Search Result

Pathways Recommended:	Autophagy

Results for "

autophagy

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Atg4 (4) Atg8/LC3 (18) AUTACs (8) Autophagy (645) AUTOTACs (9) Mitophagy (40) 11β-HSD (1) 5-HT Receptor (3) ADC Cytotoxin (8) Adenylate Cyclase (2) Adiponectin Receptor (1) Adrenergic Receptor (10) Akt (38) AMPK (30) Amyloid-β (5) Anaplastic lymphoma kinase (ALK) (4) Androgen Receptor (9) Antibiotic (41) Apoptosis (323) Aryl Hydrocarbon Receptor (1) Atg7 (3) ATTECs (1) Aurora Kinase (2) Bacterial (48) Bcl-2 Family (24) Bcr-Abl (4) Beclin1 (8) Beta-lactamase (1) Beta-secretase (1) Biochemical Assay Reagents (1) Btk (1) c-Met/HGFR (3) c-Myc (2) Calcium Channel (11) CaMK (1) Casein Kinase (1) Caspase (19) Cathepsin (4) CDK (6) CFTR (4) Cholinesterase (ChE) (1) COX (5) CRISPR/Cas9 (1) Cyclin G-associated Kinase (GAK) (1) Cyclophilin (3) Cytochrome P450 (10) Dengue virus (1) Deubiquitinase (4) Dipeptidyl Peptidase (3) Discoidin Domain Receptor (2) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (3) DNA-PK (2) DNA/RNA Synthesis (6) Dopamine Receptor (5) Dopamine Transporter (1) Drug Metabolite (9) DYRK (1) E1/E2/E3 Enzyme (3) EBV (1) EGFR (17) Endogenous Metabolite (47) Epigenetic Reader Domain (3) ERK (12) Estrogen Receptor/ERR (13) Eukaryotic Initiation Factor (eIF) (1) FAK (6) Ferroptosis (19) Filovirus (2) FKBP (6) Flavivirus (1) FLT3 (7) Fluorescent Dye (4) Fungal (23) FXR (5) GABA Receptor (1) Glucosidase (6) Glutaminase (2) Glutathione Peroxidase (3) Glutathione S-transferase (1) GSK-3 (7) HBV (6) HCV (1) HDAC (18) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (11) Histamine Receptor (1) Histone Acetyltransferase (1) Histone Methyltransferase (6) HIV (38) HIV Protease (2) HSP (10) HSV (5) ICMT (1) IGF-1R (1) IKK (5) Imidazoline Receptor (4) Influenza Virus (8) Integrin (2) Interleukin Related (4) Isotope-Labeled Compounds (41) JAK (7) JNK (12) Keap1-Nrf2 (9) Kinesin (1) Ligands for Target Protein for PROTAC (2) Liposome (1) Lipoxygenase (2) LPL Receptor (3) MDM-2/p53 (8) MEK (11) Microtubule/Tubulin (21) Mineralocorticoid Receptor (5) Mitochondrial Metabolism (8) MMP (8) Monoamine Oxidase (2) mTOR (47) Myosin (2) Na+/H+ Exchanger (NHE) (2) NAMPT (3) Necroptosis (4) NF-κB (17) NO Synthase (6) NOD-like Receptor (NLR) (5) Notch (1) Nuclear Hormone Receptor 4A/NR4A (3) Nucleoside Antimetabolite/Analog (8) Organoid (18) Orthopoxvirus (2) Oxidative Phosphorylation (7) P-glycoprotein (6) P2X Receptor (2) p38 MAPK (12) p62 (17) Paraptosis (2) Parasite (35) PARP (14) PDHK (1) PDK-1 (2) PERK (3) Phosphatase (5) Phosphodiesterase (PDE) (1) Phospholipase (3) PI3K (25) PIKfyve (2) Pim (4) PKA (2) PKC (9) Polo-like Kinase (PLK) (2) Potassium Channel (8) PPAR (1) Prostaglandin Receptor (2) PROTAC Linkers (1) PROTACs (6) Proteasome (4) Proton Pump (3) PTEN (1) Pyroptosis (4) RABV (1) RAD51 (2) Raf (11) RANKL/RANK (1) RAR/RXR (6) Ras (4) Reactive Oxygen Species (49) REV-ERB (2) Reverse Transcriptase (7) RIP kinase (2) ROCK (1) ROS Kinase (1) SARS-CoV (11) Serotonin Transporter (9) SGK (1) Sirtuin (3) SOD (1) SphK (6) Src (7) STAT (10) Survivin (1) Syk (2) TGF-β Receptor (3) Thymidylate Synthase (2) TNF Receptor (9) Toll-like Receptor (TLR) (16) Topoisomerase (11) Trk Receptor (1) TRP Channel (5) ULK (17) VEGFR (9) Wnt (5) Xanthine Oxidase (1) YAP (5) α-synuclein (3) β-catenin (7) γ-secretase (1)
By Research Areas:	Cancer (610) Cardiovascular Disease (73) Endocrinology (17) Infection (120) Inflammation/Immunology (151) Metabolic Disease (83) Neurological Disease (121)
Oligonucleotides:	Decoy ODNs (1) Cosolvents (1) Pegylated Lipids (1) pH Modifiers (1)

789

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

212

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Autophagy inducer 3	Atg8/LC3 Autophagy	Cancer
Autophagy inducer 3 has *autophagy* induced activity. Autophagy inducer 3 possesses robust autophagic cell death in diverse cancer cells sparing normal counterpart. Autophagy inducer 3 induces lethal autophagy by formation of characteristic autophagic vacuoles, LC3 puncta formation, upregulation of signature autophagy markers like Beclin and Atg family proteins .

Autophagy-IN-6	Autophagy	Cancer
Autophagy-IN-6 (compound 1u) is a lysosomotropic *autophagy* inhibitor and can induces LC3-II protein accumulation. Autophagy-IN-6 shows anti-proliferative activity .

Autophagy/REV-ERB-IN-1 hydrochloride	Autophagy REV-ERB	Cancer
Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) is a dual autophagy and REV-ERB inhibitor with anticancer activity. Autophagy/REV-ERB-IN-1 (hydrochloride) has improved potency in blocking autophagy, enhanced toxicity against cancer cells. Autophagy/REV-ERB-IN-1 (hydrochloride) can be used for the research for melanoma .

Autophagy/REV-ERB-IN-1	Autophagy REV-ERB	Cancer
Autophagy/REV-ERB-IN-1 (compound 24) is a dual inhibitor of *autophagy* and REV-ERB. Autophagy/REV-ERB-IN-1 has anti-tumor activity with a CC₅₀ value of 2.3 μM on BTB-474 cells.

Autophagy inducer 2	Apoptosis Autophagy	Cancer
Autophagy inducer 2 (Compound 11i) is a potent autophagy inducer. Autophagy inducer 2 exhibits apparent antiproliferative activity against the MCF-7 cell line with an IC₅₀ value of 1.31 μM and remarkably inhibits the colony formation of the MCF-7 cells. Autophagy inducer 2 arrests the MCF-7 cells in the G2/M phase by regulating the cell-cycle-related proteins Cdk-1 and Cyclin B1. Autophagy inducer 2 has the potential for the research of breast cancer .

Autophagy-IN-3	Autophagy	Cancer
Autophagy-IN-3 (Compound 6k) is an *autophagy* inhibitor. Autophagy-IN-3 promotes metabolic stress in the tumor microenvironment and enhances the effects of cytostatics in combined treatments .

Autophagy-IN-1	Autophagy Apoptosis	Cancer
Autophagy-IN-1 is a potent *autophagy/mitophagy* inhibitor, acts by selectively increasing the autophagic flux while blocking the autophagosome-lysosome fusion in cancer cells. Autophagy-IN-1 can induce apoptosis and cell cycle arrest. Autophagy-IN-1 significantly inhibits tumor growth in an HCT116 xenograft mouse model and with low toxicity. Autophagy-IN-1 can be used for researching colorectal cancer .

Autophagy-IN-5	Autophagy	Inflammation/Immunology Cancer
Autophagy-IN-5 (Compound A9) is an inhibitor for *autophagy* with an EC₅₀ of 0.736 μM .

Autophagy-IN-4	Autophagy	Cancer
Autophagy-IN-4 (Compound 34) is an *autophagy* inhibitor, with an EC₅₀ of 0.5 μM and a LD50 of 27 μM for U2OS cells .

Autophagy-IN-C1	Autophagy	Cancer
Autophagy-IN-C1 not only induces apoptosis but also blocks *autophagy* in hepatocellular carcinoma (HCC) cells.

Autophagy-IN-2	Autophagy Apoptosis	Cancer
Autophagy-IN-2 (Compound 7h) is an autophagic flux inhibitor. Autophagy-IN-2 induces cancer cell apoptosis and can be used for triple-negative breast cancer research .

