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E3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E3 Ligase Ligand-Linker Conjugates (524) Ligands for E3 Ligase (144) 17β-HSD (1) 5-HT Receptor (2) Acetyl-CoA Carboxylase (2) ADC Cytotoxin (1) ADC Linker (13) Adrenergic Receptor (1) Akt (3) Aldose Reductase (1) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (5) APC (1) Apoptosis (175) Aryl Hydrocarbon Receptor (1) Aurora Kinase (2) AUTACs (1) Autophagy (179) Bacterial (2) Bcl-2 Family (8) BCL6 (2) Bcr-Abl (2) Biochemical Assay Reagents (4) Btk (6) c-Met/HGFR (1) c-Myc (1) CDK (5) Cytochrome P450 (2) Dengue virus (2) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (2) DYRK (1) E1/E2/E3 Enzyme (31) EGFR (5) Endogenous Metabolite (3) Ephrin Receptor (1) Epigenetic Reader Domain (42) ERK (1) Estrogen Receptor/ERR (7) FAK (3) FGFR (2) FKBP (7) FLT3 (1) GABA Receptor (1) GLP Receptor (1) GSK-3 (2) HDAC (8) HIF/HIF Prolyl-Hydroxylase (2) Histone Acetyltransferase (2) Histone Demethylase (1) Histone Methyltransferase (6) Indoleamine 2,3-Dioxygenase (IDO) (1) Integrin (1) IRAK (1) Isotope-Labeled Compounds (9) Keap1-Nrf2 (2) Ligands for Target Protein for PROTAC (13) MAP4K (1) MDM-2/p53 (7) MEK (1) MicroRNA (36) Mixed Lineage Kinase (2) Molecular Glues (32) Mps1 (2) MyD88 (1) NF-κB (4) Nuclear Hormone Receptor 4A/NR4A (1) PARP (4) PD-1/PD-L1 (2) PERK (1) Phosphatase (1) PI3K (1) PIN1 (1) PPAR (1) Progesterone Receptor (1) Prostaglandin Receptor (1) PROTAC Linkers (72) PROTAC-Linker Conjugates for PAC (1) PROTACs (168) Ras (9) Reactive Oxygen Species (1) RIP kinase (1) ROS Kinase (1) SARS-CoV (3) Sirtuin (2) Small Interfering RNA (siRNA) (4) SNIPERs (1) STAT (6) STING (3) Target Protein Ligand-Linker Conjugates (10) Tau Protein (2) VAP-1 (1) Virus Protease (2) YAP (2) α-synuclein (1) β-catenin (5)
By Research Areas:	Cancer (983) Cardiovascular Disease (4) Endocrinology (3) Infection (15) Inflammation/Immunology (46) Metabolic Disease (6) Neurological Disease (11)
Click Chemistry:	ADC Synthesis (6) TCO (18) DBCO (2) PROTAC Synthesis (31) Azide (44) Tetrazine (1) Alkynes (34)
Oligonucleotides:	miRNA mimics (9) miRNA agomirs (9) miRNA antagomirs (9) MicroRNAs (36) Pre-designed siRNA Sets (4) miRNA inhibitors (9) Antisense Oligonucleotides (2) siRNAs (4)

1082

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

E3 ligase Ligand PG	Ligands for E3 Ligase	Cancer
E3 ligase Ligand PG is a E3 ligase ligand that can be used in the recruitment of CRBN protein. E3 ligase Ligand PG exhibits potent binding activity with CRBN (IC₅₀ of 2.191 μM). E3 ligase Ligand PG can be connected to the BMS-202 (HY-19745) by a linker to form PROTAC, PROTAC PD-L1 degrader-1 (HY-163757) .

E3 Ligase Ligand-linker Conjugate 123	E3 Ligase Ligand-Linker Conjugates	Others
E3 Ligase Ligand-linker Conjugate 123 is the E3 ligand-linker part of PROTAC SMARCA2/4-degrader-35 (HY-168225). E3 Ligase Ligand-linker Conjugate 123 can be utilized in the synthesis of PROTACs .

E3 Ligase Ligand-linker Conjugate 128	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 128 (Intermediate 11) is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 128 can be used to synthesize PROTAC BRM/BRG1 degrader-4 (HY-168255) .

E3 ubiquitin ligase binder-1	Ligands for E3 Ligase	Cancer
E3 ubiquitin ligase binder-1 (compound 11) is a potent E3 ubiquitin ligase binder. E3 ubiquitin ligase binder-1 is a ligand for E3 Ligase .

E3 ligase Ligand 30	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 30 is a ligand for E3 ligase.

E3 ligase Ligand 29	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 29 is a ligand for E3 ligase.

E3 ligase Ligand 33	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 33 (56-9B) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 33 can be used in anti-cancer research .

E3 ligase Ligand 7	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 7 (Compound 6) is a ligand for E3 ligase. E3 ligase Ligand 7 can be utilized for the synthesis of PROTAC BET Degrader-12 (HY-158764) .

E3 ligase Ligand 31	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 31 is a ligand for E3 ubiquitinase. E3 ligase Ligand 31 can be used to synthesize PTOTAC HSD17B13 degrader 1 (HY-159651) .

E3 ligase Ligand 10	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

E3 ligase Ligand 18	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

E3 ligase Ligand 14	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

E3 ligase Ligand 8 3 Publications Verification	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

E3 ligase Ligand 13	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 13 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 13 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

E3 ligase Ligand 9	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .

E3 Ligase Ligand-Linker Conjugate Kit	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-Linker Conjugate Kit is a series of synthesized compounds that incorporate an E3 ligase ligand and a linker used in PROTAC technology.

E3 ligase Ligand 24	Others	Cancer
E3 ligase Ligand 24 (Compound 24) is a Potent Ligand for the E3 Ligase DCAF15 (IC₅₀= 0.053 μM). Due to E3 ligase Ligand 24’s selectivity and potent binding characteristics, it is pivotal in the study of targeted protein degradation .

E3 ligase Ligand 35	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 35 serves as the E3 ligase ligand for PROTAC SMARCA2 degrader-27 (HY-168229) .

E3 ligase Ligand 25	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 25 (part of Compd 1) is a ligand for E3 ligase, used for the synthesis of PROTAC SOS1 degrader (HY-161634) .

E3 ligase Ligand 26	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 26 (part of Compd 10) is a ligand for E3 ligase, used for the synthesis of PROTAC SOS1 degrader (HY-161636) .

E3 Ligase Ligand-linker Conjugate 111	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 111 is an E3 ligase ligand-linker conjugate.

E3 Ligase Ligand-linker Conjugate 113	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 113 is an E3 ligase ligand-linker conjugate.

E3 ligase Ligand 32	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743) .

E3 Ligase Ligand-linker Conjugate 115	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 115 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 115 can be used to synthesize PROTAC SMARCA2/4-degrader-27 (HY-162834) .

E3 Ligase Ligand-linker Conjugate 116	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 116 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 116 can be used to synthesize PROTAC SMARCA2/4-degrader-28 (HY-162835) .

E3 Ligase Ligand-linker Conjugate 119	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 119 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 119 can be used to synthesize PROTAC SMARCA2/4-degrader-31 (HY-162744) .

E3 Ligase Ligand-linker Conjugate 117	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 117 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 117 can be used to synthesize PROTAC SMARCA2/4-degrader-29 (HY-162743) .

E3 Ligase Ligand-linker Conjugate 118	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 118 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 118 can be used to synthesize PROTAC SMARCA2/4-degrader-30 (HY-162748) .

E3 ligase Ligand 27	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 27 (part of 15) is a ligand for E3 ligase, used for the synthesis of PROTAC BcI-2/BcI-xI Degrader-1 (HY-158551)

E3 Ligase Ligand-linker Conjugate 112	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 112 is a kind of E3 ubiquitinase ligand + linker conjugates. E3 Ligase Ligand-linker Conjugate 112 can be used to synthesize SMARCA2 degrader-10 (HY-162741) .

E3 Ligase Ligand-linker Conjugate 124	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 124 is an E3 ubiquitinase ligand + linker conjugate. E3 Ligase Ligand-linker Conjugate 124 can be used to synthesize PROTAC SMARCA2 degrader-27 (HY-168229) .

E3 Ligase Ligand-linker Conjugate 114	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 114 is an E3 ubiquitinase ligand + linker conjugate. E3 Ligase Ligand-linker Conjugate 114 can be used to synthesize PTOTAC HSD17B13 degrader 1 (HY-159651) .

