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leukemia

" in MedChemExpress (MCE) Product Catalog:

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148026

    BGB 11417

    Bcl-2 Family Cancer
    Sonrotoclax is a potent, orally active Bcl2 inhibitor. Sonrotoclax has effective cell killing effect against a variety of lymphoma and leukemia cell lines .
    Sonrotoclax
  • HY-123950

    MDM-2/p53 Apoptosis Cancer
    MMRi64 disrupts Mdm2-MdmX interactions. MMRi64 downregulates Mdm2 and MdmX in leukemia cells. MMRi64 induces p53 accumulation, and induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells. MMRi64 can be used for cancer research .
    MMRi64
  • HY-152470

    Epigenetic Reader Domain Cancer
    Eleven-Nineteen-Leukemia Protein IN-2 (compound 23) is an Eleven-Nineteen-Leukemia Protein (ENL) inhibitor with an IC50 value of 10.7 nM. Eleven-Nineteen-Leukemia Protein IN-2 can be used for the research of leukemia .
    Eleven-Nineteen-Leukemia Protein IN-2
  • HY-E70085

    DNA/RNA Synthesis Infection
    Moloney murine leukemia virus RT is a monomeric reverse transcriptase from Moloney murine leukemia virus (MMLV). Moloney murine leukemia virus RT is a replicative polymerase that play an essential role in the life cycle of the retrovirus .
    Moloney murine leukemia virus RT
  • HY-152469

    Epigenetic Reader Domain Cancer
    Eleven-Nineteen-Leukemia Protein IN-1 is an inhibitor of ENL YEATS domain with an IC50 value of 14.5 nM. Eleven-Nineteen-Leukemia Protein IN-1 interacts with ENL protein and enhances the thermal stability of ENL protein in vitro .
    Eleven-Nineteen-Leukemia Protein IN-1
  • HY-152471

    Epigenetic Reader Domain Cancer
    Eleven-Nineteen-Leukemia Protein IN-3 is an orally active inhibitor of ENL YEATS domain with an IC50 value of 15.4 nM. Eleven-Nineteen-Leukemia Protein IN-3 down-regulates MYC expression through ENL in cells and can enhances the thermal stability of ENL protein in vitro .
    Eleven-Nineteen-Leukemia Protein IN-3
  • HY-169093

    PROTACs Epigenetic Reader Domain Apoptosis Cancer
    MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1), respectively. MS41 effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest and increases apoptosis. MS41 reduces the chromatin occupancy of ENL-associated transcription elongation machinery, and suppresses oncogenic gene expression and leukemia progression. Red: ENL ligand (HY-169094). Black: linker (HY-W105744). Blue: VHL ligand (HY-112078) .
    MS41
  • HY-155288

    Others Cancer
    DosatiLink-1 is an Abelson murine leukemia (ABL) enzyme inhibitor .
    DosatiLink-1
  • HY-N10206

    Endogenous Metabolite Cancer
    11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .
    11-epi-Chaetomugilin I
  • HY-156001

    Deubiquitinase Cancer
    DUB-IN-7 (compound 43) is a Deubiquitinating enzymes (DUBs) inhibitor. DUB-IN-7 can be used in the study of diseases mediated by dysregulated JAK2 activity, such as leukemia .
    DUB-IN-7
  • HY-155557

    Apoptosis Cancer
    Anti-inflammatory agent 45 (compound 2v) is an anticancer agent with direct inhibitory effects on the growth of different blood cancers including leukemia, lymphoma and myeloma cell lines. Anti-inflammatory agent 45 induces apoptosis and inhibits NO production in HL60 leukemia cells (IC50=14.7 μM) .
    Anti-inflammatory agent 45
  • HY-145903

    PDGFR FLT3 Cancer
    PDGFRα/FLT3-ITD-IN-2 (Compound 13d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 20 and 1.654 μM, respectively. PDGFRα/FLT3-ITD-IN-2 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia .
    PDGFRα/FLT3-ITD-IN-2
  • HY-145904

    PDGFR FLT3 Cancer
    PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of 0.153 and 0.004 μM, respectively. PDGFRα/FLT3-ITD-IN-3 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia .
    PDGFRα/FLT3-ITD-IN-3
  • HY-136175
    Revumenib
    5+ Cited Publications

    SNDX-5613

    Epigenetic Reader Domain Cancer
    Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) .
    Revumenib
  • HY-10939A

    Others Cancer
    (-)-15-Deoxyspergualin trihydrochloride is a potent antitumor agent. (-)-15-Deoxyspergualin trihydrochloride shows strong inhibition against mouse leukemia L-1210 .
    (-)-15-Deoxyspergualin trihydrochloride
  • HY-10939

    Others Cancer
    (-)-15-Deoxyspergualin is a potent antitumor agent. (-)-15-Deoxyspergualin shows strong inhibition against mouse leukemia L-1210 .
    (-)-15-Deoxyspergualin
  • HY-153582

    PROTACs Bcr-Abl Cancer
    ML 2-23 is a potent PROTAC BCR-ABL degrader. ML 2-23 is selectively degrade BCR-ABL in a proteasome-dependent manner in leukemia cells .
    ML 2-23
  • HY-145902

    PDGFR FLT3 Cancer
    PDGFRα/FLT3-ITD-IN-1 (Compound 12d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia .
    PDGFRα/FLT3-ITD-IN-1
  • HY-124350

    Antifolate Dihydrofolate reductase (DHFR) Cancer
    10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia .
    10-Formylfolic acid
  • HY-13216
    Pyroxamide
    4 Publications Verification

    HDAC Apoptosis Cancer
    Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia .
    Pyroxamide
  • HY-N7761

    Tetrahydro tanshinone I

    Others Cancer
    Trijuganone B (Tetrahydro tanshinone I) can be extracted from from the roots of Salvia miltiorrhiza f. alba. Trijuganone B inhibits the proliferation of leukemia cells .
    Trijuganone B
  • HY-152036

    PROTACs Bcr-Abl Cancer
    SIAIS100 is a potent BCR-ABL PROTAC degrader with an DC50 value of 2.7 nM. SIAIS100 can be used to research chronic myeloid leukemia (CML) .
    SIAIS100
  • HY-P99207

    KB 003

    SARS-CoV Cancer
    Lenzilumab (KB 003) is a human monoclonal antibody targeting CSF2/GM-CSF for COVID-19, chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) studies .
    Lenzilumab
  • HY-162676

    PROTACs Src Cancer
    SJ45566 a potent and orally active PROTAC-based LCK degrader, with a DC50 of 1.21 nM. SJ45566 can be used in the research for T‑Cell Acute Lymphoblastic Leukemia .
    SJ45566
  • HY-148669A

    Menin-MLL inhibitor 24 oxalate

    Epigenetic Reader Domain Cancer
    Menin-MLL inhibitor 24 (compound A) oxalate is a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor, and can be used for the research of cancer .
    Bleximenib oxalate
  • HY-P990786

    FLT3 ADC Antibody Cancer
    Anti-FLT3 Antibody (AGS62P) is an ADC antibody targeting FLT3, and can be used for acute myelogenous leukemia .
    Anti-FLT3 Antibody (AGS62P)
  • HY-145690

    FLT3 Cancer
    HP1328 is a potent inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1328 is a benzoimidazole scaffold-based compound. HP1328 significantly reduces the leukemia burden and prolongs the survival of mice with FLT3/ITD leukemia .
    HP1328
  • HY-N13294

    TMJ-105

    Apoptosis JAK STAT p38 MAPK JNK ERK Cancer
    Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of JNK and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC50 value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy .
    Cernuumolide J
  • HY-125151

    STAT Apoptosis Cancer
    BP-1-108 is a selective inhibitor of STAT5 (Ki=8.3 μM) with anticancer activity. BP-1-108 induces apoptosis of leukemia cells by inhibiting the phosphorylation of STAT5. BP-1-108 can be used in the study of acute myeloid leukemia and prostate cancer .
    BP-1-108
  • HY-162008

    HSP Bcl-2 Family Cancer
    S1g-10 is a Hsp70/Bim inhibitor, and shows antitumor activity in chronic myeloid leukemia cells .
    S1g-10
  • HY-163725

    Dihydrofolate reductase (DHFR) Cancer
    DHFR-IN-18 (compound 19D) is a DHFR inhibitor. DHFR-IN-18 can be used in anti-leukemia research .
    DHFR-IN-18
  • HY-N0128
    Sclareol
    1 Publications Verification

    Apoptosis Cancer
    Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia?(P-388), human epidermal?carcinoma?(KB) cells and human?leukemia?cell lines. Sclareol induces cell apoptosis .
    Sclareol
  • HY-121785