Autophagy inducer 4	Autophagy	Cancer
Autophagy inducer 4 is a Magnolol-based Mannich base derivatives, which can be used as an anticancer agent. Autophagy inducer 4 suppresses cancer cells via inducing *autophagy. Autophagy* inducer 4 has 76-fold improvement in cytotoxicity against T47D cells compared with Magnolol. Autophagy inducer 4 also possesses suppressive effects on migration of T47D and Hela cancer cells .

Autophagy inducer 5	Autophagy JNK Reactive Oxygen Species	Cancer
Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC₅₀: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the ROS/JNK signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects .

AUTEN-67 autophagy enhancer-67	Autophagy	Neurological Disease
AUTEN-67 (Autophagy enhancer-67) is an orally active *autophagy* enhancer and MTMR14 inhibitor. AUTEN-67 has anti-aging and neuroprotective effects. AUTEN-67 protects neurons from stress-induced cell death. AUTEN-67 also restores nesting behavior in a mice model of Alzheimer disease .

AUTEN-67 inner salt autophagy enhancer-67 inner salt	Autophagy	Neurological Disease
AUTEN-67 (inner salt), the inner salt form of AUTEN-67 (HY-117924), is an orally active *autophagy*-enhancing agent and MTMR14 inhibitor with potent antiaging and neuroprotective effects. AUTEN-67 (inner salt) hampers the progression of neurodegenerative symptoms in a drosophila model of Huntington's disease .

AUTEN-99 hydrobromide autophagy enhancer-99 hydrobromide	Others	Neurological Disease
AUTEN-99 (hydrobromide) is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14). AUTEN-99 (hydrobromide) crosses the blood-brain barrier and exerts potent neuroprotective effects .

Corynoxine B 3 Publications Verification	Autophagy Beclin1 α-synuclein	Neurological Disease Cancer
Corynoxine B is a natural alkaloid and autophagy inducer that can improve Mn induced cellular autophagy dysregulation and enhance clearance of alpha synuclein (alpha syn) in Parkinson's disease mice ^[1][3].

SG31	Autophagy	Cancer
SG31 is a potent *autophagy* activator via the AMPK/ULK1-dependent pathway .

T-271	Mitophagy	Neurological Disease
T-271 is a selective inducer of mitochondrial autophagy .

Corynoxine B (Standard)	Autophagy Beclin1 α-synuclein	Neurological Disease Cancer
Corynoxine B (Standard) is the analytical standard of Corynoxine B. This product is intended for research and analytical applications. Corynoxine B is a natural alkaloid and autophagy inducer that can improve Mn induced cellular autophagy dysregulation and enhance clearance of alpha synuclein (alpha syn) in Parkinson's disease mice .

4,4'-Dimethoxychalcone	Autophagy	Metabolic Disease
4,4'-Dimethoxychalcone acts as a natural *autophagy* inducer with anti-ageing properties .

MJO445	Atg4 Autophagy	Cancer
MJO445 (Compound 7) is a ATG4B inhibitor, which inhibits the autophagy of glioblastoma .

Clionamine B	Autophagy	Cancer
Clionamine B is an autophagy stimulating aminosteroid isolated from the sponge Cliona celata. Clionamine B strongly stimulates autophagy in human breast cancer MCF-7 cells .

ARL 17477	NO Synthase	Cancer
ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers .

Malvidin-3-O-arabinoside chloride	AMPK Autophagy	Metabolic Disease Inflammation/Immunology
Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated *autophagy* .

Vps34-IN-4	PI3K Autophagy	Cancer
Vps34-IN-4 (compound 19) is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components .

Cearoin	Autophagy Reactive Oxygen Species ERK Apoptosis	Cancer
Cearoin increases *autophagy* and apoptosis through the production of ROS and the activation of ERK .

AUTAC4 2 Publications Verification	AUTACs Mitophagy	Neurological Disease Cancer
AUTAC4 is a mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC4 downregulates cytosolic proteins and promotes targeted mitochondrial turnover via mitophagy .

CXM102	Autophagy	Metabolic Disease
CXM102 is an *autophagy* activator. CXM102 can induce autophagy in aged BMSCs, leading to the rejuvenation of BMSCs and preferential differentiation into osteoblasts. CXM102 promotes the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. CXM102 can stimulate bone synthesis metabolism in middle-aged male mice, reduce bone marrow adipocytes, delay bone loss, lower serum inflammation levels, decrease organ fibrosis, and extend the lifespan of the mice .

