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antiwrinkle efficacy

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985

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6

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1

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8

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64

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14

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73

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24

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Oligonucleotides

Cat. No. Product Name Target Research Area
  • HY-P0033
    Argireline

    Acetyl hexapeptide-3

    		 Peptides Neurological Disease
    Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline significantly inhibits Ca 2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity .
  • HY-P5232
    Tetrapeptide-21

    		Peptides Others
    Tetrapeptide-21 is a bioactive peptide with anti-wrinkle and and reducing skin hyperpigmentation effect, and has been reported used as a cosmetic ingredient .
  • HY-P0033A
    Argireline acetate

    Acetyl hexapeptide-3 acetate

    		 Peptides Neurological Disease
    Argireline acetate (Acetyl hexapeptide-3 acetate) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline acetate significantly inhibits Ca 2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline acetate has antiwrinkle and anti-aging activity .
  • HY-P5220
    Acetyl hexapeptide-1

    Melitane

    		 Peptides Others
    Acetyl hexapeptide-1 (Melitane) is a bioactive peptide with anti-wrinkle effect and can be used as a cosmetic ingredient .
  • HY-P5220A
    Acetyl hexapeptide-1 acetate

    Melitane acetate

    		 Peptides Others
    Acetyl hexapeptide-1 acetate (Melitane acetate) is a bioactive peptide with anti-wrinkle effect and can be used as a cosmetic ingredient .
  • HY-P0065
    Acetyl octapeptide-1

    		Peptides Others
    Acetyl octapeptide-1 is a bioactive peptide with anti-wrinkle effect and has been reported used as a cosmetic ingredient .
  • HY-P2709
    Rigin

    Tetrapeptide-3; GQPR

    		 Peptides Others
    Rigin (Tetrapeptide-3; GQPR) is a bioactive peptide with anti-wrinkle effect and has been reported used as a cosmetic ingredient .
  • HY-P5240
    Acetyl tripeptide-30 citrulline

    		Peptides Others
    Acetyl tripeptide-30 citrulline is a bioactive peptide with anti-wrinkle effect and has been reported used as a cosmetic ingredient .
  • HY-P5230
    Manganese tripeptide-1

    		Peptides Others
    Manganese tripeptide-1 is a bioactive peptide with anti-wrinkle and reducing skin hyperpigmentation effect, and has been reported used as a cosmetic ingredient .
  • HY-P5206
    Garvicin KS, GakB

    		Bacterial Infection
    Garvicin KS, GakB is a peptide at sizes of 34 amino acids to form bacteriocin garvicin KS (GarKS), with other 2 peptides, GakA, and GakC. Garvicin KS, GakB inhibits fibroblast viability and proliferation. Garvicin KS, GakB with GakA, is a potent combination with good peptide stability, antimicrobial efficacy, and fibroblast viability/proliferation effects. Garvicin KS peptides inhibit MSSA with MIC values in the order GakB >GakC >GakA .
  • HY-P5262
    Tripeptide-10

    		Peptides Metabolic Disease
    Tripeptide-10 is a bioactive peptide withanti-wrinkleeffect and has been reported used as a cosmetic ingredient .
  • HY-P0104
    Palmitoyl tripeptide-38

    		Reactive Oxygen Species Metabolic Disease
    Palmitoyl tripeptide-38 is a bioactive peptide with anti-aging effect .
  • HY-125745
    Loloatin B 10

    		Antibiotic Bacterial Infection
    Loloatin B 10 is an antibiotic, which exhibits antibacterial efficacy against gram positive antibiotic resistant human pathogens .
  • HY-P1615
    Cenupatide

    		Peptides Cancer
    Cenupatide (UPARANT) is a Urokinase-type plasminogen activator receptor (uPAR) inhibitor. Cenupatide has anti-angiogenic and anti-inflammatory efficacy .
  • HY-P2374
    Ac-DMQD-CHO

