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Src homology 2 domain-containing phosphatase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Epigenetic Reader Domain (5) Phosphatase (285) PTEN (4) SHP2 (18) Src (138) 5-HT Receptor (3) Acyltransferase (1) Adrenergic Receptor (4) AIM2 (1) Akt (13) Aldose Reductase (1) Amyloid-β (2) Androgen Receptor (3) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (31) Apoptosis (102) Aryl Hydrocarbon Receptor (1) ATM/ATR (3) Aurora Kinase (3) Autophagy (38) Bacterial (25) Bcl-2 Family (1) Bcr-Abl (29) BCRP (1) Beta-lactamase (6) Beta-secretase (1) Biochemical Assay Reagents (23) Btk (4) c-Fms (1) c-Kit (9) c-Met/HGFR (3) c-Myc (1) Calcineurin (1) CaMK (3) Carbamoyl Phosphate Synthetase (CPS) (1) Carbonic Anhydrase (1) Carboxylesterase (1) Caspase (1) Cathepsin (1) CD276/B7-H3 (1) CDK (3) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (6) Complement System (4) COX (5) CRISPR/Cas9 (4) Cyclophilin (3) Cytochrome P450 (4) Deubiquitinase (1) DNA-PK (2) DNA/RNA Synthesis (6) Dopamine β-hydroxylase (1) Drug Derivative (1) Drug Isomer (1) Drug Metabolite (4) E1/E2/E3 Enzyme (1) EBV (1) EGFR (17) Endogenous Metabolite (30) Enterovirus (1) Ephrin Receptor (1) Epoxide Hydrolase (1) ERK (9) Estrogen Receptor/ERR (2) FAAH (1) FAK (9) FGFR (15) FKBP (5) FLT3 (4) Fluorescent Dye (13) Formyl Peptide Receptor (FPR) (1) Fungal (10) FXR (1) G-quadruplex (3) Gap Junction Protein (2) GCGR (1) Glutaminase (1) Glutathione Peroxidase (1) Glycosidase (4) HDAC (10) Hedgehog (1) Histone Demethylase (4) Histone Methyltransferase (8) HIV (6) HIV Protease (2) HSP (2) HSV (1) IAP (1) IGF-1R (2) iGluR (3) IKK (1) Influenza Virus (1) Insulin Receptor (1) Integrin (2) Interleukin Related (2) Isotope-Labeled Compounds (11) JAK (8) JNK (4) Lactate Dehydrogenase (1) LDLR (1) Leukotriene Receptor (1) LIM Kinase (LIMK) (1) Liposome (1) Lipoxygenase (1) LXR (1) MAGL (7) MAP3K (3) MAP4K (1) MAPKAPK2 (MK2) (2) Mas-related G-protein-coupled Receptor (MRGPR) (1) MDM-2/p53 (1) MEK (1) mGluR (1) MicroRNA (1) Microtubule/Tubulin (4) Mineralocorticoid Receptor (1) Mitochondrial Metabolism (1) MMP (3) MNK (1) Molecular Glues (3) Monoamine Oxidase (2) mTOR (3) Mucin (1) Necroptosis (1) Neuropeptide Y Receptor (1) NF-κB (6) NO Synthase (2) NOD-like Receptor (NLR) (5) Notch (1) Nuclear Factor of activated T Cells (NFAT) (1) P2Y Receptor (1) p38 MAPK (10) PAK (1) Paraptosis (2) Parasite (21) PD-1/PD-L1 (1) PDGFR (17) PDI (1) PERK (1) Phosphodiesterase (PDE) (3) Phospholipase (3) PI3K (7) PKA (4) PKC (7) PKD (1) Polo-like Kinase (PLK) (1) PPAR (2) Progesterone Receptor (2) Prostaglandin Receptor (2) PROTACs (4) Protease Activated Receptor (PAR) (1) Pyk2 (1) Raf (9) Ras (3) Reactive Oxygen Species (6) RET (3) Reverse Transcriptase (3) Ribosomal S6 Kinase (RSK) (3) ROR (1) SARS-CoV (3) SDCBP (1) Secretin Receptor (1) Ser/Thr Protease (2) Sirtuin (3) Small Interfering RNA (siRNA) (3) Somatostatin Receptor (1) STAT (12) Syk (4) Tau Protein (1) TGF-β Receptor (1) Thyroid Hormone Receptor (1) Tie (2) TMV (1) Toll-like Receptor (TLR) (2) Topoisomerase (5) TRP Channel (1) Urea Transporter (1) VEGFR (26) Virus Protease (1) Wnt (1) α-synuclein (1)
By Research Areas:	Cancer (378) Cardiovascular Disease (24) Endocrinology (22) Infection (61) Inflammation/Immunology (92) Metabolic Disease (98) Neurological Disease (57)
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Oligonucleotides:	Pre-designed siRNA Sets (3) mRNA (1) Phospholipids (1) Antisense Oligonucleotides (2) siRNAs (3)

