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Ganoapplanoid F

" in MedChemExpress (MCE) Product Catalog:

1677

Inhibitors & Agonists

4

Screening Libraries

30

Fluorescent Dye

51

Biochemical Assay Reagents

65

Peptides

6

MCE Kits

49

Inhibitory Antibodies

297

Natural
Products

302

Recombinant Proteins

67

Isotope-Labeled Compounds

73

Antibodies

10

Click Chemistry

242

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N12604
    Penicisteck acid F

    		NF-κB Others
    Penicisteck acid F (Compound 2) is a Marine derived tanzanic acid derivative that is a NF-κB inhibitor. Penicisteck acid F inhibits osteoclast expression by decreasing RANKL-induced IκBα degradation, NF-κB p65 nuclear translocation, NFATc1 activation and nuclear translocation, and related mRNA expression. Penicisteck acid F can be used in osteoporosis research .
    Penicisteck acid F
  • HY-N1208
    Spiradine F

    O-Acetylspiradine G; Spiradine G acetate

    		 Others Cardiovascular Disease
    Spiradine F is a main alkaloidal component of spiraea japonioa L. fil. Spiradine F derivative can inhibit platelet-activating factor (PAF)-induced platelet aggregation .
    Spiradine F
  • HY-113246
    15-keto-Prostaglandin F2a

    15-keto-PGF2α

    		 Prostaglandin Receptor Endogenous Metabolite Endocrinology
    15-keto-Prostaglandin F2α (15-keto-PGF2α) is a metabolite of Prostaglandin F2α. Prostaglandin F2α. Prostaglandin F2α is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist and plays a key role in the onset and progression of labour .
    15-keto-Prostaglandin F2a
  • HY-146232
    F 13714

    F 14679

    		 5-HT Receptor Others
    F 13714 (F 14679) is a prototypical 5-HT1A agonist with a pKi of 10.23. F 13714 induces large Ca 2+ responses .
    F 13714
  • HY-115969
    F-17

    		Bacterial Infection
    F-17 is a potential inhibitor of virulence factor. F-17 shows very significant inhibitory effect on biofilm, elastase, pyocyanin, and swarming motility. F-17 also shows a good binding effect on LasR and PqsR. F-17 has no obvious cytotoxicity .
    F-17
  • HY-P2098
    Alamethicin F 50

    		Antibiotic Bacterial Fungal Infection
    Alamethicin F 50 is an antibiotic. Alamethicin F 50 is composed of membrane-active peptide, containing 75% Alamethicin F 50/5 and 10% Alamethicin F 50/7. Alamethicin F 50 is exhibits antifungal and antibacterial activity by disrupting the integrity of microbial cell membranes, resulting in leakage of cell contents and death of the microorganisms. Alamethicin F 50 is able to reduce the surface tension of water, which can be used as a surfactant or detergent .
    Alamethicin F 50
  • HY-P990221
    Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)

    		Interleukin Related Others
    Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-17F.
    Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)
  • HY-106902
    F-1394

    		Acyltransferase Cardiovascular Disease
    F-1394 is an orally active acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor that inhibits dietary cholesterol absorption in mice. F-1394 can be used in cardiovascular disease research .
    F-1394
  • HY-113824
    RID-F

    Ridaifen-F

    		 Proteasome Cancer
    RID-F (Ridaifen-F), a Tamoxifen (HY-13757A) derivative, is a nonpeptidic proteasome inhibitor. RID-F inhibits human 20S proteasome activity, with IC50s of 0.64, 0.34, and 0.43 μM for CT-L, T-L, and PGPH, respectively .
    RID-F
  • HY-125349
    A-83016F

    		Antibiotic Infection
    A-83016F is an antibiotic. A-83016F has weak antimicrobial activity. A-83016F can be isolated from the culture broth of an unidentified actinomycete designated A83016 .
    A-83016F
  • HY-N6217
    F-14329

    		Endogenous Metabolite Others
    F-14329 is a tetramic acid fungal metabolite .
    F-14329
  • HY-N7223
    Lappaol F

    		YAP Apoptosis Cancer
    Lappaol F, a lignin, is an anticancer agent. Lappaol F inhibits YAP mRNA and protein level. Lappaol F inhibits tumor cell growth by inducing cell cycle arrest. Lappaol F induces cancer cell apoptosis, and inhibits tumor growth. Lappaol F can be isolated from Arctium lappa Linne (Asteraceae) .
    Lappaol F
  • HY-D0159
    ZnAF-1F

    		Fluorescent Dye Others
    ZnAF-1F is a potent fluorophore for with an Kd value of 2.2 nM. ZnAF-1F can be used as fluorescent probes for Zn 2+ in cells. ZnAF-1F shows λ excitation of 489 nm and λ emission of 514 nm .
    ZnAF-1F
  • HY-106031
    F-14512

    		Topoisomerase Cancer
    F-14512 is a targeted cytotoxic compound that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 combines an epipodophyllotoxin core that targets topoisomerase II with a spermine group that acts as a cell delivery vehicle, with improved selectivity for tumor cells. F-14512 exhibits significant cytotoxicity against cells with high PTS activity and demonstrates high potency in multiple human cell lines (median IC50=0.18 μM). In the MX1 breast tumor xenograft model, F-14512 exhibits potent antitumor activity .
    F-14512
  • HY-N8619
    Minimolide F

    		Others Cancer
    Minimolide F is a sesquiterpene lactone. Minimolide F has inhibitory activity against human nasopharyngeal cancer cells. Minimolide F can be used for the research of cancer .
    Minimolide F
  • HY-19886
    F 16915

    		Drug Intermediate Cardiovascular Disease
    F 16915, a Docosahexaenoic Acid (DHA, HY-B2167) derivative, is a potent pro-agent of DHA. F 16915 can prevent heart failure-induced atrial fibrillation .
    F 16915
  • HY-N10952
    Epicornuin F

    		Others Cancer
    Epicornuin F is a prenylated flavonoid. Epicornuin F can be isolated from the leaves of Epimedium brevicornu. Epicornuin F has the cytotoxic activity against HepG2 cells with an IC50 value of 33.4 μM. Epicornuin F can be used for the research of cancer .
    Epicornuin F
  • HY-153839
    ODN 4084-F

    		Toll-like Receptor (TLR) Inflammation/Immunology
    ODN 4084-F is a class B (‘broadly-active’) inhibitory ODN. ODN 4084-F is potent inhibitor of TLR9-induced B cells and macrophages.
    ODN 4084-F
  • HY-153839A
    ODN 4084-F sodium

    		Toll-like Receptor (TLR) Inflammation/Immunology
    ODN 4084-F sodium is a class B (‘broadly-active’) inhibitory ODN. ODN 4084-F sodium is potent inhibitor of TLR9-induced B cells and macrophages.
    ODN 4084-F sodium
  • HY-N10380
    Inonotusol F

    		Others Metabolic Disease
    Inonotusol F is a triterpene isolated from Inonotus obliquus. Inonotusol F shows hepatoprotective effects against D-galactosamine-induced WB-F344 cell damage .
    Inonotusol F
  • HY-15583
    Auristatin F

    		ADC Cytotoxin Microtubule/Tubulin Cancer
    Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .
    Auristatin F
  • HY-N10471
    F3226-1387

    		Parasite Endogenous Metabolite Infection
    F3226-1387 is a potent Entamoeba histolytica O-acetylserine sulfhydrylase EhOASS3 inhibitor with an IC50 value of 38 μM. F3226-1387 can suppress the growth of the amoeba .
    F3226-1387
  • HY-161758
    F0045(S)

    		Influenza Virus Infection
    F0045(S) is a potent influenza hemagglutinin inhibitor with a KD value of 6.1 µM. F0045(S) protects human cells from influenza infection .
    F0045(S)
  • HY-113732
    Kazinol F

    		SARS-CoV Infection Inflammation/Immunology
    Kazinol F is a polyphenol from Broussonetia papyrifera. Kazinol F also is an effective Mpro inhibitor. Kazinol F has interaction with both the catalytic residues (His41 and Cys145) of Mpro and exhibits good binding affinity. Kazinol F can be used for the research of COVID-19 .
    Kazinol F
  • HY-N14022
    Glidobactin F

