Search Result

Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

Tyrosine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (20) Btk (59) DYRK (11) FAK (2) FLT3 (42) Pyk2 (1) Syk (18) 5-HT Receptor (6) ADC Antibody (3) ADC Cytotoxin (1) ADC Linker (5) Adenosine Kinase (1) Adrenergic Receptor (3) Akt (6) Aldose Reductase (1) Amino Acid Derivatives (64) Amyloid-β (1) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (13) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (103) Aurora Kinase (2) Autophagy (91) Bacterial (12) Bcl-2 Family (1) Bcr-Abl (39) BCRP (2) Beta-secretase (1) Biochemical Assay Reagents (9) BMX Kinase (2) c-Fms (10) c-Kit (49) c-Met/HGFR (50) c-Myc (1) Calcium Channel (4) CaMK (3) Casein Kinase (1) Caspase (4) CDK (12) COX (4) Cyclic GMP-AMP Synthase (3) Cytochrome P450 (3) Discoidin Domain Receptor (5) DNA-PK (1) DNA/RNA Synthesis (2) Dopamine Receptor (9) Drug Metabolite (10) Drug-Linker Conjugates for ADC (4) E3 Ligase Ligand-Linker Conjugates (1) EGFR (130) Endogenous Metabolite (43) Enterovirus (2) Ephrin Receptor (6) Epigenetic Reader Domain (1) ERK (11) Ferroptosis (11) FGFR (44) Fluorescent Dye (6) Fungal (11) GABA Receptor (2) GDNF Receptor (1) Glucosidase (5) GLUT (4) Glutathione S-transferase (1) GPR35 (1) GSK-3 (2) Haspin Kinase (2) HCV (2) HIF/HIF Prolyl-Hydroxylase (2) Histone Acetyltransferase (1) Histone Methyltransferase (1) HIV (1) HIV Integrase (1) HIV Protease (2) HPPD (2) IFNAR (2) IGF-1R (11) IKK (2) Imidazoline Receptor (1) Influenza Virus (4) Insulin Receptor (14) Interleukin Related (2) IRAK (3) IRE1 (6) Isotope-Labeled Compounds (45) JAK (23) Kinesin (1) Ligands for Target Protein for PROTAC (5) Lipoxygenase (2) LRRK2 (1) MAP3K (1) MAP4K (2) MAPKAPK2 (MK2) (1) MEK (2) Melanocortin Receptor (1) Microtubule/Tubulin (2) Mitophagy (6) MMP (1) Monoamine Oxidase (3) mTOR (3) nAChR (1) Necroptosis (2) NF-κB (3) Notch (1) Nuclear Hormone Receptor 4A/NR4A (2) Opioid Receptor (2) P2X Receptor (1) p38 MAPK (7) Parasite (13) PARP (1) PDGFR (81) PDHK (1) PERK (2) Phosphatase (112) Phosphodiesterase (PDE) (2) Phospholipase (4) PI3K (3) Pim (3) PIN1 (1) PKA (5) PKC (3) Polo-like Kinase (PLK) (1) Potassium Channel (1) PPAR (1) Prostaglandin Receptor (1) PROTAC Linkers (1) PROTACs (4) PTEN (4) Pyroptosis (1) RAD51 (2) Raf (7) Ras (1) Reactive Oxygen Species (1) RET (29) Reverse Transcriptase (4) ROR (2) ROS Kinase (11) SARS-CoV (8) Ser/Thr Protease (2) SHP2 (15) Sirtuin (3) Somatostatin Receptor (1) Src (42) STAT (8) TAM Receptor (17) TGF-β Receptor (1) Thymidylate Synthase (1) Tie (9) Toll-like Receptor (TLR) (1) Topoisomerase (4) Trk Receptor (19) Tyrosinase (18) VEGFR (101) Wee1 (1) Wnt (1) Xanthine Oxidase (1) β-catenin (1)
By Research Areas:	Cancer (605) Cardiovascular Disease (36) Endocrinology (24) Infection (37) Inflammation/Immunology (90) Metabolic Disease (86) Neurological Disease (82)
Click Chemistry:	Azide (5) Alkynes (10)
Oligonucleotides:	Aptamers (1) Antisense Oligonucleotides (2)

965

Inhibitors & Agonists

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101

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275

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Isotope-Labeled Compounds

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Targets Recommended: Btk Syk DYRK Pyk2 BRK FAK FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0473

L-Tyrosine 3 Publications Verification Tyrosine	Endogenous Metabolite	Neurological Disease
L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-10421

Tyrosine kinase inhibitor 2 Publications Verification	c-Met/HGFR	Cancer
Tyrosine kinase inhibitor is a potent tyrosine kinase inhibitor.

