2. Search Result
Search Result
Results for "

NO level

" in MedChemExpress (MCE) Product Catalog:

1973

Inhibitors & Agonists

7

Screening Libraries

21

Fluorescent Dye

38

Biochemical Assay Reagents

113

Peptides

4

MCE Kits

11

Inhibitory Antibodies

329

Natural
Products

83

Isotope-Labeled Compounds

8

Click Chemistry

38

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D2377
    F8

    		Fluorescent Dye Others
    F8 is a small molecule GPR84 fluorescent probe that can visualize and detect GPR84 protein levels at the cellular and tissue levels .
    F8
  • HY-N1967
    Dihydrocurcumin

    		Fatty Acid Synthase (FASN) Metabolic Disease
    Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways .
    Dihydrocurcumin
  • HY-23119
    Sodium thiocyanate, GR, 99%

    Thiocyanate sodium

    		 Interleukin Related Reactive Oxygen Species Inflammation/Immunology
    Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine IL-10 levels. Sodium thiocyanate also significantly reduces of ROS formation .
    Sodium thiocyanate, GR, 99%
  • HY-N8063
    γ-Glutamylornithine

    		Endogenous Metabolite Others
    γ-Glutamylornithine is the urine excreta of patients with HHH syndrome (hyperuricemia, hyperaminemia, and hypercitrullinuria) and rotary atrophy associated with hyperuricemia. Increased levels of endogenous ornithine increase levels of γ-Glutamylornithine in the urine .
    γ-Glutamylornithine
  • HY-115449
    Chromeceptin
    1 Publications Verification

    94G6

    		 IGF-1R Akt mTOR Cancer
    Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR .
    Chromeceptin
  • HY-119855
    Aildenafil

    Methisosildenafil

    		 Phosphodiesterase (PDE) Cardiovascular Disease
    Aildenafil (Methisosildenafil) is a PDE-5 inhibitor that can induce vasodilation by increasing NO levels .
    Aildenafil
  • HY-167654
    Treloxinate

    		Others Cardiovascular Disease
    Treloxinate is an effective hypolipidemic agent. Treloxinate affects only triglyceride levels in Sprague-Dawley rats, but affects both triglyceride and cholesterol levels in Wistar rats .
    Treloxinate
  • HY-19061
    CGP 28014

    		COMT Neurological Disease
    CGP 28014 is a catechol-O-methyltransferase inhibitor. CGP 28014 can lower HVA levels and increase DOPAC levels in the striatum of rats, making it useful for research on Parkinson's disease .
    CGP 28014
  • HY-118113
    BVT-116429

    		11β-HSD Others
    BVT-116429 is an 11βHSD1 inhibitor with the activity of increasing adiponectin concentration and improving glucose homeostasis in diabetic mice. BVT-116429 can increase plasma adiponectin levels in diabetic KKAy mice, reduce basal insulin levels, and reduce fasting blood glucose levels after 10 days of inhibition, similar to the effect of rosiglitazone.
    BVT-116429
  • HY-N15293
    Sesamolinol

    		Others Metabolic Disease
    Sesamolinol is a lignin. Sesamolinol is found in sesame seeds. Sesame seed lignans are considered responsible for a number of beneficial health effects including lowering of plasma cholesterol levels and elevation of γ-tocopherol levels .
    Sesamolinol
  • HY-105912
    ONO 1082

    		Drug Derivative Endocrinology
    ONO 1082 is a Prostaglandin E1 (PGE1) (HY-B0131) derivative and increases cAMP level in hepatocytes. ONO 1082 competes with the action of the cholestatic factor through the increase in the cAMP level .
    ONO 1082
  • HY-P0165B
    Taspoglutide acetate

    ITM077 acetate; R1583 acetate; BIM51077 acetate

    		 GLP Receptor Metabolic Disease
    Taspoglutide (R1583) acetate is an agonist of the glucagon-like peptide 1 receptor (GLP-1R) with an Ki value of 1.1 nM. Taspoglutide acetate induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM). Taspoglutide acetate decreases blood levels of glucose and increases blood levels of insulin in a glucose tolerance test in Zucker diabetic obese rats. Taspoglutide acetate reduces blood levels of gastric inhibitory polypeptide (GIP), plasma levels of triglycerides, and body weight in the same model .
    Taspoglutide acetate
  • HY-112819
    Insulin levels modulator

    		Insulin Receptor Metabolic Disease Endocrinology
    Insulin levels modulator could be used to treat diabetes.
    Insulin levels modulator
  • HY-W845607
    Milacemide

    		Monoamine Oxidase Neurological Disease
    Milacemide, a glycinamide derivative, is an orally active MAO-B inhibitor with anticonvulsant activity. Milacemide reduces the levels of dihydroxyphenylacetic acid and homovanilic acid, but increases the levels of dopamine and serotonin in the caudate nucleus. Milacemide is promising for research of Alzheimer's disease .
    Milacemide
  • HY-122083
    T2384

    		PPAR Metabolic Disease
    T2384 is a peroxisome proliferator-activated receptor γ (PPARγ) ligand. T2384 also is an orally active antidiabetic agent. T2384 reduces the fasting plasma glucose levels and plasma insulin levels .
    T2384
  • HY-148748
    Butyzamide

    		JAK STAT p38 MAPK Others
    Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay .
    Butyzamide
  • HY-N1427R
    Glycodeoxycholate Sodium (Standard)

    Sodium glycyldeoxycholate (Standard)

    		 Endogenous Metabolite Metabolic Disease
    Glycodeoxycholate (Sodium) (Standard) is the analytical standard of Glycodeoxycholate (Sodium). This product is intended for research and analytical applications. Glycodeoxycholate Sodium (Sodium glycyldeoxycholate) is a bile salt. Glycodeoxycholate Sodium has cytotoxicity to cancer cell, changes the permeability of the pancreatic duct and decreases glucose levels[1][2][3].
    Glycodeoxycholate Sodium (Standard)
  • HY-W013816
    Dipentyl phthalate

    		AMPK Akt Metabolic Disease
    Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant .
    Dipentyl phthalate
  • HY-156277
    SP4f

    		PPAR Metabolic Disease
    SP4f is an activator ofPPAR-γ, with the EC50 of 826 nM in HK-2 cells. SP4f reduces the blood glucose levels and lipid peroxidation, and increases glutathione levels and catalase activityin the Swiss albino mice .
    SP4f
  • HY-107736
    AI-3

    		Keap1-Nrf2 Inflammation/Immunology Cancer
    AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases .
    AI-3
  • HY-156276
    SP4e

    		PPAR Metabolic Disease
    SP4e is an activator of PPAR-γ, with the EC50 of 739 nM in HK-2 cells. SP4e reduces the blood glucose levels and lipid peroxidation, and increases glutathione levels and catalase activityin the Swiss albino mice .
    SP4e
  • HY-109101S
    Risdiplam-d4

    		DNA/RNA Synthesis Neurological Disease
    Risdiplam-d4 is deuterium labeled Risdiplam. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels[1].
    Risdiplam-d4
  • HY-13506G
    M344 (GMP)

    D 237 (GMP); MS 344 (GMP)

    		 HDAC Cancer
    M344 (GMP) (D 237) (GMP) is the GMP level of M344 (HY-13506). GMP level of small molecules can be used as auxiliary reagents in cell therapy. M344 is a kind of histone acetylation enzyme inhibitor .
    M344 (GMP)
  • HY-B0260S
    Methylprednisolone-d3

    U 7532-d3

    		 Glucocorticoid Receptor Autophagy SARS-CoV Infection Inflammation/Immunology Endocrinology Cancer
    Methylprednisolone-d3 is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].
    Methylprednisolone-d3
  • HY-130205
    Milacemide hydrochloride

    CP 1552 S

    		 Monoamine Oxidase Neurological Disease
    Milacemide hydrochloride (CP 1552 S), a glycinamide derivative, is an orally active MAO-B inhibitor with anticonvulsant activity. Milacemide hydrochloride reduces the levels of dihydroxyphenylacetic acid and homovanilic acid, but increases the levels of dopamine and serotonin in the caudate nucleus. Milacemide hydrochloride is promising for research of Alzheimer's disease .
    Milacemide hydrochloride
  • HY-162168
    Anti-inflammatory agent 71

    		COX Inflammation/Immunology
    Anti-inflammatory agent 71 (Compound 3.2) is an anti-inflammatory agent that can reduce the levels of neutrophils, COX-2, nitrotyrosine, IL-1b, and C-reactive protein, while increasing the level of eNOS .
    Anti-inflammatory agent 71
  • HY-B0260S2
    Methylprednisolone-d4

