1. Gene
  2. TYR - Tyr tyrosinase Gene

TYR - Tyr tyrosinase Gene

Rattus norvegicus
Gene ID: 308800 | Gene type: protein coding

About TYR

Summary

Predicted to enable copper ion binding activity; protein homodimerization activity; and Tyrosinase activity. Involved in several processes, including response to UV; response to cAMP; and response to vitamin D. Located in cytosol and nucleus. Used to study oculocutaneous albinism. Human ortholog(s) of this gene implicated in melanoma (multiple); ocular albinism; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (Tyrosinase). [provided by Alliance of Genome Resources, Apr 2022]

TYR Products(1)

mRNA Protein Name
NM_001107535.1 NP_001101005.1 tyrosinase precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in pigmentation IMP
IMP: Inferred from mutant phenotype
15760344 RGD
involved in response to UV IEP
IEP: Inferred from expression pattern
6175546 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
6175546 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
6175546 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosinase

Orthologs Information

Species Symbol Source ID
Homo sapiens TYR NCBI NCBI:7299
Canis familiaris TYR NCBI NCBI:403405
Macaca fascicularis TYR NCBI NCBI:102141480
Mus musculus TYR NCBI NCBI:22173
Susscrofa domestica TYR NCBI
Leporidae TYR NCBI
Macaca mulatta TYR NCBI NCBI:705792