCI165563; NSC165563	Simaroubaceae Classification of Application Fields Brucea antidysenterica J.F.Mill. Terpenoids Source classification Diterpenoids Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.	Others
Bruceantin(NSC165563) is first isolated from Brucea javanica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.

HY-Y0949R

Methyl 2-furoate (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
10-Formylfolic acid (Standard) is the analytical standard of 10-Formylfolic acid. This product is intended for research and analytical applications. 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia .

HY-B0722R

Histamine (dihydrochloride) (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite Reactive Oxygen Species
Histamine (dihydrochloride) (Standard) is the analytical standard of Histamine (dihydrochloride). This product is intended for research and analytical applications. Histamine dihydrochloride is a reactive oxygen species (ROS) inhibitor. Histamine dihydrochloride can suppress ROS production and work together with IL-2 to activate T cells and NK cells, leading to immune activation in the tumor microenvironment, which consequently kills acute myeloid leukemia (AML) cells. Histamine dihydrochloride can cause a reduction in vaginal tetrazo reduction, increased epithelial growth, and heightened keratinization in mouse models of ovariectomy. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

Cat. No.	Product Name	Chemical Structure

HY-14519S

Methotrexate-d3

Methotrexate-d₃ (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

HY-153939S

Idasanutlin-d3-1
Idasanutlin-d₃-1 (RG7388-d₃-1) is the deuterium labeled Idasanutlin. Idasanutlin is a potent antagonist of MDM2/p53. Idasanutlin inhibits relapsed or refractory acute myeloid leukemia .

HY-14519S1

Methotrexate-d3 diammonium

Methotrexate-d₃ diammonium is the deuterium labeled Methotrexate diammonium. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) .

HY-W654130

Daunorubicin-13C,d3

Daunorubicin- ¹³C,d₃ is ¹³C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13593S

Chlorambucil-d8
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-13593S1

Chlorambucil-d8-1
Chlorambucil-d₈-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-N8593S

Undecane-d24
Undecane-d₂₄ is the deuterium labeled Undecane[1]. Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[2].

HY-148036S

FLT3-IN-16-d1
FLT3-IN-16-d1 is the deuterium labeled FLT3-IN-16 (HY-148036). FLT3-IN-16 is a potent FLT3 inhibitor with an IC₅₀ of 1.1 μM. FLT3-IN-16 can be used for researching acute myeloid leukemia .

HY-W757743

Acalabrutinib-d3
Acalabrutinib-d₃ (ACP-196-d₃) is the deuterated form of Acalabrutinib (HY-17600). Acalabrutinib (ACP-196) is an orally active, irreversible, highly selective second-generation BTK inhibitor. Acalabrutinib covalently binds to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib shows strong targeting and efficacy in mouse models of chronic lymphocytic leukemia (CLL).

HY-13653S1

(-)-Epigallocatechin Gallate-d4

(-)-Epigallocatechin Gallate-d4 (EGCG-d4) is the deuterium labeled (-)-Epigallocatechin Gallate (HY-13653). (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

HY-125771S

1-Stearoyl-sn-glycero-3-phosphocholine-d35

1-Stearoyl-sn-glycero-3-phosphocholine-d₃₅ is deuterium labeled 1-Stearoyl-sn-glycero-3-phosphocholine (HY-125771). 1-Stearoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine that inhibits HDAC3 activity and phosphorylation of STAT3 in K562 cells. 1-Stearoyl-sn-glycero-3-phosphocholine induces apoptosis and exhibits anticancer activity in chronic myelogenous leukemia (CML) K562 cells .

HY-50907S

ABT-737-d8

ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research .

HY-B0660S1

Eicosapentaenoic acid 1,2,3,4,5-13C5

Eicosapentaenoic acid 1,2,3,4,5- ¹³C₅ (EPA 1,2,3,4,5- ¹³C, FA 20:5- ¹³C₅) is ¹³C labeled Eicosapentaenoic Acid. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

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