Search Result

Results for "

KI mice

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (4) 5 alpha Reductase (1) 5-HT Receptor (26) Acyltransferase (1) ADC Cytotoxin (2) Adenosine Deaminase (1) Adenosine Receptor (10) Adrenergic Receptor (11) Akt (18) Aldehyde Dehydrogenase (ALDH) (1) Amine N-methyltransferase (1) Amino Acid Decarboxylase (1) Amino Acid Derivatives (4) Aminopeptidase (4) Aminotransferases (Transaminases) (1) AMPK (12) Amylases (1) Amyloid-β (19) Anaplastic lymphoma kinase (ALK) (7) Androgen Receptor (10) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (3) ANGPTL (1) Antibiotic (53) Antifolate (2) AP-1 (2) Apical Sodium-Dependent Bile Acid Transporter (3) Apolipoprotein (2) Apoptosis (141) Arrestin (2) Aryl Hydrocarbon Receptor (5) Atg7 (1) Atg8/LC3 (2) ATP Synthase (1) Autophagy (40) Bacterial (103) Bcl-2 Family (10) BCRP (3) Beta-secretase (3) Biochemical Assay Reagents (27) Bombesin Receptor (2) Bradykinin Receptor (4) Btk (1) c-Fms (2) c-Kit (1) c-Met/HGFR (3) Calcium Channel (24) Calmodulin (1) CaMK (2) Cannabinoid Receptor (16) Carbonic Anhydrase (1) Casein Kinase (4) Caspase (10) CaSR (3) Cathepsin (3) CCR (1) CD20 (1) CD3 (1) CD38 (2) CDK (11) Ceramidase (2) CFTR (1) Chemerin Receptor (1) Chloride Channel (2) Cholecystokinin Receptor (3) Cholinesterase (ChE) (16) CMV (3) Complement System (4) COMT (1) Constitutive Androstane Receptor (1) COX (5) CRISPR/Cas9 (1) Cuproptosis (1) CXCR (5) Cyclic GMP-AMP Synthase (1) Cytochrome P450 (14) DAGL (1) DAPK (1) Dengue Virus (1) Deubiquitinase (3) DGK (1) Dihydroorotate Dehydrogenase (2) Dipeptidyl Peptidase (4) Discoidin Domain Receptor (1) DNA Methyltransferase (2) DNA/RNA Synthesis (24) Dopamine Receptor (21) Dopamine Transporter (4) Dopamine β-hydroxylase (1) Drug Derivative (17) Drug Intermediate (2) Drug Isomer (5) Drug Metabolite (9) Drug-Linker Conjugates for ADC (2) DYRK (2) E1/E2/E3 Enzyme (5) EAAT (2) EBI2/GPR183 (1) EBV (2) EGFR (13) Endogenous Metabolite (94) Endothelin Receptor (1) Enterovirus (4) Ephrin Receptor (1) Epigenetic Reader Domain (12) Epoxide Hydrolase (2) ERK (13) Estrogen Receptor/ERR (9) Eukaryotic Initiation Factor (eIF) (1) FAAH (1) FABP (2) Factor Xa (1) Factor XI (1) FAK (4) Farnesyl Transferase (2) FATP (1) Fatty Acid Synthase (FASN) (4) Fc Receptor (FcR) (1) Ferroptosis (13) FGFR (3) FKBP (1) FLAP (2) Flavivirus (2) FLT3 (4) Fluorescent Dye (13) FOXO (1) Free Fatty Acid Receptor (2) Fungal (21) FXR (7) G protein-coupled Bile Acid Receptor 1 (1) G Protein-coupled Receptor Kinase (GRK) (1) G-quadruplex (2) GABA Receptor (14) Galectin (1) Gap Junction Protein (2) GCGR (7) GHSR (1) GLP Receptor (9) Glucocorticoid Receptor (1) Glucokinase (1) Glucosylceramide Synthase (GCS) (1) GLUT (1) Glutathione Peroxidase (2) Glutathione S-transferase (4) Glycosidase (8) Glycosyltransferase (1) GlyT (1) GnRH Receptor (4) GPR119 (3) GPR171 (1) GPR35 (1) GPR52 (1) GPR68 (2) GPR88 (1) GSK-3 (5) Guanylate Cyclase (1) HBV (11) HCV (2) HDAC (15) Heme Oxygenase (HO) (1) Herbicide (4) HIF/HIF Prolyl-Hydroxylase (6) Histamine Receptor (14) Histone Acetyltransferase (4) Histone Demethylase (4) Histone Methyltransferase (4) HIV (13) HIV Protease (1) HMG-CoA Reductase (HMGCR) (1) HSP (8) HSV (5) Huntingtin (4) Hydroxycarboxylic Acid Receptor (HCAR) (1) IAP (1) ICMT (1) IFNAR (8) IGF-1R (1) iGluR (14) IKK (10) IKZF Family (1) Imidazoline Receptor (2) Indoleamine 2,3-Dioxygenase (IDO) (3) Influenza Virus (13) Insulin Receptor (5) Integrin (5) Interleukin Related (30) IRAK (5) IRE1 (1) Isotope-Labeled Compounds (29) Itk (3) JAK (8) JNK (5) Keap1-Nrf2 (19) Kinesin (1) Lactate Dehydrogenase (3) LAG-3 (3) LDLR (2) Leukotriene Receptor (1) LIM Kinase (LIMK) (1) Lipocalin Family (1) Liposome (10) Lipoxygenase (1) LPL Receptor (2) LRRK2 (3) LXR (1) mAChR (5) MAGL (4) MAP3K (2) MAP4K (2) Mas-related G-protein-coupled Receptor (MRGPR) (3) MCHR1 (GPR24) (2) MDM-2/p53 (14) MEK (3) Melanocortin Receptor (3) Melatonin Receptor (1) MetAP (1) mGluR (15) MHC (2) Microtubule/Tubulin (15) Mineralocorticoid Receptor (1) Mitochondrial Metabolism (7) Mitophagy (5) MMP (12) Monoamine Oxidase (20) Mps1 (1) mTOR (5) Na+/Ca2+ Exchanger (3) Na+/K+ ATPase (6) nAChR (7) NADPH Oxidase (2) NAMPT (3) Necroptosis (2) NEKs (4) Neprilysin (2) Neurokinin Receptor (1) Neuromedin U Receptor (NMUR) (2) Neuropeptide S Receptor (1) Neuropeptide Y Receptor (4) Neurotensin Receptor (1) NF-κB (37) NO Synthase (16) NOD-like Receptor (NLR) (10) Notch (5) Nuclear Factor of activated T Cells (NFAT) (2) Nuclear Hormone Receptor 4A/NR4A (3) Nucleoside Antimetabolite/Analog (4) OGA (1) Opioid Receptor (17) Orexin Receptor (OX Receptor) (5) Orphan Receptor (2) Orthopoxvirus (6) Oxidative Phosphorylation (1) P-glycoprotein (6) P-selectin (1) P2Y Receptor (2) p38 MAPK (13) p62 (2) PAK (2) Parasite (33) PARP (8) PCSK9 (1) PD-1/PD-L1 (4) PDHK (2) PERK (2) PGE synthase (5) Phosphatase (10) Phosphodiesterase (PDE) (10) Phospholipase (4) Phosphorylase (1) Photosystem II (3) PI3K (12) PI4P5K (1) Pim (7) PKA (6) PKC (11) PKD (3) Platelet-activating Factor Receptor (PAFR) (5) Polo-like Kinase (PLK) (1) Porcupine (1) Potassium Channel (8) PPAR (22) Progesterone Receptor (4) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (10) PROTAC Linkers (2) PROTACs (14) Protease Activated Receptor (PAR) (3) Proteasome (4) Protein Arginine Deiminase (2) Proton Pump (2) PSMA (6) PTEN (2) PTHR (2) Pyroptosis (1) Radionuclide-Drug Conjugates (RDCs) (6) Raf (3) RANKL/RANK (2) RAR/RXR (1) Ras (7) Reactive Oxygen Species (31) RET (2) Reverse Transcriptase (2) Ribosomal S6 Kinase (RSK) (3) RIP kinase (3) ROCK (5) ROR (3) ROS Kinase (8) RSV (1) RXFP Receptor (1) Salt-inducible Kinase (SIK) (2) SARS-CoV (23) Ser/Thr Kinase (1) Ser/Thr Protease (7) Serotonin Transporter (8) SF3B1 (1) SGK (3) SGLT (3) SHP2 (2) Sigma Receptor (8) Sirtuin (10) Small Interfering RNA (siRNA) (15) Sodium Channel (20) Somatostatin Receptor (2) SPFH Protein Superfamily (1) Src (4) SRPK (1) STAT (13) Stearoyl-CoA Desaturase (SCD) (5) STING (2) STK33 (1) Survivin (2) Syk (2) TAM Receptor (2) Tau Protein (7) Telomerase (3) TGF-beta/Smad (7) TGF-β Receptor (6) Thrombin (1) Thymidylate Synthase (1) Thyroid Hormone Receptor (2) Tie (2) TMV (1) TNF Receptor (15) Toll-like Receptor (TLR) (23) Topoisomerase (7) Transferrin Receptor (1) Transmembrane Glycoprotein (3) Trk Receptor (6) TRP Channel (13) TrxR (2) Tryptophan Hydroxylase (1) TSH Receptor (3) Tyrosinase (1) URAT1 (1) Urea Transporter (1) Vasopressin Receptor (1) VD/VDR (2) VEGFR (1) Virus Protease (8) WDR5 (2) Wnt (5) Xanthine Oxidase (3) YAP (1) YB-1 (1) Zinc Finger Protein (1) α-synuclein (3) β-catenin (2) β-glucuronidase (2) γ-secretase (7)
By Research Areas:	Cancer (500) Cardiovascular Disease (118) Endocrinology (28) Infection (213) Inflammation/Immunology (381) Metabolic Disease (249) Neurological Disease (393)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (1) Alkynes (5)
Oligonucleotides:	Solvents (1) Preservatives (1) Nucleosides and their Analogs (1) Nucleoside Phosphoramidites (1) Fillers (1) Phospholipids (1) Antisense Oligonucleotides (6) siRNAs (3) Aptamers (3) CpG ODNs (2) Cationic Lipids (5) Adjuvant (1) Human Pre-designed siRNA Sets (3)

1552

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

138

Peptides

MCE Kits

Inhibitory Antibodies

248

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13283

MF63 1 Publications Verification	PGE synthase	Inflammation/Immunology
MF63 is a selective and orally active inhibitor of mPGES-1. MF63 reduces the accumulation of PGE₂, relieves pyresis, hyperalgesia, and inflammatory pain by inhibiting mPGES-1 .

HY-N1503

Methyl deacetylasperulosidate 6α-Hydroxygeniposide; Deacetylasperulosidic acid methyl ester	Others	Metabolic Disease
Methyl deacetylasperulosidate is an iridoid and shows purgative effects in mice and lowers the blood glucose level in normal mice .

HY-124617

AMXT-1501 5+ Cited Publications	Apoptosis	Inflammation/Immunology Cancer
AMXT1501 is a novel inhibitor of the polyamine transport system. AMXT1501 blocks tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells .

HY-120872

AJS1669 free acid	Glycosyltransferase	Metabolic Disease
AJS1669 free acid is a potent and orally available glycogen synthase (GS) activator. AJS1669 improves glucose metabolism and reduces body fat mass in mice[1].

HY-RS08427

MICAL3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MICAL3 Human Pre-designed siRNA Set A contains three designed siRNAs for MICAL3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MICAL3 Human Pre-designed siRNA Set A MICAL3 Human Pre-designed siRNA Set A

HY-RS08425

MICAL1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MICAL1 Human Pre-designed siRNA Set A contains three designed siRNAs for MICAL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MICAL1 Human Pre-designed siRNA Set A MICAL1 Human Pre-designed siRNA Set A

HY-RS08426

MICAL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MICAL2 Human Pre-designed siRNA Set A contains three designed siRNAs for MICAL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MICAL2 Human Pre-designed siRNA Set A MICAL2 Human Pre-designed siRNA Set A

HY-139240

Cannabidihexol CBDH	Cannabinoid Receptor	Neurological Disease
Cannabidihexol is a phytocannabinoid with analgesic activity in mice .

HY-N1503R

Methyl deacetylasperulosidate (Standard)	Others	Metabolic Disease
Methyl deacetylasperulosidate (Standard) is the analytical standard of Methyl deacetylasperulosidate. This product is intended for research and analytical applications. Methyl deacetylasperulosidate is an iridoid and shows purgative effects in mice and lowers the blood glucose level in normal mice .

HY-130581

Lipid X	Bacterial Antibiotic	Infection
Lipid X is a novel monosaccharide precursor of Lipid A (the active moiety of gram-negative endotoxin). Lipid X is protective against endotoxin administered to mice and sheep and against life-threatening gram-negative infections in mice .

HY-116193

5-PAHSA	Endogenous Metabolite	Neurological Disease Metabolic Disease Inflammation/Immunology
5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics .

HY-119261

Ruboxyl	Antibiotic	Cancer
Ruboxyl is an anthracycline antibiotic with antitumor activity. Ruboxyl inhibits colorectal cancer (CRC) liver metastasis in mice by 84%, suppresses B16 melanoma growth, and increases the survival rate of mice with L1210 or L5178Y leukemia .

HY-131508

M&B 5124	Parasite	Infection
M&B 5124 is a potent inhibitor of Schistosoma mansoni in mice .

HY-101699A

AMG-076	MCHR1 (GPR24)	Metabolic Disease
AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice .

HY-B0448S

Phenytoin-d10 5,5-Diphenylhydantoin-d₁₀	Sodium Channel Virus Protease	Neurological Disease
Phenytoin-d₁₀ is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].

HY-106925

Cetefloxacin E 4868	Antibiotic Bacterial	Infection
Cetefloxacin (E 4868) is a board-spectrum antibacterial antibiotic, MIC of 0.007-8 µg/ml. Cetefloxacin exhibits good pharmacokinetic characters in mice. Cetefloxacin exhibits protective effects against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae in mice .

HY-N0260

Epmedin C 3 Publications Verification Epimedin-C; Baohuoside-VI	Others	Inflammation/Immunology
Epmedin C, a natural product, has estrogen-like effects for ovariectomized mice.

HY-124112

PAM 1392	Parasite	Infection
PAM 1392 is active orally against *Plasmodium berghei* in mice, *P. cynofologi* and *P. knowlesi* in monkeys and *Trypanosoma cruzi* in tissue cultures of mice, and *hemolytic streptococci* in vitro. PAM 1392 has antimalarial and antitrypanosomal activities, which is proming for rasearch of drug-resistant malaria .

HY-P1438A

Neuropeptide S(Rat) TFA	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide S(Rat) TFA is a potent endogenous neuropeptide S receptor (NSPR) agonist (EC₅₀=3.2 nM). Neuropeptide S(Rat) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Rat) TFA also reduces anxiety-like behavior in mice.

HY-109506S1

DPPC-d9 129Y83-d₉	Endogenous Metabolite	Others
DPPC-d₉ is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].

HY-109506S

DPPC-d62 129Y83-d₆₂	Isotope-Labeled Compounds Endogenous Metabolite	Others
DPPC-d₆₂ is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].

HY-N10279

Gymconopin C	Others	Infection
Gymconopin C shows an antiallergic effect on ear passive cutaneous anaphylaxis reactions in mice.

HY-N13293

Isopaynantheine 3-Isopaynantheine	Opioid Receptor	Neurological Disease
Isopaynantheine (3-Isopaynantheine), an alkaloid, is an opioid. Isopaynantheine has antinociceptive activity in mice.

HY-N6857C

(±)-Armepavine hydrochloride	PI3K Itk Phospholipase	Inflammation/Immunology
(±)-Armepavine hydrochloride is a compound that has demonstrated immunosuppressive effects on T lymphocytes and in lupus nephritic mice.

HY-126910

Mesyl Salvinorin B	Opioid Receptor	Metabolic Disease
Mesyl Salvinorin B is a potent and selective kappa opioid receptor (KOP-r) agonist. Mesyl Salvinorin B prevents the ADE (Alcohol deprivation effect) in mice. Mesyl Salvinorin B dose-dependently reduces alcohol intake and preference in CED (chronic escalation drinking) mice .

HY-109506S3

DPPC-d9-1 129Y83-d₉-1	Isotope-Labeled Compounds Endogenous Metabolite	Others
DPPC-d₉-1 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].

HY-101699

AMG-076 free base	MCHR1 (GPR24)	Metabolic Disease
AMG-076 free base is an orally bioavailable and selective MCHR1 antagonist. AMG-076 free base results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice .

HY-153392

TYA-018	Oxidative Phosphorylation HDAC	Cardiovascular Disease
TYA-018 is an orally active, potent and highly selective HDAC6 inhibitor. TYA-018 can protect heart function in mice. TYA-018 also enhances energetics in mice by increasing expression of targets associated with fatty acid metabolism, protein metabolism, and oxidative phosphorylation .

HY-P10110

retro-inverso TAT-Beclin 1 (D-amino acid)	Autophagy	Neurological Disease
retro-inverso TAT-Beclin 1 D-amino acid is has higher activity and resistance to proteolytic degradation in vivo compared to L-amino acids peptide. TAT-Beclin 1 can induce autophagy in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice .

HY-119218

LH 1	Others	Inflammation/Immunology
LH 1 is a potent immunostimulant used for the anti-PVP (polyvinylpyrrolidone) response in athymic mice .

HY-165014

2C-I-FLY hydrochloride	Drug Derivative	Neurological Disease
2C-I-FLY hydrochloride is a phenethylamine that induces the head-twitch response in mice .

HY-138289

4-acetoxy MPT	Drug Derivative	Neurological Disease
4-acetoxy MPT is a tryptamine that induces the head-twitch response (HTR) in mice .

HY-W040276

Diafen NN	Others	Cancer
Diafen NN is an antioxidant. Diafen NN induces leukoses and local sarcomas in mice . .

HY-118802

4-Hydroxy DPT	Drug Derivative	Neurological Disease
4-Hydroxy DPT is a tryptamine that induces the head-twitch response (HTR) in mice .

HY-124617A

AMXT-1501 tetrahydrochloride 5+ Cited Publications	Apoptosis	Inflammation/Immunology Cancer
AMXT-1501 tetrahydrochloride is an orally active polyamine transport inhibitor. AMXT1501 blocks tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells . Combination of DFMO and AMXT‐1501 induces caspase‐3 mediated apoptosis in NB cell lines .

HY-B1198

Piperonyl butoxide 1 Publications Verification ENT-14250	Parasite	Infection Cancer
Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice .

HY-B0448S1

Phenytoin-15n2,13c	Sodium Channel Virus Protease	Neurological Disease
Phenytoin- ¹⁵N₂, ¹³C is the ¹³C and ¹⁵N labeled Phenytoin[1]. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[2][3].

HY-W011890A

Cridanimod sodium	IFNAR	Infection
Cridanimod sodium is an antiviral agent that induces interferon production in mice. Cridanimod can be utilized in antiviral research .

HY-100751

N-563	Fungal	Others
N-563 is an analogue of deoxyspergualin with an immunostimulating activity,it promotes resistance to Candida albicans infection in mice.

HY-170717

3-Methylnordiazepam RO-5-2751	Drug Derivative	Neurological Disease
3-Methylnordiazepam (RO-5-2751) is a benzodiazepine and shows anticonvulsant activity in mice .

HY-153617

FOXO1-IN-3	FOXO	Metabolic Disease
FOXO1-IN-3 is a highly-selective and orally active FOXO1 inhibitor. FOXO1-IN-3 reduces hepatic glucose production in mice. FOXO1-IN-3 improves insulin sensitivity and glucose control in db/db mice without causing weight gain .

HY-110197

6bK TFA 1 Publications Verification	Insulin Receptor	Metabolic Disease
6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC₅₀ value of 50 nM. 6bK TFA increases circulating insulin in high-fat-fed mice. Acute administration of 6bK TFA enhances glucose tolerance to oral glucose, notably to a greater extent in high-fat-fed mice .

HY-100617A

(RS)-4CPG (RS)-4-Carboxyphenylglycine	mGluR	Others
(RS)-4CPG ((RS)-4-Carboxyphenylglycine) is a type I metabotropic glutamate receptor antagonist with activity in blocking LTP induction. In mice lacking IP3R1, (RS)-4CPG (500μM) nearly blocked long-term potentiation (LTP) induced by type I metabotropic glutamate receptor activation, with LTP of 117.6±1.7% (n = 8) in IP3R1(-/-) mice and 116.9±1.8% (n = 5) in IP3R1(+/+) mice.

HY-N3098

Pelirine	Others	Others
Pelirine is an alkaloid isolated from R. perakensis and causes death in mice at concentrations of 100 mg/kg and above .

HY-156193

PF-07208254	Endogenous Metabolite	Cardiovascular Disease
PF-07208254 is a potent inhibitor of BDK. PF-07208254 improves cardiometabolic endpoints in mice .

HY-N9794

Isoboldine	Others	Inflammation/Immunology
Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice .

HY-U00008

CP-28888 CP 28888-27	IFNAR	Infection
CP-28888 is an interferon inducer, more potent in mice, but is less active in man and devoid of antirhinovirus effects.

HY-118113

BVT-116429	11β-HSD	Others
BVT-116429 is an 11βHSD1 inhibitor with the activity of increasing adiponectin concentration and improving glucose homeostasis in diabetic mice. BVT-116429 can increase plasma adiponectin levels in diabetic KKAy mice, reduce basal insulin levels, and reduce fasting blood glucose levels after 10 days of inhibition, similar to the effect of rosiglitazone.

HY-P5724

Nv-CATH	Bacterial	Infection
Nv-CATH is an antibacterial peptide of frog origin. Nv-CATH has broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria. Nv-CATH significantly protects mice from fatal infections caused by Staphylococcus aureus. Nv-CATH protects mice from bacterial infection through antimicrobial immunoregulatory duality .

HY-12242

GBR 12935 dihydrochloride	Dopamine Transporter	Neurological Disease
GBR 12935 dihydrochloride is a potent, and selective dopamine reuptake inhibitor, with the binding constant (K_d) of 1.08 nM in COS-7 cells. GBR 12935 dihydrochloride stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 dihydrochloride also prevents the d-Fenfluramine-induced head-twitch response in mice .

Cat. No.	Product Name	Type

HY-D0211

Phenolphthalein	Fluorescent Dyes/Probes
Phenolphthalein is an acid-base indicator that is colorless in an acidic environment and pink in an alkaline environment. Phenolphthalein is genotoxic and potentially carcinogenic to mice. In addition, phenolphthalein is also a blood indicator .

HY-150236

FITC-labeled Tominersen sodium	Dyes
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

HY-15096

MKT-077 5+ Cited Publications FJ-776	Dyes
MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity . MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm .

HY-D2203

BODIPY BDP4	Fluorescent Dyes/Probes
BODIPY BDP4 has ssuperb sonosensitivity and high SDT efficiency against cancer cells and tumors in tumor-bearing mice .

HY-D1535

IR 813 perchlorate	Fluorescent Dyes/Probes
IR 813 perchlorate is a near-infrared (NIR) fluorescent dye (Ex=815 nm, Em=840 nm) and can be used for visualizing regional lymph nodes in mice .

HY-D2095

Medical fluorophore 33	Fluorescent Dyes/Probes
Medical fluorophore 33 is a novel quinoline-isoquinoline salt. Medical fluorophore 33 exhibits a strong fluorescent signal, good microsomal stability and high biocompatibility in vivo. Medical fluorophore 33 has antitumor activity in colorectal cancer mice .

HY-D1066

NIR-Thiol dinitrobenzenesulfonate	Fluorescent Dyes/Probes
NIR-Thiol dinitrobenzenesulfonate has both absorption and emission in the NIR region. NIR-Thiol dinitrobenzenesulfonate responds to thiol with a large turn-on NIR fluorescence signal upon excitation in the NIR region. NIR-Thiol dinitrobenzenesulfonate is capable of imaging endogenously produced thiol in living cells and mice .

HY-D2279

NFL-NH2	Fluorescent Dyes/Probes
NFL-NH2 is a mitochondrial-targeted near-infrared ratiometric fluorescent probe. NFL-NH2 can rapidly detect NO levels associated with the inflammatory damage degree in rheumatoid arthritis (RA) mice models by ratiometric fluorescence imaging. The excitation wavelength and emission wavelength are 650 nm and 780 nm, respectively .

HY-D1460

Fluorescein Di-β-D-Glucuronide

Fluorescent Dyes/Probes

Fluorescein Di-β-D-Glucuronide, a fluorescent probe, can be utilized to non-invasively image the intestinal bacterial β-glucuronidase activity in nude mice. Fluorescein Di-β-D-Glucuronide-based imaging reveals the in vitro and in vivo activity of intestinal bacterial β-glucuronidase, which would facilitate pharmacodynamic studies of specific bacterial β-glucuronidase inhibitors in animal studies .

HY-149696

IR-Crizotinib

Dyes

IR-Crizotinib is a NF-κB-inducing kinase (NIK) inhibitor that crosses the blood-brain barrier and fluorescently localizes intracranial glioblastoma (GBM) in mice (IC₅₀=3.381 μM). IR-Crizotinib is conjugated from the near-infrared dye IR-786 and the NF-κB-inducing kinase (NIK) inhibitor Crizotinib. IR-Crizotinib can effectively inhibit the growth and invasion of glioma in vitro and in vivo and can be used in cancer research .

HY-107614G

1-Oleoyl lysophosphatidic acid (sodium) (GMP)

1-Oleoyl-sn-glycero-3-phosphate (sodium) (GMP); 1-Oleoyl-LPA (sodium) (GMP)

Fluorescent Dye

1-Oleoyl lysophosphatidic acid sodium (GMP) is a GMP-grade 1-Oleoyl lysophosphatidic acid sodium that can be used as an auxiliary reagent in cell therapy. 1-Oleoyl lysophosphatidic acid sodium can stimulate neuronal differentiation in neural progenitor cells from mice or rats, and it also promotes the differentiation of human adipose-derived mesenchymal stem cells into myofibroblast-like cells in vitro by activating the autocrine TGF-β1-Smad signaling pathway .

HY-D1065

NIR-H2O2	Fluorescent Dyes/Probes
NIR-H2O2 is a cell-permeable near-infrared (NIR) fluorescent turn-on sensor. NIR-H2O2 has both absorption and emission in the NIR region. NIR-H2O2 responds to H₂O₂ with a large turn-on NIR fluorescence signal upon excitation in the NIR region. NIR-H2O2 is capable of imaging endogenously produced H₂O₂ in living cells and mice .

HY-16561G

Resveratrol (GMP)

trans-Resveratrol (GMP); SRT501 (GMP)

Fluorescent Dye

Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

Cat. No.	Product Name	Type

HY-W100403

Choline tosylate 2 Publications Verification Choline p-toluenesulfonate	Enzyme Substrates
Choline tosylate is a nucleophilic compound that inhibits phospholipase A2 and phospholipase C. Choline tosylate inhibits tumor growth in mice by inhibiting the formation of diacylglycerol (DAG) .

HY-NP003

Collagen, Type II, from bovine snout membrane 1 Publications Verification Collagen	Native Proteins
Collagen, Type II, from bovine snout membrane is a type II collagen that can induce osteoarthritis by eliciting a strong and sustained T cell response. Type II collagen can be used to model collagen-induced arthritis in mice .

HY-40156

5-Fluoroindole	Biochemical Assay Reagents
5-Fluoroindole is an antibacterial agent, that inhibits Mycobacterium tuberculosis with a MIC of 4.7 μM. 5-Fluoroindole exhibits metabolic stability in rat liver microsomes. 5-Fluoroindole exhibits anti-tuberculosis efficacy in mice .

HY-D0873

HEPPS EPPS	Buffer Reagents
HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier .

HY-B2241A

Potassiumalum, for cell culture Aluminum potassium sulfate dodecahydrate, for cell culture	Cell Assay Reagents
Potassiumalum, for cell culture (Aluminum potassium sulfate dodecahydrate, for cell culture) is an egg white adjuvant that can induce allergic reactions in mice; it can also be used for bacterial staining. Potassiumalum, for cell culture is a biomaterial or organic compound that can be used in life science research .

HY-109506

DPPC 5+ Cited Publications 129Y83	Drug Delivery
DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .

HY-N1428A

Citric acid monohydrate Maximum Cited Publications 28 Publications Verification	Buffer Reagents
Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice .

HY-W250113

Zymosan A 1 Publications Verification Zymosan A from Saccharomyces cerevisiae	Carbohydrates
Zymosan A (Zymosan A from Saccharomyces cerevisiae) is a TLR2 agonist, that targeting TLRs can prevent and suppress IR-induced intestinal injury. Zymosan A exhibits a significant radioprotective effect, and protects IR-induced intestinal injury in mice. Zymosan A promotes the regeneration of intestinal stem cells (ISCs), after IR injury .

HY-158272

Penicillin/OVA	Biochemical Assay Reagents
Penicillin/OVA is a conjugate of penicillin and Ovalbumins (HY-W250978), that is utilized as an antigen in immunological research. Penicillin/OVA causes IgE-dependent anaphylactic response to penicillin in mice .

HY-W331017

1-Hexacosanoyl-sn-glycero-3-phosphocholine 26:0 Lyso PC	Drug Delivery
1-Hexacosanoyl-sn-glycero-3-phosphocholine (26:0 Lyso PC) is a long-chain fatty acid. 1-Hexacosanoyl-sn-glycero-3-phosphocholine can be used as a biomarker for X-linked adrenoleukodystrophy (ALD) in mice .

HY-B2201

Citric acid trisodium Maximum Cited Publications 28 Publications Verification Sodium citrate; Trisodium citrate anhydrous	Buffer Reagents
Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice .

HY-109506R

DPPC (Standard)

Drug Delivery

DPPC (Standard) is the analytical standard of DPPC. This product is intended for research and analytical applications. DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .

HY-Y1275

N-Methylpyrrolidone NMP; 1-Methyl-2-pyrrolidinone	Co-solvents
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD₅₀ value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-N1428AR

Citric acid monohydrate (Standard)

Buffer Reagents

Citric acid (monohydrate) (Standard) is the analytical standard of Citric acid (monohydrate). This product is intended for research and analytical applications. Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice .

HY-157252

CL4F8-6	Drug Delivery
CL4F8-6 is an ionizable cationic lipid with a pK_a of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics. CL4F8-6 LNPs carrying Cas9 mRNA and sgRNA could induce CRISPR-mediated gene knockdown in mice .

HY-107614G

1-Oleoyl lysophosphatidic acid (sodium) (GMP)

1-Oleoyl-sn-glycero-3-phosphate (sodium) (GMP); 1-Oleoyl-LPA (sodium) (GMP)

Biochemical Assay Reagents

HY-44134

Dimethyl 2-oxoglutarate

Dimethyl α-ketoglutarate

Biochemical Assay Reagents

Dimethyl 2-oxoglutarate (Dimethyl α-ketoglutarate), a cell permeable 2-oxoglutarate derivative, is a tricarboxylic acid cycle metabolite with antioxidant properties. Dimethyl 2-oxoglutarate serves as a crucial intermediate in the Krebs cycle and an essential nitrogen carrier in metabolic pathways during biological processes. Dimethyl 2-oxoglutarate inhibits autophagy in an IDH1-, IDH2- and ACLY-dependent fashion in cultured human cells. Dimethyl 2-oxoglutarate efficiently prevents autophagy induced by starvation in mice .

HY-16561G

Resveratrol (GMP)

trans-Resveratrol (GMP); SRT501 (GMP)

Biochemical Assay Reagents

HY-W001925

7-Methoxy-1-tetralone

Biochemical Assay Reagents

7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index .

HY-124187

Pinolenic acid ethyl ester

Ethyl pinolenate

Drug Delivery

Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

HY-D1056A5

Lipopolysaccharides, from E. coli K-235

LPS, from Escherichia coli (K-235)

Carbohydrates

Lipopolysaccharides, from E. coli (Escherichia coli) K-235 are lipopolysaccharide endotoxins and TLR-4 activators derived from E. coli, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from E. coli K-235 exhibit a typical three-part structure: O-antigen (O-antigen), core oligosaccharide (core oligosaccharide), and lipid A (Lipid A). Lipopolysaccharides, from E. coli K-235 have a mitogenic effect on C57BL/10ScN spleen cells. Additionally, LPS purified using butanol and deoxycholic acid methods stimulates spleen cells in C57BL/10ScCR and C3H/HeJ mice .

Cat. No.	Product Name	Target	Research Area

HY-P99797

Pabinafusp alfa JR-141	Transferrin Receptor	Neurological Disease
Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice .

HY-P9960

Ocrelizumab	CD20	Inflammation/Immunology
Ocrelizumab (Ocrevus) is a humanized anti-CD20 monoclonal antibody. Ocrelizumab can induce B cell depletion and inhibit multiple sclerosis lesions in mice through antibody dependent cytotoxicity (ADCC) .

HY-P99199

Foralumab NI-0401	CD3	Inflammation/Immunology
Foralumab (NI-0401) is a potent, orally active human monoclonal antibody targeting the CD3. Foralumab modulates immune responses by human cells in NSG mice that were reconstituted with human hematopoietic stem cells .

HY-P9944

Palivizumab 1 Publications Verification MEDI 493	RSV	Infection Inflammation/Immunology Cancer
Palivizumab (MEDI 493) is a humanized monoclonal antibody against respiratory syncytial virus (RSV). Palivizumab can bind to RSV F protein with a K_d value of 1.4 nM. Palivizumab can prevent respiratory syncytial virus infection in cotton mice .

HY-P99216

Ponezumab 1 Publications Verification PF-04360365; RN 1219	EGFR	Neurological Disease
Ponezumab (PF-04360365) is a humanised anti-amyloid IgG2 monoclonal antibody. Ponezumab reduces Aβ levels in the central nervous system and improves performance in mice in various models of learning and memory. Ponezumab can be used in study of Alzheimer's disease .

HY-P99908

Efineptakin alfa NT-17	Interleukin Related	Cancer
Efineptakin alfa (NT-17) is a long-acting recombinant human IL-7. Efineptakin alfa supports the proliferation and survival CD4 ⁺ and CD8 ⁺ cells in both human and mice. Efineptakin alfa can be used for glioblastoma research .

HY-P99922

Encelimab	LAG-3	Cancer
Encelimab is an anti-LAG3 antibody. Encelimab blocks the interaction between LAG-3 and MHC II, and enhances T-cell activation. Encelimab alone or in combination with an anti-PD-1 antibody reduces tumor size in a lymphoma mice model (A20 cell xenograft) .

HY-P99708

Livmoniplimab ABBV-151; ARGX-115	TGF-beta/Smad	Cancer
Livmoniplimab (ABBV-151) is a monoclonal antibody against GARP/TGF-β1 that can inhibit the release of active TGF-β1. Livmoniplimab has anti-tumor activity in colon cancer mice. Livmoniplimab can be used for the study of locally advanced or metastatic solid tumors .

HY-P99554

Topsalysin PRX-302	PSMA	Cancer
Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle .

HY-P99354

Bavunalimab Anti-Human CTLA4xLAG3	LAG-3	Inflammation/Immunology Cancer
Bavunalimab (Anti-Human CTLA4xLAG3) is a bispecific human anti-CTLA-4/LAG-3 monoclonal antibody. Bavunalimab activates T cells in NSG mice. Bavunalimab can be used for the research of cancer .

HY-P99194

Evinacumab REGN1500	ANGPTL	Cardiovascular Disease Metabolic Disease
Evinacumab (REGN1500) is a human anti-ANGPTL3 (angiopoietin-like protein 3) monoclonal antibody (IgG4 class antibody). Evinacumab reduces plasma lipids in dyslipidemic mice by blocking ANGPTL3. Evinacumab can be used in studies of homozygous familial hypercholesterolaemia (HoFH), refractory hypercholesterolaemia (both familial and non-familial) and severe hypertriglyceridaemia .

HY-108786

Asfotase alfa ENB-0040	Phosphatase	Metabolic Disease
Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2 ^?/? knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP) .

HY-P99588

Stamulumab MYO-029	TGF-β Receptor	Metabolic Disease
Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research .

HY-P99583

Suvratoxumab MEDI4893	Bacterial	Infection Inflammation/Immunology
Suvratoxumab (MEDI4893) is a long-acting, high-affinity human anti-α-toxin monoclonal antibody (IgG1κ type). Suvratoxumab potently neutralizes α-toxin, a key S. aureus virulence factor. Suvratoxumab improves survival and reduces lung injury in an immunocompromised mice model of pneumonia. Suvratoxumab also enhances the antibacterial activity of Vancomycin (HY-B0671) or Linezolid (HY-10394) .

HY-P99156

Relatlimab BMS-986016	LAG-3	Cancer
Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC₅₀ value of 0.67 nM and LAG-3/FGL1 interaction with an IC₅₀ value of 0.019 nM. Relatlimab can be used in research of cancer .

HY-P9983

Lintuzumab HuM-195	Transmembrane Glycoprotein Radionuclide-Drug Conjugates (RDCs)	Inflammation/Immunology
Lintuzumab (HUM-195) is an anti-CD33 humanized monoclonal antibody. Lintuzumab reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells. Lintuzumab promotes tumor cell killing through antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) activities against MDR? and MDR+ AML cell lines and primary AML patient samples. Lintuzumab enhances survival and reduces tumor burden in mice .

HY-P99341

Casirivimab REGN10933	SARS-CoV	Infection
Casirivimab (REGN10933) is a human monoclonal antibody that targets the SARS-CoV-2 virus, which causes COVID-19. Casirivimab is ineffective against COVID-19 variants. Casirivimab can be used in combination with Imdevimab (HY-P99342), which alters the lung response of K18-hACE2 mice to the SARS-CoV-2 δ variant, effectively reducing viral load and improving symptoms .

HY-P99163

Tilavonemab ABBV-8E12; C2N-8E12	Tau Protein	Neurological Disease
Tilavonemab (ABBV-8E12) is a humanized anti-tau antibody that targets the extracellular form of pathological tau protein aggregates by binding to the N-terminal 25-30 amino acid residues of tau protein. Tilavonemab blocks the ability of human and mouse neurons to take up tau aggregates, reduces the loss of brain volume, slows the progression of tau pathology, and improves cognitive abilities in transgenic mice expressing mutant human tau. Tilavonemab is used in Alzheimer's disease research .

HY-P99620

Firivumab CT-P22; CT120	Influenza Virus	Infection
Firivumab (CT-P22; CT120) is a human IgG1 monoclonal influenza A virus hemagglutinin (Anti-IAV HA) antibody. Firivumab is capable of neutralizing H1N1, H5N1, H6N1, H6N2, H8N4, H8N8, H9N2 and H12N7. Firivumab shows protection against H1N1 virus in mice .

HY-P99744

Modakafusp alfa TAK-573	CD38	Inflammation/Immunology Cancer
Modakafusp alfa (TAK-573) is a humanized, anti-CD38 IgG4 monoclonal antibody fused to 2 attenuated IFNα2b molecules, which delivers interferon-alpha to CD38-expressing cells. Modakafusp alfa has direct anti-proliferative activity on multiple myeloma (MM) cancer cells in vitro and induces robust and durable antitumor responses in MM xenograft tumor models. Modakafusp alfa in combination with anti-PD-1 antibodies induces immunomodulation and antitumor responses with good tolerance in mice .

HY-P99048

Sintilimab IBI308	PD-1/PD-L1	Inflammation/Immunology Cancer
Sintilimab (IBI308) is a safe and effectivel humanized IgG4 monoclonal antibody that binds to PD-1 with a K_D value of 74 pM. Sintilimab blocks the interaction of PD-1 with its ligands (PD-L1 and PL-L2), consequently helping to restore the endogenous antitumour T-cell response. Sintilimab combined with prebiotics inhibits tumor volume and regulates immune cell subpopulation balance in lung adenocarcinoma mice. Sintilimab can be used for the research of classical Hodgkin's lymphoma, non-small cell lung cancer and oesophageal cancer .

HY-P99048A

Sintilimab (Anti-PD-1) IBI308 (Anti-PD-1)	PD-1/PD-L1	Inflammation/Immunology Cancer
Sintilimab (Anti-PD-1) (IBI308 (Anti-PD-1)) is a safe and effectivel humanized IgG4 monoclonal antibody that binds to PD-1 with a K_D value of 74 pM. Sintilimab (Anti-PD-1) blocks the interaction of PD-1 with its ligands (PD-L1 and PL-L2), consequently helping to restore the endogenous antitumour T-cell response. Sintilimab (Anti-PD-1) combined with prebiotics inhibits tumor volume and regulates immune cell subpopulation balance in lung adenocarcinoma mice. Sintilimab (Anti-PD-1) can be used for the research of classical Hodgkin's lymphoma, non-small cell lung cancer and oesophageal cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1503

Methyl deacetylasperulosidate 6α-Hydroxygeniposide; Deacetylasperulosidic acid methyl ester	Structural Classification Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Metabolic Disease Plants Disease Research Fields Hedyotis diffusa Willd.	Others
Methyl deacetylasperulosidate is an iridoid and shows purgative effects in mice and lowers the blood glucose level in normal mice .

HY-N0260

Epmedin C 3 Publications Verification Epimedin-C; Baohuoside-VI	Flavonols Flavonoids Monophenols Classification of Application Fields Source classification Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields Inflammation/Immunology	Others
Epmedin C, a natural product, has estrogen-like effects for ovariectomized mice.

HY-156193

PF-07208254	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
PF-07208254 is a potent inhibitor of BDK. PF-07208254 improves cardiometabolic endpoints in mice .

HY-N0204

Pulchinenoside A Anemoside A3	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Ranunculaceae Other Diseases Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel	iGluR
Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice.

HY-N0700

alpha-Asarone α-Asarone; trans-Asarone	Acorus tatarinowii Schott Structural Classification Simple Phenylpropanols Araceae Source classification Phenylpropanoids Plants	GABA Receptor
alpha-Asarone (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice.

HY-N1503R

Methyl deacetylasperulosidate (Standard)	Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants Hedyotis diffusa Willd.	Others
Methyl deacetylasperulosidate (Standard) is the analytical standard of Methyl deacetylasperulosidate. This product is intended for research and analytical applications. Methyl deacetylasperulosidate is an iridoid and shows purgative effects in mice and lowers the blood glucose level in normal mice .

HY-N10279

Gymconopin C	Infection other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	Others
Gymconopin C shows an antiallergic effect on ear passive cutaneous anaphylaxis reactions in mice.

HY-N13293

Isopaynantheine 3-Isopaynantheine	Structural Classification Alkaloids Other Alkaloids Source classification Rubiaceae Mitragyna speciosa Korth. Plants	Opioid Receptor
Isopaynantheine (3-Isopaynantheine), an alkaloid, is an opioid. Isopaynantheine has antinociceptive activity in mice.

HY-N3098

Pelirine	Apocynaceae Rauvolfia verticillata (Lour.) Baill. Structural Classification Alkaloids Source classification Plants Indole Alkaloids	Others
Pelirine is an alkaloid isolated from R. perakensis and causes death in mice at concentrations of 100 mg/kg and above .

HY-N9794

Isoboldine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Phenols Polyphenols Plants Lauraceae Lindera aggregata (Sims) Kosterm.	Others
Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice .

HY-N10196

Cerebroside D	Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Inflammation/Immunology	Endogenous Metabolite
Cerebroside D, a glycoceramide compound, improves experimental colitis in mice with multiple targets against activated T lymphocytes .

HY-N10424

Brazilein	Structural Classification Classification of Application Fields Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Pigments Plants Inflammation/Immunology Disease Research Fields Food Research	Apoptosis
Brazilein is an important immunosuppressive component isolated from Caesalpinia sappan L. Brazilein induces apoptosis in mice spleen lymphocytes .

HY-122916

7-Acetyllycopsamine	Alkaloids other families Pyrrole Alkaloids Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology	Others
7-Acetyllycopsamine, a pyrrolizidine alkaloid, is a mild hepatotoxin. 7-Acetyllycopsamine can induce liver inflammation in mice .

HY-N15180

Corynantheidine (-)-Corynantheidine	Structural Classification Alkaloids Source classification Rubiaceae Mitragyna speciosa Korth. Plants Indole Alkaloids	Opioid Receptor
Corynantheidine ((-)-Corynantheidine) is a mu-opioid receptor (MOR) partial agonist that shows MOR-dependent analgesic effects in mice .

HY-W009688

Dibutyl maleate	Natural Products Rheum palmatum L. Classification of Application Fields Polygonaceae Source classification Plants Inflammation/Immunology Disease Research Fields	Drug Intermediate
Dibutyl maleate, the diester of the Maleic Acid, can be used as an intermediate of pharmaceutical synthesis. Dibutyl maleate can enhance contact sensitization to Fluorescein isothiocyanate in mice .

HY-N10346A

Gluconapin	Structural Classification Brassica rapa L. Ketones, Aldehydes, Acids Source classification Plants Brassicaceae	Endogenous Metabolite
Gluconapin is a precursor of sulforaphane, a potent anticancer isothiocyanate. Gluconapin reduces the increase in plasma triglycerides induced by corn oil in mice .

HY-N1149

Tilifodiolide (-)-Tilifodiolide	Structural Classification Terpenoids Labiatae Artemisia cana Pursh Source classification Diterpenoids Plants	Others
Tilifodiolide ((-)-Tilifodiolide) is a lactone, which can be isolated from the roots of Salvia tiliaefolia. Tilifodiolide has anti-inflammatory activity in mice model .

HY-N5126

Juncusol	Natural Products other families Source classification Phenols Polyphenols Plants	Others
Juncusol, a phenanthrenoid found in Juncus setchuenensis, possesses anxiolytic effect. Juncusol is associated with metabolic changes in cortical serotonin/dopamine levels in Mice .

HY-N10359

Isoandrographolide	Andrographis paniculata (Burm. F.) Nees Classification of Application Fields Acanthaceae Terpenoids Source classification Diterpenoids Plants Disease Research Fields Inflammation/Immunology	NOD-like Receptor (NLR)
Isoandrographolide possesses cell differentiation inducing and hepatoprotective effect. Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice .

HY-124557

Mahanimbine	Structural Classification Alkaloids Classification of Application Fields Source classification Rutaceae Murraya koenigii (L.) Spreng Carbazole Alkaloids Plants Murraya exotica L. Mant. Inflammation/Immunology Disease Research Fields Indole Alkaloids	NF-κB
Mahanimbine is an orally active alkaloid from Murraya koenigii. Mahanimbine inhibits progression of high-fat diet (HFD)-induced metabolic complications in mice .

HY-114651

Phenazoviridin	Structural Classification Microorganisms Source classification Saccharides Monosaccharides	Others
Phenazoviridin is a free radical scavenger. Phenazoviridin shows strong inhibitory activity against lipid peroxidation in rat brain homogenate and exhibits antihypoxic activity in mice .

HY-N8522

9,10-Dihydroxystearic acid	Classification of Application Fields Ricinus communis L. Ketones, Aldehydes, Acids Source classification Metabolic Disease Euphorbiaceae Plants Disease Research Fields	Others
9,10-Dihydroxystearic acid is an oxidation product of oleic acid. 9,10-Dihydroxystearic acid can improve glucose tolerance and insulin sensitivity in KKAy mice .

HY-N11021

Feruloyl tyramine	Structural Classification Alkaloids Cannabis sativa L Source classification Phenols Plants Moraceae	Others
Feruloyl tyramine, an amide compound, can be isolated from ethanol extract of hemp seed. Feruloyl tyramine injected into the lateral ventricle caused hypothermia and dyskinesia in mice .

HY-N3506

Wilfortrine	Infection Alkaloids Classification of Application Fields Source classification Celastraceae Pyridine Alkaloids Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology	HIV
Wilfortrine is a bioactive sesquiterpene alkaloid. Wilfortrine exhibits immunosuppresive effects. Wilfortrine also can inhibit leukaemia cell growth in mice and shows anti-HIV activity .

HY-113412A

3-Methylhistamine dihydrochloride	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
3-Methylhistamine dihydrochloride is a degradation product of histamine. 3-Methylhistamine dihydrochloride, a methylated product of histamine, is associated with immune response and shows upregulation in the vaccinated mice .

HY-N0546

Ligustroflavone Nuezhenoside	Structural Classification Flavonoids Oleaceae Classification of Application Fields Flavones Ligustrum lucidum Ait. Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	CaSR
Ligustroflavone, extracted from Ligustrum lucidum, is a potential candidate as calcium-sensing receptor (CaSR) antagonist. Ligustroflavone exhibits protective effects against diabetic osteoporosis in mice .

HY-129577

Aplysin	Structural Classification Natural Products Animals Source classification	Necroptosis
Aplysin is a brominated sesquiterpene with an isoprene backbone that exhibits hepatoprotective, immunomodulatory, and antitumor activities. Aplysin effectively prevents spontaneous pancreatic necrosis and inflammatory responses in NOD mice .

HY-155236

Ancistrotecine B	Structural Classification Alkaloids Piperidine Alkaloids Source classification Ancistrocladus tectorius (Lour.) Merr. Plants Ancistrocladaceae	Sodium Channel
Ancistrotecine B (Compound 2) is a Nav1.7 channel inhibitor (IC₅₀: 0.73 μM). Ancistrotecine B relieves inflammatory pain in mice .

HY-N3204

Neoechinulin A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite Indole Alkaloids	Apoptosis
Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice .

HY-N3960

Glycyrin	Structural Classification Leguminosae Source classification Coumarins Phenylpropanoids Plants Glycyrrhiza uralensis Fisch.	PPAR Bacterial
Glycyrin is a PPAR-γ ligand of licorice. Glycyrin can decrease the blood glucose levels of genetically diabetic mice. Glycyrin also shows antibacterial activity .

HY-106947

SY-640	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
SY-640 is an Acetamide derivative and has potent hepatoprotective effect. SY-640 reduces Propionibacterium acnes and Lipopolysaccharide-induced liver injury in mice .

HY-N15182

4-Trehalosamine	Structural Classification Microorganisms Antibiotics Source classification	Bacterial Drug Derivative
4-Trehalosamine is a derivative of trehalose with weak antibacterial activity. 4-Trehalosamine shows no toxic effects when injected intravenously into mice at a dose of 625 mg/kg .

HY-N13715

Thalicminine	Structural Classification Alkaloids Other Alkaloids Ranunculaceae Source classification Plants Thalictrum isopyroides C. A. Mey. in Ledebour	Endogenous Metabolite
Thalicminine is an alkaloid, which is found in Thalictrum species. Thalicminine can cause respiratory stimulation and a brief hypotensive effect on dogs. Thalicminine also prolongs the hypnotic effect of Chloral hydrate in mice .

HY-N12719

Isocampneoside I	Structural Classification Source classification Phenols Polyphenols Orobanchaceae Cistanche tubulosa (Schenk) Wight Plants	Others
Isocampneoside I is an acylated phenethyl oligosaccharide that can be isolated from Cistanche deserticola (Orobanchaceae). Isocampneoside I inhibits D-galactose-induced cytotoxicity and protects primary hepatocytes in mice .

HY-138100

Hyalodendrin (+)-Hyalodendrin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Fungal
Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .

HY-N10171

GB-2a	Structural Classification Flavonoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis Other Flavonoids	Others
GB-2a is a bioflavonoids that can be isolated from Rheedia gardneriana. GB-2a has significant analgesic activity in mice with 58.9% inhibition .

HY-N9685

Digitoxose D-(+)-Digitoxose	Plantaginaceae Digitalis purpurea L. Structural Classification Natural Products Source classification Plants	Biochemical Assay Reagents
Digitoxose (D-(+)-Digitoxose), a natural product, specifically and competitively inhibits glucose-stimulated insulin release from islets in lean and obese mice. Digitoxose can be used in diabetes research .

HY-N0541

Pseudoginsenoside F11 1 Publications Verification Ginsenoside A1	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Plants Endogenous metabolite Disease Research Fields Araliaceae	Endogenous Metabolite
Pseudoginsenoside F11 (Ginsenoside A1), a component of Panax quinquefolium (American ginseng), has been demonstrated to antagonize the learning and memory deficits induced by scopolamine, morphine and methamphetamine in mice.

HY-N6774

Cytochalasin C 1 Publications Verification	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields	Others
Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D .

HY-N8317

Rubicordifolin	Structural Classification Natural Products Source classification Rubiaceae Plants Rubia cordifolia L.	Others
Rubicordifolin is a natural product that can be isolated from Rubia cordifolia. Rubicordifolin inhibits the growth of sarcoma ascites in mice. Rubicordifolin has significant cytotoxic activity both in vitro and in vivo .

HY-129469

Saframycin S	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic
Saframycin S is an antibiotic with a racemomycin group that exhibits inhibitory activity against Ehrlich ascites tumors. The LD₅₀ of Saframycin S in ddY mice is 3.2 mg/kg (i.p.) .

HY-N13894

Auramycin A	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Antibiotic Bacterial
Auramycin A, an anthracycline antibiotic that shows marked antibacterial activity against Gram-positive bacteria. Auramycin A also exhibits antitumor activity against P388 and L1210 leukemia in mice .

HY-N4243

Neocurdione	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Metabolic Disease Plants Curcuma phaeocaulis Valeton Disease Research Fields Zingiberaceae	Others
Neocurdione is a hepatoprotective sesquiterpene isolated from Curcuma zedoaria rhizome. Neocurdione exerts potent effect on D-galactosamine- (D-Gain) and lipopolysaccharide- (LPS) induced acute liver injury in mice .

HY-118992

Aurodox X 5108; Goldinomycin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Fields Other Antibiotics	Antibiotic Bacterial
Aurodox (X 5108) is an antibiotic obtained from a streptomyces variant, Aurodox can against a number of gram-positive bacteria. Aurodox shows a very low toxicity in mice and promoted poultry growth .

HY-121229A

(±)-Coniine 2-Propylpiperidine	Alkaloids Piperidine Alkaloids Structural Classification Tsuga chinensis (Franch.) Pritz. Classification of Application Fields Pinaceae Source classification Other Diseases Plants Disease Research Fields	nAChR
(±)-Coniine (2-Propylpiperidine) is a piperidine alkaloid and nAChR agonist (EC₅₀=0.3 mM). (±)-Coniine is acutely toxic to mice with an LD50 value of 7.7 mg/kg .

HY-N1546

Protoplumericin A	Apocynaceae Structural Classification Polysaccharides Allamanda schottii Source classification Plants Saccharides	Others
Protoplumericin A is a bioactive ingredient of Plumeria obtusa L. attenuates. Protoplumericin A mitigated lipopolysaccharide (LPS) -induced acute lung injury in mice. Protoplumericin A can be used to study the LPS-induced anti-inflammatory effect .

HY-156126

Lentztrehalose C	Structural Classification Natural Products Microorganisms Source classification	Others
Lentztrehalose C (compound LTC) is a trehalose analogue with high stability in microbial and mammalian cells. It can be detected in the blood of mice and is ultimately excreted in feces and urine. It can induce autophagy in human cancer cells.

HY-114969

Clioxanide NSC 233846; SYD 230; Tremerad	Structural Classification Natural Products Animals Source classification	Parasite
Clioxanide is a potential anti-liver fluke (Fasciola hepatica) agent. The results showed that Clioxanide showed no efficacy against 4-week-old or 19-week-old flukes at doses of 135 mg/kg or 200 mg/kg. In contrast, hexachloroethane was very effective against older flukes, reaching 100% efficacy at lower doses. The study pointed out that laboratory mice may not be suitable for screening potential compounds against liver fluke infections in ruminants such as cattle and sheep. In addition, no obvious toxic reactions were observed in mice with Clioxanide .

HY-N13895

Auramycin B	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Antibiotic Bacterial
Auramycin B, an anthracycline antibiotic that shows marked antibacterial activity against Gram-positive bacteria. Auramycin B also exhibits antitumor activity against P388 and L1210 leukemia in mice .

HY-N11972

β-Maaliene	Structural Classification Natural Products Source classification Myrtaceae Syzygium densiflorum Wall. ex Wight & Arn. Plants	Others
β-Maaliene can be isolated from the fresh leaves of Vitex densiflora (Maaliene) and is the main component in the isolate. β-Maaliene can significantly reduce the exercise capacity of mice at certain doses .

Cat. No.	Product Name	Chemical Structure

HY-B0448S

Phenytoin-d10
Phenytoin-d₁₀ is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].

HY-109506S1

DPPC-d9
DPPC-d₉ is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].

HY-109506S

DPPC-d62
DPPC-d₆₂ is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].

HY-B1002S

Oxolinic acid-d5
Oxolinic acid-d₅ is the deuterium labeled Oxolinic acid. Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].

HY-113354S

Anserine-d4

Anserine-d₄ is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].

HY-109506S3

DPPC-d9-1
DPPC-d₉-1 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].

HY-B0448S1

Phenytoin-15n2,13c
Phenytoin- ¹⁵N₂, ¹³C is the ¹³C and ¹⁵N labeled Phenytoin[1]. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[2][3].

HY-B1198S

Piperonyl butoxide-d9
Piperonyl butoxide-d₉ is the deuterium labeled Piperonyl butoxide.Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice .

HY-N1428S3

Citric acid-13C3
Citric acid- ¹³C₃ is the ¹³C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4].

HY-124412S

Paynantheine-d3
Paynantheine-d₃ is a deuterium labeled Paynantheine. Paynantheine is an alkaloid that can be isolated from Mitragyna speciosa. Paynantheine can decrease alcohol intake in mice .

HY-D0195S

Acesulfame-d4 potassium
Acesulfame-d₄ potassium is the deuterium labeled Acesulfame (potassium) (HY-D0195) . Acesulfame potassium is an artificial sweetener. Acesulfame potassium (long-term) affects cognitive functions, potentially via altering neuro-metabolic functions in mice .

HY-14393S

Emodin-d4

Emodin-d₄ is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

HY-B0534S1

Moclobemide-d4
Moclobemide-d₄ is deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HY-145119S

Mindeudesivir
GS-621763-d₁ is the deuterium labeled GS-621763 (HY-145119) . GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .

HY-14447S1

Bilastine-d4
Bilastine-d₄ is deuterium labeled Bilastine. Bilastine is an oral histamine H1-receptor antagonist. Bilastine can be used for allergic rhinitis and urticaria studies, and it also improves diabetic nephropathy in mice, showing safety for the central nervous system .

HY-109120S

Odevixibat-d5
Odevixibat-d₅ is deuterated labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-B0534S

Moclobemide-d8
Moclobemide-d₈ (Ro111163-d₈) is the deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC₅₀ of 6.061 μM for hMAO-A .Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HY-165677S

C22 Galactosylceramide-d4
C22 Galactosylceramide-d₄ is deuterium labeled C22 Galactosylceramide. C22 Galactosylceramide is a sphingolipid present in the central nervous system, exhibiting elevated levels in the spinal cord of mice on a methionine-restricted diet, while not affecting the brain or liver; furthermore, it has been identified in the postmortem hippocampus of Alzheimer's disease patients .

HY-N6608S

Physostigmine-d3

Physostigmine-d₃ is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].

HY-109120S1

Odevixibat-13C6
Odevixibat- ¹³C₆ is ¹³C labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-100442S

Paquinimod-d5
Paquinimod-d5 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

HY-100442S1

Paquinimod-d5-1
Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

HY-109506S2

(Rac)-DPPC-d6
(Rac)-DPPC-d6 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .

HY-101064S3

Fmoc-leucine-d10
Fmoc-leucine-d₁₀ is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].

HY-101064S2

Fmoc-leucine-d3
Fmoc-leucine-d₃ is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].

HY-109506S9

DPPC-13C2
DPPC-13C2 is a deuterated labeled DPPC . DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .

HY-113354S1

Anserine-d4 hydrochloride

Anserine-d₄ hydrochloride is the deuterium labeled Anserine (HY-113354). Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .

HY-N1428S6

Citric acid-d4-1
Citric acid-d₄-1 is deuterated labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.

HY-N9484S

Menthofuran-13C2

Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

HY-B0413S

Fenbendazole-d3

3 Publications Verification

Fenbendazole-d₃ is a deuterium labeled Fenbendazole. Fenbendazole-d₃ is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53[1][2][3][4].

HY-17623S

Tegoprazan-d6

Tegoprazan (CJ-12420; RQ-00000004), a potassium-competitive acid blocker, is a reversible, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC₅₀ values ranging from 0.29-0.52 μM for porcine, canine, and human H ⁺/K ⁺-ATPases in vitro. Tegoprazan significantly improves colitis in mice and enhances the intestinal epithelial barrier function. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases .

HY-12678S

Entrectinib-d4

Entrectinib-d4 (NMS-E628-d4; RXDX-101-d4) is the deuterium labeled Entrectinib (HY-12678). Entrectinib is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC₅₀ values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice .

HY-113421S

Linoleoyl ethanolamide-d4

Linoleoyl ethanolamide-d4 is a deuterated labeled Linoleoyl ethanolamide . Linoleoyl ethanolamide (Linoleic acid monoethanolamide) is classified as a fatty acid ethanolamide. Linoleoyl ethanolamide only weakly binds G-protein-coupled cannabinoid receptors of type-1（CB1）and CB2 receptors, and inhibits the binding of ^[3H]CP-55,940 with K_is of 10 and 25 μM, respectively. Linoleoyl ethanolamide is 4-fold less potent than anandamide at causing catalepsy in mice and it does not prolong sleep time .

HY-119980BS

Fluphenazine-d6 hydrochloride

Fluphenazine-d₆ (hydrochloride) is deuterium labeled Fluphenazine (hydrochloride). Fluphenazine hydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine hydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine hydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine hydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine hydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .

HY-119980S

Fluphenazine-d8

Fluphenazine-d₈ is the deuterium labeled Fluphenazine. Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2 .

HY-125527AS

17(R)-Resolvin D1-d5
17(R)-Resolvin D1-d₅ (17(R)-RvD1-d₅) is deuterium labeled 17(R)-Resolvin D1. 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells . 17R-Resolvin D1 specificially inhibits TRPV3 with an IC₅₀ of 398 nM and exhibits peripheral anti-nociceptive efficacy .

HY-12678S1

Entrectinib-d8

Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC₅₀ values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .

HY-W653921

Tenuazonic acid-d13

Tenuazonic acid-d₁₃ is deuterium labeled Tenuazonic acid. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a photosystem II (PSII) inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer .

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-163816

Antiproliferative agent-53-d3

Antiproliferative agent-53-d3 (Compound C1) is an inhibitor for theta-mediated end joining (TMEJ) in HEK293 cell with an IC₅₀ of 0.14 µM. Antiproliferative agent-53-d3 is the inhibitor for CYP2C19 and CYP2C9 with IC₅₀ of 0.77 and 3.1 µM. Antiproliferative agent-53-d3 inhibits the proliferation of DNA repair-compromised cells, with IC₅₀ of 8.1 µM for BRCA2 ^-/- DLD-1. Antiproliferative agent-53-d3 exhibits good pharmacokinetic characteristics in CD-1 mice .

Cat. No.	Product Name		Classification

HY-W001538

S-Propargylcysteine SPRC		Alkynes
S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H₂S-releasing compound. S-Propargylcysteine reduces Ca ²⁺ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties .

HY-16361A

Omigapil maleate CGP3466B; CGP3446 maleate; TCH346 maleate		Alkynes
Omigapil maleate, an orally bioavailable GAPDH nitrosylation inhibitor, abrogates Aβ_1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil maleate has the potential for the research of Alzheimer's disease . Omigapil maleate (CGP3446B maleate) is a apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD) . Omigapil (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-108039

Bezisterim HE 3286; NE-3107		Alkynes
Bezisterim (HE 3286; NE-3107) is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. Bezisterim is an orally active partial NF-κB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. Bezisterim freely penetrates the blood brain barrier in mice. Bezisterim can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis . Bezisterim is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151852

9AzNue5Ac		Azide Labeling and Fluorescence Imaging
9AzNue5Ac, 9-azido-9-deoxy-N-acetylneuraminic acid, is a click chemistry reagent and a Neu5Ac analogue with the substitution of 9-hydroxyl group with an azide. 9AzNue5Ac could be metabolized and incorporated into sialoglycans in living cells and mice. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-118950

J 628		Alkynes
J 628 is an estrogen derivative used to study antifertility effects after sexual intercourse in mice, rats, and rabbits .

HY-120171

DH-376		Alkynes
DH-376 is a potent diacylglycerol lipase inhibitor with pIC₅₀ values of 8.6 and 8.9 for ABHD6 and DAGLα, respectively. DH-376 prevents fasting-induced refeeding of mice . DH-376 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-156936

RCB-02-4-8		Cationic Lipids
RCB-02-4-8 is an ionizable cationic lipid that is used to form lipid nanoparticles (LNPs) to deliver mRNA. RCB-02-4-8 can improve the efficiency of lung transfection in mice .

HY-150725C

ODN 1585 sodium		CpG ODNs
ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 induces regression of established melanomas in mice. ODN 1585 can confer complete protection against malaria in mice. ODN 1585 sodium can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 can be used as a vaccine adjuvant .

HY-148506

5'-ODMT cEt m5U Phosphoramidite (Amidite)		Nucleoside Phosphoramidites
5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice .

HY-W590683

9A1P9		Cationic Lipids
9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for CRISPR-Cas9 gene editing in mice .

HY-B0892

Benzyl alcohol Benzenemethanol		Preservatives Solvents
Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor. Benzyl alcohol is an inhibitor of P450 enzyme. Benzyl alcohol mediated Toll-Like Receptor 4 to reduce the inflammatory response of liver injury in mice .

HY-145721A

Mongersen sodium GED-0301 sodium		Antisense Oligonucleotides
Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice .

HY-RS08427

MICAL3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MICAL3 Human Pre-designed siRNA Set A contains three designed siRNAs for MICAL3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08425

MICAL1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MICAL1 Human Pre-designed siRNA Set A contains three designed siRNAs for MICAL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08426

MICAL2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MICAL2 Human Pre-designed siRNA Set A contains three designed siRNAs for MICAL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-150725

ODN 1585		CpG ODNs
ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 induces regression of established melanomas in mice. ODN 1585 can confer complete protection against malaria in mice. ODN 1585 can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 can be used as a vaccine adjuvant .

HY-145721

Mongersen GED-0301		Antisense Oligonucleotides
Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice .

HY-109506

DPPC Maximum Cited Publications 6 Publications Verification 129Y83		Phospholipids
DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice .

HY-132579A

Tominersen sodium RG6042 sodium; IONIS-HTTRx sodium		Antisense Oligonucleotides
Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD) .

HY-154974

LNP Lipid-8		Cationic Lipids
LNP Lipid-8 (11-A-M) is an ionizable lipid, which can be used for lipid nanoparticles (LNP) to deliver siRNA to T cells without targeting to ligands. LNP LIPs-8 loaded with GFP siRNA (siGFP), and significantly causes GFP gene silencing in mice model .

HY-148413

Aprinocarsen sodium 1 Publications Verification ISIS 3521 sodium		Antisense Oligonucleotides
Aprinocarsen (ISIS 3521) sodium, a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α). Aprinocarsen sodium is a 20-mer oligonucleotide, it regulates cell differentiation and proliferation. Aprinocarsen sodium inhibits the growth of human tumor cell lines in nude mice. Aprinocarsen sodium shows the value as a chemotherapeutic compound of human cancers .

HY-13859

Clevudine L-FMAU		Nucleosides and their Analogs
Clevudine (L-FMAU), a nucleoside analog of the unnatural L-configuration, has potent anti-HBV activity with long half-life, low toxicity. Clevudine is a non-competitive inhibitor that is not incorporated into the viral DNA but rather binds to the polymerase. Clevudine is active against cowpox virus respiratory infection in mice .

HY-132579

Tominersen RG6042; IONIS-HTTRx		Antisense Oligonucleotides
Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) .

HY-153834

GTI 2040		Aptamers
GTI-2040, a 20-mer phosphorothioate oligonucleotide, was designed to hybridize to the mRNA sequence of human ribonucleotide reductase R2. GTI-2040 has been shown to inhibit human cancer cell proliferation by downregulation of R2 expression in vitro and to significantly inhibit tumor growth in xenograft models of human cancer in mice.

HY-153834A

GTI 2040 sodium		Aptamers
GTI-2040 sodium, a 20-mer phosphorothioate oligonucleotide, was designed to hybridize to the mRNA sequence of human ribonucleotide reductase R2. GTI-2040 sodium has been shown to inhibit human cancer cell proliferation by downregulation of R2 expression in vitro and to significantly inhibit tumor growth in xenograft models of human cancer in mice.

HY-160554

C12-113		Cationic Lipids
C12-113 is a lipidoid delivery agent that can be used to transfect siRNA into cells. C12-113 can also be combined with other lipids to form lipid nanoparticles (LNPs) for the delivery of mRNA encoding the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice .

HY-150236

FITC-labeled Tominersen sodium		Antisense Oligonucleotides
FITC-labeled Tominersen (sodium) is the Tominersen labeled with FITC. Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD).

HY-157252

CL4F8-6		Cationic Lipids
CL4F8-6 is an ionizable cationic lipid with a pK_a of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics. CL4F8-6 LNPs carrying Cas9 mRNA and sgRNA could induce CRISPR-mediated gene knockdown in mice .

HY-147080

Avacincaptad pegol sodium ARC1905		Aptamers
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system. Avacincaptad pegol sodium treats Geographic atrophy (GA) mice .

HY-153808

Complete Freund's adjuvant (CFA) 5 Publications Verification		Adjuvant
Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response .

HY-N0538

Xylitol Xylite		Fillers
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

KI mice

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Natural
Products