E3 ligase Ligand-Linker Conjugate 31	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 31 is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

E3 Ligase Ligand-linker Conjugate 15	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 15 is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

E3 Ligase Ligand-linker Conjugate 48	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 48 is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

E3 ligase Ligand-Linker Conjugate 29	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 29 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 29 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

E3 ligase Ligand-Linker Conjugate 37	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 37 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 37 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

E3 ligase Ligand-Linker Conjugate 38	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 38 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 38 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

E3 ligase Ligand-Linker Conjugate 65	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 65 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 65 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

E3 ligase Ligand-Linker Conjugate 66	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 66 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 66 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 92	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 92 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 92 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 93	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 93 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 93 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 94	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 94 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 94 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 99	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 99 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 99 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 100	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 100 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 100 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

E3 Ligase Ligand-linker Conjugate 104	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 104 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 104 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

Cat. No.	Product Name

HY-L128

E3 Ligase Ligand Library

55 compounds

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 55 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

HY-L050

Ubiquitination Compound Library

271 compounds

Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc.

MCE offers a unique collection of 271 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

HY-L129

Target Protein Ligand Library

43 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 43 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

HY-L045

Oxygen Sensing Compound Library

2,742 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 2,742 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

HY-L137

Molecular Glue Compound Library

41 compounds

Targeted protein degradation(TPD) is a novel and promising approach to new drug discovery and development. It shows great potential for treating diseases with “undruggable” pathogenic protein targets and for overcoming drug resistance. Molecular glues and PROTACs are both targeted protein degraders that have attracted the most attention.

Molecular glues are small molecular degraders that mainly induce novel interaction between an E3 ligase and a target protein to form a ternary complex, leading to protein ubiquitination and subsequent proteasome degradation. Compared with PROTACs, molecular glues generally possess more favorable drug-like properties, such as lower MW, higher cell permeability, and better oral absorption. Molecular glues are emerging as a promising new therapeutic strategy.

MCE supplies a unique collection of 41 molecular glues which target various proteins. MCE Molecular Glue Compound Library is a useful tool to conduct scientific research and disease mechanism study.

Cat. No.	Product Name	Type

HY-D2336

PROTAC Aster-A degrader-1	Fluorescent Dyes/Probes
PROTAC Aster-A degrader-1 (compound NGF3) is a degrader of the sterol transport protein Aster-A. PROTAC Aster-A degrader-1 can be used as a fluorescence probe. (Red: Aster-A inhibitor, black: linker, Blue: E3 ligase ligand) .

Cat. No.	Product Name	Type

HY-44087

*Ethyl (E)-3-(1-pyrrolidinyl)crotonate*	Biochemical Assay Reagents
Ethyl (E)-3-(1-pyrrolidinyl)crotonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-W012845A

*(E)-3-(2-Furyl)acrolein*	Biochemical Assay Reagents
(E)-3-(2-Furyl)acrolein, derived from 2-acid-acid-rich acid reaction, is used in food, cosmetics and other fields, medicine and agriculture. In the food industry, (E)-3-(2-Furyl)acrolein, as a natural seasoning food additive, has an important seasoning effect.

HY-W016298

trans-3,4-Difluorocinnamic acid (E)-3-(3,4-Difluorophenyl)acrylic acid	Biochemical Assay Reagents
trans-3,4-Difluorocinnamic acid ((E)-3-(3,4-Difluorophenyl)acrylic acid) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-W088501

*(E)-3-Pentenoic acid*	Biochemical Assay Reagents
(E)-Pent-3-enoic acidIt is an unsaturated carboxylic acid. (E)-Pent-3-enoic acidAs a starting material for various chemical reactions including esterification, oxidation and reduction. (E)-Pent-3-enoic acidIt has potential use as a flavoring agent in the food industry.

HY-W127401

Triethylene glycol monooctyl ether n-Octyltrioxyethylene	Biochemical Assay Reagents
Triethylene glycol monooctyl ether is a surfactant, C8E3 solubilizes membrane proteins.

Cat. No.	Product Name	Target	Research Area

HY-169232

PCC16 chloride	PROTACs	Cancer
PCC16 chloride is a CRBN-based cp-PCC with an IC₅₀ value of 102 nM for the degradation of *DHHC3*. PCC16 chloride has antitumor activity. (Target protein ligand: HY-169235, linker: HY-169236, E3 ligase ligand: HY-10984) .

HY-P10412

A11 ANXA1-derived 11 amino acid–long peptide	Ephrin Receptor	Cancer
A11 (ANXA1-derived 11 amino acid–long peptide) is an ANXA1-EphA2 interaction blocker peptide. A11 decreases ANXA1 bound to EphA2 and increased Cbl (an E3 ubiquitin ligase of EphA2) bound to EphA2. A11 efficiently decreases EphA2 level, and substantially increases EphA2 ubiquitination. A11 increases EphA2 internalization and colocalization of EphA2 and Cbl in the NPC cells. A11 inhibits nasopharyngeal carcinoma (NPC) cell proliferation, migration and invasion. A11 inhibits angiogenesis .

Cat. No.	Product Name	Target	Research Area

HY-P9934

Abciximab C7E3	Integrin	Cardiovascular Disease
Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors .

Species:	Human (85) Mouse (4) Bovine (1)
Tag:	His (45) SUMO (4) Tag Free (33) Strep (7) Avi (2) Myc (2) GST (11) Fc (2) Flag (1)
Source:	HEK293 (5) E. coli Cell-free (2) Sf9 insect cells (17) P. pastoris (2) E. coli (64)

Cat. No.	Compare	Product Name	Species	Source

HY-P701526

	HACE1 Protein, Human (His) HACE1; E3 ubiquitin-protein ligase HACE1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1	Human	E. coli
	The HACE1 protein is an E3 ubiquitin protein ligase that regulates Golgi membrane fusion and small GTPases. HACE1 Protein, Human (His) is the recombinant human-derived HACE1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HACE1 Protein, Human (His) is 908 a.a., .

HY-P701512

	SMURF2 Protein, Human (His) SMURF2; E3 ubiquitin-protein ligase SMURF2; hSMURF2; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2	Human	E. coli
	SMURF2 protein is an E3 ubiquitin protein ligase that interacts with SMAD7 to induce ubiquitin-dependent degradation of TGF-β receptors and downregulate TGF-β signaling. This interaction triggers autocatalytic degradation of SMURF2 and is antagonized by AIMP1. SMURF2 Protein, Human (His) is the recombinant human-derived SMURF2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SMURF2 Protein, Human (His) is 747 a.a., .

HY-P701487

	UB2E3 Protein, Human (Sf9) UBE2E3; Ubiquitin-conjugating enzyme E2 E3; E2 ubiquitin-conjugating enzyme E3; UbcH9; Ubiquitin carrier protein E3; Ubiquitin-conjugating enzyme E2-23 kDa; Ubiquitin-protein ligase E3	Human	Sf9 insect cells
	UB2E3 protein is a key ubiquitin-proteasome system component. As an E2 ubiquitin-conjugating enzyme, it plays a crucial role in the attachment of ubiquitin to target proteins. In vitro, UB2E3 exhibits diverse catalytic abilities, promoting polyubiquitination of “Lys-11,” “Lys-48,” and “Lys-63” linkages, suggesting its involvement in diverse cellular processes. UB2E3 Protein, Human (Sf9) is the recombinant human-derived UB2E3 protein, expressed by Sf9 insect cells , with tag free. The total length of UB2E3 Protein, Human (Sf9) is 206 a.a., .

HY-P701490

	UB2E3 Protein, Human (Sf9, His, Strep) UBE2E3; Ubiquitin-conjugating enzyme E2 E3; E2 ubiquitin-conjugating enzyme E3; UbcH9; Ubiquitin carrier protein E3; Ubiquitin-conjugating enzyme E2-23 kDa; Ubiquitin-protein ligase E3	Human	Sf9 insect cells
	UB2E3 protein is a key ubiquitin-proteasome system component. As an E2 ubiquitin-conjugating enzyme, it plays a crucial role in the attachment of ubiquitin to target proteins. In vitro, UB2E3 exhibits diverse catalytic abilities, promoting polyubiquitination of “Lys-11,” “Lys-48,” and “Lys-63” linkages, suggesting its involvement in diverse cellular processes. UB2E3 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UB2E3 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UB2E3 Protein, Human (Sf9, His, Strep) is 206 a.a., .

HY-P702810

	PRKN Protein, Mouse (GST) E3 ubiquitin-protein ligase parkin; Parkin; PARK2; Parkin RBR E3 ubiquitin-protein ligase	Mouse	E. coli
	PRKN Protein, Mouse (GST) is the recombinant mouse-derived PRKN, expressed by E. coli , with N-GST labeled tag. ,

HY-P702806

	PRKN Protein, Human (His, SUMO) E3 ubiquitin-protein ligase parkin; Parkin; PARK2; Parkin RBR E3 ubiquitin-protein ligase	Human	E. coli

HY-P702807

	PRKN Protein, Human (sf9, His, Myc) E3 ubiquitin-protein ligase parkin; Parkin; PARK2; Parkin RBR E3 ubiquitin-protein ligase	Human	Sf9 insect cells
	PRKN Protein, Human (sf9, His, Myc) is the recombinant human-derived PRKN, expressed by Sf9 insect cells , with C-Myc, N-10*His labeled tag. ,

HY-P701597

	NOSIP Protein, Human NOSIP; Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase NOSIP; RING-type E3 ubiquitin transferase NOSIP; eNOS-interacting protein	Human	E. coli
	NOSIP is an E3 ubiquitin protein ligase that plays a key role in the normal development of the forebrain, eye, and face. Notably, it catalyzes the monoubiquitination of the serine/threonine protein phosphatase 2A (PP2A) catalytic subunit, specifically PPP2CA/PPP2CB. NOSIP Protein, Human is the recombinant human-derived NOSIP protein, expressed by E. coli , with tag free. The total length of NOSIP Protein, Human is 300 a.a., .

HY-P701513

	SMURF2 Protein, Human SMURF2; E3 ubiquitin-protein ligase SMURF2; hSMURF2; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2	Human	E. coli
	SMURF2 protein is an E3 ubiquitin protein ligase that interacts with SMAD7 to induce ubiquitin-dependent degradation of TGF-β receptors and downregulate TGF-β signaling. This interaction triggers autocatalytic degradation of SMURF2 and is antagonized by AIMP1. SMURF2 Protein, Human is the recombinant human-derived SMURF2 protein, expressed by E. coli , with tag free. The total length of SMURF2 Protein, Human is 747 a.a., .

HY-P701598

	NOSIP Protein, Human (His) NOSIP; Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase NOSIP; RING-type E3 ubiquitin transferase NOSIP; eNOS-interacting protein	Human	E. coli
	NOSIP is an E3 ubiquitin protein ligase that plays a key role in the normal development of the forebrain, eye, and face. Notably, it catalyzes the monoubiquitination of the serine/threonine protein phosphatase 2A (PP2A) catalytic subunit, specifically PPP2CA/PPP2CB. NOSIP Protein, Human (His) is the recombinant human-derived NOSIP protein, expressed by E. coli , with N-6*His labeled tag. The total length of NOSIP Protein, Human (His) is 300 a.a., .

HY-P701552

	RNF135 Protein, Human RNF135; E3 ubiquitin-protein ligase RNF135; RIG-I E3 ubiquitin ligase; REUL; RING finger protein 135; RING finger protein leading to RIG-I activation; Riplet; RING-type E3 ubiquitin transferase RNF135	Human	E. coli
	The RNF135 protein acts as an E2-dependent E3 ubiquitin protein ligase and serves as a RIGI coreceptor for viral RNA sensing and activation of antiviral innate immune responses. RNF135 Protein, Human is the recombinant human-derived RNF135 protein, expressed by E. coli , with tag free. The total length of RNF135 Protein, Human is 431 a.a., .

HY-P701553

	RNF135 Protein, Human (His) RNF135; E3 ubiquitin-protein ligase RNF135; RIG-I E3 ubiquitin ligase; REUL; RING finger protein 135; RING finger protein leading to RIG-I activation; Riplet; RING-type E3 ubiquitin transferase RNF135	Human	E. coli
	The RNF135 protein acts as an E2-dependent E3 ubiquitin protein ligase and serves as a RIGI coreceptor for viral RNA sensing and activation of antiviral innate immune responses. RNF135 Protein, Human (His) is the recombinant human-derived RNF135 protein, expressed by E. coli , with N-6*His labeled tag. The total length of RNF135 Protein, Human (His) is 431 a.a., .

HY-P701556

	RNF146 Protein, Human RNF146; E3 ubiquitin-protein ligase RNF146; Dactylidin; Iduna; RING finger protein 146; RING-type E3 ubiquitin transferase RNF146	Human	E. coli
	RNF146 protein is an E3 ubiquitin protein ligase that specifically recognizes and binds poly-ADP-ribosylated (PARsylated) proteins and coordinates their ubiquitination and degradation. Its critical roles span cell survival, DNA damage response, and activation of Wnt signaling. RNF146 Protein, Human is the recombinant human-derived RNF146 protein, expressed by E. coli , with tag free. The total length of RNF146 Protein, Human is 358 a.a., .

HY-P701564

	RNF8 Protein, Human RNF8; E3 ubiquitin-protein ligase RNF8; hRNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8	Human	E. coli
	RNF8 protein is an important E3 ubiquitin protein ligase that participates in the recruitment of repair proteins through "Lys-63" linked histone ubiquitination and "Lys-48" linked ubiquitination to clear damage sites. target protein, thereby participating in DNA damage signaling. RNF8 is recruited by ATM-phosphorylated MDC1 to form ionizing radiation-induced foci of TP53BP1 and BRCA1 at double-strand breaks. RNF8 Protein, Human is the recombinant human-derived RNF8 protein, expressed by E. coli , with tag free. The total length of RNF8 Protein, Human is 484 a.a., .

HY-P702075

	PELI2 Protein, Human PELI2; E3 ubiquitin-protein ligase pellino homolog 2; Pellino-2; RING-type E3 ubiquitin transferase pellino homolog 2	Human	E. coli
	PELI2 protein is an E3 ubiquitin ligase that links ubiquitin to substrate proteins. PELI2 Protein, Human is the recombinant human-derived PELI2 protein, expressed by E. coli , with tag free. The total length of PELI2 Protein, Human is 419 a.a., .

HY-P78030

	RNF43 Protein, Mouse (HEK293, Fc) E3 ubiquitin-protein ligase RNF43; RING finger protein 43; RING-type E3 ubiquitin transferase RNF43; Rnf43	Mouse	HEK293
	RNF43 Protein, a receptor tyrosine kinase, regulates the Wnt signaling pathway by promoting the degradation of Frizzled receptors. It plays a crucial role in embryonic development and tissue homeostasis. Dysregulation of RNF43 Protein is associated with various cancers, making it a potential therapeutic target in cancer treatment. RNF43 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived RNF43 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P701557

	RNF146 Protein, Human (His) RNF146; E3 ubiquitin-protein ligase RNF146; Dactylidin; Iduna; RING finger protein 146; RING-type E3 ubiquitin transferase RNF146	Human	E. coli
	RNF146 protein is an E3 ubiquitin protein ligase that specifically recognizes and binds poly-ADP-ribosylated (PARsylated) proteins and coordinates their ubiquitination and degradation. Its critical roles span cell survival, DNA damage response, and activation of Wnt signaling. RNF146 Protein, Human (His) is the recombinant human-derived RNF146 protein, expressed by E. coli , with N-6*His labeled tag. The total length of RNF146 Protein, Human (His) is 358 a.a., .

HY-P701565

	RNF8 Protein, Human (His) RNF8; E3 ubiquitin-protein ligase RNF8; hRNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8	Human	E. coli
	RNF8 protein is an important E3 ubiquitin protein ligase that participates in the recruitment of repair proteins through "Lys-63" linked histone ubiquitination and "Lys-48" linked ubiquitination to clear damage sites. target protein, thereby participating in DNA damage signaling. RNF8 is recruited by ATM-phosphorylated MDC1 to form ionizing radiation-induced foci of TP53BP1 and BRCA1 at double-strand breaks. RNF8 Protein, Human (His) is the recombinant human-derived RNF8 protein, expressed by E. coli , with N-6*His labeled tag. The total length of RNF8 Protein, Human (His) is 484 a.a., .

HY-P701540

	CHFR Protein, Human CHFR; E3 ubiquitin-protein ligase CHFR; Checkpoint with forkhead and RING finger domains protein; RING finger protein 196; RING-type E3 ubiquitin transferase CHFR	Human	E. coli
	The CHFR protein is an E3 ubiquitin protein ligase that delays mitosis by microtubule toxicants. CHFR Protein, Human is the recombinant human-derived CHFR protein, expressed by E. coli , with tag free. The total length of CHFR Protein, Human is 663 a.a., .

HY-P701595

	NEDD4L Protein, Human NEDD4L; E3 ubiquitin-protein ligase NEDD4-like; HECT-type E3 ubiquitin transferase NED4L; NEDD4.2; Nedd4-2	Human	E. coli
	The NEDD4L protein is an E3 ubiquitin protein ligase that regulates multiple signaling pathways, including autophagy, innate immunity, and DNA repair. NEDD4L Protein, Human is the recombinant human-derived NEDD4L protein, expressed by E. coli , with tag free. The total length of NEDD4L Protein, Human is 974 a.a., .

HY-P701541

	CHFR Protein, Human (His) CHFR; E3 ubiquitin-protein ligase CHFR; Checkpoint with forkhead and RING finger domains protein; RING finger protein 196; RING-type E3 ubiquitin transferase CHFR	Human	E. coli
	The CHFR protein is an E3 ubiquitin protein ligase that delays mitosis by microtubule toxicants. CHFR Protein, Human (His) is the recombinant human-derived CHFR protein, expressed by E. coli , with N-6*His labeled tag. The total length of CHFR Protein, Human (His) is 663 a.a., .

HY-P701596

	NEDD4L Protein, Human (His) NEDD4L; E3 ubiquitin-protein ligase NEDD4-like; HECT-type E3 ubiquitin transferase NED4L; NEDD4.2; Nedd4-2	Human	E. coli
	The NEDD4L protein is an E3 ubiquitin protein ligase that regulates multiple signaling pathways, including autophagy, innate immunity, and DNA repair. NEDD4L Protein, Human (His) is the recombinant human-derived NEDD4L protein, expressed by E. coli , with N-6*His labeled tag. The total length of NEDD4L Protein, Human (His) is 974 a.a., .

HY-P701522

	DTX3 Protein, Human DTX3; Probable E3 ubiquitin-protein ligase DTX3; Protein deltex-3; Deltex3; RING finger protein 154; RING-type E3 ubiquitin transferase DTX3	Human	E. coli
	The DTX3 protein is a multifunctional regulator of Notch signaling that regulates intercellular communication and cell fate decisions. Its effects are context-dependent, exhibiting positive and negative regulation depending on the developmental and cellular environment. DTX3 Protein, Human is the recombinant human-derived DTX3 protein, expressed by E. coli , with tag free. The total length of DTX3 Protein, Human is 346 a.a., .

HY-P701503

	TRIM2 Protein, Human TRIM2; Tripartite motif-containing protein 2; E3 ubiquitin-protein ligase TRIM2; RING finger protein 86; RING-type E3 ubiquitin transferase TRIM2	Human	E. coli
	TRIM2, an UBE2D1-dependent E3 ubiquitin-protein ligase, mediates the ubiquitination of NEFL and phosphorylated BCL2L11. Beyond its ligase role, TRIM2 has neuroprotective functions and aids neuronal rapid ischemic tolerance. It crucially participates in antiviral immunity, restricting New World arenavirus infection. This highlights TRIM2's multifaceted involvement in cellular processes beyond ubiquitin-mediated protein degradation. TRIM2 Protein, Human is the recombinant human-derived TRIM2 protein, expressed by E. coli , with tag free. The total length of TRIM2 Protein, Human is 743 a.a., .

HY-P701523

	DTX3 Protein, Human (GST) DTX3; Probable E3 ubiquitin-protein ligase DTX3; Protein deltex-3; Deltex3; RING finger protein 154; RING-type E3 ubiquitin transferase DTX3	Human	E. coli
	The DTX3 protein is a multifunctional regulator of Notch signaling that regulates intercellular communication and cell fate decisions. Its effects are context-dependent, exhibiting positive and negative regulation depending on the developmental and cellular environment. DTX3 Protein, Human (GST) is the recombinant human-derived DTX3 protein, expressed by E. coli , with N-GST labeled tag. The total length of DTX3 Protein, Human (GST) is 346 a.a., .

HY-P701527

	HERC2 Protein, Human (His) HERC2; E3 ubiquitin-protein ligase HERC2; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2	Human	E. coli
	The HERC2 protein is an E3 ubiquitin protein ligase that tightly regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes, especially in response to ionizing radiation (IR). HERC2 is recruited to DNA damage sites and promotes the assembly of UBE2N and RNF8, promoting "Lys-63" linked ubiquitin chains to produce DNA damage-induced responses. HERC2 Protein, Human (His) is the recombinant human-derived HERC2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HERC2 Protein, Human (His) is 371 a.a., .

HY-P702078

	RNF4 Protein, Human RNF4; E3 ubiquitin-protein ligase RNF4; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein; Protein SNURF	Human	E. coli
	RNF4 protein is an E3 ubiquitin protein ligase that can uniquely bind and ubiquitinate polyubiquitination chains, mediating "Lys-6", "Lys-11", "Lys-48" and "Lys- 63"-linked polyubiquitination to promote proteasomal degradation. Its multiple substrates, including PML and PEA3, regulate various cellular processes. RNF4 Protein, Human is the recombinant human-derived RNF4 protein, expressed by E. coli , with tag free. The total length of RNF4 Protein, Human is 71 a.a., .

HY-P701502

	TRIM2 Protein, Human (GST) TRIM2; Tripartite motif-containing protein 2; E3 ubiquitin-protein ligase TRIM2; RING finger protein 86; RING-type E3 ubiquitin transferase TRIM2	Human	E. coli
	TRIM2, an UBE2D1-dependent E3 ubiquitin-protein ligase, mediates the ubiquitination of NEFL and phosphorylated BCL2L11. Beyond its ligase role, TRIM2 has neuroprotective functions and aids neuronal rapid ischemic tolerance. It crucially participates in antiviral immunity, restricting New World arenavirus infection. This highlights TRIM2's multifaceted involvement in cellular processes beyond ubiquitin-mediated protein degradation. TRIM2 Protein, Human (GST) is the recombinant human-derived TRIM2 protein, expressed by E. coli , with N-GST labeled tag. The total length of TRIM2 Protein, Human (GST) is 743 a.a., .

HY-P702079

	RNF4 Protein, Human (GST) RNF4; E3 ubiquitin-protein ligase RNF4; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein; Protein SNURF	Human	E. coli
	RNF4 protein is an E3 ubiquitin protein ligase that can uniquely bind and ubiquitinate polyubiquitination chains, mediating "Lys-6", "Lys-11", "Lys-48" and "Lys- 63"-linked polyubiquitination to promote proteasomal degradation. Its multiple substrates, including PML and PEA3, regulate various cellular processes. RNF4 Protein, Human (GST) is the recombinant human-derived RNF4 protein, expressed by E. coli , with N-GST labeled tag. The total length of RNF4 Protein, Human (GST) is 71 a.a., .

HY-P702080

	ZNRF2 Protein, Human ZNRF2; E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; RING-type E3 ubiquitin transferase ZNRF2; Zinc/RING finger protein 2	Human	E. coli
	ZNRF2 protein is an E3 ubiquitin protein ligase that plays a crucial role in neuronal transmission and plasticity. It ubiquitinates Na(+)/K(+) ATPase α-1 subunit/ATP1A1, affecting its endocytosis or degradation, which is critical for neuronal function. ZNRF2 Protein, Human is the recombinant human-derived ZNRF2 protein, expressed by E. coli , with tag free. The total length of ZNRF2 Protein, Human is 241 a.a., .

HY-P75894A

	ITCH/AIP4 Protein, Human E3 ubiquitin-protein ligase Itchy homolog; AIP4; NAPP1; ITCH	Human	E. coli
	ITCH/AIP4 protein is an E3 ubiquitin protein ligase that catalyzes the conjugation of “Lys-29”, “Lys-48” and “Lys-63” linked ubiquitin, affecting inflammatory signaling pathways. It forms a ubiquitin editing complex that promotes RIPK1 degradation and terminates TNF- or LPS-mediated NFKB1 activation. ITCH/AIP4 Protein, Human is the recombinant human-derived ITCH/AIP4 protein, expressed by E. coli , with tag free.

HY-P702764

	CBLC Protein, Human (sf9) E3 ubiquitin-protein ligase CBL-C; CBLC; CBL3; RNF57	Human	Sf9 insect cells
	CBLC protein is an E3 ubiquitin-protein ligase that plays a crucial regulatory role in the ubiquitin-proteasome system by accepting ubiquitin from specific E2 enzymes and promoting substrate degradation. It forms a functional complex with UB2D1, UB2D2 and UB2D3. CBLC Protein, Human (sf9) is the recombinant human-derived CBLC, expressed by Sf9 insect cells , with tag Free labeled tag. The total length of CBLC Protein, Human (sf9) is 473 a.a.,

HY-P701593

	MDM2 Protein, Human MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2	Human	E. coli
	MDM2 protein is a key E3 ubiquitin protein ligase that coordinates cellular processes by ubiquitinating and degrading p53/TP53 and inhibiting its tumor suppressor function. In addition to p53/TP53 regulation, MDM2 inhibits p53/TP53- and p73/TP73-mediated responses, self-ubiquitinates, and targets ARRB1 for degradation. MDM2 Protein, Human is the recombinant human-derived MDM2 protein, expressed by E. coli , with tag free. The total length of MDM2 Protein, Human is 95 a.a., with molecular weight of 11.1 kDa.

HY-P702081

	ZNRF2 Protein, Human (His) ZNRF2; E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; RING-type E3 ubiquitin transferase ZNRF2; Zinc/RING finger protein 2	Human	E. coli
	ZNRF2 protein is an E3 ubiquitin protein ligase that plays a crucial role in neuronal transmission and plasticity. It ubiquitinates Na(+)/K(+) ATPase α-1 subunit/ATP1A1, affecting its endocytosis or degradation, which is critical for neuronal function. ZNRF2 Protein, Human (His) is the recombinant human-derived ZNRF2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ZNRF2 Protein, Human (His) is 241 a.a., .

