Search Result

Results for "

ROS,

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ROS Kinase (51) Acyltransferase (1) Adenosine Receptor (2) Akt (18) Aldehyde Dehydrogenase (ALDH) (5) Aldose Reductase (1) AMPK (7) Amyloid-β (4) Anaplastic lymphoma kinase (ALK) (24) Androgen Receptor (2) Angiotensin Receptor (3) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (19) AP-1 (2) Apoptosis (243) Arenavirus (1) Atg8/LC3 (3) ATP Synthase (2) Autophagy (74) Bacterial (49) Bcl-2 Family (13) Bcr-Abl (2) BCRP (1) Biochemical Assay Reagents (6) c-Met/HGFR (9) c-Myc (3) Calcium Channel (7) Cannabinoid Receptor (2) Carbonic Anhydrase (2) Carboxylesterase (1) Caspase (15) CDK (5) Chemerin Receptor (2) Cholinesterase (ChE) (11) Complement System (1) COX (14) Cuproptosis (4) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (7) Deubiquitinase (1) Dihydroorotate Dehydrogenase (1) Discoidin Domain Receptor (2) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (7) Drug Metabolite (4) Dynamin (1) DYRK (1) EGFR (8) Endogenous Metabolite (76) Enterovirus (1) ERK (12) Estrogen Receptor/ERR (4) FAK (2) Fatty Acid Synthase (FASN) (1) Ferroptosis (35) FKBP (1) FLT3 (2) Fluorescent Dye (15) Fungal (31) GABA Receptor (2) Glucosidase (2) Glutaminase (3) Glutathione Peroxidase (4) Glutathione S-transferase (1) GnRH Receptor (1) GSK-3 (3) HBV (4) HCV (1) HDAC (6) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (6) Histamine Receptor (4) Histone Methyltransferase (1) HIV (3) HMG-CoA Reductase (HMGCR) (6) HSP (3) IGF-1R (1) iGluR (1) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (8) Interleukin Related (8) Isotope-Labeled Compounds (18) JAK (6) JNK (13) Keap1-Nrf2 (17) Lactate Dehydrogenase (3) Lipoxygenase (5) MAP3K (2) MDM-2/p53 (11) Microtubule/Tubulin (15) Mitochondrial Metabolism (23) Mixed Lineage Kinase (1) MMP (8) Monoamine Oxidase (6) mTOR (5) Na+/Ca2+ Exchanger (2) NADPH Oxidase (7) NAMPT (2) Necroptosis (3) NEDD8-activating Enzyme (1) NF-κB (22) NKCC (1) NO Synthase (8) NOD-like Receptor (NLR) (10) Notch (2) Nuclear Factor of activated T Cells (NFAT) (1) Nucleoside Antimetabolite/Analog (1) Oct3/4 (1) Organoid (1) Oxidative Phosphorylation (6) P-glycoprotein (3) P2Y Receptor (1) p38 MAPK (8) p62 (3) Paraptosis (2) Parasite (17) PARP (4) PD-1/PD-L1 (3) PDGFR (1) PDHK (1) PDK-1 (1) Phosphatase (4) Phosphodiesterase (PDE) (2) PI3K (13) PKA (2) PKC (2) Polo-like Kinase (PLK) (1) Potassium Channel (2) PPAR (6) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (2) PROTACs (2) Proteasome (3) Pyroptosis (6) Pyruvate Kinase (1) Raf (1) RAR/RXR (1) Ras (3) Reactive Oxygen Species (418) RIP kinase (1) ROR (2) SARS-CoV (2) SGLT (1) Sigma Receptor (5) Sirtuin (4) Small Interfering RNA (siRNA) (3) SOD (1) STAT (3) STING (2) Survivin (1) TAM Receptor (1) Tau Protein (2) TGF-beta/Smad (5) TGF-β Receptor (1) TNF Receptor (7) Toll-like Receptor (TLR) (3) Topoisomerase (17) Trk Receptor (6) TrxR (6) Tyrosinase (3) VDAC (1) VEGFR (4) Virus Protease (2) Xanthine Oxidase (4) β-catenin (4) γ-secretase (1)
By Research Areas:	Cancer (394) Cardiovascular Disease (45) Endocrinology (8) Infection (103) Inflammation/Immunology (157) Metabolic Disease (71) Neurological Disease (97)
Click Chemistry:	Azide (1) Alkynes (3)
Oligonucleotides:	Nucleotides and their Analogs (1) Pre-designed siRNA Sets (3) siRNAs (3)

685

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

203

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: ROS Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153591

ROS-IN-1	Reactive Oxygen Species	Infection Neurological Disease Inflammation/Immunology Cancer
ROS-IN-1 is a mitochondrial *ROS* inhibitor. ROS-IN-1 can reduce oxidative stress or inhibit reactive oxygen species (ROS) production .

HY-148228

ROS kinases-IN-1	ROS Kinase	Cancer
ROS kinases-IN-1 (pag 98) is a ROS tyrosine kinase inhibitor with IC₅₀ value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity .

HY-148314

ROS kinases-IN-2	ROS Kinase	Cancer
ROS kinases-IN-2 is a ROS kinase inhibitor with 21.53% inhibition at 10 μM .

HY-161975

ROS1-IN-2	ROS Kinase	Cancer
ROS1-IN-2 (Compound 3) is a *ROS1* inhibitor. ROS1-IN-2 can be used in the study of cancer .

HY-168177

ROS-IN-3	Reactive Oxygen Species	Neurological Disease
ROS-IN-3 (compound x38) is a *ROS* inhibitor. ROS-IN-3 can be used in neuro-related research .

HY-107563

ROS 234	Histamine Receptor	Inflammation/Immunology
ROS 234 is a potent H3 antagonist, with a pK_B of 9.46 for Guinea-pig ileum H₃-receptor, a pK_i of 8.90 for Rat cerebral cortex H₃-receptor, and a ED₅₀ of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diaplays poor central access .

HY-149586

ROS-IN-2	Reactive Oxygen Species	Others
ROS-IN-2 (compound 85) is a seco-lupane triterpenoid derivative. ROS-IN-2 blocks *ROS* production and protects mitochondria from damage by inhibiting excessive production of oxidative stressors. ROS-IN-2 can be used for myocardial ischemia/reperfusion (MI/R) injury research .

HY-150974

ROS1-IN-1	ROS Kinase	Cancer
ROS1-IN-1 (Compound 31) is a potent and selective *ROS1* kinase inhibitor with an IC₅₀ of 0.097 μM .

HY-107563A

ROS 234 dioxalate	Histamine Receptor	Inflammation/Immunology
ROS 234 dioxalate is a potent H3 antagonist, with a pK_B of 9.46 for Guinea-pig ileum H₃-receptor, a pK_i of 8.90 for Rat cerebral cortex H₃-receptor, and a ED₅₀ of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 dioxalate diaplays poor central access .

HY-155661

ROS inducer 2	Reactive Oxygen Species	Infection
ROS inducer 2 (Compound I16) is a ROS inducer. ROS inducer 2 has good activity in vitro, with an EC₅₀ of 3.43 μg/mL. ROS inducer 2 has outstanding bioactivities in vivo against Xanthomonas axonopodis pv. citri. ROS inducer 2, as a bactericidal agent, can be used for the research of intractable plant bacterial diseases .

HY-155662

ROS inducer 3	Reactive Oxygen Species	Infection
ROS inducer 3 (Compound I6) is a ROS inducer. ROS inducer 3 has excellent in vitro bioactivity with an EC₅₀ of 2.86 μg/mL. ROS inducer 3 has significant protective activity for preventing Pseudomonas syringae pv. actinidiae. ROS inducer 2, as a bactericidal agent, can be used for the research of intractable plant bacterial diseases .

HY-169253

ROS inducer 5	Reactive Oxygen Species Apoptosis	Cancer
ROS inducer 5 (compound 6e) can induce intracellular *ROS* accumulation and subsequent nuclear fragmentation. ROS inducer 5 can induce apoptosis in MCF-7 cells, with an IC₅₀ value of 3.85 μM. ROS inducer 5 can be used in anticancer research .

HY-159518

ROS inducer 4	Reactive Oxygen Species Mitochondrial Metabolism Apoptosis	Cancer
ROS inducer 4 (compound TE3) is a mitochondrial inhibitor. ROS inducer 4 causes a series of mitochondria-related physiological changes in tumors, such as mitochondrial fragmentation, explosive generation and accumulation of *ROS, decreased mitochondrial membrane potential, decreased ATP content, and activation of ROS-mediated apoptotic* signaling in mitochondria .

HY-149265

ROS-generating agent 1	Reactive Oxygen Species TrxR Ferroptosis Apoptosis	Cancer
ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities .

HY-155644

ROS inducer 1	Bacterial Reactive Oxygen Species	Infection
ROS inducer 1 (compound I₂₉) is a fungicide, with EC₅₀ against Xanthomonas axonopodis pv. citri (Xac), Xanthomonas oryzae pv. oryzae (Xoo), and Pseudomonas syringae pv. actinidiae (Psa) of 5.73, 6.62 and 9.05 μg/mL. ROS inducer 1 can effectively induce the production of ROS in Xanthomonas cells and inhibit rice bacterial blight. ROS inducer 1 has the potential to study bacterial infection in crops .

HY-126712

ROS tracer precursor	Biochemical Assay Reagents	Neurological Disease
ROS tracer precursor is the precursor of [ ¹⁸F]ROStrace for the synthesis of ROStrace, which can be used for disease diagnosis .

HY-142956

ROS-ERS inducer 1	Reactive Oxygen Species	Cancer
ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin .

HY-RS12135

ROS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ROS1 Human Pre-designed siRNA Set A contains three designed siRNAs for ROS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ROS1 Human Pre-designed siRNA Set A ROS1 Human Pre-designed siRNA Set A

HY-RS12136

Ros1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ros1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ros1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ros1 Mouse Pre-designed siRNA Set A Ros1 Mouse Pre-designed siRNA Set A

HY-RS12137

ROS1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ROS1 Rat Pre-designed siRNA Set A contains three designed siRNAs for ROS1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

ROS1 Rat Pre-designed siRNA Set A ROS1 Rat Pre-designed siRNA Set A

HY-D1740

Dihydrotetramethylrosamine DHTM Ros	Fluorescent Dye	Others
Dihydrotetramethylrosamine (DHTM Ros) is a fluorogenic substrate for peroxidase that oxidizes to fluorescent tetramethylrosamine chloride.