    		Antibiotic Fungal Infection Cancer
    Glidobactin F is an anti-tumor antibiotic. Glidobactin F has the activity against pathogenic fungi and yeast. Glidobactin F also extends the survival of mice inoculated with leukemia P388 cells .
    Glidobactin F
  • HY-N11430
    F1839-I

    		HIV Infection
    F1839-I is a compound that can be isolated from Stachybotrys. F1839-I has weak cytotoxicity and anti-HIV activity with an IC50 value of 15.6 μM .
    F1839-I
  • HY-138881
    Lenalidomide-6-F

    		Ligands for E3 Ligase Cancer
    Lenalidomide-6-F is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-6-F can be connected to the ligand for protein by a linker to form PROTAC .
    Lenalidomide-6-F
  • HY-133220A
    Guajadial F

    		Others Cancer
    Guajadial F is a natural product that can be found in Psidium guajava. Guajadial F shows cytotoxicity .
    Guajadial F
  • HY-N12241
    Sterebin F

    		Others Others
    Sterebin F is a steroid isolated from the Stevia rebaudiana leaves. Sterebin F has hypoglycemic activity .
    Sterebin F
  • HY-N0861
    Ikarisoside F

    Ikarisoside-F; Icarisoside-F

    		 Others Cancer
    Ikarisoside F is a flavonol glycoside from Vancouveria hexandra; could bind to AdoHcy hydrolase.
    Ikarisoside F
  • HY-171148
    F1-RIBOTAC

    		PROTACs Cancer
    F1-RIBOTAC is a ribonuclease-targeting chimeras (RIBOTACs). F1-RIBOTAC decreases QSOX1-a mRNA expression level in an RNase L-dependent manner. F1-RIBOTAC can be used for the research of cancer . (Pink: RNA ligand (HY-168460); Black: linker (HY-W008005); Blue: RNase L ligand (HY-168452))
    F1-RIBOTAC
  • HY-149556
    MTX-241F

    		EGFR PI3K Cancer
    MTX-241F is a selective small molecule inhibitor targeting EGFR and PI3 kinase family members. MTX-241F is able to penetrate the blood-brain barrier and control tumor growth over the long term. MTX-241F exhibits radiosensitizing activity in patient-derived DIPG neurospheres and may be used in the study of diffuse intrinsic pontine glioma (DIPG) .
    MTX-241F
  • HY-D0159A
    ZnAF-1F tetraTFA

    		Fluorescent Dye Others
    ZnAF-1F tetraTFA is a potent fluorophore for with an Kd value of 2.2 nM. ZnAF-1F tetraTFA can be used as fluorescent probes for Zn 2+ in cells. ZnAF-1F tetraTFA shows λ excitation of 489 nm and λ emission of 514 nm .
    ZnAF-1F tetraTFA
  • HY-N13098
    Elatoside F

    		NF-κB Inflammation/Immunology
    Elatoside F is a triterpenoid saponin with anti-inflammatory activity. Elatoside F inhibits lipopolysaccharide-induced nitric oxide production and nuclear factor NF-κB activation. Elatoside F can be isolated from Aralia elata in one step.
    Elatoside F
  • HY-N8386
    Berkeleylactone F

    		Antibiotic Infection Cancer
    Berkeleylactone F is an antibiotic macrolide compound. Berkeleylactone F showed modest inhibition of CCRF-CEM leukemia cells .
    Berkeleylactone F
  • HY-125831
    ITIC-4F

    		Biochemical Assay Reagents Others
    ITIC-4F is an indacenodithienothiophene (IDTT)-based postfullerene electron acceptor. ITIC-4F has broad applicability in high-efficiency binary and ternary single-junction as well as tandem polymer solar cells (PSCs) .
    ITIC-4F
  • HY-N10661
    Ipomoeassin F

    Ipom-F

    		 SARS-CoV Infection Cancer
    Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .
    Ipomoeassin F
  • HY-154850
    F-CRI1