Anticancer agent 161	Others	Cancer
Anticancer agent 161 (Compound 3b) is a bioactive alkynol with anti-cancer potential. Anticancer agent 161 can trigger autophagy and mitochondrial membrane potential depletion .

mTOR inhibitor-8	mTOR Autophagy	Cancer
mTOR inhibitor-8 is an mTOR inhibitor and *autophagy* inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells .

UCM-1336	Apoptosis Autophagy	Cancer
UCM-1336 is a potent ICMT inhibitor, with an IC₅₀ of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by *autophagy* and apoptosis .

MR-2088	ULK Autophagy	Cancer
MR-2088 is a selective ULK1/ULK2 inhibitor with pEC₅₀ values of 8.3 and 8.7, respectively. MR-2088 selectively inhibits *autophagy* through ULK1/2 mediated inhibition .

GA001	Histone Methyltransferase Autophagy Apoptosis	Cancer
GA001 is a potent G9a antagonist, with an IC₅₀ of 1.32 μM. GA001 induces *autophagy* and apoptosis that can be used for the breast cancer .

Sarmentosin Sarmentosine; Sarmentosine (glycoside)	Keap1-Nrf2 mTOR Apoptosis	Cancer
Sarmentosin is an activator of Nrf2. Sarmentosin inhibits mTOR signaling and induces autophagy-dependent apoptosis in human HCC cells .

MHY1485 120+ Cited Publications	mTOR Autophagy	Cancer
MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR. MHY1485 inhibits *autophagy* by suppression of fusion between autophagosomes and lysosomes .

Norswertianin	Autophagy	Cancer
Norswertianin, a xanthone compound, serves as a powerful anti-glioma compound. Norswertianin induces GBM cells differentiation through oxidative stress and Akt/mTOR dependent autophagy .

Thioether-cyclized helix B peptide, CHBP	mTOR	Others
Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing *autophagy* via inhibition of mTORC1 and activation of mTORC2 .

Isodunnianol	Autophagy	Cardiovascular Disease
Isodunnianol is a autophagy inducer. Isodunnianol induces *autophagy* and increases he expression of pAMPK172, pULK1555,decreases teh expression of pULK1757, SQSTM2. Isodunnianol decreases Doxorubicin (HY-15142A)-induced cardiotoxicity .

Anticancer agent 251	Apoptosis Autophagy Ferroptosis	Cancer
Anticancer agent 251 (compound 7j) can induce cell death of bladder cancer cell T24 by inducing apoptosis, autophagy or ferroptosis .

NAMPT degrader-1	NAMPT Autophagy	Cancer
NAMPT degrader-1 (Compound A3) is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC₅₀ of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the **autophagy-lysosomal pathway and shows excellent cellular antitumor potency .**

AUTAC1	AUTACs Autophagy	Metabolic Disease Cancer
AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2 .

Microcolin H	Autophagy p62 Atg8/LC3	Cancer
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models .

C16 PEG2000 Ceramide C16 PEG Ceramide (MW 2000)	Liposome Autophagy	Cancer
C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide. C16 PEG2000 Ceramide can be used for lipid carrier to delivery. C16 PEG2000 Ceramide induces *autophagy*. C16 PEG2000 Ceramide can be used for cancer research .

XIE62-1004-A	Autophagy p62 Atg8/LC3	Others
XIE62-1004-A is an inducer of p62-LC3 interaction. XIE62-1004-A can bind to the ZZ-domain of p62, inducing p62 oligomerization and activating p62-dependent *autophagy* .

Glychionide A	Apoptosis Autophagy	Cancer
Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and *autophagy* of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer .

Cat. No.	Product Name

HY-L029

Autophagy Compound Library

1,435 compounds

Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease.

MCE provides a unique collection of 1,435 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

HY-L180

Mitophagy Compound Library

604 compounds

Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms.

MCE can provide a library of 604 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

HY-L155

Mitochondrial Toxicity Compound Library

486 compounds

Mitochondria, as the main place of energy supply in life, is essential to maintain normal life activities. Mitochondrial dysfunction is associated with common diseases, such as cardiovascular diseases, neurodegenerative diseases, diabetes and cancer. The heart, brain and liver rely heavily on mitochondrial function as the main organs for drug metabolism. In addition, mitochondria is also a target of many drugs, some of which induce organotoxicity by inducing mitochondrial toxicity.