702

Inhibitors & Agonists

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366

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Targets Recommended: Src Phosphatase SHP2 Discoidin Domain Receptor Epigenetic Reader Domain PIKfyve PTEN BCL6 VISTA WDR5 Tim3 VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2521

Tetramethylcurcumin FLLL31	STAT Apoptosis	Inflammation/Immunology Cancer
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects ^[2].

HY-P3279

EPQpYEEIPIYL 1 Publications Verification	Src	Cancer
EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains ^[2].

HY-18685

CPDA	Phosphatase	Metabolic Disease
CPDA is a novel potent SH2 domain-containing inositol phosphatase 2 (SHIP2) inhibitor.

HY-19776

3α-Aminocholestane 4 Publications Verification	Phosphatase	Cancer
3α-Aminocholestane is a selective *SH2 domain-containing* inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC₅₀** of ~2.5 μM.

HY-19820A

NSC45586 sodium	Akt Ser/Thr Protease	Neurological Disease Cancer
NSC45586 sodium is an inhibitor of *pleckstrin homology* domain and leucine-rich repeat protein phosphatase (PHLPP)*. NSC45586 sodium targets the PP2C phosphatase* domain in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons .

HY-N12613

Sydowimide A	Phosphatase	Inflammation/Immunology
Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC₅₀ values of 1.5, 2.4 and 18.83 μM, respectively .

HY-163469

SRC-3-IN-2	Src	Cancer
SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor. SRC-3-IN-2 has antitumor activity .

HY-157507

JC-010a	SHP2 Apoptosis	Cancer
JC-010a is a selective *SHP2* allosteric inhibitor. JC-010a inhibits cancer cells proliferation. JC-010a can be used for the research of cancer .

HY-168187

Src Inhibitor 3	Src	Cancer
Src Inhibitor 3 (Compound 7d) is a *Src* inhibitor with an IC₅₀ of 285 nM. Src Inhibitor 3 inhibits HepG2 cells proliferative with an IC₅₀ of 1.55 μM .

HY-19820

NSC45586	Akt Ser/Thr Protease	Neurological Disease Cancer
NSC45586 is an inhibitor of *pleckstrin homology* domain and leucine-rich repeat protein phosphatase (PHLPP)*. NSC45586 targets the PP2C phosphatase* domain in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons .

HY-N3561

Cedrelone	Apoptosis	Cancer
Cedrelone, a limonoid, is a *Phenazine biosynthesis-like domain-containing* protein (PBLD) activator. Cedrelone induces cancer cell apoptosis**, and possess antitumor effects .

HY-156970

Phosphatase Binder-1	Others	Cancer
Phosphatase Binder-1 (comppund i-196) provides bifunctional compounds that efficiently dephosphorylate certain phospho-activated target proteins. Phosphatase Binder-1 plays an important role in cancer .

HY-E70382

Shrimp Alkaline Phosphatase	Phosphatase Biochemical Assay Reagents	Others
Shrimp Alkaline Phosphatase (SAP), a nucleotide phosphatase, can catalyze the removal of 5′ phosphates from nucleic acid templates. Shrimp Alkaline Phosphatase is readily inactivated in the absence of chelators and is widely used phosphatases in molecular cloning .

HY-D2204

SHP1-IN-1	Phosphatase Fluorescent Dye	Cancer
SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe ³⁺ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM) .

HY-P2818

*Alkaline phosphatase, Bovine intestine* 1 Publications Verification Apase	Endogenous Metabolite	Metabolic Disease Cancer
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation ^[2].

HY-108488

*KB SRC* 4**	Src	Cancer
KB SRC 4 is a potent, and highly selective *c-Src* inhibitor, with a K_i of 44 nM and a K_d of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity.

HY-153992

STAT6-IN-3	STAT	Inflammation/Immunology
STAT6-IN-3 (Compound 18a) is a STAT6 inhibitor (IC₅₀= 44 nM). STAT6-IN-3 targets the Src Homology 2 (SH2) domain of STAT6. STAT6-IN-3 can be used for research of inflammation such as asthma .

HY-W017132

2,4-PDCA	Histone Demethylase	Cancer
2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including *JmjC domain-containing* family of histone demethylases (JHDMs)**. 2,4-PDCA is a target chemical in the field of bio-based plastics ^[2] .

HY-P0200

RR-SRC	Src	Inflammation/Immunology
RR-SRC is a substrate for src-tyrosine-specific protein kinase .

HY-101053

Src Inhibitor 1 10+ Cited Publications Src Kinase Inhibitor 1; Src-l1	Src	Cancer
Src Inhibitor 1 is a potent, ATP-competitive and selective dual site *Src* tyrosine kinase inhibitor with IC₅₀ values of 44 nM for Src and 88nM for Lck.

HY-163468

SRC-3-IN-1	Src	Cancer
SRC-3-IN-1 (compound SI-10) is a steroid receptor coactivator 3 (SRC-3) inhibitor (IC₅₀=3.3 μM). SRC-3-IN-1 has good water solubility, oral bioavailability, and improved selectivity profile. SRC-3-IN-1 can be used in prostate cancer research .

HY-158774

TG2-179-1	Apoptosis	Cancer
TG2-179-1 is a potent BAP1 inhibitor. TG2-179-1 inhibits the domain-containing deubiquitinase (DUB) activity of BAP1 by covalently binding to its active site. TG2-179-1 exerts cytotoxic activity, leading to defective replication and increased apoptosis. TG2-179-1 has the potential for colon cancer research .

HY-164607

YL-5092	DNA/RNA Synthesis Others	Cancer
YL-5092 is an inhibitor for YT521-B homology (YTH) domain-containing protein 1 (YTHDC1). YL-5092 inhibits acute myeloid leukemia cell with IC₅₀ of 0.28-2.87 μM. YL-5092 exhibits antitumor efficacy in MOLM-13 or U937 xenograft mice .

HY-P5458

SRC-1 (686-700)	Mineralocorticoid Receptor	Others
SRC-1 (686-700) is a biological active peptide. (This peptide is amino acids 686 to 700 fragment containing the second LXXLL motif, derived from NR box II of steroid receptor coactivator (SRC1). Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription.)

HY-P3743

*p60c-src* Substrate**	Src Others	Others
p60c-src Substrate is an efficient and specific substrate for *p60c-src* protein tyrosine kinase (PTK). p60c-src Substrate can be used to synthesize chimeric branched peptides ^[2].

HY-16905

*T338C Src-IN-1*	Src	Cancer
T338C Src-IN-1 is a potent mutant-Src T338C inhibitor; exhibited the most potent inhibition of T338C(IC50=111 nM) relative to WT c-Src (10-fold increase).

HY-P3773

*p60c-src* substrate II**	Src	Cancer
p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase *pp60c-src* .

HY-156914

*IGF-1R/SRC-IN-1*	IGF-1R Src	Cancer
IGF-1R/SRC-IN-1 (Compound 3b) is an inhibitor for IGF-1R (IC₅₀ is 63 μM) and *SRC* .

HY-E70373

λ Protein phosphatase	Biochemical Assay Reagents	Others
λ Protein phosphatase is a serine/threonine phosphatase encoded by bacteriophage Lambda. λ Protein phosphatase is activated with requirement for divalent cations, such as Mn ²⁺. λ Protein phosphatase is able to dephosphorylate casein, adenovirus E1A protein, and the α subunit of phosphorylase kinase

HY-E70360

*Acid Phosphatase* (ACP), Sweet Potato** Non-prostatic acid phosphatase, ACP, Orthophosphoric-monoester phosphohydrolase acid optimum, Acid phosphatase, AcPase, Apase	Others	Others
Acid Phosphatase (ACP), Sweet Potato (Non-prostatic acid phosphatase, ACP, Orthophosphoric-monoester phosphohydrolase acid optimum, Acid Phosphatase, AcPase, Apase) is a biological material or organic compound that can be used in life science research ^[2].

HY-149492

Phosphatase-IN-1	Phosphatase Fungal	Infection
Phosphatase-IN-1 (compound II-8), a propranolol (HY-B0573B) derivative, is a *phosphatidate phosphatase* (Pah)** inhibitor. Phosphatase-IN-1 can binds to MoPah1, with an affinity constant of 19.8 μM. Phosphatase-IN-1 inhibits growth of plant pathogens and shows anti-fungal ability. Phosphatase-IN-1 is not toxic to rice seedlings and wheat heads .

HY-P3771

*p60c-src* substrate II, phosphorylated**	Src	Others
p60c-src substrate II, phosphorylated is a pentapeptide. p60c-src substrate II, phosphorylated is a p60c-src substrate II phosphorylated polypeptide. Protein phosphorylation is an important post-translationmodification of protein that is indispensible in biological regulations .