    Others Infection Cancer
    10-Thiofolic acid is a potent antibacterial and antitumor agent. 10-Thiofolic acid inhibits the growth of Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 7469). 10-Thiofolic acid has the potential for the research of leukemia .
    10-Thiofolic acid
  • HY-W787717

    HIV Infection Inflammation/Immunology Cancer
    12-Methoxydodecanoic acid, a heteroatom-containing analog of myristic acid, possesses anti-viral activity against HIV, with an IC50 of 6.8 μM. 12-Methoxydodecanoic acid inhibits moloney murine leukemia virus (MoMLV) .
    12-Methoxydodecanoic acid
  • HY-N8426

    Ellisinin A

    Histamine Receptor Cancer
    4'-O-Methylnyasol is an inhibitor of β-hexosaminidase. 4'-O-Methylnyasol inhibits β-hexosaminidase release from rat basophilic leukemia-2H3 cells with an IC50 of 52.67 μM .
    4'-O-Methylnyasol
  • HY-N8386

    Antibiotic Infection Cancer
    Berkeleylactone F is an antibiotic macrolide compound. Berkeleylactone F showed modest inhibition of CCRF-CEM leukemia cells .
    Berkeleylactone F
  • HY-164515

    Apoptosis Cancer
    ONC213 is an αKGDH inhibitor that suppresses mitochondrial respiration and elevates α-ketoglutarate levels by inhibiting αKGDH activity, leading to apoptosis (Apoptosis) in AML cells. ONC213 can be used in acute myeloid leukemia research .
    ONC213
  • HY-129407A

    Ser/Thr Protease Apoptosis Cancer
    AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces apoptosis. AAF-CMK can be used in leukemia research .
    AAF-CMK
  • HY-148284

    Others Cancer
    Berbamine acetate (Compound 3a) is the derivative of Berbamine (HY-N0714). Berbamine acetate exhibits antitumor activity, inhibits growth of Imatinib (HY-15463)-resistant K562 leukemia cells, with IC50 of 6.6 μM .
    Berbamine acetate
  • HY-119784

    Others Cancer
    Eupenifeldin is pentacyclic bistropolone isolated from cultures of Eupenicillium brefeldianum ATCC 74184. Eupenifeldin is cytotoxic against the HCT-116 cell line. Eupenifeldin has the potential for the research of leukemia .
    Eupenifeldin
  • HY-P99034

    ADC Antibody CD22 Inflammation/Immunology Cancer
    Moxetumomab, a recombinant CD22-targeting immunotoxin, can be used for the research of hairy cell leukemia (HCL) .
    Moxetumomab
  • HY-125321

    Others Cancer
    Lychnostatin 2 exhibits cytotoxicity in cell P-388 with an ED50 of 0.19 µg/ml. Lychnostatin 2 can be used in research abour leukemia .
    Lychnostatin 2
  • HY-W194107

    Others Cancer
    Antitumor agent-152 (Compound 5) is an anticancer agent that can inhibit the uptake of 3H-dC in L1210 leukemia cells with an IC50 value of 1.12 μM .
    Antitumor agent-152
  • HY-164456

    Histone Methyltransferase Cancer
    AMI-408 is a PRMT1 inhibitor. AMI-408 can reduce H4R3me2as level in MLL-GAS7 leukemia cells .
    AMI-408
  • HY-78884

    Amino Acid Derivatives Cancer
    Anticancer agent 9, a glycine derivative, is an anticancer agent. Anticancer agent 9 can inhibit tumor cells viability of myelogenous leukemia and human prostate cancer .
    Anticancer agent 9
  • HY-N0117A

    (Z)-Couroupitine B; (Z)-Indigo red; (Z)-Indigopurpurin

    Apoptosis Cancer
    (Z)-Indirubin is an isomer of Indirubin (HY-N0117). Indirubin is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .
    (Z)-Indirubin
  • HY-111209

    S14161

    PI3K Cancer
    Pichromene (S14161) is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research .
    Pichromene
  • HY-126156

    Desacetoxymatricarin

    Others Cancer
    Leucodin is a sesquiterpene lactone derived from Gynoxys verrucosa. Leucodin has cytotoxic activity on human leukemia cells .
    Leucodin
  • HY-149625

    Bcl-2 Family Cancer
    Bcl-2-IN-15 (Compound 13d)) is a Bcl-2 inhibitor (IC50: 363 nM). Bcl-2-IN-15 inhibits the proliferation ofNCI leukemia cancer cell line .
    Bcl-2-IN-15
  • HY-118726

    Topoisomerase Cancer
    Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II .
    Luotonin F

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