HY-160172

*ALK/ROS1-IN-4*	Anaplastic lymphoma kinase (ALK) ROS Kinase	Cancer
ALK/ROS1-IN-4 (example 13) is a dual inhibitor of ALK and ROS1 kinase .

HY-160172A

*ALK/ROS1-IN-4 hydrate*	Anaplastic lymphoma kinase (ALK) ROS Kinase	Cancer
ALK/ROS1-IN-4 (hydrate) (example 13) is a dual inhibitor of ALK and ROS1 kinase .

HY-157391

*ALK/ROS1-IN-3*	ROS Kinase Anaplastic lymphoma kinase (ALK)	Cancer
ALK/ROS1-IN-3 (compound C01) is a *ROS1* and ALK dual inhibitor with IC₅₀s of 42.3 nM and 49.1 nM for ROS1 ^G2032R and ALK ^G1202R, respectively .

HY-130794

*ALK/ROS1-IN-1*	Anaplastic lymphoma kinase (ALK) ROS Kinase	Cancer
ALK/ROS1-IN-1 (compound 2e) is a potent and selective anti crizotinib-resistant *ALK/ROS1* dual inhibitor, with IC₅₀s of 0.174 μM and 0.530 μM for ALK and ROS1 enzyme, respectively.

HY-159147

SIAIS039	PROTACs ROS Kinase Apoptosis	Cancer
SIAIS039 is an orally active c-ros oncogene 1 (ROS1)-specific PROTAC with DC₅₀s of 154.46 nM, 126.47 nM, 143.69 nM for HCC78 cells, Ba/F3 expressing the CD74-ROS1 fusion and Ba/F3 expressing the SDC4-ROS1 fusion, respectively. SIAIS039 suppresses cell proliferation, induces cell cycle arrest and apoptosis, and inhibits clonogenicity against ROS1-positive cells. SIAIS039 demonstrates anti-tumour effects against ROS1-driven tumor growth vivo. SIAIS039 is composed of the ALK inhibitor Brigatinib (HY-12857), a linker EM-12 (HY-138793), and a VHL ligand E3 ubiquitin ligase 1-Butyne (Red: Brigatinib; Blue: VHL ligand; Black: linker) .

HY-131003

Taletrectinib 1 Publications Verification DS-6051b; AB-106; IBI-344	ROS Kinase	Cancer
Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective *ROS1/NTRK* inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC₅₀s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants .

HY-131003A

Taletrectinib free base DS-6051b free base; AB-106 free base; IBI-344 free base	ROS Kinase	Cancer
Taletrectinib (DS-6051b) free base is a potent, orally active, and next-generation selective *ROS1/NTRK* inhibitor. Taletrectinib free base potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC₅₀s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib free base also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants .

HY-N11934

Piperkadsin A	Reactive Oxygen Species	Inflammation/Immunology Cancer
Piperkadsin A is a potent inhibitor of *ROS. Piperkadsin inhibits PMA-induced ROS* production in human polymorphonuclear neutrophils with an IC₅₀ of 4.3 μM .

HY-W020772

Aminoguanidine hemisulfate 3 Publications Verification	Reactive Oxygen Species	Cancer
Aminoguanidine hemisulfate is an inhibitor of NOS and *ROS. Aminoguanidine hemisulfate abolishes ANE-induced ROS* production in vitro. Aminoguanidine hemisulfate is used for cancer research .

HY-123815

BRD5459	ROS Kinase	Cancer
BRD5459 is a *ROS* chemical probe. BRD5459 can increase ROS, a marker of oxidative stress in cells, without causing cell death .

HY-139369

QD394	Reactive Oxygen Species	Cancer
QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis .

HY-152292

Zidesamtinib NVL-520; NUV-520	ROS Kinase	Cancer
Zidesamtinib (NVL-520) is a potent, selective, orally active and brain-penetrant inhibitor of diverse ROS1 fusions and resistance mutations, with IC₅₀s of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively, and spares TRK inhibition. Zidesamtinib can be used for the research of cancer .

HY-100561S1

Tempol-d17 4-Hydroxy-TEMPO-d₁₇	Autophagy Reactive Oxygen Species	Cancer
Tempol-d₁₇ is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS)[2][3].

HY-100561S

Tempol-d17,15N 4-Hydroxy-TEMPO-d₁₇,¹⁵N	Autophagy Reactive Oxygen Species	Cancer
Tempol-d₁₇, ¹⁵N is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS)[2][3].

HY-118315

L-012	Reactive Oxygen Species	Others
L-012 is a chemiluminescent probe that reacts with various types of *ROS* produced by activated neutrophils in human blood, oral cavity, and rat peritoneum and produces strong chemiluminescence (CHL). L-012 produces CHL primarily by reacting with hydroxyl radicals and hypochlorite. L-012 can be used to study *ROS* generation in complex biological systems and the role of *ROS* in the pathogenesis of various diseases .

HY-148660

SFI003	Apoptosis Reactive Oxygen Species	Cancer
SFI003 is a SRSF3 inhibitor that drives CRC cell apoptosis via the SRSF3/DHCR24/ROS axis and exhibits potent antitumor effects both in vitro and in vivo .

HY-145574

Iruplinalkib WX-0593	Anaplastic lymphoma kinase (ALK) ROS Kinase	Cancer
Iruplinalkib (WX-0593) is a potent, selective, and orally active inhibitor of ALK and *ROS1* tyrosine kinase. Iruplinalkib (WX-0593) shows favorable safety and promising antitumor activity in advanced NSCLC with ALK or ROS1 rearrangement .

HY-N8418

Cearoin	Autophagy Reactive Oxygen Species ERK Apoptosis	Cancer
Cearoin increases autophagy and apoptosis through the production of *ROS* and the activation of ERK .

HY-159004

Se-DOPE	Reactive Oxygen Species	Metabolic Disease Inflammation/Immunology
Se-DOPE is a phospholipid molecule with selenium. Se-DOPE can be used to synthesize the bifunctional Janus liposozyme. Se-DOPE promotes the production of *ROS* with induction of lights, scavenges the *ROS* with the presence of glutathione. Se-DOPE regulates redox and immune homeostasis in infected diabetic wounds .

HY-100768

HTHQ 2 Publications Verification 1-O-hexyl-2,3,5-trimethylhydroquinone; HX-1171; BTT-105	Reactive Oxygen Species	Cancer
HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) is a potent lipophilic phenolic antioxidant. HTHQ has considerable anti-oxidative activity by directly reacting with reactive oxygen species (ROS) and scavenging *ROS* to form more stable free radicals .

HY-W015913S

Sodium 2-oxopropanoate-13C3 Sodium pyruvate-¹³C₃	Reactive Oxygen Species Endogenous Metabolite	Metabolic Disease
Sodium 2-oxopropanoate- ¹³C₃ is the ¹³C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].

HY-W015913S1

Sodium 2-oxopropanoate-d3 Sodium pyruvate-d₃	Endogenous Metabolite Reactive Oxygen Species	Metabolic Disease
Sodium 2-oxopropanoate-d₃ is the deuterium labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].

HY-W015913S3

Sodium 2-oxopropanoate-13C	Endogenous Metabolite Reactive Oxygen Species	Metabolic Disease
Sodium 2-oxopropanoate- ¹³C is the ¹³C labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].

HY-163107

Antimycobacterial agent-7	Bacterial	Infection
Antimycobacterial agent-7 (compound 4) is a 1,2,4-triazole anti-tuberculosis agent (MIC: 2 μg/mL). Antimycobacterial agent-7 inhibits Mtb KatG and causes the accumulation of ROS in Mtb cells. ROS produces oxidative damage, leading to the death of Mtb .

HY-122921

5-Galloylquinic acid 1 Publications Verification	Reactive Oxygen Species	Cancer
5-Galloylquinic acid, an main scavenger of the reactive oxygen species (ROS) in green tea .

HY-N8724

Lamalbid	ROS Kinase	Others
Lamalbid is a natural product that can be found in Lantana montevidensis. Lamalbid inhibits ROS generation .

HY-W015913S4

2-Oxopropanoate-13c2 sodium	Endogenous Metabolite Reactive Oxygen Species	Metabolic Disease
2-Oxopropanoate- ¹³C₅ (sodium) is the ¹³C labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].

HY-159605

Autophagy inducer 5	Autophagy JNK Reactive Oxygen Species	Cancer
Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC₅₀: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the *ROS/JNK* signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects .

HY-100561

Tempol 15+ Cited Publications 4-Hydroxy-TEMPO	Reactive Oxygen Species Autophagy	Cancer
Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8418

Cearoin	Dalbergia odorifera T. Chen Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Autophagy Reactive Oxygen Species ERK Apoptosis
Cearoin increases autophagy and apoptosis through the production of *ROS* and the activation of ERK .

HY-122921

5-Galloylquinic acid 1 Publications Verification	other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Reactive Oxygen Species
5-Galloylquinic acid, an main scavenger of the reactive oxygen species (ROS) in green tea .

HY-N1447

Ganoderic acid A 5 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Endogenous metabolite Disease Research Fields Cancer	Apoptosis Autophagy Endogenous Metabolite
Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

HY-18258

Berberine chloride 40+ Cited Publications Natural Yellow 18 chloride	Alkaloids Structural Classification Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite Parasite
Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-N7798

Pennogenin	Structural Classification Natural Products Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
Pennogenin is a bioactive component which can be isolated from T. govanianum rhizomes. Pennogenin exhibits significant in vitro inhibitory effect on release of ROS .

HY-17577

Berberine chloride hydrate 40+ Cited Publications Natural Yellow 18 chloride hydrate	Alkaloids Structural Classification Classification of Application Fields Source classification Ranunculaceae Coptis chinensis Franch. Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite Parasite
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-N4244

Kakkalide	Structural Classification Monophenols Flavonoids other families Classification of Application Fields Source classification Phenols Plants Inflammation/Immunology Disease Research Fields Isoflavones	Reactive Oxygen Species
Kakkalide is an isoflavone derived from the flowers of Pueraria lobata. Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species (ROS)-associated inflammation .

HY-N11934

Piperkadsin A	Structural Classification Monophenols Source classification Phenols Piperaceae Plants Piper kadsura (Choisy) Ohwi	Reactive Oxygen Species
Piperkadsin A is a potent inhibitor of *ROS. Piperkadsin inhibits PMA-induced ROS* production in human polymorphonuclear neutrophils with an IC₅₀ of 4.3 μM .

HY-N8724

Lamalbid	Structural Classification Verbenaceae Source classification Plants Saccharides Monosaccharides Lantana montevidensis Briq.	ROS Kinase
Lamalbid is a natural product that can be found in Lantana montevidensis. Lamalbid inhibits ROS generation .

HY-126956

Porphyra 334	Structural Classification Classification of Application Fields Animals Sunscreen Ketones, Aldehydes, Acids Source classification Metabolic Disease Amino acids Cosmetic Research Disease Research Fields	Reactive Oxygen Species MMP
Porphyra 334 is an antioxidative and anti-photoaging agent. Porphyra 334 suppresses *ROS* production and the expression of MMPs following UVA irradiation .

HY-N7063

Nerol	Infection Structural Classification Natural Products Microorganisms other families Classification of Application Fields Plants Endogenous metabolite Disease Research Fields	Reactive Oxygen Species Fungal Mitochondrial Metabolism Apoptosis Endogenous Metabolite
Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and *ROS. Antifungal* activity .

HY-N4161

Euparin	Monophenols Source classification Phenols Plants Compositae Guilandina minax (Hance) G. P. Lewis	Reactive Oxygen Species
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects .

HY-N10176

D-Isofloridoside	Cardiovascular Disease other families Classification of Application Fields Source classification Plants Disease Research Fields Saccharides	Reactive Oxygen Species MMP
D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9 .

HY-N3245

Moracin C 1 Publications Verification	Structural Classification Source classification Phenols Polyphenols Plants Moraceae	Reactive Oxygen Species COX
Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells .

HY-119502

Camalexin 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Camelina sativa (L.) Crantz Plants Endogenous metabolite Indole Alkaloids Infection Alkaloids Human Gut Microbiota Metabolites Microorganisms Brassicaceae Disease Research Fields	Reactive Oxygen Species Fungal Bacterial
Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production .

HY-N8253

Spiraeoside Quercetin 4′-O-glucoside	Structural Classification Flavonoids Liliaceae Classification of Application Fields Flavonones Source classification Phenols Polyphenols Allium cepa L. Plants Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities .

HY-W015913

Sodium 2-oxopropanoate 5+ Cited Publications Sodium pyruvate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Reactive Oxygen Species Endogenous Metabolite
Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge *ROS* .

HY-N3096

Penduletin	Structural Classification Flavonoids Flavones Verbenaceae Source classification Enkianthus quinqueflorus Lour. Plants Ericaceae	Apoptosis Reactive Oxygen Species
Penduletin is a flavone, that can be isolated from Brickelia pendula and Vitex negundo. Penduletin shows anticancer activity. Penduletin induces apoptosis in the cancer cells through *ROS* generation .

HY-B0722

Histamine dihydrochloride 5+ Cited Publications	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Reactive Oxygen Species
Histamine dihydrochloride is a reactive oxygen species (ROS) inhibitor. Histamine dihydrochloride can suppress *ROS* production and work together with IL-2 to activate T cells and NK cells, leading to immune activation in the tumor microenvironment, which consequently kills acute myeloid leukemia (AML) cells. Histamine dihydrochloride can cause a reduction in vaginal tetrazo reduction, increased epithelial growth, and heightened keratinization in mouse models of ovariectomy. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

HY-N0332

Ziyuglycoside II 1 Publications Verification	Triterpenes Classification of Application Fields Sanguisorba officinalis Linn. Terpenoids Source classification Rosaceae Plants Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species Apoptosis
Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect .

HY-136901

Fusarochromanone FC-101	Cardiovascular Disease Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Reactive Oxygen Species
Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity . Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS) .

HY-N0052C

Sanguinarine (gluconate) Sanguinarin (gluconate); Sanguinarium (gluconate); Pseudochelerythrine (gluconate)	Structural Classification Alkaloids Source classification Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Papaveraceae	Apoptosis Reactive Oxygen Species
Sanguinarine (Sanguinarin) gluconate, a benzophenanthridine alkaloid, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB .

HY-N1447R

Ganoderic acid A (Standard)	Triterpenes Structural Classification Terpenoids Polyporaceae Source classification Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Endogenous metabolite	Apoptosis Autophagy Endogenous Metabolite
Ganoderic acid A (Standard) is the analytical standard of Ganoderic acid A. This product is intended for research and analytical applications. Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.

HY-23119

Sodium thiocyanate, GR, 99% Thiocyanate sodium	Structural Classification Natural Products Classification of Application Fields Animals Source classification Inflammation/Immunology Disease Research Fields	Interleukin Related Reactive Oxygen Species
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine IL-10 levels. Sodium thiocyanate also significantly reduces of *ROS* formation .

HY-W041080

3,5-Di-tert-butylphenol	Infection Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	Fungal Reactive Oxygen Species
3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities. 3,5-Di-tert-butylphenol induces accumulation of reactive oxygen species (ROS).

HY-N0457

Chicoric acid 1 Publications Verification Cichoric acid; Dicaffeoyltartaric acid	Structural Classification Classification of Application Fields Anti-aging Source classification Other Phenylpropanoids Metabolic Disease Plants other families Phenols Polyphenols Phenylpropanoids Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species Apoptosis
Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects .

HY-N3642

Cristacarpin Erythrabyssin I; Erythrabissin I	Leguminosae Erythrina suberosa Roxb. Source classification Plants	Others
Cristacarpin can be extracted from the stem bark of Erythrina suberosa, promotes endoplasmic reticulum (ER) stress, leading to sublethal reactive oxygen species (ROS) production and ultimately cell death through senescence .

HY-N0578

Apigenin 7-glucoside 3 Publications Verification Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigetrin	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Dendranthema morifolium (Ramat.) Tzvel. Phenols Polyphenols Plants Compositae Disease Research Fields Cancer	Reactive Oxygen Species
Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS) .

HY-N0139

Troxerutin 1 Publications Verification Trihydroxyethylrutin	Flavonols Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Plants Monophenols Flavonoids other families Phenols Inflammation/Immunology Disease Research Fields	NOD-like Receptor (NLR)
Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.

HY-N1980

3'-Hydroxypuerarin	Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones	Reactive Oxygen Species
3'-Hydroxypuerarin is an isoflavone isolated from the roots of Pueraria lobata (Willd.) Ohwi. 3'-Hydroxypuerarin is a antioxidant, which shows marked ONOO(-), NO•, total ROS scavenging activities .

HY-N10093

Chamaejasmine Chamaejasmin	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones	Apoptosis AMPK Autophagy Reactive Oxygen Species
Chamaejasmine is a biflavonoid that can be isolated from the roots of Stellera chamaejasme L. Chamaejasmine has antitumor activity. Chamaejasmine induces cell apoptosis, autophagy and ROS production, and activates the activity of AMPK/mTOR signal pathway .

HY-N0052

Sanguinarine Sanguinarin; Sanguinarium; Pseudochelerythrine	Alkaloids Classification of Application Fields Source classification Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer	Apoptosis Autophagy
Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N0052A

Sanguinarine chloride 10+ Cited Publications Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride	Structural Classification Alkaloids Classification of Application Fields Pyridine Alkaloids Sanguinaria canadensis Plants Disease Research Fields Papaveraceae Cancer	Apoptosis Autophagy Bacterial Parasite
Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N2585

Isodeoxyelephantopin	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Amorpha fruticosaL. Plants Compositae Disease Research Fields Cancer	Reactive Oxygen Species NF-κB Autophagy
Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer .

HY-N0819

Raddeanin A 1 Publications Verification	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Raddeanin A is a natural triterpenoid saponin component of Anemone raddeana, with anti-cancer activities. Raddeanin A exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF-κB signal pathway .

HY-N3260

Methyllucidone	Structural Classification Natural Products Source classification Plants Lauraceae	Reactive Oxygen Species Keap1-Nrf2 PI3K
Methyllucidone is a neuroprotective agent and an antioxidant that can be isolated from Lindera erythrocarpa Makino. Methyllucidone inhibits the ROS production, and activates antioxidant signaling pathways that include Nrf-2 and PI3K .

HY-155163

APG-2449	Classification of Application Fields Disease Research Fields Cancer	Anaplastic lymphoma kinase (ALK) ROS Kinase FAK
APG-2449 is an orally active *ALK/ROS1/FAK* inhibitor. APG-2449 shows antitumor activity in mouse models of non-small cell lung cancer (NSCLC) .

HY-18258R

Berberine chloride (Standard)	Alkaloids Structural Classification Phellodendron amurense Rupr. Source classification Rutaceae Plants Isoquinoline Alkaloids	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite Parasite
Berberine (chloride) (Standard) is the analytical standard of Berberine (chloride). This product is intended for research and analytical applications. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-N3307

(+)-Medioresinol	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Oleaceae Fraxinus mandshurica Rupr. Source classification Phenols Polyphenols Plants Disease Research Fields	Bacterial Fungal Reactive Oxygen Species Apoptosis
(+)-Medioresinol is a furofuran type lignan with antifungal, antibacterial and lesishmanicidal activities. (+)-Medioresinol leads to intracellular *ROS* accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. (+)-Medioresinol can reduce the cardiovascular disease risk .

HY-N1195

Sugiol (+)-Sugiol; 10-Deoxoxanthoperol	Structural Classification Cupressaceae Terpenoids Diterpenoids Calocedrus formosana (Florin) Florin Plants	p38 MAPK ERK JNK Interleukin Related TNF Receptor
Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages .

HY-N12233

Condurango glycoside A	Apocynaceae Structural Classification Marsdenia cundurango Rchb.f. Polysaccharides Source classification Plants Saccharides	Apoptosis MDM-2/p53 Reactive Oxygen Species
Condurango glycoside A is an activator of p53. Condurango glycoside A initiates *ROS* generation and up-regulates p53 expression. Condurango glycoside A induces apoptosis and pre-mature senescence associated with DNA damage in HeLa cells .

HY-131616

Ethyl α-eleostearate	Structural Classification Natural Products other families Padina australis Source classification Plants	Others
Ethyl α-eleostearate is isolated from the ethanolic extract of Pseudo-nitzschia australis (PAEE). The PAEE of Pseudomonas australis has anti-neuroinflammatory effects, inhibiting intracellular ROS as well as pro-inflammatory mediators and cytokines .

HY-N12653

Exserohilone (-)-Exserohilone	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Reactive Oxygen Species
Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced *ROS* generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts .

HY-B2130

Uric acid 5+ Cited Publications	Structural Classification Classification of Application Fields Source classification Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Inflammation/Immunology Disease Research Fields Cancer	Reactive Oxygen Species Endogenous Metabolite
Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-116506

Bigelovin	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Acacia auriculiformis A.Cunn. ex Benth Plants Compositae Disease Research Fields Cancer	RAR/RXR Reactive Oxygen Species Apoptosis Autophagy
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .

HY-N11887

Linocinnamarin	Structural Classification Natural Products Source classification Rosaceae Plants Fragaria × ananassa Duch.	Reactive Oxygen Species
Linocinnamarin is a nature product that could be isolated from Fragaria ananassa Duch. Linocinnamarin has anti-inflammatory activity. Linocinnamarin inhibits antigen-stimulated elevation of intracellular free Ca ²⁺ concentration and reactive oxygen species (ROS) .

HY-113544

Physapubenolide	Structural Classification Source classification Physalis angulata L. Solanaceae Plants Steroids	Others
Physapubenolide is a cytotoxic steroidal compound isolated from Physalis, which has the activity of increasing intracellular ROS levels by downregulating TIGAR, thereby inducing apoptosis and autophagosome formation in human breast cancer cells, ultimately inhibiting tumor growth.

HY-B0722R

Histamine dihydrochloride (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite Reactive Oxygen Species
Histamine (dihydrochloride) (Standard) is the analytical standard of Histamine (dihydrochloride). This product is intended for research and analytical applications. Histamine dihydrochloride is a reactive oxygen species (ROS) inhibitor. Histamine dihydrochloride can suppress ROS production and work together with IL-2 to activate T cells and NK cells, leading to immune activation in the tumor microenvironment, which consequently kills acute myeloid leukemia (AML) cells. Histamine dihydrochloride can cause a reduction in vaginal tetrazo reduction, increased epithelial growth, and heightened keratinization in mouse models of ovariectomy. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

HY-N10106

Dihydromyristicin	Natural Products Classification of Application Fields Source classification Centaurea aspera stenophylla Plants Umbelliferae Disease Research Fields Inflammation/Immunology	Reactive Oxygen Species
Dihydromyristicin, a plant flavonoid, has potent anti-inflammatory properties. Dihydromyristicin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways .

HY-N2693

6,8-Diprenylorobol	Structural Classification Flavonoids Source classification Maclura tricuspidata Carriere Plants Moraceae Isoflavones	Apoptosis Reactive Oxygen Species Caspase Akt ERK JNK p38 MAPK Bcl-2 Family
6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS .

Cat. No.	Product Name	Chemical Structure

HY-100561S

Tempol-d17,15N
Tempol-d₁₇, ¹⁵N is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS)[2][3].

HY-W015913S

Sodium 2-oxopropanoate-13C3
Sodium 2-oxopropanoate- ¹³C₃ is the ¹³C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].

HY-132426S

Thiram-d12
Thiram-d₁₂ is the deuterium labeled Thiram. Thiram, a fungicides, is widely used on seeds and as foliar agent on turf, vegetables and fruit.Thiram acts as a vulcanization accelerator in the rubber industry[1]. Thiram induces antioxidant defense and oxidative stress. Thiram can act as a prooxidant resulting in the formation of reactive oxygen species (ROS)[2].

HY-123533S

Resorufin-d6
Resorufin-d₆ is the deuterium labeled Resorufin. Resorufin (NSC 12097) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte[1].

HY-100561S1

Tempol-d17
Tempol-d₁₇ is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS)[2][3].

HY-W015913S1

Sodium 2-oxopropanoate-d3
Sodium 2-oxopropanoate-d₃ is the deuterium labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].

HY-W015913S3

Sodium 2-oxopropanoate-13C
Sodium 2-oxopropanoate- ¹³C is the ¹³C labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].

HY-W015913S4

2-Oxopropanoate-13c2 sodium
2-Oxopropanoate- ¹³C₅ (sodium) is the ¹³C labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].

HY-18258S

Berberine-d6 chloride
Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties[1].

HY-W654078

Bisphenol AF-13C12
Bisphenol AF- ¹³C₁₂ is an isotopic label of Bisphenol AF. Bisphenol AF is used in polycarbonate plastic and epoxy resin manufacturing. Bisphenol AF can significantly increase intracellular ROS levels .

HY-B0847S

Propiconazole-d7

Propiconazole-d₇ is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS)[1].

HY-50878AS

Crizotinib-d9 hydrochloride

Crizotinib-d₉ hydrochloride is deuterated labeled Crizotinib hydrochloride (HY-50878A). Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition .

HY-B1978S

Iprodione-d5
Iprodione-d₅ is the deuterium labeled Iprodione[1]. Iprodione, a dicarboximide fungicide, has a highly specific action, with a capacity to cause oxidative damage through production of free oxygen radicals (ROS). Iprodione does not appear to be species selective[2].

HY-W770183

Uric acid-13C3
Uric acid- ¹³C₃ is ¹³C-labeled Uric acid (HY-B2130). Uric acid is the end product of purine metabolism in the human body. Uric acid can scavenge reactive oxygen species (ROS), such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation.

HY-N7364S

(E)-β-Farnesene-d6
(E)-β-Farnesene-d₆ is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and *ROS. Antifungal* activity .

HY-N7436S

Methyl propyl disulfide-d3
Methyl propyl disulfide-d₃ is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and *ROS. Antifungal* activity .

HY-B0849S

Azoxystrobin-d4
Azoxystrobin-d₄ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

HY-B2130S1

Uric acid-15N2
Uric acid- ¹⁵N₂ is the ¹⁵N labeled Uric acid . Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-B0849S1

Azoxystrobin-d3
Azoxystrobin-d₃ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis[1].

HY-W001187S

Tempo-d18
Tempo-d₁₈ is the deuterium labeled Tempo[1]. Tempo is a classic nitroxide radical and is a selective scavenger of ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[2][3][4][5].

HY-B2130S

Uric acid-13C,15N3
Uric acid- ¹³C, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Uric acid. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2].

HY-B0831S

Buprofezin-d6

Buprofezin-d₆ is the deuterium labeled Buprofezin. Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase[1][2].

HY-14914S1

Azilsartan-d4
Azilsartan-d₄ is the deuterium labeled Azilsartan[1]. Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research[2][3][4][5][6].

HY-17363S1

Dimethyl fumarate-d2

Dimethyl fumarate-d₂ is the deuterium labeled Dimethyl fumarate[1]. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research[2][3].

HY-119695AS1

Simvastatin acid-d9 ammonium

Simvastatin acid-d₉ ammonium is deuterated labeled Simvastatin acid ammonium (HY-119695A). Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .

HY-W015879S

2-Heptanol-d5
2-Heptanol-d₅ is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing *ROS* (reactive oxygen species) accumulation .

HY-116084S

Trimethylamine N-oxide-d9

1 Publications Verification

Trimethylamine N-oxide-d₉ is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].

HY-117433S

4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d₄ is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].

HY-50878S

Crizotinib-d5

Crizotinib-d₅ is the deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition .

HY-B0215S

Acetylcysteine-d3

Acetylcysteine-d₃ is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].

HY-50936S

Trabectedin-d3

Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .

HY-116084S1

Trimethylamine-N-oxide-13C3

Trimethylamine-N-oxide- ¹³C₃ is the ¹³C-labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].

HY-B0166S

L-Ascorbic acid-13C6

L-Ascorbic acid- ¹³C₆ is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

HY-B0166S1

L-Ascorbic acid-13C

L-Ascorbic acid- ¹³C is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

HY-B0215S1

Acetylcysteine-15N

Acetylcysteine- ¹⁵N (N-Acetylcysteine- ¹⁵N) is the ¹⁵N-labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor[1]. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases[5]. Acetylcysteine induces cell apoptosis[2][3]. Acetylcysteine also has anti-influenza virus activities[7].

HY-12678S

Entrectinib-d4

Entrectinib-d4 (NMS-E628-d4; RXDX-101-d4) is the deuterium labeled Entrectinib (HY-12678). Entrectinib is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC₅₀ values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice .

HY-B0847S1

Propiconazole-d3 nitrate

Propiconazole-d₃ (nitrate) is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).

HY-128463S

N-tert-Butyl-α-phenylnitrone-d14

N-tert-Butyl-α-phenylnitrone-d₁₄ is the deuterium labeled N-tert-Butyl-α-phenylnitrone[1]. N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[2][3][4][5].

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6][7].

HY-N0060BS

(E)-Ferulic acid-d3

(E)-Ferulic acid-d₃ is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

HY-12678S1

Entrectinib-d8

Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC₅₀ values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .

HY-B0166S8

L-Ascorbic acid-13C6-1

L-Ascorbic acid- ¹³C₆-1 (L-Ascorbate-1; Vitamin C- ¹³C₆-1) is a ¹³C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks