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Pathways Recommended:	PROTAC

Results for "

PROTAC ligand

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E3 Ligase Ligand-Linker Conjugates (592) Ligands for Target Protein for PROTAC (240) PD-1/PD-L1 (6) PROTAC Linkers (25) PROTAC-Linker Conjugates for PAC (1) Target Protein Ligand-Linker Conjugates (27) 17β-HSD (1) AAK1 (1) Acetyl-CoA Carboxylase (2) ADC Linker (1) Adrenergic Receptor (1) Akt (7) Aldose Reductase (1) Anaplastic lymphoma kinase (ALK) (6) Androgen Receptor (15) Apoptosis (213) ATM/ATR (1) Aurora Kinase (7) Autophagy (204) Bcl-2 Family (11) BCL6 (2) Bcr-Abl (2) Btk (22) c-Met/HGFR (4) c-Myc (6) CaMK (1) Casein Kinase (3) CDK (42) CRM1 (2) Cyclic GMP-AMP Synthase (1) Cyclophilin (4) Cytochrome P450 (5) Dengue Virus (4) Deubiquitinase (1) DNA Methyltransferase (1) DNA/RNA Synthesis (6) Drug Intermediate (1) Drug Isomer (1) DYRK (1) E1/E2/E3 Enzyme (11) Early 2 Factor (E2F) (1) EGFR (13) Epigenetic Reader Domain (118) ERK (2) Estrogen Receptor/ERR (26) FAK (6) Ferroptosis (5) FGFR (4) FKBP (17) Flavivirus (1) FLT3 (12) GLP Receptor (1) Glutathione Peroxidase (3) GSK-3 (1) HCV (2) HDAC (18) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (3) Histone Acetyltransferase (4) Histone Demethylase (5) Histone Methyltransferase (17) HIV (4) HSP (2) IFNAR (1) IKK (1) IKZF Family (1) Indoleamine 2,3-Dioxygenase (IDO) (2) IRAK (10) Isotope-Labeled Compounds (1) Itk (3) JAK (6) JNK (1) Kinesin (2) Ligands for E3 Ligase (230) LIM Kinase (LIMK) (1) LRRK2 (1) MAP3K (1) MAP4K (3) MDM-2/p53 (13) MEK (4) METTL3 (3) Mixed Lineage Kinase (3) Molecular Glues (2) Mps1 (3) mTOR (1) NAMPT (2) NF-κB (3) Nuclear Hormone Receptor 4A/NR4A (1) p38 MAPK (5) PARP (10) PDK-1 (1) PERK (1) Phosphatase (3) PI3K (1) PIN1 (6) Polo-like Kinase (PLK) (1) PROTACs (439) Proteasome (1) Raf (3) RAR/RXR (1) Ras (18) RET (6) RIP kinase (2) ROR (2) ROS Kinase (1) Salt-inducible Kinase (SIK) (1) SARS-CoV (6) SGK (1) Sirtuin (2) SNIPERs (7) STAT (13) STING (7) SWI/SNF Complex (4) Tau Protein (2) Toll-like Receptor (TLR) (1) Trk Receptor (1) Tyrosinase (1) ULK (1) Virus Protease (5) WDR5 (5) Wnt (1) YAP (4) YTHDF (1) α-synuclein (3) β-catenin (1)
By Research Areas:	Cancer (1470) Cardiovascular Disease (2) Endocrinology (3) Infection (28) Inflammation/Immunology (31) Metabolic Disease (7) Neurological Disease (14)
Click Chemistry:	PROTAC Synthesis (12) Azide (57) Alkynes (17)

1588

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: PROTAC Linkers PROTAC-Linker Conjugates for PAC Target Protein Ligand-Linker Conjugates Ligands for Target Protein for PROTAC E3 Ligase Ligand-Linker Conjugates PD-1/PD-L1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115729

PROTAC CDK9 ligand-1	Ligands for Target Protein for PROTAC	Cancer
PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.

HY-139304

PROTAC Bcl-xL ligand-1	Ligands for Target Protein for PROTAC Bcl-2 Family	Cancer
PROTAC Bcl-xL ligand-1 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs .

HY-132942A

PROTAC BRD4 ligand-2 hydrochloride	Ligands for Target Protein for PROTAC	Cancer
PROTAC BRD4 ligand-2 hydrochloride is a ligand for target BRD4 protein for *PROTAC* CFT-2718.

HY-145484

PROTAC IRAK4 ligand-3	Ligands for Target Protein for PROTAC	Cancer
PROTAC IRAK4 ligand-3 is a ligand of PROTAC KT-474 (HY-145483) that can be used in cancer research .

HY-168611

PROTAC IRAK4 ligand-4	Ligands for Target Protein for PROTAC IRAK	Cancer
PROTAC IRAK4 ligand-4 is a **Ligand for Target Protein for PROTAC** with antitumor activity. PROTAC IRAK4 ligand-4 can be used to synthesize PROTAC IRAK4 degrader-12 (HY-168586) .

HY-168638

PROTAC SOS1 ligand 1	Ligands for Target Protein for PROTAC	Cancer
PROTAC SOS1 ligand 1, a BI-3406 (HY-125817) analog, is a ligand for target SOS1 protein for PROTACT SIAIS562055 (HY-168637) .

HY-162876

PROTAC BRD4 ligand-3	Ligands for Target Protein for PROTAC	Cancer
PROTAC BRD4 ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC BRD4 ligand-3 can be used for synthesis PROTAC BRD4 Degrader-27 (HY-162875) .

HY-168311

PROTAC IRAK4 ligand-5	Ligands for Target Protein for PROTAC	Cancer
PROTAC IRAK4 ligand-5 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC IRAK4 ligand-5 can be utilized for the synthesis of KT-413 (HY-153368) .

HY-158152

PROTAC CRBN ligand-2	Ligands for E3 Ligase	Cancer
PROTAC CRBN ligand-2 (12) is a Biguanide-PROTAC derivative, with an EC₅₀ of 0.15 mM in KP4 cells. PROTAC CRBN ligand-2 (12) demonstrates the ability to alter levels of mitochondrial proteins, notably complexes I and IV .

HY-132942

PROTAC BRD4 ligand-2	Ligands for Target Protein for PROTAC	Cancer
PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for *PROTAC* CFT-2718.

HY-159164

PROTAC CRBN ligand-3	Ligands for Target Protein for PROTAC	Cancer
PROTAC CRBN ligand-3 is a target protein ligand of RGB110 (HY-159087).

HY-129967

PROTAC IRAK4 ligand-1	Ligands for Target Protein for PROTAC	Cancer
PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4 (IRAK4). PROTAC IRAK4 ligand-1 can be used in the synthesis of PROTAC IRAK4 degrader-1 (HY-129966) .

HY-139660

PROTAC PTK6 ligand-1	Ligands for Target Protein for PROTAC	Cancer
PROTAC PTK6 ligand-1 is an intermediate for BTK kinase inhibitor preparation . PROTAC PTK6 ligand-1 can be used in the synthesis of ARD-61 (HY-139659) .

HY-141486

*(Rac)-PROTAC* PARP/EGFR ligand 1**	Target Protein Ligand-Linker Conjugates	Cancer
(Rac)-PROTAC PARP/EGFR ligand 1 incorporates a ligand for PARP and EGFR , and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). (Rac)-PROTAC PARP/EGFR ligand 1 can be used in the synthesis of DP-C-4, which is CRBN-based dual PROTAC for simultaneous degradation of EGFR and PARP .

HY-126351

PROTAC ERRα ligand 2	Estrogen Receptor/ERR	Cancer
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC₅₀ of 5.67 nM. PROTAC ERRα ligand 2 (IC₅₀=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC₅₀=61.3 nM) .

HY-141486A

PROTAC PARP/EGFR ligand 1	PARP EGFR Ligands for Target Protein for PROTAC	Others
PROTAC PARP/EGFR ligand 1 is an active compound that can be used for the synthesis of dual PARP EGFR degraders by proteolytic targeting chimera *(PROTAC)* technology .

HY-129939

PROTAC BRD4 ligand-1	Epigenetic Reader Domain Ligands for Target Protein for PROTAC	Cancer
PROTAC BRD4 ligand-1 is a potent BET inhibitor and a ligand for target BRD4 protein for PROTACT GNE-987 (HY-129937A) .

HY-115729A

*(R)-PROTAC* CDK9 ligand-1**	Ligands for Target Protein for PROTAC CDK	Cancer
(R)-PROTAC CDK9 ligand-1 (Compound 19.4) is a CDK9-targeting degrader that can be used to synthesize PROTAC with antitumor activity .

HY-44012B

*SMARCA-BD ligand* 1 for PROTAC hydrochloride** 1 Publications Verification	Ligands for Target Protein for PROTAC	Cancer
SMARCA-BD ligand 1 hydrochloride for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC .

HY-44012

SMARCA-BD ligand 1 for PROTAC 1 Publications Verification	Ligands for Target Protein for PROTAC	Cancer
SMARCA-BD ligand 1 for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC .

HY-44012A

*SMARCA-BD ligand* 1 for PROTAC dihydrochloride** 1 Publications Verification	Ligands for Target Protein for PROTAC	Cancer
SMARCA-BD ligand 1 for PROTAC dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC .

HY-130297

PROTAC BCR-ABL1 ligand 1	Bcr-Abl	Cancer
PROTAC BCR-ABL1 ligand 1, compound GMB-475, is the ligand of PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of BCR-ABL1 .

HY-U00425

PROTAC ERRα ligand 1	Estrogen Receptor/ERR	Cancer
PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist with IC₅₀s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively .

HY-75578

dTAG Targeting Ligand 1	Polo-like Kinase (PLK) Ligands for Target Protein for PROTAC	Cancer
dTAG Targeting Ligand 1 (SUBSTITUTE SHEET 245) is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). dTAG Targeting Ligand 1 can be used for synthesis PROTACs .

HY-130296

Palbociclib-propargyl PROTAC CDK6 ligand 1	Ligands for Target Protein for PROTAC	Cancer
Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC₅₀ of 2.1 nM for CDK6 . Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W342590

CRBN ligand-9	Ligands for E3 Ligase	Cancer
CRBN ligand-9 (Compound 4d) is a CRBN ligand (K_i: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs .

HY-163216

PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc is a *conjugate of E3 ligase ligand* and linker*, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand* that recruits VHL proteins. PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

HY-163217

PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc is a *conjugate of E3 ligase ligand* and linker*, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand* that recruits VHL proteins. PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

HY-163215

*(S)-PROTAC* PTK6 ligand-O-4,4-dimethylpiperidine-Boc**	E3 Ligase Ligand-Linker Conjugates	Cancer
(S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc is a *conjugate of E3 ligase ligand* and linker*, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand* that recruits VHL proteins. (S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

HY-163228

PROTAC PTK6 ligand-O-C2-O-piperidine-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
PROTAC PTK6 ligand-O-C2-O-piperidine-Boc is a *conjugate of E3 ligase ligand* and linker*, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand* that recruits VHL proteins. PROTAC PTK6 ligand-O-C2-O-piperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

HY-168449

BAZ2A/B ligand 1	Ligands for Target Protein for PROTAC	Cancer
BAZ2A/B ligand 1 (compound 1) is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). BAZ2A/B ligand 1 can be used for synthesis dBAZ2 (HY-168448) .

HY-44824

SMARCA2 ligand-13	Epigenetic Reader Domain Ligands for Target Protein for PROTAC	Cancer
SMARCA2 ligand-13 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMARCA2 ligand-13 can be used for synthesis PROTACs .

HY-163224

*(S)-PROTAC* PTK6 ligand-O-C2-O-piperidine-Boc**	E3 Ligase Ligand-Linker Conjugates	Cancer
(S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc is a *conjugate of E3 ligase ligand* and linker*, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand* that recruits VHL proteins. (S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

HY-161830

CDK7 ligand 2	Ligands for Target Protein for PROTAC	Cancer
CDK7 ligand 2 (Compound A6) is a CDK7 ligand. CDK7 ligand 2 can be used in the synthesis of *PROTACs* .

HY-168226

E3 ligase Ligand 34	Ligands for E3 Ligase	Others
E3 ligase Ligand 34 is the E3 ligase ligand part of PROTAC SMARCA2/4-degrader-35 (HY-168225) and can be utilized in the synthesis of PROTACs .

HY-W190956

(S,R,S)-AHPC-PEG4-acid	Others	Cancer
(S,R,S)-AHPC-PEG4-acid is a synthetic PROTAC ligand that binds the E3 ligase ligand to the PEG4 arm, thereby enhancing PROTAC drug research and discovery .

HY-168275

TRIB2 ligand-1	Ligands for Target Protein for PROTAC	Cancer
TRIB2 ligand-1 is a ligand of TRIB2 (Ligands for Target Protein for PROTACs). TRIB2 ligand-1 can be used for synthesis PROTAC TRIB2 degrader-1 (HY-168274) .

HY-169487

SMARCA2 ligand-12	Epigenetic Reader Domain Ligands for Target Protein for PROTAC	Cancer
SMARCA2 ligand-12 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). SMARCA2 ligand-12 can be used for synthesis PROTAC SMARCA2 degrader-25 (HY-169276) .

HY-168191

TBL1X ligand 1	Ligands for Target Protein for PROTAC	Cancer
TBL1X ligand 1 is a PROTAC target protein ligand and is used to synthesize PROTAC TBL1X degrader-1 (HY-168190) .

HY-163218

PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid	E3 Ligase Ligand-Linker Conjugates	Cancer
PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

HY-W761299

PD 4'-oxyacetic acid	Ligands for E3 Ligase	Neurological Disease
PD 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC Degrader development .

HY-168702

FLT3 ligand-2	Ligands for Target Protein for PROTAC	Cancer
FLT3 ligand-2 is a **Ligand for Target Protein for PROTAC*. FLT3 ligand-2 can be used to synthesize PROTAC* FLT-3 degrader 1 (HY-114323) .

HY-150859

HDAC ligand-1	HDAC Ligands for Target Protein for PROTAC	Cancer
HDAC ligand-1 is a HDAC ligand that can be used to synthesize PROTAC HDAC degraders, such as compounds 21a and 21b in references .

HY-168299

AR ligand-30	Ligands for Target Protein for PROTAC	Cancer
AR ligand-30 is a target protein ligand for *PROTAC* Bavdegalutamide (HY-138641), which can be used in prostate cancer research .

HY-163214

*(S)-PROTAC* PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid**	E3 Ligase Ligand-Linker Conjugates	Cancer
(S)-PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

HY-168314

BTK ligand 11	Ligands for Target Protein for PROTAC	Cancer
BTK ligand 11 is a *PROTAC* target protein ligand that can be used to synthesize BCPyr (HY-142621) .

HY-168691

PTPN2 ligand 1	Ligands for Target Protein for PROTAC	Cancer
PTPN2 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). PTPN2 ligand 1 can be used to synthesize PVD-06 (HY-149760) .

HY-168283

HPK1 ligand 2	Ligands for Target Protein for PROTAC	Cancer
HPK1 ligand 2 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). HPK1 ligand 2 can be used for synthesis DD205-291 (HY-168282) .

HY-168685

c-Myc ligand 1	c-Myc Ligands for Target Protein for PROTAC	Cancer
c-Myc ligand 1, a c-Myc inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). c-Myc ligand 1 can be used for synthesis PROTAC c-Myc inhibitor 7 (HY-148837) .

HY-168671

pan-KRAS ligand 1	Ligands for Target Protein for PROTAC Ras	Cancer
pan-KRAS ligand 1 is a **Ligand for Target Protein for PROTAC*. pan-KRAS ligand* 1 can be used for synthesis PROTAC pan-KRAS degrader 4 (HY-168669) .

Cat. No.	Product Name

HY-L129

Target Protein Ligand Library

56 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 56 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

HY-L128

E3 Ligase Ligand Library

74 compounds

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 74 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

HY-L151

PROTAC Library

356 compounds

PROTACs (Proteolysis-targeting chimeras) is a class of molecules that utilize ubiquitin-proteasome system (UPS) to ubiquitinate and degrade target proteins. The PROTACs molecule consists of two ligands joined by a linker. The one-to-one interaction between PROTACs and target proteins determines the high efficiency of PROTACs, making it a potential molecule for targeted protein degradation (TPD) therapy.

MCE supplies a unique collection of 356 PROTACs that effectively degrade target proteins with more powerful screening capability. MCE PROTAC Library is a useful tool for signal pathway research, protein degradation therapy research, drug discovery and drug repurposing, etc.

HY-L918

Molecular Glue-like Compound Library

800 compounds

Targeted Protein Degradation (TPD) is a novel and promising approach to drug development. It shows great potential for targeting proteins traditionally considered "undruggable" due to the lack of enzymatic function and absence of binding sites by tagging them for degradation or recruiting natural degradation mechanisms.

Molecular glues are a type of small-molecule degraders that primarily induce novel interactions between E3 ubiquitin ligases and target proteins, forming ternary complexes that lead to protein ubiquitination and subsequent proteasomal degradation. Compared with PROTACs, molecular glues generally have lower molecular weights, higher cell permeability, and better drug-like properties. Additionally, the design of molecular glues is relatively simple, without the requirements for complex linkers and ligand optimization. As a result, molecular glues have gradually emerged as a promising therapeutic approach for various diseases.

Multiple types of molecular glues have been reported previously. Analysis of co-crystal complex structures reveals that CRBN-, VHL-, and DCAF-related molecular glues are more versatile. Therefore, MCE researchers select active molecules related to these targets as probes for artificial intelligence (AI) screening.Subsequently, molecular docking technology was used to verify whether the screened molecules retained the key pharmacophore features. Ultimately, we obtained 800 molecular glue analogs, and these compounds serve as powerful tools for the research of molecular glues.

Cat. No.	Product Name	Type

HY-D2336

PROTAC Aster-A degrader-1	Fluorescent Dyes/Probes
PROTAC Aster-A degrader-1 (compound NGF3) is a degrader of the sterol transport protein Aster-A. PROTAC Aster-A degrader-1 can be used as a fluorescence probe. (Red: Aster-A inhibitor, black: linker, Blue: E3 ligase ligand) .

Cat. No.	Product Name	Target	Research Area

HY-169235

DHHC3 degrader 1	Ligands for Target Protein for PROTAC	Cancer
DHHC3 degrader 1 is a PROTAC target protein ligand that is used to synthesize PCC16 chloride (HY-169232) .

HY-162946

Alkyne-P60	Ligands for Target Protein for PROTAC	Cancer
Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a **ligand for target protein for PROTAC** (HY-162943).

Cat. No.	Product Name	Chemical Structure

HY-126534S

Abemaciclib metabolite M18-d8
Abemaciclib metabolite M18-d₈ is the deuterium labeled Abemaciclib metabolite M18. Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1][2].

HY-13001S

Quizartinib-d8

Quizartinib-d₈ (AC220-d₈) is deuterium labeled Quizartinib. Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a K_d of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC₅₀s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis .

Cat. No.	Product Name		Classification

HY-130296

Palbociclib-propargyl PROTAC CDK6 ligand 1		Alkynes
Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC₅₀ of 2.1 nM for CDK6 . Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-126456

(S,R,S)-AHPC-propargyl 2 Publications Verification VH032-propargyl; VHL ligand 7		PROTAC Synthesis Alkynes
(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs . (S,R,S)-AHPC-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159164

PROTAC CRBN ligand-3		Azide
PROTAC CRBN ligand-3 is a target protein ligand of RGB110 (HY-159087).

HY-139343

Pomalidomide 4'-alkylC2-azide		Azide
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .

HY-139341

Pomalidomide 4'-alkylC3-azide		Azide
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .

HY-147192

(S,R,S)-AHPC-O-PEG1-propargyl		Alkynes
(S,R,S)-AHPC-O-PEG1-propargyl (Compound 10b) is an E3 ligand for the synthesis of PROTAC . (S,R,S)-AHPC-O-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133189

Bis-propargyl-PEG9		PROTAC Synthesis Alkynes
Bis-propargyl-PEG9 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands . Bis-propargyl-PEG9 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159544

SMARCA2 ligand-7		Azide
SMARCA2 ligand-7 is a ligand for target protein for pROTAC.

HY-159542

SMARCA2 ligand-6		Azide
SMARCA2 ligand-6 is a ligand for target protein for pROTAC.

HY-159545

SMARCA2/4-ligand-2		Azide
SMARCA2/4-ligand-2 is a ligand for target protein for pROTAC.

HY-159615

Cbl-b-IN-21		Azide
Cbl-b-IN-21 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Cbl-b-IN-21 can be used for synthesis PROTAC Cbl-b-IN-1 (HY-159608) .