MCE contains 486 mitochondrial toxic compounds, which can be used as tool compounds for drug development and disease mechanism research.

HY-L051

Ferroptosis Compound Library

1,009 compounds

Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

MCE carefully collected a unique collection of 1,009 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

Cat. No.	Product Name	Type

HY-D1594

BODIPY TR Cadaverine 1 Publications Verification	Fluorescent Dyes/Probes
BODIPY TR Cadaverine, a cadaverine derivative, is a red fluorescent dye. BODIPY TR Cadaverine can be used in a a highly sensitive and robust fluorescent displacement assay, which binds to native LPS strongly, specifically recognizing lipid A, and is competitively displaced by compounds displaying an affinity for lipid A .

HY-D2227

IR-58	Fluorescent Dyes/Probes
IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an *autophagy* enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS)-Akt-mTOR pathway .

Cat. No.	Product Name	Type

HY-W016412

Coenzyme Q0

2 Publications Verification

CoQ0

Enzyme Substrates

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

HY-144005

C16 PEG2000 Ceramide C16 PEG Ceramide (MW 2000)	Drug Delivery
C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide. C16 PEG2000 Ceramide can be used for lipid carrier to delivery. C16 PEG2000 Ceramide induces *autophagy*. C16 PEG2000 Ceramide can be used for cancer research .

HY-NP131

Recombinant Humanized Type III Collagen (30-40kDa)	Native Proteins
Recombinant Humanized Type III Collagen 30-40kDa is a novel biomaterial that have anticancer effects. Recombinant Humanized Type III Collagen 30-40kDa activates discoidin domain receptor 1 (DDR1), and thus inhibits *autophagy, proliferation, and migration of cancer cells, and induces apoptosis* .

HY-113596A

Acetyl coenzyme A lithium

Acetyl-CoA lithium

Drug Delivery

Acetyl-coenzyme A (Acetyl-CoA) lithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A lithium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A lithium is also a key precursor of lipid synthesis .

HY-W782399

CORM-A1

Sodium boranocarbonate

Biochemical Assay Reagents

CORM-A1 (Sodium boranocarbonate) is a water-soluble carbon monoxide (CO) releasing molecule that facilitates the investigation of CO's impact on cellular systems. As CO is generated from heme degradation by the enzyme heme oxygenase, it serves as a crucial gaseous signaling mediator in mammalian cells. CORM-A1 not only exhibits anti-oxidant and anti-inflammatory properties but also regulates CO release in a manner dependent on pH and temperature, promoting mild vasorelaxation and hypotension. Furthermore, CORM-A1 has been shown to provide cytoprotection in primary cultures of astrocytes under oxidative stress while also enhancing autophagy due to its boron-containing composition.

Cat. No.	Product Name	Target	Research Area

HY-105037A

Forigerimod TFA IPP-201101 TFA	Autophagy	Inflammation/Immunology
Forigerimod TFA (IPP-201101 TFA) is a CD4 T-cell modulator. Forigerimod TFA is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod TFA can potently inhibit *autophagy*. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) .

HY-P2260

Tat-beclin 1 1 Publications Verification	Autophagy HIV	Infection
Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of *autophagy* and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .

HY-P2260B

Tat-beclin 1 scrambled	HIV	Infection
Tat-beclin 1 scrambled is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces *autophagy* via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus .

HY-P5984

Thioether-cyclized helix B peptide, CHBP	mTOR	Others
Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing *autophagy* via inhibition of mTORC1 and activation of mTORC2 .

HY-163001

Microcolin H	Autophagy p62 Atg8/LC3	Cancer
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models .

HY-P5984A

Thioether-cyclized helix B peptide, CHBP TFA	mTOR	Others
Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing *autophagy* via inhibition of mTORC1 and activation of mTORC2 .

HY-P3148

Astin B	p62 Atg8/LC3 Apoptosis Autophagy Reactive Oxygen Species JNK Bcl-2 Family Caspase	Metabolic Disease
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces *autophagy* in L-02 cells, increases LC3-II and decreases p62 expression .

HY-105037

Forigerimod IPP-201101	Autophagy	Inflammation/Immunology
Forigerimod (IPP-201101) is a CD4 T-cell modulator. Forigerimod is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod can potently inhibit *autophagy*. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) .

HY-P10343

Soybean peptide QRPR	Autophagy	Inflammation/Immunology
Soybean peptide QRPR is an agonist of *Autophagy. Soybean peptide QRPR activates cellular autophagy* by upregulating the expression and activity of PIK3, AKT, and mTOR. Soybean peptide QRPR can reduce the inflammatory response .

