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in vitro

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NEKs (1) 11β-HSD (1) 5-HT Receptor (11) Acyltransferase (7) ADC Cytotoxin (9) ADC Linker (2) Adenosine Deaminase (1) Adenosine Receptor (4) Adenylate Cyclase (1) Adrenergic Receptor (9) Akt (20) Aldehyde Dehydrogenase (ALDH) (3) Aldose Reductase (1) Amine N-methyltransferase (1) Amino Acid Derivatives (2) Aminoacyl-tRNA Synthetase (1) Aminopeptidase (1) AMPK (9) Amylases (1) Amyloid-β (16) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (17) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (106) Antibody-Drug Conjugates (ADCs) (1) Antifolate (1) Apelin Receptor (APJ) (2) Apolipoprotein (1) Apoptosis (182) Aryl Hydrocarbon Receptor (1) Atg8/LC3 (2) ATGL (1) ATM/ATR (4) ATP Synthase (1) Aurora Kinase (5) Autophagy (65) Bacterial (154) Bcl-2 Family (18) BCL6 (2) Bcr-Abl (3) BCRP (2) Beta-lactamase (4) Biochemical Assay Reagents (57) Bradykinin Receptor (1) Btk (3) c-Fms (4) c-Kit (3) c-Met/HGFR (4) c-Myc (3) Calcium Channel (12) Cannabinoid 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PROTAC Linkers (1) PROTACs (13) Protease Activated Receptor (PAR) (2) Proteasome (4) Protein Arginine Deiminase (1) Proton Pump (8) PTEN (2) Pyroptosis (1) Pyruvate Kinase (1) Radionuclide-Drug Conjugates (RDCs) (3) Raf (2) RAR/RXR (2) Ras (5) Reactive Oxygen Species (33) Renin (3) RET (3) Reverse Transcriptase (7) RGS Protein (1) Ribosomal S6 Kinase (RSK) (1) RIP kinase (1) ROR (2) ROS Kinase (2) RSV (3) RUNX (1) Salt-inducible Kinase (SIK) (1) SARS-CoV (46) Ser/Thr Kinase (1) Ser/Thr Protease (1) Serotonin Transporter (3) SGLT (1) SHMT (1) SHP2 (1) Sirtuin (3) Sodium Channel (8) Somatostatin Receptor (3) SphK (1) Src (6) SRPK (1) STAT (15) STING (2) Succinate Dehydrogenase (1) SWI/SNF Complex (1) Syk (3) TAM Receptor (6) Taste Receptor (1) Tau Protein (4) TET Protein (2) TGF-beta/Smad (4) TGF-β Receptor (1) Thrombin (3) Thymidylate Synthase (2) Thyroid Hormone Receptor (4) TNF Receptor (9) Toll-like Receptor (TLR) (19) Topoisomerase (19) Trace Amine-associated Receptor (TAAR) (1) Transmembrane Glycoprotein (2) Trk Receptor (5) TRP Channel (7) TrxR (1) Tryptophan Hydroxylase (2) TSH Receptor (3) Tyrosinase (5) URAT1 (2) Vasopressin Receptor (2) VD/VDR (2) VEGFR (11) Virus Protease (5) VSV (3) Wnt (2) Xanthine Oxidase (3) YAP (2) α-synuclein (2) β-catenin (6) β-glucuronidase (1) γ-secretase (5)
By Research Areas:	Cancer (698) Cardiovascular Disease (96) Endocrinology (36) Infection (397) Inflammation/Immunology (227) Metabolic Disease (163) Neurological Disease (198)
Click Chemistry:	Azide (1) Alkynes (4)
Oligonucleotides:	Nucleosides and their Analogs (1) Phospholipids (2) Solubilizing Agents (1) Freeze-drying Protective Agents (1) Cap Analogs (11) Antisense Oligonucleotides (2) Nucleotides and their Analogs (1) Pegylated Lipids (2) Liposomal Film-forming Agents (1) Aptamers (7) Emulsifiers (1) Cationic Lipids (6) Adjuvant (1) Sweetening Agents (1)

1658

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

128

Peptides

MCE Kits

Inhibitory Antibodies

274

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Dan family AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121573

α-Acetyldigoxin	Biochemical Assay Reagents	Cardiovascular Disease
α-Acetyldigoxin can be used in heart failure related research and is orally available. The bioavailability of α-Acetyldigoxin is lower than that of β-Acetyldigoxin when administered orally and intravenously .

HY-E70090

T7 RNA polymerase	DNA/RNA Synthesis	Others
T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg ²⁺, T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter .

HY-157316

TZ-NBD	Fluorescent Dye	Others
TZ-NBD is a dual-channel sensitive fluorescence probe that exhibits fast response, and excellent selectivity to detect biothiols in vitro and in vivo .

HY-N13139

Dexylosyltubeimoside Ⅲ	Others	Cancer
Dexylosyltubeimoside Ⅲ (compound 3) is a cyclic disoside that can be isolated from Actinostemma lobatum MAXIM. Dexylosyltubeimoside Ⅲ has in vitro anticancer activity and inhibits the growth of human esophageal cancer cell line ECA109 (IC50=22.37 μM), lung cancer cell line A549 (IC50=27.27 μM) and gastric cancer cell line MGC-803 (IC50=36.85 μM) .

HY-134375

cAIMP Cyclic Adenosine-inosine Monophosphate	NF-κB IFNAR	Inflammation/Immunology
cAIMP (Cyclic Adenosine-Inosine Monophosphate) is an effective synthetic cyclic dinucleotide. cAIMP activates IRF and NF-κB in the THP1 human monocyte reporter cell line (THP1-Dual). cAIMP induces the secretion of IFNs and pro-inflammatory cytokines in vitro in human blood, with an EC₅₀ of 6.4 μmol/L .

HY-P3516

Barusiban FE-200440	Oxytocin Receptor	Endocrinology
Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (K_i=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research .

HY-150145

Cy5-UTP	Biochemical Assay Reagents	Others
Cy5-UTP is a substrate for terminal deoxynucleotidyl transferase (TdT). Cy5-UTP can be used to lable RNA probes through in vitro transcription (Excitation/Emission: 650/665 nm). Cy5-labeled mRNA emits orange fluorescence .

HY-157390

DPP-4-IN-9	Dipeptidyl Peptidase	Metabolic Disease
DPP-4-IN-9 (compound 6l) is a potent inhibitor of dipeptidyl peptidase DPP-4 (IC₅₀: 8.22 nM). DPP-4-IN-9 has antihyperglycemic activity .

HY-162856

TRPV1-IN-2	TRP Channel	Neurological Disease
TRPV1-IN-2 ((R)-32) is a TRPV1 inhibitor. TRPV1-IN-2 has protective effects on ED epilepsy models .

HY-155241

α-Amylase/α-Glucosidase-IN-4	Glycosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity .

HY-E70400

Thermostable T7 RNA Polymerase	DNA/RNA Synthesis	Others
Thermostable T7 RNA Polymerase is a thermostable version of T7 RNA Polymerase (HY-E70090). Compared with T7 RNA Polymerase, it has high temperature resistance and stable activity. T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg ²⁺, T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter .

HY-W419570

(Rac)-BX 048	P2Y Receptor	Cardiovascular Disease
(Rac)-BX 048 is a BX 048 racemate. BX 048 is a P2Y12 receptor antagonist. BX 048 inhibits ADP-induced platelet aggregation in human, dog and rat whole blood. BX 048 also inhibits Arachidonic acid (HY-109590) induced platelet aggregation (IC₅₀ of 15 μM) .

HY-15197

ABT-046	Acyltransferase	Metabolic Disease
ABT-046 is a potent, selective, and orally active acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC₅₀s of both 8 nM against human and mouse DGAT-1 .

HY-P1139

Cortistatin-8 PCFWKTCK	GHSR	Metabolic Disease
Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals .

HY-A0096

Iloprost 4 Publications Verification Ciloprost; ZK 36374	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-A0096R

Iloprost (Standard)	Prostaglandin Receptor Endogenous Metabolite	Endocrinology Cancer
Iloprost (Standard) is the analytical standard of Iloprost. This product is intended for research and analytical applications. Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-N10373

Caffeoyl alcohol	Others	Others
Caffeoyl alcohol is a monomer constituting Catechyl lignin. Catechyl lignin is a linear homopolymer of caffeyl alcohol, a natural source of carbon fiber and high-value chemicals .

HY-162812

H3R antagonist 4	Apoptosis Cholinesterase (ChE) Tau Protein Ferroptosis Histamine Receptor	Neurological Disease
H3R antagonist 4 (compound 11L) was a dual inhibitor of cholinesterase and histamine receptor (H3R), with corresponding IC₅₀ of 7.04 μM (eeAChE), 9.73 μM (hAChE)(reversible) and 1.09 nM (H3R) , respectively. H3R antagonist 4 inhibited the aggregation of Aβ_1-42 induced by itself and Cu ²⁺ (95.48% and 88.63%) , and degraded the Aβ_1-42 fibrils induced by itself and Cu ²⁺ (80.16% and 89.30%) . H3R antagonist 4 chelate biometals such as Cu ²⁺, Zn ²⁺, Al ³⁺, and Fe ²⁺. H3R antagonist 4 significantly reduced tau protein hyperphosphorylation induced by Aβ_1-42 and inhibited RSL-3-induced apoptosis and ferroptosis in PC12 cells. H3R antagonist 4 had the best blood-brain barrier permeability and intestinal absorption in hCMEC/D3 and hPepT1-MDCK cells.H3R antagonist 4 ameliorates learning and memory impairment in a mouse model of Alzheimer's disease induced by scopolamine (HY-N0296) .

HY-155239

VEGFR-2-IN-35	VEGFR	Cancer
VEGFR-2-IN-35 (compound 7) is a potent VEGFR-2 inhibitor with IC₅₀=37 nM. VEGFR-2-IN-35 inhibits MCF-7 and HCT 116 cancer cells with IC₅₀ values of 10.56 and 7.07 μM, respectively .

HY-156261

Beef extract	Biochemical Assay Reagents	Others
Beef extract is a common ingredient in the preparation of biological culture media .

HY-16750

Radalbuvir GS-9669	HCV	Infection
Radalbuvir (GS-9669) is a non-nucleoside inhibitor of nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp). Radalbuvir shows strong anti-HCV potency (GT1a intrinsic EC₅₀ = 2.9 nM, GT1b EC₅₀ = 6 nM) .

HY-119893

Diamfenetide	Parasite	Infection
Diamfenetide is used for the study of Fasciola hepatica infections in vitro. Diamfenetide leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica .

HY-D1451

PKH 26 10+ Cited Publications	Fluorescent Dye	Others
PKH 26 is a red fluorescent dye, PKH 26 can stably bind to the lipid region of cell membrane and emit red fluorescence (Ex/Em=551/567 nm), which is mainly used for in vitro cell labeling, in vitro cell proliferation studies and in vivo and in vitro cell tracing studies .

HY-119893R

Diamfenetide (Standard)	Parasite	Infection
Diamfenetide (Standard) is the analytical standard of Diamfenetide. This product is intended for research and analytical applications. Diamfenetide is used for the study of Fasciola hepatica infections in vitro.?Diamfenetide?leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica .

HY-G0003R

Iloperidone metabolite Hydroxy Iloperidone (Standard)	Drug Metabolite	Others
Diamfenetide (Standard) is the analytical standard of Diamfenetide. This product is intended for research and analytical applications. Diamfenetide is used for the study of Fasciola hepatica infections in vitro.?Diamfenetide?leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica .

HY-101631

Levophacetoperane hydrochloride	Dopamine Transporter	Neurological Disease
Levophacetoperane inhibits in vitro in a competitive manner, norepinephrin uptake and dopamine uptake.

HY-19735

KJ Pyr 9 5+ Cited Publications	c-Myc Autophagy	Cancer
KJ Pyr 9 is an inhibitor of MYC with a K_d of 6.5 nM in in vitro assay.

HY-W796158

Z-DEVD-CMK	Cathepsin	Inflammation/Immunology
Z-DEVD-CMK is an irreversible inhibitor of most of the cathepsins in vitro .

HY-121374

Cardanol diene	Tyrosinase	Infection
Cardanol diene is a phenol found in cashew nut shell liquid that inhibits tyrosinase with an IC₅₀ value of 52.5 μM in vitro.1 Cardanol diene is also used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.

HY-B1207S

Urethane-d5 Ethyl carbamate-d₅; Carbamic acid ethyl ester-d₅; Ethylurethane-d₅	Bacterial Parasite	Infection Neurological Disease Cancer
Urethane-d₅ is the deuterium labeled Urethane. Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro[1].

HY-156615

Igermetostat	Histone Methyltransferase	Cancer
Igermetostat is EZH2 inhibitor, used in cancer research in vivo and in vitro .

HY-142052

Anhydrotetracycline 5a(6)-Anhydrotetracycline	Antibiotic	Infection
Anhydrotetracycline shows dose-dependent and potent inhibition of tetracycline destructases in vitro .

HY-100236

Madrasin 4 Publications Verification DDD00107587	DNA/RNA Synthesis	Cancer
Madrasin (DDD00107587) is a splicing inhibitor that prevents formation of both splicing intermediates and products in vitro and interferes with one or more early steps in the pathway of spliceosome assembly. Madrasin also can inhibit pre-mRNA splicing in vitro and modify splicing of endogenous pre-mRNA in cells .

HY-B0108

Daptomycin 15+ Cited Publications LY146032	Bacterial Antibiotic	Infection Cancer
Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.

HY-N0077

Ginkgolic Acid 5+ Cited Publications Ginkgolic acid (15:1); Ginkgolic acid I; Romanicardic acid	E1/E2/E3 Enzyme	Cancer
Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC₅₀ of 3.0 μM in in vitro assay.

HY-N1213

Sprengerinin C	Others	Cancer
Sprengerinin is a potential angiogenesis inhibitor. Sprengerinin exerts anti-tumorigenic effects in vitro .

HY-N13890

Arginomycin	Antibiotic Bacterial Fungal	Infection
Arginomycin is a nucleoside antibiotic that inhibits the growth of Gram-positive bacteria and fungi in vitro .

HY-N12296

Ciwujianoside C4	Lipase	Metabolic Disease
Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N13883

Aerocavin	Antibiotic Bacterial	Infection
Aerocavin is an antibiotic that is active against both Gram-positive and Gram-negative bacteria in vitro .

HY-156998

Troxacitabine triphosphate TRX-TP	Nucleoside Antimetabolite/Analog	Cancer
Troxacitabine triphosphate (TRX-TP) is a good substrate for replicative and repair DNA polymerases in vitro .

HY-135214

GA11	Aldehyde Dehydrogenase (ALDH)	Cancer
GA11 is an ALDH inhibitor that shows activity against glioblastoma both in vitro and in vivo .

HY-125979

TSPC	Phytohormone	Others
TSPC is a phytohormone gibberellin (GA) perception inhibitor with an IC₅₀ value of 10 μM in vitro .

HY-N12294

Ciwujianoside D2	Lipase	Metabolic Disease
Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-115721

Antimalarial agent 2	Parasite	Infection
Antimalarial agent 2 is a novel orally efficacious antimalarials that suggests a fast in vitro killing profile.

HY-148294

Monogalactosyl diglyceride	Bacterial Fungal	Infection
Monogalactosyl diglyceride is a antimicrobial. Monogalactosyl diglyceride has antibacterial activity and antifungal activity in vitro .

HY-N11707

Piscidic acid	Others	Others
Piscidic acid is an ester compound derived from Cimicifuga racemosa. Piscidic acid has in vitro estrogen activity .

HY-19147

BMY-43748	Bacterial	Infection
BMY-43748 is a promising antibacterial agent, exhibiting great in vitro and in vivo antibacterial activity.

HY-15878

LDC000067 5+ Cited Publications LDC067	CDK Apoptosis	Cancer
LDC000067 is a highly specific CDK9 inhibitor with an IC₅₀ value of 44±10 nM in vitro.

HY-165117

Bactobolamine	Others	Others
Bactobolamine is an immunosuppressive compound that has synergistic activity with cyclosporine in inhibiting allogeneic lymphocyte activation in vitro.

HY-113432S

Nudifloramide-d3	Endogenous Metabolite PARP	Metabolic Disease
Nudifloramide-d₃ (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0096

Iloprost 4 Publications Verification Ciloprost; ZK 36374	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Endocrinology Cancer	Prostaglandin Receptor Endogenous Metabolite
Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-N10373

Caffeoyl alcohol	Structural Classification Leguminosae Source classification Phenols Polyphenols Plants Medicago sativa L.	Others
Caffeoyl alcohol is a monomer constituting Catechyl lignin. Catechyl lignin is a linear homopolymer of caffeyl alcohol, a natural source of carbon fiber and high-value chemicals .

HY-B0108

Daptomycin 15+ Cited Publications LY146032	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Mammalian Cell Culture Antibacterial Disease Research Disease Research Fields	Bacterial Antibiotic
Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.

HY-N0077

Ginkgolic Acid 5+ Cited Publications Ginkgolic acid (15:1); Ginkgolic acid I; Romanicardic acid	Structural Classification Monophenols Ginkgoaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Plants Ginkgo biloba Disease Research Fields Cancer	E1/E2/E3 Enzyme
Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC₅₀ of 3.0 μM in in vitro assay.

HY-N13139

Dexylosyltubeimoside Ⅲ	Triterpenes Structural Classification Actinostemma tenerum Griff. Terpenoids Source classification Cucurbitaceae Plants	Others
Dexylosyltubeimoside Ⅲ (compound 3) is a cyclic disoside that can be isolated from Actinostemma lobatum MAXIM. Dexylosyltubeimoside Ⅲ has in vitro anticancer activity and inhibits the growth of human esophageal cancer cell line ECA109 (IC50=22.37 μM), lung cancer cell line A549 (IC50=27.27 μM) and gastric cancer cell line MGC-803 (IC50=36.85 μM) .

HY-A0096R

Iloprost (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Prostaglandin Receptor Endogenous Metabolite
Iloprost (Standard) is the analytical standard of Iloprost. This product is intended for research and analytical applications. Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-N1213

Sprengerinin C	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Liliaceae Cardiacglycosides Source classification Plants Steroids	Others
Sprengerinin is a potential angiogenesis inhibitor. Sprengerinin exerts anti-tumorigenic effects in vitro .

HY-N13890

Arginomycin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Fungal
Arginomycin is a nucleoside antibiotic that inhibits the growth of Gram-positive bacteria and fungi in vitro .

HY-N12296

Ciwujianoside C4	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Lipase
Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N13883

Aerocavin	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Aerocavin is an antibiotic that is active against both Gram-positive and Gram-negative bacteria in vitro .

HY-N12294

Ciwujianoside D2	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Lipase
Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N11707

Piscidic acid	Structural Classification Cactaceae Ketones, Aldehydes, Acids Source classification Opuntia ficus-indica (L.) Mill. Plants	Others
Piscidic acid is an ester compound derived from Cimicifuga racemosa. Piscidic acid has in vitro estrogen activity .

HY-113242

5-Nonadecylresorcinol	Structural Classification Agrostidoideae Source classification Phenols Polyphenols Plants Triticum aestivum L.	Glycosidase
5-Nonadecylresorcinol is an alkylresorcinol and has inhibitory effects on the release of β-hexosaminidase in vitro .

HY-N2297

Kaji-ichigoside F1	Infection Triterpenes Structural Classification Classification of Application Fields Sanguisorba officinalis Linn. Terpenoids Source classification Rosaceae Plants Disease Research Fields	Antibiotic
Kaji-ichigoside F1 is isolated from S. cuneata with hemolytic and in vitro antiviral activity.

HY-N10920

Genkwanol C	Structural Classification Flavonoids Thymelaeaceae Source classification Plants Biflavones Wikstroemia indica	RSV
Genkwanol C, a biflavonoid, has effective antiviral activity against respiratory syncytial virus (RSV) in vitro .

HY-N2938

Biorobin Kaempferol 3-O-robinobioside	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Euphorbiaceae Plants Acaly phaindica L. Disease Research Fields Cancer	Others
Biorobin (Kaempferol 3-O-robinobioside), a flavonoid, significantly inhibits the human lymphocyte proliferation in vitro .

HY-N2626

Epimedoside A	Infection Flavonols Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields	Others
Epimedoside A is a flavonoid isolated from the roots of Epimedium wushanense. Epimedoside A exhibits significant antioxidant activity in vitro .

HY-N3709

Dehydrocrebanine	Structural Classification Alkaloids Stephania venosa Source classification Plants Isoquinoline Alkaloids Menispermaceae	Others
Dehydrocrebanine is an alkaloid that can be isolated from the tuber and leaves of Stephania venosa. Dehydrocrebanine has in vitro anti-cancer activity .

HY-125060

Viridicatin	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Quinoline Alkaloids Disease Research Fields	Antibiotic Endogenous Metabolite
Viridicatin is a fungal metabolite from Penicillium species. Viridicatin shows slight in vitro antibiotic activity against Mycobacterium tuberculosis .

HY-N1323

Sanggenol P	Structural Classification Flavonoids Flavonones Source classification Plants Moraceae Morus alba Linn.	HBV
Sanggenol P, a flavonoid, shows anti-HBV activity on HepG2.2.15 cell line in vitro .

HY-N1343

Robustine	Alkaloids Monophenols other families Classification of Application Fields Source classification Phenols Quinoline Alkaloids Plants Disease Research Fields Inflammation/Immunology	Phosphodiesterase (PDE)
Robustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro .

HY-N10928

Lettowienolide	Quinones Structural Classification Stellaria media (L.) Villars Source classification Phenols Benzene Quinones Plants Caryophyllaceae	Parasite
Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC₅₀~20 μg/mL) .

HY-122807

Quadrone (-)-Quadrone	Microorganisms Source classification	Others
Quadrone is a sesquiterpene originally isolated from A. terreus. It is cytotoxic to human carcinoma KB cells in vitro (EC₅₀=1.3 μg/mL).

HY-N8400

Roridin L2	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease Research Fields	Endogenous Metabolite
Roridin L2, a fungal metabolite, is a biosynthetic precursor of Satratoxin G. Roridin L2 possesses little in vitro or in vivo toxic activity .

HY-N12297

Ciwujianoside C2	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Lipase
Ciwujianoside C2 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C2 enhances pancreatic lipase activity in vitro .

HY-N5007

Galgravin	Structural Classification Classification of Application Fields Magnoliaceae Source classification Lignans Magnolia Liliflora Desr. Phenylpropanoids Plants Disease Research Fields Cancer	Apoptosis
Galgravin is an active compound in Nectandra megapotamica, with anti-inflammatory activity. Galgravin displays in vitro cytotoxic activity and induce apoptosis in leukemia cells .

HY-N6940

Prosapogenin A Progenin III	Structural Classification Veratrum nigrum Linn. other families Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Apoptosis
Prosapogenin A, a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis .

HY-N10204

Rostratin B	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Endogenous Metabolite
Rostratin B, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC₅₀ of 1.9 μg/mL .

HY-N9317

Tangshenoside I	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Campanulaceae Metabolic Disease Codonopsis lanceolata (Sieb. et Zucc.) Trautv. Plants Disease Research Fields	Glycosidase
Tangshenoside I, isolated from the roots of Codonopsis lanceolata, exhibits weak α-glucosidase inhibitory activities in vitro with an IC₅₀ of 1.4 mM .

HY-N12298

Ciwujianoside C1	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Lipase
Ciwujianoside C1 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C1 inhibits pancreatic lipase activity in vitro .

HY-N7798

Pennogenin	Structural Classification Natural Products Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
Pennogenin is a bioactive component which can be isolated from T. govanianum rhizomes. Pennogenin exhibits significant in vitro inhibitory effect on release of ROS .

HY-N7454

Anhydroerythromycin A	Infection Structural Classification Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Endogenous metabolite Disease Research Fields	Antibiotic Bacterial
Anhydroerythromycin A is a degradation product of the macrolide antibiotic erythromycin. Anhydroerythromycin A is formed via degradation of erythromycin in acidic aqueous solutions in vitro as well as in vivo. Anhydroerythromycin A is active against S. aureus and B. cereus in vitro (MICs = 12.5 and 6.25 μg/ml, respectively). Anhydroerythromycin A also inhibits steroid 6β-hydroxylase activity associated with the cytochrome P450 (CYP) isoform CYP3A in human liver microsomes.

HY-111815

N4-Acetylcytidine triphosphate ac4CTP	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N4-Acetylcytidine triphosphate is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and can be incorporated into multiple templates .

HY-119529

Jineol 3,8-Quinolinediol	Alkaloids Animals Classification of Application Fields Source classification Quinoline Alkaloids Disease Research Fields Cancer	Tyrosinase Bacterial
Jineol is a cytotoxic alkaloid from the centipede Scolopendra subspinipes. Jineol exhibits modest cytotoxic activity in vitro against the growth of human tumor cell lines .

HY-111815A

N4-Acetylcytidine triphosphate sodium 1 Publications Verification ac4CTP sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and it can be incorporated into multiple templates .

HY-117845

Citreamicin alpha LL-E19085α	Structural Classification Microorganisms Antibiotics Source classification	Bacterial Antibiotic
Citreamicin alpha (LL-E 19085-alpha) is an antibiotic whose in vitro antimicrobial activity against 429 clinical isolates of Gram-positive cocci has been tested by the agar dilution method. These microorganisms included 313 strains of Staphylococci and 116 strains of Streptococci. The in vitro activity of Citreamicin alpha was compared with that of ampicillin, amoxicillin, ceftriaxone, erythromycin, and vancomycin. For Staphylococci, the MIC values of Citreamicin alpha ranged from 0.12-4.0 μg/ml, and for Streptococcus pyogenes of the genus Streptococcus, it was 0.03-0.12 μg/ml. However, enterococci were relatively resistant, requiring 2.0 μg/ml of the agent to inhibit 64% of the 62 tested strains. The in vitro activity of this antibiotic was much better than that of ampicillin, amoxicillin, ceftriaxone, and erythromycin, but comparable or slightly inferior to that of vancomycin.

HY-N8394

Eupatolide	Source classification Plants Compositae Guilandina minax (Hance) G. P. Lewis	Others
Eupatolide is an antitumor agent that can be isolated from Eupatorium formosanum. Eupatolide has cytotoxic activity and inhibits human epidermoid carcinoma of larynx cell growth in vitro .

HY-N11777

(−)-N-Hydroxyapiosporamide NHAP	Structural Classification Alkaloids Microorganisms Source classification Pyridine Alkaloids	NF-κB
(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, is an NF-κB inhibitor with potent antitumor activity in vitro and in vivo. (−)-N-Hydroxyapiosporamide can be used for the research of colorectal cancer (CRC) .

HY-N0077R

Ginkgolic Acid (Standard)	Structural Classification Monophenols Ginkgoaceae Ketones, Aldehydes, Acids Source classification Phenols Plants Ginkgo biloba	E1/E2/E3 Enzyme
Ginkgolic Acid (Standard) is the analytical standard of Ginkgolic Acid. This product is intended for research and analytical applications. Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC50 of 3.0 μM in in vitro assay.

HY-N7314

Asebogenin	Structural Classification Populus balsamifera L. Source classification Phenols Polyphenols Plants Salicaceae	Syk
Asebogenin has antimalarial activity in vitro . Asebogenin can inhibit the phosphorylation of Syk, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps .

HY-N2442

Methylophiopogonone B	Structural Classification Natural Products other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Reactive Oxygen Species
Methylophiopogonone B, a homoisoflavonoidal compound that could be isolated from Ophiopogonis Tiber, could scavenge •OH and H₂O₂ in vitro to a certain extent .

HY-N14092

Chuangxinmycin	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
Chuangxinmycin is an antibiotic that can be isolated from Actinoplanes tsinanensis CPCC 200056. Chuangxinmycin exhibits both in vitro and in vivo antibacterial activities and can be utilized in infection research .

HY-N10205

Rostratin C	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Endogenous Metabolite
Rostratin C, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC₅₀ value of 0.76μg /mL .

HY-N12654

Irumamycin	Structural Classification Microorganisms Antibiotics Source classification	Fungal Parasite Antibiotic
Irumamycin is a natural 20-membered macrolide antibiotic. Irumamycin is active in vitro against some phytopathogenic fungi . Irumamycin also shows potent antitrypanosomal activity .

HY-101414

L-DABA 1 Publications Verification L-2,4-Diaminobutyric acid	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	GABA Receptor Endogenous Metabolite
L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC₅₀ of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

HY-128366

Waltonitone	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo .

HY-123638

6-Hydroxykaempferol 3,6,7-tri-O-β-D-glucoside	Structural Classification Flavonoids Carthamus tinctorius L. Flavonones Source classification Plants Compositae	Drug Intermediate
6-hydroxykaempferol 3,6,7-tri-O-β-D-glucoside is a bio-active flavonoid from Carthamus tinctorius with antioxidant capacities in vitro .

HY-N12362

Antiviral agent 41	Structural Classification Monophenols Source classification Phenols Alpinia officinarum Hance Plants Zingiberaceae	Influenza Virus
Antiviral agent 41 (compound 5) is a diarylheptanoid isolated from Alpinia officinarum. Antiviral agent 41 exhibits potential antiviral activity against influenza virus in vitro .

HY-129071

Vindesine sulfate	Apocynaceae Structural Classification Piperidine Alkaloids Pyrrole Alkaloids Source classification Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don Cancer	Microtubule/Tubulin
Vindesine sulfate is a potent tubulin inhibitor with an K_i of 0.110 µM. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo .

HY-113008B

trans-Urocanic acid (E)-Urocanic acid; trans-UCA	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function .

Cat. No.	Product Name	Chemical Structure

HY-B1207S

Urethane-d5
Urethane-d₅ is the deuterium labeled Urethane. Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro[1].

HY-113432S

Nudifloramide-d3
Nudifloramide-d₃ (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].

HY-B0282S1

Acetylcholine-d9 chloride

Acetylcholine-d₉ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-B0282S

Acetylcholine-d4 chloride

Acetylcholine-d₄ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

HY-W031727S

Hydroxychloroquine-d4-1 sulfate
Hydroxychloroquine-d₄-1 (sulfate) is the deuterium labeled Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

HY-Y0378S

D-Leucine-d10
D-Leucine-d₁₀ is the deuterium labeled D-Leucine. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].

HY-104077S

Remdesivir-d5 2 Publications Verification
Remdesivir-d₅ is a deuterium labeled Remdesivir. Remdesivir (GS-5734) is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of 2019-nCoV (COVID-19) infection in vitro[1][2].

HY-W031727S1

Hydroxychloroquine-d5
Hydroxychloroquine-d₅ is the deuterium labeled Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].

HY-B1370S

Hydroxychloroquine-d4 sulfate
Hydroxychloroquine-d₄ (sulfate) is the deuterium labeled Hydroxychloroquine sulfate. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

HY-104077S1

Remdesivir-d4
Remdesivir-d₄ is deuterium labeled Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].

HY-104077S2

Remdesivir impurity 9-d4
Remdesivir impurity 9-d₄ is deuterium labeled Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].

HY-14667S

Lomitapide-d8
Lomitapide-d₈ is deuterium labeled Lomitapide. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.

HY-13637S

Ganciclovir-d5

Ganciclovir-d₅ is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3].

HY-13683S

Mifepristone-d3
Mifepristone-d₃ is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].

HY-19581S

Baquiloprim-d6
Baquiloprim-d₆ is deuterium labeled Baquiloprim. Baquiloprim, an antibiotic, is a selective inhibitor of bacterial dihydrofolate reductases. Baquiloprim possesses in vitro bacteriostatic activity against both Gram-negative and Gram-positive bacteria[1][2].

HY-13683S2

Mifepristone-d6
Mifepristone-d₆ is deuterated labeled Mifepristone (HY-13683). Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC₅₀s of 0.2 nM and 2.6 nM in in vitro assay .

HY-N0091S1

Hypoxanthine-13C,15N2
Hypoxanthine- ¹³C, ¹⁵N₂ is a ¹⁵N-labeled and ¹³C-labled Furaltadone. Furaltadone, a nitrofuran agent, has the potential for the study in infections of chickens with salmonella enteritidis. Furaltadone is inhibitory and bactericidal in vitro for staphylococci

HY-16985S

Darolutamide-d4
Darolutamide-d₄ (ODM-201-d₄) is deuterium labeled Darolutamide. Darolutamide (ODM-201;BAY-1841788) is a potent androgen receptor (AR) antagonist with an IC₅₀ of 26 nM in in vitro assay .

HY-16305S

Maribavir-d6
Maribavir-d₆ (1263W94-d₆) is a deuterium labeled Maribavir (HY-16305). Maribavir is a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, with an IC₅₀ of 3 nM .

HY-B1057S1

Nefopam-d4 hydrochloride
Nefopam-d₄ (hydrochloride) is deuterium labeled Nefopam (hydrochloride). Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo[1][2].

HY-B1057S

Nefopam-d3 hydrochloride
Nefopam-d₃ (hydrochloride) is the deuterium labeled Nefopam hydrochloride. Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo[1][2].

HY-12766S

Bupropion morpholinol-d6
Bupropion morpholinol-d6 is the deuterated form of Bupropion morpholinol. Bupropion morpholinol is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities .

HY-19822S2

Elacestrant-d10
Elacestrant-d₁₀ is the deuterium labeled of Elacestrant (HY-19822). Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also inhibits growth of ER ⁺ breast cancer cell lines in vitro and in vivo .

HY-107116S

MAP4343-d4
MAP4343-d₄ is the deuterium labeled MAP4343. MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2][3].

HY-14806S1

Teneligliptin-d4
Teneligliptin-d₄ is deuterium labeled Teneligliptin. Teneligliptin (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor. Teneligliptin competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM[1].

HY-B1462S

Chlorzoxazone-d3
Chlorzoxazone-d₃ is the deuterium labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans.

HY-10917S

GW2580-d6
GW2580-d6 is the deuterium labeled GW2580. GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling .

HY-15660S

Efinaconazole-d4
Efinaconazole-d₄ is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively[1]. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species[1].

HY-17589S1

Chloroquine-d4 phosphate

Chloroquine-d₄ (phosphate) is the deuterium labeled Chloroquine phosphate. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17589S

Chloroquine-d5 diphosphate

Chloroquine-d₅ (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-19822S3

Elacestrant-d6
Elacestrant-d₆ (RAD1901-d₆) is a deuterated labeled Elacestrant (HY-19822). Elacestrant is a selective estrogen receptor (estrogen receptor, ER) degrader (SERD) with oral activity, with IC₅₀ values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant can also effectively inhibit the growth of ER ⁺ breast cancer cell lines both in vitro and in vivo.

HY-14904AS

Umifenovir-d6 hydrochloride

Umifenovir-d₆ (hydrochloride) is the deuterium labeled Umifenovir hydrochloride. Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity[3].

HY-17589AS

Chloroquine-d5 1 Publications Verification
Chloroquine-d₅ is deuterium labeled Chloroquine (HY-17589A). Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

HY-W011834S

2'-O-Methylcytidine-d3
2'-O-Methylcytidine-d₃ is deuterium labeled 2'-O-Methylcytidine (HY-W011834). 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.

HY-19822S

Elacestrant-d4
Elacestrant-d₄ (RAD1901-d₄) is a deuterated labeled Elacestrant (HY-19822). Elacestrant (RAD1901) is a selective estrogen receptor (estrogen receptor, ER) degrader (SERD) with oral activity, with IC₅₀ values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant can also effectively inhibit the growth of ER ⁺ breast cancer cell lines both in vitro and in vivo.

HY-13683S1

Mifepristone-13C,d3

Mifepristone- ¹³C,d₃ is the ¹³C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N6703S

ar-Turmerone-d3

ar-Turmerone-d₃ is the deuterium labeled ar-Turmerone. ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .

HY-138253S

2′,2′-Difluorodeoxyuridine-13C,15N2

2′,2′-Difluorodeoxyuridine- ¹³C, ¹⁵N₂ (dFdU- ¹³C, ¹⁵N₂) is a ¹³C- and ¹⁵N-labeled compound. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells .

HY-15303S

Pritelivir-d4-1
Pritelivir-d₄-1 (AIC316-d₄-1) is deuterium labeled Pritelivir. Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC₅₀ of 0.02 μM against HSV1-2 .

HY-B1118S2

Secnidazole-d4

Secnidazole-d₄ is the deuterium labeled Secnidazole[1]. Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis[1][2][3].

HY-110228

Metformin-d6 hydrochloride

Metformin-d₆ hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

HY-B0523S

Anagrelide-13C2,15N,d2

Anagrelide- ¹³C₂, ¹⁵N,d₂ is ¹⁵N and deuterated labeled Anagrelide (HY-B0523). Anagrelide is a potent inhibitor of phosphodiesterase type III (PDE3) (IC₅₀=36 nM). Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide inhibits bone marrow megakaryocytopoiesis. Anagrelide decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide is a platelet-lowering agent and plays in the antithrombopoietic action .

HY-17623S

Tegoprazan-d6

Tegoprazan (CJ-12420; RQ-00000004), a potassium-competitive acid blocker, is a reversible, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC₅₀ values ranging from 0.29-0.52 μM for porcine, canine, and human H ⁺/K ⁺-ATPases in vitro. Tegoprazan significantly improves colitis in mice and enhances the intestinal epithelial barrier function. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases .

HY-W014839S

Cyclamic acid-d11 sodium

Cyclamic acid-d₁₁ (Sodium cyclamate-d₁₁) sodiumis deuterium labeled Cyclamic acid (sodium). Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine .

HY-B1234S

Octinoxate-13C,d3

Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

HY-123489S

3α,21-Dihydroxy-5α-pregnan-20-one-d3
3α,21-Dihydroxy-5α-pregnan-20-one-d₃ is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.

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