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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

HEK cell

" in MedChemExpress (MCE) Product Catalog:

By Targets:	BMI1 (2) Itk (2) 11β-HSD (1) 5-HT Receptor (8) Adrenergic Receptor (1) AMPK (1) Amylases (1) Amyloid-β (1) Androgen Receptor (2) Antibiotic (3) Apelin Receptor (APJ) (5) Apoptosis (7) ASCT (4) ATP Synthase (1) Autophagy (11) AUTOTACs (1) Bacterial (5) BCRP (2) Bombesin Receptor (1) Bradykinin Receptor (1) Btk (1) Calcium Channel (3) CaMK (1) Casein Kinase (1) CaSR (2) CDK (1) CFTR (1) Cholinesterase (ChE) (1) Cytochrome P450 (2) DNA/RNA Synthesis (1) Dopamine Receptor (4) Dopamine Transporter (3) Drug Metabolite (1) EAAT (1) EGFR (1) Endogenous Metabolite (9) Epigenetic Reader Domain (1) ERK (5) Estrogen Receptor/ERR (1) FAP (1) FKBP (3) Fluorescent Dye (1) Fungal (2) FXR (1) G Protein-coupled Receptor Kinase (GRK) (1) GABA Receptor (2) GHSR (1) GLP Receptor (4) Glucosidase (1) GPR119 (1) GPR35 (1) GPR55 (1) GPR88 (1) GSK-3 (1) Guanylate Cyclase (1) HIF/HIF Prolyl-Hydroxylase (2) Histone Methyltransferase (2) HIV (7) HMG-CoA Reductase (HMGCR) (6) IAP (1) iGluR (3) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (1) Interleukin Related (2) IRAK (2) Isotope-Labeled Compounds (5) JAK (1) LPL Receptor (1) mAChR (2) MAGL (2) MDM-2/p53 (1) Melanocortin Receptor (1) Melatonin Receptor (1) mGluR (5) Microtubule/Tubulin (4) Monoamine Oxidase (1) Motilin Receptor (1) mTOR (4) nAChR (1) NADPH Oxidase (1) NOD-like Receptor (NLR) (1) OAT (2) Opioid Receptor (1) P-glycoprotein (3) P2X Receptor (1) p62 (1) Parasite (3) PARP (1) PD-1/PD-L1 (1) PERK (1) Phosphatase (1) PI4K (1) Piezo Channel (1) PKG (1) Potassium Channel (6) PPAR (2) Prostaglandin Receptor (1) PROTACs (2) Protease Activated Receptor (PAR) (1) Proteasome (1) Pyroptosis (1) Raf (1) Reactive Oxygen Species (10) ROR (3) RXFP Receptor (8) SARS-CoV (2) Serotonin Transporter (1) Sirtuin (1) Sodium Channel (3) STAT (3) Thyroid Hormone Receptor (1) TNF Receptor (1) Toll-like Receptor (TLR) (5) TRP Channel (5) URAT1 (1) VEGFR (1) Wnt (1) Xanthine Oxidase (1) β-catenin (1) γ-secretase (1)
By Research Areas:	Cancer (61) Cardiovascular Disease (30) Endocrinology (3) Infection (18) Inflammation/Immunology (36) Metabolic Disease (30) Neurological Disease (46)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Aptamers (2)

193

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

539

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor BCL6 Tim3 BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1066

Apelin-17(human, bovine)	Apelin Receptor (APJ) HIV	Infection
Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC₅₀=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-N125722

Venturicidin A Aabomycin A1	ATP Synthase Antibiotic	Infection
Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.

HY-135783

AT 1001	nAChR	Neurological Disease
AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) (K_i=2.64 nM). AT 1001 reversibly blocks inward currents induced by Epibatidine (HY-101078) in HEK cells transfected with α3β4 nAChR. AT-1001 dose-dependently inhibits nicotine self-administration behavior in rats without affecting food-reinforced responding. AT 1001 can be utilized in the research of nicotine addiction and smoking cessation therapies .

HY-P1064

Apelin-36(human)	Apelin Receptor (APJ) HIV	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(human) is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC₅₀ of 20 nM. Apelin-36(human) shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC₅₀=8.61). Apelin-36 has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-P1064A

Apelin-36(human) TFA	HIV Apelin Receptor (APJ)	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(human) TFA is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC₅₀ of 20 nM. Apelin-36(human) TFA shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC5₅₀=8.61). Apelin-36(human) TFA has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-19774

GNE-0946	ROR	Inflammation/Immunology
GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC₅₀ value of 4 nM for HEK-293 cell.

HY-134988

EDP-305	FXR Phosphatase Cytochrome P450	Inflammation/Immunology
EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC₅₀ values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells). EDP-305 shows a potent and consistent antifibrotic effect. EDP-305 can be used for primary biliary cholangitis (PBC) and non-alcoholic steatohepatitis (NASH) research .

HY-P1066A

Apelin-17(human, bovine) TFA	HIV Apelin Receptor (APJ)	Infection
Apelin-17(human, bovine) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) TFA binds to human APJ receptors expressed in HEK 293 cells (pIC₅₀=9.02). Apelin-17(human, bovine) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-148939

MPX-004	iGluR	Neurological Disease
MPX-004 is a potent GluN2A antagonist. MPX-004 inhibits GluN2A-containing NMDA receptors expressed in HEK cells with an IC₅₀ of 79 nM. MPX-004 has no inhibitory effect on GluN2B or GluN2D receptor-mediated responses. MPX-004 has the potential for neuropsychiatric and developmental disorders research .

HY-169136

U 101958	Dopamine Receptor	Neurological Disease
U 101958 is full Dopamine D4 receptor agonist, with a pEC₅₀ of 8.7 in HEK293/D₄ cells .

HY-132934

Ac32Az19 1 Publications Verification	BCRP	Cancer
Ac32Az19 is a potent, nontoxic, and highly selective BCRP inhibitor with an EC₅₀ value of 13 nM in the BCRP-overexpressed HEK293/R2 cells.

HY-120538

CPG-52364	Toll-like Receptor (TLR)	Inflammation/Immunology
CPG-52364 (compound 2) is a TLR9 antagonist. CPG-52364 inhibits the HEK293-hTLR9 cell with an IC₅₀ value of 4.6 nM .

HY-109039

Praliciguat IW-1973	Guanylate Cyclase	Cardiovascular Disease
Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC₅₀ of 197 nM .

HY-19775

GNE-6468	ROR	Inflammation/Immunology
GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC₅₀ value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC₅₀ of 30 nM for IL-17 PBMC .

HY-100360

MS049	Histone Methyltransferase	Cancer
MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC₅₀s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells .

HY-100360A

MS049 dihydrochloride	Histone Methyltransferase	Cancer
MS049 dihydrochloride is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC₅₀s of 34 nM and 43 nM, respectively. MS049 dihydrochloride reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 dihydrochloride is not toxic and does not affect the growth of HEK293 cells .

HY-160811

hVEGF-IN-3	VEGFR	Cancer
hVEGF-IN-3 (compound 9) is a potent hVEGF inhibitor. hVEGF-IN-3 inhibits HT-29, MCF-7, and HEK-293 cells proliferation with IC₅₀s of 61, 142, and 114 μM .

HY-157935

17β-HSD10-IN-3	Endogenous Metabolite	Neurological Disease
17β-HSD10-IN-3 (compound 23) is a 17β-HSD10 inhibitor with the IC₅₀ of 5.59 μM. 17β-HSD10-IN-3 shows no cell cytotoxicity toward the HEK-293 cell line up to 20 μM .

HY-114962

S-22153	Melatonin Receptor	Neurological Disease
S-22153 is a potent melatonin receptor antagonist with EC₅₀ values of 19 nM, 4.6 nM for hMT₁ and hMT₂ melatonin receptor, respectively. S-22153 has K_i values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT₁, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT₂. S-22153 is a specific ligand of MT₁ and MT₂ melatonin receptors subtypes .

HY-101560

Linrodostat 4 Publications Verification BMS-986205; ONO-7701	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC₅₀ value of 1.1 nM in *IDO1*-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers .

HY-136583

28-Epirapamycin	Drug Metabolite	Others
28-Epirapamycin is an impurity of Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells .

HY-101560A

Linrodostat mesylate BMS-986205 mesylate; ONO-7701 mesylate	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
Linrodostat (BMS-986205) mesylate is a selective irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), which effectively inhibits IDO1-HEK293 mesylate cells with an IC₅₀ value of 1.1 nM. Linrodostat mesylate demonstrates good pharmacological activity in advanced cancer .

HY-15518

LCL161 25+ Cited Publications	IAP	Cancer
LCL161 is a IAP inhibitor which inhibits XIAP in HEK293 cell and cIAP1 in MDA-MB-231 cell with IC₅₀s of 35 and 0.4 nM, respectively.

HY-123663

U-101958 maleate PNU-101958 maleate	Dopamine Receptor	Neurological Disease
U-101958 (PNU-101958) maleate is a highly selective ligand and antagonist for dopamine D4 receptor, with an IC₅₀ of 2.7 nM. U-101958 maleate behaves as an agonist in HEK-293 cells expressing the human recombinant D4.4 receptor. U-101958 maleate is an antipsychotic .

HY-157503

Photosensitizer-3	Others	Cancer
Photosensitizer-3 is a photosensitizer that exhibits powerful selective killing effects on transfected HEK cells and affibody-targeted A431 cancer cells when exposed to near-infrared light excitation .

HY-163083

JN122	MDM-2/p53 Apoptosis	Cancer
JN122, a spiroindoline-containing molecule, is a MDM2 inhibitor. JN122 Inhibits MDM2/p53 protein–protein interaction and exerts robust in vivo antitumor efficacy. JN122 has antiproliferative activity in HCT-116 cells and HEK-293 cells with IC₅₀ values of 39.6 nM and 4.28μM, respectively. JN122 can promote activation of p53 and its target genes, inhibited cell cycle progression, and induced cell apoptosis .

HY-120006A

(rel)-AR234960 1 Publications Verification	ERK	Cardiovascular Disease
(rel)-AR234960 is an active relative configuration of AR234960. AR234960, a non-peptide MAS (a G protein-coupled receptor) agonist, increases both mRNA and protein levels of CTGF via ERK1/2 signaling in HEK293-MAS cells and adult human cardiac fibroblasts .

HY-136555

GSK717 5+ Cited Publications	NOD-like Receptor (NLR)	Inflammation/Immunology
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC₅₀ of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells .

HY-139848

WS-898	P-glycoprotein	Cancer
WS-898 is a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively).

HY-18332A

Amitifadine hydrochloride DOV-21947 hydrochloride; EB-1010 hydrochloride	Serotonin Transporter Dopamine Transporter	Neurological Disease
Amitifadine hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC₅₀s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

HY-100013C

2-PCCA hydrochloride	GPR88	Neurological Disease
2-PCCA hydrochloride is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC₅₀ of 116 nM in HEK293 cells.

HY-118368

L-742001 hydrochloride	Influenza Virus	Infection Inflammation/Immunology
L-742001 hydrochloride is an influenza virus PA endonuclease inhibitor, with an EC₉₀ of 4.3 μM for vRNP activity in HEK293T cells .

HY-112683

V-9302 10+ Cited Publications	ASCT	Cancer
V-9302 is a competitive antagonist of transmembrane glutamine flux. V-9302 selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 inhibits ASCT2-mediated glutamine uptake (IC₅₀=9.6 µM) in HEK-293 cells .

HY-112683A

V-9302 hydrochloride 10+ Cited Publications	ASCT	Cancer
V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC₅₀=9.6 µM) in HEK-293 cells .

HY-131891

JHU37152	mAChR	Neurological Disease
JHU37152 is a potent and brain-penetrant DREADD agonist, with EC₅₀s of 5 nM and 0.5 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37152 exhibits selective [ ³H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue .

HY-50883

BMS 299897	γ-secretase	Neurological Disease
BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC₅₀ of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).

HY-108576

Linopirdine dihydrochloride DuP 996 dihydrochloride	TRP Channel	Neurological Disease
Linopirdine dihydrochloride is a agonist of capsaicin receptor TRPV1. Linopirdine increases the intracellular calcium concentration in HEK293 cells. Linopirdine dihydrochloride exerts an excitatory action on mammalian nociceptors .

HY-146071

Antitrypanosomal agent 5	Parasite	Infection
Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC₅₀s of 1 nM and 483.3 µM against T. brucei cell growth and HEK293 cells growth , respectively .

HY-16934

ML352	Cholinesterase (ChE)	Neurological Disease
ML352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with K_i values of 92 and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively .

HY-162304

MAGL-IN-14	MAGL	Neurological Disease
MAGL-IN-14 (compound 2) is a potent inhibitor of MAGL, with IC₅₀ of 0.00289 μM and 0.002 μM in HEK293 and PC3 cells, respectively .

HY-158422

SARS-CoV-2 Mpro-IN-16	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-16 (compound 5J) is a SARS-CoV-2 Mpro inhibitor, and inhibits HEK293 cells growth .

HY-169301

Gpr35 modulator 1	GPR35	Cancer
Gpr35 modulator 1 (compound 1-18) is a potent modulator of Gpr35, with the IC₅₀ of ≤ 100 nM in HEK293 cells stably transfected with human GPR35 .

HY-131881

JHU37160 1 Publications Verification	mAChR	Neurological Disease
JHU37160 is a potent and brain-penetrant DREADD agonist, with EC₅₀s of 18.5 nM and 0.2 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37160 exhibits selective [ ³H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue .

HY-161074

PNT6555	FAP	Cancer
PNT6555 is a fibroblast activation protein-α (FAP) inhibitor. PNT6555 has antitumor activity. PNT6555 can be used for imaging of FAP-positive tumors .

HY-102028

KY1220 3 Publications Verification	Wnt β-catenin	Cancer
KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC₅₀ of 2.1 μM in HEK293 reporter cells.

HY-161742

Fumagilin-105	AUTOTACs Estrogen Receptor/ERR Autophagy p62	Cancer
Fumagilin-105 is an autophagy targeting chimera (AUTOTAC) that induces p62 self-oligomerization with DC₅₀ values of 0.7 μM for MetAP2 in HEK293 cells .

HY-120170

BMS-466442	ASCT Adrenergic Receptor Dopamine Transporter	Neurological Disease
BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC₅₀ of 11 nM. BMS-466442 inhibits [ ³H] D-serine uptake into rat brain synaptosomes, with an IC₅₀ of 400 nM. BMS-466442 can be used for schizophrenia research .

HY-136626

Z-Ala-Ala-Asn-AMC 3 Publications Verification Cbz-Ala-Ala-Asn-AMC	Fluorescent Dye	Cancer
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC .

HY-100801

L-threo-3-Hydroxyaspartic acid	EAAT	Neurological Disease
L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with K_is of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines .

HY-150766

KPC-2-IN-1	Bacterial	Infection
KPC-2-IN-1, boronic acid derivative, is a potent KPC-2 inhibitor with K_i of 0.032 μM. KPC-2-IN-1 enhances the activity of cefotaxime in KPC-2 expressing E. coli. KPC-2-IN-1 exhibits well tolerated in human HEK-293 cells, which can be used for the study of E. coli resistance to β-lactam antibiotics .

Cat. No.	Product Name	Type

HY-100545

BAPTA-AM 55+ Cited Publications	Chelators
BAPTA-AM is a well-known membrane permeable Ca ²⁺ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC₅₀s of 1.3 μM, 1.45 μM and 1.23 μM, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P1066

Apelin-17(human, bovine)	Apelin Receptor (APJ) HIV	Infection
Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC₅₀=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-P1064

Apelin-36(human)	Apelin Receptor (APJ) HIV	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(human) is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC₅₀ of 20 nM. Apelin-36(human) shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC₅₀=8.61). Apelin-36 has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-P1064A

Apelin-36(human) TFA	HIV Apelin Receptor (APJ)	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(human) TFA is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC₅₀ of 20 nM. Apelin-36(human) TFA shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC5₅₀=8.61). Apelin-36(human) TFA has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-136626

Z-Ala-Ala-Asn-AMC 3 Publications Verification Cbz-Ala-Ala-Asn-AMC	Fluorescent Dye	Cancer
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC .

HY-P1066A

Apelin-17(human, bovine) TFA	HIV Apelin Receptor (APJ)	Infection
Apelin-17(human, bovine) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) TFA binds to human APJ receptors expressed in HEK 293 cells (pIC₅₀=9.02). Apelin-17(human, bovine) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ .

HY-P5157

BmP02	Potassium Channel	Neurological Disease
BmP02 is a selective Kv1.3 channel blocker and a highly-selective Kv4.2 modulator, which can be isolated from Chinese scorpion (Buthus martensi Karsch) venom. BmP02 also delays the inactivation of Kv4.2 in HEK293T cells, with an EC₅₀ value of ~850 nM. BmP02 inhibits the transient outward potassium currents (Ito) in ventricular muscle cells .

HY-P1432A

K-(D-1-Nal)-FwLL-NH2 TFA	GHSR	Cancer
K-(D-1-Nal)-FwLL-NH2 TFA is a high affinity and potent ghrelin receptor inverse agonist (K_i values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). K-(D-1-Nal)-FwLL-NH2 blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

HY-P1065A

Apelin-36(rat, mouse) TFA	HIV Apelin Receptor (APJ)	Infection Cardiovascular Disease Metabolic Disease
Apelin-36(rat, mouse) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) TFA binds to APJ receptors with an IC₅₀ of 5.4 nM, and potently inhibits cAMP production with an EC₅₀ of 0.52 nM. Apelin-36(rat, mouse) TFA blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ .

HY-P5372

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2	Protease Activated Receptor (PAR)	Others
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biological active peptide. (Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.)

Cat. No.	Product Name

HY-K2014

PEI Transfection Reagent 5+ Cited Publications
MCE PEI Transfection Reagent is designed based on 25 kDa PEI. It has high-efficiency, low-toxicity, strong-stability, and is suitable for many cell types, such as HEK-293、HEK-293T、CHO-K1、COS-1、COS-7、NIH/3T3、Sf9、HepG2 and HeLa et, even some hard-to-transfect cells. It can also be applied to large-scale recombinant protein expression and virus production.

Cat. No.	Product Name	Target	Research Area

HY-P99499

Cetrelimab JNJ 63723283; JNJ 3283	PD-1/PD-L1 Interleukin Related TNF Receptor	Cancer
Cetrelimab (JNJ 63723283; JNJ 3283) is a human IgG4κ mAb targeting PD-1. Cetrelimab binds PD-1 (K_d=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and PD-L2 (IC₅₀s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab stimulates peripheral T cells, increases IFN-γ, IL-2, TNF-α level and inhibits tumor growth in vivo .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N125722

Venturicidin A Aabomycin A1	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	ATP Synthase Antibiotic
Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.

HY-100801

L-threo-3-Hydroxyaspartic acid	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	EAAT
L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with K_is of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines .

HY-22024

5-Hydroxyflavone	Flavonoids Monophenols other families Classification of Application Fields Flavones Source classification Phenols Plants Disease Research Fields Cancer	Others
5-Hydroxyflavone, a flavonoid ligand, shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells .

HY-10219

Rapamycin 845+ Cited Publications Sirolimus; AY-22989	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Classification of Application Fields Antibiotics Anti-aging Source classification Disease Research Disease Research Fields Cancer	mTOR FKBP Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial
Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .

HY-B1167

Ajmaline Cardiorythmine; (+)-Ajmaline	Apocynaceae Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Rauvolfia serpentina Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids	Sodium Channel
Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC₅₀ of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia .

HY-10219R

Rapamycin (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Macrolide Antibiotics Antibiotics Source classification Disease Research Endogenous metabolite	mTOR FKBP Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial
Rapamycin (Standard) is the analytical standard of Rapamycin. This product is intended for research and analytical applications. Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .

HY-119695A

Simvastatin acid ammonium Tenivastatin ammonium	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species
Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-12033

2-Methoxyestradiol 20+ Cited Publications 2-ME2; NSC-659853	Structural Classification Monophenols Classification of Application Fields Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer	Microtubule/Tubulin Reactive Oxygen Species Apoptosis Autophagy Endogenous Metabolite
2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-B1167R

Ajmaline (Standard)	Apocynaceae Alkaloids Piperidine Alkaloids Structural Classification Rauvolfia serpentina Source classification Plants Indole Alkaloids	Sodium Channel
Ajmaline (Standard) is the analytical standard of Ajmaline. This product is intended for research and analytical applications. Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC₅₀ of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia .

HY-N12007

OAT1/3-IN-1	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	OAT
OAT1/3-IN-1 (compound 7) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-1 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-1 can be used to study mercury-induced kidney damage .

HY-N12008

OAT1/3-IN-2	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	OAT
OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage .

HY-119695AR

Simvastatin acid ammonium (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	HMG-CoA Reductase (HMGCR) Reactive Oxygen Species
Simvastatin acid (ammonium) (Standard) is the analytical standard of Simvastatin acid (ammonium). This product is intended for research and analytical applications. Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-N0930B

Galegine hydrochloride	Alkaloids Classification of Application Fields Leguminosae Source classification Metabolic Disease Plants Disease Research Fields Galega officinalis Linn.	AMPK Bacterial
Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains .

HY-122416

6,8-Diprenylnaringenin Lonchocarpol A; Senegalensin	Structural Classification Classification of Application Fields Erythrinasenegalensis DC. Source classification Metabolic Disease Plants Moraceae Flavonoids Leguminosae Humulus lupulus L. Flavonones Phenols Polyphenols Disease Research Fields Cancer	BCRP
6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and ³H-Methotrexate transport (IC₅₀=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin .

HY-P99499

Cetrelimab JNJ 63723283; JNJ 3283	Classification of Application Fields Disease Research Fields Cancer	PD-1/PD-L1 Interleukin Related TNF Receptor
Cetrelimab (JNJ 63723283; JNJ 3283) is a human IgG4κ mAb targeting PD-1. Cetrelimab binds PD-1 (K_d=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and PD-L2 (IC₅₀s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab stimulates peripheral T cells, increases IFN-γ, IL-2, TNF-α level and inhibits tumor growth in vivo .

HY-B1167A

Ajmaline hydrochloride Cardiorythmine hydrochloride; (+)-Ajmaline hydrochloride	Rauvolfia verticillata (Lour.) Baill. Apocynaceae Structural Classification Natural Products Source classification Plants	Others
Ajmaline hydrochloride is a Class Ia antiarrhythmic agent. It inhibits HERG potassium channels with IC50s of 1.0 μmol/l and 42.3 μmol/l in HEK cells and moth spider oocytes respectively. The inhibitory effect of Ajmaline hydrochloride is rapid, reversible, and positive frequency dependent. It acts primarily on the open state of the HERG channel and may also be combined with the inactivated state. The inhibitory effect of ajmaline hydrochloride is dependent on aromatic residues in the S6 domain, and the sensitivity is significantly reduced in the inactivation-deficient HERG S620T channel. It can also slightly affect the activation voltage of HERG channels. Ajmaline hydrochloride's inhibitory effect on HERG channels may contribute to both its potent antiarrhythmic effects and its potential proarrhythmic risk.

Cat. No.	Product Name	Chemical Structure

HY-10219S

Rapamycin-d3
Rapamycin-d₃ is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6][7].

HY-10219S1

Rapamycin-13C,d3

Rapamycin- ¹³C,d₃ (Sirolimus- ¹³C,d₃; AY-22989- ¹³C,d₃) is the ¹³C and deuterium labeled Rapamycin (HY-10219) . Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1 . Rapamycin is an autophagy activator, an immunosuppressant .

HY-119695AS1

Simvastatin acid-d9 ammonium

Simvastatin acid-d₉ ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-119695AS

Simvastatin acid-d6 ammonium

Simvastatin acid-d₆ (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

HY-163816

Antiproliferative agent-53-d3

Antiproliferative agent-53-d3 (Compound C1) is an inhibitor for theta-mediated end joining (TMEJ) in HEK293 cell with an IC₅₀ of 0.14 µM. Antiproliferative agent-53-d3 is the inhibitor for CYP2C19 and CYP2C9 with IC₅₀ of 0.77 and 3.1 µM. Antiproliferative agent-53-d3 inhibits the proliferation of DNA repair-compromised cells, with IC₅₀ of 8.1 µM for BRCA2 ^-/- DLD-1. Antiproliferative agent-53-d3 exhibits good pharmacokinetic characteristics in CD-1 mice .

Cat. No.	Product Name		Classification

HY-150221

DB008		Alkynes
DB008 is potent and selective PARP16 inhibitor with an IC₅₀ value of 0.27 μM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively . DB008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-160050

CD63-1 aptamer sodium		Aptamers
CD63-1 aptamer sodium is a high-affinity and specific DNA aptamer targeting the CD63 protein (Kd: 38.71 nM). CD63-1 aptamer sodium efficiently binds to CD63-positive cells, including breast cancer MDA-MB-231 cells and CD63-overexpressing HEK293T cells, with moderate binding affinity (Kd~100 nM) as assessed by flow cytometry .

HY-160051

CD63-2 aptamer sodium		Aptamers
CD63-2 aptamer sodium is a high-affinity and specific DNA aptamer targeting the CD63 protein (Kd: 78.43 nM). CD63-1 aptamer sodium efficiently binds to CD63-positive cells, including breast cancer MDA-MB-231 cells and CD63-overexpressing HEK293T cells, with moderate binding affinity (Kd~100 nM) as assessed by flow cytometry .

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