1. Gene
  2. Tyr - tyrosinase Gene

Tyr - tyrosinase Gene

Mus musculus

Also known as c; Oca1; skc35; albino

Gene ID: 22173 | Gene type: protein coding

About Tyr

Summary

Enables protein homodimerization activity. Acts upstream of or within several processes, including melanin biosynthetic process; pigmentation; and thymus development. Located in melanosome. Is expressed in central nervous system; eye; head mesenchyme; mesenchyme derived from neural crest; and skin. Used to study buphthalmos and oculocutaneous albinism. Human ortholog(s) of this gene implicated in melanoma (multiple); ocular albinism; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (Tyrosinase). [provided by Alliance of Genome Resources, Apr 2022]

Tyr Products(2)

mRNA Protein Name
NM_001317397.1 NP_001304326.1 tyrosinase isoform 2 precursor
NM_011661.5 NP_035791.1 tyrosinase isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
9918801 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9918801 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
9918801 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
9548375 MGI
acts upstream of or within melanin biosynthetic process IMP
IMP: Inferred from mutant phenotype
7665913 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
9548375 MGI
acts upstream of or within thymus development IMP
IMP: Inferred from mutant phenotype
10890980 MGI
Cellular Component GO Annotation Evidence Reference Source
located in melanosome IDA
IDA: Inferred from direct assay
9918801 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosinase

albino locus protein

monophenol monooxygenase

Orthologs Information

Species Symbol Source ID
Homo sapiens Tyr NCBI NCBI:7299
Canis familiaris Tyr NCBI NCBI:403405
Macaca fascicularis Tyr NCBI NCBI:102141480
Susscrofa domestica Tyr NCBI
Leporidae Tyr NCBI
Rattus norvegicus Tyr NCBI NCBI:308800
Macaca mulatta Tyr NCBI NCBI:705792