HY-RS13749

SRC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SRC Human Pre-designed siRNA Set A contains three designed siRNAs for SRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SRC Human Pre-designed siRNA Set A SRC Human Pre-designed siRNA Set A

HY-RS13750

Src Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Src Mouse Pre-designed siRNA Set A contains three designed siRNAs for Src gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Src Mouse Pre-designed siRNA Set A Src Mouse Pre-designed siRNA Set A

HY-RS13751

Src Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Src Rat Pre-designed siRNA Set A contains three designed siRNAs for Src gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Src Rat Pre-designed siRNA Set A Src Rat Pre-designed siRNA Set A

HY-12299

WH-4-023 4 Publications Verification Dual LCK/Src inhibitor	Src	Cancer
WH-4-023 is a potent and selective dual *Lck/Src* inhibitor with IC₅₀ of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.

HY-119254

BAY-850 4 Publications Verification	Epigenetic Reader Domain	Metabolic Disease
BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 *(ATAD2)* inhibitor, with an IC₅₀ of 166 nM.

HY-W040256

*Acid phosphatase, wheat* ACP	Endogenous Metabolite	Metabolic Disease Cancer
Acid phosphatase, wheat (ACP) is an enzyme that removes phosphate from other molecules during digestion. Acid phosphatase catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid .

HY-P2548

*pp60 (v-SRC) Autophosphorylation Site, Phosphorylated*	EGFR	Others
pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is the phosphorylated peptide of an EGFR substrate. pp60 (v-SRC) Autophosphorylation Site, Phosphorylated can be used for the screening of EGFR Kinase inhibitors via phosphorylated-substrate quantification .

HY-D1676

Thymolphthalein monophosphate disodium hydrate	Phosphatase	Others
Thymolphthalein monophosphate disodium hydrate is a chromogenic substrate for the determination of acid phosphatase and alkaline phosphatase. Thymolphthalein is released during the reaction, increases the pH of the medium for easy detection, produces color and stops hydrolysis. Thymolphthalein monophosphate disodium hydrate can be used for the specific detection of prostatic phosphatase in serum ^[2].

HY-16906

*T338C Src-IN-2*	Src	Cancer
T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM; also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM.

HY-101628

VEGFR-2-IN-9 KDR-in-4	VEGFR	Cardiovascular Disease
VEGFR-2-IN-9 (KDR-in-4) is a potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor with an IC₅₀ of 7 nM.

HY-159656

PNPLA3 modifier 1	Others	Others
PNPLA3 modifier 1 (compound 10) is a Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifier, with a geometric mean EC₅₀ of 4.9 nM .

HY-P2818C

*Alkaline phosphatase, microorganism* Apase, microorganism	Endogenous Metabolite	Metabolic Disease
Alkaline phosphatase, microorganism is a membrane-bound glycoprotein. It can hydrolyze monophosphate esters at alkaline pH, releasing inorganic phosphate. Alkaline phosphatase, microorganism is also capable of dephosphorylating proteins, and the balance between protein phosphorylation and dephosphorylation plays a key role in regulating various cellular functions. Alkaline phosphatase, microorganism can regulate cell proliferation and differentiation .

HY-100824

PP2 Analog	Src	Cancer
PP2 Analog (compound 3) is a ATP-competitive *Src* family kinases inhibitor with the IC₅₀ values of 0.22, 0.15, 2.68, and 7 aganist of lck (64-509), src , kdr, and tie-2 .

HY-78144

4-Methylsalicylic acid	IAP	Inflammation/Immunology
4-Methylsalicylic acid is a salicylic acid. 4-Methylsalicylic acid derivative is a selective tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) inhibitor .

HY-129121

ML-226	MAGL	Neurological Disease
ML226 is a potent *α/β hydrolase domain-containing* protein 11 (ABHD11) inhibitor in vitro and in situ with IC₅₀**s of 15 and 0.68 nM, respectively .

HY-113817

SHIP1 activator 1	Phosphatase	Inflammation/Immunology
SHIP1 activator 1 is an SH3 domain-containing inositol 5-phosphatase regulator with SHIP1 activating activity. SHIP1 activator 1 retains its SHIA-1 activating ability by removing unnecessary functional groups. SHIP1 activator 1 is able to activate SHIP1 in vitro, inhibit Akt phosphorylation in MOLT-4 cells, and show dose-dependent activity in a mouse model of inflammation. SHIP1 activator 1 is an important chemical tool for evaluating the potential of SHIP1 activators as inhibitors of hematopoietic diseases involving abnormal PI3K cell signaling .

