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Brain

" in MedChemExpress (MCE) Product Catalog:

1928

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145

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213

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Oligonucleotides

Cat. No. Product Name Type
  • HY-157355
    Brain Heart Infusion Broth

    BHI

    		 Microbial Culture
    Brain Heart Infusion Broth (BHI) is suitable for microbiological culture (For example: Anopheles arabiensis).
  • HY-D0714
    Tetrazolium Red
    3 Publications Verification

    2,3,5-Triphenyltetrazolium chloride; TPTZ; TTC

    		 Enzyme Substrates
    Tetrazolium Red (2,3,5-Triphenyltetrazolium chloride; TTC) is a not brain-penetrant, colorless, water-soluble dye that is reduced by mitochondrial enzymes to a deep red, water-insoluble compound (formazan) mainly in the mitochondria of living cells. Tetrazolium Red is used to observe the activity of dehydrogenase, and it turns colorless to red when exposed to hydrogen. Tetrazolium Red distinguishes between surviving and infarcted brain tissue after stroke. Tetrazolium Red has been used to stain heart tissue to measure the extent of acute lesions and also used to stain brain tissue to detect the size of the infarcted area. The absorption wavelength of Tetrazolium Red is 570 nm .
  • HY-137499
    NT1-O12B

    		Drug Delivery
    NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination .
  • HY-101183
    THK5351

    		Indicators
    THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain.
  • HY-W250174
    Lithium 3,5-diiodosalicylate

    3,5-Diiodosalicylic acid lithium salt

    		 Biochemical Assay Reagents
    Lithium 3,5-diiodosalicylate is a compound used in the study of bipolar disorder and other psychiatric disorders. It contains lithium and a salicylate. Lithium 3,5-diiodosalicylate works by affecting the levels of certain neurotransmitters in the brain, including dopamine and serotonin.
  • HY-D0873
    HEPPS

    EPPS

    		 Buffer Reagents
    HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier .
  • HY-157375
    Brain Heart Infusion Agar

    		Microbial Culture
    Brain Heart Infusion Agar is growth medium for the cultivation of a wide variety of microorganisms .
  • HY-W203728
    L-β-Imidazolelactic acid

    		Microbial Culture
    L-β-Imidazolelactic acid is a histidine derivative and an oxidizing agent that can trigger antioxidant effects in the brain cortex of rats .
  • HY-W015715
    5-Methylresorcinol monohydrate

    Orcinol monohydrate

    		 Indicators
    5-Methylresorcinol monohydrate (Orcinol monohydrate) is a tyrosinase inhibitor. 5-Methylresorcinol monohydrate shows cytotoxicity. 5-Methylresorcinol monohydrate also is an oral active and cross the blood-brain barrier anxiolytic agent .
  • HY-NP019
    Agkistrodon halys batroxobin

    		Native Proteins
    Agkistrodon halys batroxobin is a thrombin-like serine protease. Agkistrodon halys batroxobin reduces the expression of Sirt1 and extracellular signal-regulated kinase activation in brain tissue. Agkistrodon halys batroxobin reduces cleaved caspase-3 expression and inhibits neuronal apoptosis in rat .
  • HY-W013851
    EDTA-OH

    		Chelators
    EDTA-OH is a chelating agent, which forms thermodynamically stable chelates with metal ions like calcium, magnesium, iron, zinc and copper . EDTA-OH exhibits ability of phytoremediation in heavy-metal-contaminated soils . EDTA-OH is able to cross brain-blood barrier .
  • HY-D0884
    L-Lactic acid lithium
    5 Publications Verification

    (S)-2-Hydroxypropanoic acid lithium

    		 Biochemical Assay Reagents
    L-Lactic acid (lithium) is a chemical compound belonging to the class of lithium salts. It is commonly used in the pharmaceutical industry as a mood stabilizer and antipsychotic for the improvement of bipolar disorder and schizophrenia. L-Lactic acid (lithium) works by affecting the balance of certain chemicals in the brain, which can help reduce symptoms such as mood swings, aggression, and hallucinations.
  • HY-W042416
    N,N-Dimethylacetamide
    1 Publications Verification

    DMAc

    		 Co-solvents
    N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .
  • HY-163551
    BNP peptide/KLH

    		Biochemical Assay Reagents
    The BNP peptide/KLH is an antigen-adjuvant conjugate formed by linking BNP peptide (human brain natriuretic peptide) with keyhole limpet hemocyanin (KLH). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or damage the major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
  • HY-12495A
    ISRIB
    10+ Cited Publications

    		 Cell Assay Reagents
    ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .
  • HY-137500
    NT1-014B

    		Drug Delivery
    NT1-014B is a potent NT1-lipidoid encapsulated AmB (amphotericin B). NT1-014B dopes the NT-lipidoids into BBB-impermeable lipid nanoparticles (LNPs) gave the LNPs the ability to cross the BBB. NT1-014B enhances brain delivery through intravenous injection .
  • HY-B1102
    Evans Blue
    Maximum Cited Publications
    16 Publications Verification

    Direct Blue 53; T-1824; C.I. 23860

    		 Cell Assay Reagents
    Evans Blue (Direct Blue 53) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability .
  • HY-115340
    Decanoic acid sodium

    		Drug Delivery
    Decanoic acid sodium, also known as Decanoic acid sodium, is a salt of the fatty acid capric acid. It is easily soluble in water and has a slightly soapy smell. Decanoic acid sodium acts as a penetration enhancer, which means it increases the absorption and bioavailability of drugs across biological membranes, including the intestinal epithelium and the blood-brain barrier. This property makes it useful in pharmaceutical formulations to improve drug delivery and effectiveness. Furthermore, Decanoic acid sodium has potential applications in food preservatives and cosmetics due to its antibacterial properties.
  • HY-W042416R
    N,N-Dimethylacetamide (Standard)

    		Co-solvents
    N,N-Dimethylacetamide (Standard) is the analytical standard of N,N-Dimethylacetamide. This product is intended for research and analytical applications. N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .
  • HY-125139
    omega-3 Arachidonic acid ethyl ester, in ethanol, 98%

    ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%

    		 Drug Delivery
    omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.
  • HY-D1056A4
    Lipopolysaccharides, from E. coli O128:B12

    LPS, from Escherichia coli (O128:B12)

    		 Carbohydrates
    Lipopolysaccharides, from E. coli O128:B12 is commonly used to stimulate the inflammatory pathway in an infection/inflammation induced preterm animal model. Specific Lipopolysaccharides from E. coli serotypes induce activation of different inflammatory pathways in the neonatal rat brain. Compared with other Escherichia coli, Lipopolysaccharides (O111:B4, O55:B5, O127:B8), Lipopolysaccharides, from E. coli O128:B12 has lower induction efficiency of inflammation. Cub survival rate was 100% after the treatment .

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