HY-P2260A

Tat-beclin 1 TFA	Autophagy HIV	Infection
Tat-beclin 1 TFA, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of *autophagy* and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 TFA decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .

HY-P2260C

Tat-beclin 1 scrambled TFA	HIV	Infection
Tat-beclin 1 scrambled TFA is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces *autophagy* via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus .

HY-P10110

retro-inverso TAT-Beclin 1 (D-amino acid)	Autophagy	Neurological Disease
retro-inverso TAT-Beclin 1 D-amino acid is has higher activity and resistance to proteolytic degradation in vivo compared to L-amino acids peptide. TAT-Beclin 1 can induce *autophagy* in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice .

HY-P10416

Q14 Q14 peptide	Deubiquitinase Mitophagy	Others Neurological Disease
Q14 is a polypeptide derived from the USP30 (ubiquitin specific peptidase 30) transmembrane (TM) domain with the ability to inhibit the deubiquitination activity of USP30 (IC₅₀=57.2 nM). Q14 reduces USP30 activity by inhibiting the interaction between the USP30 transmembrane domain and its catalytic domain. Q14 peptide contains the LC3 interaction region (LIR) motif, which enables it to bind to the LC3 and accelerate the formation of autophagosomes, thereby promoting mitophagy. Q14 can be used in the study of neurodegenerative diseases as well as mitochondrial quality control and cell metabolism .

HY-P1098B

Ac2-26 ammonium 4 Publications Verification	IKK	Inflammation/Immunology
Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model .

HY-164388

Z-VAD	Caspase Apoptosis Autophagy Necroptosis	Cardiovascular Disease Cancer
Z-VAD is a competitive, irreversible pan-caspase inhibitor. Z-VAD inhibits all 10 caspases, except for caspase-2 which is only weakly inhibited. Z-VAD decreases radiation-induced apoptosis. Z-VAD induces both *autophagy* and necrosis in irradiated MDA-MB-231 and H460 mouse xenografts. Z-VAD with radiation produces a significant tumor growth delay and shows dramatic antiangiogenic effect in cancer xenograft .

Cat. No.	Product Name	Target	Research Area

HY-152228

SMYD3-IN-2	Histone Methyltransferase Autophagy	Cancer
SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal *autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC₅₀* values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer .

Species:	Human (9)
Tag:	His (4) Tag Free (3) Myc (1) GST (1) MBP (1) Flag (2)
Source:	HEK293 (2) Sf9 insect cells (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P71576

	ATG14 Protein, Human (Myc, His) 4832427M01; ATG14; Atg14L; autophagy-related protein 14-like protein; Barkor; Beclin 1-associated autophagy-related key regulator; D14Ertd114e	Human	E. coli
	ATG14 is critical for basal and induced autophagy, determining PI3KC3-C1 localization, helping autophagosome formation and BECN1 translocation. It enhances PIK3C3 activity in a BECN1-dependent manner, which is essential for BECN1 phosphorylation. ATG14 Protein, Human (Myc, His) is the recombinant human-derived ATG14 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

HY-P7620

	ATG5 Protein, Human rHuATG5; autophagy protein 5; APG5-like; Apoptosis-specific protein; APG5L; ASP; ATG5;	Human	E. coli
	ATG5 is an important participant in the formation of autophagy vesicles and binds to ATG12 through a ubiquitin-like system, which is critical for the lipidation of ATG8 family proteins. It plays a crucial role in mitochondrial quality control, affects cell longevity, and is critical for lymphocyte development, antigen processing, axonal morphology maintenance, adipocyte differentiation, primary ciliogenesis, and apoptotic processes. ATG5 Protein, Human is the recombinant human-derived ATG5 protein, expressed by E. coli , with tag free. The total length of ATG5 Protein, Human is 275 a.a., with molecular weight of ~33.0 kDa.

HY-P7617

	ATG3 Protein, Human rHuATG3; Ubiquitin-like-conjugating enzyme ATG3; autophagy-related protein 3; APG3-like; ATG3; APG3; APG3L	Human	E. coli
	ATG3 Protein, Human is a recombinant human Ubiquitin-like-conjugating Enzyme ATG3 expressed in E. coli. ATG3, the E2 ubiquitin-conjugating enzyme for the LC3 lipidation process, is essential for autophagy.

HY-P70909

	MAP1LC3B Protein, Human Microtubule-associated proteins 1A/1B light chain 3B; autophagy-related protein LC3 B; autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light cha	Human	E. coli
	MAP1LC3B is a key ubiquitin-like modifier essential for the formation of autophagosome vacuoles, which maintains cellular homeostasis. In mitophagy, it regulates mitochondrial number, suppresses reactive oxygen species and ensures energy efficiency. MAP1LC3B Protein, Human is the recombinant human-derived MAP1LC3B protein, expressed by E. coli , with tag free. The total length of MAP1LC3B Protein, Human is 125 a.a., with molecular weight of ~16.15 kDa.

HY-P701246

	ATG10 Protein, Human (GST) Ubiquitin-Like-Conjugating Enzyme ATG10; autophagy-Related Protein 10; APG10-Like; ATG10	Human	E. coli
	ATG10 Protein, Human (GST) is a recombinant human Autophagy Related 10 Homolog (ATG10) expressed in E. coli with a GST tag. ATG10 is an E2 ubiquitin-conjugating-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation.

HY-P702922

	ATG16L1 Protein, Human (P. pastoris, His) autophagy-related protein 16-1; APG16-like 1; APG16L	Human	Sf9 insect cells
	ATG16L1 Protein, Human (P. pastoris, His) is the recombinant human-derived ATG16L1, expressed by Sf9 insect cells , with N-6*His labeled tag. The total length of ATG16L1 Protein, Human (P. pastoris, His) is 607 a.a.,

HY-P701358

	ATG9B Protein, Human (HEK293, FLAG) ATG9B; autophagy-related protein 9B; APG9-like 2; Nitric oxide synthase 3-overlapping antisense gene protein; Protein sONE	Human	HEK293
	ATG9B Protein, a phospholipid scramblase crucial for autophagy, dynamically cycles between the preautophagosomal structure (PAS) and the cytoplasmic vesicle pool. It plays a critical role in expanding autophagosomal membranes, facilitating lipid distribution with ATG2 and driving membrane expansion. Additionally, ATG9B participates in necrotic cell death. ATG9B Protein, Human (HEK293, FLAG) is the recombinant human-derived ATG9B protein, expressed by HEK293 , with C-Flag labeled tag. The total length of ATG9B Protein, Human (HEK293, FLAG) is 924 a.a., .

HY-P70916

	MAP1LC3A Protein, Human (His) Microtubule-Associated Proteins 1A/1B Light Chain 3A; autophagy-Related Protein LC3 A; autophagy-Related Ubiquitin-Like Modifier LC3 A; MAP1 Light Chain 3-Like Protein 1; MAP1A/MAP1B Light Chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-Associated Protein 1 Light Cha	Human	E. coli
	MAP1LC3A is a key ubiquitin-like modifier essential for autophagosome vacuole formation, ensuring cellular homeostasis. As part of the GABARAP/GATE-16 subfamily, it plays a crucial role in late autophagosome maturation. MAP1LC3A Protein, Human (His) is the recombinant human-derived MAP1LC3A protein, expressed by E. coli , with C-6*His labeled tag.

HY-P701359

	ATG9B Protein, Human (HEK293, His, MBP, FLAG) ATG9B; autophagy-related protein 9B; APG9-like 2; Nitric oxide synthase 3-overlapping antisense gene protein; Protein sONE	Human	HEK293
	ATG9B Protein, a phospholipid scramblase crucial for autophagy, dynamically cycles between the preautophagosomal structure (PAS) and the cytoplasmic vesicle pool. It plays a critical role in expanding autophagosomal membranes, facilitating lipid distribution with ATG2 and driving membrane expansion. Additionally, ATG9B participates in necrotic cell death. ATG9B Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived ATG9B protein, expressed by HEK293 , with N-MBP, C-Flag, N-8*His labeled tag. The total length of ATG9B Protein, Human (HEK293, His, MBP, FLAG) is 924 a.a., .

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Species
Source
Tag
Accession
Gene ID
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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80545

	APG5L Antibody APG 5L; APG5; APG5 autophagy 5 like; APG5 like; APG5-like; Apoptosis specific protein; ASP; ATG 5; ATG5 autophagy related 5 homolog; autophagy protein 5; hAPG5	WB, ICC/IF, IP	Human, Mouse, Rat
	APG5L Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 32 kDa, targeting to APG5L. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P81905

	ATG13 Antibody (YA1650) autophagy-related protein 13	WB, IP	Human, Mouse, Rat
	ATG13 Antibody (YA1650) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1650), targeting ATG13, with a predicted molecular weight of 57 kDa (observed band size: 72 kDa). ATG13 Antibody (YA1650) can be used for WB, IP experiment in human, mouse, rat background.