HY-P2818A

*Alkaline phosphatase, Escherichia coli* Apase, Escherichia coli	Endogenous Metabolite	Others
Alkaline phosphatase, Escherichia coli is a cytoplasm glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Escherichia coli can be used in molecular biology and enzyme-free analysis .

HY-W554649

p-Aminophenyl phosphate	Phosphatase	Others
p-Aminophenyl phosphate is an alkaline phosphatase substrate, and can be used for the electrochemical measurement of alkaline phosphatase activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2521

Tetramethylcurcumin FLLL31	Structural Classification other families Classification of Application Fields Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	STAT Apoptosis
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects ^[2].

HY-P2818

*Alkaline phosphatase, Bovine intestine* 1 Publications Verification Apase	Structural Classification Natural Products Animals Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Endogenous Metabolite
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation ^[2].

HY-W040256

*Acid phosphatase, wheat* ACP	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Acid phosphatase, wheat (ACP) is an enzyme that removes phosphate from other molecules during digestion. Acid phosphatase catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid .

HY-N0170

Indole-3-carbinol 5+ Cited Publications Indole-3-methanol	Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-108486

Herbimycin A	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Disease Research Fields	Bacterial Antibiotic
Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60 ^v-src and p210 ^BCR-ABL Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.

HY-N12613

Sydowimide A	Structural Classification Natural Products Microorganisms Marine natural products Source classification Marine microorganism	Phosphatase
Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC₅₀ values of 1.5, 2.4 and 18.83 μM, respectively .

HY-N3561

Cedrelone	Triterpenes Structural Classification Terpenoids Source classification Toona ciliata Roem. Plants Meliaceae	Apoptosis
Cedrelone, a limonoid, is a *Phenazine biosynthesis-like domain-containing* protein (PBLD) activator. Cedrelone induces cancer cell apoptosis**, and possess antitumor effects .

HY-P2040

Nodularin	Structural Classification other families Cyclopeptides Ketones, Aldehydes, Acids Marine natural products Source classification Plants	Phosphatase
Nodularin is a potent hepatotoxin, tumor promoter, and protein phosphatase inhibitor .

HY-N10186

Dibefurin	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Phosphatase Endogenous Metabolite
Dibefurin is a fungal metabolite that acts as an inhibitor of calcineurin phosphatase .

HY-110013

Terreic acid	Microorganisms Source classification	Btk Antibiotic
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC₅₀ of approximately 100 μM .

HY-N12776

Illudalic acid	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Phosphatase
Illudalic acid is a potent and selective Leukocyte antigen-related (LAR) phosphatase inhibitor with an IC₅₀ value of 1.30 µM. Illudalic acid inhibits LAR phosphatase through covalent ligation to the catalytic cysteine residue ^[2].

HY-N1549

Prunin Naringenin 7-0-glucoside	Structural Classification Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Enterovirus Phosphatase
Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 5.5 μM ^[2].

HY-N4317

Ethoxysanguinarine 1 Publications Verification	Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Macleaya cordata (Willd.) R. Br. Plants Disease Research Fields Papaveraceae Cancer	Apoptosis
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of *protein phosphatase* 2A** (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth .

HY-N4143

Cyanidin 3-arabinoside	other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Phosphatase
Cyanidin 3-arabinoside is a selective and reversible *protein tyrosine phosphatase* 1B (PTP1B) inhibitor, with an IC₅₀** of 8.91 μM. Cyanidin 3-arabinoside is potential for the research of type 2 diabetes .

HY-N1381

Periplocin 3 Publications Verification	Structural Classification Classification of Application Fields Source classification Asclepiadaceae Plants Periploca sepium Bunge Inflammation/Immunology Disease Research Fields Steroids	Apoptosis
Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase ^[2].

HY-N7599

Chrysophanol triglucoside	Quinones Monophenols Classification of Application Fields Cassia obtusifolia L. Anthraquinones Source classification Phenols Metabolic Disease Caesalpiniaceae Plants Disease Research Fields	Phosphatase Glycosidase
Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits *protein tyrosine phosphatases* 1B (PTP1B) and α-glucosidase with IC₅₀**s of 80.17 and 197.06 µM, respectively. Chrysophanol triglucoside has the potential for diabetes research .

HY-N12177

Cryptosporioptide A	Structural Classification Flavonoids Microorganisms Source classification Other Flavonoids	Phosphatase
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

HY-N2511

Trimyristin	Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite Disease Research Fields	Cholinesterase (ChE) Phosphatase Endogenous Metabolite
Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC₅₀s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-N12108

Forphenicine	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Phenols	Phosphatase
Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) ^[2].