    		STING Cancer
    F-CRI1 is a potent STING agonist with a Kd value of 40.62 nM. F-CRI1 is a radioactive probe with 18F-labeled modification. F-CRI1 can be used to study STING visualization in the tumor microenvironment .
    F-CRI1
  • HY-W590849
    F1874-108

    		Endogenous Metabolite Metabolic Disease
    F1874-108 is an inhibitor of brassinosteroid biosynthesis and signal transduction .
    F1874-108
  • HY-139132
    Met-F-AEA

    		Apoptosis Cancer
    Met-F-AEA is a metabolically stable anandamine analogue. Met-F-AEA inhibits cell growth by activating apoptosis. Met-F-AEA has antitumor activity .
    Met-F-AEA
  • HY-P2929
    PNGase F
    1 Publications Verification

    		 Biochemical Assay Reagents Glycosidase Cancer
    PNGase F, a glycosidase, catalyzes the cleavage of an internal glycoside bond in an oligosaccharide. PNGase F removes nearly all N-linked oligosaccharides from glycoproteins. PNGase F can release N-glycans from glycoproteins in glycoanalytical workflows .
    PNGase F
  • HY-N2241
    Hosenkoside F

    (+)-Hosenkoside F

    		 Others Inflammation/Immunology
    Hosenkoside F is a baccharane glycoside isolated from the seeds of impatiens balsamina.
    Hosenkoside F
  • HY-N3518
    Mulberroside F

    		Tyrosinase Metabolic Disease
    Mulberroside F is one of the main bioactive constituents in mulberry (Morus alba L.) . Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation. Mulberroside F also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation .
    Mulberroside F
  • HY-N14968
    Enniatin F

    		Parasite Fungal Infection
    Enniatin F has insecticidal and antifungal activity. Enniatin F also can inhibit acyl-CoA, cholesterol acyltransferase (ACAT) .
    Enniatin F
  • HY-N14210
    Epithienamycin F

    		Antibiotic Bacterial Infection
    Epithienamycin F is a carbapenem antibiotic. Epithienamycin F has anti-Gram-positive bacteria and anti-Gram-negative bacteria activity .
    Epithienamycin F
  • HY-15583S
    Auristatin F-d8

    		Isotope-Labeled Compounds ADC Cytotoxin Microtubule/Tubulin Cancer
    Auristatin F-d8 is deuterium labeled Auristatin F (HY-15583). Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .
    Auristatin F-d8
  • HY-P10310
    F9170

    		HIV Infection
    F9170 is an amphipathic peptide with an activity of inactivate HIV-1 virions. F9170 targets the conserved cytoplasmic tail of HIV-1 env and disrupts the integrity of the viral membrane. F9170 is able to cross the blood-brain barrier (BBB) .
    F9170
  • HY-19463A
    F15845

    		Sodium Channel Cardiovascular Disease
    F 15845 is a highly effective persistent sodium current blocker. F 15845 also is a cardioprotective agent, has anti-ischemic activity and exerts short- and long-term cardioprotection after myocardial infarction. F 15845 can be used for the research of myocardium functional impairment .
    F15845
  • HY-N3532
    Cannabisin F

    		Sirtuin Neurological Disease Inflammation/Immunology
    Cannabisin F is a SIRT1 modulator. Cannabisin F, as a hempseed lignanamide, can be used for the research of anti-inflammatory and anti-oxidative. Cannabisin F may be a potential agent of neurodegenerative diseases as modulators of SIRT1/NF-κB and Nrf2 .
    Cannabisin F
  • HY-163436
    F44-A13

    		FXR Cytochrome P450 RAR/RXR PPAR ROR Metabolic Disease
    F44-A13 is an orally active and highly selective farnesoid X receptor (FXR) antagonist with an IC50 value of 1.1 μM. F44-A13 can optimize cholesterol metabolism and reduce its activity by inducing CYP7A1 expression. F44-A13 reduces levels of cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) in mouse models. F44-A13 can be used in the study of metabolic diseases associated with lipid disorders .
    F44-A13

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