HY-P701548

	RNF114 Protein, Human RNF114; E3 ubiquitin-protein ligase RNF114; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; Zinc finger protein 228; Zinc finger protein 313	Human	E. coli
	The RNF114 protein is an E3 ubiquitin protein ligase that critically regulates a variety of cellular processes by ubiquitinating various substrates. RNF114 is involved in cell cycle progression, apoptosis, osteoclastogenesis and immunity, serving as a negative regulator of NF-kappa-B-dependent transcription, affecting immune responses by ubiquitinating TNFAIP3 and potentially TRAF6. RNF114 Protein, Human is the recombinant human-derived RNF114 protein, expressed by E. coli , with tag free. The total length of RNF114 Protein, Human is 227 a.a., .

HY-P701594

	MDM2 Protein, Human (His) MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2	Human	E. coli
	MDM2 protein is a key E3 ubiquitin protein ligase that coordinates cellular processes by ubiquitinating and degrading p53/TP53 and inhibiting its tumor suppressor function. In addition to p53/TP53 regulation, MDM2 inhibits p53/TP53- and p73/TP73-mediated responses, self-ubiquitinates, and targets ARRB1 for degradation. MDM2 Protein, Human (His) is the recombinant human-derived MDM2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of MDM2 Protein, Human (His) is 95 a.a., .

HY-P702072

	DTX3L Protein, Human DTX3L; E3 ubiquitin-protein ligase DTX3L; B-lymphoma- and BAL-associated protein; Protein deltex-3-like; RING-type E3 ubiquitin transferase DTX3L; Rhysin-2; Rhysin2	Human	E. coli
	DTX3L protein is an E3 ubiquitin protein ligase that cooperates with PARP9 in DNA damage repair and antiviral responses. It monoubiquitylates histones (H2A, H2B, H3, H4), especially “Lys-91” of H4, possibly signaling additional modifications. DTX3L Protein, Human is the recombinant human-derived DTX3L protein, expressed by E. coli , with tag free. The total length of DTX3L Protein, Human is 739 a.a., .

HY-P73485

	XIAP Protein, Human (Avi) E3 ubiquitin-protein ligase XIAP; ILP; IAP-3; XIAP; API3; BIRC4	Human	E. coli
	XIAP protein is a multifunctional regulator that controls apoptosis, inflammation, immunity, copper homeostasis, and various signaling pathways. As a caspase inhibitor, it blocks CASP3 and CASP7 substrate access, keeping CASP9 inactive. XIAP Protein, Human (Avi) is the recombinant human-derived XIAP protein, expressed by E. coli , with C-Avi labeled tag. The total length of XIAP Protein, Human (Avi) is 236 a.a., with molecular weight of ~29.1 kDa.

HY-P73537

	XIAP Protein, Human (His) E3 ubiquitin-protein ligase XIAP; ILP; IAP-3; XIAP; API3; BIRC4	Human	E. coli
	XIAP protein is a multifunctional regulator that controls apoptosis, inflammation, immunity, copper homeostasis, and various signaling pathways. As a caspase inhibitor, it blocks CASP3 and CASP7 substrate access, keeping CASP9 inactive. XIAP Protein, Human (His) is the recombinant human-derived XIAP protein, expressed by E. coli , with N-His labeled tag. The total length of XIAP Protein, Human (His) is 105 a.a., with molecular weight of ~14.8 kDa.

HY-P75894

	ITCH/AIP4 Protein, Human (solution) E3 ubiquitin-protein ligase Itchy homolog; AIP4; NAPP1; ITCH	Human	E. coli
	The ITCH/AIP4 protein, a member of the Nedd4 family of ubiquitin ligases, transfers ubiquitin to protein substrates for lysosomal degradation. It regulates cell differentiation and immune responses and is associated with autoimmune disease. Alternative splicing produces multiple isoforms. ITCH/AIP4 is expressed ubiquitously, with notable levels in the testis, esophagus, and 25 other tissues. ITCH/AIP4 Protein, Human (solution) is the recombinant human-derived ITCH/AIP4 protein, expressed by E. coli , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes).

HY-P701510

	TRIM69 Protein, Human (GST) TRIM69; E3 ubiquitin-protein ligase TRIM69; RFP-like domain-containing protein trimless; RING finger protein 36; RING-type E3 ubiquitin transferase TRIM69; Tripartite motif-containing protein 69	Human	E. coli
	TRIM69 protein is an E3 ubiquitin ligase that limits viral infection (such as dengue virus, Indiana vesicular stomatitis virus) by ubiquitinating viral proteins such as dengue virus NS3, thereby limiting infection. TRIM69 Protein, Human (GST) is the recombinant human-derived TRIM69 protein, expressed by E. coli , with N-GST labeled tag. The total length of TRIM69 Protein, Human (GST) is 499 a.a., .

HY-P701511

	TRIM69 Protein, Human TRIM69; E3 ubiquitin-protein ligase TRIM69; RFP-like domain-containing protein trimless; RING finger protein 36; RING-type E3 ubiquitin transferase TRIM69; Tripartite motif-containing protein 69	Human	E. coli
	TRIM69 protein is an E3 ubiquitin ligase that limits viral infection (such as dengue virus, Indiana vesicular stomatitis virus) by ubiquitinating viral proteins such as dengue virus NS3, thereby limiting infection. TRIM69 Protein, Human is the recombinant human-derived TRIM69 protein, expressed by E. coli , with tag free. The total length of TRIM69 Protein, Human is 499 a.a., .

HY-P701549

	RNF114 Protein, Human (GST) RNF114; E3 ubiquitin-protein ligase RNF114; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; Zinc finger protein 228; Zinc finger protein 313	Human	E. coli
	The RNF114 protein is an E3 ubiquitin protein ligase that critically regulates a variety of cellular processes by ubiquitinating various substrates. RNF114 is involved in cell cycle progression, apoptosis, osteoclastogenesis and immunity, serving as a negative regulator of NF-kappa-B-dependent transcription, affecting immune responses by ubiquitinating TNFAIP3 and potentially TRAF6. RNF114 Protein, Human (GST) is the recombinant human-derived RNF114 protein, expressed by E. coli , with N-GST labeled tag. The total length of RNF114 Protein, Human (GST) is 227 a.a., .

HY-P702073

	DTX3L Protein, Human (His) DTX3L; E3 ubiquitin-protein ligase DTX3L; B-lymphoma- and BAL-associated protein; Protein deltex-3-like; RING-type E3 ubiquitin transferase DTX3L; Rhysin-2; Rhysin2	Human	E. coli
	DTX3L protein is an E3 ubiquitin protein ligase that cooperates with PARP9 in DNA damage repair and antiviral responses. It monoubiquitylates histones (H2A, H2B, H3, H4), especially “Lys-91” of H4, possibly signaling additional modifications. DTX3L Protein, Human (His) is the recombinant human-derived DTX3L protein, expressed by E. coli , with N-6*His labeled tag. The total length of DTX3L Protein, Human (His) is 739 a.a., .

HY-P74343

	CBLC Protein, Human (sf9, His-GST) E3 ubiquitin-protein ligase CBL-C; CBLC; CBL3; RNF57	Human	Sf9 insect cells
	CBLC protein is an E3 ubiquitin-protein ligase that plays a crucial regulatory role in the ubiquitin-proteasome system by accepting ubiquitin from specific E2 enzymes and promoting substrate degradation. It forms a functional complex with UB2D1, UB2D2 and UB2D3. CBLC Protein, Human (sf9, His-GST) is the recombinant human-derived CBLC protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P701560

	RNF181 Protein, Human RNF181; E3 ubiquitin-protein ligase RNF181; RING finger protein 181	Human	E. coli
	RNF181 Protein, an E3 ubiquitin-protein ligase, mediates the monoubiquitination of the 26S proteasome subunit PSMC2/RPT1. This suggests a role in regulating the 26S proteasome, a vital cellular machinery for protein degradation. RNF181's capacity to modulate PSMC2/RPT1 implies involvement in the intricate regulatory network governing cellular protein homeostasis. RNF181 Protein, Human is the recombinant human-derived RNF181 protein, expressed by E. coli , with tag free. The total length of RNF181 Protein, Human is 152 a.a., .

HY-P701561

	RNF181 Protein, Human (His) RNF181; E3 ubiquitin-protein ligase RNF181; RING finger protein 181	Human	E. coli
	RNF181 Protein, an E3 ubiquitin-protein ligase, mediates the monoubiquitination of the 26S proteasome subunit PSMC2/RPT1. This suggests a role in regulating the 26S proteasome, a vital cellular machinery for protein degradation. RNF181's capacity to modulate PSMC2/RPT1 implies involvement in the intricate regulatory network governing cellular protein homeostasis. RNF181 Protein, Human (His) is the recombinant human-derived RNF181 protein, expressed by E. coli , with N-6*His labeled tag. The total length of RNF181 Protein, Human (His) is 152 a.a., .