HY-N1381R

Periplocin (Standard)	Structural Classification Source classification Asclepiadaceae Plants Periploca sepium Bunge Steroids	Apoptosis
Periplocin (Standard) is the analytical standard of Periplocin. This product is intended for research and analytical applications. Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase ^[2].

HY-N2511R

Trimyristin (Standard)	Structural Classification Natural Products Microorganisms Source classification Myristicaceae Plants Myristica fragrans Houtt. Endogenous metabolite	Cholinesterase (ChE) Phosphatase Endogenous Metabolite
Trimyristin (Standard) is the analytical standard of Trimyristin. This product is intended for research and analytical applications. Trimyristin, an active molluscicidal component of?Myristica fragrans?Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of?Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively .

HY-N10378

Rubrofusarin 6-O-β-D-glucopyranoside	Monophenols Classification of Application Fields Neurological Disease Cassia obtusifolia L. Source classification Phenols Metabolic Disease Caesalpiniaceae Plants Disease Research Fields	Phosphatase
Rubrofusarin 6-O-β-D-glucopyranoside, the glycoside of Rubrofusarin, is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with the IC₅₀ of 87.36 μM. Rubrofusarin 6-O-β-D-glucopyranoside can be used for the research of comorbid diabetes and depression .

HY-N6785

Okadaic acid 10+ Cited Publications	Structural Classification Animals Ketones, Aldehydes, Acids Marine natural products Source classification Other marine organisms	Phosphatase Apoptosis
Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC₅₀=0.1-0.3 nM), and inhibits PP1 (IC₅₀=15-50 nM), PP3 (IC₅₀=3.7-4 nM), PP4 (IC₅₀=0.1 nM), PP5 (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation ^[2].

HY-N6785R

Okadaic acid (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Marine natural products Source classification Other marine organisms	Phosphatase Apoptosis
Okadaic acid (Standard) is the analytical standard of Okadaic acid. This product is intended for research and analytical applications. Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC₅₀=0.1-0.3 nM), and inhibits PP1 (IC₅₀=15-50 nM), PP3 (IC₅₀=3.7-4 nM), PP4 (IC₅₀=0.1 nM), PP5 (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation ^[2].

HY-127085

Acanthifolicin Acanthifolic acid	Structural Classification Natural Products Marine natural products Source classification Sponge	Phosphatase
Acanthifolicin, a derivative of Okadaic acid (HY-N6785), is a protein phosphatase inhibitor. Acanthifolicin inhibits protein phosphatase-1 (PP1) and PP2 with IC₅₀ values of 20 nM and 1 nM, respectively .

HY-N1743

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)	Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Moraceae Broussonetia kazinoki Sieb. et Zucc. Disease Research Fields	Phosphatase
1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes .

HY-N6596

7-Hydroxy-4H-chromen-4-one 7-Hydroxychromone	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Celastraceae Phenols Tripterygium wilfordii Hook. f. Plants Disease Research Fields Cancer	Src
7-Hydroxychromone is a Src kinase inhibitor with an IC₅₀ of <300 μM.

HY-N8917

(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane	Dracaena cochinchinensis (Lour.) S. C. Chen Structural Classification Source classification Phenols Polyphenols Agavaceae Plants	Phosphatase
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavonoid. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane increases the level of *alkaline phosphatase* (ALP)** activity. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane promotes mesenchymal stem cells (MSCs) osteogenesis, but cannot enhance MSCs proliferation. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane can be used for osteoporosis research .

HY-124896

Bonannione A 6-Geranylnaringenin; Mimulone	Paulownia tomentosa (Thunb.) Steud. Scrophulariaceae Plants	Phosphatase Apoptosis Autophagy
Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent *protein tyrosine phosphatase* 1B (PTP1B) inhibitor with an IC₅₀ of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy** through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity ^[2] .

HY-N3267

Methyl pseudolarate B	Structural Classification Pinaceae Terpenoids Source classification Diterpenoids Pseudolarix amabilis (J. Nelson) Rehder Plants	Phosphatase
Methyl pseudolarate B, a natural diterpenoid, is a *protein tyrosine phosphatase* 1B (PTP1B)** (Phosphatase) inhibitor with an IC₅₀ value of 10.9 μM .

HY-N4185

Licoflavone A 1 Publications Verification	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Flavones Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields	Phosphatase
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC₅₀ of 54.5 μM .

HY-123298

Chrysotoxine	Structural Classification Monophenols Orchidaceae Source classification Phenols Plants Dendrobium pulchellum Roxb. et Lindl. :Lindl.	Src Akt Apoptosis
Chrysotoxine is a dual inhibitor of *Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis* level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research ^[2].

HY-N7160

2-Hydroxy-3-methylanthraquinone	Quinones Structural Classification Anthraquinones Source classification Rubiaceae Plants Hedyotis diffusa Willd.	Src Apoptosis
2-Hydroxy-3-methylanthraquinone (compound 1) is a natural compound isolated from a water extract of Hedyotis diffusa WILLD. 2-Hydroxy-3-methylanthraquinone shows inhibitory activity against protein tyrosine kinases v-src and pp60src, and induces growth arrest and apoptosis in the HepG2 cancer cells .

HY-B0579

Cyclosporin A Maximum Cited Publications 121 Publications Verification Cyclosporine A; Ciclosporin A; CsA	Structural Classification Natural Products Microorganisms Classification of Application Fields Anti-aging Source classification Inflammation/Immunology Disease Research Fields Cancer	Molecular Glues Complement System Antibiotic Cyclophilin
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-W008385

H-HoArg-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

HY-N10649

PTP1B-IN-21	Quinones Structural Classification Anthraquinones Rubiaceae Knoxia valerianoides Thorel ex Pitard Plants	Phosphatase
PTP1B-IN-21 is a selective inhibitor of *protein tyrosine phosphatase* 1B (PTP1B; IC₅₀*=1.56 μM) over the highly homologous T-cell protein tyrosine phosphatase* (TCPTP; IC₅₀>100 μM), which is a key target for type 2 diabetes inhibition .

HY-B0579R

Cyclosporin A (Standard)	Structural Classification Natural Products Microorganisms Source classification	Molecular Glues Complement System Antibiotic Cyclophilin
Cyclosporin A (Standard) is the analytical standard of Cyclosporin A. This product is intended for research and analytical applications. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-N4127

3'-Demethylnobiletin	Monophenols Flavonoids Classification of Application Fields Flavones Source classification Rutaceae Phenols Plants Disease Research Fields Citrus Cancer	Src STAT
3'-Demethylnobiletin, a derivative of Nobiletin, is a polymethoxyflavonoid in citrus fruits . Nobiletin exhibits anticancer activity and inhibits tumor angiogenesis by regulating Src, FAK, and STAT3 signaling ^[2].

HY-121418

Lusianthridin	Natural Products other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	c-Myc
Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling .

HY-N2111

Momordicoside A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Plants Disease Research Fields Momordica charantia Linn.	Phosphatase
Momordicoside A is isolated from Momordica charantia L. Momordicoside A has the inhibitory effect on *protein tyrosine phosphatase* (PTP1B)** .

HY-N10648

PTP1B-IN-20	Quinones Structural Classification Anthraquinones Rubiaceae Knoxia valerianoides Thorel ex Pitard Plants	Phosphatase
PTP1B-IN-20 is a selective inhibitor of *protein tyrosine phosphatase* 1B (PTP1B; IC₅₀*=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase* (TCPTP; IC₅₀=78.0 μM), which is a key target for type 2 diabetes inhibition .

HY-N8789

2-Hydroxymethyl-3-hydroxyanthraquinone	Quinones Anthraquinones Rubiaceae Plants Morinda officinalis How	Phosphatase
2-Hydroxymethyl-3-hydroxyanthraquinone is an antiosteoporotic compound that inhibits osteoclastic *tartrate-resistant acid phosphatase* (TRAP)** activity .

HY-114336

Enocyanin 2 Publications Verification	Anthocyans Flavonoids Classification of Application Fields Source classification Vitis vinifera cv. Zalema Plants Vitaceae Disease Research Fields Inflammation/Immunology	Phosphatase
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity .

HY-N2247

Guaiacin	Zingiber officinale Roscoe Structural Classification Classification of Application Fields Source classification Lignans Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Disease Research Fields Zingiberaceae	Phosphatase
Guaiacin is a arylnaphthalene type lignin isolated from the barks of Machilus thunbergii SIEB. et ZUCC (Lauraceae). Guaiacin significantly increases alkaline phosphatase activity and osteoblast differentiation .

HY-N15220

Dipsacus saponin X	Structural Classification Polysaccharides Caprifoliaceae Source classification Dipsacus asper Wall. Plants Saccharides	Endogenous Metabolite Phosphatase
Dipsacus saponin X (compound 7) is a triterpenoid saponin that stimulates the proliferation of UMR106 cells and increases alkaline phosphatase activity in UMR106 cells (4 μM) .

HY-N15231

Dipsacus saponin XII	Structural Classification Polysaccharides Caprifoliaceae Source classification Dipsacus asper Wall. Plants Saccharides	Endogenous Metabolite Phosphatase
Dipsacus saponin XII (compound 6) is a triterpenoid saponin that stimulates the proliferation of UMR106 cells and increases alkaline phosphatase activity in UMR106 cells (4 μM) .

HY-N0896

Inulicin 1 Publications Verification 1-O-Acetylbritannilactone	Phyllodium pulchellum (L.) Desv. Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Inflammation/Immunology Disease Research Fields	NF-κB COX
Inulicin (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of *Src* and FAK. Inulicin (1-O-Acetylbritannilactone) inhibits LPS-induced *PGE₂* production and *COX-2* expression, and NF-κB activation and translocation.

HY-N12736

Dehydrodanshenol A	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Source classification Diterpenoids Plants	Phosphatase
Dehydrodanshenol A is a non-competitive inhibitor of Protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ value of 8.5 μM. Dehydrodanshenol A can be used in diabetes-related research .

HY-N6650

Isotanshinone IIA	Quinones Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Metabolic Disease Plants Naphthalene Quinones Disease Research Fields	Phosphatase
Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC₅₀ 0f 11.4 μM.

HY-N0374

Licochalcone C 2 Publications Verification	Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields	Glycosidase
Licochalcone C could inhibit α-glucosidase, with IC₅₀s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively.

Cat. No.	Product Name	Chemical Structure

HY-12047S

Ponatinib-d8
Ponatinib-d₈ is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

HY-10181S

Dasatinib-d8
Dasatinib-d₈ is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.

HY-B0537AS

Pentamidine-d4 dihydrochloride

Pentamidine-d₄ (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

HY-10181S1

Dasatinib-d4

Dasatinib-d₄ (BMS-354825-d₄) is deuterium labeled Dasatinib. Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The K_is are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC₅₀s of <1.0 nM and 0.5 nM, respectively ^[2]. Dasatinib also induces apoptosis and autophagy.

HY-10158S

Bosutinib-d8
Bosutinib-d₈ is a deuterium labeled Bosutinib. Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively[1][2].

HY-133794S

Dasatinib N-oxide-d8
Dasatinib N-oxide-d₈ is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].

HY-B0579S2

Cyclosporin A acetate-d4
Cyclosporin A acetate-d₄ (Cyclosporine A acetate-d₄; Ciclosporin A acetate-d₄) is a deuterium labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM ^[2]. Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-112096S

eCF506-d5
eCF506-d₅ is deuterated labeled eCF506 (HY-112096). eCF506 is a highly potent and orally bioavailable inhibitor of the non-receptor tyrosine kinase *Src* with an IC₅₀ of less than 0.5 nM.

HY-W008385S

H-HoArg-OH-d4
H-HoArg-OH-d₄ is a deuterium labeled H-HoArg-OH (HY-W008385). H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

HY-10234S

Saracatinib-d3
Saracatinib-d3 (AZD0530-d3) (ZG5129) is the deuterium-labeled analog of Saracatinib (HY-10234). Saracatinib-d3 is an inhibitor of the *Src* kinase, which can inhibit severe sepsis caused by bacterial or various microbial infections .

HY-B0579S3

Cyclosporin A-13C2,d4

Cyclosporin A- ¹³C₂,d₄ (Cyclosporine A- ¹³C₂,d₄; Ciclosporin A- ¹³C₂,d₄) is a ¹³C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC₅₀ of 5 nM ^[2]. Cyclosporin A also inhibits CD11a/CD18 adhesion .

HY-B2006S

Fenvalerate-d5
Fenvalerate-d₅ is the deuterium labeled Fenvalerate. Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC50 of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide[1].

HY-B0579S

Cyclosporin A-d4
Cyclosporin A-d₄ is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

HY-13632S5

Exemestane-13C,d2
Exemestane- ¹³C,d₂ is ¹³C and deuterated labeled Exemestane (HY-13632). Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC₅₀s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research ^[2].

HY-10230S

Midostaurin-d5
Midostaurin-d₅ is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

HY-13756S

Tacrolimus-13C,d2
Tacrolimus- ¹³C,d₂ is a ¹³C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].

HY-N2511S

Trimyristin--d15
Trimyristin--d₁₅ is the deuterium labeled Trimyristin. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively[1].

HY-106827S1

Trimegestone-13C,d3

Trimegestone- ¹³C,d₃ is ¹³C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC₅₀ value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC₅₀=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes ^[2].

HY-13342AS

Apatinib-d8 free base

Apatinib-d₈ (free base) is the deuterium labeled Apatinib free base[1]. Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ[2][3][4].

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