    		Caspase Apoptosis Neurological Disease
    Ac-DMQD-CHO is a selective inhibitor for caspase 3, with IC50 of 39 nM. Ac-DMQD-CHO reduces apoptosis, and exhibits neuroprotective efficacy .
  • HY-P10233
    SAAP 148

    		Bacterial Infection
    SAAP 148 is an antimicrobial and antibiofilm agent, and exhibits inhibitory efficacy against antibiotic-resistant pathogens, with LC50 of 0.8-12.8 μM .
  • HY-P2341
    Angiopep-2 hydrochloride
    1 Publications Verification

    		 LDLR Cancer
    Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer .
  • HY-P10233A
    SAAP 148 TFA

    		Bacterial Infection
    SAAP 148 TFA is an antimicrobial and antibiofilm agent, and exhibits inhibitory efficacy against antibiotic-resistant pathogens, with LC50 of 0.8-12.8 μM .
  • HY-P10255
    K90-114TAT

    		Potassium Channel Cancer
    K90-114TAT is an inhibitor for EAG2-Kvβ2 interaction, and exhibits antitumor efficacy against glioblastomas .
  • HY-P0090A
    Calcitonin (salmon) (acetate)

    Salmon calcitonin acetate

    		 CGRP Receptor Cancer
    Calcitonin (salmon) (acetate) is a dual-action amylin and calcitonin receptor agonist, can stimulate bone formation and inhibit bone resorption .The acetate form can affect the absorption and efficacy of hormones .
  • HY-P1919
    [Asp371]-Tyrosinase (369-377), human

    		Peptides Cancer
    Tyrosinase 369-377, human is a HLA-A2.1-restricted epitope derived from tyrosinase, has been used to develop tumor-targeted vaccines with mixed efficacy .
  • HY-162396
    P-gp inhibitor 21

    		P-glycoprotein Cancer
    P-gp inhibitor 21 (Compound 56) is an inhibitor for P-glycoprotein (P-gp) transport, which reverses P-gp-mediated multidrug resistance (MDR) and exhibits antitumor efficacy in mice without significant cytotoxicity .
  • HY-19648
    Ebiratide

    HOE-427 free base

    		 nAChR Neurological Disease
    Ebiratide (HOE-427 free base) is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide enhances acetycholine (ACh) metabolism in rat brain .
  • HY-P10773
    CTP-amiodarone

    		Peptide-Drug Conjugates (PDCs) Calcium Channel Potassium Channel Sodium Channel Adrenergic Receptor Cardiovascular Disease
    CTP-amiodarone is a cell-penetrating conjugate of cardiomyocyte targeting peptide and Amiodarone (HY-14187). CTP-amiodarone exhibits antiarrhythmic efficacy through block of Na+, K+, Ca2+ channels and β-adrenergic receptors .
  • HY-19648B
    Ebiratide TFA

    HOE-427 TFA

    		 nAChR Neurological Disease
    Ebiratide (HOE-427) TFA is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide TFA enhances acetycholine (ACh) metabolism in rat brain .
  • HY-P10431
    Hc-CATH

    Sea snake cathelicidin

    		 Bacterial Infection Inflammation/Immunology
    Hc-CATH (Sea snake cathelicidin) is an antibacterial peptide with broad-spectrum. Hc-CATH inhibits Shigella dysenteriae and Klebsiella pneumoniae with MIC of 0.16 mM-20.67 mM. Hc-CATH exhibits anti-inflammatory efficacy .
  • HY-P2382
    TRV120056

    		Peptides Others
    TRV120056 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein .
  • HY-P10200
    CP7-FP13-2

    		Bacterial Infection
    CP7-FP13-2 is a peptide with antivirulence factor and antibacterial activity. CP7-FP13-2 inhibits the formation of Staphylococcus aureus biofilm and has good antibacterial efficacy in mice .
  • HY-P10498
    [Des-Tyr1]-gamma-Endorphin