HY-P81236

	ATG10 Antibody autophagy related 10; APG10; APG10L; pp12616	WB, IHC-P	Human, Mouse
	ATG10 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 25 kDa, targeting to ATG10. It can be used for WB,IHC assays with tag free, in the background of Human and mouse.

HY-P80555

	ATG10 Antibody (YA603) autophagy related 10; APG10; APG10L; pp12616	WB, IP	Human
	ATG10 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 25 kDa, targeting to ATG10. It can be used for WB,IP assays with tag free, in the background of Human.

HY-P80557

	ATG4A Antibody ATG4A; APG4A; AUTL2; Cysteine protease ATG4A; AUT-like 2 cysteine endopeptidase; Autophagin-2; autophagy-related cysteine endopeptidase 2; autophagy-related protein 4 homolog A; hAPG4A	WB, IHC-P, IP	Human
	ATG4A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 45 kDa, targeting to ATG4A. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human .

HY-P80558

	ATG4C Antibody ATG4C; APG4C; AUTL1; AUTL3; Cysteine protease ATG4C; AUT-like 3 cysteine endopeptidase; Autophagin-3; autophagy-related cysteine endopeptidase 3; autophagy-related protein 4 homolog C	WB, IHC-P	Human
	ATG4C Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to ATG4C. It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P83336

	ATG9A Antibody (YA3081) ATG9A; APG9-like 1; autophagy 9-like 1 protein; autophagy-related protein 9A; MGD3208; MATG9; APG9 autophagy 9-like 1; APG9L1; autophagy related 9A	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	ATG9A Antibody (YA3081) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3081), targeting ATG9A, with a predicted molecular weight of 94 kDa. ATG9A Antibody (YA3081) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P83725

	ATG4C Antibody (YA3456) ATG4C; APG4C; AUTL1; AUTL3; Cysteine protease ATG4C; AUT-like 3 cysteine endopeptidase; Autophagin-3; autophagy-related cysteine endopeptidase 3; autophagy-related protein 4 homolog C	WB, IP	Human, Mouse, Rat
	ATG4C Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 52 kDa, targeting to ATG4C. It can be used for WB,IP assays with tag free, in the background of Human,Rat,Mouse.

HY-P82723

	ATG4B Antibody (YA2468) ATG4B; APG4B; AUTL1; KIAA0943; Cysteine protease ATG4B; AUT-like 1 cysteine endopeptidase; Autophagin-1; autophagy-related cysteine endopeptidase 1; autophagy-related protein 4 homolog B; hAPG4B	WB, FC	Human, Mouse, Rat
	ATG4B Antibody (YA2468) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2468), targeting ATG4B, with a predicted molecular weight of 44 kDa (observed band size: 44 kDa). ATG4B Antibody (YA2468) can be used for WB, FC experiment in human, mouse, rat background.

HY-P82442

	ATG16L1 Antibody (YA2187) ATG16L1; APG16L; autophagy-related protein 16-1; APG16-like 1	WB	Human, Mouse, Rat
	ATG16L1 Antibody (YA2187) is a biotin-conjugated non-conjugated IgG antibody, targeting ATG16L1, with a predicted molecular weight of 68 kDa (observed band size: 68 kDa). ATG16L1 Antibody (YA2187) can be used for WB experiment in human, mouse, rat background.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-B0351

Taurine 5+ Cited Publications 2-Aminoethanesulfonic acid		Cosolvents pH Modifiers
Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate *autophagy* in adipocytes .

HY-144005

C16 PEG2000 Ceramide C16 PEG Ceramide (MW 2000)		Pegylated Lipids
C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide. C16 PEG2000 Ceramide can be used for lipid carrier to delivery. C16 PEG2000 Ceramide induces *autophagy*. C16 PEG2000 Ceramide can be used for cancer research .

HY-148230

TFEB Decoy ODN sodium		Decoy ODNs
TFEB Decoy ODN sodium is a synthetic oligonucleotide with a hairpin ring structure, which were designed to inhibit Transcription factor EB (TFEB). TFEB decoy ODN inhibited fibrosis and autophagy in a UUO mouse model. The TFEB decoy ODNs also showed anti-inflammatory effects.

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