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Results for "

ros

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ROS Kinase (54) Acyltransferase (1) Adenosine Receptor (3) Akt (21) Aldehyde Dehydrogenase (ALDH) (5) Aldose Reductase (1) AMPK (7) Amyloid-β (5) Anaplastic lymphoma kinase (ALK) (24) Androgen Receptor (2) Angiotensin Receptor (3) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (18) AP-1 (2) Apoptosis (274) Arenavirus (1) ATF6 (1) Atg8/LC3 (3) ATP Synthase (2) Autophagy (78) Bacterial (48) Bcl-2 Family (16) Bcr-Abl (2) BCRP (1) Biochemical Assay Reagents (9) Btk (1) c-Met/HGFR (9) c-Myc (3) Calcium Channel (8) Cannabinoid Receptor (2) Carbonic Anhydrase (2) Carboxylesterase (1) Caspase (18) CaSR (1) CDK (6) Chemerin Receptor (2) Cholinesterase (ChE) (14) Complement System (1) COMT (1) COX (17) Cuproptosis (4) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (7) Deubiquitinase (1) Dihydroorotate Dehydrogenase (1) Discoidin Domain Receptor (2) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (9) Drug Metabolite (4) Dynamin (1) DYRK (2) EBV (1) EGFR (10) Endogenous Metabolite (77) Enterovirus (1) ERK (13) Estrogen Receptor/ERR (4) FAK (2) Fatty Acid Synthase (FASN) (1) Ferroportin (1) Ferroptosis (38) FKBP (1) FLT3 (2) Fluorescent Dye (17) Fungal (33) GABA Receptor (2) Glucosidase (1) Glutaminase (3) Glutathione Peroxidase (6) Glutathione S-transferase (1) GnRH Receptor (1) GSK-3 (3) HBV (7) HCV (3) HDAC (9) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (5) Histamine Receptor (4) Histone Methyltransferase (1) HIV (6) HMG-CoA Reductase (HMGCR) (5) HSP (3) HSV (3) IGF-1R (1) iGluR (1) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (9) Interleukin Related (10) Isotope-Labeled Compounds (19) JAK (6) JNK (11) Keap1-Nrf2 (20) Lactate Dehydrogenase (3) Lipoxygenase (6) MAP3K (3) MDM-2/p53 (11) mGluR (1) Microtubule/Tubulin (15) Mitochondrial Metabolism (20) Mixed Lineage Kinase (1) MMP (8) Monoamine Oxidase (9) mTOR (5) Na+/Ca2+ Exchanger (2) NADPH Oxidase (8) NAMPT (2) Necroptosis (3) NEDD8-activating Enzyme (1) NF-κB (24) NKCC (1) NO Synthase (7) NOD-like Receptor (NLR) (10) Notch (2) Nuclear Factor of activated T Cells (NFAT) (1) Nucleoside Antimetabolite/Analog (1) Oct3/4 (1) Organoid (1) Oxidative Phosphorylation (5) P-glycoprotein (3) P2Y Receptor (1) p38 MAPK (8) p62 (3) Paraptosis (2) Parasite (20) PARP (4) PD-1/PD-L1 (3) PDGFR (1) PDHK (1) PDK-1 (1) Phosphatase (5) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (15) PIN1 (1) PKA (2) PKC (3) Polo-like Kinase (PLK) (1) Potassium Channel (7) PPAR (8) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (2) PROTACs (2) Proteasome (3) Pyroptosis (6) Pyruvate Kinase (1) Raf (1) RAR/RXR (1) Ras (3) Reactive Oxygen Species (439) RIP kinase (1) ROR (2) SARS-CoV (5) SGLT (1) Sigma Receptor (5) Sirtuin (4) Small Interfering RNA (siRNA) (3) SOD (2) STAT (6) STING (1) Survivin (1) TAM Receptor (1) Tau Protein (2) TGF-beta/Smad (6) TGF-β Receptor (1) TNF Receptor (8) Toll-like Receptor (TLR) (4) Topoisomerase (16) Trk Receptor (6) TRP Channel (3) TrxR (7) Tyrosinase (3) VDAC (1) VEGFR (6) Virus Protease (2) Xanthine Oxidase (4) β-catenin (4) γ-secretase (1)
By Research Areas:	Cancer (424) Cardiovascular Disease (58) Endocrinology (10) Infection (112) Inflammation/Immunology (185) Metabolic Disease (85) Neurological Disease (117)
Click Chemistry:	Azide (1) Alkynes (1)
Oligonucleotides:	Nucleotides and their Analogs (1) Pre-designed siRNA Sets (3) siRNAs (3)

763

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

226

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

ROS-generating agent 1	Reactive Oxygen Species TrxR Ferroptosis Apoptosis	Cancer
ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities .

ROS-ERS inducer 1	Reactive Oxygen Species	Cancer
ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin .

ROS-IN-1	Reactive Oxygen Species	Infection Neurological Disease Inflammation/Immunology Cancer
ROS-IN-1 is a mitochondrial *ROS* inhibitor. ROS-IN-1 can reduce oxidative stress or inhibit reactive oxygen species (ROS) production .

ROS1-IN-2	ROS Kinase	Cancer
ROS1-IN-2 (Compound 3) is a *ROS1* inhibitor. ROS1-IN-2 can be used in the study of cancer .

ROS inducer 1	Bacterial Reactive Oxygen Species	Infection
ROS inducer 1 (compound I₂₉) is a fungicide, with EC₅₀ against Xanthomonas axonopodis pv. citri (Xac), Xanthomonas oryzae pv. oryzae (Xoo), and Pseudomonas syringae pv. actinidiae (Psa) of 5.73, 6.62 and 9.05 μg/mL. ROS inducer 1 can effectively induce the production of ROS in Xanthomonas cells and inhibit rice bacterial blight. ROS inducer 1 has the potential to study bacterial infection in crops .

ROS inducer 4	Reactive Oxygen Species Mitochondrial Metabolism Apoptosis	Cancer
ROS inducer 4 (compound TE3) is a mitochondrial inhibitor. ROS inducer 4 causes a series of mitochondria-related physiological changes in tumors, such as mitochondrial fragmentation, explosive generation and accumulation of *ROS, decreased mitochondrial membrane potential, decreased ATP content, and activation of ROS-mediated apoptotic* signaling in mitochondria .

ROS inducer 2	Reactive Oxygen Species	Infection
ROS inducer 2 (Compound I16) is a ROS inducer. ROS inducer 2 has good activity in vitro, with an EC₅₀ of 3.43 μg/mL. ROS inducer 2 has outstanding bioactivities in vivo against Xanthomonas axonopodis pv. citri. ROS inducer 2, as a bactericidal agent, can be used for the research of intractable plant bacterial diseases .

ROS inducer 3	Reactive Oxygen Species	Infection
ROS inducer 3 (Compound I6) is a ROS inducer. ROS inducer 3 has excellent in vitro bioactivity with an EC₅₀ of 2.86 μg/mL. ROS inducer 3 has significant protective activity for preventing Pseudomonas syringae pv. actinidiae. ROS inducer 2, as a bactericidal agent, can be used for the research of intractable plant bacterial diseases .

ROS 234	Histamine Receptor	Inflammation/Immunology
ROS 234 is a potent H3 antagonist, with a pK_B of 9.46 for Guinea-pig ileum H₃-receptor, a pK_i of 8.90 for Rat cerebral cortex H₃-receptor, and a ED₅₀ of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diaplays poor central access .

ROS-IN-2	Reactive Oxygen Species	Others
ROS-IN-2 (compound 85) is a seco-lupane triterpenoid derivative. ROS-IN-2 blocks *ROS* production and protects mitochondria from damage by inhibiting excessive production of oxidative stressors. ROS-IN-2 can be used for myocardial ischemia/reperfusion (MI/R) injury research .

ROS1-IN-1	ROS Kinase	Cancer
ROS1-IN-1 (Compound 31) is a potent and selective *ROS1* kinase inhibitor with an IC₅₀ of 0.097 μM .

ROS 234 dioxalate	Histamine Receptor	Inflammation/Immunology
ROS 234 dioxalate is a potent H3 antagonist, with a pK_B of 9.46 for Guinea-pig ileum H₃-receptor, a pK_i of 8.90 for Rat cerebral cortex H₃-receptor, and a ED₅₀ of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 dioxalate diaplays poor central access .

ROS kinases-IN-1	ROS Kinase	Cancer
ROS kinases-IN-1 (pag 98) is a ROS tyrosine kinase inhibitor with IC₅₀ value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity .

ROS kinases-IN-2	ROS Kinase	Cancer
ROS kinases-IN-2 is a ROS kinase inhibitor with 21.53% inhibition at 10 μM .

ROS tracer precursor	Biochemical Assay Reagents	Neurological Disease
ROS tracer precursor is the precursor of [ ¹⁸F]ROStrace for the synthesis of ROStrace, which can be used for disease diagnosis .

ROS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ROS1 Human Pre-designed siRNA Set A contains three designed siRNAs for ROS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ros1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ros1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ros1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

ROS1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ROS1 Rat Pre-designed siRNA Set A contains three designed siRNAs for ROS1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dihydrotetramethylrosamine DHTM ros	Fluorescent Dye	Others
Dihydrotetramethylrosamine (DHTM Ros) is a fluorogenic substrate for peroxidase that oxidizes to fluorescent tetramethylrosamine chloride.

*ALK/ROS1-IN-4*	Anaplastic lymphoma kinase (ALK) ROS Kinase	Cancer
ALK/ROS1-IN-4 (example 13) is a dual inhibitor of ALK and ROS1 kinase .

*ALK/ROS1-IN-4 hydrate*	Anaplastic lymphoma kinase (ALK) ROS Kinase	Cancer
ALK/ROS1-IN-4 (hydrate) (example 13) is a dual inhibitor of ALK and ROS1 kinase .

*ALK/ROS1-IN-3*	ROS Kinase Anaplastic lymphoma kinase (ALK)	Cancer
ALK/ROS1-IN-3 (compound C01) is a *ROS1* and ALK dual inhibitor with IC₅₀s of 42.3 nM and 49.1 nM for ROS1 ^G2032R and ALK ^G1202R, respectively .

*ALK/ROS1-IN-1*	Anaplastic lymphoma kinase (ALK) ROS Kinase	Cancer
ALK/ROS1-IN-1 (compound 2e) is a potent and selective anti crizotinib-resistant *ALK/ROS1* dual inhibitor, with IC₅₀s of 0.174 μM and 0.530 μM for ALK and ROS1 enzyme, respectively.

QD394	Reactive Oxygen Species	Cancer
QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis .

Piperkadsin A	Reactive Oxygen Species	Inflammation/Immunology Cancer
Piperkadsin A is a potent inhibitor of *ROS. Piperkadsin inhibits PMA-induced ROS* production in human polymorphonuclear neutrophils with an IC₅₀ of 4.3 μM .

Xanthine oxidase-IN-12	Xanthine Oxidase Reactive Oxygen Species	Inflammation/Immunology
Xanthine oxidase-IN-12 (Compound 11) is a xanthine oxidase (XO) inhibitor with an IC₅₀ of 91 nM. Xanthine oxidase-IN-12 also has antioxidant activity and reduces intracellular ROS .

Anticancer agent 120	Bacterial Reactive Oxygen Species Apoptosis	Cancer
Anticancer agent 120 (compound 21) is an N-acylated ciprofloxacin derivative, which has certain antibacterial activity and induces *ROS* to promote cancer cell apoptosis .

PPARα agonist 3	PPAR Reactive Oxygen Species	Inflammation/Immunology
PPARα agonist 3 (Compound A229) is a PPARα agonist (EC₅₀: 590 nM). PPARα agonist 3 inhibits TBHP or 4-HNE (HY-113466)-induced production of ROS .

3,5-Di-tert-butylphenol	Fungal Reactive Oxygen Species	Infection
3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities. 3,5-Di-tert-butylphenol induces accumulation of reactive oxygen species (ROS).

Dimethachlor	Apoptosis Reactive Oxygen Species	Metabolic Disease
Dimethachlor, a synthetic herbicide, inhibits the undesirable growth of weeds via the suppression of very long-chain fatty acid synthesis. Dimethachlor disrupts normal developmental processes via the induction of apoptosis and ROS production .

Bisphenol AF-13C12 BPAF-¹³C₁₂; 4,4'-(Perfluoropropane-2,2-diyl)diphenol-¹³C₁₂	Isotope-Labeled Compounds	Others
Bisphenol AF- ¹³C₁₂ is an isotopic label of Bisphenol AF. Bisphenol AF is used in polycarbonate plastic and epoxy resin manufacturing. Bisphenol AF can significantly increase intracellular ROS levels .

MitoB bromide	Reactive Oxygen Species	Inflammation/Immunology
MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. MitoB bromide is a mitochondria-targeted ratiometric probe, and can be used to measure levels of one major ROS, hydrogen peroxide, within living animals .

PRO-F	Fluorescent Dye	Inflammation/Immunology
PRO-F is a photoactivable H₂S donor with ROS scavenging ability. PRO-F can be activated by light to produce fluorescent signal, for real-time tracking of released H₂S. PRO-F activation doesn’t consume endogenous substances. deliver H₂S in an intracellular environment to protect cells from excessive reactive oxygen species (ROS) induced damage. PRO-F shows enhancement on chronic wound healing, researched in diabetic models as well .

p38-α MAPK-IN-7	p38 MAPK	Neurological Disease
p38-α MAPK-IN-7 (compound 4) is a p38α-MAPK inhibitor with an IC₅₀ value of 98.7 nM. p38-α MAPK-IN-7 protects neuronal cells from dexamethasone-induced *ROS* production .

5-Galloylquinic acid 1 Publications Verification	Reactive Oxygen Species	Cancer
5-Galloylquinic acid, an main scavenger of the reactive oxygen species (ROS) in green tea .

CT-2584	Reactive Oxygen Species	Cancer
CT-2584 is a chemotherapeutic compound that reduces the expression of NKEF-B in several tumor cell types and kills tumor cells by inducing the production of *ROS* in mitochondria, commonly used in cancer research .

DPP23	Others	Cancer
DPP23 exerts antitumor activity through ROS-mediated apoptosis in cancer cells, but does not play a role in healthy cells. DPP23 can up-regulate the expression of ATF4 .

SKF1	FKBP Reactive Oxygen Species	Infection
SKF1 is a FK506 suppressor, causes a mitochondrially induced death in low salt, concomitant with the release of reactive oxygen species (ROS) .

(Rac)-Phox-I1	Others	Others
(Rac)-Phox-I1 is a racemic isomer of Phox-I1. Phox-I1 is a p67 ^phox inhibitor. Phox-I1 inhibits *ROS* production .

Xanthine oxidase, Microorganism 1 Publications Verification XO; XOD	Reactive Oxygen Species	Inflammation/Immunology Endocrinology
Xanthine oxidase, Microorganism (XO) is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid .

Moracin C 1 Publications Verification	Reactive Oxygen Species COX	Inflammation/Immunology
Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells .

Xanthine oxidase, bovine milk	Reactive Oxygen Species	Inflammation/Immunology Endocrinology
Xanthine oxidase, bovine milk is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid .

Apoptosis inducer 13	Apoptosis Reactive Oxygen Species	Cancer
Apoptosis inducer 13 (Compound Ru4) can induce cancer cell apoptosis, and inhibits cancer cell migration and invasion. Apoptosis inducer 13 converts coenzyme NADH to NAD ⁺, and increases intracellular *ROS* levels .

Sonlicromanol KH176	Reactive Oxygen Species	Metabolic Disease
Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease .

Spiraeoside Quercetin 4′-O-glucoside	Reactive Oxygen Species	Inflammation/Immunology Cancer
Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities .

Pennogenin	Reactive Oxygen Species	Inflammation/Immunology
Pennogenin is a bioactive component which can be isolated from T. govanianum rhizomes. Pennogenin exhibits significant in vitro inhibitory effect on release of ROS .

Cat. No.	Product Name

HY-L075

Anti-Lung Cancer Compound Library

1,970 compounds

Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers.

As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy.

MCE offers a unique collection of 1,970 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.

HY-L089

Mitochondria-Targeted Compound Library

960 compounds

Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

MCE supplies a unique collection of 960 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

HY-L045

Oxygen Sensing Compound Library

2,723 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 2,723 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

HY-L051

Ferroptosis Compound Library

993 compounds

Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

MCE carefully collected a unique collection of 993 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

HY-L178

Radioprotector Library

1,938 compounds

Radiation sickness is a general term for various types and degrees of damage (or disease) occurring in the human body after exposure to ionizing radiation. Although small amounts of ionizing radiation can also cause the body to produce free radicals and ROS, causing oxidative stress, resulting in DNA damage and chromosomal aberration. Radioprotector are compounds with radiation protection that can be used to prevent/protect non-tumor cells from the harmful effects of radiation. Radioprotective compounds can prevent the damage of radioactive substances to the human body and reduce the clinical symptoms of various radioactive diseases. In addition, radioprotectors can protect normal cells from damage during radiation therapy. The ideal anti-radiation drug should not affect the sensitivity of tumor cells to radiation therapy while protecting normal cells.

MCE designs a unique collection of 1,938 radioprotectors. Radioprotector Library is an effective tool for acute Radiation Syndrome, drug combination research with radiation drugs.

Cat. No.	Product Name	Type

HY-W040143

2',7'-Dichlorofluorescein	Fluorescent Dyes/Probes
2',7'-Dichlorofluorescein acts as a fluorescent probe (Ex=496 nm and Em=525 nm) for reactive oxygen species (ROS) measurement .

HY-D1055

MitoSOX Red

45+ Cited Publications

Fluorescent Dyes/Probes

MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red.
Excitation/emission wavelength: 510/580 nm.

HY-111330

Hydroxyphenyl Fluorescein

1 Publications Verification

HPF; 3'-p-(Hydroxyphenyl) fluorescein

Fluorescent Dyes/Probes

Hydroxyphenyl Fluorescein (HPF) is a stable ROS fluorescent probe dye. Hydroxyphenyl Fluorescein has stronger specificity and stability than H2DCFDA (HY-D0940). Hydroxyphenyl Fluorescein can produce strong green fluorescence through hydroxyl radical reaction with intracellular peroxynitroso. Hydroxyphenyl Fluorescein can be applied for fluorescence microscopy, high-throughput imager, luciferase microplate reader or flow cytometry. Ex/Em=490/515 nm .

HY-D1653

BDP 581/591 NHS ester

Fluorescent Dyes/Probes

BDP 581/591 NHS ester is a a borondipyrromethene dye (Ex=585 nm, Em=594 nm) that has relatively long fluorescence lifetime and two photon excitation cross section. BDP 581/591 NHS ester can be used for fluorescence polarization analysis and also reacts with reactive oxygen species (ROS) and alter fluorescence. BDP 581/591 NHS ester is also an NHS ester derivative that can be used to bind primary and secondary amine groups of proteins, peptides and other molecules.

HY-B0166GL

L-Ascorbic acid (GMP Like)

L-Ascorbate (GMP Like); Vitamin C (GMP Like)

Fluorescent Dye

L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid (HY-B0166). L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-123533

Resorufin NSC 12097	Fluorescent Dyes/Probes
Resorufin (NSC 12097) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte .

HY-123533A

Resorufin sodium salt NSC 12097 sodium salt	Fluorescent Dyes/Probes
Resorufin sodium salt (NSC 12097 sodium salt) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte .

HY-D1740

Dihydrotetramethylrosamine DHTM ros	Fluorescent Dyes/Probes
Dihydrotetramethylrosamine (DHTM Ros) is a fluorogenic substrate for peroxidase that oxidizes to fluorescent tetramethylrosamine chloride.

HY-D1656

BDP 581/591 carboxylic acid	Fluorescent Dyes/Probes
BDP 581/591 carboxylic acid is a fluorescent dye (Ex=585 nm, Em=594 nm). BDP 581/591 carboxylic acid has a free carboxylic acid group, which can be catalyzed by a catalyst (such as EDC or HATU) to react with primary amines to form stable amide bonds. BDP 581/591 carboxylic acid is highly photostable and can be used for ROS detection.

HY-D1655

BDP 581/591 DBCO	Fluorescent Dyes/Probes
BDP 581/591 DBCO is a borondipyrromethene dye with a conjugated olefin system (Ex=585 nm, Em=594 nm). BDP 581/591 DBCO can be used as a conventional fluorophore or for the detection of ROS (after oxidation, fluorescence moves to the green part of the spectrum).

HY-D0940

H2DCFDA Maximum Cited Publications 317 Publications Verification DCFH-DA; 2',7'-Dichlorodihydrofluorescein diacetate	Fluorescent Dyes/Probes
H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm) .

HY-W011664

1,3-Diphenylisobenzofuran

4 Publications Verification

DPBF

Fluorescent Dyes/Probes

1,3-Diphenylisobenzofuran (DPBF) has been developed as a selective probe for the detection and quantitative determination of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS). DPBF is a fluorescent probe which, for almost 20 years, was believed to react in a highly specific manner toward some reactive oxygen species such as singlet oxygen and hydroxy, alkyloxy or alkylperoxy radicals .

HY-D2227

IR-58	Fluorescent Dyes/Probes
IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS)-Akt-mTOR pathway .

HY-D1713

CM-H2DCFDA 3 Publications Verification	Fluorescent Dyes/Probes
CM-H2DCFDA is a derivative of H2DCFDA (HY-D0940). CM-H2DCFDA can be used to determine cellular oxidant levels (Ex/Em: 495/530 nm). CM-H2DCFDA is light-sensitive .

HY-103469

Peroxy Orange 1 1 Publications Verification PO1	Fluorescent Dyes/Probes
Peroxy Orange 1 (PO1) is a new H₂O₂ specific probe that can bind to green fluorescent highly reactive oxygen species (hROS) probe APF. Peroxy Orange 1 is also a living cell dye .

HY-126793

2′,7′-Dichlorofluorescein diacetate 5+ Cited Publications DCFH2-DA	Fluorescent Dyes/Probes
2′,7′-Dichlorofluorescein diacetate (DCFH2-DA) is a cell-permeable fluorescent probe. 2′,7′-Dichlorofluorescein diacetate can be used to detect the generation of reactive oxygen intermediates and for assessing the overall oxidative stress in toxicological phenomenon .

HY-15930

TMB

1 Publications Verification

BM blue; Sure Blue TMB

Chromogenic Substrates

TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-15930A

TMB dihydrochloride

1 Publications Verification

BM blue dihydrochloride; Sure Blue TMB dihydrochloride

Chromogenic Substrates

TMB dihydrochloride is the dihydrochloride form of TMB (HY-15930). TMB dihydrochloride is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB dihydrochloride can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB dihydrochloride can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-15930C

TMB monosulfate

1 Publications Verification

BM blue monosulfate; Sure Blue TMB monosulfate

Chromogenic Substrates

TMB monosulfate is the monosulfate form of TMB (HY-15930). TMB monosulfate is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB monosulfate can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB monosulfate can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-D1157

HKPerox-2 3 Publications Verification	Fluorescent Dyes/Probes
HKPerox-2 is a highly sensitive green fluorescent probe for the specific detection of H₂O₂ in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively .

Cat. No.	Product Name	Type

HY-W015913

Sodium 2-oxopropanoate Maximum Cited Publications 8 Publications Verification Sodium pyruvate	Cell Assay Reagents
Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge *ROS* .

HY-W015913R

Sodium 2-oxopropanoate (standard) 3 Publications Verification	Biochemical Assay Reagents
Sodium 2-oxopropanoate (Standard) is the analytical standard of Sodium 2-oxopropanoate. This product is intended for research and analytical applications. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge *ROS* .

HY-B0166GL

L-Ascorbic acid (GMP Like)

L-Ascorbate (GMP Like); Vitamin C (GMP Like)

Biochemical Assay Reagents

HY-125857

Cytochrome C	Cell Assay Reagents
Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis .

HY-W127530

α-Tocopherol phosphate disodium

3 Publications Verification

alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium

Biochemical Assay Reagents

α-Tocopherol phosphate (alpha-Tocopherol phosphate) disodium, a promising antioxidant, can protect against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium possesses therapeutic potential in the inhibition of apoptosis and increases the migratory capacity of endothelial progenitor cells under high-glucose/hypoxic conditions and promotes angiogenesis .

HY-131553

D-α-Tocopherol Succinate 1 Publications Verification Vitamin E succinate	Biochemical Assay Reagents
D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer .

HY-126712

ROS tracer precursor	Biochemical Assay Reagents
ROS tracer precursor is the precursor of [ ¹⁸F]ROStrace for the synthesis of ROStrace, which can be used for disease diagnosis .

HY-W250307

Diphenyliodonium iodide	Biochemical Assay Reagents
Diphenyliodonium iodide is an inhibitor of reactive oxygen species (ROS). Diphenyliodonium iodide can inhibit the accumulation of bisdemethoxycurcumin in fresh-cut yam by inhibiting the phenylpropanoid pathway and the biosynthesis of bisdemethoxycurcumin, thereby preventing the yellowing of fresh-cut yam. Diphenyliodonium iodide can be used in medicine and fruit preservation .

HY-15930B

TMB dihydrochloride x.hydrate

Sure Blue TMB dihydrochloride x.hydrate

Enzyme Substrates

TMB (dihydrochloride x.hydrate) is the dihydrochloride x hydrate form of TMB (HY-15930). TMB (dihydrochloride x.hydrate) is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB (dihydrochloride x.hydrate) can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB (dihydrochloride x.hydrate) can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

Cat. No.	Product Name	Target	Research Area

HY-120234

Z-LLNle-CHO Z-Leu-Leu-Nle-CHO; GSII	γ-secretase Proteasome Apoptosis	Cancer
Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia .

HY-P3993A

(Gly14)-Humanin (human) (acetate) 14-Glycine-Humanin (human) (acetate)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions .

HY-134545

N-Arachidonoyl-L-alanine NALA	Peptides	Cancer
N-Arachidonoyl-L-alanine is an endocannabinoid analog with anti-cancer effects. N- Arachidonoyl-L-alanine kills HNSCC cells through 5-LO-mediated ROS productio .

HY-P10622

SHLP-3	Apoptosis Reactive Oxygen Species	Metabolic Disease Cancer
SHLP-3 is a mitochondrial derived peptide encoded by the 16S ribosomal RNA (MT-RNR2) gene. SHLP-3 increases cell viability and reduces apoptosis in insulinoma NIT-1β cells and human prostate cancer 22Rv1 cells. SHLP-3 increases mitochondrial function and exerts cytoprotective effects by increasing mitochondrial oxygen consumption rate (OCR), cellular ATP and reducing the ability to produce ROS. SHLP-3 can be used in the study of diabetes and cancer .

HY-P1844

Chemerin-9 (149-157)	Chemerin Receptor Akt ERK Reactive Oxygen Species Amyloid-β	Inflammation/Immunology
Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ_1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism .

HY-P5553

cPcAMP1/26	Bacterial	Infection
cPcAMP1/26 is an antimicrobial peptide. cPcAMP1/26 effectively kills A.hydrophila and S. aureus. cPcAMP1/26 induces depolarization of the bacterial plasma membrane, and increases intracellular ROS levels .

HY-P2005

Malformin C	Peptides	Others
Malformin C is an algicidal peptide can be isolated from Aspergillus and exhibits dose-dependent algicidal activity. Malformin C induces a significant increase in ROS levels in algal cells, resulting in impaired SOD activity and high production of MDA content .

HY-P1184

HNGF6A	Reactive Oxygen Species	Cardiovascular Disease Neurological Disease Metabolic Disease
HNGF6A is a humanin analogue. HNGF6A increases glucose-stimulated insulin secretion and glucose metabolism, and has the potential for diabetes research. HNGF6A inhibits of *ROS* production during oxidative stress. HNGF6A can prevent endothelial dysfunction and atherosclerosis in vivo .

HY-P1184A

HNGF6A TFA	Reactive Oxygen Species	Cardiovascular Disease Neurological Disease Metabolic Disease
HNGF6A TFA is a humanin analogue. HNGF6A TFA increases glucose-stimulated insulin secretion and glucose metabolism, and has the potential for diabetes research. HNGF6A TFA inhibits of *ROS* production during oxidative stress. HNGF6A TFA can prevent endothelial dysfunction and atherosclerosis in vivo .

HY-P10350

PapRIV	NF-κB	Neurological Disease Inflammation/Immunology
PapRIV is an agonist of BV-2 microglial cells, capable of activating microglial cells through an NF-κB-dependent pathway. PapRIV induces the expression of pro-inflammatory cytokines such as IL-6 and TNFα and increases the production of reactive oxygen species (ROS). PapRIV can cross the blood-brain barrier .

HY-D0844

Glutathione oxidized 4 Publications Verification L-Glutathione oxidized; GSSG; Oxiglutatione	Endogenous Metabolite Reactive Oxygen Species	Metabolic Disease
Glutathione oxidized (L-Glutathione oxidized) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes .

HY-P3906

Melittin free acid	Fungal Apoptosis Phospholipase Reactive Oxygen Species	Infection
Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways .

HY-P3993

(Gly14)-Humanin (human) 14-Glycine-Humanin (human)	Apoptosis	Neurological Disease
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions .

HY-P4052

Pinealon	ROS Kinase	Neurological Disease
Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia .

HY-113064

Selenocystine 1 Publications Verification	Endogenous Metabolite	Cancer
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-P5762A

Phoenixin-14 TFA PNX-14 TFA	GnRH Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Phoenixin-14 (PNX-14) TFA, a BBB-penatrable neuropeptide, has anxiolytic, cardioprotective and neuroprotective effect. Phoenixin-14 TFA can regulate pituitary gonadotrophin secretion by upregulating the GnRH receptor mRNA. Phoenixin-14 TFA stimulates insulin secretion. Phoenixin-14 TFA also protects mice from ischemia/reperfusion (IR) injury. PNX-14 TFA prevents oxidative stress by reducing ROS and increasing GSH .

HY-P1845

PACAP-38 (31-38), human, mouse, rat	ERK EGFR Reactive Oxygen Species Calcium Channel	Neurological Disease
PACAP-38 (31-38), human, mouse, rat is a PAC₁ receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research .

HY-P1844A

Chemerin-9 (149-157) (TFA) 3 Publications Verification	Chemerin Receptor Akt ERK Reactive Oxygen Species Amyloid-β	Inflammation/Immunology
Chemerin-9 (149-157) TFA is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) TFA has anti-inflammatory activity. Chemerin-9 (149-157) TFA stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) TFA ameliorates Aβ_1-42-induced memory impairmen. Chemerin-9 (149-157) TFA regulates immune responses, adipocyte differentiation, and glucose metabolism .

HY-W013494R

L-Carnosine (Standard)	Endogenous Metabolite	Metabolic Disease Cancer
L-Carnosine (Standard) is the analytical standard of L-Carnosine. This product is intended for research and analytical applications. L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging. In Vitro: L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging . L-Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of L-Carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, and ROS and free radicals scavenging ability .

HY-P1925A

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of *ROS* and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

Cat. No.	Product Name	Target	Research Area

HY-108801

Aflibercept VEGF Trap; VEGF-TRAPR1R2; VEGF-trapR1	VEGFR	Cardiovascular Disease Metabolic Disease Cancer
Aflibercept (VEGF Trap) is a soluble decoy VEGFR constructed by fusing the Ig domains of VEGFR1 and VEGFR2 with the Fc region of human IgG1. Aflibercept inhibits VEGF signaling by reducing VEGF-regulated processes. Aflibercept can be used for thr research of age-related macular degeneration (AMD) and cardiovascular disease .

HY-108801A

Aflibercept (VEGF Trap)	VEGFR	Cardiovascular Disease Metabolic Disease
Aflibercept (VEGF Trap) is a soluble decoy VEGFR constructed by fusing the Ig domains of VEGFR1 and VEGFR2 with the Fc region of human IgG1. Aflibercept inhibits VEGF signaling by reducing VEGF-regulated processes. Aflibercept can be used for thr research of age-related macular degeneration (AMD) and cardiovascular disease .

Cat. No.	Compare	Product Name	Species	Source

HY-P702714

	ROS1 Protein, Human (sf9, His) ros1; ros proto-oncogene 1, receptor tyrosine kinase; ros; MCF3; c-ros-1	Human	Sf9 insect cells
	ROS1 Protein, Human (sf9, His) is the recombinant human-derived ROS1, expressed by Sf9 insect cells , with His labeled tag. ,

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Cat. No.	Product Name		Classification

HY-N7137

Norgestrel		Alkynes
Norgestrel is a synthetic analog of progesterone, a compound commonly found in oral contraceptive pill, and a powerful neuroprotective antioxidant, preventing light-induced *ROS* in photoreceptor cells, and cell death . Norgestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159147

SIAIS039		Azide
SIAIS039 is an orally active c-ros oncogene 1 (ROS1)-specific PROTAC with DC₅₀s of 154.46 nM, 126.47 nM, 143.69 nM for HCC78 cells, Ba/F3 expressing the CD74-ROS1 fusion and Ba/F3 expressing the SDC4-ROS1 fusion, respectively. SIAIS039 suppresses cell proliferation, induces cell cycle arrest and apoptosis, and inhibits clonogenicity against ROS1-positive cells. SIAIS039 demonstrates anti-tumour effects against ROS1-driven tumor growth vivo. SIAIS039 is composed of the ALK inhibitor Brigatinib (HY-12857), a linker EM-12 (HY-138793), and a VHL ligand E3 ubiquitin ligase 1-Butyne (Red: Brigatinib; Blue: VHL ligand; Black: linker) .

Cat. No.	Product Name		Classification

HY-F0003

NADPH tetrasodium salt 5+ Cited Publications		Nucleotides and their Analogs
NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. The demand for NADPH tetrasodium salt is particularly high in proliferating cancer cells, where it acts as a cofactor for the synthesis of nucleotides, proteins, and fatty acids. NADPH tetrasodium salt is also essential for the neutralization of the dangerously high levels of reactive oxygen species (ROS) generated by increased metabolic activity. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis .

HY-RS12135

ROS1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ROS1 Human Pre-designed siRNA Set A contains three designed siRNAs for ROS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12136

Ros1 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Ros1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ros1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12137

ROS1 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ROS1 Rat Pre-designed siRNA Set A contains three designed siRNAs for ROS1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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