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Results for "

glycoprotein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glycoprotein VI (5) P-glycoprotein (143) Transmembrane Glycoprotein (5) 5-HT Receptor (7) ADC Cytotoxin (4) Adrenergic Receptor (8) AMPK (1) Antibiotic (13) Antibody-Drug Conjugates (ADCs) (2) APC (1) Apoptosis (21) Arenavirus (4) Autophagy (14) Bacterial (14) Bcl-2 Family (1) BCRP (7) Biochemical Assay Reagents (24) c-Met/HGFR (2) Calcium Channel (13) CaMK (6) Cannabinoid Receptor (1) Carbonic Anhydrase (3) Caspase (1) CCR (1) CD28 (2) CD3 (1) CDK (1) CETP (1) CFTR (4) Chloride Channel (4) Cholinesterase (ChE) (1) CMV (1) Cytochrome P450 (17) Dipeptidyl Peptidase (2) Dopamine Receptor (12) Drug Derivative (1) Drug Intermediate (2) Drug Metabolite (6) Endogenous Metabolite (45) FGFR (1) Filovirus (11) Flavivirus (1) Fluorescent Dye (12) Fungal (5) Galectin (1) Glutathione S-transferase (1) Glycosidase (6) HBV (2) HIV (15) HIV Protease (7) HSV (5) iGluR (3) Influenza Virus (10) Integrin (29) Interleukin Related (2) Isotope-Labeled Compounds (15) Liposome (1) LYTACs (1) Mesothelin (1) MHC (2) Microtubule/Tubulin (8) Mitochondrial Metabolism (6) Monoamine Oxidase (1) Mucin (2) NF-κB (3) Opioid Receptor (2) P-selectin (4) P2Y Receptor (5) p38 MAPK (1) Parasite (7) Phosphatase (1) PI3K (2) Potassium Channel (5) PPAR (2) Prostaglandin Receptor (3) Protease Activated Receptor (PAR) (3) Pyroptosis (2) RABV (9) Ras (1) Reactive Oxygen Species (4) RSV (2) SARS-CoV (17) Ser/Thr Protease (3) Serotonin Transporter (1) sFRP-1 (2) Sigma Receptor (1) Syk (3) Synaptic Vesicle Proteins (1) TAM Receptor (2) Taste Receptor (1) Toll-like Receptor (TLR) (2) Topoisomerase (1) Transferrin Receptor (3) VSV (2) Wnt (2) β-catenin (1)
By Research Areas:	Cancer (167) Cardiovascular Disease (64) Endocrinology (6) Infection (88) Inflammation/Immunology (54) Metabolic Disease (47) Neurological Disease (34)
Click Chemistry:	Labeling and Fluorescence Imaging (1) DBCO (2) Azide (3) Alkynes (1)
Oligonucleotides:	Aptamers (4) Cationic Lipids (1)

416

Inhibitors & Agonists

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Peptides

MCE Kits

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415

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Isotope-Labeled Compounds

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Click Chemistry

Oligonucleotides

Targets Recommended: Transmembrane Glycoprotein Glycoprotein VI P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4086

*Chimeric Rabies Virus Glycoprotein* Fragment (RVG-9R)**	RABV	Infection
Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R), a chimeric peptide consisting of 29 amino acids, is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is positively charged and able to bind negatively charged nucleic acids via charge interaction .

HY-P5623B

RVG TFA RVG29 TFA; RDP TFA; Rabies Virus glycoprotein-29 TFA	Bacterial	Infection
RVG TFA is a peptide derived from Rabies Virus Glycoprotein that binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells. RVG enhances delivery of Mycobacterium tuberculosis antigens to antigen-presenting cells .

HY-P0285

Rabies Virus Glycoprotein 1 Publications Verification	RABV	Infection
Rabies Virus Glycoprotein is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.

HY-P0285A

*Rabies Virus Glycoprotein* TFA** 1 Publications Verification	RABV	Infection
Rabies Virus Glycoprotein (TFA) is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells .

HY-P1843

Glycoprotein (276-286)	Arenavirus	Infection
Glycoprotein (276-286) is a Db-restricted peptide derived from lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP), corresponds to amino acids 276-286[1].

HY-P5623

RVG RVG29; RDP; Rabies Virus glycoprotein-29	Bacterial	Infection
RVG (RVG29) is a peptide derived from Rabies Virus Glycoprotein that binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells. RVG enhances delivery of Mycobacterium tuberculosis antigens to antigen-presenting cells .

HY-W017604

3-Aminophenylboronic acid m-Aminophenylboronic acid	Biochemical Assay Reagents	Others
3-Aminophenylboronic acid (m-Aminophenylboronic acid) functionalized copper nanoclusters can rapidly, selectively and sensitively detect glycoproteins .

HY-W097785

4-Methoxybenzamidine 4-Methoxybenzimidamide	Biochemical Assay Reagents	Metabolic Disease
4-Methoxybenzimidamide is a reagent used for the determination of reducing carbohydrates and glycoproteins.

HY-W039924

N-Azidoacetylmannosamine	Drug Metabolite	Metabolic Disease
N-Azidoacetylmannosamine is an azide-labeled sugar that can be metabolically incorporated into glycoproteins. N-Azidoacetylmannosamine can then react with alkynes or phosphines that are linked to fluorescent or biotin tags for visualization or capture of the glycoproteins. N-Azidoacetylmannosamine can be used for studying glycan structures and functions in vivo .

HY-D2278

GDP-Fucose-Cy5	Fluorescent Dye	Others
GDP-Fucose-Cy5 is a fluorescent dye that can be used for labeling free glycans, glycoproteins and glycolipids .

HY-P10245

*Fusion glycoprotein* (92-106)**	RSV	Inflammation/Immunology
Fusion glycoprotein 92-106 is a polypeptide from fusion protein of respiratory syncytial virus (RSV). Fusion glycoprotein 92-106 acts as MHC class I-restricted CTL epitope, that all 15 amino acids are required for efficient recognition by cytotoxic T lymphocyte (CTL) .

HY-158464

Fetuin glycoprotein	Biochemical Assay Reagents	Others
Fetuin glycoprotein is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-P4743

*FITC-εAhx-HHV-2 Envelope Glycoprotein* G (561-578)**	HSV	Infection
FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) is a FITC labeled HHV-2 Envelope Glycoprotein G (561-578). HHV-2 Envelope Glycoprotein G (561-578) is an immunodominant region of glycoprotein G (gG-2) reactive with all herpes simplex (HSV-2) sera .

HY-P4318

*HHV-2 Envelope Glycoprotein* G (552-574)**	HSV	Infection
HHV-2 Envelope Glycoprotein G (552-574) is an immunodominant region of glycoprotein G (gG-2) reactive with all herpes simplex (HSV-2) sera .

HY-161160

Ac4ManNDAz	Fluorescent Dye	Others
Ac4ManNDAz is a cell-permeable photocross-linking probe. Ac4ManNDAz can effectively compete with endogenous sialic acid for incorporation into cell surface glycoproteins and form cross-links with glycoprotein ligands under UV light irradiation. Ac4ManNDAz can be used to study interactions between glycoproteins .

HY-P99553

Torapsel 42-89-glycoprotein; WAY164339; pMT21:PL85	P-selectin	Others
Torapsel (42-89-glycoprotein; WAY164339) is a fusion protein with immunoglobiln. Torapsel can be used to research the prevention of ischemia reperfusion injury.

HY-158466

Human IgG Glycoprotein	Biochemical Assay Reagents	Others
Human IgG Glycoprotein is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-149649

SARS-CoV-2-IN-64	SARS-CoV	Infection
SARS-CoV-2-IN-64 (compound 9), a chenodeoxycholic acid derivative, is a potent inhibitor of *spike glycoprotein* of SARS-CoV-2** .

HY-108560

(+)-Fluprostenol	Prostaglandin Receptor	Others
(+)-Fluprostenol is a potent agonist of PTGER2. (+)-Fluprostenol decreases the expression of Oviductal glycoprotein 1 (OVGP1) .

HY-157999

SDI-118	Synaptic Vesicle Proteins	Neurological Disease
SDI-118 is an orally active modulator for synaptic vesicle glycoprotein 2A (SV2A) with an IC₅₀ of 13 nM .

HY-10307

Roxifiban	Integrin	Cardiovascular Disease
Roxifiban is a *platelet glycoprotein* (GP) IIb/IIIa receptor** inhibitor that can be used in the study of angina .

HY-P1240

*Myelin Oligodendrocyte Glycoprotein* Peptide (35-55), mouse, rat** 5 Publications Verification MOG (35-55)	Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat has encephalitogenic activity and induces T?cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat induces Th1 cytokine response as well as relatively high levels of IgG antibodies. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination .

HY-P5966

*Myelin Oligodendrocyte Glycoprotein* (40-54), Rat, Mouse** MOG (40-54)	MHC	Inflammation/Immunology
Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse (MOG (40-54)) is a CD8-related self-antigenic epitope of the myelin oligodendrocyte glycoprotein (MOG) protein and is presented in association with H-2Db .

HY-108560A

15(S)-Fluprostenol	Prostaglandin Receptor	Others
15(S)-Fluprostenol is the isomer of (+)-Fluprostenol (HY-108560). (+)-Fluprostenol is a potent agonist of PTGER2. (+)-Fluprostenol decreases the expression of Oviductal glycoprotein 1 (OVGP1) .

HY-P2818B

Alkaline phosphatase, Chicken Intestine Apase, Chicken Intestine	Endogenous Metabolite	Metabolic Disease
Alkaline phosphatase, Chicken Intestine (Apase, Chicken Intestine) is an ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values .

HY-108560R

(+)-Fluprostenol (Standard)	Prostaglandin Receptor	Others
(+)-Fluprostenol (Standard) is the analytical standard of (+)-Fluprostenol. This product is intended for research and analytical applications. (+)-Fluprostenol is a potent agonist of PTGER2. (+)-Fluprostenol decreases the expression of Oviductal glycoprotein 1 (OVGP1) .

HY-10307A

Roxifiban acetate DMP 754	Integrin	Cardiovascular Disease
Roxifiban (acetate) is the acetate form of Roxifiban (HY-10307). Roxifiban (acetate) is a *platelet glycoprotein* (GP) IIb/IIIa receptor** inhibitor that can be used in research related to angina .

HY-P2818D

Alkaline phosphatase, Human liver Apase, Human liver	Endogenous Metabolite	Metabolic Disease
Alkaline phosphatase (Apase), Human liver is a glycoprotein bound to plasma membranes that hydrolyzes several monophosphate esters optimally at an alkaline pH with the release of inorganic phosphates .

HY-P1086

Cadherin Peptide, avian	Transmembrane Glycoprotein	Others
Cadherin Peptide, avian is a calcium-dependent glycoprotein. Cadherin Peptide, avian takes part in homophilic cell-cell adhesion and dose-dependently inhibits bovine brain microvessel endothelial cells (BBMECs) adhesion .

HY-P2293

Luteinizing hormone (human)	Endogenous Metabolite	Endocrinology
Luteinizing hormone (human), a heterodimeric glycoprotein hormone produced by the pituitary gland (LH), plays key roles in human reproduction .

HY-P1240A

*Myelin Oligodendrocyte Glycoprotein* Peptide (35-55), mouse, rat TFA** 5 Publications Verification MOG (35-55) TFA	Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) TFA is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA has encephalitogenic activity and induces T cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA induces Th1 cytokine response as well as relatively high levels of IgG antibodies. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA produces a relapsing-remitting neurological disease with extensive plaque-like demyelination .

HY-P3267

Holo-Bovine Transferrin 1 Publications Verification	Transferrin Receptor	Others
Holo-Bovine Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Holo-Bovine Transferrin can bind to and mediate the transport of iron .

HY-N10627

NA2 Glycan	Endogenous Metabolite	Others
NA2 Glycan is NA2 N-linked oligosaccharide. NA2 is the asialo-substructure of A2 glycan. NA2 glycan can be isolated from mammalian serum glycoproteins, such as serum IgG .

HY-150756

EBOV-GP-IN-1	Filovirus	Infection
EBOV-GP-IN-1 (Compound 28) is a potent Ebola entry inhibitor with an IC₅₀ of 0.05 μM against Ebola virus envelope glycoprotein (EBOV-GP) .

HY-P99102

Zinlirvimab 10-1074	HIV	Infection
Zinlirvimab is a human IgG1-λ2, HIV neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop) .

HY-P9934

Abciximab C7E3	Integrin	Cardiovascular Disease
Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors .

HY-P0074

GPRP 1 Publications Verification Gly-Pro-Arg-Pro; Pefa 6003	Integrin	Cardiovascular Disease
GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .

HY-P99624

Foravirumab CR4098	RABV	Infection
Foravirumab (CR4098) is a monoclonal antibody against rabies virus glycoprotein antigenic site III .

HY-P99513

Zamerovimab CTB011	RABV	Infection
Zamerovimab (CTB011) is an anti-rabies humanized IgG1κ monoclonal antibody that binds to the non-overlapping epitopes on the rabies virus (RABV) glycoprotein. Zamerovimab targets residues at and near antigenic site III. Zamerovimab can be used in rabies studies .

HY-124871

LASV inhibitor 3.3	Arenavirus	Infection
LASV inhibitor 3.3 is a Lassa fever virus (LASV) inhibitor. LASV inhibitor 3.3 binds with LASV glycoprotein (GP) and promotes virus membrane fusion and infection. LASV inhibitor 3.3 can be used for LASV infection research .

HY-P0074A

GPRP acetate 1 Publications Verification Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate	Integrin	Cardiovascular Disease
GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .

HY-115912

GPVI antagonist 3	Glycoprotein VI	Cardiovascular Disease
GPVI antagonist 3 (Compound 2) is a potential antagonist of Glycoprotein VI (GPVI). IC₅₀ values of GPVI antagonist 3 are, respectively, 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin and 51.74 μM for thrombin. Glycoprotein VI (GPVI) is a platelet major collagen receptor and a target for potent and safe antithrombotic research. GPVI antagonist 3 is a promising antiplatelet agent .

HY-115911

GPVI antagonist 2	Glycoprotein VI	Cardiovascular Disease
GPVI antagonist 2 (Compound 1) is a potential antagonist of Glycoprotein VI (GPVI). IC₅₀ values of GPVI antagonist 2 are, respectively, 0.35 μM for collagen, 0.80 μM for CRP, 195.2 μM for convulxin and 81.38 μM for thrombin. Glycoprotein VI (GPVI) is a platelet major collagen receptor and a target for potent and safe antithrombotic research. GPVI antagonist 2 is a promising antiplatelet agent .

HY-P99104

Plutavimab COVI-AMG; STI-2020	SARS-CoV	Infection
Plutavimab a human IgG1-κ anti-SARS-CoV-2 antibody, targeting to Spike (S) glycoprotein receptor binding domain (RBD) .

HY-E70054

beta-1,3-Galactosyltransferase (WbgO) CgtB	Others	Others
beta-1,3-Galactosyltransferase (WbgO) (CgtB) acts on N-glycan substrates. beta-1,3-Galactosyltransferase (WbgO) catalyzes the formation of type 1 chains on oligosaccharide, glycopeptide, and glycoprotein substrates, including itself .

HY-E70001

Recombinant Human Luteinizing Hormone	Others	Endocrinology
Recombinant Human Luteinizing Hormone is a recombinant form of Luteinizing hormone (human) (HY-P2293). Luteinizing hormone (human), a heterodimeric glycoprotein hormone produced by the pituitary gland (LH), plays key roles in human reproduction .

HY-P5623A

RVG-Cys RVG29-Cys; RDP-Cys; Rabies Virus glycoprotein-29-Cys	RABV	Others
RVG-Cys (RVG29-Cys) is based on rabies virus glycoprotein (RVG29) peptide and connected to Cys to facilitate subsequent coupling .

HY-P5623A1

RVG-Cys acetate RVG29-Cys acetate; RDP-Cys acetate; Rabies Virus glycoprotein-29-Cys acetate	RABV	Others
RVG-Cys (RVG29-Cys;RDP-Cy) acetate is based on rabies virus glycoprotein (RVG29) peptide and connected to Cys to facilitate subsequent coupling .

HY-167686

Variabilin Homopisatin	Integrin	Cardiovascular Disease
Variabilin (Homopisatin) is a potent RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. Variabilin potently inhibits platelet aggregation induced by the platelet agonists ADP, collagen, and thrombin receptor peptide SFLLRNP. Variabilin also blocks platelet adhesion to immobilized Fg. In addition, Variabilin inhibits binding of purified human GPIIb-IIIa to immobilized Fg .

HY-P2352

Fetuin, Fetal Bovine Serum 2 Publications Verification	Biochemical Assay Reagents	Metabolic Disease
Fetuin, Fetal Bovine Serum is a liver-secreted 64 kDa plasma glycoprotein isolated from fetal bovine serum. Fetuin, Fetal Bovine Serum inhibits trypsin activity and promote cellular attachment, growth, and differentiation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P0285

Rabies Virus Glycoprotein 1 Publications Verification	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	RABV
Rabies Virus Glycoprotein is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.

HY-P2352

Fetuin, Fetal Bovine Serum 2 Publications Verification	Natural Products Animals Source classification Metabolic Disease Disease Research Fields	Biochemical Assay Reagents
Fetuin, Fetal Bovine Serum is a liver-secreted 64 kDa plasma glycoprotein isolated from fetal bovine serum. Fetuin, Fetal Bovine Serum inhibits trypsin activity and promote cellular attachment, growth, and differentiation .

HY-147063

N-Acetyl-α-D-glucosamine 1-phosphate disodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-acetyl-α-d-glucosamine 1-phosphate disodium (GlcNAc-1-P), an anomeric sugar phosphate, is a key intermediate in the biosynthesis of N-linked glycoproteins. N-acetyl-α-d-glucosamine 1-phosphate disodium is a metabolic precursor of the bacterial cell-wall components teichoic acid and mureine .

HY-W009141

1-Monopalmitin Glyceryl palmitate	Source classification Plants	P-glycoprotein
1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .

HY-101916

Heparan Sulfate 10+ Cited Publications	Structural Classification Polysaccharides Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	FGFR Wnt Endogenous Metabolite
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

HY-N1941

Isosinensetin	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Plants Inflammation/Immunology Disease Research Fields	P-glycoprotein Bacterial
Isosinensetin, a polymethoxylated flavone extracted from pericarpium citri reticulatae viride, exhibits inhibition on *P-glycoprotein* (P-gp)** in MDR1-MDCKII cells .

HY-167686

Variabilin Homopisatin	Structural Classification Natural Products Source classification Plants Dalbergia variabilis Fabaceae	Integrin
Variabilin (Homopisatin) is a potent RGD-containing antagonist of glycoprotein IIb-IIIa and platelet aggregation inhibitor from the hard tick Dermacentor variabilis. Variabilin potently inhibits platelet aggregation induced by the platelet agonists ADP, collagen, and thrombin receptor peptide SFLLRNP. Variabilin also blocks platelet adhesion to immobilized Fg. In addition, Variabilin inhibits binding of purified human GPIIb-IIIa to immobilized Fg .

HY-N10177

Peniterphenyl A	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	HSV
Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits HSV-1/2 virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2 .

HY-N15297

Isotenulin	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Helenium arizonicum S.F.Blake	P-glycoprotein
Isotenulin inhibits the efflux function of P-glycoprotein by stimulation of P-glycoprotein ATPase, thereby overcoming the multidrug resistance (MDR) of cancer cells. Isotenulin exhibits cytotoxicity in multidrug-resistant cancer cell KB-vin and sensitive cancer cell HeLaS3. Isotenulin exhibits synergistic effect with Paclitaxel (HY-B0015), Vinblastine (HY-13780) and Doxorubicin (HY-15142) .

HY-N11084

Salviaplebeiaside	Structural Classification Verbenaceae Source classification Phenols Polyphenols Plants Vitex negundo Linn.	P-glycoprotein
Salviaplebeiaside is a phenolic substance can be isolated from the aerial part of Vitex negundo var. cannabifolia. Salviaplebeiaside is an inhibitor of class I p-glycoprotein .

HY-A0279A

Pristinamycin IA 1 Publications Verification Mikamycin B; Mikamycin IA	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Cyclopeptides Source classification Other Diseases Antibacterial Disease Research Disease Research Fields	Bacterial Antibiotic
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of *P-glycoprotein* and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus .

HY-N13157

11α-O-Benzoyl-12β-O-acetyltenacigenin B	Structural Classification Natural Products Marsdenia tenacissima (Roxb.) Moon Source classification Asclepiadaceae Plants	P-glycoprotein
11α-O-Benzoyl-12β-O-acetyltenacigenin B is a P-glycoprotein (Pgp) inhibitor derived from Marsdenia tenacissima and belongs to the Tenacigenin B (HY-N1168) derivatives. 11α-O-Benzoyl-12β-O-acetyltenacigenin B can inhibit multidrug resistance (MDR) caused by P-glycoprotein (Pgp) overexpression in HepG2/Dox cells and holds potential for research in the field of cancer .

HY-N2103

Tenacissoside G	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	P-glycoprotein
Tenacissoside G is a C21 steroid from the stems of Marsdenia tenacissima. Tenacissoside G reverses multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells .

HY-W143403A

(-)-Isopinocampheol l-Isopinocampheol	Structural Classification Other Monoterpenes Terpenoids Labiatae Source classification Plants	Filovirus
(-)-Isopinocampheol (l-Isopinocampheol) is a compound with anti-filovirus activity. Its derivatives inhibit infection by Ebola virus and Marburg virus, possibly through binding to surface glycoproteins. It also has lysosomal affinity.

HY-N6932

Voacamine	Alkaloids Structural Classification other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields Indole Alkaloids	Cannabinoid Receptor P-glycoprotein
Voacamine, an indole alkaloid, exhibits potent cannabinoid CB1 receptor antagonistic activity . Voacamine also inhibits *P-glycoprotein* (P-gp) action in multidrug-resistant tumor cells .

HY-N1916

Coniferyl ferulate	Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Dicerothamnus rhinocerotis Phenylpropanoids Umbelliferae Plants Disease Research Fields Cancer	Glutathione S-transferase P-glycoprotein
Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST), reverses multidrug resistance and downregulates P-glycoprotein. Coniferyl ferulate shows strong inhibition of human placental GST with an IC50 of 0.3 μM.

HY-N10491

Spongionellol A	Microorganisms Source classification Diterpenoids	P-glycoprotein
Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A can be used in the research of cancers, such as prostate cancer .

HY-N6684

Deoxynivalenol 5+ Cited Publications Vomitoxin	Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Disease Research Fields	P-glycoprotein
Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-113044

Uridine diphosphate glucose	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite P2Y Receptor
Uridine diphosphate glucose is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine diphosphate glucose is an agonist of the P2Y₁₄ receptor, a neuroimmune system GPCR ^1.

HY-N11287

UDP-xylose	Structural Classification Alkaloids Microorganisms Source classification	Endogenous Metabolite
UDP-xylose is a natural product that could be isolated from Cryptococcus laurentii (NRRL Y-1401). UDP-xylose is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites, and oligosaccharides in plants, vertebrates, and fungi .

HY-N0144

Piperine 10+ Cited Publications Bioperine; 1-Piperoylpiperidine	Structural Classification Classification of Application Fields Source classification Piperaceae Plants Endogenous metabolite Piper nigrum Linn. Biological Pesticide Research Agricultural Research Alkaloids Piperidine Alkaloids Disease Research Fields Cancer	P-glycoprotein Autophagy Endogenous Metabolite
Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of *P-glycoprotein* and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-N4108

Hypophyllanthin	Phyllanthus urinaria Linn. Structural Classification Classification of Application Fields Source classification Lignans Euphorbiaceae Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	P-glycoprotein
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits *P-glycoprotein* (P-gp)** activity and did not interfere with multidrug resistance protein 2 (MRP2) activity .

HY-N10633

LSTc LS-tetrasaccharide c	Infection Structural Classification Polysaccharides Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Cancer	Others
LSTc (LS-tetrasaccharide c) is a human lactooligosaccharide presents on glycoproteins and glycolipids. LSTc is also a specific human JC polyomavirus (JCV) recognition motif. LSTc has good potential for the study of progressive multifocal leukoencephalopathy (PML) .

HY-19332

Kifunensine 5+ Cited Publications FR-900494	Alkaloids Piperidine Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Glycosidase
Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .

HY-N3197

Neostenine (+)-Neostenine	Structural Classification Alkaloids Pyrrole Alkaloids Stemonaceae Other Alkaloids Source classification Plants Stemona sesslifolia	P-glycoprotein
Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of *P-glycoprotein* with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application .

HY-P3160

Fibronectin 3 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Integrin
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .

HY-N3085

Phellamurin	Flavanonols Phellodendron amurense Rupr. Flavonoids Classification of Application Fields Source classification Rutaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	P-glycoprotein Apoptosis
Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal *P-glycoprotein. Phellamurin also inhibits egg laying by Papilio protenor. Phellamurin induces cells apoptosis* and has anti-tumor activity .

HY-N5166

Ardeemin (-)-Ardeemin	Structural Classification Alkaloids Microorganisms Source classification Indole Alkaloids	P-glycoprotein
Ardeemin ((-)-Ardeemin) binds to the P-glycoprotein, preventing anticancer agent from being pumped out of cells. Ardeemin reverses the multidrug resistance phenotype of tumor cells and increases the sensitivity of tumor cells to anticancer agent in mammary carcinoma xenografts .

HY-N11287A

UDP-xylose disodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
UDP-xylose disodium is a natural product that could be isolated from Cryptococcus laurentii (N RRL Y-1401). UDP-xylose disodium is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites, and oligosaccharides in plants, vertebrates, and fungi ..

HY-N10562

Mutabilol	Terpenoids Labiatae Smallanthus uvedalia (Linnaeus) Mackenzie Diterpenoids Plants	P-glycoprotein
Mutabilol (compound 1) is a potent *p-glycoprotein* (P-gp)** regulator. Mutabilol is a nature product could be isolated from Plectranthus mutabilis leaves. Mutabilol increases the P-gp expression in NCI-H460/R cells .

HY-147063R

N-Acetyl-α-D-glucosamine 1-phosphate (disodium) (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
Indole (Standard) is the analytical standard of Indole. This product is intended for research and analytical applications. Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule .

HY-W009141R

1-Monopalmitin (Standard)	Source classification Plants	P-glycoprotein
1-Monopalmitin (Standard) is the analytical standard of 1-Monopalmitin. This product is intended for research and analytical applications. 1-Monopalmitin, a bitter melon extract, inhibits the P-glycoprotein (P-gp) activity in intestinal Caco-2 cells .

HY-N2947

Boeravinone B	Structural Classification Natural Products other families Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	P-glycoprotein
Boeravinone B, a dual inhibitor of NorA bacterial efflux pump of Staphylococcus aureus and human P-Glycoprotein, reduces the biofilm formation and intracellular invasion of bacteria. Boeravinone B act as anti-aging and anti-apoptosis phyto-molecules during oxidative stress .

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Structural Classification Natural Products Animals Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Endogenous Metabolite
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation .

HY-126940

Furanodiene	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Curcuma longa Disease Research Fields Cancer Zingiberaceae	Reactive Oxygen Species P-glycoprotein Apoptosis
Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level .

HY-N6684R

Deoxynivalenol (Standard)	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	P-glycoprotein
Deoxynivalenol (Standard) is the analytical standard of Deoxynivalenol. This product is intended for research and analytical applications. Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-N11422R

Mycaminosyltylonolide (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research	Antibiotic Bacterial
Deoxynivalenol (Standard) is the analytical standard of Deoxynivalenol. This product is intended for research and analytical applications. Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .

HY-N4108R

Hypophyllanthin (Standard)	Phyllanthus urinaria Linn. Structural Classification Source classification Lignans Euphorbiaceae Phenylpropanoids Plants	P-glycoprotein
Hypophyllanthin (Standard) is the analytical standard of Hypophyllanthin. This product is intended for research and analytical applications. Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity .

HY-N0692

Schisandrol B 2 Publications Verification Gomisin-A; TJN-101; Wuweizi alcohol-B	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Cancer	Reactive Oxygen Species Cytochrome P450 Autophagy
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of *P-glycoprotein* and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-N10492

Spongionellol A analog 1	Microorganisms Source classification Diterpenoids	P-glycoprotein
Spongionellol A analog 1, an analog of Spongionellol A (HY-10491), is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A analog 1 has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A analog 1 can be used in the research of cancers, such as prostate cancer .

HY-N0144R

Piperine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Source classification Piperaceae Plants Endogenous metabolite Piper nigrum Linn.	P-glycoprotein Autophagy Endogenous Metabolite
Piperine (Standard) is the analytical standard of Piperine. This product is intended for research and analytical applications. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-N3028

Taccalonolide B	Structural Classification Classification of Application Fields Source classification Schizocapsa plantaginea Hance Plants Disease Research Fields Taccaceae Steroids Cancer	Microtubule/Tubulin
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC₅₀ of 208 nM .

HY-126854

N-Acetyllactosamine N-Acetyl-D-lactosamine	Structural Classification Natural Products Microorganisms	Endogenous Metabolite Galectin
N-Acetyllactosamine (N-Acetyl-D-lactosamine), a nitrogen-containing disaccharide, is a galectin-3 inhibitor, which is an important component of various oligosaccharides such as glycoproteins and sialyl Lewis X. N-Acetyllactosamine can be used as the starting material for the synthesis of various oligosaccharides. N-Acetyllactosamine has prebiotic effects .

HY-N0069

Solamargine 10+ Cited Publications Solamargin; δ-Solanigrine	Structural Classification Alkaloids Piperidine Alkaloids Solanum Classification of Application Fields Solanaceae Plants Disease Research Fields Saccharides Steroids Cancer	P-glycoprotein Apoptosis
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and *P-glycoprotein* inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity .

HY-113044R

Uridine diphosphate glucose (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	P2Y Receptor Endogenous Metabolite
Uridine diphosphate glucose (Standard) is the analytical standard of Uridine diphosphate glucose. This product is intended for research and analytical applications. Uridine diphosphate glucose is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine diphosphate glucose is an agonist of the P2Y₁₄ receptor, a neuroimmune system GPCR .

HY-N2947R

Boeravinone B (Standard)	Structural Classification Natural Products other families Source classification Phenols Polyphenols Plants	P-glycoprotein
Boeravinone B (Standard) is the analytical standard of Boeravinone B. This product is intended for research and analytical applications. Boeravinone B, a dual inhibitor of NorA bacterial efflux pump of Staphylococcus aureus and human P-Glycoprotein, reduces the biofilm formation and intracellular invasion of bacteria. Boeravinone B act as anti-aging and anti-apoptosis phyto-molecules during oxidative stress .

HY-125918

Bleomycin A5 hydrochloride Pingyangmycin hydrochloride	Structural Classification Microorganisms Antibiotics Source classification	Apoptosis Antibiotic
Bleomycin A5 (Pingyangmycin) hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1-mediated mitochondrial fission and induces apoptosis in human nasal polyp-derived fibroblasts. Bleomycin A5 hydrochloride has anticancer activities relying on its ability to produce RNA and DNA breaks, thus, leading to cell death ..

HY-N0639

Punicalin	Structural Classification Punica granatum L. Classification of Application Fields Source classification Phenols Polyphenols Punicaceae Plants Inflammation/Immunology Disease Research Fields	HBV Pyroptosis Carbonic Anhydrase
Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of *S-glycoprotein* and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity .

HY-W415798

Ac4GalNAlk	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .

HY-147089

PRRSV/CD163-IN-1	Infection Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Bacterial Endogenous Metabolite
PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor. PRRSV/CD163-IN-1 can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. PRRSV/CD163-IN-1 can be used for the research of porcine reproductive and respiratory syndrome (PRRS) .

Cat. No.	Product Name	Chemical Structure

HY-135328AS

Norverapamil-d7 hydrochloride
Norverapamil-d₇ (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-110232

Risperidone-d4
Risperidone-d₄ is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.

HY-135328S

Norverapamil-d7
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-W699430

Norverapamil-d6 hydrochloride
Norverapamil-d₆ ((±)-Norverapamil-d₆) hydrochloride is deuterium labeled Norverapamil (hydrochloride). Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a *P-glycoprotein* (P-gp)** function inhibitor .

HY-W654320

Piperin-d10
Piperin-d₁₀ is deuterium labeled Piperine. Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of *P-glycoprotein* and CYP3A4. Piperine inhibits HeLa cells with an IC₅₀ of 61.94±0.054 μg/mL .

HY-W702292

(R)-(+)-Verapamil-d6 hydrochloride
(R)-(+)-Verapamil-d₆ (hydrochloride) is deuterium labeled (R)-Verapamil (hydrochloride). (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a *P-Glycoprotein* inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents .

HY-135336S

(R)-Verapamil-d7 hydrochloride
(R)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents[1][2].

HY-108286S

(Rac)-Talinolol-d5
(Rac)-Talinolol-d₅ is the racemate of Talinolol. Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity[1][2][3].

HY-A0064S

Verapamil-d3 hydrochloride

Verapamil-d₃ (hydrochloride) is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].

HY-14275S1

Verapamil-d7
Verapamil-d₇ is the deuterium labeled Verapamil (HY-14275). Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation *P-glycoprotein* (P-gp) inhibitor. Verapamil also inhibits CYP3A4**. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research .

HY-11018S2

Risperidone-d6
Risperidone-d6 (R 64 766-d6) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively .

HY-11018S1

Risperidone-d4-1
Risperidone-d4-1 (R 64 766-d4-1) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT₂ receptor blocker, *P-Glycoprotein* inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively.

HY-A0064S1

Verapamil-d6 hydrochloride

Verapamil-d₆ (CP-16533-1-d₆) hydrochloride is the deuterium labled Verapamil (hydrochloride) (HY-A0064). Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research .

HY-N7032S1

Uridine 5′-diphosphoglucose-13C6 disodium

Uridine 5′-diphosphoglucose- ¹³C₆ (disodium) is the ¹³C labeled Uridine 5′-diphosphoglucose disodium salt[1]. Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR[2].

HY-B0532AS

Trifluoperazine-d3 dihydrochloride

Trifluoperazine-d₃ (dihydrochloride) is deuterium labeled Trifluoperazine (dihydrochloride). Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].

HY-17367S4

Atazanavir-d6
Atazanavir-d₆ is deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S3

Atazanavir-d5
Atazanavir-d₅ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S2

Atazanavir-d9
Atazanavir-d₉ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-B0777S

Moxidectin-d3

Moxidectin-d₃ (CL-301423-d₃) is deuterium labeled Moxidectin. Moxidectin (CL301423) is an orally active macrolide (ML) anthelmintic for the prevention and control of heartworms and roundworms. Moxidectin is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite mediated by Bcrp1 and P-gp. This may be related to the presence of chemical residues in milk .

HY-15206S

Glyburide-d11

Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206S1

Glyburide-d3

Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

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