HY-151792

Pomalidomid-C6-PEG3-butyl-N3		Azide PROTAC Synthesis
Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. Pomalidomid-C6-PEG3-butyl-N3 also is a *crosslinker-E3 ligase ligand* conjugate*, which be used in click reactive protein degrader building block for PROTAC* research. Pomalidomid-C6-PEG3-butyl-N3 also can be used in the template for synthesis of targeted protein degrader . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-172360

HDAC6 ligand-3		Alkynes
HDAC6 ligand-3 is a ligand for HDAC6 that can be used as target protein ligand for synthesis of PROTAC HDAC6 degrader 4 (HY-172359) .

HY-163926

SMARCA2/4-IN-2		Azide
SMARCA2/4-IN-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-IN-2 can be used for synthesis PROTAC SMARCA2/4-degrader-5 (HY-159456) .

HY-161132

Lenalidomide 4'-alkyl-C5-azide		Azide
Lenalidomide 4'-alkyl-C5-azide is a functionalized cerebellar ligand for PROTAC development that contains an E3 ligand and an alkyl LC5 ligand with terminal azides that can be coupled to a target protein ligand .

HY-401613

E3 ligase Ligand 43		Azide
E3 ligase Ligand 43 serves as the E3 ubiquitin ligase ligand for ACBI3 (HY-157228). E3 ligase Ligand 43 can be utilized for the synthesis of PROTACs .

HY-107442

PROTAC BRD4-binding moiety 1		Alkynes
PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136) . PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159608

PROTAC Cbl-b-IN-1		Azide
PROTAC Cbl-b-IN-1 (compound 64) is a PROTAC targeting Cbl-b. PROTAC Cbl-b-IN-1 is composed of PROTAC target protein ligand Cbl-b-IN-21 (HY-159615), PROTAC Linker Cbz-Pip-2C-Pip-C-Pip (HY-159617) and E3 ubiquitin ligase ligand (3S) Lenalidomide-5-Br (HY-W797329), where the E3 ubiquitin ligase ligand + Linker conjugate is (3S) Lenalidomide-5-Pip-C-Pip-2C-Pip (HY-159618) ^{[1] ^.}

HY-69220

7-Octynoic acid		PROTAC Synthesis Alkynes
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins . 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-163167

VH 032 amide-alkylC5-azide		Azide
VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .

HY-130197

Lipoamido-PEG4-azide		PROTAC Synthesis Azide
Lipoamido-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Lipoamido-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159801

E3 Ligase Ligand-linker Conjugate 122		Azide
E3 Ligase Ligand-linker Conjugate 122 (Compound 2c) is a conjugation of the E3 ligase ligand and the linker, and can be used for synthesis of PROTAC degrader NR-11c (HY-159798) .

HY-161134

Lenalidomide 4'-PEG2-azide		Azide
Lenalidomide 4'-PEG2-azide is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG2-azide can be connected to the ligand for protein by a linker to form PROTAC .

HY-159449

PROTAC SMARCA2 degrader-5		Azide
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159457

PROTAC SMARCA2/4-degrader-6		Azide
PROTAC SMARCA2/4-degrader-6 (compound I-438) is a SMARCA2/4 degrader. PROTAC SMARCA2/4-degrader-6 has the potential for the research of cancer. (Pink: SMARCA2/4 ligand, (HY-159545); Black: linker (HY-W006635); Blue: VHL ligand (HY-112078)) .

HY-159451

PROTAC SMARCA2 degrader-7		Azide
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2 and SMARCA4 in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-108374

4-Azidobutylamine		Azide PROTAC Synthesis
4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins . 4-Azidobutylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-139339

Pomalidomide 4'-alkylC6-azide		Azide
Pomalidomide 4'-alkylC6-azide is the Pomalidomide (HY-123324)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC6-azide can be connected to the ligand for protein by a linker to form PROTAC .

HY-139333

Pomalidomide 4'-PEG5-azide		Azide
Pomalidomide 4'-PEG5-azide is the Pomalidomide (HY-123324)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 4'-PEG5-azide can be connected to the ligand for protein by a linker to form PROTAC .

HY-159461

PROTAC SMARCA2/4-degrader-9		Azide
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-157514

Thalidomide 4'-ether-PEG1-azide		Azide
Thalidomide 4'-ether-PEG1-azide is the Thalidomide (HY-14658)-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4'-ether-PEG1-azide can be connected to the ligand for protein by a linker to form PROTACs .

HY-159456

PROTAC SMARCA2/4-degrader-5		Azide
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159455

PROTAC SMARCA2/4-degrader-4		Azide
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2 in MV411 and in A549 with DC₅₀ <100 nM, degrades SMARCA4 in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159460

PROTAC SMARCA2/4-degrader-8		Azide
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades SMARCA2 with DC₅₀ <100 nM in A549 and in MV411, degrades SMARCA4 with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-126457

Thalidomide-propargyl		Alkynes
Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs . Thalidomide-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-159087

RGB110		Azide
RGB110 (Compound 10d) is a PROTAC inhibitor for D-dopachrome tautomerase with an IC₅₀ of 5.9 μM. RGB110 causes no degradation of D-DT. (Pink: ligand for target protein (HY-159164); Black: linker (HY-W125017); Blue: ligand for E3 ligase CRBN (HY-10984))

HY-W674324

Thalidomide-5-NH-C-alkyne		Alkynes
Thalidomide-5-NH-C-alkyne contains an E3 ligase ligand with a terminal alkyne. Thalidomide-5-NH-C-alkyne is ready for conjugation to target proteins for PROTAC.

HY-172361

Thalidomide-F-NH-C6-adize		Azide
Thalidomide-F-NH-C6-adize is the conjugate of an E3 ligase (Cereblon) ligand and a linker, and can be used for synthesis of PROTAC HDAC6 degrader 4 (HY-172359) .

HY-159799

p38α inhibitor 5		Alkynes
p38α inhibitor 5 (compound 1) is a PROTAC-type target protein ligand targeting p38 and can be used to synthesize NR-11c (HY-159798) .

HY-126458

Thalidomide-O-PEG2-propargyl E3 ligase ligand-Linker Conjugates 32		Alkynes
Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized *E3 ligase ligand-linker conjugate* that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Thalidomide-O-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-163647

Lenalidomide-COCH-PEG2-azido		Azide
Lenalidomide-COCH-PEG2-azido is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based cereblon ligand and a linker. Lenalidomide-COCH-PEG2-azido can be used in the synthesis of PROTAC AKR1C3 degrader-1 (HY-163609) .

HY-140055

Thalidomide-PEG4-Propargyl		Alkynes
Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology . Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W615166

Thalidomide-NH-C2-alkyne		Alkynes
Thalidomide-NH-C2-alkyne contains an E3 ligase ligand with an alkyl linker, and a terminal alkyne. Thalidomide-NH-C2-alkyne is ready for conjugation to target proteins for PROTAC R&D.

HY-160077

Pomalidomide-CO-C5-azide		Azide
Pomalidomide-CO-C5-azide (Compound PA) is a ligand for E3 ligase bearing a bioorthogonal group azide. Pomalidomide-CO-C5-azide can be used to synthesize *PROTACs* with anticancer activity .

HY-159472

SMARCA2/4-ligand-1		Azide
2-(6-Amino-5-(1-(piperidin-4-ylmethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)phenol is a Ligand for target protein for pROTAC.

HY-159165

Pomalidomide-cyclopentane-amide-Alkyne		Alkynes
Pomalidomide-cyclopentane-amide-Alkyne is an *E3 ligase ligand-linker conjugate* that incorporates the Pomalidomide (HY-10984) and the linker cyclopentane-amide-Alkyne. Pomalidomide-cyclopentane-amide-Alkyne is used to form PROTACs, such as RGB110 (HY-159087) .

HY-139332

Pomalidomide 4'-PEG6-azide		Azide
Pomalidomide 4'-PEG6-azide (compound 33e) is the *E3 ligase ligand-linker conjugate* used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs .

HY-128767

VH032-PEG3-acetylene		Alkynes
VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in *PROTAC* technology . VH032-PEG3-acetylene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148556

Thalidomide-O-C6-azide		Azide
Thalidomide-O-C6-azide is a synthesized *E3 ligase ligand-linker conjugate* (*E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)) based cereblon ligand* and a linker used in PROTAC technology . Thalidomide-O-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-141015

Pomalidomide-PEG4-azide		Azide
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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