    		Peptides Neurological Disease
    [Des-Tyr1]-gamma-Endorphin is a neuropeptide, which can be found in human cerebrospinal fluid. [Des-Tyr1]-gamma-Endorphin exhibits antidepressant efficacy, facilitates the extinction of active avoidance and attenuates the passive avoidance behavior in rats .
  • HY-P1351
    Angiopep-2-Cys

    		Peptides Cancer
    Angiopep-2-cys is a conjugate of Angiopep-2 hydrochloride (HY-P2341) and cysteine. Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer .
  • HY-P1253
    α-Endorphin (human)

    		Opioid Receptor Neurological Disease
    α-Endorphin (human) is a neuropeptide, that acts on the central nervous system (CNS) and peripheral nervous system (PNS). α-Endorphin (human) binds μ-opioid receptor, and exhibits analgesic efficacy. α-Endorphin (human) regulates sexual behaviors and pleasure felling .
  • HY-P10235
    Cyclic AC253

    		Amylin Receptor Neurological Disease
    Cyclic AC253 is an antagonist for amylin receptor, with IC50 of 0.3 μM. Cyclic AC253 exhibits neuroprotective efficacy against Aβ toxicity and abrogates Aβ-induced impairment of hippocampal long-term potentiation. Cyclic AC253 penetrate blood-brain barrier (BBB) .
  • HY-P4072
    (D)-PPA 1

    		PD-1/PD-L1 Cancer
    (D)-PPA 1 is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy .
  • HY-P10239
    Tyr3-Octreotate

    		Radionuclide-Drug Conjugates (RDCs) Cancer
    Tyr3-Octreotate is a somatostatin analog. Tyr3-Octreotate exhibits high uptake into tumor, that is capable to be labeled with radioactive metal and thus exhibits antitumor efficacy . Tyr3-Octreotate can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
  • HY-122357
    Bestim

    		Adenylate Cyclase Inflammation/Immunology
    Bestim is a dipeptide, which exhibits high affinity to murine peritoneal macrophages, thymocytes, and plasma membranes isolated from these cells, with Kds of 3.1, 2.1, 18.6 and 16.7 nM, respectively. Bestim inhibits adenylate cyclase in the membranes of murine macrophages and thymocytes. Bestim exhibits immunomodulatory efficacy .
  • HY-P2381
    Sar-Arg-Val-Tyr-Val-His-NH2
    1 Publications Verification

    		 Peptides Others
    Sar-Arg-Val-Tyr-Val-His-NH2 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein .
  • HY-P1711
    L 366763

    		Peptides Cardiovascular Disease
    L 366763 is a potent peptide that acts as a fibrinogen receptor antagonist, preventing collagen-induced platelet aggregation and adhesion. L 366763 inhibits platelet deposition and maintains blood flow in a baboon thrombosis model, significantly prolonging bleeding time. L 366763 has antithrombotic efficacy, whereas recombinant LAPP does not have the same effect .
  • HY-P4072A
    (D)-PPA 1 TFA

    		PD-1/PD-L1 Cancer
    (D)-PPA 1 TFA is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 TFA serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 TFA binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy .
  • HY-P2428
    RI-61

    		Peptides Neurological Disease
    RI-61 is a compound that has activity in suppressing migraine, cluster headache, new daily persistent headache and cyclical vomiting syndrome. RI-61 has shown significant efficacy in relieving the symptoms of these disorders. RI-61 helps relieve pain and other related symptoms by modulating the action of neurotransmitters .
  • HY-P10708
    SVS-1 peptide

    		Peptides Cancer
    SVS-1 peptide is an anticancer peptide. SVS-1 peptide can selectively recognize cancer cells through electrostatic interactions, disrupt the cell membrane structure, and lead to cell death. Unlike antimicrobial peptides, the efficacy of SVS-1 peptide occurs before complete neutralization of the membrane charge .
  • HY-P3350
    LS-BF1

    		Bacterial Infection
    LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].
  • HY-149205
    CXJ-2