    U 7532-d4

    		 Isotope-Labeled Compounds Glucocorticoid Receptor Autophagy SARS-CoV Infection Inflammation/Immunology Endocrinology Cancer
    Methylprednisolone-d4 is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].
    Methylprednisolone-d4
  • HY-B0260S3
    Methylprednisolone-d7

    U 7532-d7

    		 Glucocorticoid Receptor Autophagy SARS-CoV Infection Inflammation/Immunology Endocrinology Cancer
    Methylprednisolone-d7 is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].
    Methylprednisolone-d7
  • HY-Y0537B
    Potassium chloride, for molecular biology

    		Biochemical Assay Reagents Cancer
    Potassium chloride, for molecular biology is a potassium chloride that can be used at the molecular level for protein extraction and solubilization.
    Potassium chloride, for molecular biology
  • HY-116653
    Flurtamone

    		Stearoyl-CoA Desaturase (SCD) Others
    Flurtamone is a chiral herbicide with acute toxicity levels to Selenastrum capricornutum .
    Flurtamone
  • HY-B0260S4
    Methylprednisolone-d2

    U 7532-d2

    		 Glucocorticoid Receptor Autophagy SARS-CoV Others
    Methylprednisolone-d2 is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3][4].
    Methylprednisolone-d2
  • HY-153017
    HIF-1 inhibitor-4

    		HIF/HIF Prolyl-Hydroxylase Cancer
    HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level .
    HIF-1 inhibitor-4
  • HY-W679754
    Pentacosafluorotridecanoic Acid

    PFTrDA

    		 TSH Receptor Infection
    Perfluorotridecanoic acid (PFTrDA) is a perfluoroalkyl substance (PFAS). Embryo larval exposure of PFTrDA induces yolk sac edema and increases mRNA expression of thyroid hormone synthesis genes, including tshβ, in zebrafish when used at concentrations of 0.1 and 0.3 mg/L, respectively. PFTrDA (10 mg/kg) decreases serum testosterone and luteinizing hormone levels, testis palmitic acid, linoleic acid, and oleic acid levels, and the number of Leydig cells in rats in late puberty. Maternal plasma levels of PFTrDA during gestation are positively associated with the development of eczema in female, but not male, infants, and liver levels of PFTrDA are higher in cancerous human livers compared with non-cancerous human livers. It has been found in marine mammals.
    Pentacosafluorotridecanoic Acid
  • HY-Y0537E
    Potassium chloride, for cell culture

    		Biochemical Assay Reagents Inflammation/Immunology
    Potassium chloride, for cell culture is a form of potassium chloride that can be used at the cellular level and can be used as a potassium supplement.
    Potassium chloride, for cell culture
  • HY-162547
    Oxogestone phenpropionate

    		Endogenous Metabolite Endocrinology
    Oxogestone phenpropionate is a progesterone that can be used in studies to regulate hormone levels .
    Oxogestone phenpropionate
  • HY-115360
    IND45193

    		Prion Protein Others
    IND45193 is a compound used to inhibit prion disease, with activity in reducing PrP(Sc) levels. In cells infected with prions, IND45193 can reduce PrP(Sc) levels, and its activity was determined through screening of multiple cell types and concentration-effect relationship studies.
    IND45193
  • HY-123171
    ASP8497

    		Dipeptidyl Peptidase Metabolic Disease
    ASP8497 is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor that reduces blood glucose levels and increases plasma active GLP-1 and insulin levels without causing hypoglycemia in fasted normal mice. ASP8497 can be utilized for antihyperglycemic research .
    ASP8497
  • HY-158827A
    AZD8233 sodium

    		PCSK9 Metabolic Disease
    AZD8233 sodium, a liver-targeting antisense oligonucleotide (ASO), inhibits subtilisin/kexin type 9 (PCSK9) protein synthesis. AZD8233 sodium increases the available LDL receptors by reducing PCSK9 levels, thereby clearing LDL from the blood and decreasing LDL-C levels.
    AZD8233 sodium
  • HY-118570
    5-Oxoprolyltryptophan

    		Biochemical Assay Reagents Neurological Disease
    5-Oxoprolyltryptophan is a model substrate for investigating the increase of serotonin at the cerebral level .
    5-Oxoprolyltryptophan
  • HY-W046704
    1-Methoxycyclopropanecarboxylic acid

    		Mitochondrial Metabolism Others
    1-Methoxycyclopropanecarboxylic acid is a decoupler that stimulates respiration to about 160% of baseline levels .
    1-Methoxycyclopropanecarboxylic acid
  • HY-101606
    Etersalate

    Eterylate; Etherylate

    		 Prostaglandin Receptor Cardiovascular Disease Endocrinology
    Etersalate inhibits platelet function and decreases thromboxane A2 (TXA2) levels.
    Etersalate
  • HY-P0092
    Cecropin B
    1 Publications Verification

    		 Cytochrome P450 Bacterial Antibiotic Infection Cancer
    Cecropin B has high level of antimicrobial activity and is considered as a valuable peptide antibiotic.
    Cecropin B
  • HY-155203
    Anticancer agent 154

    		Apoptosis Reactive Oxygen Species Ferroptosis Cancer
    Anticancer agent 154 (Compound 8h) increases the levels of reactive oxygen species and leads to mitochondrial damage. Anticancer agent 154 induces cell apoptosis and DNA damage. Anticancer agent 154 also induces ferroptosis by reducing the GSH level and GPX4 expression and increasing the lipid peroxidation level. Anticancer agent 154 inhibits cancer cell (HT29, H1975, A549, and MCF-7) proliferation with IC50s of 1.0-1.9 μM .
    Anticancer agent 154
  • HY-112575
    Tiazotic acid

    		NO Synthase Infection Cardiovascular Disease Inflammation/Immunology
    Tiazotic acid is a metabolic agent that has immunomodulatory, anti-inflammatory, antioxidant, anti-ischemic, cardio- and endothelioprotective, antiplatelet, hepatoprotective activities. Tiazotic acid increases the levels of eNOS. Tiazotic acid also reduces the level of D-dimer in the blood, which reduces the risks of heart attacks and strokes in post-COVID syndrome .
    Tiazotic acid
  • HY-N13235
    Garlic Extract

    		Bacterial Antibiotic Cardiovascular Disease
    Garlic Extract is a garlic extract, and its components include: Allicin. Garlic Extract is beneficial to cardiovascular disease and has the potential to reduce the risk of cardiovascular disease. Garlic Extract can effectively reduce total cholesterol, low-density lipoprotein levels and improve high-density lipoprotein levels. .
    Garlic Extract
  • HY-158827
    AZD8233

    		PCSK9 Metabolic Disease
    AZD8233, a liver-targeting antisense oligonucleotide (ASO), inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) protein synthesis. AZD8233 increases the available LDL receptors by reducing PCSK9 levels, thereby clearing LDL from the blood and decreasing LDL-C levels.
    AZD8233
  • HY-W679754R
    Pentacosafluorotridecanoic Acid (Standard)

    		TSH Receptor Infection
    Pentacosafluorotridecanoic Acid (Standard) is the analytical standard of Pentacosafluorotridecanoic Acid. This product is intended for research and analytical applications. Perfluorotridecanoic acid (PFTrDA) is a perfluoroalkyl substance (PFAS). Embryo larval exposure of PFTrDA induces yolk sac edema and increases mRNA expression of thyroid hormone synthesis genes, including tshβ, in zebrafish when used at concentrations of 0.1 and 0.3 mg/L, respectively. PFTrDA (10 mg/kg) decreases serum testosterone and luteinizing hormone levels, testis palmitic acid, linoleic acid, and oleic acid levels, and the number of Leydig cells in rats in late puberty. Maternal plasma levels of PFTrDA during gestation are positively associated with the development of eczema in female, but not male, infants, and liver levels of PFTrDA are higher in cancerous human livers compared with non-cancerous human livers. It has been found in marine mammals.
    Pentacosafluorotridecanoic Acid (Standard)
  • HY-19005
    GYKI-32887

    		Dopamine Receptor Neurological Disease
    GYKI-32887 is a dopaminergic agonist that can reduce the motor activity levels in rats .
    GYKI-32887
  • HY-W069508
    3-(Aminomethyl)phenol

    m-Hydroxybenzylamine

    		 Dopamine Receptor Neurological Disease
    3-(Aminomethyl)phenol (m-Hydroxybenzylamine) reduces prefrontal Dopemine (DA) levels .
    3-(Aminomethyl)phenol
  • HY-16027
    Acyline

    		GnRH Receptor Endocrinology
    Acyline, a GnRH peptide analogue, is a GnRH antagonist that inhibits gonadotropin and testosterone (T) levels .
    Acyline

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: