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CD36 and LIMPII analogous 1 (CLA-1)

" in MedChemExpress (MCE) Product Catalog:

2299

Inhibitors & Agonists

3

Screening Libraries

15

Fluorescent Dye

190

Biochemical Assay Reagents

1536

Peptides

30

Inhibitory Antibodies

148

Natural
Products

309

Recombinant Proteins

10

Isotope-Labeled Compounds

78

Antibodies

21

Click Chemistry

110

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-163649
    A17

    		AMPK Metabolic Disease
    A17 is a bile acid analog with anti-non-alcoholic steatohepatitis (NASH) and anti-inflammatory activities. A17 reduces fatty acid (FA) uptake and promotes FA oxidation though inhibiting fatty acid translocase (Cd36) expression and activating AMPKα. A17 can be used for NASH research [1].
    A17
  • HY-163541
    SMS121

    		Scavenger Receptor Class B type I (SR-BI） Cancer
    SMS121 is a CD36 inhibitor with a KD values of about 5 µM. SMS121 reduces the uptake of lipids and inhibits cell viability in acute myeloid leukemia cells. SMS121 has antitumor activity [1].
    SMS121
  • HY-128671
    6-​Thioinosine

    6TI; 6-Mercaptopurine riboside

    		 Nucleoside Antimetabolite/Analog Metabolic Disease
    6-​Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα [1] .
    6-​Thioinosine
  • HY-P10184
    CD36 Peptide P (93-110), Cys conjugated

    		Transmembrane Glycoprotein Inflammation/Immunology
    CD36 Peptide P (93-110), Cys conjugated is a Cys labelled CD36 Peptide, and can block binding of CD36 to immobilized thrombospondin and partially inhibited collagen-induced platelet aggregation [1].
    CD36 Peptide P (93-110), Cys conjugated
  • HY-P10183
    CD36 Peptide P (139-155), Cys conjugated

    Cys-CD36(139-155)

    		 Transmembrane Glycoprotein Inflammation/Immunology
    CD36 Peptide P (139-155), Cys conjugated is a Cys labelled CD36 Peptide, and can inhibit the immunoadsorption of CD36 by OKM5 [1].
    CD36 Peptide P (139-155), Cys conjugated
  • HY-RS02237
    CD36 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CD36 Human Pre-designed siRNA Set A contains three designed siRNAs for CD36 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CD36 Human Pre-designed siRNA Set A
    CD36 Human Pre-designed siRNA Set A
  • HY-RS16502
    Cd36 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA)
    Cd36 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd36 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Cd36 Mouse Pre-designed siRNA Set A
    Cd36 Mouse Pre-designed siRNA Set A
  • HY-P990352
    Anti-CD36 Antibody

    		Scavenger Receptor Class B type I (SR-BI） Inflammation/Immunology
    Anti-CD36 Antibody is a humanized antibody expressed in CHO that targets CD36. The Anti-CD36 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CD36 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CD36 Antibody
  • HY-125554
    KDdiA-PC

    		Transmembrane Glycoprotein Cardiovascular Disease
    KDdiA-PC is one of the most potent CD36 ligands in oxidized LDL (oxLDL) [1].
    KDdiA-PC
  • HY-154857
    1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine

    		Scavenger Receptor Class B type I (SR-BI） Cancer
    1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine is a glycerophosphorylcholine, consisting of glycerol phosphate, choline and palmitic acid. It accumulates in vivo at sites of oxidative stress. 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine may be a ligand of scavenger receptors class B, while oxidized phospholipids oxPC(CD36) are potent ligands of scavenger receptors class B (CD36 and SR-BI). Oxidized phospholipids (oxPLs) also play an important role in tumor apoptosis, may be elevated in malignant biliary strictures [1] .
    1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine
  • HY-112847A
    Sulfosuccinimidyl oleate sodium
    Maximum Cited Publications
    26 Publications Verification

    Sulfo-N-succinimidyl oleate sodium

    		 Mitophagy Inflammation/Immunology
    Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect [1] .
    Sulfosuccinimidyl oleate sodium
  • HY-112847
    Sulfosuccinimidyl oleate

    Sulfo-N-succinimidyl oleate

    		 Mitophagy Inflammation/Immunology
    Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect [1] .
    Sulfosuccinimidyl oleate
  • HY-126726
    KOdiA-PC

    		Biochemical Assay Reagents Others
    Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species that are cytotoxic and proatherogenic. Many of these species were recently isolated and purified from oxLDL and identified as phosphatidylcholine species containing fragmented oxidized short-chain fatty acid residues at the sn-2 position. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl)phosphatidylcholine or KOdiA-PC is one of the most potent CD36 ligands of the oxLDL species. KOdiA-PC confers CD36 scavenger receptor binding affinity to LDL at a frequency of only 2 to 3 KOdiA-PC molecules/LDL particle and may be one of the more important structural determinants of oxLDL.
    KOdiA-PC
  • HY-P3970
    KRFK

    		TGF-β Receptor Inflammation/Immunology
    KRFK, a peptide derived from TSP-1, can activate TGF-β. KRFK promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK can be used for chronic ocular surface inflammatory disorders reseach [1].
    KRFK
  • HY-P3970A
    KRFK TFA
    2 Publications Verification

    		 TGF-β Receptor Inflammation/Immunology
    KRFK TFA, a peptide derived from TSP-1, can activate TGF-β. KRFK TFA promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK TFA can be used for chronic ocular surface inflammatory disorders reseach [1].
    KRFK TFA
  • HY-116003
    12,13-DiHOME

    		Endogenous Metabolite Metabolic Disease
    12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders [1].
    12,13-DiHOME
  • HY-112847B
    (E/Z)-Sulfosuccinimidyl oleate sodium

    (E/Z)-Sulfo-N-succinimidyl oleate sodium

    		 Mitophagy Inflammation/Immunology
    (E/Z)-Sulfosuccinimidyl oleate sodium is a racemic compound of (Z)-Sulfosuccinimidyl oleate sodium and (Z)-Sulfosuccinimidyl oleate sodium isomers. Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds the CD36 receptor on the surface of microglia. Sulfosuccinimidyl oleate sodium has anti-inflammatory effect [1] .
    (E/Z)-Sulfosuccinimidyl oleate sodium
  • HY-168371
    1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC

    		Scavenger Receptor Class B type I (SR-BI） Metabolic Disease
    1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC (13-HODE-PC) is an oxidized phospholipid that contains Palmitic acid (HY-N0830) and 13(S)-HODE (HY-113884B) at the sn-1 and sn-2 positions, respectively. 1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC has the ability to compete for the binding of 125I-NO2-LDL (5 g/mL) to CD36-transfected 293 cells, with the IC50 of ＞ 200 μM [1].
    1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC
  • HY-155938
    Cyano-myracrylamide

    		Acyltransferase Neurological Disease Inflammation/Immunology Cancer
    Cyano-myracrylamide is an inhibitor of zinc finger DHHC domain-containing palmitoyltransferase 20 (zDHHC20) with an IC50 value of 1.35 µM. Cyano-myracrylamide also inhibits the S-Acylation of EGFR and CD36. Cyano-myracrylamide also inhibits S-acylation of Legionella E3 ligase GobX, MyD88, and Ras, which are substrates of zDHHC20, zDHHC9, and zDHHC6, respectively, in HEK293T cells expressing recombinant Legionella GobX, recombinant human MyD88, or endogenous Ras [1].
    Cyano-myracrylamide
  • HY-168049
    ZLY06

    		PPAR Akt Metabolic Disease
    ZLY06 is an orally active dual agonist of peroxisome proliferator-activated receptor (PPAR) δ and γ (PPAR δ: EC50=341 nM; PPAR γ: EC50=237 nM). ZLY06 induces hepatic lipid accumulation by inhibiting the phosphorylation of AKT1, mediating the upregulation of CD36. In addition, ZLY06 significantly improves glucose and lipid metabolism without increasing body weight, and alleviates fatty liver by promoting β-oxidation of fatty acids and inhibiting hepatic lipogenesis [1] .
    ZLY06
  • HY-P10873
    ST-CY14

    		Nuclear Hormone Receptor 4A/NR4A Mitochondrial Metabolism Cancer
    ST-CY14 is an inhibitor for Nur77-PPARγ interaction with an EC50 of 3.15 μM, that binds to Nur77 (Kd=32 nM), blocks Nur77 from being ubiquitinated and degraded by PPARγ, reduces fatty acid uptake and mitochondrial respiration, and inhibits the transcription of CD36 and FABP4. ST-CY14 inhibits the proliferation and migration of cancer cell MCF7 and MDA-MB-231. ST-CY14 inhibits tumor growth and bone metastasis in mouse models [1].
    ST-CY14
  • HY-P10388
    TAX2 peptide

    		CD47 TGF-β Receptor Cancer
    TAX2 peptide is a dodecapeptide based on molecular docking and simulation design, derived from the cell surface receptor CD47 sequence. TAX2 peptide acts as a selective antagonist of TSP-1 (thromboxin-1) interacting with CD47. TAX2 peptide can promote the binding of TSP-1 to CD36, which leads to the destruction of VEGFR2 (vascular endothelial growth factor receptor 2) activation, thereby blocking downstream NO (nitric oxide) signaling, demonstrating anti-angiogenic properties. TAX2 peptide can be used to study angiogenesis and tumor cell interactions in the tumor microenvironment [1].
    TAX2 peptide
  • HY-134957
    VT107
    5 Publications Verification

    		 YAP Cancer
    VT-107, as an analogous to VT104, is an orally active and potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer [1].
    VT107
  • HY-119404
    Diproqualone

    (±)-Diproqualone

    		 GABA Receptor Neurological Disease Inflammation/Immunology
    diproqualone is methaqualone analogous with sedative, anxiolytic, anti-inflammatory and analgesic properties [1].
    Diproqualone
  • HY-136991
    Basacv

    		Antibiotic Others
    Basacv is a DNA-polyintercalating bifunctional compound with DNA-high affinity. Basacv is structurally analogous to the antibiotic anti-tumour drug Triostin A and act as a bis-intercalator [1].
    Basacv
  • HY-W140555
    5,7-Dimethoxyphthalide

    		Biochemical Assay Reagents Others
    5,7-Dimethoxyphthalide can be conjugated to functionalized long-chain alkyl iodides that are useful in designing a focused mini-library of analogous and congeners of CJ-molecules for SAR study [1].
    5,7-Dimethoxyphthalide
  • HY-129046C
    RNase B, Bovine Pancreas

    Ribonuclease B, Bovine Pancreas

    		 DNA/RNA Synthesis Others
    RNase B, Bovine Pancreas is an N-glycosylated form of bovine pancreatic ribonuclease, which is structurally analogous to RNase A. RNase B, Bovine Pancreas promotes the folding of polypeptide chains and performs a chaperone-like function [1].
    RNase B, Bovine Pancreas
  • HY-P990353
    Anti-CD4 Antibody (TRX1)

    TRX1

    		 Transmembrane Glycoprotein Inflammation/Immunology
    Anti-CD4 Antibody (TRX1) is a humanized antibody expressed in CHO cells that targets CD4. Anti-CD4 Antibody (TRX1) has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-CD4 Antibody (TRX1) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CD4 Antibody (TRX1)
  • HY-P10877
    Bicyclic UK18

    		PAI-1 Cancer
    Bicyclic UK18 is a competitive inhibitor for human urokinase-type plasminogen activator (uPA) with a Ki of 53 nM [1].
    Bicyclic UK18
  • HY-P10878
    UK140

    		PAI-1 Cancer
    UK140 is the inhibitor for urokinase-type plasminogen activator (uPA) with Ki of 0.20 µM and 2.79 µM for huPA anf muPA. UK140 can be used in metastasis-related research [1].
    UK140
  • HY-P4210
    Sulanemadlin

    ALRN-6924; MP-4897

    		 MDM-2/p53 Cancer
    Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research [1].
    Sulanemadlin
  • HY-P5984A
    Thioether-cyclized helix B peptide, CHBP TFA

    		mTOR Others
    Thioether-cyclized helix B peptide, CHBP (TFA) is the TFA form of Thioether-cyclized helix B peptide, CHBP (HY-P5984). Thioether-cyclized helix B peptide, CHBP (TFA) can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 [1].
    Thioether-cyclized helix B peptide, CHBP TFA
  • HY-P5984
    Thioether-cyclized helix B peptide, CHBP

    		mTOR Others
    Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 [1].
    Thioether-cyclized helix B peptide, CHBP
  • HY-P1426
    AmmTX3

    		Potassium Channel Inflammation/Immunology
    AmmTX3 is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 is specific blocker of Kv4 channel. AmmTX3 inhibits the A-type K + current (Ki: 131 nM) [1] .
    AmmTX3
  • HY-P10319
    RI-STAD-2

    		PKA Cardiovascular Disease Cancer
    RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA). RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer [1].
    RI-STAD-2
  • HY-124200
    AL 8810 isopropyl ester

    		Prostaglandin Receptor Endocrinology
    AL 8810 (Item No. 16735) is an 11β-fluoro analog of prostaglandin F2α which acts as a potent and selective antagonist at the FP receptor. AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost (HY-B0577) and Travoprost (HY-B0584).
    AL 8810 isopropyl ester
  • HY-120240
    AND-302

    		Others Others
    AND-302 is a small molecule anticonvulsant with activity in preventing glutamate- or hydrogen peroxide-induced cell death and decreased neuronal viability in in vitro hippocampal cultures.
    AND-302
  • HY-135297
    Mono-and diglycerides

    		Biochemical Assay Reagents Others
    Mono-and diglycerides is formed by triglycerides being broken down by pancreatic lipase in the gastrointestinal lumen. Mono-and diglycerides is a food additive used as a nonionic emulsifier and mainly present in food fats [1] .
    Mono-and diglycerides
  • HY-150184
    And1-IN-1

    		DNA/RNA Synthesis Cancer
    And1-IN-1 (compound III) is a potent And1 inhibitor [1].
    And1-IN-1
  • HY-P2498A
    Cathepsin D and E FRET Substrate acetate

    		Cathepsin Cancer
    Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D [1].
    Cathepsin D and E FRET Substrate acetate
  • HY-112147
    IDO1 and HDAC1 Inhibitor

    		Indoleamine 2,3-Dioxygenase (IDO) HDAC Cancer
    IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC50s of 69.0 nM and 66.5 nM, respectively [1].
    IDO1 and HDAC1 Inhibitor
  • HY-162896
    And1 degrader 1

    		DNA/RNA Synthesis Cancer
    And1 degrader 1 (Compound A15) is a degrader of the acidic nucleoplasmic DNA-binding protein 1 (And1), which can significantly induce the degradation of And1 in NSCLC cells. And1 degrader 1 (5 μM) combined with Olaparib (HY-10162) (1 μM) effectively inhibits the proliferation of A549 and H460 cells. And1 degrader 1 can be used in cancer research [1].
    And1 degrader 1
  • HY-P2498
    Cathepsin D and E FRET Substrate

    		Cathepsin Others
    Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D [1].
    Cathepsin D and E FRET Substrate
  • HY-P1887
    p5 Ligand for Dnak and DnaJ

    		HSP Infection
    p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase. p5 Ligand for Dnak and DnaJ is a high-affinity ligand for DnaK and DnaJ [1].
    p5 Ligand for Dnak and DnaJ
  • HY-146005
    Tau-aggregation and neuroinflammation-IN-1

    		Microtubule/Tubulin Neurological Disease Inflammation/Immunology
    Tau-aggregation and neuroinflammation-IN-1 is a potent tau-aggregation and neuroinflammation inhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reduced NO release in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats [1].
    Tau-aggregation and neuroinflammation-IN-1
  • HY-E70315
    Chimax-G

    Fungal Endo- and Exo- chitosanases

    		 Endogenous Metabolite Others
    Chimax-G (Fungal Endo- and Exo- chitosanases) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1].
    Chimax-G
  • HY-126304A
    Glycerophosphoric acid (disodium salt hydrate) (α and β mixture)
    10+ Cited Publications

    		 Biochemical Assay Reagents Others
    Glycerophosphoric acid (disodium salt hydrate) (α and β mixture) is a complex contains α and β Glycerophosphoric acid isomers.
    Glycerophosphoric acid (disodium salt hydrate) (α and β mixture)
  • HY-70027A
    p53 and MDM2 proteins-interaction-inhibitor dihydrochloride

    		MDM-2/p53 E1/E2/E3 Enzyme Cancer
    p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is an inhibitor of the interaction between p53 and MDM2 proteins.
    p53 and MDM2 proteins-interaction-inhibitor dihydrochloride
  • HY-143497
    HDAC1/2 and CDK2-IN-1

    		HDAC CDK Apoptosis Cancer
    HDAC1/2 and CDK2-IN-1 (compound 14d) is a potent HDAC1, HDAC2 and CDK2 dual inhibitor, with IC50 values of 70.7, 23.1 and 0.80 μM, respectively. HDAC1/2 and CDK2-IN-1 can block the cell cycle and induce apoptosis. HDAC1/2 and CDK2-IN-1 exhibits desirable in vivo antitumor activity [1].
    HDAC1/2 and CDK2-IN-1
  • HY-139637
    (±)-Silybin

    Silibinin (mixture of Silybin A and Silybin B)

    		 Apoptosis Cancer
    (±)-Silybin is the racemate of Silybin (HY-N0779A). Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity [1] .
    (±)-Silybin

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