    		PI3K ERK Inflammation/Immunology
    CXJ-2 is a cyclic peptide, and exhibits moderate affinity toward elastin derived peptides (EDPs). CXJ-2 exhibits potent activities to inhibit the PI3K/ERK pathway and decrease hepatic stellate cell proliferation and migration. CXJ-2 possesses potent antifibrotic efficacy .
  • HY-P10759
    DTS-201 sodium

    		Peptide-Drug Conjugates (PDCs) Aminopeptidase Cancer
    DTS-201 sodium (CPI-0004Na) is a peptidic prodrug of Doxorubicin (HY-15142A). DTS-201, comprising the tetrapeptide portion, is cleaved by endopeptidases in the tumor environment to produce metabolites that subsequently enter the cell and are converted to active Doxorubicin. DTS-201 shows antitumoral efficacy in tumor xenograft models of prostate, breast, and lung cancer .
  • HY-P10839
    NBD peptide

    		NF-κB Inflammation/Immunology
    NBD peptide inhibits NF-κB signaling pathway through inhibition of the NEMO-IKK complex combination. NBD peptide exhibits anti-inflammatory efficacy through block of pro-inflammatory cytokines production. NBD peptide exhibits immunosuppressive activity through regulation of immune cells. NBD peptide enhances its transmembrane ability by combining with cell-penetrating peptide HIV-TAT .
  • HY-N6693
    Valinomycin
    4 Publications Verification

    NSC 122023

    		 Apoptosis Antibiotic Autophagy Fungal Infection Others Cancer
    Valinomycin is a potassium-specific ionophore, the valinomycin-K + complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K + gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .
  • HY-P10439
    CVRARTR

    		PD-1/PD-L1 Cancer
    CVRARTR is an antagonist for programmed cell death ligand-1 (PD-L1) with KD of 281 nM. CVRARTR induces the internalization of PD-L1 and downregulates PD-L1 on the cell surface. CVRARTR restores cytokine secretion and T cell proliferation in cell CT26. CVRARTR exhibits antitumor efficacy against in CT26 homograft mouse model .
  • HY-P1640
    (Trp63,Trp64)​-​C3a(63-77)

    		Complement System Inflammation/Immunology
    (Trp63,Trp64)​-​C3a(63-77) is a C3a synthetic analogue peptide, which exhibits Ca 2+ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC50 of 9.5, 2.0 and 0.8 nM, respectively .
  • HY-144292
    HDAC-IN-30

    		HDAC Cancer
    HDAC-IN-30 is a novel multi-target HDAC inhibitor, including HDAC1 (IC50=13.4 nM),HDAC2 (IC50=28.0 nM), HDAC3 (IC50=9.18 nM), HDAC6 (IC50=42.7 nM), HDAC8 (IC50=131 nM). HDAC-IN-30 exhibits potent antitumor efficacy .
  • HY-P5205
    Garvicin KS, GakA

    		Bacterial Infection
    Garvicin KS, GakA is a peptide at sizes of 34 amino acids to form bacteriocin garvicin KS (GarKS), with other 2 peptides, GakB, and GakC. Garvicin KS, GakA inhibits fibroblast viability and proliferation. Garvicin KS, GakA with GakB, is a potent combination with good peptide stability, antimicrobial efficacy, and fibroblast viability/proliferation effects. Garvicin KS peptides inhibit MSSA with MIC values in the order GakB >GakC >GakA .
  • HY-P10696
    C16G2

    		Bacterial Antibiotic Infection
    C16G2 is a specific targeted antimicrobial peptide (STAMP) that targets the cariogenic oral pathogen Streptococcus mutans. C16G2 specifically recognizes and disrupts the bacterial cell membrane, causing small molecule leakage and loss of membrane potential, leading to bacterial killing. Unlike broad-spectrum antimicrobial peptides, C16G2 exhibits higher selectivity and efficacy against Streptococcus mutans .

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