HY-P2825

Tyrosine decarboxylase, Microorganism TDC; TyrDC	Endogenous Metabolite	Metabolic Disease Cancer
Tyrosine decarboxylase, Microorganism (TDC) widely exists in plants, insects and different microorganisms, and is often used in biochemical research. Tyrosine decarboxylase is a pyridoxal 5'-phosphate (PLP)-dependent decarboxylase that catalyzes the removal of carboxyl groups from tyrosine to produce tyramine and carbon dioxide .

HY-156912

Tyrosine kinase-IN-7	EGFR	Cancer
Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC₅₀s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC₅₀s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively .

HY-162489

Tyrosine kinase-IN-8	Bcr-Abl	Others
Tyrosine kinase-IN-8 (compound 4e) is a BCR‐ABL1 tyrosine kinase inhibitor (TKI). Tyrosine kinase-IN-8 shows anti-proliferative activity against K562 cells, a chronic myeloid leukemia (CML) cell line (CC₅₀=0.8 µM). Tyrosine kinase-IN-8 can be used in the study of chronic leukemia .

HY-147612

Tyrosine kinase-IN-4	c-Met/HGFR	Cancer
Tyrosine kinase-IN-4 (EXAMPLE 107) is a protein tyrosine kinase inhibitor .

HY-150100

Tyrosine 3-monooxygenase	Others	Others
Tyrosine 3-monooxygenase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-155812

Tyrosine kinase-IN-6	c-Met/HGFR	Cancer
Tyrosine kinase-IN-6 is a potent and promising RON splice variants inhibitor with anti-cancer and o?antineoplastic effects .

HY-P2547

Tyrosine Kinase Peptide 1	Src	Others
Tyrosine Kinase Peptide 1 is a control substrate peptide for c-Src assay .

HY-153639

Tyrosine-PEG4-aminooxy-MMAF	Drug-Linker Conjugates for ADC	Cancer
Tyrosine-PEG4-aminooxy-MMAF is a Linker-Payload conjugate that can be used to synthesize ARX788 .

HY-P1590

Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)	JAK	Inflammation/Immunology Cancer
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide corresponding to amino acids 475 to 491 of mouse JAK2.

HY-100315

XL 999 Tyrosine kinase-IN-1	VEGFR PDGFR FGFR	Cardiovascular Disease
Kinase Assay: Kinase Inhibition Assays Kinase activities of KDR and PDGFRα are measured as the percent of ATP consumed following the kinase reaction using luciferaseluciferin-coupled chemiluminescence. Kinase reactions are initiated by combining test compound (XL 999), ATP, kinases and substrates in a 20 mL volume using 384-well microtiter plates. For KDR, the final reaction mixture contained 3 mM ATP, 1.6 mM poly(Glu, Tyr) 4:1 and 1.5 nM KDR of residues D807-V1356 with an N-terminal GST tag. For PDGFRα, the final reaction mixture contained 2 mM ATP, 10 mM MBP and 14 nM PDGFRα of residues Q551-L1089 with an N-terminal GST tag. The reaction mixture is incubated at room temperature for 4 h (KDR) or 2 h PDGFRα before a 20 mL aliquot of Kinase Glo is added and luminescence signal is measured using a Victor2 plate reader. Total ATP consumption is limited below 50% .

HY-W011458

*3,5-Dinitro-L-tyrosine* sodium**	Amino Acid Derivatives	Others
3,5-Dinitro-L-tyrosine sodium is a tyrosine derivative. 3,5-Dinitro-L-tyrosine sodium as artificial substrate, has zero activity relative to tyrosine as a substrate for tyrosine aminotransferase .

HY-W104477

3-Fluoro-L-tyrosine	Others	Metabolic Disease
3-Fluoro-L-tyrosine is a tyrosine analogue, inhibits transamination by tyrosine aminotransferase (TAT). And 3-FluoroL-tyrosine has been shown to be biologically incorporated into proteins in place of tyrosine. 3-Fluoro-L-tyrosine pretends to be the substrate of rat liver tyrosine aminotransferase, markedly disturbs the Tyr-TAT association .

HY-33549

α-Methyl-p-tyrosine	Others	Neurological Disease Cancer
α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases .

HY-136595

3,5-Difluoro-L-tyrosine	Phosphatase	Others
3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs) .

HY-W000665

2,6-Dimethyl-L-tyrosine Dmt	Opioid Receptor	Neurological Disease
2,6-Dimethyl-L-tyrosine (Dmt) is a tyrosine derivative that enhances receptor affinity, functional bioactivity and in vivo analgesia of opioid peptides .

HY-107848

DL-O-Tyrosine NSC 72345; Ortho-Tyrosine; o-DL-Tyrosine; o-Tyrosine	Amino Acid Derivatives	Others
DL-O-Tyrosine is a tyrosine derivative .

HY-Y0444

D-Tyrosine	Tyrosinase	Metabolic Disease
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth .

HY-W142000

*L-Tyrosine* Hydrazide**	Amino Acid Derivatives	Others
L-Tyrosine Hydrazide is a tyrosine derivative .

HY-W011325

Z-D-tyrosine	Amino Acid Derivatives	Others
Z-D-tyrosine is a tyrosine derivative .

HY-N0473A

*L-Tyrosine* disodium salt** 3 Publications Verification	Amino Acid Derivatives	Others Cancer
L-Tyrosine (disodium) is a tyrosine derivative .

HY-W009592

Glycyl-L-tyrosine	Others	Others
Glycyl-L-tyrosine is a dipeptide containing glycine and L-tyrosine .

HY-Y0444S

*D-Tyrosine-d2*	Isotope-Labeled Compounds Tyrosinase	Metabolic Disease
D-Tyrosine-d₂ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-Y0444S1

*D-Tyrosine-d4*	Tyrosinase	Metabolic Disease
D-Tyrosine-d₄ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-Y0444S2

*D-Tyrosine-d7*	Isotope-Labeled Compounds Tyrosinase	Metabolic Disease
D-Tyrosine-d₇ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-41257

*Boc-L-Tyrosine* methyl ester**	Amino Acid Derivatives	Others
Boc-L-Tyrosine methyl ester is a tyrosine derivative .

HY-N0473R

*L-Tyrosine* (Standard)**	Endogenous Metabolite	Neurological Disease
L-Tyrosine (Standard) is the analytical standard of L-Tyrosine. This product is intended for research and analytical applications. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-141526

O-Methyl-D-tyrosine	Amino Acid Derivatives	Others
O-Methyl-D-tyrosine is a tyrosine derivative .

HY-Y0123

DL-Tyrosine	Others	Neurological Disease
DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine) .

HY-Y0123S1

*DL-Tyrosine-d7*	Isotope-Labeled Compounds	Neurological Disease
DL-Tyrosine-d₇ is the deuterium labeled DL-Tyrosine. DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine)[1][2].

HY-Y0123S2

*DL-Tyrosine-d2*	Isotope-Labeled Compounds	Neurological Disease
DL-Tyrosine-d₂ is the deuterium labeled DL-Tyrosine. DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine)[1][2].

HY-Y0123S3

*DL-Tyrosine-d3*	Isotope-Labeled Compounds	Neurological Disease
DL-Tyrosine-d₃ is the deuterium labeled DL-Tyrosine. DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine)[1][2].

HY-N0473S8

*L-Tyrosine-d2*	Endogenous Metabolite	Neurological Disease
L-Tyrosine-d₂ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S9

*L-Tyrosine-d7*	Endogenous Metabolite	Neurological Disease
L-Tyrosine-d₇ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S14

*L-Tyrosine-d5*	Endogenous Metabolite	Neurological Disease
L-Tyrosine-d₅ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S15

*L-Tyrosine-d3*	Endogenous Metabolite	Neurological Disease
L-Tyrosine-d₃ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-W282259

PTH-tyrosine	Biochemical Assay Reagents
PTH-tyrosine is a kind of biochemical reagent.

HY-N0473S1

*L-Tyrosine-15N*	Endogenous Metabolite	Neurological Disease
L-Tyrosine- ¹⁵N is the ¹⁵N-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S12

*L-Tyrosine-17O*	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
L-Tyrosine- ¹⁷O is the ¹⁷O-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S4

*L-Tyrosine-13C*	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
L-Tyrosine- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S

*L-Tyrosine-d4*	Endogenous Metabolite Isotope-Labeled Compounds	Neurological Disease
L-Tyrosine-d₄ is a deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex[1].

HY-113214

3,5-Diiodo-L-tyrosine	Amino Acid Derivatives	Others
3,5-Diiodo-L-tyrosine is a tyrosine derivative .

HY-W142003

*3-Nitro-L-tyrosine* ethyl ester hydrochloride**	Amino Acid Derivatives	Others
3-Nitro-L-tyrosine ethyl ester hydrochloride is a tyrosine derivative .

HY-W142009

*L-Tyrosine* β-naphthylamide**	Amino Acid Derivatives	Others
L-Tyrosine β-naphthylamide is a tyrosine derivative .

HY-W001940

DL-m-Tyrosine	Others	Cardiovascular Disease
DL-m-Tyrosine shows effects on Arabidopsis root growth. Carbidopa combination with DL-m-tyrosine shows a potent hypotensive effect .

HY-W001940S

*DL-m-Tyrosine-d3*	Isotope-Labeled Compounds	Cardiovascular Disease
DL-m-Tyrosine-d₃ is the deuterium labeled DL-m-Tyrosine. DL-m-Tyrosine shows effects on Arabidopsis root growth. Carbidopa combination with DL-m-tyrosine shows a potent hypotensive effect[1][2].

HY-W012382R

*N-Acetyl-L-tyrosine* (Standard)**	Endogenous Metabolite	Metabolic Disease
N-Acetyl-L-tyrosine (Standard) is the analytical standard of N-Acetyl-L-tyrosine. This product is intended for research and analytical applications. N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.

HY-75853

3,5-Dibromo-D-tyrosine	Amino Acid Derivatives	Others
3,5-Dibromo-D-tyrosine is a tyrosine derivative .

HY-W001037

3,5-Diiodo-D-tyrosine	Amino Acid Derivatives	Others
3,5-Diiodo-D-tyrosine is a tyrosine derivative .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0473

L-Tyrosine 3 Publications Verification Tyrosine	Structural Classification Microorganisms Neurological Disease Classification of Application Fields Anti-aging Source classification Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-P2825

Tyrosine decarboxylase, Microorganism TDC; TyrDC	Classification of Application Fields Disease Research Fields Cancer	Endogenous Metabolite
Tyrosine decarboxylase, Microorganism (TDC) widely exists in plants, insects and different microorganisms, and is often used in biochemical research. Tyrosine decarboxylase is a pyridoxal 5'-phosphate (PLP)-dependent decarboxylase that catalyzes the removal of carboxyl groups from tyrosine to produce tyramine and carbon dioxide .

HY-107848

DL-O-Tyrosine NSC 72345; Ortho-Tyrosine; o-DL-Tyrosine; o-Tyrosine	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Amino Acid Derivatives
DL-O-Tyrosine is a tyrosine derivative .

HY-Y0444

D-Tyrosine	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Tyrosinase
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth .

HY-N0473A

*L-Tyrosine* disodium salt** 3 Publications Verification	Classification of Application Fields Disease Research Fields Cancer	Amino Acid Derivatives
L-Tyrosine (disodium) is a tyrosine derivative .

HY-W009592

Glycyl-L-tyrosine	Structural Classification Classification of Application Fields Solanum tuberosum Linn. Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Monophenols Microorganisms Ketones, Aldehydes, Acids Other Diseases Phenols Solanaceae Disease Research Fields	Others
Glycyl-L-tyrosine is a dipeptide containing glycine and L-tyrosine .

HY-Y0123

DL-Tyrosine	Structural Classification Monophenols Source classification Phenols Amino acids Endogenous metabolite	Others
DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine) .

HY-W001940

DL-m-Tyrosine	Cardiovascular Disease Monophenols Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields	Others
DL-m-Tyrosine shows effects on Arabidopsis root growth. Carbidopa combination with DL-m-tyrosine shows a potent hypotensive effect .

HY-N0473R

*L-Tyrosine* (Standard)**	Structural Classification Microorganisms Source classification Amino acids Endogenous metabolite	Endogenous Metabolite
L-Tyrosine (Standard) is the analytical standard of L-Tyrosine. This product is intended for research and analytical applications. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-W012382R

*N-Acetyl-L-tyrosine* (Standard)**	Structural Classification Human Gut Microbiota Metabolites Monophenols Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite	Endogenous Metabolite
N-Acetyl-L-tyrosine (Standard) is the analytical standard of N-Acetyl-L-tyrosine. This product is intended for research and analytical applications. N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.

HY-113214R

*3,5-Diiodo-L-tyrosine* (Standard)**	Microorganisms Source classification	Amino Acid Derivatives
3,5-Diiodo-L-tyrosine (Standard) is the analytical standard of 3,5-Diiodo-L-tyrosine. This product is intended for research and analytical applications. 3,5-Diiodo-L-tyrosine is a tyrosine derivative .

HY-W012382

N-Acetyl-L-tyrosine	Human Gut Microbiota Metabolites Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Phenols Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.

HY-113248

3-Nitro-L-tyrosine	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Phenols Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions.

HY-N3550

Catalponol	Other Terpenoids Structural Classification Catalpa ovata G. Don Classification of Application Fields Terpenoids Source classification Bignoniaceae Plants Disease Research Fields Cancer	Others
Catalponol is a naphthoquinone derivative. Catalponol enhances dopamine biosynthesis by inducing tyrosine hydroxylase activity. Catalponol also increases the levels of cAMP and tyrosine hydroxylase phosphorylation in PC12 cells .

HY-W041171

3-Chloro-L-tyrosine 3-ChloroTyrosine	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

HY-W008452

H-Tyr(3-I)-OH	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .

HY-113468A

3-O-Methyldopa 3-Methoxy-L-Tyrosine; 3-O-Methyl-L-DOPA	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Dopamine Receptor Endogenous Metabolite
3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine .

HY-N4143

Cyanidin 3-arabinoside	other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Phosphatase
Cyanidin 3-arabinoside is a selective and reversible *protein tyrosine* phosphatase 1B (PTP1B) inhibitor, with an IC₅₀** of 8.91 μM. Cyanidin 3-arabinoside is potential for the research of type 2 diabetes .

HY-N3702

Dehydroabietinol	Structural Classification Terpenoids Verbenaceae Callicarpa bodinieri Levl. Source classification Diterpenoids Plants	Syk
Dehydroabietinol is an abietane diterpenoid. Dehydroabietinol has kinase inhibition activity for spleen tyrosine kinase (SYK) with an IC₅₀ value of 46.4 μM. Dehydroabietinol can be used for the research of immune-mediated disease .

HY-16135A

CEP-11981 tosylate ESK981 tosylate; BOL 303213X tosylate	Classification of Application Fields Disease Research Fields Cancer	VEGFR FGFR
CEP-11981 (tosylate) (ESK981 (tosylate), BOL 303213X (tosylate)) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects .

HY-N12177

Cryptosporioptide A	Structural Classification Flavonoids Microorganisms Source classification Other Flavonoids	Phosphatase
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

HY-N12613

Sydowimide A	Structural Classification Natural Products Microorganisms Marine natural products Source classification Marine microorganism	Phosphatase
Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC₅₀ values of 1.5, 2.4 and 18.83 μM, respectively .

HY-18963

Lavendustin A RG-14355	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields Cancer	EGFR
Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of *epidermal growth factor receptor (EGFR) tyrosine* kinase, with an IC₅₀** of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis .

HY-N7160

2-Hydroxy-3-methylanthraquinone	Quinones Structural Classification Anthraquinones Source classification Rubiaceae Plants Hedyotis diffusa Willd.	Src Apoptosis
2-Hydroxy-3-methylanthraquinone (compound 1) is a natural compound isolated from a water extract of Hedyotis diffusa WILLD. 2-Hydroxy-3-methylanthraquinone shows inhibitory activity against *protein tyrosine* kinases v-src and pp60src, and induces growth arrest and apoptosis** in the HepG2 cancer cells .

HY-108485

Damnacanthal	Structural Classification Classification of Application Fields Source classification Plants Infection Quinones Monophenols Anthraquinones Morinda citrifolia Linn. Rubiaceae Phenols Inflammation/Immunology Disease Research Fields	Src Apoptosis Fungal
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of *p56 ^lck tyrosine* kinase activity. Natural Damnacanthal inhibits p56 ^lck autophosphorylation and phosphorylation of exogenous substrates with IC₅₀s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against Candida albicans** .

HY-N10378

Rubrofusarin 6-O-β-D-glucopyranoside	Monophenols Classification of Application Fields Neurological Disease Cassia obtusifolia L. Source classification Phenols Metabolic Disease Caesalpiniaceae Plants Disease Research Fields	Phosphatase
Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC₅₀ of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression .

HY-N1743

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)	Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Moraceae Broussonetia kazinoki Sieb. et Zucc. Disease Research Fields	Phosphatase
1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes .

HY-124896

Bonannione A 6-Geranylnaringenin; Mimulone	Paulownia tomentosa (Thunb.) Steud. Scrophulariaceae Plants	Phosphatase Apoptosis Autophagy
Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent *protein tyrosine* phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy** through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity .

HY-W013293

Boc-D-Tyr-OH	Structural Classification Natural Products Classification of Application Fields Leguminosae Source classification Other Diseases Vigna radiata (L.) Wilczek Plants Disease Research Fields	Amino Acid Derivatives
Boc-D-Tyr-OH is a tyrosine derivative .

HY-N0755

Rhoifolin	Structural Classification Rhus succedanea Flavonoids Classification of Application Fields Flavones Plants Disease Research Fields Endocrinology Anacardiaceae Cancer	Insulin Receptor GLUT NF-κB p38 MAPK Autophagy
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

HY-B0863

Glyphosate	Microorganisms Source classification	Apoptosis Autophagy Necroptosis
Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders .

HY-N0755R

Rhoifolin (Standard)	Structural Classification Rhus succedanea Flavonoids Flavones Plants Anacardiaceae	Insulin Receptor GLUT NF-κB p38 MAPK Autophagy
Rhoifolin (Standard) is the analytical standard of Rhoifolin. This product is intended for research and analytical applications. Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

HY-N0198

Nordihydroguaiaretic acid 4 Publications Verification NDGA	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Lignans Plants other families Phenols Polyphenols Phenylpropanoids Disease Research Fields Cancer	Lipoxygenase Autophagy Ferroptosis
Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-W007970

H-Phe-Phe-OH	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
H-Phe-Phe-OH is a peptide made of two phenylalanine molecules; Phenylalanine is an essential amino acid and the precursor for the amino acid tyrosine.

HY-N10649

PTP1B-IN-21	Quinones Structural Classification Anthraquinones Rubiaceae Knoxia valerianoides Thorel ex Pitard Plants	Phosphatase
PTP1B-IN-21 is a selective inhibitor of *protein tyrosine* phosphatase 1B (PTP1B; IC₅₀=1.56 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC₅₀**>100 μM), which is a key target for type 2 diabetes inhibition .

HY-N2506

Ginsenoside Ra1	Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Others
Ginsenoside Ra1 is a component from ginseng, inhibits protein tyrosine kinase (PTK) activation induced by hypoxia/reoxygenation .

HY-N2111

Momordicoside A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Plants Disease Research Fields Momordica charantia Linn.	Phosphatase
Momordicoside A is isolated from Momordica charantia L. Momordicoside A has the inhibitory effect on *protein tyrosine* phosphatase (PTP1B)** .

HY-N10648

PTP1B-IN-20	Quinones Structural Classification Anthraquinones Rubiaceae Knoxia valerianoides Thorel ex Pitard Plants	Phosphatase
PTP1B-IN-20 is a selective inhibitor of *protein tyrosine* phosphatase 1B (PTP1B; IC₅₀=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC₅₀**=78.0 μM), which is a key target for type 2 diabetes inhibition .

HY-N5118

Chimonanthine (-)-Chimonanthine	Alkaloids Classification of Application Fields Source classification Chimonanthus nitens Oliv. Plants Disease Research Fields Alkaloid Dimers Cancer Calycanthaceae	Tyrosinase
Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis .

HY-111431

p-Cresyl sulfate 4 Publications Verification p-Tolyl sulfate	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
p-Cresyl Sulfate, a major uremic toxin derived from the metabolites of tyrosine and phenylalanine through liver, existed in the blood of patients with chronic kidney disease (CKD).

HY-N3267

Methyl pseudolarate B	Structural Classification Pinaceae Terpenoids Source classification Diterpenoids Pseudolarix amabilis (J. Nelson) Rehder Plants	Phosphatase
Methyl pseudolarate B, a natural diterpenoid, is a *protein tyrosine* phosphatase 1B (PTP1B) (Phosphatase) inhibitor with an IC₅₀** value of 10.9 μM .

HY-162397

Neopetromin	Structural Classification Monophenols Microorganisms Source classification Phenols	Others
Neopetromin is a tripeptide with a rare heteroaromatic C-N cross-link between side chains of tryptophan and tyrosine. Neopetromin causes vacuole fragmentation in an actin-independent manner .

HY-N4185

Licoflavone A 1 Publications Verification	Flavonoids Neurological Disease Classification of Application Fields Flavones Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch.	Phosphatase
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC₅₀ of 54.5 μM .

HY-W013293R

Boc-D-Tyr-OH (Standard)	Structural Classification Natural Products Leguminosae Source classification Vigna radiata (L.) Wilczek Plants	Amino Acid Derivatives
Boc-D-Tyr-OH (Standard) is the analytical standard of Boc-D-Tyr-OH. This product is intended for research and analytical applications. Boc-D-Tyr-OH is a tyrosine derivative .

HY-N12736

Dehydrodanshenol A	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Source classification Diterpenoids Plants	Phosphatase
Dehydrodanshenol A is a non-competitive inhibitor of Protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ value of 8.5 μM. Dehydrodanshenol A can be used in diabetes-related research .

HY-N0198R

Nordihydroguaiaretic acid (Standard)	Structural Classification other families Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants	Lipoxygenase Autophagy Ferroptosis
Nordihydroguaiaretic acid (Standard) is the analytical standard of Nordihydroguaiaretic acid. This product is intended for research and analytical applications. Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-N6650

Isotanshinone IIA	Quinones Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Metabolic Disease Plants Naphthalene Quinones Disease Research Fields	Phosphatase
Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC₅₀ 0f 11.4 μM.

HY-N1750

3-(2,4-Dihydroxyphenyl)propanoic acid	Structural Classification Natural Products Classification of Application Fields Source classification Plants Moraceae Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Ficus carica L. Other Diseases Phenols Polyphenols Disease Research Fields	Tyrosinase Endogenous Metabolite
3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive tyrosinase inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC₅₀ and a K_i of 3.02 μM and 11.5 μM, respectively .

HY-131669

Dasatinib metabolite M6 Dasatinib carboxylic acid	Classification of Application Fields Disease Research Fields Cancer	Drug Metabolite
Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib (HY-10181). Dasatinib is a potent and orally active dual Bcr-Abl and Src family tyrosine kinase inhibitor .

HY-14596

Genistein Maximum Cited Publications 42 Publications Verification NPI 031L	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Leguminosae Glycine max (L.) merr Sunscreen Phenols Polyphenols Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Cancer	EGFR Autophagy Apoptosis Endogenous Metabolite
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

Cat. No.	Product Name	Chemical Structure

HY-Y0444S1

*D-Tyrosine-d4*
D-Tyrosine-d₄ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-N0473S8

*L-Tyrosine-d2*
L-Tyrosine-d₂ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S9

*L-Tyrosine-d7*
L-Tyrosine-d₇ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S14

*L-Tyrosine-d5*
L-Tyrosine-d₅ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S15

*L-Tyrosine-d3*
L-Tyrosine-d₃ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-Y0444S

*D-Tyrosine-d2*
D-Tyrosine-d₂ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-Y0444S2

*D-Tyrosine-d7*
D-Tyrosine-d₇ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-Y0123S1

*DL-Tyrosine-d7*
DL-Tyrosine-d₇ is the deuterium labeled DL-Tyrosine. DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine)[1][2].

HY-Y0123S2

*DL-Tyrosine-d2*
DL-Tyrosine-d₂ is the deuterium labeled DL-Tyrosine. DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine)[1][2].

HY-Y0123S3

*DL-Tyrosine-d3*
DL-Tyrosine-d₃ is the deuterium labeled DL-Tyrosine. DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine)[1][2].

HY-N0473S1

*L-Tyrosine-15N*
L-Tyrosine- ¹⁵N is the ¹⁵N-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S12

*L-Tyrosine-17O*
L-Tyrosine- ¹⁷O is the ¹⁷O-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S4

*L-Tyrosine-13C*
L-Tyrosine- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S

*L-Tyrosine-d4*
L-Tyrosine-d₄ is a deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex[1].

HY-W001940S

*DL-m-Tyrosine-d3*
DL-m-Tyrosine-d₃ is the deuterium labeled DL-m-Tyrosine. DL-m-Tyrosine shows effects on Arabidopsis root growth. Carbidopa combination with DL-m-tyrosine shows a potent hypotensive effect[1][2].

HY-N0473S10

*L-Tyrosine-d2-1*
L-Tyrosine-d₂-1 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S13

*L-Tyrosine-d2-2*
L-Tyrosine-d₂-2 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S2

*L-Tyrosine-13C6*
L-Tyrosine- ¹³C₆ is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S3

*L-Tyrosine-13C9*
L-Tyrosine- ¹³C₉ is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-W012382S

*N-Acetyl-L-tyrosine-d3*
N-Acetyl-L-tyrosine-d₃ is the deuterium labeled N-Acetyl-L-tyrosine. N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.

HY-N0473S5

*L-Tyrosine-4-13C*
L-Tyrosine-4- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S7

*L-Tyrosine-1-13C*
L-Tyrosine-1- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S11

*L-Tyrosine-15N,d7*
L-Tyrosine- ¹⁵N,d₇ is the deuterium and ¹⁵N-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-113248S

*3-Nitro-L-tyrosine-d3*
3-Nitro-L-tyrosine-d₃ is the deuterium labeled 3-Nitro-L-tyrosine. 3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions[1][2].

HY-N0473S16

*L-Tyrosine-13C,15N*
L-Tyrosine- ¹³C, ¹⁵N is the ¹³C and ¹⁵N labeled L-Tyrosine[1]. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex[2].

HY-Y0123S

*DL-Tyrosine-13C9,15N*
DL-Tyrosine- ¹³C₉, ¹⁵N is the ¹³C- and ¹⁵N-labeled DL-Tyrosine. DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine)[1].

HY-N0473S6

*L-Tyrosine-3,5-13C2*
L-Tyrosine-3,5- ¹³C₂ is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-113248S1

*3-Nitro-L-tyrosine-13C6*
3-Nitro-L-tyrosine- ¹³C₆ is the ¹³C labeled 3-Nitro-L-tyrosine[1]. 3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions[2].

HY-W041171S

*3-Chloro-L-tyrosine-13C6*
3-Chloro-L-tyrosine- ¹³C₆ is the ¹³C labeled 3-Chloro-L-tyrosine[1]. 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima[2].

HY-W018386S1

*3-Bromo-L-tyrosine-13C9*
3-Bromo-L-tyrosine- ¹³C₉ (3-Bromo-Tyr- ¹³C₉) is ¹³C-labeled 3-?Bromo-?L-?tyrosine (HY-W018386) .

HY-101474S

Zanubrutinib-d5
Zanubrutinib-d₅ is deuterium labeled Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (Btk) inhibitor[1].

HY-152852S

Mefatinib-d6 free base
Mefatinib-d6 free base (Mifanertinib-d6) is the deuterium labeled Mefatinib. Mefatinib is a potent tyrosine kinase inhibitor with antineoplastic activity .

HY-15463S1

Imatinib-d4
Imatinib-d₄ is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].

HY-W018386S

*3-Bromo-L-tyrosine-13C6*
3-Bromo-L-tyrosine- ¹³C₆ (3-Bromo-Tyr- ¹³C₆) is a ¹³C-labeled H-Lys-OH.2HCl[1].

HY-50896S

Erlotinib-d6
Erlotinib-d₆ (CP-358774 D6) is a deuterium labeled Erlotinib (CP-358774). Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR[1]. Erlotinib-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-113468AS1

3-O-Methyldopa-d3 hydrate
3-O-Methyldopa-d₃ (hydrate) is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine[1].

HY-B1866S

Linuron-d6
Linuron-d₆ is the deuterium labeled 3-Bromo-L-tyrosine[1].

HY-33549S

DL-Metirosine-13C,d3 hydrochloride
DL-Metirosine- ¹³C,d₃ (hydrochloride) is deuterium labeled α-Methyl-p-tyrosine.

HY-10181S

Dasatinib-d8
Dasatinib-d₈ is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.

HY-10331S

Regorafenib-d3
Regorafenib-d₃ is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor tyrosine kinase inhibitor[1].

HY-15656S

Ceritinib-d7
Ceritinib-d₇ is a deuterium labeled Ceritinib. Ceritinib is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor[1].

HY-10159S

Nilotinib-d6
Nilotinib-d₆ is a deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity[1].

HY-132549S

Nilotinib-d3
Nilotinib-d₃ is the deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity[1][2].

HY-101474BS

(R)-Zanubrutinib-d5
(R)-Zanubrutinib-d₅ is deuterium labeled (R)-Zanubrutinib. (R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor.

HY-50878S

Crizotinib-d5

Crizotinib-d₅ is the deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition .

HY-10260S1

Vandetanib-d4
Vandetanib-d₄ is the deuterium labeled Vandetanib. Vandetanib (ZD6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM)[1][2].

HY-10260S

Vandetanib-d6
Vandetanib-d₆ is the deuterium labeled Vandetanib. Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM)[1].

HY-10260S2

Vandetanib-13C6
Vandetanib-13C6 is a deuterated labeled Vandetanib . Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC₅₀=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC₅₀=110 nM) and EGFR/HER1 (IC₅₀=500 nM) .

HY-50896S1

Erlotinib-13C6
Erlotinib- ¹³C₆ is a ¹³C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].

HY-50895S

Gefitinib-d8
Gefitinib-d₈ is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2].

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