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Ca<sup>2 </sup>?transients

" in MedChemExpress (MCE) Product Catalog:

1742

Inhibitors & Agonists

4

Screening Libraries

30

Fluorescent Dye

19

Biochemical Assay Reagents

109

Peptides

3

Inhibitory Antibodies

128

Natural
Products

83

Recombinant Proteins

837

Isotope-Labeled Compounds

19

Antibodies

11

Click Chemistry

30

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-126906
    Milbemycin A4

    		Antibiotic P-glycoprotein Cancer
    Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity [1]sup>[2].
    Milbemycin A4
  • HY-W011509
    CyPPA

    		Potassium Channel Neurological Disease
    CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels [1]sup .
    CyPPA
  • HY-N6746
    Citrinin

    NSC 186

    		 Bacterial Fungal Endogenous Metabolite Apoptosis Infection Neurological Disease Cancer
    Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin shows significant antitumor effects in a mouse model of breast cancer induced by DMBA (HY-W011845). Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. In addition, Citrinin has antibacterial and neuroprotective activities [1]sup [2]sup [3]sup [4]
    Citrinin
  • HY-12741
    LDN-212320
    5 Publications Verification

    LDN-0212320; OSU-0212320

    		 EAAT Neurological Disease
    LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC [1]sup .
    LDN-212320
  • HY-N12231
    Carbazomycin B

    		Antibiotic Bacterial Lipoxygenase Infection Cancer
    Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC50 Of 1.5 µM [1]sup>[2]sup>[3]sup>[4].
    Carbazomycin B
  • HY-108166
    Hydroxystilbamidine

    		Fluorescent Dye Inflammation/Immunology
    Hydroxystilbamidine, a dye capable of binding to both DNA and RNA, is a powerful inhibitor of cellular ribonucleases. Hydroxystilbamidine is a retrograde fluorescent tracer and a histochemical stain [1]sup .
    Hydroxystilbamidine
  • HY-145128
    GR103545

    		Opioid Receptor Neurological Disease
    GR103545 is a potent and selective agonist of the κ-opioid receptor (κ-OR). 11GR103545 is a radiotracer for imaging κ-OR in vivo [1]sup .
    GR103545
  • HY-161119
    Drpitor1a

    		Dynamin Reactive Oxygen Species Cardiovascular Disease Cancer
    Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer [1]sup .
    Drpitor1a
  • HY-126906R
    Milbemycin A4 (Standard)

    		Antibiotic P-glycoprotein Cancer
    Milbemycin A4 (Standard) is the analytical standard of Milbemycin A4. This product is intended for research and analytical applications. Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity [1]sup> .
    Milbemycin A4 (Standard)
  • HY-Y0850U
    PVA (Mw 31000, 87-89% hydrolyzed, ～630 polymerization)

    Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ～630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ～630 polymerization)

    		 Biochemical Assay Reagents Others
    PVA (Mw 31000, 87-89% hydrolyzed, ～630 polymerization) (Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ～630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ～630 polymerization)) is a biocompatible, biodegradable, nontoxic and hydrophilic synthetic polymer. PVA (Mw 31000, 87-89% hydrolyzed, ～630 polymerization) can be used to produce bone tissue engineering scaffold [1]sup .
    PVA (Mw 31000, 87-89% hydrolyzed, ～630 polymerization)
  • HY-15306S
    Eltrombopag-13C4
    1 Publications Verification

    SB-497115-<sup>13sup>C4

    		 Thrombopoietin Receptor Bacterial Apoptosis Infection Cardiovascular Disease Cancer
    Eltrombopag- 13C4 (SB-497115- 13C4) is 13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells [2] .
    Eltrombopag-13C4
  • HY-D1583
    Cyanine5 DBCO
    1 Publications Verification

    DBCO-Cy5; Cyanine5 dibenzocyclooctyne

    		 Fluorescent Dye Others
    Cyanine5 DBCO (DBCO-Cy5) is a low-toxicity azide reactive probe (NIR fluorescent dye), for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm) [2].
    Cyanine5 DBCO
  • HY-156013
    CA inhibitor 2

    		Carbonic Anhydrase Endocrinology Cancer
    CA inhibitor 2 (Compound 4H) is a carbonic anhydrase inhibitor (IC50: 0.033 μM) .
    CA inhibitor 2
  • HY-D1327
    Cyanine3 azide chloride