HY-P702365

	MARCH2 Protein, Human (Cell-Free, His, SUMO) E3 ubiquitin-protein ligase MARCHF2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; MARCH-II; RING finger protein 172; RING-type E3 ubiquitin transferase MARCHF2	Human	E. coli Cell-free
	The MARCH2 protein acts as an E3 ubiquitin protein ligase, promoting endocytosis and sorting of TFRC and CD86 to lysosomes. MARCH2 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived MARCH2 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of MARCH2 Protein, Human (Cell-Free, His, SUMO) is 246 a.a., with molecular weight of 43 kDa.

HY-P75970

	Pellino-1 Protein, Human (sf9, His-GST) E3 ubiquitin-protein ligase pellino homolog 1; PELI1; PRISM	Human	Sf9 insect cells
	Pellino-1 protein is an E3 ubiquitin ligase that links ubiquitin to substrate proteins. Pellino-1 Protein, Human (sf9, His-GST) is the recombinant human-derived Pellino-1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Pellino-1 Protein, Human (sf9, His-GST) is 418 a.a., with molecular weight of ~74.1 kDa.

HY-P77151

	PPIL2 Protein, Human (His) RING-type E3 ubiquitin-protein ligase PPIL2; CYC4; Cyp60; Rotamase PPIL2	Human	E. coli
	PPIL2 exhibits ubiquitin-protein ligase activity, acting as an E3 ligase or ubiquitin-ubiquitin ligase, promoting “Lys-48”-linked polyubiquitination for proteasomal degradation of substrates.It acts as a chaperone to help transport BSG/Basigin to the cell membrane.PPIL2 Protein, Human (His) is the recombinant human-derived PPIL2 protein, expressed by E.coli , with N-His labeled tag.

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Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
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Appearance
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Storage & Stability
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Free Sample	Yes No
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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83705

	MDM2 Antibody (YA3442) ACTFS antibody; Double minute 2 protein antibody; E3 ubiquitin-protein ligase Mdm2 antibody; Hdm 2 antibody; Hdm2 antibody; HDMX antibody; MDM 2 antibody; MDM2 antibody; MDM2 oncogene E3 ubiquitin protein ligase antibody; Mdm2 p53 E3 ubiquitin protein ligase homolog antibody; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody; MDM2_HUMAN antibody; MDM2BP antibody; Mouse Double Minute 2 antibody; MTBP antibody; Murine Double Minute Chromosome 2 antibody; Oncoprotein Mdm2 antibody; p53 Binding Protein Mdm2 antibody; p53-binding protein Mdm2 antibody; Ubiquitin protein ligase E3 Mdm2 antibody; Ubiquitin protein ligase E3 Mdm2 antibody	WB, IHC-P, ICC/IF	Human, Monkey
	MDM2 Antibody (YA3442) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA3442), targeting MDM2, with a predicted molecular weight of 55 kDa (observed band size: 90 kDa). MDM2 Antibody (YA3442) can be used for WB, ICC/IF, IHC-P experiment in human, monkey background.

HY-P80919

	TRAF6 Antibody TRAF6; RNF85; TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85	WB	Human, Rat
	TRAF6 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 60 kDa, targeting to TRAF6. It can be used for WB assays with tag free, in the background of Human, Rat.

HY-P81763

	Transcription Factor E3 Antibody (YA1508) TFE3; BHLHE33; Transcription factor E3; Class E basic helix-loop-helix protein 33; bHLHE33	IHC-P, ICC/IF, FC	Human
	Transcription Factor E3 Antibody (YA1508) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1508), targeting Transcription Factor E3. Transcription Factor E3 Antibody (YA1508) can be used for IHC-P, ICC/IF, FC experiment in human background.

HY-P82181

	EGR2 Antibody (YA1926) EGR2; KROX20; E3 SUMO-protein ligase EGR2; AT591; E3 SUMO-protein transferase ERG2 Curated; Early growth response protein 2 (EGR-2); Zinc finger protein Krox-20;	WB	Human, Mouse, Rat
	EGR2 Antibody (YA1926) is a biotin-conjugated non-conjugated IgG antibody, targeting EGR2, with a predicted molecular weight of 50 kDa (observed band size: 53 kDa). EGR2 Antibody (YA1926) can be used for WB experiment in human, mouse, rat background.

HY-P81834

	ZNF364 Antibody (YA1579) E3 ubiquitin-protein ligase RNF115; Rabring 7; Zinc finger protein 364	WB	Human, Rat
	ZNF364 Antibody (YA1579) is a biotin-conjugated non-conjugated IgG antibody, targeting ZNF364, with a predicted molecular weight of 34 kDa (observed band size: 34 kDa). ZNF364 Antibody (YA1579) can be used for WB experiment in human, rat background.

HY-P81830

	Pellino 1 Antibody (YA1575) Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1	WB, IP	Human, Rat
	Pellino 1 Antibody (YA1575) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1575), targeting Pellino 1, with a predicted molecular weight of 46 kDa (observed band size: 46 kDa). Pellino 1 Antibody (YA1575) can be used for WB, IP experiment in human, rat background.

HY-P83135

	RNF20 Antibody (YA2880) BRE1-A; hBRE1; RING finger protein 20; E3 ubiquitin-protein ligase BRE1A; RNF20	WB, ICC/IF, IP, FC	Human, Mouse
	RNF20 Antibody (YA2880) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2880), targeting RNF20, with a predicted molecular weight of 114 kDa (observed band size: 114 kDa). RNF20 Antibody (YA2880) can be used for WB, ICC/IF, IP, FC experiment in human, mouse background.

HY-P83446

	ZNRF2 Antibody (YA3191) E3 ubiquitin-protein ligase ZNRF2; ZNRF2; Zinc/RING finger protein 2; RNF202; Protein Ells2	WB, IHC-P	Human, Mouse, Rat
	ZNRF2 Antibody (YA3191) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3191), targeting ZNRF2, with a predicted molecular weight of 24 kDa (observed band size: 24 kDa). ZNRF2 Antibody (YA3191) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P82878

	ITCH Antibody (YA2623) ITCH; E3 ubiquitin-protein ligase Itchy homolog; Itch; Atrophin-1-interacting protein 4; AIP4; NFE2-associated polypeptide 1; NAPP1	WB, IHC-P	Human, Mouse, Rat
	ITCH Antibody (YA2623) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2623), targeting ITCH, with a predicted molecular weight of 103 kDa (observed band size: 103 kDa). ITCH Antibody (YA2623) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P83322

	Rad18 Antibody (YA3067) E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; RAD18; RAD18; S. cerevisiae; homolog; RING finger protein 73; RNF73	WB, FC	Human, Mouse, Rat
	Rad18 Antibody (YA3067) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3067), targeting Rad18, with a predicted molecular weight of 56 kDa (observed band size: 70 kDa). Rad18 Antibody (YA3067) can be used for WB, FC experiment in human, mouse, rat background.

HY-P81379

	RBX1 Antibody (YA1124) ROC1; RNF75; RBX1; E3 ubiquitin-protein ligase RBX1; RING finger protein 75; RING-box protein 1 (Rbx1)	IHC-P	Human
	RBX1 Antibody (YA1124) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1124), targeting RBX1. RBX1 Antibody (YA1124) can be used for IHC-P experiment in human background.

HY-P82647

	CBL Antibody (YA2392) CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL	WB, ICC/IF, IP	Human
	CBL Antibody (YA2392) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2392), targeting CBL, with a predicted molecular weight of 100 kDa (observed band size: 120 kDa). CBL Antibody (YA2392) can be used for WB, ICC/IF, IP experiment in human background.

HY-P82146

	MIB1 Antibody (YA1891) Dip1; LVNC7; MIB; mib1; ZZANK2; ZZZ6; DAPK-interacting protein 1; Mind bomb homolog 1; RING-type E3 ubiquitin transferase MIB1	WB, IHC-P, ICC/IF	Human, Mouse
	MIB1 Antibody (YA1891) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1891), targeting MIB1, with a predicted molecular weight of 110 kDa (observed band size: 110 kDa). MIB1 Antibody (YA1891) can be used for WB, IHC-P, ICC/IF experiment in human, mouse background.

HY-P83471

	RNF14 Antibody (YA3216) RNF14; ARA54; HRIHFB2038; E3 ubiquitin-protein ligase RNF14; Androgen receptor-associated protein 54; HFB30; RING finger protein 14; Triad2 protein	WB	Human, Mouse, Rat
	RNF14 Antibody (YA3216) is a biotin-conjugated non-conjugated IgG antibody, targeting RNF14, with a predicted molecular weight of 54 kDa (observed band size: 54 kDa). RNF14 Antibody (YA3216) can be used for WB experiment in human, mouse, rat background.

HY-P81294

	Phospho-CBL (Tyr774) Antibody (YA1014) CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL	WB, IP	Human, Rat
	Phospho-CBL (Tyr774) Antibody (YA1014) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1014), targeting Phospho-CBL (Tyr774), with a predicted molecular weight of 100 kDa (observed band size: 120 kDa). Phospho-CBL (Tyr774) Antibody (YA1014) can be used for WB, IP experiment in human, rat background.

HY-P81294A

	Phospho-CBL (Ser669) Antibody (YA1015) CBL; CBL2; RNF55; E3 ubiquitin-protein ligase CBL; Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL	WB	Human
	Phospho-CBL (Ser669) Antibody (YA1015) is a biotin-conjugated non-conjugated IgG antibody, targeting Phospho-CBL (Ser669), with a predicted molecular weight of 100 kDa (observed band size: 120 kDa). Phospho-CBL (Ser669) Antibody (YA1015) can be used for WB experiment in human background.

HY-P82472

	PIAS1 Antibody (YA2217) PIAS1; DDXBP1; E3 SUMO-protein ligase PIAS1; DEAD/H box-binding protein 1; Gu-binding protein; GBP; Protein inhibitor of activated STAT protein 1; RNA helicase II-binding protein	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	PIAS1 Antibody (YA2217) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2217), targeting PIAS1, with a predicted molecular weight of 72 kDa (observed band size: 76 kDa). PIAS1 Antibody (YA2217) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P81998

	Pirh2 Antibody (YA1743) RCHY1; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; RING finger and CHY zinc finger domain-containing protein 1; Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger	WB	Human
	Pirh2 Antibody (YA1743) is a biotin-conjugated non-conjugated IgG antibody, targeting Pirh2, with a predicted molecular weight of 30 kDa (observed band size: 30 kDa). Pirh2 Antibody (YA1743) can be used for WB experiment in human background.

HY-P82533

	TRIM25 Antibody (YA2278) TRIM25; EFP; RNF147; ZNF147; E3 ubiquitin/ISG15 ligase TRIM25; Estrogen-responsive finger protein; RING finger protein 147; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147	WB, ICC/IF, IP	Human, Rat
	TRIM25 Antibody (YA2278) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2278), targeting TRIM25, with a predicted molecular weight of 71 kDa (observed band size: 71 kDa). TRIM25 Antibody (YA2278) can be used for WB, ICC/IF, IP experiment in human, rat background.

HY-P80730

	KAP1 Antibody TRIM28; KAP1; RNF96; TIF1B; Transcription intermediary factor 1-beta; TIF1-beta; E3 SUMO-protein ligase TRIM28; KRAB-associated protein 1; KAP-1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; RING finger protein 96; Tripart	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	KAP1 Antibody (YA719) is a non-conjugated and Rabbit origined monoclonal antibody about 89 kDa, targeting to KAP1. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human,Mouse,Rat.

HY-P83561

	Ubiquitin Protein Ligase E3A Antibody (YA3306) Ubiquitin-protein ligase E3A; UBE3A; E6AP; EPVE6AP; HPVE6A	WB, ICC/IF, IP	Human, Mouse, Rat
	Ubiquitin Protein Ligase E3A Antibody (YA3306) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3306), targeting Ubiquitin Protein Ligase E3A, with a predicted molecular weight of 101 kDa (observed band size: 101 kDa). Ubiquitin Protein Ligase E3A Antibody (YA3306) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

HY-P83375

	NSDHL Antibody (YA3120) H105E3; XAP104; SDR31E1	WB, IP	Human
	NSDHL Antibody (YA3120) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3120), targeting NSDHL, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). NSDHL Antibody (YA3120) can be used for WB, IP experiment in human background.

HY-P82242

	SMG1 Antibody (YA1987) 61E3.4; ATX; hSMG1; LIP; smg1	WB	Human, Mouse, Rat
	SMG1 Antibody (YA1987) is a biotin-conjugated non-conjugated IgG antibody, targeting SMG1, with a predicted molecular weight of 411 kDa (observed band size: 411 kDa). SMG1 Antibody (YA1987) can be used for WB experiment in human, mouse, rat background.

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Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-126458

Thalidomide-O-PEG2-propargyl E3 ligase Ligand-Linker Conjugates 32		Alkynes
Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Thalidomide-O-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-103615

Thalidomide-O-amido-C4-N3 1 Publications Verification Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18		Azide
Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-103598

(S,R,S)-AHPC-PEG3-N3 VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12		Azide
(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103599

(S,R,S)-AHPC-PEG2-N3 VH032-PEG2-N3; VHL Ligand-Linker Conjugates 6; E3 ligase Ligand-Linker Conjugates 13		Azide
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103600

(S,R,S)-AHPC-PEG1-N3 VH032-PEG1-N3; VHL Ligand-Linker Conjugates 9; E3 ligase Ligand-Linker Conjugates 3		Azide
(S,R,S)-AHPC-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG1-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103601

(S,R,S)-AHPC-PEG4-N3 VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 4		Azide
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-128832

Nutlin-C1-amido-PEG4-C2-N3 MDM2 Ligand-Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 48		Azide
Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology. Nutlin-C1-amido-PEG4-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-125843

Pomalidomide-PEG1-C2-N3 Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50		Azide
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC₅₀ of 2.1 nM . Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-161132

Lenalidomide 4'-alkyl-C5-azide		Azide
Lenalidomide 4'-alkyl-C5-azide is a functionalized cerebellar ligand for PROTAC development that contains an E3 ligand and an alkyl LC5 ligand with terminal azides that can be coupled to a target protein ligand .

HY-163167

VH 032 amide-alkylC5-azide		Azide
VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .

HY-139332

Pomalidomide 4'-PEG6-azide		Azide
Pomalidomide 4'-PEG6-azide (compound 33e) is the E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs .

HY-160077

Pomalidomide-CO-C5-azide		Azide
Pomalidomide-CO-C5-azide (Compound PA) is a ligand for E3 ligase bearing a bioorthogonal group azide. Pomalidomide-CO-C5-azide can be used to synthesize PROTACs with anticancer activity .

HY-147192

(S,R,S)-AHPC-O-PEG1-propargyl		Alkynes
(S,R,S)-AHPC-O-PEG1-propargyl (Compound 10b) is an E3 ligand for the synthesis of PROTAC . (S,R,S)-AHPC-O-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139343

Pomalidomide 4'-alkylC2-azide		Azide
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .

HY-139341

Pomalidomide 4'-alkylC3-azide		Azide
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .

HY-157510

Thalidomide-O-C3-azide		Azide
Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-157511

Thalidomide-O-C5-azide		Azide
Thalidomide-O-C5-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C5-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C5-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-161832

(S,R,S)-Me-AHPC-amide-C3-alkyne		Alkynes
(S,R,S)-Me-AHPC-amide-C3-alkyne is an E3 ligase ligand-linker conjugate used for the synthesis of JWZ-5-13 (HY-161828) .

HY-157515

Thalidomide 4'-ether-PEG2-azide		Azide
Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-148556

Thalidomide-O-C6-azide		Azide
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)) based cereblon ligand and a linker used in PROTAC technology . Thalidomide-O-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-162948

(S,R,S)-AHPC-PEG2-C5-N3		Azide
(S,R,S)-AHPC-PEG2-C5-N3 is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG2-C5-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-159165

Pomalidomide-cyclopentane-amide-Alkyne		Alkynes
Pomalidomide-cyclopentane-amide-Alkyne is an E3 ligase ligand-linker conjugate that incorporates the Pomalidomide (HY-10984) and the linker cyclopentane-amide-Alkyne. Pomalidomide-cyclopentane-amide-Alkyne is used to form PROTACs, such as RGB110 (HY-159087) .

HY-159608

PROTAC Cbl-b-IN-1		Azide
PROTAC Cbl-b-IN-1 (compound 64) is a PROTAC targeting Cbl-b. PROTAC Cbl-b-IN-1 is composed of PROTAC target protein ligand Cbl-b-IN-21 (HY-159615), PROTAC Linker Cbz-Pip-2C-Pip-C-Pip (HY-159617) and E3 ubiquitin ligase ligand (3S) Lenalidomide-5-Br (HY-W797329), where the E3 ubiquitin ligase ligand + Linker conjugate is (3S) Lenalidomide-5-Pip-C-Pip-2C-Pip (HY-159618) ^{[1] ^.}

HY-163964

Lenalidomide-C3-PEG3-N3		Azide
Lenalidomide-C3-PEG3-N3 is an E3 Ligase Ligand-Linker Conjugate. Lenalidomide-C3-PEG3-N3 can be used to synthesize L18I (HY-163962) .

HY-159777

CPI-203-PEG5-Alkyne		Alkynes
CPI-203-PEG5-Alkyne is a conjugate of E3 ligase and linker. CPI-203-PEG5-Alkyne can be used for synthesis of PROTAC BRD4-DCAF1 degrader-1 (HY-169151) .

HY-140055

Thalidomide-PEG4-Propargyl		Alkynes
Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology . Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-163647

Lenalidomide-COCH-PEG2-azido		Azide
Lenalidomide-COCH-PEG2-azido is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based cereblon ligand and a linker. Lenalidomide-COCH-PEG2-azido can be used in the synthesis of PROTAC AKR1C3 degrader-1 (HY-163609) .

HY-128767

VH032-PEG3-acetylene		Alkynes
VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology . VH032-PEG3-acetylene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101460

Tz-Thalidomide		Tetrazine
Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC₅₀s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .

HY-161793

(S,R,S)-AHPC-NHCO-C-O-C5-N3		Azide
(S,R,S)-AHPC-NHCO-C-O-C5-N3 is a conjugate of ligand for E3 ligase (HY-125845) and linker (HY-161792). (S,R,S)-AHPC-NHCO-C-O-C5-N3 can be utilized for synthesis of PROTAC SARS-CoV-2 Mpro degrader-3 (HY-161789) .

HY-69220

7-Octynoic acid		Alkynes PROTAC Synthesis
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins . 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141015

Pomalidomide-PEG4-azide		Azide
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140844

Thalidomide-O-PEG4-azide		Azide
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-137537

Pomalidomide-PEG2-azide		Azide
Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-137538

Pomalidomide-PEG3-azide		Azide
Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology . Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-132208

Pomalidomide 4'-PEG2-azide		Azide
Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159449

PROTAC SMARCA2 degrader-5		Azide
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-139999

LCL-PEG3-N3		Azide
LCL-PEG3-N3 is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor . LCL-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-139999A

LCL-PEG3-N3 hydrochloride		Azide
LCL-PEG3-N3 (hydrochloride) is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor . LCL-PEG3-N3 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159451

PROTAC SMARCA2 degrader-7		Azide
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2 and SMARCA4 in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-161131

Lenalidomide 4'-alkyl-C3-azide		Azide
Lenalidomide 4'-alkyl-C3-azide (compound 4a) is a click chemical modified Lenalidomide (HY-A0003) that can be used to synthesize PROTACs. Lenalidomide is an orally active immunomodulator and a ligand for the ubiquitin E3 ligase cereblon (CRBN). Lenalidomide 4'-alkyl-C3-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition reactions (SPAAC) can also occur with molecules containing DBCO or BCN groups .

HY-159461

PROTAC SMARCA2/4-degrader-9		Azide
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159460

PROTAC SMARCA2/4-degrader-8		Azide
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades SMARCA2 with DC₅₀ <100 nM in A549 and in MV411, degrades SMARCA4 with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159455

PROTAC SMARCA2/4-degrader-4		Azide
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

PROTAC SMARCA2/4-degrader-5		Azide
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-133139

Lenalidomide-PEG1-azide		Azide
Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2 (HY-133136) . Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-108374

4-Azidobutylamine		PROTAC Synthesis Azide
4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins . 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-133138

Pomalidomide-PEG1-azide		Azide
Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker.?Pomalidomide-PEG1-azide?can be used to design a?PROTAC BRD4 Degrader-1 (HY-133131) . Pomalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130652

Pomalidomide 4'-PEG3-azide		Azide
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach . Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151792

Pomalidomid-C6-PEG3-butyl-N3		PROTAC Synthesis Azide
Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. Pomalidomid-C6-PEG3-butyl-N3 also is a crosslinker-E3 ligase ligand conjugate, which be used in click reactive protein degrader building block for PROTAC research. Pomalidomid-C6-PEG3-butyl-N3 also can be used in the template for synthesis of targeted protein degrader . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-148130A

Rugonersen sodium RG6091 sodium; RO7248824 sodium		Antisense Oligonucleotides
Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-R00543

hsa-miR-30e-3p mimic		MicroRNAs miRNA mimics
hsa-miR-30e-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-148130

Rugonersen RG6091; RO7248824		Antisense Oligonucleotides
Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-R00009

hsa-let-7e-3p mimic		MicroRNAs miRNA mimics
hsa-let-7e-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R01572

hsa-miR-518e-3p mimic		MicroRNAs miRNA mimics
hsa-miR-518e-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R01593

hsa-miR-519e-3p mimic		MicroRNAs miRNA mimics
hsa-miR-519e-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R01601

hsa-miR-520e-3p mimic		MicroRNAs miRNA mimics
hsa-miR-520e-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R01681

hsa-miR-548e-3p mimic		MicroRNAs miRNA mimics
hsa-miR-548e-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R03049

mmu-miR-344e-3p mimic		MicroRNAs miRNA mimics
mmu-miR-344e-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R03202

mmu-miR-467e-3p mimic		MicroRNAs miRNA mimics
mmu-miR-467e-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R03465

mmu-miR-669e-3p mimic		MicroRNAs miRNA mimics
mmu-miR-669e-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI00009

hsa-let-7e-3p inhibitor		MicroRNAs miRNA inhibitors
hsa-let-7e-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI00543

hsa-miR-30e-3p inhibitor		MicroRNAs miRNA inhibitors
hsa-miR-30e-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI01572

hsa-miR-518e-3p inhibitor		MicroRNAs miRNA inhibitors
hsa-miR-518e-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI01593

hsa-miR-519e-3p inhibitor		MicroRNAs miRNA inhibitors
hsa-miR-519e-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI01601

hsa-miR-520e-3p inhibitor		MicroRNAs miRNA inhibitors
hsa-miR-520e-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI01681

hsa-miR-548e-3p inhibitor		MicroRNAs miRNA inhibitors
hsa-miR-548e-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03049

mmu-miR-344e-3p inhibitor		MicroRNAs miRNA inhibitors
mmu-miR-344e-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03202

mmu-miR-467e-3p inhibitor		MicroRNAs miRNA inhibitors
mmu-miR-467e-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03465

mmu-miR-669e-3p inhibitor		MicroRNAs miRNA inhibitors
mmu-miR-669e-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RS04276

EIF4E3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
EIF4E3 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF4E3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05188

G2E3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
G2E3 Human Pre-designed siRNA Set A contains three designed siRNAs for G2E3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15344

UBE2E3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
UBE2E3 Human Pre-designed siRNA Set A contains three designed siRNAs for UBE2E3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09540

NR2E3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
NR2E3 Human Pre-designed siRNA Set A contains three designed siRNAs for NR2E3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-R00009A

hsa-let-7e-3p agomir		MicroRNAs miRNA agomirs
hsa-let-7e-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R00543A

hsa-miR-30e-3p agomir		MicroRNAs miRNA agomirs
hsa-miR-30e-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01572A

hsa-miR-518e-3p agomir		MicroRNAs miRNA agomirs
hsa-miR-518e-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01593A

hsa-miR-519e-3p agomir		MicroRNAs miRNA agomirs
hsa-miR-519e-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01601A

hsa-miR-520e-3p agomir		MicroRNAs miRNA agomirs
hsa-miR-520e-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01681A

hsa-miR-548e-3p agomir		MicroRNAs miRNA agomirs
hsa-miR-548e-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03049A

mmu-miR-344e-3p agomir		MicroRNAs miRNA agomirs
mmu-miR-344e-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03202A

mmu-miR-467e-3p agomir		MicroRNAs miRNA agomirs
mmu-miR-467e-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03465A

mmu-miR-669e-3p agomir		MicroRNAs miRNA agomirs
mmu-miR-669e-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI00009A

hsa-let-7e-3p antagomir		MicroRNAs miRNA antagomirs
hsa-let-7e-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI00543A

hsa-miR-30e-3p antagomir		MicroRNAs miRNA antagomirs
hsa-miR-30e-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01572A

hsa-miR-518e-3p antagomir		MicroRNAs miRNA antagomirs
hsa-miR-518e-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01593A

hsa-miR-519e-3p antagomir		MicroRNAs miRNA antagomirs
hsa-miR-519e-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01601A

hsa-miR-520e-3p antagomir		MicroRNAs miRNA antagomirs
hsa-miR-520e-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01681A

hsa-miR-548e-3p antagomir		MicroRNAs miRNA antagomirs
hsa-miR-548e-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03049A

mmu-miR-344e-3p antagomir		MicroRNAs miRNA antagomirs
mmu-miR-344e-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03202A

mmu-miR-467e-3p antagomir		MicroRNAs miRNA antagomirs
mmu-miR-467e-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03465A

mmu-miR-669e-3p antagomir		MicroRNAs miRNA antagomirs
mmu-miR-669e-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

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