    		Fluorescent Dye Others
    Cyanine3 azide chloride, an analog of Cy3 azide, is a potent green fluorescent dye. Cyanine3 azide chloride uses click chemistry coupled with Alkyne-labeled proteins. Cyanine3 azide chloride can be detected by fluorometers, imagers, and microscopes. (λex=684 nm, λem=710 nm) [1]sup >. Cyanine3 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Cyanine3 azide chloride
  • HY-N11122
    7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol

    		Others Others
    7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol is a cuminol glycoside. 7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol can be isolated from Rhodiola rosea sup>[1].
    7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol
  • HY-N8824
    Maackiaflavanone

    		Others Others
    Maackiaflavanone (compound 4) is a kind of prenylated flavanone. Maackia can be isolated from M. amurensi.
    Maackiaflavanone
  • HY-B0596S
    Taltirelin-13C,d3

    TA-0910-<sup>13sup>C,d3

    		 Isotope-Labeled Compounds Apoptosis Thyroid Hormone Receptor Neurological Disease Endocrinology
    Taltirelin- 13C,d3 (TA-0910- 13C,d3) is 13C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca 2+ concentration (Ca 2+ release).
    Taltirelin-13C,d3
  • HY-139145S
    Etbicyphat-13C3

    Trimethylopropane phosphate-<sup>13sup>C3

    		 GABA Receptor Neurological Disease
    Etbicyphat- 13C3 is the 13C labeled Etbicyphat (HY-139145). Etbicyphat is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors[1][2].
    Etbicyphat-13C3
  • HY-103350
    CA-074
    15+ Cited Publications

    		 Cathepsin Neurological Disease Cancer
    CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
    CA-074
  • HY-N3872
    Ethyl β-D-glucopyranoside

    		Others Others
    Ethyl β-D-glucopyranoside (compound 10) is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellata LS.
    Ethyl β-D-glucopyranoside
  • HY-100350
    CA-074 methyl ester
    25+ Cited Publications

    Ca-074Me

    		 Cathepsin Neurological Disease Cancer
    CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.
    CA-074 methyl ester
  • HY-162344
    Ir-CA

    		Apoptosis Autophagy Cancer
    Ir-CA is an antitumor agent. Ir-CA can accumulate in mitochondria and induces mitochondria dysfunction. Ir-CA induces apoptosis and autophagy. Ir-CA initiates mitophagy and cell cycle arrest to kill Cisplatin (HY-17394)-resistant A549R cells. Ir-CA can effectively inhibit metastasis by inhibiting MMP-2/MMP-9 .
    Ir-CA
  • HY-W424792A
    O-Desmethyl Brinzolamide hydrochloride

    		Carbonic Anhydrase Drug Metabolite Neurological Disease
    O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a Kd of 0.136 nM for CA II and an IC50 of 165 nM for CA IV .
    O-Desmethyl Brinzolamide hydrochloride
  • HY-101093
    CA-170
    1 Publications Verification

    		 PD-1/PD-L1 Inflammation/Immunology Cancer
    CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes [2].
    CA-170
  • HY-134923
    CA77.1
    2 Publications Verification

    		 Autophagy Neurological Disease
    CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's disease research .
    CA77.1
  • HY-N8859
    Isoiridogermanal

    16-Hydroxyiridal

    		 Others Others
    Isoiridogermanal can be isolated from the extract of rhizomes of Iris tectorum Maxim. Isoiridogermanal is cytotoxic with IC50 values of 11 μM and 23 μM against MCF-7 and C32 cell lines.
    Isoiridogermanal
  • HY-156383
    SCO-PEG3-NHS

    		PROTAC Linkers Cancer
    SCO-PEG3-NHS is a PEG linker with a terminal imine(NH) group. SCO-PEG3-NHS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    SCO-PEG3-NHS
  • HY-N0215S11
    L-Phenylalanine-13C9,15N

    (S)-2-Amino-3-phenylpropionic acid-<sup>13sup>C9,<sup>15sup>N

    		 Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine- 13C9, 15N is the 13C- and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
    L-Phenylalanine-13C9,15N
  • HY-12542S
    Dantrolene-13C3

    F 368-<sup>13sup>C3

    		 Isotope-Labeled Compounds Glutathione Reductase Neurological Disease Inflammation/Immunology
    Dantrolene- 13C3 is the 13C3 labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.
    Dantrolene-13C3
  • HY-112698
    CA-5f

    		p62 Atg8/LC3 Autophagy Apoptosis Cancer
    CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity .
    CA-5f
  • HY-N0733S2
    Glucosamine-13C,15N hydrochloride

    D-(+)-Glucosamine-<sup>13sup>C,<sup>15sup>N hydrochloride; Chitosamine-<sup>13sup>C,<sup>15sup>N hydrochloride

    		 Isotope-Labeled Compounds Autophagy Endogenous Metabolite HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Inflammation/Immunology Cancer
    Glucosamine- 13C, 15N (hydrochloride) is the 13C and 15N labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, i
    Glucosamine-13C,15N hydrochloride
  • HY-B0271S1
    Pyrazinamide-13C,15N

    PyrazineCarboxamide-<sup>13sup>C,<sup>15sup>N; Pyrazinoic acid amide-<sup>13sup>C,<sup>15sup>N

    		 Autophagy Antibiotic Bacterial Isotope-Labeled Compounds Infection
    Pyrazinamide- 13C, 15N is 15N and 13C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
    Pyrazinamide-13C,15N
  • HY-111207
    CA224

    		CDK Apoptosis Cancer
    CA224 (Compound 1) is a selective and orally active Cdk4–cyclin D1 inhibitor with an IC50 of 6.2 µM. CA224 induces cell apoptosis and shows antitumor activity .
    CA224
  • HY-159122
    CA IX-IN-2

    		Carbonic Anhydrase Reactive Oxygen Species Apoptosis Cancer
    CA IX-IN-2 (Compound 9o) is an inhibitor for carbonic anhydrase (CA), that inhibits CA IX, CA XII and CA II with an IC50 of 5.6, 7.4 and 430 nM, respectively. CA IX-IN-2 inhibits the proliferation of cancer cell HCT-116, SW480, MDA-MB 231 and MCF-7, with IC50s of 14.63-29.33 μM. CA IX-IN-2 intercalates DNA, arrests cell cycle at G1/S phase, and induces apoptosis in MDA-MB-231. CA IX-IN-2 affects the mitochondrial membrane potential (MMP), increases the intracellular ROS levels, causes mitochondrial damage, and inhibits the cell migration of MDA-MB-231. CA IX-IN-2 exhibits antitumor efficacy in mouse models .
    CA IX-IN-2
  • HY-146252
    hCAXII-IN-4

    		Carbonic Anhydrase Cancer
    hCAXII-IN-4 (compound 5j) is a potent and selective CA XII inhibitor with an Ki value of 6.4 nM for human CA XII .
    hCAXII-IN-4
  • HY-137459
    Vocacapsaicin

    Ca-008

    		 TRP Channel Neurological Disease
    Vocacapsaicin (CA-008), a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin can provide meaningful and long-lasting pain relief .
    Vocacapsaicin
  • HY-137459A
    Vocacapsaicin hydrochloride

    Ca-008 hydrochloride

    		 TRP Channel Neurological Disease
    Vocacapsaicin (CA-008) hydrochloride, a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin hydrochloride can provide meaningful and long-lasting pain relief .
    Vocacapsaicin hydrochloride
  • HY-N0650S6
    L-Serine1-13C,15N

    (-)-Serine-<sup>13sup>C,<sup>15sup>N; (S)-Serine-<sup>13sup>C,<sup>15sup>N

    		 Isotope-Labeled Compounds Endogenous Metabolite Cancer
    L-Serine1- 13C, 15N is the 13C- and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
    L-Serine1-13C,15N
  • HY-Y0418S
    Dulcite-13C

    Dulcitol-<sup>13sup>C; Melampyrit-<sup>13sup>C; NSC 1944-<sup>13sup>C

    		 Isotope-Labeled Compounds Endogenous Metabolite Others
    Dulcite- 13C is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
    Dulcite-13C
  • HY-13771S1
    Ursodeoxycholic acid-13C

    Ursodeoxycholate-<sup>13sup>C; Ursodiol-<sup>13sup>C; UDCa-<sup>13sup>C

    		 Isotope-Labeled Compounds G protein-coupled Bile Acid Receptor 1 FXR Endogenous Metabolite Cancer
    Ursodeoxycholic acid- 13C is the 13C labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].
    Ursodeoxycholic acid-13C
  • HY-A0061S
    Trifluridine-13C,15N2

    Trifluorothymidine-<sup>13sup>C,<sup>15sup>N2; 5-Trifluorothymidine-<sup>13sup>C,<sup>15sup>N2; TFT-<sup>13sup>C,<sup>15sup>N2

    		 Thymidylate Synthase Nucleoside Antimetabolite/Analog HSV Orthopoxvirus Cancer
    Trifluridine- 13C, 15N2 is the 13C and 15N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].
    Trifluridine-13C,15N2
  • HY-112794
    Topanol CA

    		Others Others
    Topanol CA serves as an effective antioxidant and stabilizer for resins and light-colored rubber products.
    Topanol CA
  • HY-B0389S10
    D-Glucose-13C

    Glucose-<sup>13sup>C; D-(+)-Glucose-<sup>13sup>C; Dextrose-<sup>13sup>C

    		 Endogenous Metabolite Metabolic Disease
    D-Glucose- 13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
    D-Glucose-13C
  • HY-B0389S29
    D-Glucose-18O

    Glucose-<sup>18sup>O; D-(+)-Glucose-<sup>18sup>O; Dextrose-<sup>18sup>O

    		 Endogenous Metabolite Metabolic Disease Cancer
    D-Glucose- 18O is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules
    D-Glucose-18O
  • HY-13613S2
    Dutasteride-13C,15N,d

    GG 745-<sup>13sup>C,<sup>15sup>N,d; GI 198745-<sup>13sup>C,<sup>15sup>N,d

    		 5 alpha Reductase Apoptosis Isotope-Labeled Compounds Cancer
    Dutasteride- 13C, 15N,d is 15N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .
    Dutasteride-13C,15N,d
  • HY-13458S1
    Droxidopa-13C2,15N hydrochloride

    L-DOPS-<sup>13sup>C2,<sup>15sup>N hydrochloride; DOPS-<sup>13sup>C2,<sup>15sup>N hydrochloride; SM5688-<sup>13sup>C2,<sup>15sup>N hydrochloride

    		 Adrenergic Receptor Isotope-Labeled Compounds Neurological Disease
    Droxidopa- 13C2, 15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood–brain barrier[1][2].
    Droxidopa-13C2,15N hydrochloride
  • HY-66005S4
    Acetaminophen-13C2,15N

    Paracetamol-<sup>13sup>C2,<sup>15sup>N; 4-Acetamidophenol-<sup>13sup>C2,<sup>15sup>N; 4'-Hydroxyacetanilide-<sup>13sup>C2,<sup>15sup>N

    		 COX Bacterial Histone Acetyltransferase Parasite Endogenous Metabolite Inflammation/Immunology
    Acetaminophen- 13C2, 15N is the 13C and 15N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].
    Acetaminophen-13C2,15N
  • HY-15236S1
    PSI-6206-d1,13C,15N2

    RO 2433--d<sup>1sup>,<sup>13sup>C,<sup>15sup>N2; GS-331007--d<sup>1sup>,<sup>13sup>C,<sup>15sup>N2

    		 HCV Isotope-Labeled Compounds Infection
    PSI-6206-d1, 13C, 15N2 is 15N and 13C labeled PSI-6206 (HY-15236). PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
    PSI-6206-d1,13C,15N2
  • HY-150782
    UNC-CA359

    		EGFR Cancer
    UNC-CA359 is a potent epidermal growth factor receptor (EGFR) inhibitor, with an IC50 value of 18 nM. UNC-CA359 exhibits strong anti-tumor activity, can be used to Chordoma research . UNC-CA359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    UNC-CA359
  • HY-N0215S9
    L-Phenylalanine-13C9,15N,d8

    (S)-2-Amino-3-phenylpropionic acid-<sup>13sup>C9,<sup>15sup>N,d8

    		 Isotope-Labeled Compounds Calcium Channel iGluR Endogenous Metabolite Metabolic Disease
    L-Phenylalanine- 13C9, 15N,d8 is the deuterium, 13C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
    L-Phenylalanine-13C9,15N,d8

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